PMC:2791889 / 5900-8905 JSON TXT

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bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T3507	0-5	P29459	denotes	IL-12
T3508	0-5	P29460	denotes	IL-12
T3509	78-83	P22301	denotes	IL-10
T3510	138-143	P01579	denotes	IFN-γ
T3511	148-153	P22301	denotes	IL-10
T3512	205-208	P01730	denotes	CD4
T3513	268-277	E2RVI8	denotes	ovalbumin
T3514	295-298	E2RVI8	denotes	OVA
T3515	381-386	P01579	denotes	IFN-γ
T3516	460-465	P22301	denotes	IL-10
T3517	616-620	P05112	denotes	IL-4
T3518	625-630	P22301	denotes	IL-10
T3519	681-684	P01730	denotes	CD4
T3520	741-744	P04234	denotes	CD3
T3521	741-744	P07766	denotes	CD3
T3522	741-744	P20963	denotes	CD3
T3523	741-744	P09693	denotes	CD3
T3524	754-758	P10747	denotes	CD28
T3525	789-794	P29460	denotes	IL-12
T3526	789-794	P29459	denotes	IL-12
T3527	807-812	P01579	denotes	IFN-γ
T3528	867-872	P22301	denotes	IL-10
T3529	917-921	P05112	denotes	IL-4
T3530	971-976	P22301	denotes	IL-10
T3531	1027-1032	P22301	denotes	IL-10
T3532	1099-1104	P29459	denotes	IL-12
T3533	1099-1104	P29460	denotes	IL-12
T3534	1124-1127	P01730	denotes	CD4
T3535	1205-1210	P29460	denotes	IL-12
T3536	1205-1210	P29459	denotes	IL-12
T3537	1237-1242	P29460	denotes	IL-12
T3538	1237-1242	P29459	denotes	IL-12
T3539	1294-1299	P01579	denotes	IFN-γ
T3540	1334-1339	P22301	denotes	IL-10
T3541	1368-1373	P29459	denotes	IL-12
T3542	1368-1373	P29460	denotes	IL-12
T3543	1422-1427	P22301	denotes	IL-10
T3544	1540-1545	P29459	denotes	IL-12
T3545	1540-1545	P29460	denotes	IL-12
T3546	1578-1583	P22301	denotes	IL-10
T3547	1630-1635	P22301	denotes	IL-10
T3548	1729-1734	P22301	denotes	IL-10
T3549	1749-1754	P29459	denotes	IL-12
T3550	1749-1754	P29460	denotes	IL-12
T3551	1835-1840	P22301	denotes	IL-10
T3552	1845-1850	P01579	denotes	IFN-γ
T3553	1886-1890	P60568	denotes	IL-2
T3554	1928-1933	P29460	denotes	IL-12
T3555	1928-1933	P29459	denotes	IL-12
T3556	1963-1966	P01730	denotes	CD4
T3557	2050-2055	P22301	denotes	IL-10
T3558	2092-2097	P22301	denotes	IL-10
T3559	2152-2156	P60568	denotes	IL-2
T3560	2164-2167	P01730	denotes	CD4
T3561	2303-2308	P29460	denotes	IL-12
T3562	2303-2308	P29459	denotes	IL-12
T3563	2327-2332	P22301	denotes	IL-10
T3564	2514-2519	P01137	denotes	TGF-β
T3565	2531-2536	P22301	denotes	IL-10
T3566	2540-2543	P01730	denotes	CD4
T3567	2711-2716	P01137	denotes	TGF-β
T3568	2734-2739	P22301	denotes	IL-10
T3569	2812-2817	P22301	denotes	IL-10
T3570	2871-2876	P29459	denotes	IL-12
T3571	2871-2876	P29460	denotes	IL-12
T3572	2950-2954	P60568	denotes	IL-2
T3573	2958-2963	P01137	denotes	TGF-β

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T2869	295-298	Protein	denotes	OVA
T2870	352-356	Positive_regulation	denotes	rise
T2871	352-356	Positive_regulation	denotes	rise
T2872	370-380	Gene_expression	denotes	expressing	true
T2873	370-380	Gene_expression	denotes	expressing
T2874	381-386	Protein	denotes	IFN-γ
T2875	460-465	Protein	denotes	IL-10
T2876	601-610	Gene_expression	denotes	expressed
T2877	601-610	Gene_expression	denotes	expressed
T2878	616-620	Protein	denotes	IL-4
T2879	625-630	Protein	denotes	IL-10
T2880	681-684	Protein	denotes	CD4
T2881	741-744	Protein	denotes	CD3
T2882	754-758	Protein	denotes	CD28
T2883	789-794	Protein	denotes	IL-12
T2884	795-803	Positive_regulation	denotes	resulted
T2885	795-803	Positive_regulation	denotes	resulted
T2886	807-812	Protein	denotes	IFN-γ
T2887	813-822	Gene_expression	denotes	producing
T2888	856-866	Gene_expression	denotes	coproduced
T2889	867-872	Protein	denotes	IL-10
T2890	917-921	Protein	denotes	IL-4
T2891	963-967	Negative_regulation	denotes	lack
T2892	971-976	Protein	denotes	IL-10
T2893	977-985	Gene_expression	denotes	produced
T2894	999-1007	Positive_regulation	denotes	resulted		true
T2895	1013-1023	Negative_regulation	denotes	inhibition
T2896	1027-1032	Protein	denotes	IL-10
T2897	1033-1043	Gene_expression	denotes	production
T2898	1099-1104	Protein	denotes	IL-12
T2899	1124-1127	Protein	denotes	CD4
T2900	1205-1210	Protein	denotes	IL-12
T2901	1237-1242	Protein	denotes	IL-12
T2902	1286-1293	Positive_regulation	denotes	induced
T2903	1286-1293	Positive_regulation	denotes	induced
T2904	1294-1299	Protein	denotes	IFN-γ
T2905	1300-1310	Gene_expression	denotes	expression
T2906	1334-1339	Protein	denotes	IL-10
T2907	1340-1350	Gene_expression	denotes	expression
T2908	1368-1373	Protein	denotes	IL-12
T2909	1403-1409	Positive_regulation	denotes	induce	true	true
T2910	1422-1427	Protein	denotes	IL-10
T2911	1428-1438	Gene_expression	denotes	production
T2912	1540-1545	Protein	denotes	IL-12
T2913	1578-1583	Protein	denotes	IL-10
T2914	1584-1593	Gene_expression	denotes	producing
T2915	1616-1624	Gene_expression	denotes	produced
T2916	1625-1629	Positive_regulation	denotes	more
T2917	1630-1635	Protein	denotes	IL-10
T2918	1719-1728	Gene_expression	denotes	producing
T2919	1729-1734	Protein	denotes	IL-10
T2920	1735-1743	Positive_regulation	denotes	required
T2921	1749-1754	Protein	denotes	IL-12
T2922	1810-1817	Gene_expression	denotes	produce
T2923	1810-1817	Gene_expression	denotes	produce
T2924	1835-1840	Protein	denotes	IL-10
T2925	1845-1850	Protein	denotes	IFN-γ
T2926	1855-1859	Negative_regulation	denotes	lost
T2927	1878-1885	Gene_expression	denotes	produce
T2928	1886-1890	Protein	denotes	IL-2
T2929	1928-1933	Protein	denotes	IL-12
T2930	1963-1966	Protein	denotes	CD4
T2931	2050-2055	Protein	denotes	IL-10
T2932	2056-2066	Gene_expression	denotes	production
T2933	2092-2097	Protein	denotes	IL-10
T2934	2098-2107	Gene_expression	denotes	producing
T2935	2144-2151	Negative_regulation	denotes	limited
T2936	2152-2156	Protein	denotes	IL-2
T2937	2164-2167	Protein	denotes	CD4
T2938	2190-2221	Protein	denotes	recombination-activating gene 1
T2939	2223-2227	Protein	denotes	Rag1
T2940	2229-2238	Negative_regulation	denotes	deficient
T2941	2303-2308	Protein	denotes	IL-12
T2942	2315-2323	Positive_regulation	denotes	resulted
T2943	2327-2332	Protein	denotes	IL-10
T2944	2333-2343	Gene_expression	denotes	expression
T2945	2395-2404	Positive_regulation	denotes	dependent	true
T2946	2514-2519	Protein	denotes	TGF-β
T2947	2524-2530	Positive_regulation	denotes	induce		true
T2948	2531-2536	Protein	denotes	IL-10
T2949	2540-2543	Protein	denotes	CD4
T2950	2693-2707	Negative_regulation	denotes	neutralization
T2951	2711-2716	Protein	denotes	TGF-β
T2952	2724-2733	Positive_regulation	denotes	increased
T2953	2734-2739	Protein	denotes	IL-10
T2954	2740-2750	Gene_expression	denotes	production
T2955	2812-2817	Protein	denotes	IL-10
T2956	2818-2827	Gene_expression	denotes	producing
T2957	2843-2851	Positive_regulation	denotes	depended	true
T2958	2843-2851	Positive_regulation	denotes	depended
T2959	2843-2851	Positive_regulation	denotes	depended	true
T2960	2871-2876	Protein	denotes	IL-12
T2961	2950-2954	Protein	denotes	IL-2
T2962	2958-2963	Protein	denotes	TGF-β
T2860	0-5	Protein	denotes	IL-12
T2861	68-77	Gene_expression	denotes	Producing
T2862	78-83	Protein	denotes	IL-10
T2863	126-137	Gene_expression	denotes	coproducing
T2864	126-137	Gene_expression	denotes	coproducing
T2865	138-143	Protein	denotes	IFN-γ
T2866	148-153	Protein	denotes	IL-10
T2867	205-208	Protein	denotes	CD4
T2868	268-277	Protein	denotes	ovalbumin
R2157	T2897	T2895	themeOf	production,inhibition
R2158	T2901	T2902	causeOf	IL-12,induced
R2159	T2901	T2903	causeOf	IL-12,induced
R2160	T2904	T2905	themeOf	IFN-γ,expression
R2161	T2905	T2902	themeOf	expression,induced
R2162	T2906	T2907	themeOf	IL-10,expression
R2163	T2907	T2903	themeOf	expression,induced
R2164	T2908	T2909	causeOf	IL-12,induce
R2165	T2910	T2911	themeOf	IL-10,production
R2166	T2911	T2909	themeOf	production,induce
R2167	T2913	T2914	themeOf	IL-10,producing
R2168	T2915	T2916	themeOf	produced,more
R2169	T2917	T2915	themeOf	IL-10,produced
R2170	T2918	T2920	themeOf	producing,required
R2171	T2919	T2918	themeOf	IL-10,producing
R2172	T2921	T2920	causeOf	IL-12,required
R2173	T2924	T2922	themeOf	IL-10,produce
R2174	T2925	T2923	themeOf	IFN-γ,produce
R2175	T2927	T2926	themeOf	produce,lost
R2140	T2872	T2870	themeOf	expressing,rise
R2141	T2873	T2871	themeOf	expressing,rise
R2142	T2874	T2873	themeOf	IFN-γ,expressing
R2143	T2875	T2872	themeOf	IL-10,expressing
R2144	T2878	T2877	themeOf	IL-4,expressed
R2145	T2879	T2876	themeOf	IL-10,expressed
R2146	T2883	T2885	causeOf	IL-12,resulted
R2147	T2883	T2884	causeOf	IL-12,resulted
R2148	T2886	T2887	themeOf	IFN-γ,producing
R2149	T2887	T2885	themeOf	producing,resulted
R2150	T2888	T2884	themeOf	coproduced,resulted
R2151	T2889	T2888	themeOf	IL-10,coproduced
R2152	T2891	T2894	themeOf	lack,resulted
R2153	T2892	T2891	themeOf	IL-10,lack
R2154	T2892	T2893	themeOf	IL-10,produced
R2155	T2895	T2894	causeOf	inhibition,resulted
R2156	T2896	T2897	themeOf	IL-10,production
R2136	T2862	T2861	themeOf	IL-10,Producing
R2137	T2865	T2864	themeOf	IFN-γ,coproducing
R2138	T2866	T2863	themeOf	IL-10,coproducing
R2139	T2869	T2868	equivalentTo	OVA,ovalbumin
R2176	T2928	T2927	themeOf	IL-2,produce
R2177	T2931	T2932	themeOf	IL-10,production
R2178	T2933	T2934	themeOf	IL-10,producing
R2179	T2936	T2935	themeOf	IL-2,limited
R2180	T2938	T2940	themeOf	recombination-activating gene 1,deficient
R2181	T2939	T2938	equivalentTo	Rag1,recombination-activating gene 1
R2182	T2941	T2942	causeOf	IL-12,resulted
R2183	T2943	T2944	themeOf	IL-10,expression
R2184	T2944	T2942	themeOf	expression,resulted
R2185	T2944	T2945	themeOf	expression,dependent
R2186	T2946	T2947	causeOf	TGF-β,induce
R2187	T2948	T2947	themeOf	IL-10,induce
R2188	T2950	T2952	causeOf	neutralization,increased
R2189	T2951	T2950	themeOf	TGF-β,neutralization
R2190	T2953	T2954	themeOf	IL-10,production
R2191	T2954	T2952	themeOf	production,increased
R2192	T2955	T2956	themeOf	IL-10,producing
R2193	T2956	T2958	themeOf	producing,depended
R2194	T2956	T2957	themeOf	producing,depended
R2195	T2956	T2959	themeOf	producing,depended
R2196	T2960	T2958	causeOf	IL-12,depended
R2197	T2961	T2957	causeOf	IL-2,depended
R2198	T2962	T2959	causeOf	TGF-β,depended

2_test

Id	Subject	Object	Predicate	Lexical cue
19646904-7595230-46582684	445-449	7595230	denotes	1995
19646904-7595228-46582684	445-449	7595228	denotes	1995
19646904-14557415-46582685	2591-2595	14557415	denotes	2000
19646904-10880840-46582685	2591-2595	10880840	denotes	2000
T10777	445-449	7595230	denotes	1995
T18378	445-449	7595228	denotes	1995
T24066	2591-2595	14557415	denotes	2000
T49812	2591-2595	10880840	denotes	2000

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T2978	0-5	NN	denotes	IL-12
T2979	6-9	CC	denotes	and
T2980	10-14	JJ	denotes	High
T2981	15-20	NN	denotes	Doses
T2982	21-23	IN	denotes	of
T2983	24-31	NN	denotes	Antigen
T2984	32-38	VB	denotes	Induce
T2985	39-42	DT	denotes	the
T2986	43-54	NN	denotes	Development
T2987	55-57	IN	denotes	of
T2988	58-61	NN	denotes	Th1
T2989	62-67	NN	denotes	Cells
T2990	68-77	VB	denotes	Producing
T2991	78-83	NN	denotes	IL-10
T2992	84-86	TO	denotes	To
T2993	87-92	VB	denotes	study
T2994	93-96	DT	denotes	the
T2995	97-112	NN	denotes	differentiation
T2996	113-115	IN	denotes	of
T2997	116-119	NN	denotes	Th1
T2998	120-125	NN	denotes	cells
T2999	126-137	VB	denotes	coproducing
T3000	138-143	NN	denotes	IFN-γ
T3001	144-147	CC	denotes	and
T3002	148-153	NN	denotes	IL-10
T3003	153-154	-COMMA-	denotes	,
T3004	155-157	PRP	denotes	we
T3005	158-166	VB	denotes	cultured
T3006	167-175	VB	denotes	purified
T3007	176-190	JJ	denotes	TCR-transgenic
T3008	191-198	NN	denotes	DO11.10
T3009	199-204	JJ	denotes	naive
T3010	205-209	JJ	denotes	CD4+
T3011	210-217	NN	denotes	T cells
T3012	218-222	IN	denotes	with
T3013	223-231	VB	denotes	purified
T3014	232-235	NN	denotes	DCs
T3015	236-238	IN	denotes	as
T3016	239-243	NN	denotes	APCs
T3017	244-247	CC	denotes	and
T3018	248-258	VB	denotes	increasing
T3019	259-264	NN	denotes	doses
T3020	265-267	IN	denotes	of
T3021	268-277	NN	denotes	ovalbumin
T3022	278-285	NN	denotes	peptide
T3023	286-293	CD	denotes	323-339
T3024	294-295	-LRB-	denotes	(
T3025	295-298	NN	denotes	OVA
T3026	298-299	-RRB-	denotes	)
T3027	301-308	NN	denotes	Culture
T3028	309-313	IN	denotes	with
T3029	314-318	JJ	denotes	high
T3030	319-324	NN	denotes	doses
T3031	325-327	IN	denotes	of
T3032	328-335	NN	denotes	antigen
T3033	336-339	IN	denotes	for
T3034	340-341	CD	denotes	7
T3035	342-346	NN	denotes	days
T3036	347-351	VB	denotes	gave
T3037	352-356	NN	denotes	rise
T3038	357-359	TO	denotes	to
T3039	360-363	NN	denotes	Th1
T3040	364-369	NN	denotes	cells
T3041	370-380	VB	denotes	expressing
T3042	381-386	NN	denotes	IFN-γ
T3043	387-391	IN	denotes	upon
T3044	392-405	NN	denotes	restimulation
T3045	406-407	-LRB-	denotes	(
T3046	407-415	JJ	denotes	Constant
T3047	416-422	NN	denotes	et al.
T3048	422-423	-COMMA-	denotes	,
T3049	424-428	CD	denotes	1995
T3050	428-429	-COLON-	denotes	;
T3051	430-436	NNP	denotes	Hosken
T3052	437-443	FW	denotes	et al.
T3053	443-444	-COMMA-	denotes	,
T3054	445-449	CD	denotes	1995
T3055	449-450	-RRB-	denotes	)
T3056	450-451	-COMMA-	denotes	,
T3057	452-455	CC	denotes	but
T3058	456-459	RB	denotes	not
T3059	460-465	NN	denotes	IL-10
T3060	466-467	-LRB-	denotes	(
T3061	467-477	NN	denotes	Figure S1A
T3062	478-487	JJ	denotes	available
T3063	488-494	NN	denotes	online
T3064	494-495	-RRB-	denotes	)
T3065	497-504	NN	denotes	Culture
T3066	505-509	IN	denotes	with
T3067	510-513	JJ	denotes	low
T3068	514-521	NN	denotes	antigen
T3069	522-527	NN	denotes	doses
T3070	528-533	IN	denotes	under
T3071	534-537	DT	denotes	the
T3072	538-542	JJ	denotes	same
T3073	543-553	NN	denotes	conditions
T3074	554-557	VB	denotes	led
T3075	558-560	TO	denotes	to
T3076	561-564	DT	denotes	the
T3077	565-580	NN	denotes	differentiation
T3078	581-583	IN	denotes	of
T3079	584-587	NN	denotes	Th2
T3080	588-593	NN	denotes	cells
T3081	593-594	-COMMA-	denotes	,
T3082	595-600	WDT	denotes	which
T3083	601-610	VB	denotes	expressed
T3084	611-615	CC	denotes	both
T3085	616-620	NN	denotes	IL-4
T3086	621-624	CC	denotes	and
T3087	625-630	NN	denotes	IL-10
T3088	631-635	IN	denotes	upon
T3089	636-649	NN	denotes	restimulation
T3090	650-651	-LRB-	denotes	(
T3091	651-661	NN	denotes	Figure S1A
T3092	661-662	-RRB-	denotes	)
T3093	664-671	NN	denotes	Culture
T3094	672-674	IN	denotes	of
T3095	675-680	JJ	denotes	naive
T3096	681-685	JJ	denotes	CD4+
T3097	686-693	NN	denotes	T cells
T3098	694-696	IN	denotes	in
T3099	697-699	DT	denotes	an
T3100	700-708	JJ	denotes	APC-free
T3101	709-715	NN	denotes	system
T3102	716-718	IN	denotes	by
T3103	719-730	NN	denotes	stimulation
T3104	731-735	IN	denotes	with
T3105	736-744	JJ	denotes	anti-CD3
T3106	745-748	CC	denotes	and
T3107	749-758	JJ	denotes	anti-CD28
T3108	759-769	NN	denotes	antibodies
T3109	770-772	IN	denotes	in
T3110	773-776	DT	denotes	the
T3111	777-785	NN	denotes	presence
T3112	786-788	IN	denotes	of
T3113	789-794	NN	denotes	IL-12
T3114	795-803	VB	denotes	resulted
T3115	804-806	IN	denotes	in
T3116	807-822	JJ	denotes	IFN-γ-producing
T3117	823-826	NN	denotes	Th1
T3118	827-832	NN	denotes	cells
T3119	832-833	-COMMA-	denotes	,
T3120	834-835	DT	denotes	a
T3121	836-846	NN	denotes	proportion
T3122	847-849	IN	denotes	of
T3123	850-855	WDT	denotes	which
T3124	856-866	VB	denotes	coproduced
T3125	867-872	NN	denotes	IL-10
T3126	872-873	-COMMA-	denotes	,
T3127	874-876	IN	denotes	as
T3128	877-880	VB	denotes	did
T3129	881-884	NN	denotes	Th2
T3130	885-890	NN	denotes	cells
T3131	891-900	VB	denotes	resulting
T3132	901-905	IN	denotes	from
T3133	906-913	NN	denotes	culture
T3134	914-916	IN	denotes	in
T3135	917-921	NN	denotes	IL-4
T3136	922-923	-LRB-	denotes	(
T3137	923-933	NN	denotes	Figure S1B
T3138	933-934	-RRB-	denotes	)
T3139	936-938	TO	denotes	To
T3140	939-950	VB	denotes	investigate
T3141	951-958	IN	denotes	whether
T3142	959-962	DT	denotes	the
T3143	963-967	NN	denotes	lack
T3144	968-970	IN	denotes	of
T3145	971-976	NN	denotes	IL-10
T3146	977-985	VB	denotes	produced
T3147	986-988	IN	denotes	by
T3148	989-992	NN	denotes	Th1
T3149	993-998	NN	denotes	cells
T3150	999-1007	VB	denotes	resulted
T3151	1008-1012	IN	denotes	from
T3152	1013-1023	NN	denotes	inhibition
T3153	1024-1026	IN	denotes	of
T3154	1027-1032	NN	denotes	IL-10
T3155	1033-1043	NN	denotes	production
T3156	1044-1046	IN	denotes	by
T3157	1047-1050	NN	denotes	DCs
T3158	1051-1054	CC	denotes	and
T3159	1055-1059	JJ	denotes	high
T3160	1060-1067	NN	denotes	antigen
T3161	1068-1072	NN	denotes	dose
T3162	1073-1075	CC	denotes	or
T3163	1076-1089	RB	denotes	alternatively
T3164	1090-1098	VB	denotes	required
T3165	1099-1104	NN	denotes	IL-12
T3166	1104-1105	-COMMA-	denotes	,
T3167	1106-1108	PRP	denotes	we
T3168	1109-1117	VB	denotes	cultured
T3169	1118-1123	JJ	denotes	naive
T3170	1124-1128	JJ	denotes	CD4+
T3171	1129-1136	NN	denotes	T cells
T3172	1137-1141	IN	denotes	with
T3173	1142-1152	VB	denotes	increasing
T3174	1153-1158	NN	denotes	doses
T3175	1159-1161	IN	denotes	of
T3176	1162-1169	NN	denotes	antigen
T3177	1170-1179	VB	denotes	presented
T3178	1180-1182	IN	denotes	by
T3179	1183-1185	NN	denotes	DC
T3180	1186-1188	IN	denotes	in
T3181	1189-1192	DT	denotes	the
T3182	1193-1201	NN	denotes	presence
T3183	1202-1204	IN	denotes	of
T3184	1205-1210	NN	denotes	IL-12
T3185	1212-1214	IN	denotes	At
T3186	1215-1218	JJ	denotes	low
T3187	1219-1224	NN	denotes	doses
T3188	1225-1227	IN	denotes	of
T3189	1228-1235	NN	denotes	antigen
T3190	1235-1236	-COMMA-	denotes	,
T3191	1237-1242	NN	denotes	IL-12
T3192	1243-1252	VB	denotes	abrogated
T3193	1253-1256	DT	denotes	the
T3194	1257-1268	NN	denotes	development
T3195	1269-1271	IN	denotes	of
T3196	1272-1275	NN	denotes	Th2
T3197	1276-1281	NN	denotes	cells
T3198	1282-1285	CC	denotes	and
T3199	1286-1293	VB	denotes	induced
T3200	1294-1299	NN	denotes	IFN-γ
T3201	1300-1310	NN	denotes	expression
T3202	1311-1314	CC	denotes	but
T3203	1315-1319	RB	denotes	only
T3204	1320-1323	JJ	denotes	low
T3205	1324-1330	NN	denotes	levels
T3206	1331-1333	IN	denotes	of
T3207	1334-1339	NN	denotes	IL-10
T3208	1340-1350	NN	denotes	expression
T3209	1350-1351	-COMMA-	denotes	,
T3210	1352-1362	VB	denotes	suggesting
T3211	1363-1367	IN	denotes	that
T3212	1368-1373	NN	denotes	IL-12
T3213	1374-1377	FW	denotes	per
T3214	1378-1380	FW	denotes	se
T3215	1381-1384	VB	denotes	was
T3216	1385-1388	RB	denotes	not
T3217	1389-1399	JJ	denotes	sufficient
T3218	1400-1402	TO	denotes	to
T3219	1403-1409	VB	denotes	induce
T3220	1410-1421	JJ	denotes	significant
T3221	1422-1427	NN	denotes	IL-10
T3222	1428-1438	NN	denotes	production
T3223	1439-1441	IN	denotes	in
T3224	1442-1445	NN	denotes	Th1
T3225	1446-1451	NN	denotes	cells
T3226	1452-1453	-LRB-	denotes	(
T3227	1453-1462	NN	denotes	Figure 1A
T3228	1462-1463	-RRB-	denotes	)
T3229	1465-1475	RB	denotes	Strikingly
T3230	1475-1476	-COMMA-	denotes	,
T3231	1477-1479	IN	denotes	as
T3232	1480-1483	DT	denotes	the
T3233	1484-1491	NN	denotes	antigen
T3234	1492-1496	NN	denotes	dose
T3235	1497-1500	VB	denotes	was
T3236	1501-1510	VB	denotes	increased
T3237	1510-1511	-COMMA-	denotes	,
T3238	1512-1515	NN	denotes	Th1
T3239	1516-1527	NN	denotes	populations
T3240	1528-1534	VB	denotes	driven
T3241	1535-1539	IN	denotes	with
T3242	1540-1545	NN	denotes	IL-12
T3243	1546-1549	RB	denotes	now
T3244	1550-1559	VB	denotes	contained
T3245	1560-1566	JJ	denotes	higher
T3246	1567-1574	NN	denotes	numbers
T3247	1575-1577	IN	denotes	of
T3248	1578-1593	JJ	denotes	IL-10-producing
T3249	1594-1599	NN	denotes	cells
T3250	1600-1601	-LRB-	denotes	(
T3251	1601-1610	NN	denotes	Figure 1A
T3252	1610-1611	-RRB-	denotes	)
T3253	1612-1615	CC	denotes	and
T3254	1616-1624	VB	denotes	produced
T3255	1625-1629	JJ	denotes	more
T3256	1630-1635	NN	denotes	IL-10
T3257	1636-1643	NN	denotes	protein
T3258	1644-1648	IN	denotes	upon
T3259	1649-1662	NN	denotes	restimulation
T3260	1663-1664	-LRB-	denotes	(
T3261	1664-1671	NN	denotes	Figures
T3262	1672-1674	NN	denotes	1A
T3263	1675-1678	CC	denotes	and
T3264	1679-1681	NN	denotes	1B
T3265	1681-1682	-RRB-	denotes	)
T3266	1684-1688	RB	denotes	Thus
T3267	1688-1689	-COMMA-	denotes	,
T3268	1690-1693	DT	denotes	the
T3269	1694-1705	NN	denotes	development
T3270	1706-1708	IN	denotes	of
T3271	1709-1712	NN	denotes	Th1
T3272	1713-1718	NN	denotes	cells
T3273	1719-1728	VB	denotes	producing
T3274	1729-1734	NN	denotes	IL-10
T3275	1735-1743	VB	denotes	required
T3276	1744-1748	CC	denotes	both
T3277	1749-1754	NN	denotes	IL-12
T3278	1755-1758	CC	denotes	and
T3279	1759-1763	JJ	denotes	high
T3280	1764-1769	NN	denotes	doses
T3281	1770-1772	IN	denotes	of
T3282	1773-1780	NN	denotes	antigen
T3283	1782-1785	NN	denotes	Th1
T3284	1786-1791	NN	denotes	cells
T3285	1792-1806	VB	denotes	differentiated
T3286	1807-1809	TO	denotes	to
T3287	1810-1817	VB	denotes	produce
T3288	1818-1823	JJ	denotes	large
T3289	1824-1831	NN	denotes	amounts
T3290	1832-1834	IN	denotes	of
T3291	1835-1840	NN	denotes	IL-10
T3292	1841-1844	CC	denotes	and
T3293	1845-1850	NN	denotes	IFN-γ
T3294	1851-1854	CC	denotes	and
T3295	1855-1859	VB	denotes	lost
T3296	1860-1874	NN	denotes	their capacity
T3297	1875-1877	TO	denotes	to
T3298	1878-1885	VB	denotes	produce
T3299	1886-1890	NN	denotes	IL-2
T3300	1891-1892	-LRB-	denotes	(
T3301	1892-1901	NN	denotes	Figure 1B
T3302	1901-1902	-RRB-	denotes	)
T3303	1904-1911	IN	denotes	Because
T3304	1912-1915	DT	denotes	the
T3305	1916-1924	NN	denotes	presence
T3306	1925-1927	IN	denotes	of
T3307	1928-1933	NN	denotes	IL-12
T3308	1934-1941	VB	denotes	reduced
T3309	1942-1945	DT	denotes	the
T3310	1946-1959	NN	denotes	proliferation
T3311	1960-1962	IN	denotes	of
T3312	1963-1967	JJ	denotes	CD4+
T3313	1968-1975	NN	denotes	T cells
T3314	1976-1978	IN	denotes	at
T3315	1979-1983	CC	denotes	both
T3316	1984-1988	JJ	denotes	high
T3317	1989-1996	NN	denotes	and low
T3318	1997-2004	NN	denotes	antigen
T3319	2005-2010	NN	denotes	doses
T3320	2011-2012	-LRB-	denotes	(
T3321	2012-2017	JJ	denotes	Table
T3322	2018-2020	NN	denotes	S1
T3323	2020-2021	-RRB-	denotes	)
T3324	2021-2022	-COMMA-	denotes	,
T3325	2023-2026	CC	denotes	and
T3326	2027-2031	RB	denotes	only
T3327	2032-2035	DT	denotes	the
T3328	2036-2042	JJ	denotes	former
T3329	2043-2049	VB	denotes	showed
T3330	2050-2055	NN	denotes	IL-10
T3331	2056-2066	NN	denotes	production
T3332	2066-2067	-COMMA-	denotes	,
T3333	2068-2071	DT	denotes	the
T3334	2072-2083	NN	denotes	development
T3335	2084-2086	IN	denotes	of
T3336	2087-2091	JJ	denotes	high
T3337	2092-2107	JJ	denotes	IL-10-producing
T3338	2108-2116	NN	denotes	cells is
T3339	2117-2121	RB	denotes	most
T3340	2122-2128	RB	denotes	likely
T3341	2129-2132	RB	denotes	not
T3342	2133-2140	JJ	denotes	related
T3343	2141-2143	TO	denotes	to
T3344	2144-2151	JJ	denotes	limited
T3345	2152-2156	NN	denotes	IL-2
T3346	2158-2163	JJ	denotes	Naive
T3347	2164-2168	JJ	denotes	CD4+
T3348	2169-2176	NN	denotes	T cells
T3349	2177-2181	IN	denotes	from
T3350	2182-2214	JJ	denotes	DO11.10/recombination-activating
T3351	2215-2219	NN	denotes	gene
T3352	2220-2221	CD	denotes	1
T3353	2222-2223	-LRB-	denotes	(
T3354	2223-2227	NN	denotes	Rag1
T3355	2227-2228	-RRB-	denotes	)
T3356	2228-2238	JJ	denotes	-deficient
T3357	2239-2246	NN	denotes	animals
T3358	2246-2247	-COMMA-	denotes	,
T3359	2248-2256	VB	denotes	cultured
T3360	2257-2261	IN	denotes	with
T3361	2262-2266	JJ	denotes	high
T3362	2267-2272	NN	denotes	doses
T3363	2273-2275	IN	denotes	of
T3364	2276-2283	NN	denotes	antigen
T3365	2284-2286	IN	denotes	in
T3366	2287-2290	DT	denotes	the
T3367	2291-2299	NN	denotes	presence
T3368	2300-2302	IN	denotes	of
T3369	2303-2308	NN	denotes	IL-12
T3370	2308-2309	-COMMA-	denotes	,
T3371	2310-2314	RB	denotes	also
T3372	2315-2323	VB	denotes	resulted
T3373	2324-2326	IN	denotes	in
T3374	2327-2332	NN	denotes	IL-10
T3375	2333-2343	NN	denotes	expression
T3376	2344-2346	IN	denotes	by
T3377	2347-2350	NN	denotes	Th1
T3378	2351-2356	NN	denotes	cells
T3379	2356-2357	-COMMA-	denotes	,
T3380	2358-2365	VB	denotes	showing
T3381	2366-2370	IN	denotes	that
T3382	2371-2375	DT	denotes	this
T3383	2376-2386	NN	denotes	expression
T3384	2387-2390	VB	denotes	was
T3385	2391-2394	RB	denotes	not
T3386	2395-2404	JJ	denotes	dependent
T3387	2405-2407	IN	denotes	on
T3388	2408-2411	DT	denotes	the
T3389	2412-2420	NN	denotes	presence
T3390	2421-2423	IN	denotes	of
T3391	2424-2432	NN	denotes	effector
T3392	2433-2435	CC	denotes	or
T3393	2436-2442	NN	denotes	memory
T3394	2443-2450	NN	denotes	T cells
T3395	2451-2453	CC	denotes	or
T3396	2454-2458	NN	denotes	Treg
T3397	2459-2464	NN	denotes	cells
T3398	2465-2466	-LRB-	denotes	(
T3399	2466-2475	NN	denotes	Figure S2
T3400	2475-2476	-RRB-	denotes	)
T3401	2478-2486	IN	denotes	Although
T3402	2487-2489	PRP	denotes	it
T3403	2490-2493	VB	denotes	has
T3404	2494-2498	VB	denotes	been
T3405	2499-2508	VB	denotes	suggested
T3406	2509-2513	IN	denotes	that
T3407	2514-2519	NN	denotes	TGF-β
T3408	2520-2523	MD	denotes	can
T3409	2524-2530	VB	denotes	induce
T3410	2531-2536	NN	denotes	IL-10
T3411	2537-2539	IN	denotes	in
T3412	2540-2544	JJ	denotes	CD4+
T3413	2545-2552	NN	denotes	T cells
T3414	2553-2554	-LRB-	denotes	(
T3415	2554-2560	NNP	denotes	Kitani
T3416	2561-2567	NNP	denotes	et al.
T3417	2567-2568	-COMMA-	denotes	,
T3418	2569-2573	CD	denotes	2003
T3419	2573-2574	-COLON-	denotes	;
T3420	2575-2582	NNP	denotes	Schiott
T3421	2583-2589	FW	denotes	et al.
T3422	2589-2590	-COMMA-	denotes	,
T3423	2591-2595	CD	denotes	2000
T3424	2595-2596	-RRB-	denotes	)
T3425	2596-2597	-COMMA-	denotes	,
T3426	2598-2600	PRP	denotes	we
T3427	2601-2606	VB	denotes	found
T3428	2607-2611	IN	denotes	that
T3429	2612-2614	IN	denotes	in
T3430	2615-2625	VB	denotes	developing
T3431	2626-2629	NN	denotes	Th1
T3432	2630-2633	CC	denotes	and
T3433	2634-2637	NN	denotes	Th2
T3434	2638-2643	NN	denotes	cells
T3435	2644-2648	DT	denotes	this
T3436	2649-2652	VB	denotes	was
T3437	2653-2656	RB	denotes	not
T3438	2657-2660	DT	denotes	the
T3439	2661-2665	NN	denotes	case
T3440	2666-2667	-LRB-	denotes	(
T3441	2667-2671	NN	denotes	data
T3442	2672-2675	RB	denotes	not
T3443	2676-2681	VB	denotes	shown
T3444	2681-2682	-RRB-	denotes	)
T3445	2684-2686	IN	denotes	In
T3446	2687-2691	NN	denotes	fact
T3447	2691-2692	-COMMA-	denotes	,
T3448	2693-2707	NN	denotes	neutralization
T3449	2708-2710	IN	denotes	of
T3450	2711-2716	NN	denotes	TGF-β
T3451	2717-2720	VB	denotes	led
T3452	2721-2723	TO	denotes	to
T3453	2724-2733	VB	denotes	increased
T3454	2734-2739	NN	denotes	IL-10
T3455	2740-2750	NN	denotes	production
T3456	2751-2753	IN	denotes	by
T3457	2754-2758	DT	denotes	both
T3458	2759-2765	NN	denotes	T cell
T3459	2766-2773	NN	denotes	subsets
T3460	2774-2775	-LRB-	denotes	(
T3461	2775-2784	NN	denotes	Figure S3
T3462	2784-2785	-RRB-	denotes	)
T3463	2787-2791	RB	denotes	Thus
T3464	2791-2792	-COMMA-	denotes	,
T3465	2793-2796	DT	denotes	the
T3466	2797-2808	NN	denotes	development
T3467	2809-2811	IN	denotes	of
T3468	2812-2827	JJ	denotes	IL-10-producing
T3469	2828-2831	NN	denotes	Th1
T3470	2832-2837	NN	denotes	cells
T3471	2838-2842	RB	denotes	only
T3472	2843-2851	VB	denotes	depended
T3473	2852-2854	IN	denotes	on
T3474	2855-2858	DT	denotes	the
T3475	2859-2867	NN	denotes	presence
T3476	2868-2870	IN	denotes	of
T3477	2871-2876	NN	denotes	IL-12
T3478	2877-2885	RB	denotes	together
T3479	2886-2890	IN	denotes	with
T3480	2891-2895	JJ	denotes	high
T3481	2896-2903	NN	denotes	antigen
T3482	2904-2908	NN	denotes	dose
T3483	2909-2912	CC	denotes	and
T3484	2913-2916	RB	denotes	not
T3485	2917-2919	IN	denotes	on
T3486	2920-2925	JJ	denotes	other
T3487	2926-2933	JJ	denotes	soluble
T3488	2934-2941	NN	denotes	factors
T3489	2942-2946	JJ	denotes	such
T3490	2947-2949	IN	denotes	as
T3491	2950-2954	NN	denotes	IL-2
T3492	2955-2957	CC	denotes	or
T3493	2958-2963	NN	denotes	TGF-β
T3494	2964-2966	CC	denotes	or
T3495	2967-2969	IN	denotes	on
T3496	2970-2973	DT	denotes	the
T3497	2974-2982	NN	denotes	presence
T3498	2983-2985	IN	denotes	of
T3499	2986-2991	JJ	denotes	other
T3500	2992-2998	NN	denotes	T cell
T3501	2999-3004	NN	denotes	types
R2199	T2978	T2979	arg1Of	IL-12,and
R2200	T2979	T2984	arg1Of	and,Induce
R2201	T2981	T2979	arg2Of	Doses,and
R2202	T2981	T2980	arg1Of	Doses,High
R2203	T2981	T2982	arg1Of	Doses,of
R2204	T2983	T2982	arg2Of	Antigen,of
R2205	T2986	T2984	arg2Of	Development,Induce
R2206	T2986	T2985	arg1Of	Development,the
R2207	T2986	T2987	arg1Of	Development,of
R2208	T2989	T2987	arg2Of	Cells,of
R2209	T2989	T2988	arg1Of	Cells,Th1
R2210	T2989	T2990	arg1Of	Cells,Producing
R2211	T2991	T2990	arg2Of	IL-10,Producing
R2212	T2993	T2992	arg1Of	study,To
R2213	T2995	T2993	arg2Of	differentiation,study
R2214	T2995	T2994	arg1Of	differentiation,the
R2215	T2995	T2996	arg1Of	differentiation,of
R2216	T2998	T2996	arg2Of	cells,of
R2217	T2998	T2997	arg1Of	cells,Th1
R2218	T2998	T2999	arg1Of	cells,coproducing
R2219	T3000	T3001	arg1Of	IFN-γ,and
R2220	T3001	T2999	arg2Of	and,coproducing
R2221	T3002	T3001	arg2Of	IL-10,and
R2222	T3004	T2993	arg1Of	we,study
R2223	T3004	T3005	arg1Of	we,cultured
R2224	T3005	T2992	modOf	cultured,To
R2225	T3005	T3003	arg1Of	cultured,","
R2226	T3005	T3012	arg1Of	cultured,with
R2227	T3009	T3007	arg1Of	naive,TCR-transgenic
R2228	T3009	T3008	arg1Of	naive,DO11.10
R2229	T3011	T3005	arg2Of	T cells,cultured
R2230	T3011	T3006	arg2Of	T cells,purified
R2231	T3011	T3009	arg1Of	T cells,naive
R2232	T3011	T3010	arg1Of	T cells,CD4+
R2233	T3014	T3012	arg2Of	DCs,with
R2234	T3014	T3013	arg2Of	DCs,purified
R2235	T3014	T3015	arg1Of	DCs,as
R2236	T3016	T3017	arg1Of	APCs,and
R2237	T3017	T3015	arg2Of	and,as
R2238	T3019	T3017	arg2Of	doses,and
R2239	T3019	T3018	arg1Of	doses,increasing
R2240	T3019	T3020	arg1Of	doses,of
R2241	T3022	T3020	arg2Of	peptide,of
R2242	T3022	T3021	arg1Of	peptide,ovalbumin
R2243	T3022	T3023	arg1Of	peptide,323-339
R2244	T3022	T3024	arg1Of	peptide,(
R2245	T3025	T3024	arg2Of	OVA,(
R2246	T3026	T3024	arg3Of	),(
R2247	T3027	T3028	arg1Of	Culture,with
R2248	T3027	T3033	arg1Of	Culture,for
R2249	T3027	T3036	arg1Of	Culture,gave
R2250	T3030	T3028	arg2Of	doses,with
R2251	T3030	T3029	arg1Of	doses,high
R2252	T3030	T3031	arg1Of	doses,of
R2253	T3032	T3031	arg2Of	antigen,of
R2254	T3035	T3033	arg2Of	days,for
R2255	T3035	T3034	arg1Of	days,7
R2256	T3037	T3036	arg3Of	rise,gave
R2257	T3040	T3039	arg1Of	cells,Th1
R2258	T3040	T3041	arg1Of	cells,expressing
R2259	T3040	T3045	arg1Of	cells,(
R2260	T3040	T3057	arg1Of	cells,but
R2261	T3041	T3043	arg1Of	expressing,upon
R2262	T3042	T3041	arg2Of	IFN-γ,expressing
R2263	T3044	T3043	arg2Of	restimulation,upon
R2264	T3047	T3045	arg2Of	et al.,(
R2265	T3047	T3046	arg1Of	et al.,Constant
R2266	T3047	T3048	arg1Of	et al.,","
R2267	T3047	T3050	arg1Of	et al.,;
R2268	T3049	T3048	arg2Of	1995,","
R2269	T3051	T3050	arg2Of	Hosken,;
R2270	T3051	T3052	arg1Of	Hosken,et al.
R2271	T3051	T3053	arg1Of	Hosken,","
R2272	T3054	T3053	arg2Of	1995,","
R2273	T3055	T3045	arg3Of	),(
R2274	T3057	T3036	arg2Of	but,gave
R2275	T3057	T3038	arg2Of	but,to
R2276	T3057	T3056	arg1Of	but,","
R2277	T3059	T3057	arg2Of	IL-10,but
R2278	T3059	T3058	arg1Of	IL-10,not
R2279	T3059	T3060	arg1Of	IL-10,(
R2280	T3063	T3060	arg2Of	online,(
R2281	T3063	T3061	arg1Of	online,Figure S1A
R2282	T3063	T3062	arg1Of	online,available
R2283	T3064	T3060	arg3Of	),(
R2284	T3065	T3066	arg1Of	Culture,with
R2285	T3065	T3074	arg1Of	Culture,led
R2286	T3069	T3066	arg2Of	doses,with
R2287	T3069	T3067	arg1Of	doses,low
R2288	T3069	T3068	arg1Of	doses,antigen
R2289	T3069	T3070	arg1Of	doses,under
R2290	T3073	T3070	arg2Of	conditions,under
R2291	T3073	T3071	arg1Of	conditions,the
R2292	T3073	T3072	arg1Of	conditions,same
R2293	T3074	T3075	arg1Of	led,to
R2294	T3077	T3075	arg2Of	differentiation,to
R2295	T3077	T3076	arg1Of	differentiation,the
R2296	T3077	T3078	arg1Of	differentiation,of
R2297	T3080	T3078	arg2Of	cells,of
R2298	T3080	T3079	arg1Of	cells,Th2
R2299	T3080	T3081	arg1Of	cells,","
R2300	T3080	T3082	arg1Of	cells,which
R2301	T3080	T3083	arg1Of	cells,expressed
R2302	T3083	T3088	arg1Of	expressed,upon
R2303	T3085	T3086	arg1Of	IL-4,and
R2304	T3086	T3083	arg2Of	and,expressed
R2305	T3086	T3084	arg1Of	and,both
R2306	T3087	T3086	arg2Of	IL-10,and
R2307	T3089	T3088	arg2Of	restimulation,upon
R2308	T3089	T3090	arg1Of	restimulation,(
R2309	T3091	T3090	arg2Of	Figure S1A,(
R2310	T3092	T3090	arg3Of	),(
R2311	T3093	T3094	arg1Of	Culture,of
R2312	T3093	T3098	arg1Of	Culture,in
R2313	T3093	T3114	arg1Of	Culture,resulted
R2314	T3097	T3094	arg2Of	T cells,of
R2315	T3097	T3095	arg1Of	T cells,naive
R2316	T3097	T3096	arg1Of	T cells,CD4+
R2317	T3101	T3098	arg2Of	system,in
R2318	T3101	T3099	arg1Of	system,an
R2319	T3101	T3100	arg1Of	system,APC-free
R2320	T3101	T3102	arg1Of	system,by
R2321	T3103	T3102	arg2Of	stimulation,by
R2322	T3103	T3104	arg1Of	stimulation,with
R2323	T3105	T3106	arg1Of	anti-CD3,and
R2324	T3107	T3106	arg2Of	anti-CD28,and
R2325	T3108	T3104	arg2Of	antibodies,with
R2326	T3108	T3105	arg1Of	antibodies,anti-CD3
R2327	T3108	T3107	arg1Of	antibodies,anti-CD28
R2328	T3108	T3109	arg1Of	antibodies,in
R2329	T3111	T3109	arg2Of	presence,in
R2330	T3111	T3110	arg1Of	presence,the
R2331	T3111	T3112	arg1Of	presence,of
R2332	T3113	T3112	arg2Of	IL-12,of
R2333	T3114	T3115	arg1Of	resulted,in
R2334	T3118	T3115	arg2Of	cells,in
R2335	T3118	T3116	arg1Of	cells,IFN-γ-producing
R2336	T3118	T3117	arg1Of	cells,Th1
R2337	T3118	T3122	arg2Of	cells,of
R2338	T3118	T3123	arg1Of	cells,which
R2339	T3121	T3120	arg1Of	proportion,a
R2340	T3121	T3122	arg1Of	proportion,of
R2341	T3121	T3124	arg1Of	proportion,coproduced
R2342	T3124	T3119	arg1Of	coproduced,","
R2343	T3124	T3126	arg1Of	coproduced,","
R2344	T3124	T3127	arg1Of	coproduced,as
R2345	T3125	T3124	arg2Of	IL-10,coproduced
R2346	T3128	T3127	arg2Of	did,as
R2347	T3130	T3128	arg1Of	cells,did
R2348	T3130	T3129	arg1Of	cells,Th2
R2349	T3130	T3131	arg1Of	cells,resulting
R2350	T3131	T3132	arg1Of	resulting,from
R2351	T3131	T3134	arg1Of	resulting,in
R2352	T3133	T3132	arg2Of	culture,from
R2353	T3135	T3134	arg2Of	IL-4,in
R2354	T3135	T3136	arg1Of	IL-4,(
R2355	T3137	T3136	arg2Of	Figure S1B,(
R2356	T3138	T3136	arg3Of	),(
R2357	T3140	T3139	arg1Of	investigate,To
R2358	T3143	T3142	arg1Of	lack,the
R2359	T3143	T3144	arg1Of	lack,of
R2360	T3143	T3150	arg1Of	lack,resulted
R2361	T3145	T3144	arg2Of	IL-10,of
R2362	T3145	T3146	arg2Of	IL-10,produced
R2363	T3149	T3146	arg1Of	cells,produced
R2364	T3149	T3147	arg2Of	cells,by
R2365	T3149	T3148	arg1Of	cells,Th1
R2366	T3150	T3140	arg2Of	resulted,investigate
R2367	T3150	T3141	arg1Of	resulted,whether
R2368	T3150	T3151	arg1Of	resulted,from
R2369	T3152	T3153	arg1Of	inhibition,of
R2370	T3152	T3158	arg1Of	inhibition,and
R2371	T3155	T3153	arg2Of	production,of
R2372	T3155	T3154	arg1Of	production,IL-10
R2373	T3155	T3156	arg1Of	production,by
R2374	T3157	T3156	arg2Of	DCs,by
R2375	T3158	T3151	arg2Of	and,from
R2376	T3161	T3159	arg1Of	dose,high
R2377	T3161	T3160	arg1Of	dose,antigen
R2378	T3161	T3162	arg1Of	dose,or
R2379	T3162	T3158	arg2Of	or,and
R2380	T3165	T3162	arg2Of	IL-12,or
R2381	T3165	T3163	arg1Of	IL-12,alternatively
R2382	T3165	T3164	arg2Of	IL-12,required
R2383	T3167	T3140	arg1Of	we,investigate
R2384	T3167	T3168	arg1Of	we,cultured
R2385	T3168	T3139	modOf	cultured,To
R2386	T3168	T3166	arg1Of	cultured,","
R2387	T3171	T3168	arg2Of	T cells,cultured
R2388	T3171	T3169	arg1Of	T cells,naive
R2389	T3171	T3170	arg1Of	T cells,CD4+
R2390	T3171	T3172	arg1Of	T cells,with
R2391	T3174	T3172	arg2Of	doses,with
R2392	T3174	T3173	arg1Of	doses,increasing
R2393	T3174	T3175	arg1Of	doses,of
R2394	T3174	T3177	arg2Of	doses,presented
R2395	T3176	T3175	arg2Of	antigen,of
R2396	T3177	T3180	arg1Of	presented,in
R2397	T3179	T3177	arg1Of	DC,presented
R2398	T3179	T3178	arg2Of	DC,by
R2399	T3182	T3180	arg2Of	presence,in
R2400	T3182	T3181	arg1Of	presence,the
R2401	T3182	T3183	arg1Of	presence,of
R2402	T3184	T3183	arg2Of	IL-12,of
R2403	T3187	T3185	arg2Of	doses,At
R2404	T3187	T3186	arg1Of	doses,low
R2405	T3187	T3188	arg1Of	doses,of
R2406	T3189	T3188	arg2Of	antigen,of
R2407	T3191	T3192	arg1Of	IL-12,abrogated
R2408	T3191	T3199	arg1Of	IL-12,induced
R2409	T3192	T3198	arg1Of	abrogated,and
R2410	T3194	T3192	arg2Of	development,abrogated
R2411	T3194	T3193	arg1Of	development,the
R2412	T3194	T3195	arg1Of	development,of
R2413	T3197	T3195	arg2Of	cells,of
R2414	T3197	T3196	arg1Of	cells,Th2
R2415	T3198	T3185	arg1Of	and,At
R2416	T3198	T3190	arg1Of	and,","
R2417	T3199	T3198	arg2Of	induced,and
R2418	T3199	T3209	arg1Of	induced,","
R2419	T3199	T3210	modOf	induced,suggesting
R2420	T3201	T3200	arg1Of	expression,IFN-γ
R2421	T3201	T3202	arg1Of	expression,but
R2422	T3202	T3199	arg2Of	but,induced
R2423	T3202	T3206	arg1Of	but,of
R2424	T3205	T3202	arg2Of	levels,but
R2425	T3205	T3203	arg1Of	levels,only
R2426	T3205	T3204	arg1Of	levels,low
R2427	T3208	T3206	arg2Of	expression,of
R2428	T3208	T3207	arg1Of	expression,IL-10
R2429	T3212	T3214	arg1Of	IL-12,se
R2430	T3212	T3215	arg1Of	IL-12,was
R2431	T3212	T3217	arg1Of	IL-12,sufficient
R2432	T3214	T3213	arg1Of	se,per
R2433	T3215	T3210	arg2Of	was,suggesting
R2434	T3215	T3211	arg1Of	was,that
R2435	T3215	T3216	arg1Of	was,not
R2436	T3215	T3218	modOf	was,to
R2437	T3217	T3215	arg2Of	sufficient,was
R2438	T3219	T3218	arg1Of	induce,to
R2439	T3219	T3223	arg1Of	induce,in
R2440	T3222	T3219	arg2Of	production,induce
R2441	T3222	T3220	arg1Of	production,significant
R2442	T3222	T3221	arg1Of	production,IL-10
R2443	T3225	T3223	arg2Of	cells,in
R2444	T3225	T3224	arg1Of	cells,Th1
R2445	T3225	T3226	arg1Of	cells,(
R2446	T3227	T3226	arg2Of	Figure 1A,(
R2447	T3228	T3226	arg3Of	),(
R2448	T3234	T3232	arg1Of	dose,the
R2449	T3234	T3233	arg1Of	dose,antigen
R2450	T3234	T3235	arg1Of	dose,was
R2451	T3234	T3236	arg2Of	dose,increased
R2452	T3236	T3231	arg2Of	increased,as
R2453	T3236	T3235	arg2Of	increased,was
R2454	T3239	T3238	arg1Of	populations,Th1
R2455	T3239	T3240	arg2Of	populations,driven
R2456	T3239	T3244	arg1Of	populations,contained
R2457	T3239	T3254	arg1Of	populations,produced
R2458	T3240	T3241	arg1Of	driven,with
R2459	T3242	T3241	arg2Of	IL-12,with
R2460	T3244	T3253	arg1Of	contained,and
R2461	T3246	T3244	arg2Of	numbers,contained
R2462	T3246	T3245	arg1Of	numbers,higher
R2463	T3246	T3247	arg1Of	numbers,of
R2464	T3249	T3247	arg2Of	cells,of
R2465	T3249	T3248	arg1Of	cells,IL-10-producing
R2466	T3249	T3250	arg1Of	cells,(
R2467	T3251	T3250	arg2Of	Figure 1A,(
R2468	T3252	T3250	arg3Of	),(
R2469	T3253	T3229	arg1Of	and,Strikingly
R2470	T3253	T3230	arg1Of	and,","
R2471	T3253	T3231	arg1Of	and,as
R2472	T3253	T3237	arg1Of	and,","
R2473	T3253	T3243	arg1Of	and,now
R2474	T3254	T3253	arg2Of	produced,and
R2475	T3254	T3258	arg1Of	produced,upon
R2476	T3257	T3254	arg2Of	protein,produced
R2477	T3257	T3255	arg1Of	protein,more
R2478	T3257	T3256	arg1Of	protein,IL-10
R2479	T3259	T3258	arg2Of	restimulation,upon
R2480	T3259	T3260	arg1Of	restimulation,(
R2481	T3262	T3263	arg1Of	1A,and
R2482	T3263	T3260	arg2Of	and,(
R2483	T3263	T3261	arg1Of	and,Figures
R2484	T3264	T3263	arg2Of	1B,and
R2485	T3265	T3260	arg3Of	),(
R2486	T3269	T3268	arg1Of	development,the
R2487	T3269	T3270	arg1Of	development,of
R2488	T3269	T3275	arg1Of	development,required
R2489	T3272	T3270	arg2Of	cells,of
R2490	T3272	T3271	arg1Of	cells,Th1
R2491	T3272	T3273	arg1Of	cells,producing
R2492	T3274	T3273	arg2Of	IL-10,producing
R2493	T3275	T3266	arg1Of	required,Thus
R2494	T3275	T3267	arg1Of	required,","
R2495	T3277	T3278	arg1Of	IL-12,and
R2496	T3278	T3275	arg2Of	and,required
R2497	T3278	T3276	arg1Of	and,both
R2498	T3280	T3278	arg2Of	doses,and
R2499	T3280	T3279	arg1Of	doses,high
R2500	T3280	T3281	arg1Of	doses,of
R2501	T3282	T3281	arg2Of	antigen,of
R2502	T3284	T3283	arg1Of	cells,Th1
R2503	T3284	T3285	arg2Of	cells,differentiated
R2504	T3285	T3286	modOf	differentiated,to
R2505	T3287	T3294	arg1Of	produce,and
R2506	T3289	T3287	arg2Of	amounts,produce
R2507	T3289	T3288	arg1Of	amounts,large
R2508	T3289	T3290	arg1Of	amounts,of
R2509	T3291	T3292	arg1Of	IL-10,and
R2510	T3292	T3290	arg2Of	and,of
R2511	T3293	T3292	arg2Of	IFN-γ,and
R2512	T3294	T3286	arg1Of	and,to
R2513	T3295	T3294	arg2Of	lost,and
R2514	T3296	T3295	arg2Of	their capacity,lost
R2515	T3296	T3297	modOf	their capacity,to
R2516	T3298	T3297	arg1Of	produce,to
R2517	T3299	T3298	arg2Of	IL-2,produce
R2518	T3299	T3300	arg1Of	IL-2,(
R2519	T3301	T3300	arg2Of	Figure 1B,(
R2520	T3302	T3300	arg3Of	),(
R2521	T3305	T3304	arg1Of	presence,the
R2522	T3305	T3306	arg1Of	presence,of
R2523	T3305	T3308	arg1Of	presence,reduced
R2524	T3307	T3306	arg2Of	IL-12,of
R2525	T3308	T3314	arg1Of	reduced,at
R2526	T3308	T3325	arg1Of	reduced,and
R2527	T3310	T3308	arg2Of	proliferation,reduced
R2528	T3310	T3309	arg1Of	proliferation,the
R2529	T3310	T3311	arg1Of	proliferation,of
R2530	T3313	T3311	arg2Of	T cells,of
R2531	T3313	T3312	arg1Of	T cells,CD4+
R2532	T3319	T3314	arg2Of	doses,at
R2533	T3319	T3315	arg1Of	doses,both
R2534	T3319	T3316	arg1Of	doses,high
R2535	T3319	T3317	arg1Of	doses,and low
R2536	T3319	T3318	arg1Of	doses,antigen
R2537	T3319	T3320	arg1Of	doses,(
R2538	T3322	T3320	arg2Of	S1,(
R2539	T3322	T3321	arg1Of	S1,Table
R2540	T3323	T3320	arg3Of	),(
R2541	T3325	T3303	arg2Of	and,Because
R2542	T3325	T3324	arg1Of	and,","
R2543	T3328	T3326	arg1Of	former,only
R2544	T3328	T3327	arg1Of	former,the
R2545	T3328	T3329	arg1Of	former,showed
R2546	T3329	T3325	arg2Of	showed,and
R2547	T3331	T3329	arg2Of	production,showed
R2548	T3331	T3330	arg1Of	production,IL-10
R2549	T3331	T3332	arg1Of	production,","
R2550	T3334	T3332	arg2Of	development,","
R2551	T3334	T3333	arg1Of	development,the
R2552	T3334	T3335	arg1Of	development,of
R2553	T3338	T3335	arg2Of	cells is,of
R2554	T3338	T3336	arg1Of	cells is,high
R2555	T3338	T3337	arg1Of	cells is,IL-10-producing
R2556	T3338	T3342	arg1Of	cells is,related
R2557	T3340	T3339	arg1Of	likely,most
R2558	T3342	T3340	arg1Of	related,likely
R2559	T3342	T3341	arg1Of	related,not
R2560	T3342	T3343	arg1Of	related,to
R2561	T3345	T3343	arg2Of	IL-2,to
R2562	T3345	T3344	arg1Of	IL-2,limited
R2563	T3348	T3346	arg1Of	T cells,Naive
R2564	T3348	T3347	arg1Of	T cells,CD4+
R2565	T3348	T3349	arg1Of	T cells,from
R2566	T3348	T3358	arg1Of	T cells,","
R2567	T3348	T3359	arg2Of	T cells,cultured
R2568	T3348	T3372	arg1Of	T cells,resulted
R2569	T3354	T3353	arg2Of	Rag1,(
R2570	T3355	T3353	arg3Of	),(
R2571	T3357	T3349	arg2Of	animals,from
R2572	T3357	T3350	arg1Of	animals,DO11.10/recombination-activating
R2573	T3357	T3351	arg1Of	animals,gene
R2574	T3357	T3352	arg1Of	animals,1
R2575	T3357	T3353	arg1Of	animals,(
R2576	T3357	T3356	arg1Of	animals,-deficient
R2577	T3359	T3360	arg1Of	cultured,with
R2578	T3362	T3360	arg2Of	doses,with
R2579	T3362	T3361	arg1Of	doses,high
R2580	T3362	T3363	arg1Of	doses,of
R2581	T3362	T3365	arg1Of	doses,in
R2582	T3364	T3363	arg2Of	antigen,of
R2583	T3367	T3365	arg2Of	presence,in
R2584	T3367	T3366	arg1Of	presence,the
R2585	T3367	T3368	arg1Of	presence,of
R2586	T3369	T3368	arg2Of	IL-12,of
R2587	T3372	T3370	arg1Of	resulted,","
R2588	T3372	T3371	arg1Of	resulted,also
R2589	T3372	T3373	arg1Of	resulted,in
R2590	T3372	T3379	arg1Of	resulted,","
R2591	T3372	T3380	modOf	resulted,showing
R2592	T3375	T3373	arg2Of	expression,in
R2593	T3375	T3374	arg1Of	expression,IL-10
R2594	T3375	T3376	arg1Of	expression,by
R2595	T3378	T3376	arg2Of	cells,by
R2596	T3378	T3377	arg1Of	cells,Th1
R2597	T3383	T3382	arg1Of	expression,this
R2598	T3383	T3384	arg1Of	expression,was
R2599	T3383	T3386	arg1Of	expression,dependent
R2600	T3384	T3380	arg2Of	was,showing
R2601	T3384	T3381	arg1Of	was,that
R2602	T3384	T3385	arg1Of	was,not
R2603	T3386	T3384	arg2Of	dependent,was
R2604	T3386	T3387	arg1Of	dependent,on
R2605	T3389	T3387	arg2Of	presence,on
R2606	T3389	T3388	arg1Of	presence,the
R2607	T3389	T3390	arg1Of	presence,of
R2608	T3391	T3392	arg1Of	effector,or
R2609	T3393	T3392	arg2Of	memory,or
R2610	T3394	T3391	arg1Of	T cells,effector
R2611	T3394	T3393	arg1Of	T cells,memory
R2612	T3394	T3395	arg1Of	T cells,or
R2613	T3395	T3390	arg2Of	or,of
R2614	T3397	T3395	arg2Of	cells,or
R2615	T3397	T3396	arg1Of	cells,Treg
R2616	T3397	T3398	arg1Of	cells,(
R2617	T3399	T3398	arg2Of	Figure S2,(
R2618	T3400	T3398	arg3Of	),(
R2619	T3402	T3403	arg1Of	it,has
R2620	T3402	T3404	arg1Of	it,been
R2621	T3402	T3405	arg2Of	it,suggested
R2622	T3405	T3401	arg2Of	suggested,Although
R2623	T3405	T3403	arg2Of	suggested,has
R2624	T3405	T3404	arg2Of	suggested,been
R2625	T3407	T3408	arg1Of	TGF-β,can
R2626	T3407	T3409	arg1Of	TGF-β,induce
R2627	T3409	T3405	arg3Of	induce,suggested
R2628	T3409	T3406	arg1Of	induce,that
R2629	T3409	T3408	arg2Of	induce,can
R2630	T3410	T3409	arg2Of	IL-10,induce
R2631	T3410	T3411	arg1Of	IL-10,in
R2632	T3413	T3411	arg2Of	T cells,in
R2633	T3413	T3412	arg1Of	T cells,CD4+
R2634	T3413	T3414	arg1Of	T cells,(
R2635	T3416	T3415	arg1Of	et al.,Kitani
R2636	T3416	T3417	arg1Of	et al.,","
R2637	T3416	T3419	arg1Of	et al.,;
R2638	T3418	T3417	arg2Of	2003,","
R2639	T3419	T3414	arg2Of	;,(
R2640	T3420	T3419	arg2Of	Schiott,;
R2641	T3420	T3421	arg1Of	Schiott,et al.
R2642	T3420	T3422	arg1Of	Schiott,","
R2643	T3423	T3422	arg2Of	2000,","
R2644	T3424	T3414	arg3Of	),(
R2645	T3426	T3427	arg1Of	we,found
R2646	T3427	T3401	arg1Of	found,Although
R2647	T3427	T3425	arg1Of	found,","
R2648	T3431	T3432	arg1Of	Th1,and
R2649	T3433	T3432	arg2Of	Th2,and
R2650	T3434	T3429	arg2Of	cells,in
R2651	T3434	T3430	arg1Of	cells,developing
R2652	T3434	T3431	arg1Of	cells,Th1
R2653	T3434	T3433	arg1Of	cells,Th2
R2654	T3435	T3436	arg1Of	this,was
R2655	T3436	T3427	arg2Of	was,found
R2656	T3436	T3428	arg1Of	was,that
R2657	T3436	T3429	arg1Of	was,in
R2658	T3436	T3437	arg1Of	was,not
R2659	T3439	T3436	arg2Of	case,was
R2660	T3439	T3438	arg1Of	case,the
R2661	T3439	T3440	arg1Of	case,(
R2662	T3441	T3440	arg2Of	data,(
R2663	T3441	T3443	arg2Of	data,shown
R2664	T3443	T3442	arg1Of	shown,not
R2665	T3444	T3440	arg3Of	),(
R2666	T3446	T3445	arg2Of	fact,In
R2667	T3448	T3449	arg1Of	neutralization,of
R2668	T3448	T3451	arg1Of	neutralization,led
R2669	T3450	T3449	arg2Of	TGF-β,of
R2670	T3451	T3445	arg1Of	led,In
R2671	T3451	T3447	arg1Of	led,","
R2672	T3451	T3452	arg1Of	led,to
R2673	T3455	T3452	arg2Of	production,to
R2674	T3455	T3453	arg2Of	production,increased
R2675	T3455	T3454	arg1Of	production,IL-10
R2676	T3455	T3456	arg1Of	production,by
R2677	T3459	T3456	arg2Of	subsets,by
R2678	T3459	T3457	arg1Of	subsets,both
R2679	T3459	T3458	arg1Of	subsets,T cell
R2680	T3459	T3460	arg1Of	subsets,(
R2681	T3461	T3460	arg2Of	Figure S3,(
R2682	T3462	T3460	arg3Of	),(
R2683	T3466	T3465	arg1Of	development,the
R2684	T3466	T3467	arg1Of	development,of
R2685	T3466	T3472	arg1Of	development,depended
R2686	T3470	T3467	arg2Of	cells,of
R2687	T3470	T3468	arg1Of	cells,IL-10-producing
R2688	T3470	T3469	arg1Of	cells,Th1
R2689	T3472	T3463	arg1Of	depended,Thus
R2690	T3472	T3464	arg1Of	depended,","
R2691	T3472	T3471	arg1Of	depended,only
R2692	T3472	T3473	arg1Of	depended,on
R2693	T3472	T3485	arg1Of	depended,on
R2694	T3472	T3495	arg1Of	depended,on
R2695	T3473	T3483	arg1Of	on,and
R2696	T3475	T3473	arg2Of	presence,on
R2697	T3475	T3474	arg1Of	presence,the
R2698	T3475	T3476	arg1Of	presence,of
R2699	T3475	T3478	arg1Of	presence,together
R2700	T3477	T3476	arg2Of	IL-12,of
R2701	T3478	T3479	arg1Of	together,with
R2702	T3482	T3479	arg2Of	dose,with
R2703	T3482	T3480	arg1Of	dose,high
R2704	T3482	T3481	arg1Of	dose,antigen
R2705	T3485	T3494	arg1Of	on,or
R2706	T3488	T3485	arg2Of	factors,on
R2707	T3488	T3486	arg1Of	factors,other
R2708	T3488	T3487	arg1Of	factors,soluble
R2709	T3488	T3490	arg1Of	factors,as
R2710	T3490	T3489	arg1Of	as,such
R2711	T3491	T3492	arg1Of	IL-2,or
R2712	T3492	T3490	arg2Of	or,as
R2713	T3493	T3492	arg2Of	TGF-β,or
R2714	T3494	T3483	arg2Of	or,and
R2715	T3494	T3484	arg1Of	or,not
R2716	T3495	T3494	arg2Of	on,or
R2717	T3497	T3495	arg2Of	presence,on
R2718	T3497	T3496	arg1Of	presence,the
R2719	T3497	T3498	arg1Of	presence,of
R2720	T3501	T3498	arg2Of	types,of
R2721	T3501	T3499	arg1Of	types,other
R2722	T3501	T3500	arg1Of	types,T cell

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T3502	2371-2386	Anaphor	denotes	this expression
T3503	2333-2343	Antecedent	denotes	expression
T3504	2920-2941	Anaphor	denotes	other soluble factors
T3505	2950-2954	Antecedent	denotes	IL-2
T3506	2958-2963	Antecedent	denotes	TGF-β
R2723	T3502	T3503	boundBy	this expression,expression
R2724	T3504	T3505	boundBy	other soluble factors,IL-2
R2725	T3504	T3506	boundBy	other soluble factors,TGF-β

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T3574	0-5	NN	denotes	IL-12
T3575	6-9	CC	denotes	and
T3576	10-14	JJ	denotes	High
T3577	15-20	NNS	denotes	Doses
T3578	21-23	IN	denotes	of
T3579	24-31	NNP	denotes	Antigen
T3580	32-38	NNP	denotes	Induce
T3581	39-42	DT	denotes	the
T3582	43-54	NNP	denotes	Development
T3583	55-57	IN	denotes	of
T3584	58-61	NNP	denotes	Th1
T3585	62-67	NNP	denotes	Cells
T3586	68-77	NNP	denotes	Producing
T3587	78-83	NNP	denotes	IL-10
T3588	84-86	TO	denotes	To
T3589	87-92	VB	denotes	study
T3590	93-96	DT	denotes	the
T3591	97-112	NN	denotes	differentiation
T3592	113-115	IN	denotes	of
T3593	116-119	JJ	denotes	Th1
T3594	120-125	NNS	denotes	cells
T3595	126-137	VBG	denotes	coproducing
T3596	138-143	NNP	denotes	IFN-γ
T3597	144-147	CC	denotes	and
T3598	148-153	NNP	denotes	IL-10
T3599	153-154	,	denotes	,
T3600	155-157	PRP	denotes	we
T3601	158-166	VBD	denotes	cultured
T3602	167-175	VBN	denotes	purified
T3603	176-190	JJ	denotes	TCR-transgenic
T3604	191-195	NNP	denotes	DO11
T3605	195-198	CD	denotes	.10
T3606	199-204	JJ	denotes	naive
T3607	205-208	NNP	denotes	CD4
T3608	208-209	CD	denotes	+
T3609	210-211	NNP	denotes	T
T3610	212-217	NNS	denotes	cells
T3611	218-222	IN	denotes	with
T3612	223-231	JJ	denotes	purified
T3613	232-235	NNS	denotes	DCs
T3614	236-238	IN	denotes	as
T3615	239-243	NNS	denotes	APCs
T3616	244-247	CC	denotes	and
T3617	248-258	VBG	denotes	increasing
T3618	259-264	NNS	denotes	doses
T3619	265-267	IN	denotes	of
T3620	268-277	NN	denotes	ovalbumin
T3621	278-285	NN	denotes	peptide
T3622	286-293	CD	denotes	323-339
T3623	294-295	-LRB-	denotes	(
T3624	295-298	NNP	denotes	OVA
T3625	298-299	-RRB-	denotes	)
T3626	299-300	.	denotes	.
T3627	301-308	NNP	denotes	Culture
T3628	309-313	IN	denotes	with
T3629	314-318	JJ	denotes	high
T3630	319-324	NNS	denotes	doses
T3631	325-327	IN	denotes	of
T3632	328-335	NN	denotes	antigen
T3633	336-339	IN	denotes	for
T3634	340-341	CD	denotes	7
T3635	342-346	NNS	denotes	days
T3636	347-351	VBD	denotes	gave
T3637	352-356	NN	denotes	rise
T3638	357-359	TO	denotes	to
T3639	360-363	CD	denotes	Th1
T3640	364-369	NNS	denotes	cells
T3641	370-380	VBG	denotes	expressing
T3642	381-386	JJ	denotes	IFN-γ
T3643	387-391	IN	denotes	upon
T3644	392-405	NN	denotes	restimulation
T3645	406-407	-LRB-	denotes	(
T3646	407-415	JJ	denotes	Constant
T3647	416-418	FW	denotes	et
T3648	419-422	FW	denotes	al.
T3649	422-423	,	denotes	,
T3650	424-428	CD	denotes	1995
T3651	428-429	:	denotes	;
T3652	430-436	NNP	denotes	Hosken
T3653	437-439	FW	denotes	et
T3654	440-443	FW	denotes	al.
T3655	443-444	,	denotes	,
T3656	445-449	CD	denotes	1995
T3657	449-450	-RRB-	denotes	)
T3658	450-451	,	denotes	,
T3659	452-455	CC	denotes	but
T3660	456-459	RB	denotes	not
T3661	460-465	NNP	denotes	IL-10
T3662	466-467	-LRB-	denotes	(
T3663	467-473	NNP	denotes	Figure
T3664	474-477	NNP	denotes	S1A
T3665	478-487	JJ	denotes	available
T3666	488-494	NN	denotes	online
T3667	494-495	-RRB-	denotes	)
T3668	495-496	.	denotes	.
T3669	497-504	NNP	denotes	Culture
T3670	505-509	IN	denotes	with
T3671	510-513	JJ	denotes	low
T3672	514-521	NN	denotes	antigen
T3673	522-527	NNS	denotes	doses
T3674	528-533	IN	denotes	under
T3675	534-537	DT	denotes	the
T3676	538-542	JJ	denotes	same
T3677	543-553	NNS	denotes	conditions
T3678	554-557	VBD	denotes	led
T3679	558-560	TO	denotes	to
T3680	561-564	DT	denotes	the
T3681	565-580	NN	denotes	differentiation
T3682	581-583	IN	denotes	of
T3683	584-587	JJ	denotes	Th2
T3684	588-593	NNS	denotes	cells
T3685	593-594	,	denotes	,
T3686	595-600	WDT	denotes	which
T3687	601-610	VBD	denotes	expressed
T3688	611-615	DT	denotes	both
T3689	616-620	NN	denotes	IL-4
T3690	621-624	CC	denotes	and
T3691	625-630	NN	denotes	IL-10
T3692	631-635	IN	denotes	upon
T3693	636-649	NN	denotes	restimulation
T3694	650-651	-LRB-	denotes	(
T3695	651-657	NN	denotes	Figure
T3696	658-661	CD	denotes	S1A
T3697	661-662	-RRB-	denotes	)
T3698	662-663	.	denotes	.
T3699	664-671	NNP	denotes	Culture
T3700	672-674	IN	denotes	of
T3701	675-680	JJ	denotes	naive
T3702	681-684	NNP	denotes	CD4
T3703	684-685	CD	denotes	+
T3704	686-687	NNP	denotes	T
T3705	688-693	NNS	denotes	cells
T3706	694-696	IN	denotes	in
T3707	697-699	DT	denotes	an
T3708	700-708	JJ	denotes	APC-free
T3709	709-715	NN	denotes	system
T3710	716-718	IN	denotes	by
T3711	719-730	NN	denotes	stimulation
T3712	731-735	IN	denotes	with
T3713	736-744	JJ	denotes	anti-CD3
T3714	745-748	CC	denotes	and
T3715	749-758	JJ	denotes	anti-CD28
T3716	759-769	NNS	denotes	antibodies
T3717	770-772	IN	denotes	in
T3718	773-776	DT	denotes	the
T3719	777-785	NN	denotes	presence
T3720	786-788	IN	denotes	of
T3721	789-794	NN	denotes	IL-12
T3722	795-803	VBD	denotes	resulted
T3723	804-806	IN	denotes	in
T3724	807-822	JJ	denotes	IFN-γ-producing
T3725	823-826	JJ	denotes	Th1
T3726	827-832	NNS	denotes	cells
T3727	832-833	,	denotes	,
T3728	834-835	DT	denotes	a
T3729	836-846	NN	denotes	proportion
T3730	847-849	IN	denotes	of
T3731	850-855	WDT	denotes	which
T3732	856-866	VBD	denotes	coproduced
T3733	867-872	NNP	denotes	IL-10
T3734	872-873	,	denotes	,
T3735	874-876	IN	denotes	as
T3736	877-880	VBD	denotes	did
T3737	881-884	CD	denotes	Th2
T3738	885-890	NNS	denotes	cells
T3739	891-900	VBG	denotes	resulting
T3740	901-905	IN	denotes	from
T3741	906-913	NN	denotes	culture
T3742	914-916	IN	denotes	in
T3743	917-921	NN	denotes	IL-4
T3744	922-923	-LRB-	denotes	(
T3745	923-929	NN	denotes	Figure
T3746	930-933	CD	denotes	S1B
T3747	933-934	-RRB-	denotes	)
T3748	934-935	.	denotes	.
T3749	936-938	TO	denotes	To
T3750	939-950	VB	denotes	investigate
T3751	951-958	IN	denotes	whether
T3752	959-962	DT	denotes	the
T3753	963-967	NN	denotes	lack
T3754	968-970	IN	denotes	of
T3755	971-976	NN	denotes	IL-10
T3756	977-985	VBN	denotes	produced
T3757	986-988	IN	denotes	by
T3758	989-992	JJ	denotes	Th1
T3759	993-998	NNS	denotes	cells
T3760	999-1007	VBD	denotes	resulted
T3761	1008-1012	IN	denotes	from
T3762	1013-1023	NN	denotes	inhibition
T3763	1024-1026	IN	denotes	of
T3764	1027-1032	JJ	denotes	IL-10
T3765	1033-1043	NN	denotes	production
T3766	1044-1046	IN	denotes	by
T3767	1047-1050	NNP	denotes	DCs
T3768	1051-1054	CC	denotes	and
T3769	1055-1059	JJ	denotes	high
T3770	1060-1067	NN	denotes	antigen
T3771	1068-1072	NN	denotes	dose
T3772	1073-1075	CC	denotes	or
T3773	1076-1089	RB	denotes	alternatively
T3774	1090-1098	VBN	denotes	required
T3775	1099-1104	NN	denotes	IL-12
T3776	1104-1105	,	denotes	,
T3777	1106-1108	PRP	denotes	we
T3778	1109-1117	VBD	denotes	cultured
T3779	1118-1123	JJ	denotes	naive
T3780	1124-1127	NNP	denotes	CD4
T3781	1127-1128	CD	denotes	+
T3782	1129-1130	NNP	denotes	T
T3783	1131-1136	NNS	denotes	cells
T3784	1137-1141	IN	denotes	with
T3785	1142-1152	VBG	denotes	increasing
T3786	1153-1158	NNS	denotes	doses
T3787	1159-1161	IN	denotes	of
T3788	1162-1169	NN	denotes	antigen
T3789	1170-1179	VBN	denotes	presented
T3790	1180-1182	IN	denotes	by
T3791	1183-1185	NNP	denotes	DC
T3792	1186-1188	IN	denotes	in
T3793	1189-1192	DT	denotes	the
T3794	1193-1201	NN	denotes	presence
T3795	1202-1204	IN	denotes	of
T3796	1205-1210	NN	denotes	IL-12
T3797	1210-1211	.	denotes	.
T3798	1212-1214	IN	denotes	At
T3799	1215-1218	JJ	denotes	low
T3800	1219-1224	NNS	denotes	doses
T3801	1225-1227	IN	denotes	of
T3802	1228-1235	NN	denotes	antigen
T3803	1235-1236	,	denotes	,
T3804	1237-1242	NN	denotes	IL-12
T3805	1243-1252	VBD	denotes	abrogated
T3806	1253-1256	DT	denotes	the
T3807	1257-1268	NN	denotes	development
T3808	1269-1271	IN	denotes	of
T3809	1272-1275	JJ	denotes	Th2
T3810	1276-1281	NNS	denotes	cells
T3811	1282-1285	CC	denotes	and
T3812	1286-1293	VBD	denotes	induced
T3813	1294-1299	JJ	denotes	IFN-γ
T3814	1300-1310	NN	denotes	expression
T3815	1311-1314	CC	denotes	but
T3816	1315-1319	RB	denotes	only
T3817	1320-1323	JJ	denotes	low
T3818	1324-1330	NNS	denotes	levels
T3819	1331-1333	IN	denotes	of
T3820	1334-1339	NN	denotes	IL-10
T3821	1340-1350	NN	denotes	expression
T3822	1350-1351	,	denotes	,
T3823	1352-1362	VBG	denotes	suggesting
T3824	1363-1367	IN	denotes	that
T3825	1368-1373	NN	denotes	IL-12
T3826	1374-1377	IN	denotes	per
T3827	1378-1380	FW	denotes	se
T3828	1381-1384	VBD	denotes	was
T3829	1385-1388	RB	denotes	not
T3830	1389-1399	JJ	denotes	sufficient
T3831	1400-1402	TO	denotes	to
T3832	1403-1409	VB	denotes	induce
T3833	1410-1421	JJ	denotes	significant
T3834	1422-1427	NN	denotes	IL-10
T3835	1428-1438	NN	denotes	production
T3836	1439-1441	IN	denotes	in
T3837	1442-1445	JJ	denotes	Th1
T3838	1446-1451	NNS	denotes	cells
T3839	1452-1453	-LRB-	denotes	(
T3840	1453-1459	NN	denotes	Figure
T3841	1460-1462	CD	denotes	1A
T3842	1462-1463	-RRB-	denotes	)
T3843	1463-1464	.	denotes	.
T3844	1465-1475	RB	denotes	Strikingly
T3845	1475-1476	,	denotes	,
T3846	1477-1479	IN	denotes	as
T3847	1480-1483	DT	denotes	the
T3848	1484-1491	NN	denotes	antigen
T3849	1492-1496	NN	denotes	dose
T3850	1497-1500	VBD	denotes	was
T3851	1501-1510	VBN	denotes	increased
T3852	1510-1511	,	denotes	,
T3853	1512-1515	JJ	denotes	Th1
T3854	1516-1527	NNS	denotes	populations
T3855	1528-1534	VBN	denotes	driven
T3856	1535-1539	IN	denotes	with
T3857	1540-1545	NNP	denotes	IL-12
T3858	1546-1549	RB	denotes	now
T3859	1550-1559	VBD	denotes	contained
T3860	1560-1566	JJR	denotes	higher
T3861	1567-1574	NNS	denotes	numbers
T3862	1575-1577	IN	denotes	of
T3863	1578-1593	JJ	denotes	IL-10-producing
T3864	1594-1599	NNS	denotes	cells
T3865	1600-1601	-LRB-	denotes	(
T3866	1601-1607	NN	denotes	Figure
T3867	1608-1610	CD	denotes	1A
T3868	1610-1611	-RRB-	denotes	)
T3869	1612-1615	CC	denotes	and
T3870	1616-1624	VBD	denotes	produced
T3871	1625-1629	RBR	denotes	more
T3872	1630-1635	JJ	denotes	IL-10
T3873	1636-1643	NN	denotes	protein
T3874	1644-1648	IN	denotes	upon
T3875	1649-1662	NN	denotes	restimulation
T3876	1663-1664	-LRB-	denotes	(
T3877	1664-1671	NNS	denotes	Figures
T3878	1672-1674	NNP	denotes	1A
T3879	1675-1678	CC	denotes	and
T3880	1679-1681	NNP	denotes	1B
T3881	1681-1682	-RRB-	denotes	)
T3882	1682-1683	.	denotes	.
T3883	1684-1688	RB	denotes	Thus
T3884	1688-1689	,	denotes	,
T3885	1690-1693	DT	denotes	the
T3886	1694-1705	NN	denotes	development
T3887	1706-1708	IN	denotes	of
T3888	1709-1712	JJ	denotes	Th1
T3889	1713-1718	NNS	denotes	cells
T3890	1719-1728	VBG	denotes	producing
T3891	1729-1734	NN	denotes	IL-10
T3892	1735-1743	VBN	denotes	required
T3893	1744-1748	DT	denotes	both
T3894	1749-1754	NN	denotes	IL-12
T3895	1755-1758	CC	denotes	and
T3896	1759-1763	JJ	denotes	high
T3897	1764-1769	NNS	denotes	doses
T3898	1770-1772	IN	denotes	of
T3899	1773-1780	NN	denotes	antigen
T3900	1780-1781	.	denotes	.
T3901	1782-1785	CD	denotes	Th1
T3902	1786-1791	NNS	denotes	cells
T3903	1792-1806	VBN	denotes	differentiated
T3904	1807-1809	TO	denotes	to
T3905	1810-1817	VB	denotes	produce
T3906	1818-1823	JJ	denotes	large
T3907	1824-1831	NNS	denotes	amounts
T3908	1832-1834	IN	denotes	of
T3909	1835-1840	NNP	denotes	IL-10
T3910	1841-1844	CC	denotes	and
T3911	1845-1850	NNP	denotes	IFN-γ
T3912	1851-1854	CC	denotes	and
T3913	1855-1859	VBD	denotes	lost
T3914	1860-1865	PRP$	denotes	their
T3915	1866-1874	NN	denotes	capacity
T3916	1875-1877	TO	denotes	to
T3917	1878-1885	VB	denotes	produce
T3918	1886-1890	NNP	denotes	IL-2
T3919	1891-1892	-LRB-	denotes	(
T3920	1892-1898	NNP	denotes	Figure
T3921	1899-1901	NNP	denotes	1B
T3922	1901-1902	-RRB-	denotes	)
T3923	1902-1903	.	denotes	.
T3924	1904-1911	IN	denotes	Because
T3925	1912-1915	DT	denotes	the
T3926	1916-1924	NN	denotes	presence
T3927	1925-1927	IN	denotes	of
T3928	1928-1933	NN	denotes	IL-12
T3929	1934-1941	VBD	denotes	reduced
T3930	1942-1945	DT	denotes	the
T3931	1946-1959	NN	denotes	proliferation
T3932	1960-1962	IN	denotes	of
T3933	1963-1966	CD	denotes	CD4
T3934	1966-1967	CD	denotes	+
T3935	1968-1969	NNP	denotes	T
T3936	1970-1975	NNS	denotes	cells
T3937	1976-1978	IN	denotes	at
T3938	1979-1983	DT	denotes	both
T3939	1984-1988	JJ	denotes	high
T3940	1989-1992	CC	denotes	and
T3941	1993-1996	JJ	denotes	low
T3942	1997-2004	NN	denotes	antigen
T3943	2005-2010	NNS	denotes	doses
T3944	2011-2012	-LRB-	denotes	(
T3945	2012-2017	NNP	denotes	Table
T3946	2018-2020	NNP	denotes	S1
T3947	2020-2021	-RRB-	denotes	)
T3948	2021-2022	,	denotes	,
T3949	2023-2026	CC	denotes	and
T3950	2027-2031	RB	denotes	only
T3951	2032-2035	DT	denotes	the
T3952	2036-2042	JJ	denotes	former
T3953	2043-2049	VBD	denotes	showed
T3954	2050-2055	JJ	denotes	IL-10
T3955	2056-2066	NN	denotes	production
T3956	2066-2067	,	denotes	,
T3957	2068-2071	DT	denotes	the
T3958	2072-2083	NN	denotes	development
T3959	2084-2086	IN	denotes	of
T3960	2087-2091	JJ	denotes	high
T3961	2092-2107	JJ	denotes	IL-10-producing
T3962	2108-2113	NNS	denotes	cells
T3963	2114-2116	VBZ	denotes	is
T3964	2117-2121	RBS	denotes	most
T3965	2122-2128	JJ	denotes	likely
T3966	2129-2132	RB	denotes	not
T3967	2133-2140	VBN	denotes	related
T3968	2141-2143	TO	denotes	to
T3969	2144-2151	JJ	denotes	limited
T3970	2152-2156	NN	denotes	IL-2
T3971	2156-2157	.	denotes	.
T3972	2158-2163	JJ	denotes	Naive
T3973	2164-2167	NNP	denotes	CD4
T3974	2167-2168	CD	denotes	+
T3975	2169-2170	NNP	denotes	T
T3976	2171-2176	NNS	denotes	cells
T3977	2177-2181	IN	denotes	from
T3978	2182-2186	NNP	denotes	DO11
T3979	2186-2189	CD	denotes	.10
T3980	2189-2190	CD	denotes	/
T3981	2190-2214	JJ	denotes	recombination-activating
T3982	2215-2219	NN	denotes	gene
T3983	2220-2221	CD	denotes	1
T3984	2222-2223	-LRB-	denotes	(
T3985	2223-2227	NN	denotes	Rag1
T3986	2227-2228	-RRB-	denotes	)
T3987	2228-2229	:	denotes	-
T3988	2229-2238	NN	denotes	deficient
T3989	2239-2246	NNS	denotes	animals
T3990	2246-2247	,	denotes	,
T3991	2248-2256	VBN	denotes	cultured
T3992	2257-2261	IN	denotes	with
T3993	2262-2266	JJ	denotes	high
T3994	2267-2272	NNS	denotes	doses
T3995	2273-2275	IN	denotes	of
T3996	2276-2283	NN	denotes	antigen
T3997	2284-2286	IN	denotes	in
T3998	2287-2290	DT	denotes	the
T3999	2291-2299	NN	denotes	presence
T4000	2300-2302	IN	denotes	of
T4001	2303-2308	NN	denotes	IL-12
T4002	2308-2309	,	denotes	,
T4003	2310-2314	RB	denotes	also
T4004	2315-2323	VBD	denotes	resulted
T4005	2324-2326	IN	denotes	in
T4006	2327-2332	NNP	denotes	IL-10
T4007	2333-2343	NN	denotes	expression
T4008	2344-2346	IN	denotes	by
T4009	2347-2350	JJ	denotes	Th1
T4010	2351-2356	NNS	denotes	cells
T4011	2356-2357	,	denotes	,
T4012	2358-2365	VBG	denotes	showing
T4013	2366-2370	IN	denotes	that
T4014	2371-2375	DT	denotes	this
T4015	2376-2386	NN	denotes	expression
T4016	2387-2390	VBD	denotes	was
T4017	2391-2394	RB	denotes	not
T4018	2395-2404	JJ	denotes	dependent
T4019	2405-2407	IN	denotes	on
T4020	2408-2411	DT	denotes	the
T4021	2412-2420	NN	denotes	presence
T4022	2421-2423	IN	denotes	of
T4023	2424-2432	NN	denotes	effector
T4024	2433-2435	CC	denotes	or
T4025	2436-2442	NN	denotes	memory
T4026	2443-2444	NNP	denotes	T
T4027	2445-2450	NNS	denotes	cells
T4028	2451-2453	CC	denotes	or
T4029	2454-2458	NNP	denotes	Treg
T4030	2459-2464	NNS	denotes	cells
T4031	2465-2466	-LRB-	denotes	(
T4032	2466-2472	NN	denotes	Figure
T4033	2473-2475	CD	denotes	S2
T4034	2475-2476	-RRB-	denotes	)
T4035	2476-2477	.	denotes	.
T4036	2478-2486	IN	denotes	Although
T4037	2487-2489	PRP	denotes	it
T4038	2490-2493	VBZ	denotes	has
T4039	2494-2498	VBN	denotes	been
T4040	2499-2508	VBN	denotes	suggested
T4041	2509-2513	IN	denotes	that
T4042	2514-2519	NNP	denotes	TGF-β
T4043	2520-2523	MD	denotes	can
T4044	2524-2530	VB	denotes	induce
T4045	2531-2536	NNP	denotes	IL-10
T4046	2537-2539	IN	denotes	in
T4047	2540-2543	NNP	denotes	CD4
T4048	2543-2544	NNP	denotes	+
T4049	2545-2546	NNP	denotes	T
T4050	2547-2552	NNS	denotes	cells
T4051	2553-2554	-LRB-	denotes	(
T4052	2554-2560	NNP	denotes	Kitani
T4053	2561-2563	FW	denotes	et
T4054	2564-2567	FW	denotes	al.
T4055	2567-2568	,	denotes	,
T4056	2569-2573	CD	denotes	2003
T4057	2573-2574	:	denotes	;
T4058	2575-2582	NNP	denotes	Schiott
T4059	2583-2585	FW	denotes	et
T4060	2586-2589	FW	denotes	al.
T4061	2589-2590	,	denotes	,
T4062	2591-2595	CD	denotes	2000
T4063	2595-2596	-RRB-	denotes	)
T4064	2596-2597	,	denotes	,
T4065	2598-2600	PRP	denotes	we
T4066	2601-2606	VBD	denotes	found
T4067	2607-2611	IN	denotes	that
T4068	2612-2614	IN	denotes	in
T4069	2615-2625	VBG	denotes	developing
T4070	2626-2629	NNP	denotes	Th1
T4071	2630-2633	CC	denotes	and
T4072	2634-2637	NNP	denotes	Th2
T4073	2638-2643	NNS	denotes	cells
T4074	2644-2648	DT	denotes	this
T4075	2649-2652	VBD	denotes	was
T4076	2653-2656	RB	denotes	not
T4077	2657-2660	DT	denotes	the
T4078	2661-2665	NN	denotes	case
T4079	2666-2667	-LRB-	denotes	(
T4080	2667-2671	NNS	denotes	data
T4081	2672-2675	RB	denotes	not
T4082	2676-2681	VBN	denotes	shown
T4083	2681-2682	-RRB-	denotes	)
T4084	2682-2683	.	denotes	.
T4085	2684-2686	IN	denotes	In
T4086	2687-2691	NN	denotes	fact
T4087	2691-2692	,	denotes	,
T4088	2693-2707	NN	denotes	neutralization
T4089	2708-2710	IN	denotes	of
T4090	2711-2716	NNP	denotes	TGF-β
T4091	2717-2720	VBD	denotes	led
T4092	2721-2723	TO	denotes	to
T4093	2724-2733	VBN	denotes	increased
T4094	2734-2739	JJ	denotes	IL-10
T4095	2740-2750	NN	denotes	production
T4096	2751-2753	IN	denotes	by
T4097	2754-2758	DT	denotes	both
T4098	2759-2760	NNP	denotes	T
T4099	2761-2765	NN	denotes	cell
T4100	2766-2773	NNS	denotes	subsets
T4101	2774-2775	-LRB-	denotes	(
T4102	2775-2781	NN	denotes	Figure
T4103	2782-2784	CD	denotes	S3
T4104	2784-2785	-RRB-	denotes	)
T4105	2785-2786	.	denotes	.
T4106	2787-2791	RB	denotes	Thus
T4107	2791-2792	,	denotes	,
T4108	2793-2796	DT	denotes	the
T4109	2797-2808	NN	denotes	development
T4110	2809-2811	IN	denotes	of
T4111	2812-2827	JJ	denotes	IL-10-producing
T4112	2828-2831	JJ	denotes	Th1
T4113	2832-2837	NNS	denotes	cells
T4114	2838-2842	RB	denotes	only
T4115	2843-2851	VBD	denotes	depended
T4116	2852-2854	IN	denotes	on
T4117	2855-2858	DT	denotes	the
T4118	2859-2867	NN	denotes	presence
T4119	2868-2870	IN	denotes	of
T4120	2871-2876	NN	denotes	IL-12
T4121	2877-2885	RB	denotes	together
T4122	2886-2890	IN	denotes	with
T4123	2891-2895	JJ	denotes	high
T4124	2896-2903	NN	denotes	antigen
T4125	2904-2908	NN	denotes	dose
T4126	2909-2912	CC	denotes	and
T4127	2913-2916	RB	denotes	not
T4128	2917-2919	IN	denotes	on
T4129	2920-2925	JJ	denotes	other
T4130	2926-2933	JJ	denotes	soluble
T4131	2934-2941	NNS	denotes	factors
T4132	2942-2946	JJ	denotes	such
T4133	2947-2949	IN	denotes	as
T4134	2950-2954	NN	denotes	IL-2
T4135	2955-2957	CC	denotes	or
T4136	2958-2963	NN	denotes	TGF-β
T4137	2964-2966	CC	denotes	or
T4138	2967-2969	IN	denotes	on
T4139	2970-2973	DT	denotes	the
T4140	2974-2982	NN	denotes	presence
T4141	2983-2985	IN	denotes	of
T4142	2986-2991	JJ	denotes	other
T4143	2992-2993	NNP	denotes	T
T4144	2994-2998	NN	denotes	cell
T4145	2999-3004	NNS	denotes	types
T4146	3004-3005	.	denotes	.
R2726	T3574	T3589	nsubj	IL-12,study
R2727	T3575	T3574	cc	and,IL-12
R2728	T3576	T3577	amod	High,Doses
R2729	T3577	T3574	conj	Doses,IL-12
R2730	T3578	T3577	prep	of,Doses
R2731	T3579	T3580	compound	Antigen,Induce
R2732	T3580	T3578	pobj	Induce,of
R2733	T3581	T3582	det	the,Development
R2734	T3582	T3580	appos	Development,Induce
R2735	T3583	T3582	prep	of,Development
R2736	T3584	T3587	compound	Th1,IL-10
R2737	T3585	T3586	compound	Cells,Producing
R2738	T3586	T3587	compound	Producing,IL-10
R2739	T3587	T3583	pobj	IL-10,of
R2740	T3588	T3589	aux	To,study
R2741	T3589	T3601	ccomp	study,cultured
R2742	T3590	T3591	det	the,differentiation
R2743	T3591	T3589	dobj	differentiation,study
R2744	T3592	T3591	prep	of,differentiation
R2745	T3593	T3594	amod	Th1,cells
R2746	T3594	T3592	pobj	cells,of
R2747	T3595	T3589	advcl	coproducing,study
R2748	T3596	T3595	dobj	IFN-γ,coproducing
R2749	T3597	T3596	cc	and,IFN-γ
R2750	T3598	T3596	conj	IL-10,IFN-γ
R2751	T3599	T3601	punct	",",cultured
R2752	T3600	T3601	nsubj	we,cultured
R2753	T3601	T3601	ROOT	cultured,cultured
R2754	T3602	T3610	amod	purified,cells
R2755	T3603	T3610	amod	TCR-transgenic,cells
R2756	T3604	T3610	nmod	DO11,cells
R2757	T3605	T3604	nummod	.10,DO11
R2758	T3606	T3610	amod	naive,cells
R2759	T3607	T3610	compound	CD4,cells
R2760	T3608	T3610	nummod	+,cells
R2761	T3609	T3610	compound	T,cells
R2762	T3610	T3601	dobj	cells,cultured
R2763	T3611	T3610	prep	with,cells
R2764	T3612	T3613	amod	purified,DCs
R2765	T3613	T3611	pobj	DCs,with
R2766	T3614	T3601	prep	as,cultured
R2767	T3615	T3614	pobj	APCs,as
R2768	T3616	T3615	cc	and,APCs
R2769	T3617	T3618	amod	increasing,doses
R2770	T3618	T3615	conj	doses,APCs
R2771	T3619	T3618	prep	of,doses
R2772	T3620	T3621	compound	ovalbumin,peptide
R2773	T3621	T3619	pobj	peptide,of
R2774	T3622	T3621	nummod	323-339,peptide
R2775	T3623	T3624	punct	(,OVA
R2776	T3624	T3621	appos	OVA,peptide
R2777	T3625	T3601	punct	),cultured
R2778	T3626	T3601	punct	.,cultured
R2779	T3627	T3636	nsubj	Culture,gave
R2780	T3628	T3627	prep	with,Culture
R2781	T3629	T3630	amod	high,doses
R2782	T3630	T3628	pobj	doses,with
R2783	T3631	T3630	prep	of,doses
R2784	T3632	T3631	pobj	antigen,of
R2785	T3633	T3627	prep	for,Culture
R2786	T3634	T3635	nummod	7,days
R2787	T3635	T3633	pobj	days,for
R2788	T3636	T3636	ROOT	gave,gave
R2789	T3637	T3636	dobj	rise,gave
R2790	T3638	T3637	prep	to,rise
R2791	T3639	T3640	nummod	Th1,cells
R2792	T3640	T3638	pobj	cells,to
R2793	T3641	T3640	acl	expressing,cells
R2794	T3642	T3641	dobj	IFN-γ,expressing
R2795	T3643	T3641	prep	upon,expressing
R2796	T3644	T3643	pobj	restimulation,upon
R2797	T3645	T3648	punct	(,al.
R2798	T3646	T3648	amod	Constant,al.
R2799	T3647	T3648	nmod	et,al.
R2800	T3648	T3640	appos	al.,cells
R2801	T3649	T3648	punct	",",al.
R2802	T3650	T3648	npadvmod	1995,al.
R2803	T3651	T3638	punct	;,to
R2804	T3652	T3654	compound	Hosken,al.
R2805	T3653	T3654	compound	et,al.
R2806	T3654	T3637	appos	al.,rise
R2807	T3655	T3654	punct	",",al.
R2808	T3656	T3654	npadvmod	1995,al.
R2809	T3657	T3637	punct	),rise
R2810	T3658	T3636	punct	",",gave
R2811	T3659	T3636	cc	but,gave
R2812	T3660	T3664	neg	not,S1A
R2813	T3661	T3664	nmod	IL-10,S1A
R2814	T3662	T3664	punct	(,S1A
R2815	T3663	T3664	compound	Figure,S1A
R2816	T3664	T3636	conj	S1A,gave
R2817	T3665	T3666	amod	available,online
R2818	T3666	T3664	appos	online,S1A
R2819	T3667	T3664	punct	),S1A
R2820	T3668	T3664	punct	.,S1A
R2821	T3669	T3678	nsubj	Culture,led
R2822	T3670	T3669	prep	with,Culture
R2823	T3671	T3673	amod	low,doses
R2824	T3672	T3673	compound	antigen,doses
R2825	T3673	T3670	pobj	doses,with
R2826	T3674	T3673	prep	under,doses
R2827	T3675	T3677	det	the,conditions
R2828	T3676	T3677	amod	same,conditions
R2829	T3677	T3674	pobj	conditions,under
R2830	T3678	T3678	ROOT	led,led
R2831	T3679	T3678	prep	to,led
R2832	T3680	T3681	det	the,differentiation
R2833	T3681	T3679	pobj	differentiation,to
R2834	T3682	T3681	prep	of,differentiation
R2835	T3683	T3684	amod	Th2,cells
R2836	T3684	T3682	pobj	cells,of
R2837	T3685	T3681	punct	",",differentiation
R2838	T3686	T3687	nsubj	which,expressed
R2839	T3687	T3681	relcl	expressed,differentiation
R2840	T3688	T3689	det	both,IL-4
R2841	T3689	T3687	dobj	IL-4,expressed
R2842	T3690	T3689	cc	and,IL-4
R2843	T3691	T3689	conj	IL-10,IL-4
R2844	T3692	T3687	prep	upon,expressed
R2845	T3693	T3692	pobj	restimulation,upon
R2846	T3694	T3695	punct	(,Figure
R2847	T3695	T3693	appos	Figure,restimulation
R2848	T3696	T3695	nummod	S1A,Figure
R2849	T3697	T3695	punct	),Figure
R2850	T3698	T3678	punct	.,led
R2851	T3699	T3722	nsubj	Culture,resulted
R2852	T3700	T3699	prep	of,Culture
R2853	T3701	T3705	amod	naive,cells
R2854	T3702	T3705	compound	CD4,cells
R2855	T3703	T3705	nummod	+,cells
R2856	T3704	T3705	compound	T,cells
R2857	T3705	T3700	pobj	cells,of
R2858	T3706	T3699	prep	in,Culture
R2859	T3707	T3709	det	an,system
R2860	T3708	T3709	amod	APC-free,system
R2861	T3709	T3706	pobj	system,in
R2862	T3710	T3709	prep	by,system
R2863	T3711	T3710	pobj	stimulation,by
R2864	T3712	T3709	prep	with,system
R2865	T3713	T3716	amod	anti-CD3,antibodies
R2866	T3714	T3713	cc	and,anti-CD3
R2867	T3715	T3713	conj	anti-CD28,anti-CD3
R2868	T3716	T3712	pobj	antibodies,with
R2869	T3717	T3699	prep	in,Culture
R2870	T3718	T3719	det	the,presence
R2871	T3719	T3717	pobj	presence,in
R2872	T3720	T3719	prep	of,presence
R2873	T3721	T3720	pobj	IL-12,of
R2874	T3722	T3722	ROOT	resulted,resulted
R2875	T3723	T3722	prep	in,resulted
R2876	T3724	T3726	amod	IFN-γ-producing,cells
R2877	T3725	T3726	amod	Th1,cells
R2878	T3726	T3723	pobj	cells,in
R2879	T3727	T3722	punct	",",resulted
R2880	T3728	T3729	det	a,proportion
R2881	T3729	T3736	nsubj	proportion,did
R2882	T3730	T3729	prep	of,proportion
R2883	T3731	T3730	pobj	which,of
R2884	T3732	T3733	compound	coproduced,IL-10
R2885	T3733	T3729	appos	IL-10,proportion
R2886	T3734	T3736	punct	",",did
R2887	T3735	T3736	mark	as,did
R2888	T3736	T3722	conj	did,resulted
R2889	T3737	T3738	nummod	Th2,cells
R2890	T3738	T3736	dobj	cells,did
R2891	T3739	T3738	acl	resulting,cells
R2892	T3740	T3739	prep	from,resulting
R2893	T3741	T3740	pobj	culture,from
R2894	T3742	T3741	prep	in,culture
R2895	T3743	T3742	pobj	IL-4,in
R2896	T3744	T3745	punct	(,Figure
R2897	T3745	T3741	appos	Figure,culture
R2898	T3746	T3745	nummod	S1B,Figure
R2899	T3747	T3736	punct	),did
R2900	T3748	T3736	punct	.,did
R2901	T3749	T3750	aux	To,investigate
R2902	T3750	T3778	advcl	investigate,cultured
R2903	T3751	T3760	mark	whether,resulted
R2904	T3752	T3753	det	the,lack
R2905	T3753	T3760	nsubj	lack,resulted
R2906	T3754	T3753	prep	of,lack
R2907	T3755	T3754	pobj	IL-10,of
R2908	T3756	T3755	acl	produced,IL-10
R2909	T3757	T3756	agent	by,produced
R2910	T3758	T3759	amod	Th1,cells
R2911	T3759	T3757	pobj	cells,by
R2912	T3760	T3750	ccomp	resulted,investigate
R2913	T3761	T3760	prep	from,resulted
R2914	T3762	T3761	pobj	inhibition,from
R2915	T3763	T3762	prep	of,inhibition
R2916	T3764	T3765	compound	IL-10,production
R2917	T3765	T3763	pobj	production,of
R2918	T3766	T3765	prep	by,production
R2919	T3767	T3766	pobj	DCs,by
R2920	T3768	T3767	cc	and,DCs
R2921	T3769	T3770	amod	high,antigen
R2922	T3770	T3771	compound	antigen,dose
R2923	T3771	T3765	conj	dose,production
R2924	T3772	T3760	cc	or,resulted
R2925	T3773	T3774	advmod	alternatively,required
R2926	T3774	T3760	conj	required,resulted
R2927	T3775	T3774	dobj	IL-12,required
R2928	T3776	T3778	punct	",",cultured
R2929	T3777	T3778	nsubj	we,cultured
R2930	T3778	T3778	ROOT	cultured,cultured
R2931	T3779	T3783	amod	naive,cells
R2932	T3780	T3783	compound	CD4,cells
R2933	T3781	T3783	nummod	+,cells
R2934	T3782	T3783	compound	T,cells
R2935	T3783	T3778	dobj	cells,cultured
R2936	T3784	T3778	prep	with,cultured
R2937	T3785	T3786	amod	increasing,doses
R2938	T3786	T3784	pobj	doses,with
R2939	T3787	T3786	prep	of,doses
R2940	T3788	T3787	pobj	antigen,of
R2941	T3789	T3788	acl	presented,antigen
R2942	T3790	T3789	agent	by,presented
R2943	T3791	T3790	pobj	DC,by
R2944	T3792	T3789	prep	in,presented
R2945	T3793	T3794	det	the,presence
R2946	T3794	T3792	pobj	presence,in
R2947	T3795	T3794	prep	of,presence
R2948	T3796	T3795	pobj	IL-12,of
R2949	T3797	T3778	punct	.,cultured
R2950	T3798	T3805	prep	At,abrogated
R2951	T3799	T3800	amod	low,doses
R2952	T3800	T3798	pobj	doses,At
R2953	T3801	T3800	prep	of,doses
R2954	T3802	T3801	pobj	antigen,of
R2955	T3803	T3805	punct	",",abrogated
R2956	T3804	T3805	nsubj	IL-12,abrogated
R2957	T3805	T3805	ROOT	abrogated,abrogated
R2958	T3806	T3807	det	the,development
R2959	T3807	T3805	dobj	development,abrogated
R2960	T3808	T3807	prep	of,development
R2961	T3809	T3810	amod	Th2,cells
R2962	T3810	T3808	pobj	cells,of
R2963	T3811	T3805	cc	and,abrogated
R2964	T3812	T3805	conj	induced,abrogated
R2965	T3813	T3814	amod	IFN-γ,expression
R2966	T3814	T3812	dobj	expression,induced
R2967	T3815	T3812	cc	but,induced
R2968	T3816	T3818	advmod	only,levels
R2969	T3817	T3818	amod	low,levels
R2970	T3818	T3812	conj	levels,induced
R2971	T3819	T3818	prep	of,levels
R2972	T3820	T3821	compound	IL-10,expression
R2973	T3821	T3819	pobj	expression,of
R2974	T3822	T3812	punct	",",induced
R2975	T3823	T3812	advcl	suggesting,induced
R2976	T3824	T3828	mark	that,was
R2977	T3825	T3827	amod	IL-12,se
R2978	T3826	T3827	advmod	per,se
R2979	T3827	T3828	nsubj	se,was
R2980	T3828	T3823	ccomp	was,suggesting
R2981	T3829	T3828	neg	not,was
R2982	T3830	T3828	acomp	sufficient,was
R2983	T3831	T3832	aux	to,induce
R2984	T3832	T3830	xcomp	induce,sufficient
R2985	T3833	T3835	amod	significant,production
R2986	T3834	T3835	compound	IL-10,production
R2987	T3835	T3832	dobj	production,induce
R2988	T3836	T3835	prep	in,production
R2989	T3837	T3838	amod	Th1,cells
R2990	T3838	T3836	pobj	cells,in
R2991	T3839	T3840	punct	(,Figure
R2992	T3840	T3835	appos	Figure,production
R2993	T3841	T3840	nummod	1A,Figure
R2994	T3842	T3840	punct	),Figure
R2995	T3843	T3805	punct	.,abrogated
R2996	T3844	T3855	advmod	Strikingly,driven
R2997	T3845	T3855	punct	",",driven
R2998	T3846	T3851	mark	as,increased
R2999	T3847	T3849	det	the,dose
R3000	T3848	T3849	compound	antigen,dose
R3001	T3849	T3851	nsubjpass	dose,increased
R3002	T3850	T3851	auxpass	was,increased
R3003	T3851	T3855	advcl	increased,driven
R3004	T3852	T3855	punct	",",driven
R3005	T3853	T3854	amod	Th1,populations
R3006	T3854	T3855	nsubj	populations,driven
R3007	T3855	T3855	ROOT	driven,driven
R3008	T3856	T3855	prep	with,driven
R3009	T3857	T3856	pobj	IL-12,with
R3010	T3858	T3855	advmod	now,driven
R3011	T3859	T3855	conj	contained,driven
R3012	T3860	T3861	amod	higher,numbers
R3013	T3861	T3859	dobj	numbers,contained
R3014	T3862	T3861	prep	of,numbers
R3015	T3863	T3864	amod	IL-10-producing,cells
R3016	T3864	T3862	pobj	cells,of
R3017	T3865	T3866	punct	(,Figure
R3018	T3866	T3861	appos	Figure,numbers
R3019	T3867	T3866	nummod	1A,Figure
R3020	T3868	T3866	punct	),Figure
R3021	T3869	T3859	cc	and,contained
R3022	T3870	T3859	conj	produced,contained
R3023	T3871	T3873	amod	more,protein
R3024	T3872	T3873	amod	IL-10,protein
R3025	T3873	T3870	dobj	protein,produced
R3026	T3874	T3873	prep	upon,protein
R3027	T3875	T3874	pobj	restimulation,upon
R3028	T3876	T3878	punct	(,1A
R3029	T3877	T3878	compound	Figures,1A
R3030	T3878	T3873	appos	1A,protein
R3031	T3879	T3878	cc	and,1A
R3032	T3880	T3878	conj	1B,1A
R3033	T3881	T3878	punct	),1A
R3034	T3882	T3855	punct	.,driven
R3035	T3883	T3892	advmod	Thus,required
R3036	T3884	T3892	punct	",",required
R3037	T3885	T3886	det	the,development
R3038	T3886	T3892	nsubj	development,required
R3039	T3887	T3886	prep	of,development
R3040	T3888	T3889	amod	Th1,cells
R3041	T3889	T3887	pobj	cells,of
R3042	T3890	T3889	acl	producing,cells
R3043	T3891	T3890	dobj	IL-10,producing
R3044	T3892	T3892	ROOT	required,required
R3045	T3893	T3894	preconj	both,IL-12
R3046	T3894	T3892	dobj	IL-12,required
R3047	T3895	T3894	cc	and,IL-12
R3048	T3962	T3959	pobj	cells,of
R3049	T3896	T3897	amod	high,doses
R3050	T3963	T3953	conj	is,showed
R3051	T3897	T3894	conj	doses,IL-12
R3052	T3898	T3897	prep	of,doses
R3053	T3964	T3965	advmod	most,likely
R3054	T3899	T3898	pobj	antigen,of
R3055	T3900	T3892	punct	.,required
R3056	T3965	T3963	acomp	likely,is
R3057	T3901	T3902	nummod	Th1,cells
R3058	T3902	T3913	nsubj	cells,lost
R3059	T3903	T3902	acl	differentiated,cells
R3060	T3966	T3967	neg	not,related
R3061	T3904	T3905	aux	to,produce
R3062	T3905	T3903	advcl	produce,differentiated
R3063	T3906	T3907	amod	large,amounts
R3064	T3967	T3963	acomp	related,is
R3065	T3907	T3905	dobj	amounts,produce
R3066	T3908	T3907	prep	of,amounts
R3067	T3909	T3908	pobj	IL-10,of
R3068	T3968	T3967	prep	to,related
R3069	T3910	T3909	cc	and,IL-10
R3070	T3911	T3909	conj	IFN-γ,IL-10
R3071	T3969	T3970	amod	limited,IL-2
R3072	T3912	T3903	cc	and,differentiated
R3073	T3913	T3913	ROOT	lost,lost
R3074	T3970	T3968	pobj	IL-2,to
R3075	T3971	T3953	punct	.,showed
R3076	T3914	T3915	poss	their,capacity
R3077	T3972	T3976	amod	Naive,cells
R3078	T3973	T3976	compound	CD4,cells
R3079	T3915	T3913	dobj	capacity,lost
R3080	T3974	T3976	nummod	+,cells
R3081	T3975	T3976	compound	T,cells
R3082	T3916	T3917	aux	to,produce
R3083	T3976	T4004	nsubj	cells,resulted
R3084	T3977	T3976	prep	from,cells
R3085	T3917	T3915	acl	produce,capacity
R3086	T3918	T3917	dobj	IL-2,produce
R3087	T3978	T3977	pobj	DO11,from
R3088	T3919	T3921	punct	(,1B
R3089	T3920	T3921	compound	Figure,1B
R3090	T3921	T3918	appos	1B,IL-2
R3091	T3922	T3921	punct	),1B
R3092	T3979	T3978	nummod	.10,DO11
R3093	T3923	T3913	punct	.,lost
R3094	T3924	T3929	mark	Because,reduced
R3095	T3980	T3989	nummod	/,animals
R3096	T3925	T3926	det	the,presence
R3097	T3926	T3929	nsubj	presence,reduced
R3098	T3927	T3926	prep	of,presence
R3099	T3928	T3927	pobj	IL-12,of
R3100	T3981	T3982	compound	recombination-activating,gene
R3101	T3929	T3929	ROOT	reduced,reduced
R3102	T3930	T3931	det	the,proliferation
R3103	T3931	T3929	dobj	proliferation,reduced
R3104	T3982	T3988	npadvmod	gene,deficient
R3105	T3932	T3931	prep	of,proliferation
R3106	T3933	T3936	nummod	CD4,cells
R3107	T3934	T3936	nummod	+,cells
R3108	T3983	T3982	nummod	1,gene
R3109	T3935	T3936	compound	T,cells
R3110	T3936	T3932	pobj	cells,of
R3111	T3984	T3985	punct	(,Rag1
R3112	T3937	T3929	prep	at,reduced
R3113	T3938	T3939	preconj	both,high
R3114	T3939	T3943	amod	high,doses
R3115	T3940	T3939	cc	and,high
R3116	T3985	T3982	appos	Rag1,gene
R3117	T3941	T3939	conj	low,high
R3118	T3942	T3943	compound	antigen,doses
R3119	T3986	T3985	punct	),Rag1
R3120	T3943	T3937	pobj	doses,at
R3121	T3944	T3946	punct	(,S1
R3122	T3945	T3946	compound	Table,S1
R3123	T3987	T3988	punct	-,deficient
R3124	T3946	T3943	appos	S1,doses
R3125	T3988	T3989	amod	deficient,animals
R3126	T3989	T3976	conj	animals,cells
R3127	T3947	T3946	punct	),S1
R3128	T3948	T3929	punct	",",reduced
R3129	T3990	T3989	punct	",",animals
R3130	T3949	T3929	cc	and,reduced
R3131	T3950	T3953	advmod	only,showed
R3132	T3951	T3952	det	the,former
R3133	T3991	T3976	acl	cultured,cells
R3134	T3952	T3953	nsubj	former,showed
R3135	T3953	T3929	conj	showed,reduced
R3136	T3954	T3955	amod	IL-10,production
R3137	T3955	T3953	dobj	production,showed
R3138	T3956	T3953	punct	",",showed
R3139	T3992	T3991	prep	with,cultured
R3140	T3957	T3958	det	the,development
R3141	T3958	T3963	nsubj	development,is
R3142	T3993	T3994	amod	high,doses
R3143	T3959	T3958	prep	of,development
R3144	T3960	T3962	amod	high,cells
R3145	T3961	T3962	amod	IL-10-producing,cells
R3146	T3994	T3992	pobj	doses,with
R3147	T3995	T3994	prep	of,doses
R3148	T3996	T3995	pobj	antigen,of
R3149	T3997	T3991	prep	in,cultured
R3150	T3998	T3999	det	the,presence
R3151	T4090	T4089	pobj	TGF-β,of
R3152	T4091	T4091	ROOT	led,led
R3153	T3999	T3997	pobj	presence,in
R3154	T4092	T4091	prep	to,led
R3155	T4093	T4095	amod	increased,production
R3156	T4094	T4095	amod	IL-10,production
R3157	T4000	T3999	prep	of,presence
R3158	T4095	T4092	pobj	production,to
R3159	T4096	T4095	prep	by,production
R3160	T4097	T4100	det	both,subsets
R3161	T4098	T4099	compound	T,cell
R3162	T4001	T4000	pobj	IL-12,of
R3163	T4099	T4100	compound	cell,subsets
R3164	T4100	T4096	pobj	subsets,by
R3165	T4002	T3976	punct	",",cells
R3166	T4101	T4102	punct	(,Figure
R3167	T4003	T4004	advmod	also,resulted
R3168	T4102	T4100	appos	Figure,subsets
R3169	T4103	T4102	nummod	S3,Figure
R3170	T4104	T4102	punct	),Figure
R3171	T4004	T4004	ROOT	resulted,resulted
R3172	T4105	T4091	punct	.,led
R3173	T4106	T4115	advmod	Thus,depended
R3174	T4107	T4115	punct	",",depended
R3175	T4005	T4004	prep	in,resulted
R3176	T4108	T4109	det	the,development
R3177	T4109	T4115	nsubj	development,depended
R3178	T4110	T4109	prep	of,development
R3179	T4006	T4007	compound	IL-10,expression
R3180	T4111	T4113	amod	IL-10-producing,cells
R3181	T4112	T4113	amod	Th1,cells
R3182	T4113	T4110	pobj	cells,of
R3183	T4007	T4005	pobj	expression,in
R3184	T4114	T4115	advmod	only,depended
R3185	T4115	T4115	ROOT	depended,depended
R3186	T4116	T4115	prep	on,depended
R3187	T4117	T4118	det	the,presence
R3188	T4008	T4004	prep	by,resulted
R3189	T4118	T4116	pobj	presence,on
R3190	T4119	T4118	prep	of,presence
R3191	T4009	T4010	amod	Th1,cells
R3192	T4120	T4119	pobj	IL-12,of
R3193	T4121	T4122	advmod	together,with
R3194	T4122	T4115	prep	with,depended
R3195	T4010	T4008	pobj	cells,by
R3196	T4123	T4125	amod	high,dose
R3197	T4124	T4125	compound	antigen,dose
R3198	T4125	T4122	pobj	dose,with
R3199	T4011	T4004	punct	",",resulted
R3200	T4126	T4125	cc	and,dose
R3201	T4127	T4128	neg	not,on
R3202	T4012	T4004	advcl	showing,resulted
R3203	T4128	T4115	prep	on,depended
R3204	T4129	T4131	amod	other,factors
R3205	T4013	T4016	mark	that,was
R3206	T4130	T4131	amod	soluble,factors
R3207	T4131	T4128	pobj	factors,on
R3208	T4132	T4133	amod	such,as
R3209	T4133	T4131	prep	as,factors
R3210	T4014	T4015	det	this,expression
R3211	T4134	T4133	pobj	IL-2,as
R3212	T4135	T4134	cc	or,IL-2
R3213	T4136	T4134	conj	TGF-β,IL-2
R3214	T4015	T4016	nsubj	expression,was
R3215	T4137	T4128	cc	or,on
R3216	T4138	T4128	conj	on,on
R3217	T4139	T4140	det	the,presence
R3218	T4016	T4012	ccomp	was,showing
R3219	T4140	T4138	pobj	presence,on
R3220	T4141	T4140	prep	of,presence
R3221	T4017	T4018	neg	not,dependent
R3222	T4142	T4145	amod	other,types
R3223	T4143	T4145	compound	T,types
R3224	T4144	T4145	compound	cell,types
R3225	T4145	T4141	pobj	types,of
R3226	T4018	T4016	acomp	dependent,was
R3227	T4146	T4115	punct	.,depended
R3228	T4019	T4018	prep	on,dependent
R3229	T4020	T4021	det	the,presence
R3230	T4021	T4019	pobj	presence,on
R3231	T4022	T4021	prep	of,presence
R3232	T4023	T4022	pobj	effector,of
R3233	T4024	T4023	cc	or,effector
R3234	T4025	T4027	compound	memory,cells
R3235	T4026	T4027	compound	T,cells
R3236	T4027	T4023	conj	cells,effector
R3237	T4028	T4027	cc	or,cells
R3238	T4029	T4030	compound	Treg,cells
R3239	T4030	T4027	conj	cells,cells
R3240	T4031	T4032	punct	(,Figure
R3241	T4032	T4021	appos	Figure,presence
R3242	T4033	T4032	nummod	S2,Figure
R3243	T4034	T4032	punct	),Figure
R3244	T4035	T4004	punct	.,resulted
R3245	T4036	T4040	mark	Although,suggested
R3246	T4037	T4040	nsubjpass	it,suggested
R3247	T4038	T4040	aux	has,suggested
R3248	T4039	T4040	auxpass	been,suggested
R3249	T4040	T4066	advcl	suggested,found
R3250	T4041	T4044	mark	that,induce
R3251	T4042	T4044	nsubj	TGF-β,induce
R3252	T4043	T4044	aux	can,induce
R3253	T4044	T4040	ccomp	induce,suggested
R3254	T4045	T4044	dobj	IL-10,induce
R3255	T4046	T4044	prep	in,induce
R3256	T4047	T4050	nmod	CD4,cells
R3257	T4048	T4050	nmod	+,cells
R3258	T4049	T4050	compound	T,cells
R3259	T4050	T4046	pobj	cells,in
R3260	T4051	T4054	punct	(,al.
R3261	T4052	T4054	compound	Kitani,al.
R3262	T4053	T4054	nmod	et,al.
R3263	T4054	T4044	parataxis	al.,induce
R3264	T4055	T4054	punct	",",al.
R3265	T4056	T4054	npadvmod	2003,al.
R3266	T4057	T4044	punct	;,induce
R3267	T4058	T4060	compound	Schiott,al.
R3268	T4059	T4060	compound	et,al.
R3269	T4060	T4040	oprd	al.,suggested
R3270	T4061	T4060	punct	",",al.
R3271	T4062	T4060	appos	2000,al.
R3272	T4063	T4060	punct	),al.
R3273	T4064	T4066	punct	",",found
R3274	T4065	T4066	nsubj	we,found
R3275	T4066	T4066	ROOT	found,found
R3276	T4067	T4075	mark	that,was
R3277	T4068	T4075	prep	in,was
R3278	T4069	T4068	pcomp	developing,in
R3279	T4070	T4073	nmod	Th1,cells
R3280	T4071	T4070	cc	and,Th1
R3281	T4072	T4070	conj	Th2,Th1
R3282	T4073	T4069	dobj	cells,developing
R3283	T4074	T4075	nsubj	this,was
R3284	T4075	T4066	ccomp	was,found
R3285	T4076	T4075	neg	not,was
R3286	T4077	T4078	det	the,case
R3287	T4078	T4075	attr	case,was
R3288	T4079	T4082	punct	(,shown
R3289	T4080	T4082	nsubjpass	data,shown
R3290	T4081	T4082	neg	not,shown
R3291	T4082	T4075	conj	shown,was
R3292	T4083	T4082	punct	),shown
R3293	T4084	T4066	punct	.,found
R3294	T4085	T4091	prep	In,led
R3295	T4086	T4085	pobj	fact,In
R3297	T4087	T4091	punct	",",led
R3299	T4088	T4091	nsubj	neutralization,led
R3301	T4089	T4088	prep	of,neutralization

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T4162	43-54	http://purl.obolibrary.org/obo/GO_0032502	denotes	Development
T4163	1257-1268	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T4164	1694-1705	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T4165	2072-2083	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T4166	2797-2808	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T4167	176-179	http://purl.obolibrary.org/obo/GO_0006283	denotes	TCR
T4168	1027-1043	http://purl.obolibrary.org/obo/GO_0032653	denotes	IL-10 production
T4169	1422-1438	http://purl.obolibrary.org/obo/GO_0032653	denotes	IL-10 production
T4170	2050-2066	http://purl.obolibrary.org/obo/GO_0032653	denotes	IL-10 production
T4171	2734-2750	http://purl.obolibrary.org/obo/GO_0032653	denotes	IL-10 production
T4172	1027-1043	http://purl.obolibrary.org/obo/GO_0032613	denotes	IL-10 production
T4173	1422-1438	http://purl.obolibrary.org/obo/GO_0032613	denotes	IL-10 production
T4174	2050-2066	http://purl.obolibrary.org/obo/GO_0032613	denotes	IL-10 production
T4175	2734-2750	http://purl.obolibrary.org/obo/GO_0032613	denotes	IL-10 production
T4176	1786-1806	http://purl.obolibrary.org/obo/GO_0030154	denotes	cells differentiated
T4177	2436-2442	http://purl.obolibrary.org/obo/GO_0007613	denotes	memory

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T4178	0-5	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T4179	789-794	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T4180	1099-1104	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T4181	1205-1210	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T4182	1237-1242	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T4183	1368-1373	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T4184	1540-1545	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T4185	1749-1754	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T4186	1928-1933	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T4187	2303-2308	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T4188	2871-2876	http://purl.obolibrary.org/obo/GO_0005143	denotes	IL-12
T4189	78-83	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4190	148-153	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4191	460-465	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4192	625-630	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4193	867-872	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4194	971-976	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4195	1027-1032	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4196	1334-1339	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4197	1422-1427	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4198	1578-1583	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4199	1630-1635	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4200	1729-1734	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4201	1835-1840	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4202	2050-2055	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4203	2092-2097	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4204	2327-2332	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4205	2531-2536	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4206	2734-2739	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4207	2812-2817	http://purl.obolibrary.org/obo/GO_0005141	denotes	IL-10
T4208	616-620	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T4209	917-921	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T4210	759-769	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibodies
T4211	1886-1890	http://purl.obolibrary.org/obo/GO_0005134	denotes	IL-2
T4212	2152-2156	http://purl.obolibrary.org/obo/GO_0005134	denotes	IL-2
T4213	2950-2954	http://purl.obolibrary.org/obo/GO_0005134	denotes	IL-2

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T4214	120-125	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4215	212-217	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4216	364-369	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4217	588-593	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4218	688-693	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4219	827-832	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4220	885-890	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4221	993-998	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4222	1131-1136	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4223	1276-1281	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4224	1446-1451	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4225	1594-1599	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4226	1713-1718	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4227	1786-1791	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4228	1970-1975	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4229	2108-2113	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4230	2171-2176	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4231	2351-2356	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4232	2445-2450	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4233	2459-2464	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4234	2547-2552	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4235	2638-2643	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4236	2832-2837	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T4237	2994-2998	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T4238	176-179	http://purl.obolibrary.org/obo/GO_0042101	denotes	TCR
T4239	700-703	http://purl.obolibrary.org/obo/GO_0005680	denotes	APC
T4240	759-769	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibodies
T4241	759-769	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibodies

sentences

Id	Subject	Object	Predicate	Lexical cue
T2963	0-83	Sentence	denotes	IL-12 and High Doses of Antigen Induce the Development of Th1 Cells Producing IL-10
T2964	84-300	Sentence	denotes	To study the differentiation of Th1 cells coproducing IFN-γ and IL-10, we cultured purified TCR-transgenic DO11.10 naive CD4+ T cells with purified DCs as APCs and increasing doses of ovalbumin peptide 323-339 (OVA).
T2965	301-496	Sentence	denotes	Culture with high doses of antigen for 7 days gave rise to Th1 cells expressing IFN-γ upon restimulation (Constant et al., 1995; Hosken et al., 1995), but not IL-10 (Figure S1A available online).
T2966	497-663	Sentence	denotes	Culture with low antigen doses under the same conditions led to the differentiation of Th2 cells, which expressed both IL-4 and IL-10 upon restimulation (Figure S1A).
T2967	664-935	Sentence	denotes	Culture of naive CD4+ T cells in an APC-free system by stimulation with anti-CD3 and anti-CD28 antibodies in the presence of IL-12 resulted in IFN-γ-producing Th1 cells, a proportion of which coproduced IL-10, as did Th2 cells resulting from culture in IL-4 (Figure S1B).
T2968	936-1211	Sentence	denotes	To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12.
T2969	1212-1464	Sentence	denotes	At low doses of antigen, IL-12 abrogated the development of Th2 cells and induced IFN-γ expression but only low levels of IL-10 expression, suggesting that IL-12 per se was not sufficient to induce significant IL-10 production in Th1 cells (Figure 1A).
T2970	1465-1683	Sentence	denotes	Strikingly, as the antigen dose was increased, Th1 populations driven with IL-12 now contained higher numbers of IL-10-producing cells (Figure 1A) and produced more IL-10 protein upon restimulation (Figures 1A and 1B).
T2971	1684-1781	Sentence	denotes	Thus, the development of Th1 cells producing IL-10 required both IL-12 and high doses of antigen.
T2972	1782-1903	Sentence	denotes	Th1 cells differentiated to produce large amounts of IL-10 and IFN-γ and lost their capacity to produce IL-2 (Figure 1B).
T2973	1904-2157	Sentence	denotes	Because the presence of IL-12 reduced the proliferation of CD4+ T cells at both high and low antigen doses (Table S1), and only the former showed IL-10 production, the development of high IL-10-producing cells is most likely not related to limited IL-2.
T2974	2158-2477	Sentence	denotes	Naive CD4+ T cells from DO11.10/recombination-activating gene 1 (Rag1)-deficient animals, cultured with high doses of antigen in the presence of IL-12, also resulted in IL-10 expression by Th1 cells, showing that this expression was not dependent on the presence of effector or memory T cells or Treg cells (Figure S2).
T2975	2478-2683	Sentence	denotes	Although it has been suggested that TGF-β can induce IL-10 in CD4+ T cells (Kitani et al., 2003; Schiott et al., 2000), we found that in developing Th1 and Th2 cells this was not the case (data not shown).
T2976	2684-2786	Sentence	denotes	In fact, neutralization of TGF-β led to increased IL-10 production by both T cell subsets (Figure S3).
T2977	2787-3005	Sentence	denotes	Thus, the development of IL-10-producing Th1 cells only depended on the presence of IL-12 together with high antigen dose and not on other soluble factors such as IL-2 or TGF-β or on the presence of other T cell types.
T31	0-83	Sentence	denotes	IL-12 and High Doses of Antigen Induce the Development of Th1 Cells Producing IL-10
T32	84-300	Sentence	denotes	To study the differentiation of Th1 cells coproducing IFN-γ and IL-10, we cultured purified TCR-transgenic DO11.10 naive CD4+ T cells with purified DCs as APCs and increasing doses of ovalbumin peptide 323-339 (OVA).
T33	301-496	Sentence	denotes	Culture with high doses of antigen for 7 days gave rise to Th1 cells expressing IFN-γ upon restimulation (Constant et al., 1995; Hosken et al., 1995), but not IL-10 (Figure S1A available online).
T34	497-663	Sentence	denotes	Culture with low antigen doses under the same conditions led to the differentiation of Th2 cells, which expressed both IL-4 and IL-10 upon restimulation (Figure S1A).
T35	664-935	Sentence	denotes	Culture of naive CD4+ T cells in an APC-free system by stimulation with anti-CD3 and anti-CD28 antibodies in the presence of IL-12 resulted in IFN-γ-producing Th1 cells, a proportion of which coproduced IL-10, as did Th2 cells resulting from culture in IL-4 (Figure S1B).
T36	936-1211	Sentence	denotes	To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12.
T37	1212-1464	Sentence	denotes	At low doses of antigen, IL-12 abrogated the development of Th2 cells and induced IFN-γ expression but only low levels of IL-10 expression, suggesting that IL-12 per se was not sufficient to induce significant IL-10 production in Th1 cells (Figure 1A).
T38	1465-1683	Sentence	denotes	Strikingly, as the antigen dose was increased, Th1 populations driven with IL-12 now contained higher numbers of IL-10-producing cells (Figure 1A) and produced more IL-10 protein upon restimulation (Figures 1A and 1B).
T39	1684-1781	Sentence	denotes	Thus, the development of Th1 cells producing IL-10 required both IL-12 and high doses of antigen.
T40	1782-1903	Sentence	denotes	Th1 cells differentiated to produce large amounts of IL-10 and IFN-γ and lost their capacity to produce IL-2 (Figure 1B).
T41	1904-2157	Sentence	denotes	Because the presence of IL-12 reduced the proliferation of CD4+ T cells at both high and low antigen doses (Table S1), and only the former showed IL-10 production, the development of high IL-10-producing cells is most likely not related to limited IL-2.
T42	2158-2477	Sentence	denotes	Naive CD4+ T cells from DO11.10/recombination-activating gene 1 (Rag1)-deficient animals, cultured with high doses of antigen in the presence of IL-12, also resulted in IL-10 expression by Th1 cells, showing that this expression was not dependent on the presence of effector or memory T cells or Treg cells (Figure S2).
T43	2478-2683	Sentence	denotes	Although it has been suggested that TGF-β can induce IL-10 in CD4+ T cells (Kitani et al., 2003; Schiott et al., 2000), we found that in developing Th1 and Th2 cells this was not the case (data not shown).
T44	2684-2786	Sentence	denotes	In fact, neutralization of TGF-β led to increased IL-10 production by both T cell subsets (Figure S3).
T45	2787-3005	Sentence	denotes	Thus, the development of IL-10-producing Th1 cells only depended on the presence of IL-12 together with high antigen dose and not on other soluble factors such as IL-2 or TGF-β or on the presence of other T cell types.

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T4448	0-5	Protein	denotes	IL-12
T4449	68-77	Gene_expression	denotes	Producing
T4450	78-83	Protein	denotes	IL-10
T4451	126-137	Gene_expression	denotes	coproducing
T4452	126-137	Gene_expression	denotes	coproducing
T4453	138-143	Protein	denotes	IFN-γ
T4454	148-153	Protein	denotes	IL-10
T4455	205-208	Protein	denotes	CD4
T4456	268-277	Protein	denotes	ovalbumin
T4457	295-298	Protein	denotes	OVA
T4458	352-356	Positive_regulation	denotes	rise
T4459	352-356	Positive_regulation	denotes	rise
T4460	370-380	Gene_expression	denotes	expressing	true
T4461	370-380	Gene_expression	denotes	expressing
T4462	381-386	Protein	denotes	IFN-γ
T4463	460-465	Protein	denotes	IL-10
T4464	601-610	Gene_expression	denotes	expressed
T4465	601-610	Gene_expression	denotes	expressed
T4466	616-620	Protein	denotes	IL-4
T4467	625-630	Protein	denotes	IL-10
T4468	681-684	Protein	denotes	CD4
T4469	741-744	Protein	denotes	CD3
T4470	754-758	Protein	denotes	CD28
T4471	789-794	Protein	denotes	IL-12
T4472	795-803	Positive_regulation	denotes	resulted
T4473	795-803	Positive_regulation	denotes	resulted
T4474	807-812	Protein	denotes	IFN-γ
T4475	813-822	Gene_expression	denotes	producing
T4476	856-866	Gene_expression	denotes	coproduced
T4477	867-872	Protein	denotes	IL-10
T4478	917-921	Protein	denotes	IL-4
T4479	963-967	Negative_regulation	denotes	lack
T4480	971-976	Protein	denotes	IL-10
T4481	977-985	Gene_expression	denotes	produced
T4482	999-1007	Positive_regulation	denotes	resulted		true
T4483	1013-1023	Negative_regulation	denotes	inhibition
T4484	1027-1032	Protein	denotes	IL-10
T4485	1033-1043	Gene_expression	denotes	production
T4486	1099-1104	Protein	denotes	IL-12
T4487	1124-1127	Protein	denotes	CD4
T4488	1205-1210	Protein	denotes	IL-12
T4489	1237-1242	Protein	denotes	IL-12
T4490	1286-1293	Positive_regulation	denotes	induced
T4491	1286-1293	Positive_regulation	denotes	induced
T4492	1294-1299	Protein	denotes	IFN-γ
T4493	1300-1310	Gene_expression	denotes	expression
T4494	1334-1339	Protein	denotes	IL-10
T4495	1340-1350	Gene_expression	denotes	expression
T4496	1368-1373	Protein	denotes	IL-12
T4497	1403-1409	Positive_regulation	denotes	induce	true	true
T4498	1422-1427	Protein	denotes	IL-10
T4499	1428-1438	Gene_expression	denotes	production
T4500	1540-1545	Protein	denotes	IL-12
T4501	1578-1583	Protein	denotes	IL-10
T4502	1584-1593	Gene_expression	denotes	producing
T4503	1616-1624	Gene_expression	denotes	produced
T4504	1625-1629	Positive_regulation	denotes	more
T4505	1630-1635	Protein	denotes	IL-10
T4506	1719-1728	Gene_expression	denotes	producing
T4507	1729-1734	Protein	denotes	IL-10
T4508	1735-1743	Positive_regulation	denotes	required
T4509	1749-1754	Protein	denotes	IL-12
T4510	1810-1817	Gene_expression	denotes	produce
T4511	1810-1817	Gene_expression	denotes	produce
T4512	1835-1840	Protein	denotes	IL-10
T4513	1845-1850	Protein	denotes	IFN-γ
T4514	1855-1859	Negative_regulation	denotes	lost
T4515	1878-1885	Gene_expression	denotes	produce
T4516	1886-1890	Protein	denotes	IL-2
T4517	1928-1933	Protein	denotes	IL-12
T4518	1963-1966	Protein	denotes	CD4
T4519	2050-2055	Protein	denotes	IL-10
T4520	2056-2066	Gene_expression	denotes	production
T4521	2092-2097	Protein	denotes	IL-10
T4522	2098-2107	Gene_expression	denotes	producing
T4523	2144-2151	Negative_regulation	denotes	limited
T4524	2152-2156	Protein	denotes	IL-2
T4525	2164-2167	Protein	denotes	CD4
T4526	2190-2221	Protein	denotes	recombination-activating gene 1
T4527	2223-2227	Protein	denotes	Rag1
T4528	2229-2238	Negative_regulation	denotes	deficient
T4529	2303-2308	Protein	denotes	IL-12
T4530	2315-2323	Positive_regulation	denotes	resulted
T4531	2327-2332	Protein	denotes	IL-10
T4532	2333-2343	Gene_expression	denotes	expression
T4533	2395-2404	Positive_regulation	denotes	dependent	true
T4534	2514-2519	Protein	denotes	TGF-β
T4535	2524-2530	Positive_regulation	denotes	induce		true
T4536	2531-2536	Protein	denotes	IL-10
T4537	2540-2543	Protein	denotes	CD4
T4538	2693-2707	Negative_regulation	denotes	neutralization
T4539	2711-2716	Protein	denotes	TGF-β
T4540	2724-2733	Positive_regulation	denotes	increased
T4541	2734-2739	Protein	denotes	IL-10
T4542	2740-2750	Gene_expression	denotes	production
T4543	2812-2817	Protein	denotes	IL-10
T4544	2818-2827	Gene_expression	denotes	producing
T4545	2843-2851	Positive_regulation	denotes	depended	true
T4546	2843-2851	Positive_regulation	denotes	depended
T4547	2843-2851	Positive_regulation	denotes	depended	true
T4548	2871-2876	Protein	denotes	IL-12
T4549	2950-2954	Protein	denotes	IL-2
T4550	2958-2963	Protein	denotes	TGF-β
R3405	T4450	T4449	themeOf	IL-10,Producing
R3410	T4453	T4452	themeOf	IFN-γ,coproducing
R3415	T4454	T4451	themeOf	IL-10,coproducing
R3418	T4457	T4456	equivalentTo	OVA,ovalbumin
R3423	T4460	T4458	themeOf	expressing,rise
R3429	T4461	T4459	themeOf	expressing,rise
R3431	T4462	T4461	themeOf	IFN-γ,expressing
R3432	T4463	T4460	themeOf	IL-10,expressing
R3433	T4466	T4465	themeOf	IL-4,expressed
R3434	T4467	T4464	themeOf	IL-10,expressed
R3435	T4526	T4528	themeOf	recombination-activating gene 1,deficient
R3436	T4471	T4473	causeOf	IL-12,resulted
R3437	T4527	T4526	equivalentTo	Rag1,recombination-activating gene 1
R3438	T4529	T4530	causeOf	IL-12,resulted
R3439	T4531	T4532	themeOf	IL-10,expression
R3440	T4471	T4472	causeOf	IL-12,resulted
R3441	T4532	T4530	themeOf	expression,resulted
R3442	T4532	T4533	themeOf	expression,dependent
R3443	T4534	T4535	causeOf	TGF-β,induce
R3444	T4474	T4475	themeOf	IFN-γ,producing
R3445	T4536	T4535	themeOf	IL-10,induce
R3446	T4538	T4540	causeOf	neutralization,increased
R3447	T4539	T4538	themeOf	TGF-β,neutralization
R3448	T4541	T4542	themeOf	IL-10,production
R3449	T4475	T4473	themeOf	producing,resulted
R3450	T4542	T4540	themeOf	production,increased
R3451	T4543	T4544	themeOf	IL-10,producing
R3452	T4544	T4546	themeOf	producing,depended
R3453	T4544	T4545	themeOf	producing,depended
R3454	T4544	T4547	themeOf	producing,depended
R3455	T4476	T4472	themeOf	coproduced,resulted
R3456	T4477	T4476	themeOf	IL-10,coproduced
R3457	T4548	T4546	causeOf	IL-12,depended
R3458	T4549	T4545	causeOf	IL-2,depended
R3459	T4479	T4482	themeOf	lack,resulted
R3460	T4550	T4547	causeOf	TGF-β,depended
R3461	T4480	T4479	themeOf	IL-10,lack
R3462	T4480	T4481	themeOf	IL-10,produced
R3463	T4483	T4482	causeOf	inhibition,resulted
R3464	T4484	T4485	themeOf	IL-10,production
R3465	T4485	T4483	themeOf	production,inhibition
R3466	T4489	T4490	causeOf	IL-12,induced
R3468	T4489	T4491	causeOf	IL-12,induced
R3469	T4492	T4493	themeOf	IFN-γ,expression
R3471	T4493	T4490	themeOf	expression,induced
R3472	T4494	T4495	themeOf	IL-10,expression
R3474	T4495	T4491	themeOf	expression,induced
R3476	T4496	T4497	causeOf	IL-12,induce
R3479	T4498	T4499	themeOf	IL-10,production
R3480	T4499	T4497	themeOf	production,induce
R3483	T4501	T4502	themeOf	IL-10,producing
R3486	T4503	T4504	themeOf	produced,more
R3490	T4505	T4503	themeOf	IL-10,produced
R3493	T4506	T4508	themeOf	producing,required
R3497	T4507	T4506	themeOf	IL-10,producing
R3501	T4509	T4508	causeOf	IL-12,required
R3503	T4512	T4510	themeOf	IL-10,produce
R3506	T4513	T4511	themeOf	IFN-γ,produce
R3509	T4515	T4514	themeOf	produce,lost
R3512	T4516	T4515	themeOf	IL-2,produce
R3513	T4519	T4520	themeOf	IL-10,production
R3517	T4521	T4522	themeOf	IL-10,producing
R3519	T4524	T4523	themeOf	IL-2,limited

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T4551	0-5	Protein	denotes	IL-12
T4552	138-143	Protein	denotes	IFN-γ
T4553	148-153	Protein	denotes	IL-10
T4554	205-209	Protein	denotes	CD4+
T4555	268-277	Protein	denotes	ovalbumin
T4556	126-137	Gene_expression	denotes	coproducing
T4557	126-137	Gene_expression	denotes	coproducing
T4558	360-363	Protein	denotes	Th1
T4559	381-386	Protein	denotes	IFN-γ
T4560	370-380	Gene_expression	denotes	expressing
T4561	370-380	Gene_expression	denotes	expressing
T4562	616-620	Protein	denotes	IL-4
T4563	625-630	Protein	denotes	IL-10
T4564	601-610	Gene_expression	denotes	expressed
T4565	601-610	Gene_expression	denotes	expressed
T4566	681-685	Protein	denotes	CD4+
T4567	736-744	Protein	denotes	anti-CD3
T4568	749-769	Protein	denotes	anti-CD28 antibodies
T4569	789-794	Protein	denotes	IL-12
T4570	807-812	Protein	denotes	IFN-γ
T4571	867-872	Protein	denotes	IL-10
T4572	719-730	Positive_regulation	denotes	stimulation
T4573	813-822	Gene_expression	denotes	producing
T4574	856-866	Gene_expression	denotes	coproduced
T4575	971-976	Protein	denotes	IL-10
T4576	1027-1032	Protein	denotes	IL-10
T4577	1124-1128	Protein	denotes	CD4+
T4578	1205-1210	Protein	denotes	IL-12
T4579	963-967	Negative_regulation	denotes	lack
T4580	977-985	Gene_expression	denotes	produced
T4581	999-1007	Positive_regulation	denotes	resulted
T4582	1033-1043	Gene_expression	denotes	production
T4583	963-967	Negative_regulation	denotes	lack
T4584	1013-1023	Negative_regulation	denotes	inhibition
T4585	1294-1299	Protein	denotes	IFN-γ
T4586	1334-1339	Protein	denotes	IL-10
T4587	1422-1427	Protein	denotes	IL-10
T4588	1300-1310	Gene_expression	denotes	expression
T4589	1340-1350	Gene_expression	denotes	expression
T4590	1428-1438	Gene_expression	denotes	production
T4591	1286-1293	Positive_regulation	denotes	induced
T4592	1286-1293	Positive_regulation	denotes	induced
T4593	1403-1409	Positive_regulation	denotes	induce
T4594	1540-1545	Protein	denotes	IL-12
T4595	1630-1643	Protein	denotes	IL-10 protein
T4596	1616-1624	Gene_expression	denotes	produced
T4597	1729-1734	Protein	denotes	IL-10
T4598	1749-1754	Protein	denotes	IL-12
T4599	1719-1728	Gene_expression	denotes	producing
T4600	1735-1743	Positive_regulation	denotes	required
T4601	1835-1840	Protein	denotes	IL-10
T4602	1845-1850	Protein	denotes	IFN-γ
T4603	1810-1817	Gene_expression	denotes	produce
T4604	1810-1817	Gene_expression	denotes	produce
T4605	1928-1933	Protein	denotes	IL-12
T4606	1963-1967	Protein	denotes	CD4+
T4607	2164-2168	Protein	denotes	CD4+
T4608	2215-2221	Protein	denotes	gene 1
T4609	2223-2227	Protein	denotes	Rag1
T4610	2303-2308	Protein	denotes	IL-12
T4611	2327-2332	Protein	denotes	IL-10
T4612	2228-2238	Negative_regulation	denotes	-deficient
T4613	2228-2238	Negative_regulation	denotes	-deficient
T4614	2333-2343	Gene_expression	denotes	expression
T4615	2315-2323	Positive_regulation	denotes	resulted
T4616	2514-2519	Protein	denotes	TGF-β
T4617	2531-2536	Protein	denotes	IL-10
T4618	2540-2544	Protein	denotes	CD4+
T4619	2524-2530	Positive_regulation	denotes	induce
T4620	2711-2716	Protein	denotes	TGF-β
T4621	2734-2739	Protein	denotes	IL-10
T4622	2693-2707	Negative_regulation	denotes	neutralization
T4623	2740-2750	Gene_expression	denotes	production
T4624	2724-2733	Positive_regulation	denotes	increased
T4625	2871-2876	Protein	denotes	IL-12
T4626	2950-2954	Protein	denotes	IL-2
T4627	2958-2963	Protein	denotes	TGF-β
R3467	T4552	T4556	themeOf	IFN-γ,coproducing
R3470	T4553	T4557	themeOf	IL-10,coproducing
R3473	T4558	T4560	themeOf	Th1,expressing
R3475	T4559	T4561	themeOf	IFN-γ,expressing
R3477	T4562	T4564	themeOf	IL-4,expressed
R3478	T4563	T4565	themeOf	IL-10,expressed
R3481	T4568	T4572	themeOf	anti-CD28 antibodies,stimulation
R3482	T4569	T4572	causeOf	IL-12,stimulation
R3484	T4570	T4573	themeOf	IFN-γ,producing
R3485	T4571	T4574	themeOf	IL-10,coproduced
R3487	T4575	T4579	themeOf	IL-10,lack
R3488	T4575	T4580	themeOf	IL-10,produced
R3489	T4576	T4582	themeOf	IL-10,production
R3491	T4579	T4581	themeOf	lack,resulted
R3492	T4580	T4583	themeOf	produced,lack
R3494	T4582	T4584	themeOf	production,inhibition
R3495	T4585	T4588	themeOf	IFN-γ,expression
R3496	T4586	T4589	themeOf	IL-10,expression
R3498	T4587	T4590	themeOf	IL-10,production
R3499	T4588	T4591	themeOf	expression,induced
R3500	T4589	T4592	themeOf	expression,induced
R3502	T4590	T4593	themeOf	production,induce
R3504	T4595	T4596	themeOf	IL-10 protein,produced
R3505	T4597	T4599	themeOf	IL-10,producing
R3507	T4598	T4600	causeOf	IL-12,required
R3508	T4599	T4600	themeOf	producing,required
R3510	T4601	T4603	themeOf	IL-10,produce
R3511	T4602	T4604	themeOf	IFN-γ,produce
R3514	T4608	T4612	themeOf	gene 1,-deficient
R3515	T4609	T4613	themeOf	Rag1,-deficient
R3516	T4611	T4614	themeOf	IL-10,expression
R3518	T4614	T4615	themeOf	expression,resulted
R3520	T4616	T4619	causeOf	TGF-β,induce
R3521	T4617	T4619	themeOf	IL-10,induce
R3522	T4623	T4624	themeOf	production,increased
R3523	T4620	T4622	themeOf	TGF-β,neutralization
R3524	T4621	T4623	themeOf	IL-10,production

test2

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T2765	0-5	Protein	denotes	IL-12
T2766	68-77	Gene_expression	denotes	Producing
T2767	126-137	Gene_expression	denotes	coproducing
T2768	138-143	Protein	denotes	IFN-γ
T2769	148-153	Protein	denotes	IL-10
T2770	205-208	Protein	denotes	CD4
T2771	268-277	Protein	denotes	ovalbumin	true
T2772	295-298	Protein	denotes	OVA
T2773	370-380	Gene_expression	denotes	expressing
T2774	381-386	Protein	denotes	IFN-γ
T2775	460-465	Protein	denotes	IL-10
T2776	601-610	Gene_expression	denotes	expressed
T2777	616-620	Protein	denotes	IL-4
T2778	625-630	Protein	denotes	IL-10
T2779	681-684	Protein	denotes	CD4
T2780	741-744	Protein	denotes	CD3		true
T2781	754-758	Protein	denotes	CD28
T2782	789-794	Protein	denotes	IL-12
T2783	795-803	Positive_regulation	denotes	resulted
T2784	807-812	Protein	denotes	IFN-γ
T2785	813-822	Gene_expression	denotes	producing
T2786	856-866	Gene_expression	denotes	coproduced
T2787	867-872	Protein	denotes	IL-10	true	true
T2788	891-900	Positive_regulation	denotes	resulting
T2789	917-921	Protein	denotes	IL-4
T2790	963-967	Negative_regulation	denotes	lack
T2791	971-976	Protein	denotes	IL-10
T2792	977-985	Gene_expression	denotes	produced
T2793	999-1007	Positive_regulation	denotes	resulted
T2794	1013-1023	Negative_regulation	denotes	inhibition
T2795	1027-1032	Protein	denotes	IL-10
T2796	1033-1043	Gene_expression	denotes	production
T2797	1090-1098	Positive_regulation	denotes	required
T2798	1099-1104	Protein	denotes	IL-12
T2799	1124-1127	Protein	denotes	CD4
T2800	1205-1210	Protein	denotes	IL-12
T2801	1237-1242	Protein	denotes	IL-12
T2802	1286-1293	Positive_regulation	denotes	induced
T2803	1294-1299	Protein	denotes	IFN-γ
T2804	1300-1310	Gene_expression	denotes	expression	true
T2805	1334-1339	Protein	denotes	IL-10		true
T2806	1340-1350	Gene_expression	denotes	expression
T2807	1368-1373	Protein	denotes	IL-12
T2808	1403-1409	Positive_regulation	denotes	induce
T2809	1422-1427	Protein	denotes	IL-10
T2810	1428-1438	Gene_expression	denotes	production
T2811	1540-1545	Protein	denotes	IL-12	true
T2812	1578-1583	Protein	denotes	IL-10	true
T2813	1584-1593	Gene_expression	denotes	producing
T2814	1616-1624	Gene_expression	denotes	produced
T2815	1630-1635	Protein	denotes	IL-10
T2816	1719-1728	Gene_expression	denotes	producing
T2817	1729-1734	Protein	denotes	IL-10
T2818	1735-1743	Positive_regulation	denotes	required
T2819	1749-1754	Protein	denotes	IL-12
T2820	1810-1817	Gene_expression	denotes	produce
T2821	1835-1840	Protein	denotes	IL-10
T2822	1845-1850	Protein	denotes	IFN-γ
T2823	1855-1859	Negative_regulation	denotes	lost
T2824	1878-1885	Gene_expression	denotes	produce
T2825	1886-1890	Protein	denotes	IL-2
T2826	1928-1933	Protein	denotes	IL-12
T2827	1963-1966	Protein	denotes	CD4
T2828	2050-2055	Protein	denotes	IL-10
T2829	2056-2066	Gene_expression	denotes	production
T2830	2087-2091	Positive_regulation	denotes	high
T2831	2092-2097	Protein	denotes	IL-10
T2832	2098-2107	Gene_expression	denotes	producing
T2833	2144-2151	Negative_regulation	denotes	limited
T2834	2152-2156	Protein	denotes	IL-2
T2835	2164-2167	Protein	denotes	CD4
T2836	2190-2221	Protein	denotes	recombination-activating gene 1
T2837	2223-2227	Protein	denotes	Rag1
T2838	2229-2238	Negative_regulation	denotes	deficient
T2839	2303-2308	Protein	denotes	IL-12
T2840	2315-2323	Positive_regulation	denotes	resulted
T2841	2327-2332	Protein	denotes	IL-10
T2842	2333-2343	Gene_expression	denotes	expression
T2843	2376-2386	Gene_expression	denotes	expression
T2844	2395-2404	Regulation	denotes	dependent
T2845	2514-2519	Protein	denotes	TGF-β
T2846	2524-2530	Positive_regulation	denotes	induce
T2847	2531-2536	Protein	denotes	IL-10
T2848	2540-2543	Protein	denotes	CD4
T2849	2693-2707	Negative_regulation	denotes	neutralization
T2850	2711-2716	Protein	denotes	TGF-β
T2851	2717-2720	Positive_regulation	denotes	led
T2852	2724-2733	Positive_regulation	denotes	increased
T2853	2734-2739	Protein	denotes	IL-10
T2854	2740-2750	Gene_expression	denotes	production
T2855	2812-2817	Protein	denotes	IL-10
T2856	2818-2827	Gene_expression	denotes	producing
T2857	2871-2876	Protein	denotes	IL-12
T2858	2950-2954	Protein	denotes	IL-2
T2859	2958-2963	Protein	denotes	TGF-β
R2081	T2768	T2767	themeOf	IFN-γ,coproducing
R2082	T2769	T2767	themeOf	IL-10,coproducing
R2083	T2772	T2771	equivalentTo	OVA,ovalbumin
R2084	T2774	T2773	themeOf	IFN-γ,expressing
R2085	T2775	T2773	themeOf	IL-10,expressing
R2086	T2777	T2776	themeOf	IL-4,expressed
R2087	T2778	T2776	themeOf	IL-10,expressed
R2088	T2782	T2783	causeOf	IL-12,resulted
R2089	T2784	T2785	themeOf	IFN-γ,producing
R2090	T2785	T2783	themeOf	producing,resulted
R2091	T2786	T2783	themeOf	coproduced,resulted
R2092	T2787	T2786	themeOf	IL-10,coproduced
R2093	T2789	T2788	causeOf	IL-4,resulting
R2094	T2790	T2793	causeOf	lack,resulted
R2095	T2791	T2792	themeOf	IL-10,produced
R2096	T2792	T2790	themeOf	produced,lack
R2097	T2795	T2796	themeOf	IL-10,production
R2098	T2796	T2794	themeOf	production,inhibition
R2099	T2798	T2797	themeOf	IL-12,required
R2100	T2801	T2802	causeOf	IL-12,induced
R2101	T2803	T2804	themeOf	IFN-γ,expression
R2102	T2804	T2802	themeOf	expression,induced
R2103	T2805	T2806	themeOf	IL-10,expression
R2104	T2806	T2802	themeOf	expression,induced
R2105	T2807	T2808	causeOf	IL-12,induce
R2106	T2809	T2810	themeOf	IL-10,production
R2107	T2810	T2808	themeOf	production,induce
R2108	T2812	T2813	themeOf	IL-10,producing
R2109	T2815	T2814	themeOf	IL-10,produced
R2110	T2816	T2818	themeOf	producing,required
R2111	T2817	T2816	themeOf	IL-10,producing
R2112	T2819	T2818	causeOf	IL-12,required
R2113	T2821	T2820	themeOf	IL-10,produce
R2114	T2822	T2820	themeOf	IFN-γ,produce
R2115	T2824	T2823	themeOf	produce,lost
R2116	T2825	T2824	themeOf	IL-2,produce
R2117	T2828	T2829	themeOf	IL-10,production
R2118	T2831	T2832	themeOf	IL-10,producing
R2119	T2832	T2830	themeOf	producing,high
R2120	T2834	T2833	themeOf	IL-2,limited
R2121	T2836	T2838	themeOf	recombination-activating gene 1,deficient
R2122	T2837	T2836	equivalentTo	Rag1,recombination-activating gene 1
R2123	T2841	T2842	themeOf	IL-10,expression
R2124	T2842	T2840	themeOf	expression,resulted
R2125	T2842	T2844	themeOf	expression,dependent
R2126	T2843	T2844	themeOf	expression,dependent
R2127	T2845	T2846	causeOf	TGF-β,induce
R2128	T2847	T2846	themeOf	IL-10,induce
R2129	T2849	T2852	causeOf	neutralization,increased
R2130	T2849	T2851	causeOf	neutralization,led
R2131	T2850	T2849	themeOf	TGF-β,neutralization
R2132	T2852	T2851	themeOf	increased,led
R2133	T2853	T2854	themeOf	IL-10,production
R2134	T2854	T2852	themeOf	production,increased
R2135	T2855	T2856	themeOf	IL-10,producing

PMC:2791889 / 5900-8905 JSONTXT

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