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PMC:2791889 / 18158-18476
Annnotations
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11203 | 19-24 | P22301 | denotes | IL-10 |
T11204 | 80-84 | P27361 | denotes | ERK1 |
T11205 | 89-93 | P28482 | denotes | ERK2 |
T11206 | 146-149 | P04234 | denotes | CD3 |
T11207 | 146-149 | P07766 | denotes | CD3 |
T11208 | 146-149 | P09693 | denotes | CD3 |
T11209 | 146-149 | P20963 | denotes | CD3 |
T11210 | 159-163 | P10747 | denotes | CD28 |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T10981 | 19-24 | Protein | denotes | IL-10 | |
T10982 | 25-35 | Gene_expression | denotes | production | |
T10983 | 67-76 | Positive_regulation | denotes | dependent | true |
T10984 | 67-76 | Positive_regulation | denotes | dependent | true |
T10985 | 80-84 | Protein | denotes | ERK1 | |
T10986 | 89-93 | Protein | denotes | ERK2 | |
T10987 | 94-104 | Positive_regulation | denotes | activation | |
T10988 | 94-104 | Positive_regulation | denotes | activation | |
T10989 | 146-149 | Protein | denotes | CD3 | |
T10990 | 159-163 | Protein | denotes | CD28 | |
T10991 | 293-296 | Protein | denotes | MEK | |
T10992 | 297-306 | Negative_regulation | denotes | inhibitor | |
R8454 | T10981 | T10982 | themeOf | IL-10,production | |
R8455 | T10982 | T10983 | themeOf | production,dependent | |
R8456 | T10982 | T10984 | themeOf | production,dependent | |
R8457 | T10985 | T10987 | themeOf | ERK1,activation | |
R8458 | T10986 | T10988 | themeOf | ERK2,activation | |
R8459 | T10987 | T10984 | causeOf | activation,dependent | |
R8460 | T10988 | T10983 | causeOf | activation,dependent | |
R8461 | T10991 | T10992 | themeOf | MEK,inhibitor |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
19646904-16517715-46582694 | 252-256 | 16517715 | denotes | 2006 |
19646904-19114668-46582694 | 252-256 | 19114668 | denotes | 2006 |
19646904-16473830-46582694 | 252-256 | 16473830 | denotes | 2006 |
T40702 | 252-256 | 16517715 | denotes | 2006 |
T58715 | 252-256 | 19114668 | denotes | 2006 |
T81132 | 252-256 | 16473830 | denotes | 2006 |
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11040 | 0-2 | TO | denotes | To |
T11041 | 3-10 | VB | denotes | address |
T11042 | 11-18 | IN | denotes | whether |
T11043 | 19-24 | NN | denotes | IL-10 |
T11044 | 25-35 | NN | denotes | production |
T11045 | 36-38 | IN | denotes | by |
T11046 | 39-42 | NN | denotes | Th2 |
T11047 | 43-46 | CC | denotes | and |
T11048 | 47-51 | NN | denotes | Th17 |
T11049 | 52-57 | NN | denotes | cells |
T11050 | 58-61 | VB | denotes | was |
T11051 | 62-66 | RB | denotes | also |
T11052 | 67-76 | JJ | denotes | dependent |
T11053 | 77-79 | IN | denotes | on |
T11054 | 80-84 | NN | denotes | ERK1 |
T11055 | 85-88 | CC | denotes | and |
T11056 | 89-93 | NN | denotes | ERK2 |
T11057 | 94-104 | NN | denotes | activation |
T11058 | 104-105 | -COMMA- | denotes | , |
T11059 | 106-108 | PRP | denotes | we |
T11060 | 109-123 | VB | denotes | differentiated |
T11061 | 124-129 | DT | denotes | these |
T11062 | 130-135 | NN | denotes | cells |
T11063 | 136-140 | IN | denotes | with |
T11064 | 141-149 | JJ | denotes | anti-CD3 |
T11065 | 150-153 | CC | denotes | and |
T11066 | 154-163 | JJ | denotes | anti-CD28 |
T11067 | 164-166 | IN | denotes | in |
T11068 | 167-170 | DT | denotes | the |
T11069 | 171-178 | NN | denotes | absence |
T11070 | 179-181 | IN | denotes | of |
T11071 | 182-186 | NN | denotes | APCs |
T11072 | 187-188 | -LRB- | denotes | ( |
T11073 | 188-197 | NN | denotes | Shoemaker |
T11074 | 198-204 | NNP | denotes | et al. |
T11075 | 204-205 | -COMMA- | denotes | , |
T11076 | 206-210 | CD | denotes | 2006 |
T11077 | 210-211 | -COLON- | denotes | ; |
T11078 | 212-220 | NNP | denotes | Veldhoen |
T11079 | 221-227 | FW | denotes | et al. |
T11080 | 227-228 | -COMMA- | denotes | , |
T11081 | 229-233 | CD | denotes | 2009 |
T11082 | 233-234 | -COLON- | denotes | ; |
T11083 | 235-243 | NNP | denotes | Veldhoen |
T11084 | 244-250 | FW | denotes | et al. |
T11085 | 250-251 | -COMMA- | denotes | , |
T11086 | 252-256 | CD | denotes | 2006 |
T11087 | 256-257 | -RRB- | denotes | ) |
T11088 | 257-258 | -COMMA- | denotes | , |
T11089 | 259-261 | IN | denotes | in |
T11090 | 262-265 | DT | denotes | the |
T11091 | 266-274 | NN | denotes | presence |
T11092 | 275-277 | CC | denotes | or |
T11093 | 278-285 | NN | denotes | absence |
T11094 | 286-288 | IN | denotes | of |
T11095 | 289-292 | DT | denotes | the |
T11096 | 293-296 | NN | denotes | MEK |
T11097 | 297-306 | NN | denotes | inhibitor |
T11098 | 307-308 | -LRB- | denotes | ( |
T11099 | 308-316 | NN | denotes | PD184352 |
T11100 | 316-317 | -RRB- | denotes | ) |
R8499 | T11041 | T11040 | arg1Of | address,To |
R8500 | T11041 | T11042 | arg1Of | address,whether |
R8501 | T11044 | T11043 | arg1Of | production,IL-10 |
R8502 | T11044 | T11045 | arg1Of | production,by |
R8503 | T11044 | T11050 | arg1Of | production,was |
R8504 | T11044 | T11052 | arg1Of | production,dependent |
R8505 | T11046 | T11047 | arg1Of | Th2,and |
R8506 | T11048 | T11047 | arg2Of | Th17,and |
R8507 | T11049 | T11045 | arg2Of | cells,by |
R8508 | T11049 | T11046 | arg1Of | cells,Th2 |
R8509 | T11049 | T11048 | arg1Of | cells,Th17 |
R8510 | T11050 | T11042 | arg2Of | was,whether |
R8511 | T11050 | T11051 | arg1Of | was,also |
R8512 | T11050 | T11055 | arg1Of | was,and |
R8513 | T11052 | T11050 | arg2Of | dependent,was |
R8514 | T11052 | T11053 | arg1Of | dependent,on |
R8515 | T11054 | T11053 | arg2Of | ERK1,on |
R8516 | T11056 | T11041 | arg2Of | ERK2,address |
R8517 | T11057 | T11041 | arg1Of | activation,address |
R8518 | T11057 | T11058 | arg1Of | activation,"," |
R8519 | T11057 | T11060 | arg1Of | activation,differentiated |
R8520 | T11059 | T11058 | arg2Of | we,"," |
R8521 | T11060 | T11040 | modOf | differentiated,To |
R8522 | T11060 | T11063 | arg1Of | differentiated,with |
R8523 | T11060 | T11067 | arg1Of | differentiated,in |
R8524 | T11060 | T11088 | arg1Of | differentiated,"," |
R8525 | T11060 | T11089 | arg1Of | differentiated,in |
R8526 | T11062 | T11060 | arg2Of | cells,differentiated |
R8527 | T11062 | T11061 | arg1Of | cells,these |
R8528 | T11064 | T11065 | arg1Of | anti-CD3,and |
R8529 | T11065 | T11063 | arg2Of | and,with |
R8530 | T11066 | T11065 | arg2Of | anti-CD28,and |
R8531 | T11069 | T11067 | arg2Of | absence,in |
R8532 | T11069 | T11068 | arg1Of | absence,the |
R8533 | T11069 | T11070 | arg1Of | absence,of |
R8534 | T11071 | T11070 | arg2Of | APCs,of |
R8535 | T11071 | T11072 | arg1Of | APCs,( |
R8536 | T11074 | T11073 | arg1Of | et al.,Shoemaker |
R8537 | T11074 | T11075 | arg1Of | et al.,"," |
R8538 | T11074 | T11077 | arg1Of | et al.,; |
R8539 | T11076 | T11075 | arg2Of | 2006,"," |
R8540 | T11077 | T11082 | arg1Of | ;,; |
R8541 | T11078 | T11077 | arg2Of | Veldhoen,; |
R8542 | T11078 | T11079 | arg1Of | Veldhoen,et al. |
R8543 | T11078 | T11080 | arg1Of | Veldhoen,"," |
R8544 | T11081 | T11080 | arg2Of | 2009,"," |
R8545 | T11082 | T11072 | arg2Of | ;,( |
R8546 | T11083 | T11082 | arg2Of | Veldhoen,; |
R8547 | T11083 | T11084 | arg1Of | Veldhoen,et al. |
R8548 | T11083 | T11085 | arg1Of | Veldhoen,"," |
R8549 | T11086 | T11085 | arg2Of | 2006,"," |
R8550 | T11087 | T11072 | arg3Of | ),( |
R8551 | T11091 | T11092 | arg1Of | presence,or |
R8552 | T11092 | T11089 | arg2Of | or,in |
R8553 | T11092 | T11090 | arg1Of | or,the |
R8554 | T11092 | T11094 | arg1Of | or,of |
R8555 | T11093 | T11092 | arg2Of | absence,or |
R8556 | T11097 | T11094 | arg2Of | inhibitor,of |
R8557 | T11097 | T11095 | arg1Of | inhibitor,the |
R8558 | T11097 | T11096 | arg1Of | inhibitor,MEK |
R8559 | T11097 | T11098 | arg1Of | inhibitor,( |
R8560 | T11099 | T11098 | arg2Of | PD184352,( |
R8561 | T11100 | T11098 | arg3Of | ),( |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11236 | 0-2 | TO | denotes | To |
T11237 | 3-10 | VB | denotes | address |
T11238 | 11-18 | IN | denotes | whether |
T11239 | 19-24 | NN | denotes | IL-10 |
T11240 | 25-35 | NN | denotes | production |
T11241 | 36-38 | IN | denotes | by |
T11242 | 39-42 | NNP | denotes | Th2 |
T11243 | 43-46 | CC | denotes | and |
T11244 | 47-51 | NNP | denotes | Th17 |
T11245 | 52-57 | NNS | denotes | cells |
T11246 | 58-61 | VBD | denotes | was |
T11247 | 62-66 | RB | denotes | also |
T11248 | 67-76 | JJ | denotes | dependent |
T11249 | 77-79 | IN | denotes | on |
T11250 | 80-84 | CD | denotes | ERK1 |
T11251 | 85-88 | CC | denotes | and |
T11252 | 89-93 | CD | denotes | ERK2 |
T11253 | 94-104 | NN | denotes | activation |
T11254 | 104-105 | , | denotes | , |
T11255 | 106-108 | PRP | denotes | we |
T11256 | 109-123 | VBD | denotes | differentiated |
T11257 | 124-129 | DT | denotes | these |
T11258 | 130-135 | NNS | denotes | cells |
T11259 | 136-140 | IN | denotes | with |
T11260 | 141-149 | JJ | denotes | anti-CD3 |
T11261 | 150-153 | CC | denotes | and |
T11262 | 154-163 | JJ | denotes | anti-CD28 |
T11263 | 164-166 | IN | denotes | in |
T11264 | 167-170 | DT | denotes | the |
T11265 | 171-178 | NN | denotes | absence |
T11266 | 179-181 | IN | denotes | of |
T11267 | 182-186 | NNS | denotes | APCs |
T11268 | 187-188 | -LRB- | denotes | ( |
T11269 | 188-197 | NN | denotes | Shoemaker |
T11270 | 198-200 | FW | denotes | et |
T11271 | 201-204 | FW | denotes | al. |
T11272 | 204-205 | , | denotes | , |
T11273 | 206-210 | CD | denotes | 2006 |
T11274 | 210-211 | : | denotes | ; |
T11275 | 212-220 | NNP | denotes | Veldhoen |
T11276 | 221-223 | FW | denotes | et |
T11277 | 224-227 | FW | denotes | al. |
T11278 | 227-228 | , | denotes | , |
T11279 | 229-233 | CD | denotes | 2009 |
T11280 | 233-234 | : | denotes | ; |
T11281 | 235-243 | NNP | denotes | Veldhoen |
T11282 | 244-246 | FW | denotes | et |
T11283 | 247-250 | FW | denotes | al. |
T11284 | 250-251 | , | denotes | , |
T11285 | 252-256 | CD | denotes | 2006 |
T11286 | 256-257 | -RRB- | denotes | ) |
T11287 | 257-258 | , | denotes | , |
T11288 | 259-261 | IN | denotes | in |
T11289 | 262-265 | DT | denotes | the |
T11290 | 266-274 | NN | denotes | presence |
T11291 | 275-277 | CC | denotes | or |
T11292 | 278-285 | NN | denotes | absence |
T11293 | 286-288 | IN | denotes | of |
T11294 | 289-292 | DT | denotes | the |
T11295 | 293-296 | NNP | denotes | MEK |
T11296 | 297-306 | NN | denotes | inhibitor |
T11297 | 307-308 | -LRB- | denotes | ( |
T11298 | 308-316 | NNP | denotes | PD184352 |
T11299 | 316-317 | -RRB- | denotes | ) |
T11300 | 317-318 | . | denotes | . |
R8678 | T11236 | T11237 | aux | To,address |
R8679 | T11237 | T11256 | advcl | address,differentiated |
R8680 | T11238 | T11246 | mark | whether,was |
R8681 | T11239 | T11240 | compound | IL-10,production |
R8682 | T11240 | T11246 | nsubj | production,was |
R8683 | T11241 | T11240 | prep | by,production |
R8684 | T11242 | T11245 | nmod | Th2,cells |
R8685 | T11243 | T11242 | cc | and,Th2 |
R8686 | T11244 | T11242 | conj | Th17,Th2 |
R8687 | T11245 | T11241 | pobj | cells,by |
R8688 | T11246 | T11237 | ccomp | was,address |
R8689 | T11247 | T11246 | advmod | also,was |
R8690 | T11248 | T11246 | acomp | dependent,was |
R8691 | T11249 | T11248 | prep | on,dependent |
R8692 | T11250 | T11253 | nummod | ERK1,activation |
R8693 | T11251 | T11250 | cc | and,ERK1 |
R8694 | T11252 | T11250 | conj | ERK2,ERK1 |
R8695 | T11253 | T11249 | pobj | activation,on |
R8696 | T11254 | T11256 | punct | ",",differentiated |
R8697 | T11255 | T11256 | nsubj | we,differentiated |
R8699 | T11257 | T11258 | det | these,cells |
R8700 | T11258 | T11256 | dobj | cells,differentiated |
R8701 | T11259 | T11256 | prep | with,differentiated |
R8702 | T11260 | T11277 | nmod | anti-CD3,al. |
R8703 | T11261 | T11260 | cc | and,anti-CD3 |
R8704 | T11262 | T11260 | conj | anti-CD28,anti-CD3 |
R8705 | T11263 | T11260 | prep | in,anti-CD3 |
R8706 | T11264 | T11265 | det | the,absence |
R8707 | T11265 | T11263 | pobj | absence,in |
R8708 | T11266 | T11265 | prep | of,absence |
R8709 | T11267 | T11266 | pobj | APCs,of |
R8710 | T11268 | T11271 | punct | (,al. |
R8711 | T11269 | T11271 | compound | Shoemaker,al. |
R8712 | T11270 | T11271 | nmod | et,al. |
R8713 | T11271 | T11265 | appos | al.,absence |
R8714 | T11272 | T11271 | punct | ",",al. |
R8715 | T11273 | T11271 | npadvmod | 2006,al. |
R8716 | T11274 | T11271 | punct | ;,al. |
R8732 | T11290 | T11288 | pobj | presence,in |
R8733 | T11291 | T11290 | cc | or,presence |
R8734 | T11292 | T11290 | conj | absence,presence |
R8735 | T11293 | T11292 | prep | of,absence |
R8736 | T11294 | T11296 | det | the,inhibitor |
R8737 | T11295 | T11296 | compound | MEK,inhibitor |
R8738 | T11296 | T11293 | pobj | inhibitor,of |
R8739 | T11297 | T11298 | punct | (,PD184352 |
R8740 | T11298 | T11296 | appos | PD184352,inhibitor |
R8741 | T11299 | T11256 | punct | ),differentiated |
R8742 | T11300 | T11256 | punct | .,differentiated |
R8717 | T11275 | T11277 | compound | Veldhoen,al. |
R8718 | T11276 | T11277 | compound | et,al. |
R8719 | T11277 | T11259 | pobj | al.,with |
R8720 | T11278 | T11277 | punct | ",",al. |
R8721 | T11279 | T11277 | appos | 2009,al. |
R8722 | T11280 | T11277 | punct | ;,al. |
R8723 | T11281 | T11283 | compound | Veldhoen,al. |
R8724 | T11282 | T11283 | compound | et,al. |
R8725 | T11283 | T11277 | conj | al.,al. |
R8731 | T11289 | T11290 | det | the,presence |
R8726 | T11284 | T11283 | punct | ",",al. |
R8727 | T11285 | T11283 | npadvmod | 2006,al. |
R8728 | T11286 | T11256 | punct | ),differentiated |
R8729 | T11287 | T11256 | punct | ",",differentiated |
R8730 | T11288 | T11256 | prep | in,differentiated |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11412 | 19-35 | http://purl.obolibrary.org/obo/GO_0032653 | denotes | IL-10 production |
T11416 | 19-35 | http://purl.obolibrary.org/obo/GO_0032613 | denotes | IL-10 production |
T11420 | 80-84 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK1 |
T11423 | 89-93 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK2 |
T11427 | 80-104 | http://purl.obolibrary.org/obo/GO_0070374 | denotes | ERK1 and ERK2 activation |
T11429 | 109-135 | http://purl.obolibrary.org/obo/GO_0030154 | denotes | differentiated these cells |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11436 | 19-24 | http://purl.obolibrary.org/obo/GO_0005141 | denotes | IL-10 |
T11442 | 80-84 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK1 |
T11445 | 89-93 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK2 |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11450 | 52-57 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T11451 | 130-135 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11023 | 0-318 | Sentence | denotes | To address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352). |
T94 | 0-318 | Sentence | denotes | To address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352). |
events-check-again
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T11560 | 19-24 | Protein | denotes | IL-10 | |
T11561 | 25-35 | Gene_expression | denotes | production | |
T11562 | 67-76 | Positive_regulation | denotes | dependent | true |
T11563 | 67-76 | Positive_regulation | denotes | dependent | true |
T11564 | 80-84 | Protein | denotes | ERK1 | |
T11565 | 89-93 | Protein | denotes | ERK2 | |
T11566 | 94-104 | Positive_regulation | denotes | activation | |
T11567 | 94-104 | Positive_regulation | denotes | activation | |
T11568 | 146-149 | Protein | denotes | CD3 | |
T11569 | 159-163 | Protein | denotes | CD28 | |
T11570 | 293-296 | Protein | denotes | MEK | |
T11571 | 297-306 | Negative_regulation | denotes | inhibitor | |
R8931 | T11560 | T11561 | themeOf | IL-10,production | |
R8932 | T11561 | T11562 | themeOf | production,dependent | |
R8933 | T11561 | T11563 | themeOf | production,dependent | |
R8934 | T11564 | T11566 | themeOf | ERK1,activation | |
R8935 | T11565 | T11567 | themeOf | ERK2,activation | |
R8936 | T11566 | T11563 | causeOf | activation,dependent | |
R8937 | T11567 | T11562 | causeOf | activation,dependent | |
R8938 | T11570 | T11571 | themeOf | MEK,inhibitor |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11607 | 80-84 | Protein | denotes | ERK1 |
T11608 | 89-93 | Protein | denotes | ERK2 |
T11609 | 141-149 | Protein | denotes | anti-CD3 |
T11610 | 154-163 | Protein | denotes | anti-CD28 |
T11611 | 293-296 | Protein | denotes | MEK |
T11612 | 94-104 | Positive_regulation | denotes | activation |
T11613 | 94-104 | Positive_regulation | denotes | activation |
T11614 | 297-306 | Negative_regulation | denotes | inhibitor |
R8965 | T11607 | T11612 | themeOf | ERK1,activation |
R8966 | T11608 | T11613 | themeOf | ERK2,activation |
R8967 | T11611 | T11614 | themeOf | MEK,inhibitor |
test2
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T10939 | 19-24 | Protein | denotes | IL-10 | true |
T10940 | 25-35 | Gene_expression | denotes | production | |
T10941 | 67-76 | Positive_regulation | denotes | dependent | true |
T10942 | 80-84 | Protein | denotes | ERK1 | |
T10943 | 89-93 | Protein | denotes | ERK2 | |
T10944 | 94-104 | Positive_regulation | denotes | activation | |
T10945 | 146-149 | Protein | denotes | CD3 | |
T10946 | 159-163 | Protein | denotes | CD28 | |
T10947 | 293-296 | Protein | denotes | MEK | |
T10948 | 297-306 | Negative_regulation | denotes | inhibitor | |
R8425 | T10939 | T10940 | themeOf | IL-10,production | |
R8426 | T10940 | T10941 | themeOf | production,dependent | |
R8427 | T10942 | T10944 | themeOf | ERK1,activation | |
R8428 | T10943 | T10944 | themeOf | ERK2,activation | |
R8429 | T10944 | T10941 | causeOf | activation,dependent | |
R8430 | T10947 | T10948 | themeOf | MEK,inhibitor |