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address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352)."}

{"project":"GO-BP","denotations":[{"id":"T11412","span":{"begin":19,"end":35},"obj":"http://purl.obolibrary.org/obo/GO_0032653"},{"id":"T11416","span":{"begin":19,"end":35},"obj":"http://purl.obolibrary.org/obo/GO_0032613"},{"id":"T11420","span":{"begin":80,"end":84},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T11423","span":{"begin":89,"end":93},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T11427","span":{"begin":80,"end":104},"obj":"http://purl.obolibrary.org/obo/GO_0070374"},{"id":"T11429","span":{"begin":109,"end":135},"obj":"http://purl.obolibrary.org/obo/GO_0030154"}],"text":"To address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352)."}

{"project":"GO-MF","denotations":[{"id":"T11436","span":{"begin":19,"end":24},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T11442","span":{"begin":80,"end":84},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T11445","span":{"begin":89,"end":93},"obj":"http://purl.obolibrary.org/obo/GO_0004707"}],"text":"To address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352)."}

{"project":"GO-CC","denotations":[{"id":"T11450","span":{"begin":52,"end":57},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T11451","span":{"begin":130,"end":135},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"To address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352)."}

{"project":"sentences","denotations":[{"id":"T11023","span":{"begin":0,"end":318},"obj":"Sentence"},{"id":"T94","span":{"begin":0,"end":318},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352)."}

{"project":"events-check-again","denotations":[{"id":"T11560","span":{"begin":19,"end":24},"obj":"Protein"},{"id":"T11561","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T11562","span":{"begin":67,"end":76},"obj":"Positive_regulation"},{"id":"T11563","span":{"begin":67,"end":76},"obj":"Positive_regulation"},{"id":"T11564","span":{"begin":80,"end":84},"obj":"Protein"},{"id":"T11565","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T11566","span":{"begin":94,"end":104},"obj":"Positive_regulation"},{"id":"T11567","span":{"begin":94,"end":104},"obj":"Positive_regulation"},{"id":"T11568","span":{"begin":146,"end":149},"obj":"Protein"},{"id":"T11569","span":{"begin":159,"end":163},"obj":"Protein"},{"id":"T11570","span":{"begin":293,"end":296},"obj":"Protein"},{"id":"T11571","span":{"begin":297,"end":306},"obj":"Negative_regulation"}],"relations":[{"id":"R8931","pred":"themeOf","subj":"T11560","obj":"T11561"},{"id":"R8932","pred":"themeOf","subj":"T11561","obj":"T11562"},{"id":"R8933","pred":"themeOf","subj":"T11561","obj":"T11563"},{"id":"R8934","pred":"themeOf","subj":"T11564","obj":"T11566"},{"id":"R8935","pred":"themeOf","subj":"T11565","obj":"T11567"},{"id":"R8936","pred":"causeOf","subj":"T11566","obj":"T11563"},{"id":"R8937","pred":"causeOf","subj":"T11567","obj":"T11562"},{"id":"R8938","pred":"themeOf","subj":"T11570","obj":"T11571"}],"attributes":[{"id":"M219","pred":"Speculation","subj":"T11562","obj":"true"},{"id":"M220","pred":"Speculation","subj":"T11563","obj":"true"}],"text":"To address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352)."}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T11607","span":{"begin":80,"end":84},"obj":"Protein"},{"id":"T11608","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T11609","span":{"begin":141,"end":149},"obj":"Protein"},{"id":"T11610","span":{"begin":154,"end":163},"obj":"Protein"},{"id":"T11611","span":{"begin":293,"end":296},"obj":"Protein"},{"id":"T11612","span":{"begin":94,"end":104},"obj":"Positive_regulation"},{"id":"T11613","span":{"begin":94,"end":104},"obj":"Positive_regulation"},{"id":"T11614","span":{"begin":297,"end":306},"obj":"Negative_regulation"}],"relations":[{"id":"R8965","pred":"themeOf","subj":"T11607","obj":"T11612"},{"id":"R8966","pred":"themeOf","subj":"T11608","obj":"T11613"},{"id":"R8967","pred":"themeOf","subj":"T11611","obj":"T11614"}],"text":"To address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352)."}

{"project":"test2","denotations":[{"id":"T10939","span":{"begin":19,"end":24},"obj":"Protein"},{"id":"T10940","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T10941","span":{"begin":67,"end":76},"obj":"Positive_regulation"},{"id":"T10942","span":{"begin":80,"end":84},"obj":"Protein"},{"id":"T10943","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T10944","span":{"begin":94,"end":104},"obj":"Positive_regulation"},{"id":"T10945","span":{"begin":146,"end":149},"obj":"Protein"},{"id":"T10946","span":{"begin":159,"end":163},"obj":"Protein"},{"id":"T10947","span":{"begin":293,"end":296},"obj":"Protein"},{"id":"T10948","span":{"begin":297,"end":306},"obj":"Negative_regulation"}],"relations":[{"id":"R8425","pred":"themeOf","subj":"T10939","obj":"T10940"},{"id":"R8426","pred":"themeOf","subj":"T10940","obj":"T10941"},{"id":"R8427","pred":"themeOf","subj":"T10942","obj":"T10944"},{"id":"R8428","pred":"themeOf","subj":"T10943","obj":"T10944"},{"id":"R8429","pred":"causeOf","subj":"T10944","obj":"T10941"},{"id":"R8430","pred":"themeOf","subj":"T10947","obj":"T10948"}],"attributes":[{"id":"M204","pred":"Speculation","subj":"T10941","obj":"true"},{"id":"M203","pred":"Speculation","subj":"T10939","obj":"true"}],"text":"To address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352)."}