PMC:2791889 / 4348-4770
Annnotations
bionlp-st-ge-2016-uniprot
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1171 | 101-133 | P28482 | denotes | mitogen-activated protein kinase |
| T1172 | 101-133 | P27361 | denotes | mitogen-activated protein kinase |
| T1173 | 188-193 | P01579 | denotes | IFN-γ |
| T1174 | 201-206 | P29459 | denotes | IL-12 |
| T1175 | 201-206 | P29460 | denotes | IL-12 |
| T1176 | 267-271 | P27361 | denotes | ERK1 |
| T1177 | 276-280 | P28482 | denotes | ERK2 |
| T1178 | 317-321 | P05112 | denotes | IL-4 |
bionlp-st-ge-2016-reference
| Id | Subject | Object | Predicate | Lexical cue | Negation |
|---|---|---|---|---|---|
| T1078 | 158-164 | Positive_regulation | denotes | result | |
| T1079 | 178-187 | Gene_expression | denotes | producing | |
| T1080 | 188-193 | Protein | denotes | IFN-γ | |
| T1081 | 201-206 | Protein | denotes | IL-12 | |
| T1082 | 207-218 | Regulation | denotes | independent | true |
| T1083 | 267-271 | Protein | denotes | ERK1 | |
| T1084 | 276-280 | Protein | denotes | ERK2 | |
| T1085 | 281-291 | Positive_regulation | denotes | activation | |
| T1086 | 281-291 | Positive_regulation | denotes | activation | |
| T1087 | 293-298 | Positive_regulation | denotes | favor | |
| T1088 | 293-298 | Positive_regulation | denotes | favor | |
| T1089 | 317-321 | Protein | denotes | IL-4 | |
| T1090 | 322-331 | Localization | denotes | secretion | |
| R785 | T1079 | T1078 | themeOf | producing,result | |
| R786 | T1079 | T1082 | themeOf | producing,independent | |
| R787 | T1080 | T1079 | themeOf | IFN-γ,producing | |
| R788 | T1081 | T1082 | causeOf | IL-12,independent | |
| R789 | T1083 | T1086 | themeOf | ERK1,activation | |
| R790 | T1084 | T1085 | themeOf | ERK2,activation | |
| R791 | T1085 | T1088 | causeOf | activation,favor | |
| R792 | T1086 | T1087 | causeOf | activation,favor | |
| R793 | T1089 | T1090 | themeOf | IL-4,secretion | |
| R794 | T1090 | T1087 | themeOf | secretion,favor | |
| R795 | T1090 | T1088 | themeOf | secretion,favor |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 19646904-7595230-46582682 | 416-420 | 7595230 | denotes | 2005 |
| 19646904-7595228-46582682 | 416-420 | 7595228 | denotes | 2005 |
| 19646904-12594266-46582682 | 416-420 | 12594266 | denotes | 2005 |
| 19646904-16172258-46582682 | 416-420 | 16172258 | denotes | 2005 |
| T93907 | 416-420 | 7595230 | denotes | 2005 |
| T87974 | 416-420 | 7595228 | denotes | 2005 |
| T12507 | 416-420 | 12594266 | denotes | 2005 |
| T81044 | 416-420 | 16172258 | denotes | 2005 |
bionlp-st-ge-2016-spacy-parsed
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1844 | 0-7 | IN | denotes | Whereas |
| T1845 | 8-12 | JJ | denotes | high |
| T1846 | 13-18 | NNS | denotes | doses |
| T1847 | 19-21 | IN | denotes | of |
| T1848 | 22-29 | NN | denotes | antigen |
| T1849 | 29-30 | , | denotes | , |
| T1850 | 31-35 | IN | denotes | with |
| T1851 | 36-45 | VBN | denotes | sustained |
| T1852 | 46-49 | NNP | denotes | TCR |
| T1853 | 50-59 | VBG | denotes | signaling |
| T1854 | 60-63 | CC | denotes | and |
| T1855 | 64-84 | JJ | denotes | extracellular-signal |
| T1856 | 85-94 | VBN | denotes | regulated |
| T1857 | 95-96 | -LRB- | denotes | ( |
| T1858 | 96-99 | NNP | denotes | ERK |
| T1859 | 99-100 | -RRB- | denotes | ) |
| T1860 | 101-118 | JJ | denotes | mitogen-activated |
| T1861 | 119-126 | NN | denotes | protein |
| T1862 | 127-133 | NN | denotes | kinase |
| T1863 | 134-135 | -LRB- | denotes | ( |
| T1864 | 135-139 | NNP | denotes | MAPK |
| T1865 | 139-140 | -RRB- | denotes | ) |
| T1866 | 141-156 | NN | denotes | phosphorylation |
| T1867 | 156-157 | , | denotes | , |
| T1868 | 158-164 | NN | denotes | result |
| T1869 | 165-167 | IN | denotes | in |
| T1870 | 168-171 | JJ | denotes | Th1 |
| T1871 | 172-177 | NNS | denotes | cells |
| T1872 | 178-187 | VBG | denotes | producing |
| T1873 | 188-193 | JJ | denotes | IFN-γ |
| T1874 | 194-197 | IN | denotes | via |
| T1875 | 198-200 | DT | denotes | an |
| T1876 | 201-218 | JJ | denotes | IL-12-independent |
| T1877 | 219-228 | NN | denotes | mechanism |
| T1878 | 228-229 | , | denotes | , |
| T1879 | 230-233 | JJ | denotes | low |
| T1880 | 234-239 | NNS | denotes | doses |
| T1881 | 240-242 | IN | denotes | of |
| T1882 | 243-250 | NN | denotes | antigen |
| T1883 | 250-251 | , | denotes | , |
| T1884 | 252-256 | IN | denotes | with |
| T1885 | 257-266 | NN | denotes | transient |
| T1886 | 267-271 | CD | denotes | ERK1 |
| T1887 | 272-275 | CC | denotes | and |
| T1888 | 276-280 | CD | denotes | ERK2 |
| T1889 | 281-291 | NN | denotes | activation |
| T1890 | 291-292 | , | denotes | , |
| T1891 | 293-298 | VBP | denotes | favor |
| T1892 | 299-302 | JJ | denotes | Th2 |
| T1893 | 303-312 | NNS | denotes | responses |
| T1894 | 313-316 | CC | denotes | and |
| T1895 | 317-321 | NN | denotes | IL-4 |
| T1896 | 322-331 | NN | denotes | secretion |
| T1897 | 332-333 | -LRB- | denotes | ( |
| T1898 | 333-341 | JJ | denotes | Constant |
| T1899 | 342-344 | FW | denotes | et |
| T1900 | 345-348 | FW | denotes | al. |
| T1901 | 348-349 | , | denotes | , |
| T1902 | 350-354 | CD | denotes | 1995 |
| T1903 | 354-355 | : | denotes | ; |
| T1904 | 356-362 | NNP | denotes | Hosken |
| T1905 | 363-365 | FW | denotes | et |
| T1906 | 366-369 | FW | denotes | al. |
| T1907 | 369-370 | , | denotes | , |
| T1908 | 371-375 | CD | denotes | 1995 |
| T1909 | 375-376 | : | denotes | ; |
| T1910 | 377-386 | NNP | denotes | Jorritsma |
| T1911 | 387-389 | FW | denotes | et |
| T1912 | 390-393 | FW | denotes | al. |
| T1913 | 393-394 | , | denotes | , |
| T1914 | 395-399 | CD | denotes | 2003 |
| T1915 | 399-400 | : | denotes | ; |
| T1916 | 401-407 | NNP | denotes | Yamane |
| T1917 | 408-410 | FW | denotes | et |
| T1918 | 411-414 | FW | denotes | al. |
| T1919 | 414-415 | , | denotes | , |
| T1920 | 416-420 | CD | denotes | 2005 |
| T1921 | 420-421 | -RRB- | denotes | ) |
| T1922 | 421-422 | . | denotes | . |
| R1446 | T1844 | T1868 | mark | Whereas,result |
| R1447 | T1845 | T1846 | amod | high,doses |
| R1448 | T1846 | T1868 | nsubj | doses,result |
| R1450 | T1847 | T1846 | prep | of,doses |
| R1451 | T1848 | T1847 | pobj | antigen,of |
| R1453 | T1849 | T1868 | punct | ",",result |
| R1454 | T1850 | T1868 | prep | with,result |
| R1455 | T1851 | T1853 | amod | sustained,signaling |
| R1457 | T1852 | T1853 | compound | TCR,signaling |
| R1458 | T1853 | T1850 | pobj | signaling,with |
| R1460 | T1854 | T1853 | cc | and,signaling |
| R1461 | T1855 | T1853 | conj | extracellular-signal,signaling |
| R1465 | T1856 | T1855 | acl | regulated,extracellular-signal |
| R1467 | T1857 | T1855 | punct | (,extracellular-signal |
| R1469 | T1858 | T1855 | appos | ERK,extracellular-signal |
| R1471 | T1859 | T1855 | punct | ),extracellular-signal |
| R1472 | T1860 | T1861 | amod | mitogen-activated,protein |
| R1474 | T1861 | T1868 | nsubj | protein,result |
| R1475 | T1862 | T1861 | amod | kinase,protein |
| R1476 | T1863 | T1864 | punct | (,MAPK |
| R1478 | T1864 | T1862 | appos | MAPK,kinase |
| R1479 | T1865 | T1864 | punct | ),MAPK |
| R1480 | T1866 | T1862 | conj | phosphorylation,kinase |
| R1482 | T1867 | T1866 | punct | ",",phosphorylation |
| R1483 | T1868 | T1891 | advcl | result,favor |
| R1484 | T1869 | T1868 | prep | in,result |
| R1485 | T1870 | T1871 | amod | Th1,cells |
| R1486 | T1871 | T1869 | pobj | cells,in |
| R1487 | T1872 | T1871 | acl | producing,cells |
| R1489 | T1873 | T1872 | dobj | IFN-γ,producing |
| R1490 | T1874 | T1868 | prep | via,result |
| R1491 | T1875 | T1877 | det | an,mechanism |
| R1493 | T1876 | T1877 | compound | IL-12-independent,mechanism |
| R1494 | T1877 | T1874 | pobj | mechanism,via |
| R1495 | T1878 | T1877 | punct | ",",mechanism |
| R1496 | T1879 | T1880 | amod | low,doses |
| R1498 | T1880 | T1877 | conj | doses,mechanism |
| R1499 | T1881 | T1880 | prep | of,doses |
| R1500 | T1882 | T1881 | pobj | antigen,of |
| R1502 | T1883 | T1868 | punct | ",",result |
| R1503 | T1884 | T1868 | prep | with,result |
| R1504 | T1885 | T1891 | nmod | transient,favor |
| R1506 | T1886 | T1885 | nummod | ERK1,transient |
| R1507 | T1887 | T1885 | cc | and,transient |
| R1508 | T1888 | T1889 | nummod | ERK2,activation |
| R1509 | T1922 | T1918 | punct | .,al. |
| R1510 | T1889 | T1885 | conj | activation,transient |
| R1511 | T1890 | T1891 | punct | ",",favor |
| R1512 | T1891 | T1918 | ccomp | favor,al. |
| R1514 | T1892 | T1893 | amod | Th2,responses |
| R1515 | T1893 | T1891 | dobj | responses,favor |
| R1518 | T1894 | T1893 | cc | and,responses |
| R1519 | T1895 | T1896 | compound | IL-4,secretion |
| R1521 | T1896 | T1893 | conj | secretion,responses |
| R1522 | T1897 | T1912 | punct | (,al. |
| R1525 | T1898 | T1900 | amod | Constant,al. |
| R1528 | T1899 | T1900 | nmod | et,al. |
| R1529 | T1900 | T1912 | ccomp | al.,al. |
| R1530 | T1901 | T1900 | punct | ",",al. |
| R1531 | T1902 | T1900 | npadvmod | 1995,al. |
| R1532 | T1903 | T1912 | punct | ;,al. |
| R1533 | T1904 | T1906 | compound | Hosken,al. |
| R1534 | T1905 | T1906 | compound | et,al. |
| R1536 | T1906 | T1912 | ccomp | al.,al. |
| R1537 | T1907 | T1906 | punct | ",",al. |
| R1538 | T1908 | T1906 | npadvmod | 1995,al. |
| R1540 | T1909 | T1912 | punct | ;,al. |
| R1541 | T1910 | T1912 | compound | Jorritsma,al. |
| R1542 | T1911 | T1912 | compound | et,al. |
| R1543 | T1912 | T1896 | parataxis | al.,secretion |
| R1545 | T1913 | T1912 | punct | ",",al. |
| R1546 | T1914 | T1912 | npadvmod | 2003,al. |
| R1547 | T1915 | T1918 | punct | ;,al. |
| R1549 | T1916 | T1918 | compound | Yamane,al. |
| R1550 | T1917 | T1918 | compound | et,al. |
| R1551 | T1918 | T1918 | ROOT | al.,al. |
| R1553 | T1919 | T1918 | punct | ",",al. |
| R1554 | T1920 | T1918 | npadvmod | 2005,al. |
| R1555 | T1921 | T1918 | punct | ),al. |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2137 | 46-49 | http://purl.obolibrary.org/obo/GO_0006283 | denotes | TCR |
| T2173 | 96-99 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK |
| T2174 | 135-139 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T2175 | 267-271 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK1 |
| T2177 | 276-280 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK2 |
| T2180 | 109-133 | http://purl.obolibrary.org/obo/GO_0034199 | denotes | activated protein kinase |
| T2181 | 109-133 | http://purl.obolibrary.org/obo/GO_0032147 | denotes | activated protein kinase |
| T2182 | 109-133 | http://purl.obolibrary.org/obo/GO_0030295 | denotes | activated protein kinase |
| T2183 | 109-133 | http://purl.obolibrary.org/obo/GO_0032111 | denotes | activated protein kinase |
| T2184 | 141-156 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T2186 | 267-291 | http://purl.obolibrary.org/obo/GO_0070374 | denotes | ERK1 and ERK2 activation |
| T2187 | 303-321 | http://purl.obolibrary.org/obo/GO_0071353 | denotes | responses and IL-4 |
| T2188 | 303-321 | http://purl.obolibrary.org/obo/GO_0070670 | denotes | responses and IL-4 |
| T2189 | 317-331 | http://purl.obolibrary.org/obo/GO_0072602 | denotes | IL-4 secretion |
| T2190 | 322-331 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T2157 | 50-59 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2206 | 201-206 | http://purl.obolibrary.org/obo/GO_0005143 | denotes | IL-12 |
| T2211 | 317-321 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
| T2217 | 96-99 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK |
| T2218 | 135-139 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T2219 | 267-271 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK1 |
| T2221 | 276-280 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK2 |
| T2224 | 109-133 | http://purl.obolibrary.org/obo/GO_0030295 | denotes | activated protein kinase |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2242 | 46-49 | http://purl.obolibrary.org/obo/GO_0042101 | denotes | TCR |
| T2246 | 64-77 | http://purl.obolibrary.org/obo/GO_0005576 | denotes | extracellular |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1128 | 0-422 | Sentence | denotes | Whereas high doses of antigen, with sustained TCR signaling and extracellular-signal regulated (ERK) mitogen-activated protein kinase (MAPK) phosphorylation, result in Th1 cells producing IFN-γ via an IL-12-independent mechanism, low doses of antigen, with transient ERK1 and ERK2 activation, favor Th2 responses and IL-4 secretion (Constant et al., 1995; Hosken et al., 1995; Jorritsma et al., 2003; Yamane et al., 2005). |
| T24 | 0-422 | Sentence | denotes | Whereas high doses of antigen, with sustained TCR signaling and extracellular-signal regulated (ERK) mitogen-activated protein kinase (MAPK) phosphorylation, result in Th1 cells producing IFN-γ via an IL-12-independent mechanism, low doses of antigen, with transient ERK1 and ERK2 activation, favor Th2 responses and IL-4 secretion (Constant et al., 1995; Hosken et al., 1995; Jorritsma et al., 2003; Yamane et al., 2005). |
events-check-again
| Id | Subject | Object | Predicate | Lexical cue | Negation |
|---|---|---|---|---|---|
| T2515 | 158-164 | Positive_regulation | denotes | result | |
| T2516 | 178-187 | Gene_expression | denotes | producing | |
| T2517 | 188-193 | Protein | denotes | IFN-γ | |
| T2518 | 201-206 | Protein | denotes | IL-12 | |
| T2519 | 207-218 | Regulation | denotes | independent | true |
| T2520 | 267-271 | Protein | denotes | ERK1 | |
| T2521 | 276-280 | Protein | denotes | ERK2 | |
| T2522 | 281-291 | Positive_regulation | denotes | activation | |
| T2523 | 281-291 | Positive_regulation | denotes | activation | |
| T2524 | 293-298 | Positive_regulation | denotes | favor | |
| T2525 | 293-298 | Positive_regulation | denotes | favor | |
| T2526 | 317-321 | Protein | denotes | IL-4 | |
| T2527 | 322-331 | Localization | denotes | secretion | |
| R1925 | T2516 | T2515 | themeOf | producing,result | |
| R1926 | T2516 | T2519 | themeOf | producing,independent | |
| R1927 | T2517 | T2516 | themeOf | IFN-γ,producing | |
| R1928 | T2518 | T2519 | causeOf | IL-12,independent | |
| R1929 | T2520 | T2523 | themeOf | ERK1,activation | |
| R1930 | T2521 | T2522 | themeOf | ERK2,activation | |
| R1932 | T2522 | T2525 | causeOf | activation,favor | |
| R1933 | T2523 | T2524 | causeOf | activation,favor | |
| R1936 | T2526 | T2527 | themeOf | IL-4,secretion | |
| R1938 | T2527 | T2524 | themeOf | secretion,favor | |
| R1939 | T2527 | T2525 | themeOf | secretion,favor |
bionlp-st-ge-2016-reference-tees
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2602 | 46-49 | Protein | denotes | TCR |
| T2603 | 96-99 | Protein | denotes | ERK |
| T2604 | 101-133 | Protein | denotes | mitogen-activated protein kinase |
| T2605 | 135-139 | Protein | denotes | MAPK |
| T2606 | 188-193 | Protein | denotes | IFN-γ |
| T2607 | 267-271 | Protein | denotes | ERK1 |
| T2608 | 276-280 | Protein | denotes | ERK2 |
| T2609 | 317-321 | Protein | denotes | IL-4 |
| T2610 | 85-94 | Regulation | denotes | regulated |
| T2611 | 85-94 | Regulation | denotes | regulated |
| T2612 | 85-94 | Regulation | denotes | regulated |
| T2613 | 141-156 | Phosphorylation | denotes | phosphorylation |
| T2614 | 141-156 | Phosphorylation | denotes | phosphorylation |
| T2615 | 141-156 | Phosphorylation | denotes | phosphorylation |
| T2616 | 141-156 | Phosphorylation | denotes | phosphorylation |
| T2617 | 158-164 | Positive_regulation | denotes | result |
| T2618 | 158-164 | Positive_regulation | denotes | result |
| T2619 | 158-164 | Positive_regulation | denotes | result |
| T2620 | 158-164 | Positive_regulation | denotes | result |
| T2621 | 178-187 | Gene_expression | denotes | producing |
| T2622 | 178-187 | Gene_expression | denotes | producing |
| T2623 | 281-291 | Positive_regulation | denotes | activation |
| T2624 | 281-291 | Positive_regulation | denotes | activation |
| T2625 | 281-291 | Positive_regulation | denotes | activation |
| T2626 | 322-331 | Localization | denotes | secretion |
| T2627 | 85-94 | Regulation | denotes | regulated |
| T2628 | 85-94 | Regulation | denotes | regulated |
| T2629 | 85-94 | Regulation | denotes | regulated |
| T2630 | 85-94 | Regulation | denotes | regulated |
| T2631 | 158-164 | Positive_regulation | denotes | result |
| T2632 | 158-164 | Positive_regulation | denotes | result |
| R1968 | T2602 | T2613 | themeOf | TCR,phosphorylation |
| R1970 | T2603 | T2610 | themeOf | ERK,regulated |
| R1971 | T2603 | T2614 | themeOf | ERK,phosphorylation |
| R1972 | T2604 | T2611 | themeOf | mitogen-activated protein kinase,regulated |
| R1973 | T2604 | T2615 | themeOf | mitogen-activated protein kinase,phosphorylation |
| R1974 | T2605 | T2612 | themeOf | MAPK,regulated |
| R1975 | T2605 | T2616 | themeOf | MAPK,phosphorylation |
| R1977 | T2606 | T2621 | themeOf | IFN-γ,producing |
| R1979 | T2607 | T2622 | themeOf | ERK1,producing |
| R1980 | T2608 | T2623 | themeOf | ERK2,activation |
| R1982 | T2609 | T2626 | themeOf | IL-4,secretion |
| R1983 | T2613 | T2617 | themeOf | phosphorylation,result |
| R1984 | T2613 | T2627 | themeOf | phosphorylation,regulated |
| R1985 | T2614 | T2618 | themeOf | phosphorylation,result |
| R1986 | T2614 | T2628 | themeOf | phosphorylation,regulated |
| R1987 | T2615 | T2619 | themeOf | phosphorylation,result |
| R1988 | T2615 | T2629 | themeOf | phosphorylation,regulated |
| R1989 | T2616 | T2620 | themeOf | phosphorylation,result |
| R1990 | T2616 | T2630 | themeOf | phosphorylation,regulated |
| R1991 | T2621 | T2624 | themeOf | producing,activation |
| R1992 | T2621 | T2631 | themeOf | producing,result |
| R1993 | T2622 | T2625 | themeOf | producing,activation |
| R1994 | T2622 | T2632 | themeOf | producing,result |
test2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T977 | 178-187 | Gene_expression | denotes | producing |
| T978 | 188-193 | Protein | denotes | IFN-γ |
| T979 | 201-206 | Protein | denotes | IL-12 |
| T980 | 267-271 | Protein | denotes | ERK1 |
| T981 | 276-280 | Protein | denotes | ERK2 |
| T982 | 281-291 | Positive_regulation | denotes | activation |
| T983 | 317-321 | Protein | denotes | IL-4 |
| T984 | 322-331 | Gene_expression | denotes | secretion |
| R720 | T978 | T977 | themeOf | IFN-γ,producing |
| R721 | T980 | T982 | themeOf | ERK1,activation |
| R722 | T980 | T984 | themeOf | ERK1,secretion |
| R723 | T981 | T982 | themeOf | ERK2,activation |
| R724 | T983 | T984 | themeOf | IL-4,secretion |