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PMC:2889865 / 603-2173 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T636 0-7 NN denotes Results
T637 8-15 NN denotes Phorbol
T638 16-25 NN denotes myristate
T639 26-33 NN denotes acetate
T640 34-35 -LRB- denotes (
T641 35-38 NN denotes PMA
T642 38-39 -RRB- denotes )
T643 40-48 NN denotes exposure
T644 49-57 VB denotes resulted
T645 58-60 IN denotes in
T646 61-63 DT denotes an
T647 64-77 NN denotes up-regulation
T648 78-80 IN denotes of
T649 81-85 NN denotes AP-1
T650 86-89 CC denotes and
T651 90-105 NN denotes down-regulation
T652 106-108 IN denotes of
T653 109-114 NN denotes NF-κB
T654 115-123 NN denotes activity
T655 123-124 -COMMA- denotes ,
T656 125-132 RB denotes however
T657 132-133 -COMMA- denotes ,
T658 134-142 NN denotes exposure
T659 143-145 TO denotes to
T660 146-150 NN denotes heat
T661 151-157 VB denotes killed
T662 158-159 -LRB- denotes (
T663 159-161 NN denotes HK
T664 161-162 -RRB- denotes )
T665 163-175 FW denotes Escherichia.
T666 176-180 FW denotes coli
T667 181-187 NN denotes MG1655
T668 188-196 VB denotes resulted
T669 197-199 IN denotes in
T670 200-201 DT denotes a
T671 202-216 JJ denotes dose-dependent
T672 217-225 NN denotes increase
T673 226-228 IN denotes in
T674 229-234 NN denotes NF-κB
T675 235-243 NN denotes activity
T676 244-251 IN denotes without
T677 252-261 VB denotes affecting
T678 262-266 NN denotes AP-1
T679 268-271 DT denotes The
T680 272-280 NN denotes cytokine
T681 281-288 NN denotes profile
T682 289-297 VB denotes revealed
T683 298-300 DT denotes an
T684 301-314 NN denotes up-regulation
T685 315-317 IN denotes of
T686 318-321 DT denotes the
T687 322-331 NN denotes chemokine
T688 332-337 NN denotes CXCL8
T689 338-341 CC denotes and
T690 342-345 DT denotes the
T691 346-362 JJ denotes pro-inflammatory
T692 363-372 NN denotes cytokines
T693 373-376 NN denotes TNF
T694 376-377 -COMMA- denotes ,
T695 378-382 NN denotes IL-2
T696 383-386 CC denotes and
T697 387-391 NN denotes IL-6
T698 392-401 VB denotes following
T699 402-411 NN denotes treatment
T700 412-416 IN denotes with
T701 417-421 CC denotes both
T702 422-425 NN denotes PMA
T703 426-429 CC denotes and
T704 430-432 NN denotes HK
T705 433-435 FW denotes E.
T706 436-440 FW denotes coli
T707 440-441 -COMMA- denotes ,
T708 442-447 IN denotes while
T709 448-451 DT denotes the
T710 452-458 NN denotes levels
T711 459-461 IN denotes of
T712 462-465 DT denotes the
T713 466-483 JJ denotes anti-inflammatory
T714 484-492 NN denotes cytokine
T715 493-498 NN denotes IL-10
T716 499-503 VB denotes were
T717 504-507 RB denotes not
T718 508-516 VB denotes affected
T719 517-519 IN denotes by
T720 520-523 NN denotes PMA
T721 524-527 CC denotes but
T722 528-532 VB denotes were
T723 533-546 RB denotes significantly
T724 547-561 VB denotes down-regulated
T725 562-564 IN denotes by
T726 565-567 NNP denotes HK
T727 568-570 NNP denotes E.
T728 571-575 FW denotes coli
T729 577-581 NN denotes AP-1
T730 582-592 NN denotes activation
T731 593-596 VB denotes was
T732 597-610 RB denotes significantly
T733 611-620 VB denotes increased
T734 621-622 CD denotes 2
T735 623-624 NN denotes h
T736 625-630 IN denotes after
T737 631-634 NN denotes PMA
T738 635-643 NN denotes exposure
T739 644-647 CC denotes and
T740 648-657 VB denotes continued
T741 658-660 TO denotes to
T742 661-669 VB denotes increase
T743 670-680 RB denotes thereafter
T744 682-684 IN denotes In
T745 685-693 NN denotes contrast
T746 693-694 -COMMA- denotes ,
T747 695-700 NN denotes NF-κB
T748 701-710 VB denotes responded
T749 711-713 TO denotes to
T750 714-717 NN denotes PMA
T751 718-726 NN denotes exposure
T752 727-729 IN denotes by
T753 730-731 DT denotes a
T754 732-737 JJ denotes rapid
T755 738-751 NN denotes up-regulation
T756 752-760 VB denotes followed
T757 761-763 IN denotes by
T758 764-765 DT denotes a
T759 766-776 JJ denotes subsequent
T760 777-792 NN denotes down-regulation
T761 794-803 VB denotes Increased
T762 804-817 JJ denotes intracellular
T763 818-822 NN denotes Ca2+
T764 823-837 NN denotes concentrations
T765 838-847 VB denotes countered
T766 848-851 DT denotes the
T767 852-867 NN denotes down-regulation
T768 868-870 IN denotes of
T769 871-876 NN denotes NF-κB
T770 877-879 IN denotes by
T771 880-883 NN denotes PMA
T772 883-884 -COMMA- denotes ,
T773 885-890 IN denotes while
T774 891-898 JJ denotes similar
T775 899-908 NN denotes treatment
T776 909-913 IN denotes with
T777 914-921 NN denotes calcium
T778 922-931 NN denotes ionophore
T779 932-940 VB denotes resulted
T780 941-943 IN denotes in
T781 944-945 DT denotes a
T782 946-953 VB denotes reduced
T783 954-959 NN denotes NF-κB
T784 960-968 NN denotes activity
T785 969-978 VB denotes following
T786 979-988 NN denotes induction
T787 989-993 IN denotes with
T788 994-996 NN denotes HK
T789 997-999 FW denotes E.
T790 1000-1004 FW denotes coli
T791 1006-1008 IN denotes In
T792 1009-1014 NN denotes order
T793 1015-1017 TO denotes to
T794 1018-1025 JJ denotes further
T795 1026-1031 NN denotes study
T796 1032-1037 NN denotes NF-κB
T797 1038-1048 NN denotes activation
T798 1048-1049 -COMMA- denotes ,
T799 1050-1052 PRP denotes we
T800 1053-1063 VB denotes considered
T801 1064-1067 CD denotes two
T802 1068-1077 JJ denotes up-stream
T803 1078-1088 NN denotes signalling
T804 1089-1097 NN denotes proteins
T805 1097-1098 -COMMA- denotes ,
T806 1099-1102 NN denotes PKC
T807 1103-1106 CC denotes and
T808 1107-1112 NN denotes Bcl10
T809 1114-1132 NN denotes Phosphorylated-PKC
T810 1133-1139 NN denotes levels
T811 1140-1149 VB denotes increased
T812 1150-1152 IN denotes in
T813 1153-1161 NN denotes response
T814 1162-1164 TO denotes to
T815 1165-1168 NN denotes PMA
T816 1169-1172 CC denotes and
T817 1173-1175 NN denotes HK
T818 1176-1178 FW denotes E.
T819 1179-1183 FW denotes coli
T820 1183-1184 -COMMA- denotes ,
T821 1185-1190 IN denotes while
T822 1191-1196 NN denotes Bcl10
T823 1197-1203 NN denotes levels
T824 1204-1217 RB denotes significantly
T825 1218-1227 VB denotes decreased
T826 1228-1237 VB denotes following
T827 1238-1241 NN denotes PMA
T828 1242-1251 NN denotes treatment
T829 1253-1258 VB denotes Using
T830 1259-1261 DT denotes an
T831 1262-1267 NN denotes NF-κB
T832 1268-1278 NN denotes activation
T833 1279-1288 NN denotes inhibitor
T834 1288-1289 -COMMA- denotes ,
T835 1290-1292 PRP denotes we
T836 1293-1301 VB denotes observed
T837 1302-1310 JJ denotes complete
T838 1311-1321 NN denotes inhibition
T839 1322-1324 IN denotes of
T840 1325-1329 NN denotes IL-6
T841 1330-1340 NN denotes expression
T842 1341-1346 IN denotes while
T843 1347-1352 NN denotes CXCL8
T844 1353-1359 NN denotes levels
T845 1360-1364 RB denotes only
T846 1365-1374 VB denotes decreased
T847 1375-1377 IN denotes by
T848 1378-1380 CD denotes 40
T849 1380-1381 NN denotes %
T850 1382-1384 IN denotes at
T851 1385-1388 DT denotes the
T852 1389-1396 JJ denotes highest
T853 1397-1410 NN denotes concentration
T854 1412-1421 NN denotes Treatment
T855 1422-1424 IN denotes of
T856 1425-1431 NN denotes Jurkat
T857 1432-1439 NN denotes T-cells
T858 1440-1444 IN denotes with
T859 1445-1448 NN denotes PMA
T860 1449-1451 IN denotes in
T861 1452-1455 DT denotes the
T862 1456-1464 NN denotes presence
T863 1465-1467 IN denotes of
T864 1468-1481 NN denotes JNK-inhibitor
T865 1482-1492 VB denotes suppressed
T866 1493-1497 CC denotes both
T867 1498-1503 NN denotes CXCL8
T868 1504-1507 CC denotes and
T869 1508-1512 NN denotes IL-6
T870 1513-1518 IN denotes while
T871 1519-1532 NN denotes PKC-inhibitor
T872 1533-1542 RB denotes primarily
T873 1543-1552 VB denotes decreased
T874 1553-1558 NN denotes CXCL8
T875 1559-1569 NN denotes expression
T3418 67-77 NN denotes regulation
T3419 78-80 IN denotes of
T3420 81-85 NN denotes AP-1
T3421 86-89 CC denotes and
R522 T639 T637 arg1Of acetate,Phorbol
R523 T639 T638 arg1Of acetate,myristate
R524 T639 T640 arg1Of acetate,(
R525 T641 T640 arg2Of PMA,(
R526 T642 T640 arg3Of ),(
R527 T643 T639 arg1Of exposure,acetate
R528 T643 T644 arg1Of exposure,resulted
R529 T644 T645 arg1Of resulted,in
R530 T644 T655 arg1Of resulted,","
R531 T644 T656 arg1Of resulted,however
R532 T644 T657 arg1Of resulted,","
R533 T647 T645 arg2Of up-regulation,in
R534 T647 T646 arg1Of up-regulation,an
R535 T647 T648 arg1Of up-regulation,of
R536 T649 T650 arg1Of AP-1,and
R537 T650 T648 arg2Of and,of
R538 T650 T652 arg1Of and,of
R539 T651 T650 arg2Of down-regulation,and
R540 T654 T652 arg2Of activity,of
R541 T654 T653 arg1Of activity,NF-κB
R542 T657 T676 arg1Of ",",without
R543 T658 T659 arg1Of exposure,to
R544 T658 T668 arg1Of exposure,resulted
R545 T660 T661 arg2Of heat,killed
R546 T661 T662 arg1Of killed,(
R547 T663 T662 arg2Of HK,(
R548 T664 T662 arg3Of ),(
R549 T667 T659 arg2Of MG1655,to
R550 T667 T660 arg1Of MG1655,heat
R551 T667 T665 arg1Of MG1655,Escherichia.
R552 T667 T666 arg1Of MG1655,coli
R553 T668 T657 arg2Of resulted,","
R554 T668 T669 arg1Of resulted,in
R555 T672 T669 arg2Of increase,in
R556 T672 T670 arg1Of increase,a
R557 T672 T671 arg1Of increase,dose-dependent
R558 T672 T673 arg1Of increase,in
R559 T675 T673 arg2Of activity,in
R560 T675 T674 arg1Of activity,NF-κB
R561 T677 T676 arg2Of affecting,without
R562 T678 T677 arg2Of AP-1,affecting
R563 T681 T679 arg1Of profile,The
R564 T681 T680 arg1Of profile,cytokine
R565 T681 T682 arg1Of profile,revealed
R566 T682 T698 arg1Of revealed,following
R567 T682 T707 arg1Of revealed,","
R568 T682 T708 arg1Of revealed,while
R569 T684 T683 arg1Of up-regulation,an
R570 T684 T685 arg1Of up-regulation,of
R571 T684 T689 arg1Of up-regulation,and
R572 T688 T685 arg2Of CXCL8,of
R573 T688 T686 arg1Of CXCL8,the
R574 T688 T687 arg1Of CXCL8,chemokine
R575 T689 T682 arg2Of and,revealed
R576 T692 T690 arg1Of cytokines,the
R577 T692 T691 arg1Of cytokines,pro-inflammatory
R578 T693 T694 arg1Of TNF,","
R579 T694 T696 arg1Of ",",and
R580 T695 T694 arg2Of IL-2,","
R581 T696 T689 arg2Of and,and
R582 T696 T692 arg1Of and,cytokines
R583 T697 T696 arg2Of IL-6,and
R584 T699 T698 arg2Of treatment,following
R585 T699 T700 arg1Of treatment,with
R586 T702 T703 arg1Of PMA,and
R587 T703 T700 arg2Of and,with
R588 T703 T701 arg1Of and,both
R589 T703 T706 arg1Of and,coli
R590 T704 T703 arg2Of HK,and
R591 T706 T705 arg1Of coli,E.
R592 T710 T709 arg1Of levels,the
R593 T710 T711 arg1Of levels,of
R594 T710 T716 arg1Of levels,were
R595 T710 T718 arg2Of levels,affected
R596 T710 T722 arg1Of levels,were
R597 T710 T724 arg2Of levels,down-regulated
R598 T715 T711 arg2Of IL-10,of
R599 T715 T712 arg1Of IL-10,the
R600 T715 T713 arg1Of IL-10,anti-inflammatory
R601 T715 T714 arg1Of IL-10,cytokine
R602 T718 T716 arg2Of affected,were
R603 T718 T717 arg1Of affected,not
R604 T718 T721 arg1Of affected,but
R605 T720 T718 arg1Of PMA,affected
R606 T720 T719 arg2Of PMA,by
R607 T721 T708 arg2Of but,while
R608 T724 T721 arg2Of down-regulated,but
R609 T724 T722 arg2Of down-regulated,were
R610 T724 T723 arg1Of down-regulated,significantly
R611 T727 T724 arg1Of E.,down-regulated
R612 T727 T725 arg2Of E.,by
R613 T727 T726 arg1Of E.,HK
R614 T727 T728 arg1Of E.,coli
R615 T730 T729 arg1Of activation,AP-1
R616 T730 T731 arg1Of activation,was
R617 T730 T733 arg2Of activation,increased
R618 T730 T740 arg1Of activation,continued
R619 T730 T742 arg1Of activation,increase
R620 T733 T731 arg2Of increased,was
R621 T733 T732 arg1Of increased,significantly
R622 T733 T736 arg1Of increased,after
R623 T733 T739 arg1Of increased,and
R624 T735 T734 arg1Of h,2
R625 T736 T735 arg1Of after,h
R626 T738 T736 arg2Of exposure,after
R627 T738 T737 arg1Of exposure,PMA
R628 T740 T739 arg2Of continued,and
R629 T742 T740 arg2Of increase,continued
R630 T742 T741 arg1Of increase,to
R631 T742 T743 arg1Of increase,thereafter
R632 T745 T744 arg2Of contrast,In
R633 T747 T748 arg1Of NF-κB,responded
R634 T748 T744 arg1Of responded,In
R635 T748 T746 arg1Of responded,","
R636 T748 T749 arg1Of responded,to
R637 T748 T752 arg1Of responded,by
R638 T751 T749 arg2Of exposure,to
R639 T751 T750 arg1Of exposure,PMA
R640 T755 T752 arg2Of up-regulation,by
R641 T755 T753 arg1Of up-regulation,a
R642 T755 T754 arg1Of up-regulation,rapid
R643 T755 T756 arg2Of up-regulation,followed
R644 T760 T756 arg1Of down-regulation,followed
R645 T760 T757 arg2Of down-regulation,by
R646 T760 T758 arg1Of down-regulation,a
R647 T760 T759 arg1Of down-regulation,subsequent
R648 T764 T761 arg2Of concentrations,Increased
R649 T764 T762 arg1Of concentrations,intracellular
R650 T764 T763 arg1Of concentrations,Ca2+
R651 T764 T765 arg1Of concentrations,countered
R652 T765 T772 arg1Of countered,","
R653 T765 T773 arg1Of countered,while
R654 T767 T765 arg2Of down-regulation,countered
R655 T767 T766 arg1Of down-regulation,the
R656 T767 T768 arg1Of down-regulation,of
R657 T767 T770 arg1Of down-regulation,by
R658 T769 T768 arg2Of NF-κB,of
R659 T771 T770 arg2Of PMA,by
R660 T775 T774 arg1Of treatment,similar
R661 T775 T776 arg1Of treatment,with
R662 T775 T779 arg1Of treatment,resulted
R663 T778 T776 arg2Of ionophore,with
R664 T778 T777 arg1Of ionophore,calcium
R665 T779 T773 arg2Of resulted,while
R666 T779 T780 arg1Of resulted,in
R667 T784 T780 arg2Of activity,in
R668 T784 T781 arg1Of activity,a
R669 T784 T782 arg2Of activity,reduced
R670 T784 T783 arg1Of activity,NF-κB
R671 T784 T785 arg1Of activity,following
R672 T786 T785 arg2Of induction,following
R673 T786 T787 arg1Of induction,with
R674 T790 T787 arg2Of coli,with
R675 T790 T788 arg1Of coli,HK
R676 T790 T789 arg1Of coli,E.
R677 T791 T793 arg1Of In,to
R678 T792 T791 arg2Of order,In
R679 T797 T791 arg3Of activation,In
R680 T797 T794 arg1Of activation,further
R681 T797 T795 arg1Of activation,study
R682 T797 T796 arg1Of activation,NF-κB
R683 T799 T800 arg1Of we,considered
R684 T800 T791 arg1Of considered,In
R685 T800 T798 arg1Of considered,","
R686 T804 T800 arg2Of proteins,considered
R687 T804 T801 arg1Of proteins,two
R688 T804 T802 arg1Of proteins,up-stream
R689 T804 T803 arg1Of proteins,signalling
R690 T804 T805 arg1Of proteins,","
R691 T806 T807 arg1Of PKC,and
R692 T807 T805 arg2Of and,","
R693 T808 T807 arg2Of Bcl10,and
R694 T810 T809 arg1Of levels,Phosphorylated-PKC
R695 T810 T811 arg1Of levels,increased
R696 T811 T812 arg1Of increased,in
R697 T811 T820 arg1Of increased,","
R698 T811 T821 arg1Of increased,while
R699 T813 T812 arg2Of response,in
R700 T813 T814 arg1Of response,to
R701 T815 T816 arg1Of PMA,and
R702 T816 T814 arg2Of and,to
R703 T817 T816 arg2Of HK,and
R704 T819 T812 arg3Of coli,in
R705 T819 T818 arg1Of coli,E.
R706 T823 T822 arg1Of levels,Bcl10
R707 T823 T825 arg1Of levels,decreased
R708 T825 T821 arg2Of decreased,while
R709 T825 T824 arg1Of decreased,significantly
R710 T825 T826 arg1Of decreased,following
R711 T828 T826 arg2Of treatment,following
R712 T828 T827 arg1Of treatment,PMA
R713 T833 T829 arg2Of inhibitor,Using
R714 T833 T830 arg1Of inhibitor,an
R715 T833 T831 arg1Of inhibitor,NF-κB
R716 T833 T832 arg1Of inhibitor,activation
R717 T835 T829 arg1Of we,Using
R718 T835 T836 arg1Of we,observed
R719 T836 T829 modOf observed,Using
R720 T836 T834 arg1Of observed,","
R721 T836 T842 arg1Of observed,while
R722 T838 T836 arg2Of inhibition,observed
R723 T838 T837 arg1Of inhibition,complete
R724 T838 T839 arg1Of inhibition,of
R725 T841 T839 arg2Of expression,of
R726 T841 T840 arg1Of expression,IL-6
R727 T844 T843 arg1Of levels,CXCL8
R728 T844 T846 arg1Of levels,decreased
R729 T846 T842 arg2Of decreased,while
R730 T846 T845 arg1Of decreased,only
R731 T846 T847 arg1Of decreased,by
R732 T846 T850 arg1Of decreased,at
R733 T849 T847 arg2Of %,by
R734 T849 T848 arg1Of %,40
R735 T853 T850 arg2Of concentration,at
R736 T853 T851 arg1Of concentration,the
R737 T853 T852 arg1Of concentration,highest
R738 T854 T855 arg1Of Treatment,of
R739 T854 T858 arg1Of Treatment,with
R740 T854 T860 arg1Of Treatment,in
R741 T854 T865 arg1Of Treatment,suppressed
R742 T857 T855 arg2Of T-cells,of
R743 T857 T856 arg1Of T-cells,Jurkat
R744 T859 T858 arg2Of PMA,with
R745 T862 T860 arg2Of presence,in
R746 T862 T861 arg1Of presence,the
R747 T862 T863 arg1Of presence,of
R748 T864 T863 arg2Of JNK-inhibitor,of
R749 T865 T870 arg1Of suppressed,while
R750 T867 T868 arg1Of CXCL8,and
R751 T868 T865 arg2Of and,suppressed
R752 T868 T866 arg1Of and,both
R753 T869 T868 arg2Of IL-6,and
R754 T871 T873 arg1Of PKC-inhibitor,decreased
R755 T873 T870 arg2Of decreased,while
R756 T873 T872 arg1Of decreased,primarily
R757 T875 T873 arg2Of expression,decreased
R758 T875 T874 arg1Of expression,CXCL8
R2763 T3418 T3419 arg1Of regulation,of
R2764 T3420 T3421 arg1Of AP-1,and
R2765 T3421 T3419 arg2Of and,of

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T238 0-7 NNS denotes Results
T239 8-15 NNP denotes Phorbol
T240 16-25 NN denotes myristate
T241 26-33 NN denotes acetate
T242 34-35 -LRB- denotes (
T243 35-38 NNP denotes PMA
T244 38-39 -RRB- denotes )
T245 40-48 NN denotes exposure
T246 49-57 VBD denotes resulted
T247 58-60 IN denotes in
T248 61-63 DT denotes an
T249 64-77 NN denotes up-regulation
T250 78-80 IN denotes of
T251 81-85 NN denotes AP-1
T252 86-89 CC denotes and
T253 90-105 NN denotes down-regulation
T254 106-108 IN denotes of
T255 109-114 JJ denotes NF-κB
T256 115-123 NN denotes activity
T257 123-124 , denotes ,
T258 125-132 RB denotes however
T259 132-133 , denotes ,
T260 134-142 NN denotes exposure
T261 143-145 TO denotes to
T262 146-150 VB denotes heat
T263 151-157 VBN denotes killed
T264 158-159 -LRB- denotes (
T265 159-161 NNP denotes HK
T266 161-162 -RRB- denotes )
T267 163-174 NNP denotes Escherichia
T268 174-175 . denotes .
T269 176-180 NNS denotes coli
T270 181-187 NNS denotes MG1655
T271 188-196 VBD denotes resulted
T272 197-199 IN denotes in
T273 200-201 DT denotes a
T274 202-216 JJ denotes dose-dependent
T275 217-225 NN denotes increase
T276 226-228 IN denotes in
T277 229-234 JJ denotes NF-κB
T278 235-243 NN denotes activity
T279 244-251 IN denotes without
T280 252-261 VBG denotes affecting
T281 262-266 NN denotes AP-1
T282 266-267 . denotes .
T283 268-271 DT denotes The
T284 272-280 NN denotes cytokine
T285 281-288 NN denotes profile
T286 289-297 VBD denotes revealed
T287 298-300 DT denotes an
T288 301-314 NN denotes up-regulation
T289 315-317 IN denotes of
T290 318-321 DT denotes the
T291 322-331 NN denotes chemokine
T292 332-337 NNP denotes CXCL8
T293 338-341 CC denotes and
T294 342-345 DT denotes the
T295 346-362 JJ denotes pro-inflammatory
T296 363-372 NNS denotes cytokines
T297 373-376 NNP denotes TNF
T298 376-377 , denotes ,
T299 378-382 NNP denotes IL-2
T300 383-386 CC denotes and
T301 387-391 NNP denotes IL-6
T302 392-401 VBG denotes following
T303 402-411 NN denotes treatment
T304 412-416 IN denotes with
T305 417-421 DT denotes both
T306 422-425 NNP denotes PMA
T307 426-429 CC denotes and
T308 430-432 NNP denotes HK
T309 433-435 NNP denotes E.
T310 436-440 NNS denotes coli
T311 440-441 , denotes ,
T312 442-447 IN denotes while
T313 448-451 DT denotes the
T314 452-458 NNS denotes levels
T315 459-461 IN denotes of
T316 462-465 DT denotes the
T317 466-483 JJ denotes anti-inflammatory
T318 484-492 NN denotes cytokine
T319 493-498 NN denotes IL-10
T320 499-503 VBD denotes were
T321 504-507 RB denotes not
T322 508-516 VBN denotes affected
T323 517-519 IN denotes by
T324 520-523 NNP denotes PMA
T325 524-527 CC denotes but
T326 528-532 VBD denotes were
T327 533-546 RB denotes significantly
T328 547-561 VBN denotes down-regulated
T329 562-564 IN denotes by
T330 565-567 NNP denotes HK
T331 568-570 NNP denotes E.
T332 571-575 NNS denotes coli
T333 575-576 . denotes .
T334 577-581 CD denotes AP-1
T335 582-592 NN denotes activation
T336 593-596 VBD denotes was
T337 597-610 RB denotes significantly
T338 611-620 VBN denotes increased
T339 621-622 CD denotes 2
T340 623-624 NN denotes h
T341 625-630 IN denotes after
T342 631-634 NNP denotes PMA
T343 635-643 NN denotes exposure
T344 644-647 CC denotes and
T345 648-657 VBD denotes continued
T346 658-660 TO denotes to
T347 661-669 VB denotes increase
T348 670-680 RB denotes thereafter
T349 680-681 . denotes .
T350 682-684 IN denotes In
T351 685-693 NN denotes contrast
T352 693-694 , denotes ,
T353 695-700 NNP denotes NF-κB
T354 701-710 VBD denotes responded
T355 711-713 TO denotes to
T356 714-717 NNP denotes PMA
T357 718-726 NN denotes exposure
T358 877-879 IN denotes by
T359 727-729 IN denotes by
T360 730-731 DT denotes a
T361 732-737 JJ denotes rapid
T362 738-751 NN denotes up-regulation
T363 752-760 VBN denotes followed
T364 761-763 IN denotes by
T365 764-765 DT denotes a
T366 766-776 JJ denotes subsequent
T367 777-792 NN denotes down-regulation
T368 792-793 . denotes .
T369 794-803 VBN denotes Increased
T370 804-817 JJ denotes intracellular
T371 818-821 NNP denotes Ca2
T372 821-822 NN denotes +
T373 823-837 NNS denotes concentrations
T374 838-847 VBD denotes countered
T375 848-851 DT denotes the
T376 852-867 NN denotes down-regulation
T377 868-870 IN denotes of
T378 871-876 NN denotes NF-κB
T379 880-883 NNP denotes PMA
T380 883-884 , denotes ,
T381 885-890 IN denotes while
T382 891-898 JJ denotes similar
T383 899-908 NN denotes treatment
T384 909-913 IN denotes with
T385 914-921 NN denotes calcium
T386 922-931 NN denotes ionophore
T387 932-940 VBD denotes resulted
T388 941-943 IN denotes in
T389 944-945 DT denotes a
T390 946-953 VBN denotes reduced
T391 954-959 NN denotes NF-κB
T392 960-968 NN denotes activity
T393 969-978 VBG denotes following
T394 979-988 NN denotes induction
T395 989-993 IN denotes with
T396 994-996 NNP denotes HK
T397 997-999 NNP denotes E.
T398 1000-1004 NNS denotes coli
T399 1004-1005 . denotes .
T400 1006-1008 IN denotes In
T401 1009-1014 NN denotes order
T402 1015-1017 TO denotes to
T403 1018-1025 JJ denotes further
T404 1026-1031 NN denotes study
T405 1032-1037 NN denotes NF-κB
T406 1038-1048 NN denotes activation
T407 1048-1049 , denotes ,
T408 1050-1052 PRP denotes we
T409 1053-1063 VBD denotes considered
T410 1064-1067 CD denotes two
T411 1068-1077 JJ denotes up-stream
T412 1078-1088 JJ denotes signalling
T413 1089-1097 NNS denotes proteins
T414 1097-1098 , denotes ,
T415 1099-1102 NNP denotes PKC
T416 1103-1106 CC denotes and
T417 1107-1112 NNP denotes Bcl10
T418 1112-1113 . denotes .
T419 1114-1132 NN denotes Phosphorylated-PKC
T420 1133-1139 NNS denotes levels
T421 1140-1149 VBN denotes increased
T422 1150-1152 IN denotes in
T423 1153-1161 NN denotes response
T424 1162-1164 TO denotes to
T425 1165-1168 NNP denotes PMA
T426 1169-1172 CC denotes and
T427 1173-1175 NNP denotes HK
T428 1176-1178 NNP denotes E.
T429 1179-1183 NNS denotes coli
T430 1183-1184 , denotes ,
T431 1185-1190 IN denotes while
T432 1191-1196 JJ denotes Bcl10
T433 1197-1203 NNS denotes levels
T434 1204-1217 RB denotes significantly
T435 1218-1227 VBD denotes decreased
T436 1228-1237 VBG denotes following
T437 1238-1241 NNP denotes PMA
T438 1242-1251 NN denotes treatment
T439 1251-1252 . denotes .
T440 1253-1258 VBG denotes Using
T441 1259-1261 DT denotes an
T442 1262-1267 JJ denotes NF-κB
T443 1268-1278 NN denotes activation
T444 1279-1288 NN denotes inhibitor
T445 1288-1289 , denotes ,
T446 1290-1292 PRP denotes we
T447 1293-1301 VBD denotes observed
T448 1302-1310 JJ denotes complete
T449 1311-1321 NN denotes inhibition
T450 1322-1324 IN denotes of
T451 1325-1329 NN denotes IL-6
T452 1330-1340 NN denotes expression
T453 1341-1346 IN denotes while
T455 1353-1359 NNS denotes levels
T456 1360-1364 RB denotes only
T457 1365-1374 VBN denotes decreased
T458 1375-1377 IN denotes by
T459 1378-1380 CD denotes 40
T460 1380-1381 NN denotes %
T461 1382-1384 IN denotes at
T462 1385-1388 DT denotes the
T463 1389-1396 JJS denotes highest
T464 1397-1410 NN denotes concentration
T465 1410-1411 . denotes .
T466 1412-1421 NNP denotes Treatment
T467 1422-1424 IN denotes of
T468 1425-1431 NNP denotes Jurkat
T469 1432-1439 NNS denotes T-cells
T470 1440-1444 IN denotes with
T471 1445-1448 NNP denotes PMA
T472 1449-1451 IN denotes in
T473 1452-1455 DT denotes the
T474 1456-1464 NN denotes presence
T475 1465-1467 IN denotes of
T476 1468-1481 JJ denotes JNK-inhibitor
T477 1482-1492 VBN denotes suppressed
T478 1493-1497 DT denotes both
T479 1498-1503 NNP denotes CXCL8
T480 1504-1507 CC denotes and
T481 1508-1512 NNP denotes IL-6
T482 1513-1518 IN denotes while
T483 1519-1532 NNP denotes PKC-inhibitor
T484 1533-1542 RB denotes primarily
T485 1543-1552 VBD denotes decreased
T486 1553-1558 CD denotes CXCL8
T487 1559-1569 NN denotes expression
T488 1569-1570 . denotes .
T3064 67-77 NN denotes regulation
T3065 78-80 IN denotes of
T3066 81-85 NNP denotes AP-1
T3067 86-89 CC denotes and
T454 1347-1352 NNP denotes CXCL8
R128 T238 T246 nsubj Results,resulted
R129 T239 T241 nmod Phorbol,acetate
R130 T240 T241 compound myristate,acetate
R131 T241 T238 appos acetate,Results
R132 T242 T243 punct (,PMA
R133 T243 T241 appos PMA,acetate
R134 T244 T243 punct ),PMA
R135 T245 T246 nsubj exposure,resulted
R136 T246 T246 ROOT resulted,resulted
R137 T247 T246 prep in,resulted
R138 T248 T249 det an,up-regulation
R139 T249 T247 pobj up-regulation,in
R140 T250 T249 prep of,up-regulation
R141 T251 T250 pobj AP-1,of
R142 T252 T251 cc and,AP-1
R143 T253 T251 conj down-regulation,AP-1
R144 T254 T251 prep of,AP-1
R145 T255 T256 amod NF-κB,activity
R146 T256 T254 pobj activity,of
R147 T257 T246 punct ",",resulted
R148 T258 T259 preconj however,","
R149 T259 T246 punct ",",resulted
R150 T260 T267 nmod exposure,Escherichia
R151 T261 T267 prep to,Escherichia
R152 T262 T261 pobj heat,to
R153 T263 T262 dep killed,heat
R154 T264 T263 punct (,killed
R155 T265 T263 npadvmod HK,killed
R156 T266 T267 punct ),Escherichia
R157 T267 T246 dep Escherichia,resulted
R158 T268 T246 punct .,resulted
R159 T269 T270 compound coli,MG1655
R160 T270 T271 nsubj MG1655,resulted
R161 T271 T271 ROOT resulted,resulted
R162 T272 T271 prep in,resulted
R163 T273 T275 det a,increase
R164 T274 T275 amod dose-dependent,increase
R165 T275 T272 pobj increase,in
R166 T276 T275 prep in,increase
R167 T277 T278 amod NF-κB,activity
R168 T278 T276 pobj activity,in
R169 T279 T271 prep without,resulted
R170 T280 T279 pcomp affecting,without
R171 T281 T280 dobj AP-1,affecting
R172 T282 T271 punct .,resulted
R173 T283 T285 det The,profile
R174 T284 T285 compound cytokine,profile
R175 T285 T286 nsubj profile,revealed
R176 T286 T286 ROOT revealed,revealed
R177 T287 T288 det an,up-regulation
R178 T288 T286 dobj up-regulation,revealed
R179 T289 T288 prep of,up-regulation
R180 T290 T292 det the,CXCL8
R181 T291 T292 compound chemokine,CXCL8
R182 T292 T289 pobj CXCL8,of
R183 T293 T292 cc and,CXCL8
R184 T294 T296 det the,cytokines
R185 T295 T296 nsubj pro-inflammatory,cytokines
R186 T296 T292 conj cytokines,CXCL8
R187 T297 T296 conj TNF,cytokines
R188 T298 T297 punct ",",TNF
R189 T299 T297 conj IL-2,TNF
R190 T300 T299 cc and,IL-2
R191 T301 T299 conj IL-6,IL-2
R192 T302 T286 prep following,revealed
R193 T303 T302 pobj treatment,following
R194 T304 T303 prep with,treatment
R195 T305 T306 det both,PMA
R196 T306 T304 pobj PMA,with
R197 T307 T306 cc and,PMA
R198 T308 T310 compound HK,coli
R199 T309 T310 compound E.,coli
R200 T310 T306 conj coli,PMA
R201 T311 T286 punct ",",revealed
R202 T312 T322 mark while,affected
R203 T313 T314 det the,levels
R204 T314 T322 nsubjpass levels,affected
R205 T315 T314 prep of,levels
R206 T316 T319 det the,IL-10
R207 T317 T319 amod anti-inflammatory,IL-10
R208 T318 T319 compound cytokine,IL-10
R209 T319 T315 pobj IL-10,of
R210 T320 T322 auxpass were,affected
R211 T321 T322 neg not,affected
R212 T322 T286 advcl affected,revealed
R213 T323 T322 agent by,affected
R214 T324 T323 pobj PMA,by
R215 T325 T322 cc but,affected
R216 T326 T328 auxpass were,down-regulated
R217 T327 T328 advmod significantly,down-regulated
R218 T328 T322 conj down-regulated,affected
R219 T329 T328 agent by,down-regulated
R220 T330 T332 compound HK,coli
R221 T331 T332 compound E.,coli
R222 T332 T329 pobj coli,by
R223 T333 T286 punct .,revealed
R224 T334 T335 nummod AP-1,activation
R225 T335 T338 nsubjpass activation,increased
R226 T336 T338 auxpass was,increased
R227 T337 T338 advmod significantly,increased
R228 T338 T338 ROOT increased,increased
R229 T339 T340 nummod 2,h
R230 T340 T338 npadvmod h,increased
R231 T341 T338 prep after,increased
R232 T342 T343 compound PMA,exposure
R233 T343 T341 pobj exposure,after
R234 T344 T338 cc and,increased
R235 T345 T338 conj continued,increased
R236 T346 T347 aux to,increase
R237 T347 T345 xcomp increase,continued
R238 T348 T347 advmod thereafter,increase
R239 T349 T338 punct .,increased
R240 T350 T354 prep In,responded
R241 T351 T350 pobj contrast,In
R242 T352 T354 punct ",",responded
R243 T353 T354 nsubj NF-κB,responded
R244 T354 T354 ROOT responded,responded
R245 T355 T354 prep to,responded
R246 T356 T357 compound PMA,exposure
R247 T357 T355 pobj exposure,to
R248 T358 T376 prep by,down-regulation
R249 T359 T357 prep by,exposure
R250 T360 T362 det a,up-regulation
R251 T361 T362 amod rapid,up-regulation
R252 T362 T359 pobj up-regulation,by
R253 T363 T357 acl followed,exposure
R254 T364 T363 agent by,followed
R255 T365 T367 det a,down-regulation
R256 T366 T367 amod subsequent,down-regulation
R257 T367 T364 pobj down-regulation,by
R258 T368 T354 punct .,responded
R259 T369 T373 amod Increased,concentrations
R260 T370 T373 amod intracellular,concentrations
R261 T371 T373 compound Ca2,concentrations
R262 T372 T373 compound +,concentrations
R263 T373 T374 nsubj concentrations,countered
R264 T374 T374 ROOT countered,countered
R265 T375 T376 det the,down-regulation
R266 T376 T374 dobj down-regulation,countered
R267 T377 T376 prep of,down-regulation
R268 T378 T377 pobj NF-κB,of
R269 T379 T358 pobj PMA,by
R270 T380 T374 punct ",",countered
R271 T381 T387 mark while,resulted
R272 T382 T383 amod similar,treatment
R273 T383 T387 nsubj treatment,resulted
R274 T384 T383 prep with,treatment
R275 T385 T386 compound calcium,ionophore
R276 T386 T384 pobj ionophore,with
R277 T387 T374 advcl resulted,countered
R278 T388 T387 prep in,resulted
R279 T389 T392 det a,activity
R280 T390 T392 amod reduced,activity
R281 T391 T392 compound NF-κB,activity
R282 T392 T388 pobj activity,in
R283 T393 T392 acl following,activity
R284 T394 T393 pobj induction,following
R285 T395 T394 prep with,induction
R286 T396 T398 compound HK,coli
R287 T397 T398 compound E.,coli
R288 T398 T395 pobj coli,with
R289 T399 T374 punct .,countered
R290 T400 T409 prep In,considered
R291 T401 T400 pobj order,In
R292 T402 T404 aux to,study
R293 T403 T404 advmod further,study
R294 T404 T409 advcl study,considered
R295 T405 T406 compound NF-κB,activation
R296 T406 T404 dobj activation,study
R297 T407 T409 punct ",",considered
R298 T408 T409 nsubj we,considered
R299 T409 T409 ROOT considered,considered
R300 T410 T413 nummod two,proteins
R301 T411 T413 amod up-stream,proteins
R302 T412 T413 amod signalling,proteins
R303 T413 T409 dobj proteins,considered
R304 T414 T413 punct ",",proteins
R305 T415 T413 appos PKC,proteins
R306 T416 T415 cc and,PKC
R307 T417 T415 conj Bcl10,PKC
R308 T418 T409 punct .,considered
R309 T419 T420 compound Phosphorylated-PKC,levels
R310 T420 T421 nsubj levels,increased
R311 T421 T421 ROOT increased,increased
R312 T422 T421 prep in,increased
R313 T423 T422 pobj response,in
R314 T424 T423 prep to,response
R315 T425 T424 pobj PMA,to
R316 T426 T425 cc and,PMA
R317 T427 T429 compound HK,coli
R318 T428 T429 compound E.,coli
R319 T429 T425 conj coli,PMA
R320 T430 T421 punct ",",increased
R321 T431 T435 mark while,decreased
R322 T432 T433 compound Bcl10,levels
R323 T433 T435 nsubj levels,decreased
R324 T434 T435 advmod significantly,decreased
R325 T435 T421 advcl decreased,increased
R326 T436 T435 prep following,decreased
R327 T437 T438 compound PMA,treatment
R328 T438 T436 pobj treatment,following
R329 T439 T421 punct .,increased
R330 T440 T447 advcl Using,observed
R331 T441 T444 det an,inhibitor
R332 T442 T444 amod NF-κB,inhibitor
R333 T443 T444 compound activation,inhibitor
R334 T444 T440 dobj inhibitor,Using
R335 T445 T447 punct ",",observed
R336 T446 T447 nsubj we,observed
R337 T447 T447 ROOT observed,observed
R338 T448 T449 amod complete,inhibition
R339 T449 T447 dobj inhibition,observed
R340 T450 T449 prep of,inhibition
R341 T451 T452 amod IL-6,expression
R342 T452 T450 pobj expression,of
R343 T453 T457 mark while,decreased
R344 T455 T457 nsubj levels,decreased
R345 T456 T457 advmod only,decreased
R346 T457 T447 advcl decreased,observed
R347 T458 T457 prep by,decreased
R348 T459 T460 nummod 40,%
R349 T460 T458 pobj %,by
R350 T461 T457 prep at,decreased
R351 T462 T464 det the,concentration
R352 T463 T464 amod highest,concentration
R353 T464 T461 pobj concentration,at
R354 T465 T447 punct .,observed
R355 T466 T477 nsubj Treatment,suppressed
R356 T467 T466 prep of,Treatment
R357 T468 T469 compound Jurkat,T-cells
R358 T469 T467 pobj T-cells,of
R359 T470 T466 prep with,Treatment
R360 T471 T470 pobj PMA,with
R361 T472 T466 prep in,Treatment
R362 T473 T474 det the,presence
R363 T474 T472 pobj presence,in
R364 T475 T474 prep of,presence
R365 T476 T477 amod JNK-inhibitor,suppressed
R366 T477 T477 ROOT suppressed,suppressed
R367 T478 T479 preconj both,CXCL8
R368 T479 T477 dobj CXCL8,suppressed
R369 T480 T479 cc and,CXCL8
R370 T481 T479 conj IL-6,CXCL8
R371 T482 T485 mark while,decreased
R372 T483 T485 nsubj PKC-inhibitor,decreased
R373 T484 T485 advmod primarily,decreased
R374 T485 T477 advcl decreased,suppressed
R375 T486 T487 nummod CXCL8,expression
R376 T487 T485 dobj expression,decreased
R377 T488 T477 punct .,suppressed
R987 T454 T455 compound CXCL8,levels
R2410 T3065 T3064 prep of,regulation
R2411 T3066 T3065 pobj AP-1,of
R2412 T3067 T3066 cc and,AP-1

GO-BP

Id Subject Object Predicate Lexical cue
T971 67-77 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T972 95-105 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T973 304-314 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T974 741-751 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T975 782-792 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T976 857-867 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T987 301-331 http://purl.obolibrary.org/obo/GO_0032722 denotes up-regulation of the chemokine
T988 922-931 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T989 1032-1048 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T990 1262-1278 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T991 1078-1088 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T993 1099-1102 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T994 1129-1132 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T995 1519-1522 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T996 1153-1168 http://purl.obolibrary.org/obo/GO_1904627 denotes response to PMA
T997 1262-1288 http://purl.obolibrary.org/obo/GO_1903721 denotes NF-κB activation inhibitor
T998 1468-1471 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T3781 67-77 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

GO-MF

Id Subject Object Predicate Lexical cue
T1007 387-391 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1008 1325-1329 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1009 1508-1512 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1011 378-382 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T1012 493-498 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T1013 922-931 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T1014 1099-1102 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T1015 1129-1132 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T1016 1519-1522 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T1017 1468-1471 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK

GO-CC

Id Subject Object Predicate Lexical cue
T1020 1434-1439 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1022 804-817 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular

sentences

Id Subject Object Predicate Lexical cue
T124 0-7 Sentence denotes Results
T125 8-267 Sentence denotes Phorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1.
T126 268-576 Sentence denotes The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli.
T127 577-681 Sentence denotes AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter.
T128 682-793 Sentence denotes In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation.
T129 794-1005 Sentence denotes Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli.
T130 1006-1113 Sentence denotes In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10.
T131 1114-1252 Sentence denotes Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment.
T132 1253-1411 Sentence denotes Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration.
T133 1412-1570 Sentence denotes Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression.
T7 0-7 Sentence denotes Results
T8 8-267 Sentence denotes Phorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1.
T9 268-576 Sentence denotes The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli.
T10 577-681 Sentence denotes AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter.
T11 682-793 Sentence denotes In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation.
T12 794-1005 Sentence denotes Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli.
T13 1006-1113 Sentence denotes In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10.
T14 1114-1252 Sentence denotes Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment.
T15 1253-1411 Sentence denotes Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration.
T16 1412-1570 Sentence denotes Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression.

events-check-again

Id Subject Object Predicate Lexical cue Negation
T1220 301-314 Positive_regulation denotes up-regulation
T1221 301-314 Positive_regulation denotes up-regulation
T1222 301-314 Positive_regulation denotes up-regulation
T1223 332-337 Protein denotes CXCL8
T1224 378-382 Protein denotes IL-2
T1225 387-391 Protein denotes IL-6
T1226 493-498 Protein denotes IL-10
T1227 508-516 Regulation denotes affected true
T1228 547-561 Negative_regulation denotes down-regulated
T1229 1107-1112 Protein denotes Bcl10
T1230 1191-1196 Protein denotes Bcl10
T1231 1218-1227 Negative_regulation denotes decreased
T1232 1311-1321 Negative_regulation denotes inhibition
T1233 1325-1329 Protein denotes IL-6
T1234 1330-1340 Gene_expression denotes expression
T1235 1347-1352 Protein denotes CXCL8
T1236 1365-1374 Negative_regulation denotes decreased
T1237 1482-1492 Negative_regulation denotes suppressed
T1238 1482-1492 Negative_regulation denotes suppressed
T1239 1498-1503 Protein denotes CXCL8
T1240 1508-1512 Protein denotes IL-6
T1241 1543-1552 Negative_regulation denotes decreased
T1242 1553-1558 Protein denotes CXCL8
T1243 1559-1569 Gene_expression denotes expression
R881 T1223 T1222 themeOf CXCL8,up-regulation
R882 T1224 T1220 themeOf IL-2,up-regulation
R883 T1225 T1221 themeOf IL-6,up-regulation
R884 T1226 T1227 themeOf IL-10,affected
R885 T1226 T1228 themeOf IL-10,down-regulated
R886 T1230 T1231 themeOf Bcl10,decreased
R887 T1233 T1234 themeOf IL-6,expression
R888 T1234 T1232 themeOf expression,inhibition
R889 T1235 T1236 themeOf CXCL8,decreased
R890 T1239 T1237 themeOf CXCL8,suppressed
R891 T1240 T1238 themeOf IL-6,suppressed
R892 T1242 T1243 themeOf CXCL8,expression
R893 T1243 T1241 themeOf expression,decreased

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T1267 81-85 Protein denotes AP-1
T1268 109-114 Protein denotes NF-κB
T1269 229-234 Protein denotes NF-κB
T1270 262-266 Protein denotes AP-1
T1271 64-77 Positive_regulation denotes up-regulation
T1272 90-105 Negative_regulation denotes down-regulation
T1273 217-225 Positive_regulation denotes increase
T1274 252-261 Regulation denotes affecting
T1275 49-57 Positive_regulation denotes resulted
T1276 49-57 Positive_regulation denotes resulted
T1277 64-77 Positive_regulation denotes up-regulation
T1278 332-337 Protein denotes CXCL8
T1279 363-382 Protein denotes cytokines TNF, IL-2
T1280 387-391 Protein denotes IL-6
T1281 301-314 Positive_regulation denotes up-regulation
T1282 301-314 Positive_regulation denotes up-regulation
T1283 301-314 Positive_regulation denotes up-regulation
T1284 508-516 Regulation denotes affected
T1285 508-516 Regulation denotes affected
T1286 508-516 Regulation denotes affected
T1287 508-516 Regulation denotes affected
T1288 577-581 Protein denotes AP-1
T1289 582-592 Positive_regulation denotes activation
T1290 611-620 Positive_regulation denotes increased
T1291 661-669 Positive_regulation denotes increase
T1292 695-700 Protein denotes NF-κB
T1293 738-751 Positive_regulation denotes up-regulation
T1294 777-792 Negative_regulation denotes down-regulation
T1295 738-751 Positive_regulation denotes up-regulation
T1296 871-876 Protein denotes NF-κB
T1297 954-959 Protein denotes NF-κB
T1298 994-1004 Protein denotes HK E. coli
T1299 852-867 Negative_regulation denotes down-regulation
T1300 979-988 Positive_regulation denotes induction
T1301 946-953 Negative_regulation denotes reduced
T1302 1035-1037 Protein denotes κB
T1303 1099-1102 Protein denotes PKC
T1304 1107-1112 Protein denotes Bcl10
T1305 1038-1048 Positive_regulation denotes activation
T1306 1129-1132 Protein denotes PKC
T1307 1114-1128 Phosphorylation denotes Phosphorylated
T1308 1140-1149 Positive_regulation denotes increased
T1309 1140-1149 Positive_regulation denotes increased
T1310 1262-1267 Protein denotes NF-κB
T1311 1325-1329 Protein denotes IL-6
T1312 1347-1352 Protein denotes CXCL8
T1313 1279-1288 Negative_regulation denotes inhibitor
T1314 1330-1340 Gene_expression denotes expression
T1315 1365-1374 Negative_regulation denotes decreased
T1316 1311-1321 Negative_regulation denotes inhibition
T1317 1468-1471 Protein denotes JNK
T1318 1498-1503 Protein denotes CXCL8
T1319 1508-1512 Protein denotes IL-6
T1320 1519-1522 Protein denotes PKC
T1321 1553-1558 Protein denotes CXCL8
T1322 1472-1481 Negative_regulation denotes inhibitor
T1323 1482-1492 Negative_regulation denotes suppressed
T1324 1482-1492 Negative_regulation denotes suppressed
T1325 1523-1532 Negative_regulation denotes inhibitor
T1326 1559-1569 Gene_expression denotes expression
T1327 1543-1552 Negative_regulation denotes decreased
T3812 81-85 Protein denotes AP-1
T3816 67-77 Regulation denotes regulation
T3817 67-77 Regulation denotes regulation
R903 T1267 T1271 themeOf AP-1,up-regulation
R904 T1268 T1272 themeOf NF-κB,down-regulation
R905 T1269 T1273 themeOf NF-κB,increase
R906 T1270 T1274 themeOf AP-1,affecting
R907 T1271 T1275 themeOf up-regulation,resulted
R908 T1272 T1276 themeOf down-regulation,resulted
R909 T1272 T1277 themeOf down-regulation,up-regulation
R910 T1278 T1281 themeOf CXCL8,up-regulation
R911 T1279 T1282 themeOf "cytokines TNF, IL-2",up-regulation
R912 T1280 T1283 themeOf IL-6,up-regulation
R913 T1280 T1284 themeOf IL-6,affected
R914 T1281 T1285 themeOf up-regulation,affected
R915 T1282 T1286 themeOf up-regulation,affected
R916 T1283 T1287 themeOf up-regulation,affected
R917 T1288 T1289 themeOf AP-1,activation
R918 T1289 T1290 themeOf activation,increased
R919 T1289 T1291 themeOf activation,increase
R920 T1292 T1293 themeOf NF-κB,up-regulation
R921 T1293 T1294 themeOf up-regulation,down-regulation
R922 T1294 T1295 themeOf down-regulation,up-regulation
R923 T1296 T1299 themeOf NF-κB,down-regulation
R924 T1298 T1300 themeOf HK E. coli,induction
R925 T1300 T1301 themeOf induction,reduced
R926 T1302 T1305 themeOf κB,activation
R927 T1306 T1307 themeOf PKC,Phosphorylated
R928 T1306 T1308 themeOf PKC,increased
R929 T1307 T1309 themeOf Phosphorylated,increased
R930 T1310 T1313 themeOf NF-κB,inhibitor
R931 T1311 T1314 themeOf IL-6,expression
R932 T1312 T1315 themeOf CXCL8,decreased
R933 T1314 T1316 themeOf expression,inhibition
R934 T1317 T1322 themeOf JNK,inhibitor
R935 T1318 T1323 themeOf CXCL8,suppressed
R936 T1319 T1324 themeOf IL-6,suppressed
R937 T1320 T1325 themeOf PKC,inhibitor
R938 T1321 T1326 themeOf CXCL8,expression
R939 T1325 T1327 causeOf inhibitor,decreased
R940 T1326 T1327 themeOf expression,decreased

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation
T87 301-314 Positive_regulation denotes up-regulation
T88 301-314 Positive_regulation denotes up-regulation
T89 301-314 Positive_regulation denotes up-regulation
T90 332-337 Protein denotes CXCL8
T91 378-382 Protein denotes IL-2
T92 387-391 Protein denotes IL-6
T93 493-498 Protein denotes IL-10
T94 508-516 Regulation denotes affected true
T95 547-561 Negative_regulation denotes down-regulated
T96 1107-1112 Protein denotes Bcl10
T97 1191-1196 Protein denotes Bcl10
T98 1218-1227 Negative_regulation denotes decreased
T99 1311-1321 Negative_regulation denotes inhibition
T100 1325-1329 Protein denotes IL-6
T101 1330-1340 Gene_expression denotes expression
T102 1347-1352 Protein denotes CXCL8
T103 1365-1374 Negative_regulation denotes decreased
T104 1482-1492 Negative_regulation denotes suppressed
T105 1482-1492 Negative_regulation denotes suppressed
T106 1498-1503 Protein denotes CXCL8
T107 1508-1512 Protein denotes IL-6
T108 1543-1552 Negative_regulation denotes decreased
T109 1553-1558 Protein denotes CXCL8
T110 1559-1569 Gene_expression denotes expression
R54 T97 T98 themeOf Bcl10,decreased
R55 T100 T101 themeOf IL-6,expression
R947 T101 T99 themeOf expression,inhibition
R948 T102 T103 themeOf CXCL8,decreased
R949 T106 T104 themeOf CXCL8,suppressed
R950 T107 T105 themeOf IL-6,suppressed
R951 T109 T110 themeOf CXCL8,expression
R952 T110 T108 themeOf expression,decreased
R49 T90 T89 themeOf CXCL8,up-regulation
R50 T91 T87 themeOf IL-2,up-regulation
R51 T92 T88 themeOf IL-6,up-regulation
R52 T93 T94 themeOf IL-10,affected
R53 T93 T95 themeOf IL-10,down-regulated

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T932 81-85 P05412 denotes AP-1
T933 262-266 P05412 denotes AP-1
T934 332-337 P10145 denotes CXCL8
T935 373-376 P01375 denotes TNF
T936 378-382 P60568 denotes IL-2
T937 387-391 P05231 denotes IL-6
T938 493-498 P22301 denotes IL-10
T939 577-581 P05412 denotes AP-1
T940 1107-1112 O95999 denotes Bcl10
T941 1191-1196 O95999 denotes Bcl10
T942 1325-1329 P05231 denotes IL-6
T943 1347-1352 P10145 denotes CXCL8
T944 1498-1503 P10145 denotes CXCL8
T945 1508-1512 P05231 denotes IL-6
T946 1553-1558 P10145 denotes CXCL8
T3757 81-85 P05412 denotes AP-1

test2

Id Subject Object Predicate Lexical cue Negation
T48 301-314 Positive_regulation denotes up-regulation true
T49 332-337 Protein denotes CXCL8
T50 378-382 Protein denotes IL-2
T51 387-391 Protein denotes IL-6
T52 392-401 Positive_regulation denotes following
T53 493-498 Protein denotes IL-10
T54 508-516 Regulation denotes affected
T55 547-561 Negative_regulation denotes down-regulated
T56 1107-1112 Protein denotes Bcl10
T57 1191-1196 Protein denotes Bcl10
T58 1218-1227 Negative_regulation denotes decreased true
T59 1311-1321 Negative_regulation denotes inhibition true
T60 1325-1329 Protein denotes IL-6
T61 1330-1340 Gene_expression denotes expression
T62 1347-1352 Protein denotes CXCL8
T63 1365-1374 Negative_regulation denotes decreased
T64 1472-1481 Negative_regulation denotes inhibitor
T65 1482-1492 Negative_regulation denotes suppressed
T66 1498-1503 Protein denotes CXCL8
T67 1508-1512 Protein denotes IL-6
T68 1523-1532 Negative_regulation denotes inhibitor
T69 1543-1552 Negative_regulation denotes decreased
T70 1553-1558 Protein denotes CXCL8
T71 1559-1569 Gene_expression denotes expression
R26 T49 T48 themeOf CXCL8,up-regulation
R27 T50 T48 themeOf IL-2,up-regulation
R28 T51 T48 themeOf IL-6,up-regulation
R29 T53 T54 themeOf IL-10,affected
R30 T53 T55 themeOf IL-10,down-regulated
R31 T57 T58 themeOf Bcl10,decreased
R32 T59 T63 themeOf inhibition,decreased
R33 T60 T61 themeOf IL-6,expression
R34 T61 T63 themeOf expression,decreased
R35 T61 T59 themeOf expression,inhibition
R36 T66 T68 themeOf CXCL8,inhibitor
R37 T66 T65 themeOf CXCL8,suppressed
R38 T67 T65 themeOf IL-6,suppressed
R39 T70 T71 themeOf CXCL8,expression
R40 T71 T69 themeOf expression,decreased