PMC:2952583 / 35490-36480 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2952583","sourcedb":"PMC","sourceid":"2952583","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2952583","text":"We observed that sFlt1 and sEng were statistically higher, and PlGF was significantly lower at 26 to 30 weeks' gestation or later during pregnancy in subjects who later develop preeclampsia in some but not all of the four high-risk groups. In addition, we observed that there were relatively few significant differences in the concentration of these angiogenic factors that precede the onset of the clinical syndrome of preeclampsia. In most cases, however, even when the differences are not significant, the relationship of mean values of these angiogenic factors is similar to that observed in low-risk women with higher sFlt1 and sEng and lower PlGF in women who later develop preeclampsia suggesting these factors may play a role in the pathophysiology of preeclampsia in these high-risk groups. Nonetheless, the small differences in these factors or their ratio make it unlikely they will be clinically useful as individual predictive markers of preeclampsia in these high-risk groups.","tracks":[]}