PMC:2800179 / 25092-25765 JSONTXT

Annnotations TAB JSON ListView MergeView

    GO-MF

    {"project":"GO-MF","denotations":[{"id":"T17417","span":{"begin":501,"end":503},"obj":"http://purl.obolibrary.org/obo/GO_0003964"}],"text":"Degraded CGN Induce an Increase in ICAM-1 and TNF-α mRNA Expression\nThe increase in surface ICAM-1 expression and TNF-α production by monocytes correlated with an upregulation of mRNA for these molecules. Both 10 kDa and 40 kDa dCGN induced a robust increase in mRNA for both ICAM-1 and TNF-α (Fig. 6). β-actin mRNA levels were not affected by dCGN treatment.\n10.1371/journal.pone.0008666.g006 Figure 6 Degraded CGN stimulated ICAM-1 and TNF-α gene expression in monocytes.\nRepresentative samples of RT-PCR analysis showing over expression of ICAM-1 and TNF-α after stimulation of monocytes with 1 g/l of degraded CGN. β-actin expression was used as normalization gene.\n\nD"}

    GO-BP

    {"project":"GO-BP","denotations":[{"id":"T9778","span":{"begin":0,"end":8},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T9779","span":{"begin":114,"end":130},"obj":"http://purl.obolibrary.org/obo/GO_0032680"},{"id":"T9780","span":{"begin":114,"end":130},"obj":"http://purl.obolibrary.org/obo/GO_0032640"},{"id":"T17413","span":{"begin":404,"end":412},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T17414","span":{"begin":606,"end":614},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T17415","span":{"begin":445,"end":460},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T17416","span":{"begin":501,"end":503},"obj":"http://purl.obolibrary.org/obo/GO_0003964"}],"text":"Degraded CGN Induce an Increase in ICAM-1 and TNF-α mRNA Expression\nThe increase in surface ICAM-1 expression and TNF-α production by monocytes correlated with an upregulation of mRNA for these molecules. Both 10 kDa and 40 kDa dCGN induced a robust increase in mRNA for both ICAM-1 and TNF-α (Fig. 6). β-actin mRNA levels were not affected by dCGN treatment.\n10.1371/journal.pone.0008666.g006 Figure 6 Degraded CGN stimulated ICAM-1 and TNF-α gene expression in monocytes.\nRepresentative samples of RT-PCR analysis showing over expression of ICAM-1 and TNF-α after stimulation of monocytes with 1 g/l of degraded CGN. β-actin expression was used as normalization gene.\n\nD"}

    pmc-enju-pas

    {"project":"pmc-enju-pas","denotations":[{"id":"T9635","span":{"begin":0,"end":8},"obj":"VB"},{"id":"T9636","span":{"begin":9,"end":12},"obj":"NN"},{"id":"T9637","span":{"begin":13,"end":19},"obj":"VB"},{"id":"T9638","span":{"begin":20,"end":22},"obj":"DT"},{"id":"T9639","span":{"begin":23,"end":31},"obj":"NN"},{"id":"T9640","span":{"begin":32,"end":34},"obj":"IN"},{"id":"T9641","span":{"begin":35,"end":41},"obj":"NN"},{"id":"T9642","span":{"begin":42,"end":45},"obj":"CC"},{"id":"T9643","span":{"begin":46,"end":51},"obj":"NN"},{"id":"T9644","span":{"begin":52,"end":56},"obj":"NN"},{"id":"T9645","span":{"begin":57,"end":67},"obj":"NN"},{"id":"T9646","span":{"begin":68,"end":71},"obj":"DT"},{"id":"T9647","span":{"begin":72,"end":80},"obj":"NN"},{"id":"T9648","span":{"begin":81,"end":83},"obj":"IN"},{"id":"T9649","span":{"begin":84,"end":91},"obj":"NN"},{"id":"T9650","span":{"begin":92,"end":98},"obj":"NN"},{"id":"T9651","span":{"begin":99,"end":109},"obj":"NN"},{"id":"T9652","span":{"begin":110,"end":113},"obj":"CC"},{"id":"T9653","span":{"begin":114,"end":119},"obj":"NN"},{"id":"T9654","span":{"begin":120,"end":130},"obj":"NN"},{"id":"T9655","span":{"begin":131,"end":133},"obj":"IN"},{"id":"T9656","span":{"begin":134,"end":143},"obj":"NN"},{"id":"T9657","span":{"begin":144,"end":154},"obj":"VB"},{"id":"T9658","span":{"begin":155,"end":159},"obj":"IN"},{"id":"T9659","span":{"begin":160,"end":162},"obj":"DT"},{"id":"T9660","span":{"begin":163,"end":175},"obj":"NN"},{"id":"T9661","span":{"begin":176,"end":178},"obj":"IN"},{"id":"T9662","span":{"begin":179,"end":183},"obj":"NN"},{"id":"T9663","span":{"begin":184,"end":187},"obj":"IN"},{"id":"T9664","span":{"begin":188,"end":193},"obj":"DT"},{"id":"T9665","span":{"begin":194,"end":203},"obj":"NN"},{"id":"T9666","span":{"begin":205,"end":209},"obj":"DT"},{"id":"T9667","span":{"begin":210,"end":212},"obj":"CD"},{"id":"T9668","span":{"begin":213,"end":216},"obj":"NN"},{"id":"T9669","span":{"begin":217,"end":220},"obj":"CC"},{"id":"T9670","span":{"begin":221,"end":223},"obj":"CD"},{"id":"T9671","span":{"begin":224,"end":227},"obj":"NN"},{"id":"T9672","span":{"begin":228,"end":232},"obj":"NN"},{"id":"T9673","span":{"begin":233,"end":240},"obj":"VB"},{"id":"T9674","span":{"begin":241,"end":242},"obj":"DT"},{"id":"T9675","span":{"begin":243,"end":249},"obj":"JJ"},{"id":"T9676","span":{"begin":250,"end":258},"obj":"NN"},{"id":"T9677","span":{"begin":259,"end":261},"obj":"IN"},{"id":"T9678","span":{"begin":262,"end":266},"obj":"NN"},{"id":"T9679","span":{"begin":267,"end":270},"obj":"IN"},{"id":"T9680","span":{"begin":271,"end":275},"obj":"CC"},{"id":"T9681","span":{"begin":276,"end":282},"obj":"NN"},{"id":"T9682","span":{"begin":283,"end":286},"obj":"CC"},{"id":"T9683","span":{"begin":287,"end":292},"obj":"NN"},{"id":"T9684","span":{"begin":293,"end":294},"obj":"-LRB-"},{"id":"T9685","span":{"begin":294,"end":298},"obj":"NN"},{"id":"T9686","span":{"begin":299,"end":300},"obj":"CD"},{"id":"T9687","span":{"begin":300,"end":301},"obj":"-RRB-"},{"id":"T9688","span":{"begin":301,"end":308},"obj":"NN"},{"id":"T9689","span":{"begin":308,"end":312},"obj":"NN"},{"id":"T9690","span":{"begin":312,"end":318},"obj":"NN"},{"id":"T9691","span":{"begin":318,"end":322},"obj":"VB"},{"id":"T9692","span":{"begin":323,"end":326},"obj":"RB"},{"id":"T9693","span":{"begin":326,"end":334},"obj":"VB"},{"id":"T9694","span":{"begin":334,"end":336},"obj":"IN"},{"id":"T9695","span":{"begin":336,"end":340},"obj":"NN"},{"id":"T9696","span":{"begin":341,"end":350},"obj":"NN"},{"id":"T17323","span":{"begin":404,"end":412},"obj":"VB"},{"id":"T17324","span":{"begin":413,"end":416},"obj":"NN"},{"id":"T17325","span":{"begin":417,"end":427},"obj":"VB"},{"id":"T17326","span":{"begin":428,"end":434},"obj":"NN"},{"id":"T17327","span":{"begin":435,"end":438},"obj":"CC"},{"id":"T17328","span":{"begin":439,"end":444},"obj":"NN"},{"id":"T17329","span":{"begin":445,"end":449},"obj":"NN"},{"id":"T17330","span":{"begin":450,"end":460},"obj":"NN"},{"id":"T17331","span":{"begin":461,"end":463},"obj":"IN"},{"id":"T17332","span":{"begin":464,"end":473},"obj":"NN"},{"id":"T17333","span":{"begin":475,"end":489},"obj":"JJ"},{"id":"T17334","span":{"begin":490,"end":497},"obj":"NN"},{"id":"T17335","span":{"begin":498,"end":500},"obj":"IN"},{"id":"T17336","span":{"begin":501,"end":507},"obj":"NN"},{"id":"T17337","span":{"begin":508,"end":516},"obj":"NN"},{"id":"T17338","span":{"begin":517,"end":524},"obj":"VB"},{"id":"T17339","span":{"begin":525,"end":529},"obj":"IN"},{"id":"T17340","span":{"begin":530,"end":540},"obj":"NN"},{"id":"T17341","span":{"begin":541,"end":543},"obj":"IN"},{"id":"T17342","span":{"begin":544,"end":550},"obj":"NN"},{"id":"T17343","span":{"begin":551,"end":554},"obj":"CC"},{"id":"T17344","span":{"begin":555,"end":560},"obj":"NN"},{"id":"T17345","span":{"begin":561,"end":566},"obj":"IN"},{"id":"T17346","span":{"begin":567,"end":578},"obj":"NN"},{"id":"T17347","span":{"begin":579,"end":581},"obj":"IN"},{"id":"T17348","span":{"begin":582,"end":591},"obj":"NN"},{"id":"T17349","span":{"begin":592,"end":596},"obj":"IN"},{"id":"T17350","span":{"begin":597,"end":598},"obj":"CD"},{"id":"T17351","span":{"begin":599,"end":602},"obj":"NN"},{"id":"T17352","span":{"begin":603,"end":605},"obj":"IN"},{"id":"T17353","span":{"begin":606,"end":614},"obj":"VB"},{"id":"T17354","span":{"begin":615,"end":619},"obj":"NNP"},{"id":"T17355","span":{"begin":620,"end":627},"obj":"NN"},{"id":"T17356","span":{"begin":628,"end":638},"obj":"NN"},{"id":"T17357","span":{"begin":639,"end":642},"obj":"VB"},{"id":"T17358","span":{"begin":643,"end":647},"obj":"VB"},{"id":"T17359","span":{"begin":648,"end":650},"obj":"IN"},{"id":"T17360","span":{"begin":651,"end":664},"obj":"NN"},{"id":"T17361","span":{"begin":665,"end":669},"obj":"NN"}],"relations":[{"id":"R8446","pred":"arg2Of","subj":"T9636","obj":"T9635"},{"id":"R8447","pred":"arg1Of","subj":"T9636","obj":"T9637"},{"id":"R8448","pred":"arg2Of","subj":"T9639","obj":"T9637"},{"id":"R8449","pred":"arg1Of","subj":"T9639","obj":"T9638"},{"id":"R8450","pred":"arg1Of","subj":"T9639","obj":"T9640"},{"id":"R8451","pred":"arg1Of","subj":"T9641","obj":"T9642"},{"id":"R8452","pred":"arg2Of","subj":"T9642","obj":"T9640"},{"id":"R8453","pred":"arg2Of","subj":"T9645","obj":"T9642"},{"id":"R8454","pred":"arg1Of","subj":"T9645","obj":"T9643"},{"id":"R8455","pred":"arg1Of","subj":"T9645","obj":"T9644"},{"id":"R8456","pred":"arg1Of","subj":"T9647","obj":"T9646"},{"id":"R8457","pred":"arg1Of","subj":"T9647","obj":"T9648"},{"id":"R8458","pred":"arg1Of","subj":"T9647","obj":"T9657"},{"id":"R8459","pred":"arg1Of","subj":"T9651","obj":"T9649"},{"id":"R8460","pred":"arg1Of","subj":"T9651","obj":"T9650"},{"id":"R8461","pred":"arg1Of","subj":"T9651","obj":"T9652"},{"id":"R8462","pred":"arg2Of","subj":"T9652","obj":"T9648"},{"id":"R8463","pred":"arg1Of","subj":"T9652","obj":"T9655"},{"id":"R8464","pred":"arg2Of","subj":"T9654","obj":"T9652"},{"id":"R8465","pred":"arg1Of","subj":"T9654","obj":"T9653"},{"id":"R8466","pred":"arg2Of","subj":"T9656","obj":"T9655"},{"id":"R8467","pred":"arg1Of","subj":"T9657","obj":"T9658"},{"id":"R8468","pred":"arg2Of","subj":"T9660","obj":"T9658"},{"id":"R8469","pred":"arg1Of","subj":"T9660","obj":"T9659"},{"id":"R8470","pred":"arg1Of","subj":"T9660","obj":"T9661"},{"id":"R8471","pred":"arg2Of","subj":"T9662","obj":"T9661"},{"id":"R8472","pred":"arg1Of","subj":"T9662","obj":"T9663"},{"id":"R8473","pred":"arg2Of","subj":"T9665","obj":"T9663"},{"id":"R8474","pred":"arg1Of","subj":"T9665","obj":"T9664"},{"id":"R8475","pred":"arg1Of","subj":"T9668","obj":"T9669"},{"id":"R8476","pred":"arg1Of","subj":"T9669","obj":"T9667"},{"id":"R8477","pred":"arg2Of","subj":"T9670","obj":"T9669"},{"id":"R8478","pred":"arg1Of","subj":"T9672","obj":"T9666"},{"id":"R8479","pred":"arg1Of","subj":"T9672","obj":"T9668"},{"id":"R8480","pred":"arg1Of","subj":"T9672","obj":"T9670"},{"id":"R8481","pred":"arg1Of","subj":"T9672","obj":"T9671"},{"id":"R8482","pred":"arg1Of","subj":"T9672","obj":"T9673"},{"id":"R8483","pred":"arg2Of","subj":"T9676","obj":"T9673"},{"id":"R8484","pred":"arg1Of","subj":"T9676","obj":"T9674"},{"id":"R8485","pred":"arg1Of","subj":"T9676","obj":"T9675"},{"id":"R8486","pred":"arg1Of","subj":"T9676","obj":"T9677"},{"id":"R8487","pred":"arg1Of","subj":"T9676","obj":"T9679"},{"id":"R8488","pred":"arg2Of","subj":"T9678","obj":"T9677"},{"id":"R8489","pred":"arg1Of","subj":"T9681","obj":"T9682"},{"id":"R8490","pred":"arg2Of","subj":"T9682","obj":"T9679"},{"id":"R8491","pred":"arg1Of","subj":"T9682","obj":"T9680"},{"id":"R8492","pred":"arg2Of","subj":"T9683","obj":"T9682"},{"id":"R8493","pred":"arg2Of","subj":"T9685","obj":"T9684"},{"id":"R8494","pred":"arg1Of","subj":"T9685","obj":"T9686"},{"id":"R8495","pred":"arg3Of","subj":"T9687","obj":"T9684"},{"id":"R8496","pred":"arg1Of","subj":"T9690","obj":"T9684"},{"id":"R8497","pred":"arg1Of","subj":"T9690","obj":"T9688"},{"id":"R8498","pred":"arg1Of","subj":"T9690","obj":"T9689"},{"id":"R8499","pred":"arg1Of","subj":"T9690","obj":"T9691"},{"id":"R8500","pred":"arg2Of","subj":"T9690","obj":"T9693"},{"id":"R8501","pred":"arg3Of","subj":"T9693","obj":"T9673"},{"id":"R8502","pred":"arg2Of","subj":"T9693","obj":"T9691"},{"id":"R8503","pred":"arg1Of","subj":"T9693","obj":"T9692"},{"id":"R8504","pred":"arg1Of","subj":"T9696","obj":"T9693"},{"id":"R8505","pred":"arg2Of","subj":"T9696","obj":"T9694"},{"id":"R8506","pred":"arg1Of","subj":"T9696","obj":"T9695"},{"id":"R14828","pred":"arg2Of","subj":"T17324","obj":"T17323"},{"id":"R14829","pred":"arg1Of","subj":"T17324","obj":"T17325"},{"id":"R14830","pred":"arg1Of","subj":"T17326","obj":"T17327"},{"id":"R14831","pred":"arg2Of","subj":"T17327","obj":"T17325"},{"id":"R14832","pred":"arg1Of","subj":"T17327","obj":"T17331"},{"id":"R14833","pred":"arg2Of","subj":"T17330","obj":"T17327"},{"id":"R14834","pred":"arg1Of","subj":"T17330","obj":"T17328"},{"id":"R14835","pred":"arg1Of","subj":"T17330","obj":"T17329"},{"id":"R14836","pred":"arg2Of","subj":"T17332","obj":"T17331"},{"id":"R14837","pred":"arg1Of","subj":"T17334","obj":"T17333"},{"id":"R14838","pred":"arg1Of","subj":"T17334","obj":"T17335"},{"id":"R14839","pred":"arg1Of","subj":"T17334","obj":"T17357"},{"id":"R14840","pred":"arg2Of","subj":"T17334","obj":"T17358"},{"id":"R14841","pred":"arg2Of","subj":"T17337","obj":"T17335"},{"id":"R14842","pred":"arg1Of","subj":"T17337","obj":"T17336"},{"id":"R14843","pred":"arg1Of","subj":"T17337","obj":"T17338"},{"id":"R14844","pred":"arg1Of","subj":"T17338","obj":"T17339"},{"id":"R14845","pred":"arg1Of","subj":"T17338","obj":"T17345"},{"id":"R14846","pred":"arg2Of","subj":"T17340","obj":"T17339"},{"id":"R14847","pred":"arg1Of","subj":"T17340","obj":"T17341"},{"id":"R14848","pred":"arg1Of","subj":"T17342","obj":"T17343"},{"id":"R14849","pred":"arg2Of","subj":"T17343","obj":"T17341"},{"id":"R14850","pred":"arg2Of","subj":"T17344","obj":"T17343"},{"id":"R14851","pred":"arg2Of","subj":"T17346","obj":"T17345"},{"id":"R14852","pred":"arg1Of","subj":"T17346","obj":"T17347"},{"id":"R14853","pred":"arg1Of","subj":"T17346","obj":"T17349"},{"id":"R14854","pred":"arg2Of","subj":"T17348","obj":"T17347"},{"id":"R14855","pred":"arg2Of","subj":"T17351","obj":"T17349"},{"id":"R14856","pred":"arg1Of","subj":"T17351","obj":"T17350"},{"id":"R14857","pred":"arg1Of","subj":"T17351","obj":"T17352"},{"id":"R14858","pred":"arg2Of","subj":"T17356","obj":"T17352"},{"id":"R14859","pred":"arg2Of","subj":"T17356","obj":"T17353"},{"id":"R14860","pred":"arg1Of","subj":"T17356","obj":"T17354"},{"id":"R14861","pred":"arg1Of","subj":"T17356","obj":"T17355"},{"id":"R14862","pred":"arg2Of","subj":"T17358","obj":"T17357"},{"id":"R14863","pred":"arg1Of","subj":"T17358","obj":"T17359"},{"id":"R14864","pred":"arg2Of","subj":"T17361","obj":"T17359"},{"id":"R14865","pred":"arg1Of","subj":"T17361","obj":"T17360"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"Degraded CGN Induce an Increase in ICAM-1 and TNF-α mRNA Expression\nThe increase in surface ICAM-1 expression and TNF-α production by monocytes correlated with an upregulation of mRNA for these molecules. Both 10 kDa and 40 kDa dCGN induced a robust increase in mRNA for both ICAM-1 and TNF-α (Fig. 6). β-actin mRNA levels were not affected by dCGN treatment.\n10.1371/journal.pone.0008666.g006 Figure 6 Degraded CGN stimulated ICAM-1 and TNF-α gene expression in monocytes.\nRepresentative samples of RT-PCR analysis showing over expression of ICAM-1 and TNF-α after stimulation of monocytes with 1 g/l of degraded CGN. β-actin expression was used as normalization gene.\n\nD"}

    bionlp-st-ge-2016-coref

    {"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T9697","span":{"begin":188,"end":203},"obj":"Anaphor"},{"id":"T9698","span":{"begin":92,"end":98},"obj":"Antecedent"},{"id":"T9699","span":{"begin":114,"end":119},"obj":"Antecedent"}],"relations":[{"id":"R8507","pred":"boundBy","subj":"T9697","obj":"T9698"},{"id":"R8508","pred":"boundBy","subj":"T9697","obj":"T9699"}],"namespaces":[{"prefix":"_base","uri":"https://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Degraded CGN Induce an Increase in ICAM-1 and TNF-α mRNA Expression\nThe increase in surface ICAM-1 expression and TNF-α production by monocytes correlated with an upregulation of mRNA for these molecules. Both 10 kDa and 40 kDa dCGN induced a robust increase in mRNA for both ICAM-1 and TNF-α (Fig. 6). β-actin mRNA levels were not affected by dCGN treatment.\n10.1371/journal.pone.0008666.g006 Figure 6 Degraded CGN stimulated ICAM-1 and TNF-α gene expression in monocytes.\nRepresentative samples of RT-PCR analysis showing over expression of ICAM-1 and TNF-α after stimulation of monocytes with 1 g/l of degraded CGN. β-actin expression was used as normalization gene.\n\nD"}

    bionlp-st-ge-2016-spacy-parsed

    {"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T9710","span":{"begin":0,"end":8},"obj":"JJ"},{"id":"T9711","span":{"begin":9,"end":12},"obj":"NNP"},{"id":"T9712","span":{"begin":13,"end":19},"obj":"VB"},{"id":"T9713","span":{"begin":20,"end":22},"obj":"DT"},{"id":"T9714","span":{"begin":23,"end":31},"obj":"VB"},{"id":"T9715","span":{"begin":32,"end":34},"obj":"IN"},{"id":"T9716","span":{"begin":35,"end":41},"obj":"NNP"},{"id":"T9717","span":{"begin":42,"end":45},"obj":"CC"},{"id":"T9718","span":{"begin":46,"end":51},"obj":"NNP"},{"id":"T9719","span":{"begin":52,"end":56},"obj":"NNP"},{"id":"T9720","span":{"begin":57,"end":67},"obj":"NNP"},{"id":"T9721","span":{"begin":68,"end":71},"obj":"NNP"},{"id":"T9722","span":{"begin":72,"end":80},"obj":"NN"},{"id":"T9723","span":{"begin":81,"end":83},"obj":"IN"},{"id":"T9724","span":{"begin":84,"end":91},"obj":"NN"},{"id":"T9725","span":{"begin":92,"end":98},"obj":"NN"},{"id":"T9726","span":{"begin":99,"end":109},"obj":"NN"},{"id":"T9727","span":{"begin":110,"end":113},"obj":"CC"},{"id":"T9728","span":{"begin":114,"end":119},"obj":"JJ"},{"id":"T9729","span":{"begin":120,"end":130},"obj":"NN"},{"id":"T9730","span":{"begin":131,"end":133},"obj":"IN"},{"id":"T9731","span":{"begin":134,"end":143},"obj":"NNS"},{"id":"T9732","span":{"begin":144,"end":154},"obj":"VBN"},{"id":"T9733","span":{"begin":155,"end":159},"obj":"IN"},{"id":"T9734","span":{"begin":160,"end":162},"obj":"DT"},{"id":"T9735","span":{"begin":163,"end":175},"obj":"NN"},{"id":"T9736","span":{"begin":176,"end":178},"obj":"IN"},{"id":"T9737","span":{"begin":179,"end":183},"obj":"NNP"},{"id":"T9738","span":{"begin":184,"end":187},"obj":"IN"},{"id":"T9739","span":{"begin":188,"end":193},"obj":"DT"},{"id":"T9740","span":{"begin":194,"end":203},"obj":"NNS"},{"id":"T9741","span":{"begin":203,"end":204},"obj":"."},{"id":"T9742","span":{"begin":205,"end":209},"obj":"DT"},{"id":"T9743","span":{"begin":210,"end":212},"obj":"CD"},{"id":"T9744","span":{"begin":213,"end":216},"obj":"NN"},{"id":"T9745","span":{"begin":217,"end":220},"obj":"CC"},{"id":"T9746","span":{"begin":221,"end":223},"obj":"CD"},{"id":"T9747","span":{"begin":224,"end":227},"obj":"NNP"},{"id":"T9748","span":{"begin":228,"end":232},"obj":"NNP"},{"id":"T9749","span":{"begin":233,"end":240},"obj":"VBD"},{"id":"T9750","span":{"begin":241,"end":242},"obj":"DT"},{"id":"T9751","span":{"begin":243,"end":249},"obj":"JJ"},{"id":"T9752","span":{"begin":250,"end":258},"obj":"NN"},{"id":"T9753","span":{"begin":259,"end":261},"obj":"IN"},{"id":"T9754","span":{"begin":262,"end":266},"obj":"NNP"},{"id":"T9755","span":{"begin":267,"end":270},"obj":"IN"},{"id":"T9756","span":{"begin":271,"end":275},"obj":"DT"},{"id":"T9757","span":{"begin":276,"end":282},"obj":"NNP"},{"id":"T9758","span":{"begin":283,"end":286},"obj":"CC"},{"id":"T9759","span":{"begin":287,"end":292},"obj":"NNP"},{"id":"T9760","span":{"begin":293,"end":294},"obj":"-LRB-"},{"id":"T9761","span":{"begin":294,"end":298},"obj":"NNP"},{"id":"T9762","span":{"begin":299,"end":300},"obj":"CD"},{"id":"T9763","span":{"begin":300,"end":301},"obj":"-RRB-"},{"id":"T9764","span":{"begin":301,"end":302},"obj":"."},{"id":"T9765","span":{"begin":303,"end":310},"obj":"JJ"},{"id":"T9766","span":{"begin":311,"end":315},"obj":"NN"},{"id":"T9767","span":{"begin":316,"end":322},"obj":"NNS"},{"id":"T9768","span":{"begin":323,"end":327},"obj":"VBD"},{"id":"T9769","span":{"begin":328,"end":331},"obj":"RB"},{"id":"T9770","span":{"begin":332,"end":340},"obj":"VBN"},{"id":"T9771","span":{"begin":341,"end":343},"obj":"IN"},{"id":"T9772","span":{"begin":344,"end":348},"obj":"NNP"},{"id":"T9773","span":{"begin":349,"end":358},"obj":"NN"},{"id":"T9774","span":{"begin":358,"end":359},"obj":"."},{"id":"T17369","span":{"begin":404,"end":412},"obj":"JJ"},{"id":"T17370","span":{"begin":413,"end":416},"obj":"NNP"},{"id":"T17371","span":{"begin":417,"end":427},"obj":"VBD"},{"id":"T17372","span":{"begin":428,"end":434},"obj":"NNP"},{"id":"T17373","span":{"begin":435,"end":438},"obj":"CC"},{"id":"T17374","span":{"begin":439,"end":444},"obj":"NNP"},{"id":"T17375","span":{"begin":445,"end":449},"obj":"NN"},{"id":"T17376","span":{"begin":450,"end":460},"obj":"NN"},{"id":"T17377","span":{"begin":461,"end":463},"obj":"IN"},{"id":"T17378","span":{"begin":464,"end":473},"obj":"NNS"},{"id":"T17379","span":{"begin":473,"end":474},"obj":"."},{"id":"T17380","span":{"begin":475,"end":489},"obj":"NNP"},{"id":"T17381","span":{"begin":490,"end":497},"obj":"NNS"},{"id":"T17382","span":{"begin":498,"end":500},"obj":"IN"},{"id":"T17383","span":{"begin":501,"end":507},"obj":"NN"},{"id":"T17384","span":{"begin":508,"end":516},"obj":"NN"},{"id":"T17385","span":{"begin":517,"end":524},"obj":"VBG"},{"id":"T17386","span":{"begin":525,"end":529},"obj":"IN"},{"id":"T17387","span":{"begin":530,"end":540},"obj":"NN"},{"id":"T17388","span":{"begin":541,"end":543},"obj":"IN"},{"id":"T17389","span":{"begin":544,"end":550},"obj":"NNP"},{"id":"T17390","span":{"begin":551,"end":554},"obj":"CC"},{"id":"T17391","span":{"begin":555,"end":560},"obj":"NNP"},{"id":"T17392","span":{"begin":561,"end":566},"obj":"IN"},{"id":"T17393","span":{"begin":567,"end":578},"obj":"NN"},{"id":"T17394","span":{"begin":579,"end":581},"obj":"IN"},{"id":"T17395","span":{"begin":582,"end":591},"obj":"NNS"},{"id":"T17396","span":{"begin":592,"end":596},"obj":"IN"},{"id":"T17397","span":{"begin":597,"end":598},"obj":"CD"},{"id":"T17398","span":{"begin":599,"end":602},"obj":"NN"},{"id":"T17399","span":{"begin":603,"end":605},"obj":"IN"},{"id":"T17400","span":{"begin":606,"end":614},"obj":"JJ"},{"id":"T17401","span":{"begin":615,"end":618},"obj":"NNP"},{"id":"T17402","span":{"begin":618,"end":619},"obj":"."},{"id":"T17403","span":{"begin":620,"end":627},"obj":"JJ"},{"id":"T17404","span":{"begin":628,"end":638},"obj":"NN"},{"id":"T17405","span":{"begin":639,"end":642},"obj":"VBD"},{"id":"T17406","span":{"begin":643,"end":647},"obj":"VBN"},{"id":"T17407","span":{"begin":648,"end":650},"obj":"IN"},{"id":"T17408","span":{"begin":651,"end":664},"obj":"NN"},{"id":"T17409","span":{"begin":665,"end":669},"obj":"NN"},{"id":"T17410","span":{"begin":669,"end":670},"obj":"."}],"relations":[{"id":"R8509","pred":"amod","subj":"T9710","obj":"T9712"},{"id":"R8510","pred":"nsubj","subj":"T9711","obj":"T9712"},{"id":"R8511","pred":"ROOT","subj":"T9712","obj":"T9712"},{"id":"R8512","pred":"det","subj":"T9713","obj":"T9714"},{"id":"R8513","pred":"dobj","subj":"T9714","obj":"T9712"},{"id":"R8514","pred":"prep","subj":"T9715","obj":"T9714"},{"id":"R8515","pred":"pobj","subj":"T9716","obj":"T9715"},{"id":"R8516","pred":"cc","subj":"T9717","obj":"T9716"},{"id":"R8517","pred":"compound","subj":"T9718","obj":"T9719"},{"id":"R8518","pred":"compound","subj":"T9719","obj":"T9720"},{"id":"R8519","pred":"conj","subj":"T9720","obj":"T9716"},{"id":"R8520","pred":"det","subj":"T9721","obj":"T9722"},{"id":"R8521","pred":"dobj","subj":"T9722","obj":"T9712"},{"id":"R8522","pred":"prep","subj":"T9723","obj":"T9722"},{"id":"R8523","pred":"nmod","subj":"T9724","obj":"T9726"},{"id":"R8524","pred":"compound","subj":"T9725","obj":"T9726"},{"id":"R8525","pred":"pobj","subj":"T9726","obj":"T9723"},{"id":"R8526","pred":"cc","subj":"T9727","obj":"T9726"},{"id":"R8527","pred":"amod","subj":"T9728","obj":"T9729"},{"id":"R8528","pred":"conj","subj":"T9729","obj":"T9726"},{"id":"R8529","pred":"prep","subj":"T9730","obj":"T9722"},{"id":"R8530","pred":"pobj","subj":"T9731","obj":"T9730"},{"id":"R8531","pred":"acl","subj":"T9732","obj":"T9731"},{"id":"R8532","pred":"prep","subj":"T9733","obj":"T9732"},{"id":"R8533","pred":"det","subj":"T9734","obj":"T9735"},{"id":"R8534","pred":"pobj","subj":"T9735","obj":"T9733"},{"id":"R8535","pred":"prep","subj":"T9736","obj":"T9735"},{"id":"R8536","pred":"pobj","subj":"T9737","obj":"T9736"},{"id":"R8537","pred":"prep","subj":"T9738","obj":"T9735"},{"id":"R8538","pred":"det","subj":"T9739","obj":"T9740"},{"id":"R8539","pred":"pobj","subj":"T9740","obj":"T9738"},{"id":"R8540","pred":"punct","subj":"T9741","obj":"T9712"},{"id":"R8541","pred":"preconj","subj":"T9742","obj":"T9744"},{"id":"R8542","pred":"nummod","subj":"T9743","obj":"T9744"},{"id":"R8543","pred":"nsubj","subj":"T9744","obj":"T9749"},{"id":"R8544","pred":"cc","subj":"T9745","obj":"T9744"},{"id":"R8545","pred":"nummod","subj":"T9746","obj":"T9748"},{"id":"R8546","pred":"compound","subj":"T9747","obj":"T9748"},{"id":"R8547","pred":"conj","subj":"T9748","obj":"T9744"},{"id":"R8548","pred":"ROOT","subj":"T9749","obj":"T9749"},{"id":"R8549","pred":"det","subj":"T9750","obj":"T9752"},{"id":"R8550","pred":"amod","subj":"T9751","obj":"T9752"},{"id":"R8551","pred":"dobj","subj":"T9752","obj":"T9749"},{"id":"R8552","pred":"prep","subj":"T9753","obj":"T9752"},{"id":"R8553","pred":"pobj","subj":"T9754","obj":"T9753"},{"id":"R8554","pred":"prep","subj":"T9755","obj":"T9752"},{"id":"R8555","pred":"det","subj":"T9756","obj":"T9757"},{"id":"R8556","pred":"pobj","subj":"T9757","obj":"T9755"},{"id":"R8557","pred":"cc","subj":"T9758","obj":"T9757"},{"id":"R8558","pred":"conj","subj":"T9759","obj":"T9757"},{"id":"R8559","pred":"punct","subj":"T9760","obj":"T9761"},{"id":"R8560","pred":"appos","subj":"T9761","obj":"T9759"},{"id":"R8561","pred":"nummod","subj":"T9762","obj":"T9761"},{"id":"R8562","pred":"punct","subj":"T9763","obj":"T9759"},{"id":"R8563","pred":"punct","subj":"T9764","obj":"T9749"},{"id":"R8564","pred":"amod","subj":"T9765","obj":"T9767"},{"id":"R8565","pred":"compound","subj":"T9766","obj":"T9767"},{"id":"R8566","pred":"nsubjpass","subj":"T9767","obj":"T9770"},{"id":"R8567","pred":"auxpass","subj":"T9768","obj":"T9770"},{"id":"R8568","pred":"neg","subj":"T9769","obj":"T9770"},{"id":"R8569","pred":"ROOT","subj":"T9770","obj":"T9770"},{"id":"R8570","pred":"agent","subj":"T9771","obj":"T9770"},{"id":"R8571","pred":"compound","subj":"T9772","obj":"T9773"},{"id":"R8572","pred":"pobj","subj":"T9773","obj":"T9771"},{"id":"R8573","pred":"punct","subj":"T9774","obj":"T9770"},{"id":"R14866","pred":"amod","subj":"T17369","obj":"T17370"},{"id":"R14867","pred":"nsubj","subj":"T17370","obj":"T17371"},{"id":"R14868","pred":"ROOT","subj":"T17371","obj":"T17371"},{"id":"R14869","pred":"poss","subj":"T17372","obj":"T17376"},{"id":"R14870","pred":"cc","subj":"T17373","obj":"T17372"},{"id":"R14871","pred":"conj","subj":"T17374","obj":"T17372"},{"id":"R14872","pred":"compound","subj":"T17375","obj":"T17376"},{"id":"R14873","pred":"dobj","subj":"T17376","obj":"T17371"},{"id":"R14874","pred":"prep","subj":"T17377","obj":"T17371"},{"id":"R14875","pred":"pobj","subj":"T17378","obj":"T17377"},{"id":"R14876","pred":"punct","subj":"T17379","obj":"T17371"},{"id":"R14877","pred":"ROOT","subj":"T17380","obj":"T17380"},{"id":"R14878","pred":"dobj","subj":"T17381","obj":"T17380"},{"id":"R14879","pred":"prep","subj":"T17382","obj":"T17381"},{"id":"R14880","pred":"amod","subj":"T17383","obj":"T17384"},{"id":"R14881","pred":"pobj","subj":"T17384","obj":"T17382"},{"id":"R14882","pred":"acl","subj":"T17385","obj":"T17384"},{"id":"R14883","pred":"prep","subj":"T17386","obj":"T17385"},{"id":"R14884","pred":"pobj","subj":"T17387","obj":"T17386"},{"id":"R14885","pred":"prep","subj":"T17388","obj":"T17387"},{"id":"R14886","pred":"pobj","subj":"T17389","obj":"T17388"},{"id":"R14887","pred":"cc","subj":"T17390","obj":"T17389"},{"id":"R14888","pred":"conj","subj":"T17391","obj":"T17389"},{"id":"R14889","pred":"prep","subj":"T17392","obj":"T17385"},{"id":"R14890","pred":"pobj","subj":"T17393","obj":"T17392"},{"id":"R14891","pred":"prep","subj":"T17394","obj":"T17393"},{"id":"R14892","pred":"pobj","subj":"T17395","obj":"T17394"},{"id":"R14893","pred":"prep","subj":"T17396","obj":"T17380"},{"id":"R14894","pred":"nummod","subj":"T17397","obj":"T17398"},{"id":"R14895","pred":"pobj","subj":"T17398","obj":"T17396"},{"id":"R14896","pred":"prep","subj":"T17399","obj":"T17398"},{"id":"R14897","pred":"amod","subj":"T17400","obj":"T17401"},{"id":"R14898","pred":"pobj","subj":"T17401","obj":"T17399"},{"id":"R14899","pred":"punct","subj":"T17402","obj":"T17380"},{"id":"R14900","pred":"amod","subj":"T17403","obj":"T17404"},{"id":"R14901","pred":"nsubjpass","subj":"T17404","obj":"T17406"},{"id":"R14902","pred":"auxpass","subj":"T17405","obj":"T17406"},{"id":"R14903","pred":"ROOT","subj":"T17406","obj":"T17406"},{"id":"R14904","pred":"prep","subj":"T17407","obj":"T17406"},{"id":"R14905","pred":"compound","subj":"T17408","obj":"T17409"},{"id":"R14906","pred":"pobj","subj":"T17409","obj":"T17407"},{"id":"R14907","pred":"punct","subj":"T17410","obj":"T17406"}],"text":"Degraded CGN Induce an Increase in ICAM-1 and TNF-α mRNA Expression\nThe increase in surface ICAM-1 expression and TNF-α production by monocytes correlated with an upregulation of mRNA for these molecules. Both 10 kDa and 40 kDa dCGN induced a robust increase in mRNA for both ICAM-1 and TNF-α (Fig. 6). β-actin mRNA levels were not affected by dCGN treatment.\n10.1371/journal.pone.0008666.g006 Figure 6 Degraded CGN stimulated ICAM-1 and TNF-α gene expression in monocytes.\nRepresentative samples of RT-PCR analysis showing over expression of ICAM-1 and TNF-α after stimulation of monocytes with 1 g/l of degraded CGN. β-actin expression was used as normalization gene.\n\nD"}

    sentences

    {"project":"sentences","denotations":[{"id":"T9632","span":{"begin":0,"end":67},"obj":"Sentence"},{"id":"T9633","span":{"begin":68,"end":204},"obj":"Sentence"},{"id":"T9634","span":{"begin":205,"end":359},"obj":"Sentence"},{"id":"T17321","span":{"begin":404,"end":474},"obj":"Sentence"},{"id":"T17322","span":{"begin":475,"end":670},"obj":"Sentence"},{"id":"T221","span":{"begin":0,"end":67},"obj":"Sentence"},{"id":"T222","span":{"begin":68,"end":204},"obj":"Sentence"},{"id":"T223","span":{"begin":205,"end":359},"obj":"Sentence"},{"id":"T224","span":{"begin":360,"end":474},"obj":"Sentence"},{"id":"T225","span":{"begin":475,"end":670},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Degraded CGN Induce an Increase in ICAM-1 and TNF-α mRNA Expression\nThe increase in surface ICAM-1 expression and TNF-α production by monocytes correlated with an upregulation of mRNA for these molecules. Both 10 kDa and 40 kDa dCGN induced a robust increase in mRNA for both ICAM-1 and TNF-α (Fig. 6). β-actin mRNA levels were not affected by dCGN treatment.\n10.1371/journal.pone.0008666.g006 Figure 6 Degraded CGN stimulated ICAM-1 and TNF-α gene expression in monocytes.\nRepresentative samples of RT-PCR analysis showing over expression of ICAM-1 and TNF-α after stimulation of monocytes with 1 g/l of degraded CGN. β-actin expression was used as normalization gene.\n\nD"}

    events-check-again

    {"project":"events-check-again","denotations":[{"id":"T9829","span":{"begin":13,"end":19},"obj":"Positive_regulation"},{"id":"T9830","span":{"begin":13,"end":19},"obj":"Positive_regulation"},{"id":"T9831","span":{"begin":23,"end":31},"obj":"Positive_regulation"},{"id":"T9832","span":{"begin":23,"end":31},"obj":"Positive_regulation"},{"id":"T9833","span":{"begin":35,"end":41},"obj":"Protein"},{"id":"T9834","span":{"begin":46,"end":51},"obj":"Protein"},{"id":"T9835","span":{"begin":52,"end":67},"obj":"Transcription"},{"id":"T9836","span":{"begin":52,"end":67},"obj":"Transcription"},{"id":"T9837","span":{"begin":72,"end":80},"obj":"Positive_regulation"},{"id":"T9838","span":{"begin":72,"end":80},"obj":"Positive_regulation"},{"id":"T9839","span":{"begin":92,"end":98},"obj":"Protein"},{"id":"T9840","span":{"begin":99,"end":109},"obj":"Gene_expression"},{"id":"T9841","span":{"begin":114,"end":119},"obj":"Protein"},{"id":"T9842","span":{"begin":120,"end":130},"obj":"Gene_expression"},{"id":"T9843","span":{"begin":163,"end":175},"obj":"Positive_regulation"},{"id":"T9844","span":{"begin":163,"end":175},"obj":"Positive_regulation"},{"id":"T9845","span":{"begin":233,"end":240},"obj":"Positive_regulation"},{"id":"T9846","span":{"begin":233,"end":240},"obj":"Positive_regulation"},{"id":"T9847","span":{"begin":250,"end":258},"obj":"Positive_regulation"},{"id":"T9848","span":{"begin":250,"end":258},"obj":"Positive_regulation"},{"id":"T9849","span":{"begin":276,"end":282},"obj":"Protein"},{"id":"T9850","span":{"begin":287,"end":292},"obj":"Protein"},{"id":"T9851","span":{"begin":303,"end":310},"obj":"Protein"},{"id":"T9852","span":{"begin":332,"end":340},"obj":"Regulation"},{"id":"T17442","span":{"begin":417,"end":427},"obj":"Positive_regulation"},{"id":"T17443","span":{"begin":417,"end":427},"obj":"Positive_regulation"},{"id":"T17444","span":{"begin":428,"end":434},"obj":"Protein"},{"id":"T17445","span":{"begin":439,"end":444},"obj":"Protein"},{"id":"T17446","span":{"begin":450,"end":460},"obj":"Gene_expression"},{"id":"T17447","span":{"begin":450,"end":460},"obj":"Gene_expression"},{"id":"T17448","span":{"begin":530,"end":540},"obj":"Gene_expression"},{"id":"T17449","span":{"begin":530,"end":540},"obj":"Gene_expression"},{"id":"T17450","span":{"begin":544,"end":550},"obj":"Protein"},{"id":"T17451","span":{"begin":555,"end":560},"obj":"Protein"},{"id":"T17452","span":{"begin":620,"end":627},"obj":"Protein"},{"id":"T17453","span":{"begin":628,"end":638},"obj":"Gene_expression"}],"relations":[{"id":"R8608","pred":"themeOf","subj":"T9831","obj":"T9829"},{"id":"R8609","pred":"themeOf","subj":"T9832","obj":"T9830"},{"id":"R8610","pred":"themeOf","subj":"T9833","obj":"T9835"},{"id":"R8611","pred":"themeOf","subj":"T9834","obj":"T9836"},{"id":"R8612","pred":"themeOf","subj":"T9835","obj":"T9831"},{"id":"R8613","pred":"themeOf","subj":"T9836","obj":"T9832"},{"id":"R8614","pred":"themeOf","subj":"T9839","obj":"T9840"},{"id":"R8615","pred":"themeOf","subj":"T9839","obj":"T9844"},{"id":"R8616","pred":"themeOf","subj":"T9840","obj":"T9838"},{"id":"R8617","pred":"themeOf","subj":"T9841","obj":"T9842"},{"id":"R8618","pred":"themeOf","subj":"T9841","obj":"T9843"},{"id":"R8619","pred":"themeOf","subj":"T9842","obj":"T9837"},{"id":"R8620","pred":"themeOf","subj":"T9847","obj":"T9846"},{"id":"R8621","pred":"themeOf","subj":"T9848","obj":"T9845"},{"id":"R8622","pred":"themeOf","subj":"T9849","obj":"T9848"},{"id":"R8623","pred":"themeOf","subj":"T9850","obj":"T9847"},{"id":"R8624","pred":"themeOf","subj":"T9851","obj":"T9852"},{"id":"R14922","pred":"themeOf","subj":"T17444","obj":"T17447"},{"id":"R14923","pred":"themeOf","subj":"T17445","obj":"T17446"},{"id":"R14924","pred":"themeOf","subj":"T17446","obj":"T17443"},{"id":"R14925","pred":"themeOf","subj":"T17447","obj":"T17442"},{"id":"R14926","pred":"themeOf","subj":"T17450","obj":"T17448"},{"id":"R14927","pred":"themeOf","subj":"T17451","obj":"T17449"},{"id":"R14928","pred":"themeOf","subj":"T17452","obj":"T17453"}],"attributes":[{"id":"M29","pred":"Negation","subj":"T9852","obj":"true"}],"text":"Degraded CGN Induce an Increase in ICAM-1 and TNF-α mRNA Expression\nThe increase in surface ICAM-1 expression and TNF-α production by monocytes correlated with an upregulation of mRNA for these molecules. Both 10 kDa and 40 kDa dCGN induced a robust increase in mRNA for both ICAM-1 and TNF-α (Fig. 6). β-actin mRNA levels were not affected by dCGN treatment.\n10.1371/journal.pone.0008666.g006 Figure 6 Degraded CGN stimulated ICAM-1 and TNF-α gene expression in monocytes.\nRepresentative samples of RT-PCR analysis showing over expression of ICAM-1 and TNF-α after stimulation of monocytes with 1 g/l of degraded CGN. β-actin expression was used as normalization gene.\n\nD"}

    bionlp-st-ge-2016-reference-tees

    {"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T9853","span":{"begin":35,"end":41},"obj":"Protein"},{"id":"T9854","span":{"begin":46,"end":56},"obj":"Protein"},{"id":"T9855","span":{"begin":57,"end":67},"obj":"Gene_expression"},{"id":"T9856","span":{"begin":57,"end":67},"obj":"Gene_expression"},{"id":"T9857","span":{"begin":23,"end":31},"obj":"Positive_regulation"},{"id":"T9858","span":{"begin":23,"end":31},"obj":"Positive_regulation"},{"id":"T9859","span":{"begin":84,"end":98},"obj":"Protein"},{"id":"T9860","span":{"begin":114,"end":119},"obj":"Protein"},{"id":"T9861","span":{"begin":99,"end":109},"obj":"Gene_expression"},{"id":"T9862","span":{"begin":120,"end":130},"obj":"Gene_expression"},{"id":"T9863","span":{"begin":72,"end":80},"obj":"Positive_regulation"},{"id":"T9864","span":{"begin":72,"end":80},"obj":"Positive_regulation"},{"id":"T9865","span":{"begin":276,"end":282},"obj":"Protein"},{"id":"T9866","span":{"begin":287,"end":292},"obj":"Protein"},{"id":"T9867","span":{"begin":294,"end":297},"obj":"Protein"},{"id":"T9868","span":{"begin":303,"end":315},"obj":"Protein"},{"id":"T9869","span":{"begin":250,"end":258},"obj":"Positive_regulation"},{"id":"T9870","span":{"begin":250,"end":258},"obj":"Positive_regulation"},{"id":"T9871","span":{"begin":332,"end":340},"obj":"Regulation"},{"id":"T17454","span":{"begin":413,"end":416},"obj":"Protein"},{"id":"T17455","span":{"begin":428,"end":434},"obj":"Protein"},{"id":"T17456","span":{"begin":439,"end":444},"obj":"Protein"},{"id":"T17457","span":{"begin":404,"end":412},"obj":"Protein_catabolism"},{"id":"T17458","span":{"begin":450,"end":460},"obj":"Gene_expression"},{"id":"T17459","span":{"begin":450,"end":460},"obj":"Gene_expression"},{"id":"T17460","span":{"begin":417,"end":427},"obj":"Positive_regulation"},{"id":"T17461","span":{"begin":417,"end":427},"obj":"Positive_regulation"},{"id":"T17462","span":{"begin":544,"end":550},"obj":"Protein"},{"id":"T17463","span":{"begin":555,"end":560},"obj":"Protein"},{"id":"T17464","span":{"begin":615,"end":618},"obj":"Protein"},{"id":"T17465","span":{"begin":620,"end":627},"obj":"Protein"},{"id":"T17466","span":{"begin":530,"end":540},"obj":"Gene_expression"},{"id":"T17467","span":{"begin":530,"end":540},"obj":"Gene_expression"},{"id":"T17468","span":{"begin":628,"end":638},"obj":"Gene_expression"},{"id":"T17469","span":{"begin":628,"end":638},"obj":"Gene_expression"}],"relations":[{"id":"R8625","pred":"themeOf","subj":"T9853","obj":"T9855"},{"id":"R8626","pred":"themeOf","subj":"T9854","obj":"T9856"},{"id":"R8627","pred":"themeOf","subj":"T9855","obj":"T9857"},{"id":"R8628","pred":"themeOf","subj":"T9856","obj":"T9858"},{"id":"R8629","pred":"themeOf","subj":"T9859","obj":"T9861"},{"id":"R8630","pred":"themeOf","subj":"T9860","obj":"T9862"},{"id":"R8631","pred":"themeOf","subj":"T9861","obj":"T9863"},{"id":"R8632","pred":"themeOf","subj":"T9862","obj":"T9864"},{"id":"R8633","pred":"themeOf","subj":"T9865","obj":"T9869"},{"id":"R8634","pred":"themeOf","subj":"T9866","obj":"T9870"},{"id":"R8635","pred":"themeOf","subj":"T9868","obj":"T9871"},{"id":"R14929","pred":"themeOf","subj":"T17454","obj":"T17457"},{"id":"R14930","pred":"themeOf","subj":"T17455","obj":"T17458"},{"id":"R14931","pred":"themeOf","subj":"T17456","obj":"T17459"},{"id":"R14932","pred":"causeOf","subj":"T17457","obj":"T17460"},{"id":"R14933","pred":"causeOf","subj":"T17457","obj":"T17461"},{"id":"R14934","pred":"themeOf","subj":"T17458","obj":"T17460"},{"id":"R14935","pred":"themeOf","subj":"T17459","obj":"T17461"},{"id":"R14936","pred":"themeOf","subj":"T17462","obj":"T17466"},{"id":"R14937","pred":"themeOf","subj":"T17463","obj":"T17467"},{"id":"R14938","pred":"themeOf","subj":"T17464","obj":"T17468"},{"id":"R14939","pred":"themeOf","subj":"T17465","obj":"T17469"}],"text":"Degraded CGN Induce an Increase in ICAM-1 and TNF-α mRNA Expression\nThe increase in surface ICAM-1 expression and TNF-α production by monocytes correlated with an upregulation of mRNA for these molecules. Both 10 kDa and 40 kDa dCGN induced a robust increase in mRNA for both ICAM-1 and TNF-α (Fig. 6). β-actin mRNA levels were not affected by dCGN treatment.\n10.1371/journal.pone.0008666.g006 Figure 6 Degraded CGN stimulated ICAM-1 and TNF-α gene expression in monocytes.\nRepresentative samples of RT-PCR analysis showing over expression of ICAM-1 and TNF-α after stimulation of monocytes with 1 g/l of degraded CGN. β-actin expression was used as normalization gene.\n\nD"}

    bionlp-st-ge-2016-reference

    {"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T9619","span":{"begin":99,"end":109},"obj":"Gene_expression"},{"id":"T9620","span":{"begin":114,"end":119},"obj":"Protein"},{"id":"T9621","span":{"begin":120,"end":130},"obj":"Gene_expression"},{"id":"T9622","span":{"begin":163,"end":175},"obj":"Positive_regulation"},{"id":"T9624","span":{"begin":233,"end":240},"obj":"Positive_regulation"},{"id":"T9625","span":{"begin":233,"end":240},"obj":"Positive_regulation"},{"id":"T9626","span":{"begin":250,"end":258},"obj":"Positive_regulation"},{"id":"T9627","span":{"begin":250,"end":258},"obj":"Positive_regulation"},{"id":"T9628","span":{"begin":276,"end":282},"obj":"Protein"},{"id":"T9629","span":{"begin":287,"end":292},"obj":"Protein"},{"id":"T9630","span":{"begin":303,"end":310},"obj":"Protein"},{"id":"T9631","span":{"begin":332,"end":340},"obj":"Regulation"},{"id":"T17309","span":{"begin":417,"end":427},"obj":"Positive_regulation"},{"id":"T17310","span":{"begin":417,"end":427},"obj":"Positive_regulation"},{"id":"T17311","span":{"begin":428,"end":434},"obj":"Protein"},{"id":"T17312","span":{"begin":439,"end":444},"obj":"Protein"},{"id":"T17313","span":{"begin":450,"end":460},"obj":"Gene_expression"},{"id":"T17314","span":{"begin":450,"end":460},"obj":"Gene_expression"},{"id":"T17315","span":{"begin":530,"end":540},"obj":"Gene_expression"},{"id":"T17316","span":{"begin":530,"end":540},"obj":"Gene_expression"},{"id":"T17317","span":{"begin":544,"end":550},"obj":"Protein"},{"id":"T17318","span":{"begin":555,"end":560},"obj":"Protein"},{"id":"T17319","span":{"begin":620,"end":627},"obj":"Protein"},{"id":"T17320","span":{"begin":628,"end":638},"obj":"Gene_expression"},{"id":"T9608","span":{"begin":13,"end":19},"obj":"Positive_regulation"},{"id":"T9609","span":{"begin":13,"end":19},"obj":"Positive_regulation"},{"id":"T9610","span":{"begin":23,"end":31},"obj":"Positive_regulation"},{"id":"T9611","span":{"begin":23,"end":31},"obj":"Positive_regulation"},{"id":"T9612","span":{"begin":35,"end":41},"obj":"Protein"},{"id":"T9613","span":{"begin":46,"end":51},"obj":"Protein"},{"id":"T9614","span":{"begin":52,"end":67},"obj":"Transcription"},{"id":"T9615","span":{"begin":52,"end":67},"obj":"Transcription"},{"id":"T9616","span":{"begin":72,"end":80},"obj":"Positive_regulation"},{"id":"T9617","span":{"begin":72,"end":80},"obj":"Positive_regulation"},{"id":"T9618","span":{"begin":92,"end":98},"obj":"Protein"},{"id":"T9623","span":{"begin":163,"end":175},"obj":"Positive_regulation"}],"relations":[{"id":"R8429","pred":"themeOf","subj":"T9610","obj":"T9608"},{"id":"R8430","pred":"themeOf","subj":"T9611","obj":"T9609"},{"id":"R8431","pred":"themeOf","subj":"T9612","obj":"T9614"},{"id":"R8432","pred":"themeOf","subj":"T9613","obj":"T9615"},{"id":"R8433","pred":"themeOf","subj":"T9614","obj":"T9610"},{"id":"R8434","pred":"themeOf","subj":"T9615","obj":"T9611"},{"id":"R8435","pred":"themeOf","subj":"T9618","obj":"T9619"},{"id":"R8436","pred":"themeOf","subj":"T9618","obj":"T9623"},{"id":"R8437","pred":"themeOf","subj":"T9619","obj":"T9617"},{"id":"R8438","pred":"themeOf","subj":"T9620","obj":"T9621"},{"id":"R8439","pred":"themeOf","subj":"T9620","obj":"T9622"},{"id":"R8440","pred":"themeOf","subj":"T9621","obj":"T9616"},{"id":"R8441","pred":"themeOf","subj":"T9626","obj":"T9625"},{"id":"R8442","pred":"themeOf","subj":"T9627","obj":"T9624"},{"id":"R8443","pred":"themeOf","subj":"T9628","obj":"T9627"},{"id":"R8444","pred":"themeOf","subj":"T9629","obj":"T9626"},{"id":"R8445","pred":"themeOf","subj":"T9630","obj":"T9631"},{"id":"R14825","pred":"themeOf","subj":"T17317","obj":"T17315"},{"id":"R14826","pred":"themeOf","subj":"T17318","obj":"T17316"},{"id":"R14827","pred":"themeOf","subj":"T17319","obj":"T17320"},{"id":"R14821","pred":"themeOf","subj":"T17311","obj":"T17314"},{"id":"R14822","pred":"themeOf","subj":"T17312","obj":"T17313"},{"id":"R14823","pred":"themeOf","subj":"T17313","obj":"T17310"},{"id":"R14824","pred":"themeOf","subj":"T17314","obj":"T17309"}],"attributes":[{"id":"M26","pred":"Negation","subj":"T9631","obj":"true"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Degraded CGN Induce an Increase in ICAM-1 and TNF-α mRNA Expression\nThe increase in surface ICAM-1 expression and TNF-α production by monocytes correlated with an upregulation of mRNA for these molecules. Both 10 kDa and 40 kDa dCGN induced a robust increase in mRNA for both ICAM-1 and TNF-α (Fig. 6). β-actin mRNA levels were not affected by dCGN treatment.\n10.1371/journal.pone.0008666.g006 Figure 6 Degraded CGN stimulated ICAM-1 and TNF-α gene expression in monocytes.\nRepresentative samples of RT-PCR analysis showing over expression of ICAM-1 and TNF-α after stimulation of monocytes with 1 g/l of degraded CGN. β-actin expression was used as normalization gene.\n\nD"}

    bionlp-st-ge-2016-uniprot

    {"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T9700","span":{"begin":35,"end":41},"obj":"P05362"},{"id":"T9701","span":{"begin":46,"end":49},"obj":"P01375"},{"id":"T9702","span":{"begin":46,"end":51},"obj":"P01375"},{"id":"T9703","span":{"begin":92,"end":98},"obj":"P05362"},{"id":"T9704","span":{"begin":114,"end":117},"obj":"P01375"},{"id":"T9705","span":{"begin":114,"end":119},"obj":"P01375"},{"id":"T9706","span":{"begin":276,"end":282},"obj":"P05362"},{"id":"T9707","span":{"begin":287,"end":290},"obj":"P01375"},{"id":"T9708","span":{"begin":287,"end":292},"obj":"P01375"},{"id":"T9709","span":{"begin":303,"end":310},"obj":"P60709"},{"id":"T17362","span":{"begin":428,"end":434},"obj":"P05362"},{"id":"T17363","span":{"begin":439,"end":442},"obj":"P01375"},{"id":"T17364","span":{"begin":439,"end":444},"obj":"P01375"},{"id":"T17365","span":{"begin":544,"end":550},"obj":"P05362"},{"id":"T17366","span":{"begin":555,"end":558},"obj":"P01375"},{"id":"T17367","span":{"begin":555,"end":560},"obj":"P01375"},{"id":"T17368","span":{"begin":620,"end":627},"obj":"P60709"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Degraded CGN Induce an Increase in ICAM-1 and TNF-α mRNA Expression\nThe increase in surface ICAM-1 expression and TNF-α production by monocytes correlated with an upregulation of mRNA for these molecules. Both 10 kDa and 40 kDa dCGN induced a robust increase in mRNA for both ICAM-1 and TNF-α (Fig. 6). β-actin mRNA levels were not affected by dCGN treatment.\n10.1371/journal.pone.0008666.g006 Figure 6 Degraded CGN stimulated ICAM-1 and TNF-α gene expression in monocytes.\nRepresentative samples of RT-PCR analysis showing over expression of ICAM-1 and TNF-α after stimulation of monocytes with 1 g/l of degraded CGN. β-actin expression was used as normalization gene.\n\nD"}

    test2

    {"project":"test2","denotations":[{"id":"T17300","span":{"begin":417,"end":427},"obj":"Positive_regulation"},{"id":"T17301","span":{"begin":428,"end":434},"obj":"Protein"},{"id":"T17302","span":{"begin":439,"end":444},"obj":"Protein"},{"id":"T17303","span":{"begin":450,"end":460},"obj":"Gene_expression"},{"id":"T17304","span":{"begin":530,"end":540},"obj":"Gene_expression"},{"id":"T17305","span":{"begin":544,"end":550},"obj":"Protein"},{"id":"T17306","span":{"begin":555,"end":560},"obj":"Protein"},{"id":"T17307","span":{"begin":620,"end":627},"obj":"Protein"},{"id":"T17308","span":{"begin":628,"end":638},"obj":"Gene_expression"}],"relations":[{"id":"R14815","pred":"themeOf","subj":"T17301","obj":"T17303"},{"id":"R14816","pred":"themeOf","subj":"T17302","obj":"T17303"},{"id":"R14817","pred":"themeOf","subj":"T17303","obj":"T17300"},{"id":"R14818","pred":"themeOf","subj":"T17305","obj":"T17304"},{"id":"R14819","pred":"themeOf","subj":"T17306","obj":"T17304"},{"id":"R14820","pred":"themeOf","subj":"T17307","obj":"T17308"}],"text":"Degraded CGN Induce an Increase in ICAM-1 and TNF-α mRNA Expression\nThe increase in surface ICAM-1 expression and TNF-α production by monocytes correlated with an upregulation of mRNA for these molecules. Both 10 kDa and 40 kDa dCGN induced a robust increase in mRNA for both ICAM-1 and TNF-α (Fig. 6). β-actin mRNA levels were not affected by dCGN treatment.\n10.1371/journal.pone.0008666.g006 Figure 6 Degraded CGN stimulated ICAM-1 and TNF-α gene expression in monocytes.\nRepresentative samples of RT-PCR analysis showing over expression of ICAM-1 and TNF-α after stimulation of monocytes with 1 g/l of degraded CGN. β-actin expression was used as normalization gene.\n\nD"}