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myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1. The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli. AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter. In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation. Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli. In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10. Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment. 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The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli. AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter. In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation. Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli. In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10. Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment. Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration. Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression."}

{"project":"GO-BP","denotations":[{"id":"T971","span":{"begin":67,"end":77},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T972","span":{"begin":95,"end":105},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T973","span":{"begin":304,"end":314},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T974","span":{"begin":741,"end":751},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T975","span":{"begin":782,"end":792},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T976","span":{"begin":857,"end":867},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T987","span":{"begin":301,"end":331},"obj":"http://purl.obolibrary.org/obo/GO_0032722"},{"id":"T988","span":{"begin":922,"end":931},"obj":"http://purl.obolibrary.org/obo/GO_0022809"},{"id":"T989","span":{"begin":1032,"end":1048},"obj":"http://purl.obolibrary.org/obo/GO_0051092"},{"id":"T990","span":{"begin":1262,"end":1278},"obj":"http://purl.obolibrary.org/obo/GO_0051092"},{"id":"T991","span":{"begin":1078,"end":1088},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T993","span":{"begin":1099,"end":1102},"obj":"http://purl.obolibrary.org/obo/GO_0004697"},{"id":"T994","span":{"begin":1129,"end":1132},"obj":"http://purl.obolibrary.org/obo/GO_0004697"},{"id":"T995","span":{"begin":1519,"end":1522},"obj":"http://purl.obolibrary.org/obo/GO_0004697"},{"id":"T996","span":{"begin":1153,"end":1168},"obj":"http://purl.obolibrary.org/obo/GO_1904627"},{"id":"T997","span":{"begin":1262,"end":1288},"obj":"http://purl.obolibrary.org/obo/GO_1903721"},{"id":"T998","span":{"begin":1468,"end":1471},"obj":"http://purl.obolibrary.org/obo/GO_0004705"},{"id":"T3781","span":{"begin":67,"end":77},"obj":"http://purl.obolibrary.org/obo/GO_0065007"}],"text":"Results\nPhorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1. The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli. AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter. In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation. Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli. In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10. Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment. Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration. Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression."}

{"project":"GO-MF","denotations":[{"id":"T1007","span":{"begin":387,"end":391},"obj":"http://purl.obolibrary.org/obo/GO_0005138"},{"id":"T1008","span":{"begin":1325,"end":1329},"obj":"http://purl.obolibrary.org/obo/GO_0005138"},{"id":"T1009","span":{"begin":1508,"end":1512},"obj":"http://purl.obolibrary.org/obo/GO_0005138"},{"id":"T1011","span":{"begin":378,"end":382},"obj":"http://purl.obolibrary.org/obo/GO_0005134"},{"id":"T1012","span":{"begin":493,"end":498},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T1013","span":{"begin":922,"end":931},"obj":"http://purl.obolibrary.org/obo/GO_0022809"},{"id":"T1014","span":{"begin":1099,"end":1102},"obj":"http://purl.obolibrary.org/obo/GO_0004697"},{"id":"T1015","span":{"begin":1129,"end":1132},"obj":"http://purl.obolibrary.org/obo/GO_0004697"},{"id":"T1016","span":{"begin":1519,"end":1522},"obj":"http://purl.obolibrary.org/obo/GO_0004697"},{"id":"T1017","span":{"begin":1468,"end":1471},"obj":"http://purl.obolibrary.org/obo/GO_0004705"}],"text":"Results\nPhorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1. The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli. AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter. In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation. Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli. In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10. Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment. Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration. Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression."}

{"project":"GO-CC","denotations":[{"id":"T1020","span":{"begin":1434,"end":1439},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1022","span":{"begin":804,"end":817},"obj":"http://purl.obolibrary.org/obo/GO_0005622"}],"text":"Results\nPhorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1. The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli. AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter. In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation. Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli. In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10. Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment. Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration. Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression."}

{"project":"sentences","denotations":[{"id":"T124","span":{"begin":0,"end":7},"obj":"Sentence"},{"id":"T125","span":{"begin":8,"end":267},"obj":"Sentence"},{"id":"T126","span":{"begin":268,"end":576},"obj":"Sentence"},{"id":"T127","span":{"begin":577,"end":681},"obj":"Sentence"},{"id":"T128","span":{"begin":682,"end":793},"obj":"Sentence"},{"id":"T129","span":{"begin":794,"end":1005},"obj":"Sentence"},{"id":"T130","span":{"begin":1006,"end":1113},"obj":"Sentence"},{"id":"T131","span":{"begin":1114,"end":1252},"obj":"Sentence"},{"id":"T132","span":{"begin":1253,"end":1411},"obj":"Sentence"},{"id":"T133","span":{"begin":1412,"end":1570},"obj":"Sentence"},{"id":"T7","span":{"begin":0,"end":7},"obj":"Sentence"},{"id":"T8","span":{"begin":8,"end":267},"obj":"Sentence"},{"id":"T9","span":{"begin":268,"end":576},"obj":"Sentence"},{"id":"T10","span":{"begin":577,"end":681},"obj":"Sentence"},{"id":"T11","span":{"begin":682,"end":793},"obj":"Sentence"},{"id":"T12","span":{"begin":794,"end":1005},"obj":"Sentence"},{"id":"T13","span":{"begin":1006,"end":1113},"obj":"Sentence"},{"id":"T14","span":{"begin":1114,"end":1252},"obj":"Sentence"},{"id":"T15","span":{"begin":1253,"end":1411},"obj":"Sentence"},{"id":"T16","span":{"begin":1412,"end":1570},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Results\nPhorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1. The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli. AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter. In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation. Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli. In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10. Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment. Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration. Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression."}

{"project":"events-check-again","denotations":[{"id":"T1220","span":{"begin":301,"end":314},"obj":"Positive_regulation"},{"id":"T1221","span":{"begin":301,"end":314},"obj":"Positive_regulation"},{"id":"T1222","span":{"begin":301,"end":314},"obj":"Positive_regulation"},{"id":"T1223","span":{"begin":332,"end":337},"obj":"Protein"},{"id":"T1224","span":{"begin":378,"end":382},"obj":"Protein"},{"id":"T1225","span":{"begin":387,"end":391},"obj":"Protein"},{"id":"T1226","span":{"begin":493,"end":498},"obj":"Protein"},{"id":"T1227","span":{"begin":508,"end":516},"obj":"Regulation"},{"id":"T1228","span":{"begin":547,"end":561},"obj":"Negative_regulation"},{"id":"T1229","span":{"begin":1107,"end":1112},"obj":"Protein"},{"id":"T1230","span":{"begin":1191,"end":1196},"obj":"Protein"},{"id":"T1231","span":{"begin":1218,"end":1227},"obj":"Negative_regulation"},{"id":"T1232","span":{"begin":1311,"end":1321},"obj":"Negative_regulation"},{"id":"T1233","span":{"begin":1325,"end":1329},"obj":"Protein"},{"id":"T1234","span":{"begin":1330,"end":1340},"obj":"Gene_expression"},{"id":"T1235","span":{"begin":1347,"end":1352},"obj":"Protein"},{"id":"T1236","span":{"begin":1365,"end":1374},"obj":"Negative_regulation"},{"id":"T1237","span":{"begin":1482,"end":1492},"obj":"Negative_regulation"},{"id":"T1238","span":{"begin":1482,"end":1492},"obj":"Negative_regulation"},{"id":"T1239","span":{"begin":1498,"end":1503},"obj":"Protein"},{"id":"T1240","span":{"begin":1508,"end":1512},"obj":"Protein"},{"id":"T1241","span":{"begin":1543,"end":1552},"obj":"Negative_regulation"},{"id":"T1242","span":{"begin":1553,"end":1558},"obj":"Protein"},{"id":"T1243","span":{"begin":1559,"end":1569},"obj":"Gene_expression"}],"relations":[{"id":"R881","pred":"themeOf","subj":"T1223","obj":"T1222"},{"id":"R882","pred":"themeOf","subj":"T1224","obj":"T1220"},{"id":"R883","pred":"themeOf","subj":"T1225","obj":"T1221"},{"id":"R884","pred":"themeOf","subj":"T1226","obj":"T1227"},{"id":"R885","pred":"themeOf","subj":"T1226","obj":"T1228"},{"id":"R886","pred":"themeOf","subj":"T1230","obj":"T1231"},{"id":"R887","pred":"themeOf","subj":"T1233","obj":"T1234"},{"id":"R888","pred":"themeOf","subj":"T1234","obj":"T1232"},{"id":"R889","pred":"themeOf","subj":"T1235","obj":"T1236"},{"id":"R890","pred":"themeOf","subj":"T1239","obj":"T1237"},{"id":"R891","pred":"themeOf","subj":"T1240","obj":"T1238"},{"id":"R892","pred":"themeOf","subj":"T1242","obj":"T1243"},{"id":"R893","pred":"themeOf","subj":"T1243","obj":"T1241"}],"attributes":[{"id":"M30","pred":"Negation","subj":"T1227","obj":"true"}],"text":"Results\nPhorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1. The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli. AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter. In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation. Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli. In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10. Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment. Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration. Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression."}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T1267","span":{"begin":81,"end":85},"obj":"Protein"},{"id":"T1268","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T1269","span":{"begin":229,"end":234},"obj":"Protein"},{"id":"T1270","span":{"begin":262,"end":266},"obj":"Protein"},{"id":"T1271","span":{"begin":64,"end":77},"obj":"Positive_regulation"},{"id":"T1272","span":{"begin":90,"end":105},"obj":"Negative_regulation"},{"id":"T1273","span":{"begin":217,"end":225},"obj":"Positive_regulation"},{"id":"T1274","span":{"begin":252,"end":261},"obj":"Regulation"},{"id":"T1275","span":{"begin":49,"end":57},"obj":"Positive_regulation"},{"id":"T1276","span":{"begin":49,"end":57},"obj":"Positive_regulation"},{"id":"T1277","span":{"begin":64,"end":77},"obj":"Positive_regulation"},{"id":"T1278","span":{"begin":332,"end":337},"obj":"Protein"},{"id":"T1279","span":{"begin":363,"end":382},"obj":"Protein"},{"id":"T1280","span":{"begin":387,"end":391},"obj":"Protein"},{"id":"T1281","span":{"begin":301,"end":314},"obj":"Positive_regulation"},{"id":"T1282","span":{"begin":301,"end":314},"obj":"Positive_regulation"},{"id":"T1283","span":{"begin":301,"end":314},"obj":"Positive_regulation"},{"id":"T1284","span":{"begin":508,"end":516},"obj":"Regulation"},{"id":"T1285","span":{"begin":508,"end":516},"obj":"Regulation"},{"id":"T1286","span":{"begin":508,"end":516},"obj":"Regulation"},{"id":"T1287","span":{"begin":508,"end":516},"obj":"Regulation"},{"id":"T1288","span":{"begin":577,"end":581},"obj":"Protein"},{"id":"T1289","span":{"begin":582,"end":592},"obj":"Positive_regulation"},{"id":"T1290","span":{"begin":611,"end":620},"obj":"Positive_regulation"},{"id":"T1291","span":{"begin":661,"end":669},"obj":"Positive_regulation"},{"id":"T1292","span":{"begin":695,"end":700},"obj":"Protein"},{"id":"T1293","span":{"begin":738,"end":751},"obj":"Positive_regulation"},{"id":"T1294","span":{"begin":777,"end":792},"obj":"Negative_regulation"},{"id":"T1295","span":{"begin":738,"end":751},"obj":"Positive_regulation"},{"id":"T1296","span":{"begin":871,"end":876},"obj":"Protein"},{"id":"T1297","span":{"begin":954,"end":959},"obj":"Protein"},{"id":"T1298","span":{"begin":994,"end":1004},"obj":"Protein"},{"id":"T1299","span":{"begin":852,"end":867},"obj":"Negative_regulation"},{"id":"T1300","span":{"begin":979,"end":988},"obj":"Positive_regulation"},{"id":"T1301","span":{"begin":946,"end":953},"obj":"Negative_regulation"},{"id":"T1302","span":{"begin":1035,"end":1037},"obj":"Protein"},{"id":"T1303","span":{"begin":1099,"end":1102},"obj":"Protein"},{"id":"T1304","span":{"begin":1107,"end":1112},"obj":"Protein"},{"id":"T1305","span":{"begin":1038,"end":1048},"obj":"Positive_regulation"},{"id":"T1306","span":{"begin":1129,"end":1132},"obj":"Protein"},{"id":"T1307","span":{"begin":1114,"end":1128},"obj":"Phosphorylation"},{"id":"T1308","span":{"begin":1140,"end":1149},"obj":"Positive_regulation"},{"id":"T1309","span":{"begin":1140,"end":1149},"obj":"Positive_regulation"},{"id":"T1310","span":{"begin":1262,"end":1267},"obj":"Protein"},{"id":"T1311","span":{"begin":1325,"end":1329},"obj":"Protein"},{"id":"T1312","span":{"begin":1347,"end":1352},"obj":"Protein"},{"id":"T1313","span":{"begin":1279,"end":1288},"obj":"Negative_regulation"},{"id":"T1314","span":{"begin":1330,"end":1340},"obj":"Gene_expression"},{"id":"T1315","span":{"begin":1365,"end":1374},"obj":"Negative_regulation"},{"id":"T1316","span":{"begin":1311,"end":1321},"obj":"Negative_regulation"},{"id":"T1317","span":{"begin":1468,"end":1471},"obj":"Protein"},{"id":"T1318","span":{"begin":1498,"end":1503},"obj":"Protein"},{"id":"T1319","span":{"begin":1508,"end":1512},"obj":"Protein"},{"id":"T1320","span":{"begin":1519,"end":1522},"obj":"Protein"},{"id":"T1321","span":{"begin":1553,"end":1558},"obj":"Protein"},{"id":"T1322","span":{"begin":1472,"end":1481},"obj":"Negative_regulation"},{"id":"T1323","span":{"begin":1482,"end":1492},"obj":"Negative_regulation"},{"id":"T1324","span":{"begin":1482,"end":1492},"obj":"Negative_regulation"},{"id":"T1325","span":{"begin":1523,"end":1532},"obj":"Negative_regulation"},{"id":"T1326","span":{"begin":1559,"end":1569},"obj":"Gene_expression"},{"id":"T1327","span":{"begin":1543,"end":1552},"obj":"Negative_regulation"},{"id":"T3812","span":{"begin":81,"end":85},"obj":"Protein"},{"id":"T3816","span":{"begin":67,"end":77},"obj":"Regulation"},{"id":"T3817","span":{"begin":67,"end":77},"obj":"Regulation"}],"relations":[{"id":"R903","pred":"themeOf","subj":"T1267","obj":"T1271"},{"id":"R904","pred":"themeOf","subj":"T1268","obj":"T1272"},{"id":"R905","pred":"themeOf","subj":"T1269","obj":"T1273"},{"id":"R906","pred":"themeOf","subj":"T1270","obj":"T1274"},{"id":"R907","pred":"themeOf","subj":"T1271","obj":"T1275"},{"id":"R908","pred":"themeOf","subj":"T1272","obj":"T1276"},{"id":"R909","pred":"themeOf","subj":"T1272","obj":"T1277"},{"id":"R910","pred":"themeOf","subj":"T1278","obj":"T1281"},{"id":"R911","pred":"themeOf","subj":"T1279","obj":"T1282"},{"id":"R912","pred":"themeOf","subj":"T1280","obj":"T1283"},{"id":"R913","pred":"themeOf","subj":"T1280","obj":"T1284"},{"id":"R914","pred":"themeOf","subj":"T1281","obj":"T1285"},{"id":"R915","pred":"themeOf","subj":"T1282","obj":"T1286"},{"id":"R916","pred":"themeOf","subj":"T1283","obj":"T1287"},{"id":"R917","pred":"themeOf","subj":"T1288","obj":"T1289"},{"id":"R918","pred":"themeOf","subj":"T1289","obj":"T1290"},{"id":"R919","pred":"themeOf","subj":"T1289","obj":"T1291"},{"id":"R920","pred":"themeOf","subj":"T1292","obj":"T1293"},{"id":"R921","pred":"themeOf","subj":"T1293","obj":"T1294"},{"id":"R922","pred":"themeOf","subj":"T1294","obj":"T1295"},{"id":"R923","pred":"themeOf","subj":"T1296","obj":"T1299"},{"id":"R924","pred":"themeOf","subj":"T1298","obj":"T1300"},{"id":"R925","pred":"themeOf","subj":"T1300","obj":"T1301"},{"id":"R926","pred":"themeOf","subj":"T1302","obj":"T1305"},{"id":"R927","pred":"themeOf","subj":"T1306","obj":"T1307"},{"id":"R928","pred":"themeOf","subj":"T1306","obj":"T1308"},{"id":"R929","pred":"themeOf","subj":"T1307","obj":"T1309"},{"id":"R930","pred":"themeOf","subj":"T1310","obj":"T1313"},{"id":"R931","pred":"themeOf","subj":"T1311","obj":"T1314"},{"id":"R932","pred":"themeOf","subj":"T1312","obj":"T1315"},{"id":"R933","pred":"themeOf","subj":"T1314","obj":"T1316"},{"id":"R934","pred":"themeOf","subj":"T1317","obj":"T1322"},{"id":"R935","pred":"themeOf","subj":"T1318","obj":"T1323"},{"id":"R936","pred":"themeOf","subj":"T1319","obj":"T1324"},{"id":"R937","pred":"themeOf","subj":"T1320","obj":"T1325"},{"id":"R938","pred":"themeOf","subj":"T1321","obj":"T1326"},{"id":"R939","pred":"causeOf","subj":"T1325","obj":"T1327"},{"id":"R940","pred":"themeOf","subj":"T1326","obj":"T1327"}],"text":"Results\nPhorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1. The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli. AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter. In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation. Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli. In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10. Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment. Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration. Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression."}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T87","span":{"begin":301,"end":314},"obj":"Positive_regulation"},{"id":"T88","span":{"begin":301,"end":314},"obj":"Positive_regulation"},{"id":"T89","span":{"begin":301,"end":314},"obj":"Positive_regulation"},{"id":"T90","span":{"begin":332,"end":337},"obj":"Protein"},{"id":"T91","span":{"begin":378,"end":382},"obj":"Protein"},{"id":"T92","span":{"begin":387,"end":391},"obj":"Protein"},{"id":"T93","span":{"begin":493,"end":498},"obj":"Protein"},{"id":"T94","span":{"begin":508,"end":516},"obj":"Regulation"},{"id":"T95","span":{"begin":547,"end":561},"obj":"Negative_regulation"},{"id":"T96","span":{"begin":1107,"end":1112},"obj":"Protein"},{"id":"T97","span":{"begin":1191,"end":1196},"obj":"Protein"},{"id":"T98","span":{"begin":1218,"end":1227},"obj":"Negative_regulation"},{"id":"T99","span":{"begin":1311,"end":1321},"obj":"Negative_regulation"},{"id":"T100","span":{"begin":1325,"end":1329},"obj":"Protein"},{"id":"T101","span":{"begin":1330,"end":1340},"obj":"Gene_expression"},{"id":"T102","span":{"begin":1347,"end":1352},"obj":"Protein"},{"id":"T103","span":{"begin":1365,"end":1374},"obj":"Negative_regulation"},{"id":"T104","span":{"begin":1482,"end":1492},"obj":"Negative_regulation"},{"id":"T105","span":{"begin":1482,"end":1492},"obj":"Negative_regulation"},{"id":"T106","span":{"begin":1498,"end":1503},"obj":"Protein"},{"id":"T107","span":{"begin":1508,"end":1512},"obj":"Protein"},{"id":"T108","span":{"begin":1543,"end":1552},"obj":"Negative_regulation"},{"id":"T109","span":{"begin":1553,"end":1558},"obj":"Protein"},{"id":"T110","span":{"begin":1559,"end":1569},"obj":"Gene_expression"}],"relations":[{"id":"R54","pred":"themeOf","subj":"T97","obj":"T98"},{"id":"R55","pred":"themeOf","subj":"T100","obj":"T101"},{"id":"R947","pred":"themeOf","subj":"T101","obj":"T99"},{"id":"R948","pred":"themeOf","subj":"T102","obj":"T103"},{"id":"R949","pred":"themeOf","subj":"T106","obj":"T104"},{"id":"R950","pred":"themeOf","subj":"T107","obj":"T105"},{"id":"R951","pred":"themeOf","subj":"T109","obj":"T110"},{"id":"R952","pred":"themeOf","subj":"T110","obj":"T108"},{"id":"R49","pred":"themeOf","subj":"T90","obj":"T89"},{"id":"R50","pred":"themeOf","subj":"T91","obj":"T87"},{"id":"R51","pred":"themeOf","subj":"T92","obj":"T88"},{"id":"R52","pred":"themeOf","subj":"T93","obj":"T94"},{"id":"R53","pred":"themeOf","subj":"T93","obj":"T95"}],"attributes":[{"id":"M13","pred":"Negation","subj":"T94","obj":"true"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Results\nPhorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1. The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli. AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter. In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation. Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli. In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10. Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment. Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration. Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T932","span":{"begin":81,"end":85},"obj":"P05412"},{"id":"T933","span":{"begin":262,"end":266},"obj":"P05412"},{"id":"T934","span":{"begin":332,"end":337},"obj":"P10145"},{"id":"T935","span":{"begin":373,"end":376},"obj":"P01375"},{"id":"T936","span":{"begin":378,"end":382},"obj":"P60568"},{"id":"T937","span":{"begin":387,"end":391},"obj":"P05231"},{"id":"T938","span":{"begin":493,"end":498},"obj":"P22301"},{"id":"T939","span":{"begin":577,"end":581},"obj":"P05412"},{"id":"T940","span":{"begin":1107,"end":1112},"obj":"O95999"},{"id":"T941","span":{"begin":1191,"end":1196},"obj":"O95999"},{"id":"T942","span":{"begin":1325,"end":1329},"obj":"P05231"},{"id":"T943","span":{"begin":1347,"end":1352},"obj":"P10145"},{"id":"T944","span":{"begin":1498,"end":1503},"obj":"P10145"},{"id":"T945","span":{"begin":1508,"end":1512},"obj":"P05231"},{"id":"T946","span":{"begin":1553,"end":1558},"obj":"P10145"},{"id":"T3757","span":{"begin":81,"end":85},"obj":"P05412"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Results\nPhorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1. The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli. AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter. In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation. Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli. In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10. Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment. Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration. Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression."}

{"project":"test2","denotations":[{"id":"T48","span":{"begin":301,"end":314},"obj":"Positive_regulation"},{"id":"T49","span":{"begin":332,"end":337},"obj":"Protein"},{"id":"T50","span":{"begin":378,"end":382},"obj":"Protein"},{"id":"T51","span":{"begin":387,"end":391},"obj":"Protein"},{"id":"T52","span":{"begin":392,"end":401},"obj":"Positive_regulation"},{"id":"T53","span":{"begin":493,"end":498},"obj":"Protein"},{"id":"T54","span":{"begin":508,"end":516},"obj":"Regulation"},{"id":"T55","span":{"begin":547,"end":561},"obj":"Negative_regulation"},{"id":"T56","span":{"begin":1107,"end":1112},"obj":"Protein"},{"id":"T57","span":{"begin":1191,"end":1196},"obj":"Protein"},{"id":"T58","span":{"begin":1218,"end":1227},"obj":"Negative_regulation"},{"id":"T59","span":{"begin":1311,"end":1321},"obj":"Negative_regulation"},{"id":"T60","span":{"begin":1325,"end":1329},"obj":"Protein"},{"id":"T61","span":{"begin":1330,"end":1340},"obj":"Gene_expression"},{"id":"T62","span":{"begin":1347,"end":1352},"obj":"Protein"},{"id":"T63","span":{"begin":1365,"end":1374},"obj":"Negative_regulation"},{"id":"T64","span":{"begin":1472,"end":1481},"obj":"Negative_regulation"},{"id":"T65","span":{"begin":1482,"end":1492},"obj":"Negative_regulation"},{"id":"T66","span":{"begin":1498,"end":1503},"obj":"Protein"},{"id":"T67","span":{"begin":1508,"end":1512},"obj":"Protein"},{"id":"T68","span":{"begin":1523,"end":1532},"obj":"Negative_regulation"},{"id":"T69","span":{"begin":1543,"end":1552},"obj":"Negative_regulation"},{"id":"T70","span":{"begin":1553,"end":1558},"obj":"Protein"},{"id":"T71","span":{"begin":1559,"end":1569},"obj":"Gene_expression"}],"relations":[{"id":"R26","pred":"themeOf","subj":"T49","obj":"T48"},{"id":"R27","pred":"themeOf","subj":"T50","obj":"T48"},{"id":"R28","pred":"themeOf","subj":"T51","obj":"T48"},{"id":"R29","pred":"themeOf","subj":"T53","obj":"T54"},{"id":"R30","pred":"themeOf","subj":"T53","obj":"T55"},{"id":"R31","pred":"themeOf","subj":"T57","obj":"T58"},{"id":"R32","pred":"themeOf","subj":"T59","obj":"T63"},{"id":"R33","pred":"themeOf","subj":"T60","obj":"T61"},{"id":"R34","pred":"themeOf","subj":"T61","obj":"T63"},{"id":"R35","pred":"themeOf","subj":"T61","obj":"T59"},{"id":"R36","pred":"themeOf","subj":"T66","obj":"T68"},{"id":"R37","pred":"themeOf","subj":"T66","obj":"T65"},{"id":"R38","pred":"themeOf","subj":"T67","obj":"T65"},{"id":"R39","pred":"themeOf","subj":"T70","obj":"T71"},{"id":"R40","pred":"themeOf","subj":"T71","obj":"T69"}],"attributes":[{"id":"M10","pred":"Negation","subj":"T59","obj":"true"},{"id":"M8","pred":"Negation","subj":"T48","obj":"true"},{"id":"M9","pred":"Negation","subj":"T58","obj":"true"}],"text":"Results\nPhorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1. The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli. AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter. In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation. Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli. In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10. Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment. Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration. Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression."}