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PMC:2791889 / 15575-18078 JSONTXT

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bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T9834 0-5 P22301 denotes IL-10
T9835 39-43 P27361 denotes ERK1
T9836 48-52 P28482 denotes ERK2
T9837 104-109 P22301 denotes IL-10
T9838 243-248 P29459 denotes IL-12
T9839 243-248 P29460 denotes IL-12
T9840 320-324 P27361 denotes ERK1
T9841 329-333 P28482 denotes ERK2
T9842 402-405 P01730 denotes CD4
T9843 496-499 P01730 denotes CD4
T9844 617-621 P27361 denotes ERK1
T9845 626-630 P28482 denotes ERK2
T9846 789-793 P27361 denotes ERK1
T9847 798-802 P28482 denotes ERK2
T9848 833-838 P29459 denotes IL-12
T9849 833-838 P29460 denotes IL-12
T9850 957-961 P27361 denotes ERK1
T9851 966-970 P28482 denotes ERK2
T9852 1016-1021 P22301 denotes IL-10
T9853 1291-1294 P20963 denotes CD3
T9854 1291-1294 P09693 denotes CD3
T9855 1291-1294 P04234 denotes CD3
T9856 1291-1294 P07766 denotes CD3
T9857 1320-1325 P29460 denotes IL-12
T9858 1320-1325 P29459 denotes IL-12
T9859 1397-1402 P29460 denotes IL-12
T9860 1397-1402 P29459 denotes IL-12
T9861 1453-1458 P22301 denotes IL-10
T9862 1463-1468 P01579 denotes IFN-γ
T9863 1568-1573 P22301 denotes IL-10
T9864 1595-1598 P09693 denotes CD3
T9865 1595-1598 P07766 denotes CD3
T9866 1595-1598 P04234 denotes CD3
T9867 1595-1598 P20963 denotes CD3
T9868 1689-1693 Q02750 denotes MEK1
T9869 1699-1703 P36507 denotes MEK2
T9870 1728-1732 P27361 denotes ERK1
T9871 1737-1741 P28482 denotes ERK2
T9872 1837-1841 Q02750 denotes MEK1
T9873 1846-1850 P36507 denotes MEK2
T9874 1909-1913 Q02750 denotes MEK1
T9875 1918-1922 P36507 denotes MEK2
T9876 2016-2021 P22301 denotes IL-10
T9877 2171-2174 Q16539 denotes p38
T9878 2171-2174 O15264 denotes p38
T9879 2171-2174 Q15759 denotes p38
T9880 2171-2174 P53778 denotes p38
T9881 2208-2213 P49841 denotes GSK3β
T9882 2267-2272 P22301 denotes IL-10
T9883 2340-2345 P22301 denotes IL-10
T9884 2407-2412 P29459 denotes IL-12
T9885 2407-2412 P29460 denotes IL-12
T9886 2422-2426 P27361 denotes ERK1
T9887 2431-2435 P28482 denotes ERK2
T9888 2477-2480 O15264 denotes p38
T9889 2477-2480 Q16539 denotes p38
T9890 2477-2480 P53778 denotes p38
T9891 2477-2480 Q15759 denotes p38
T9892 2488-2493 P49841 denotes GSK3β

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T9274 30-38 Positive_regulation denotes Requires
T9275 30-38 Positive_regulation denotes Requires
T9276 39-43 Protein denotes ERK1
T9277 48-52 Protein denotes ERK2
T9278 53-63 Positive_regulation denotes Activation
T9279 53-63 Positive_regulation denotes Activation
T9280 89-100 Positive_regulation denotes maintenance
T9281 104-109 Protein denotes IL-10
T9282 110-119 Gene_expression denotes induction
T9283 133-141 Positive_regulation denotes required
T9284 231-239 Positive_regulation denotes addition
T9285 243-248 Protein denotes IL-12
T9286 303-310 Positive_regulation denotes induced
T9287 303-310 Positive_regulation denotes induced
T9288 320-324 Protein denotes ERK1
T9289 329-333 Protein denotes ERK2
T9290 334-344 Positive_regulation denotes activation
T9291 334-344 Positive_regulation denotes activation
T9292 355-362 Positive_regulation denotes induced
T9293 355-362 Positive_regulation denotes induced
T9294 402-405 Protein denotes CD4
T9295 496-499 Protein denotes CD4
T9296 617-621 Protein denotes ERK1
T9297 626-630 Protein denotes ERK2
T9298 631-641 Positive_regulation denotes activation
T9299 631-641 Positive_regulation denotes activation
T9300 766-774 Positive_regulation denotes enhanced
T9301 766-774 Positive_regulation denotes enhanced
T9302 779-788 Positive_regulation denotes prolonged
T9303 779-788 Positive_regulation denotes prolonged
T9304 789-793 Protein denotes ERK1
T9305 798-802 Protein denotes ERK2
T9306 803-813 Positive_regulation denotes activation
T9307 803-813 Positive_regulation denotes activation
T9308 833-838 Protein denotes IL-12
T9309 957-961 Protein denotes ERK1
T9310 966-970 Protein denotes ERK2
T9311 971-981 Positive_regulation denotes activation
T9312 971-981 Positive_regulation denotes activation
T9313 986-994 Positive_regulation denotes required true
T9314 986-994 Positive_regulation denotes required true
T9315 1003-1012 Positive_regulation denotes induction
T9316 1016-1021 Protein denotes IL-10
T9317 1291-1294 Protein denotes CD3
T9318 1320-1325 Protein denotes IL-12
T9319 1397-1402 Protein denotes IL-12
T9320 1438-1447 Gene_expression denotes producing
T9321 1438-1447 Gene_expression denotes producing
T9322 1453-1458 Protein denotes IL-10
T9323 1463-1468 Protein denotes IFN-γ
T9324 1540-1549 Negative_regulation denotes abrogated
T9325 1554-1564 Gene_expression denotes production
T9326 1568-1573 Protein denotes IL-10
T9327 1595-1598 Protein denotes CD3
T9328 1626-1634 Negative_regulation denotes inhibits
T9329 1626-1634 Negative_regulation denotes inhibits
T9330 1626-1634 Negative_regulation denotes inhibits
T9331 1626-1634 Negative_regulation denotes inhibits
T9332 1626-1634 Negative_regulation denotes inhibits
T9333 1639-1643 Protein denotes MEK5
T9334 1644-1653 Positive_regulation denotes catalyzed
T9335 1654-1664 Positive_regulation denotes activation
T9336 1668-1672 Protein denotes ERK5
T9337 1689-1693 Protein denotes MEK1
T9338 1699-1703 Protein denotes MEK2
T9339 1704-1713 Positive_regulation denotes catalyzed
T9340 1704-1713 Positive_regulation denotes catalyzed
T9341 1704-1713 Positive_regulation denotes catalyzed
T9342 1704-1713 Positive_regulation denotes catalyzed
T9343 1714-1724 Positive_regulation denotes activation
T9344 1714-1724 Positive_regulation denotes activation
T9345 1728-1732 Protein denotes ERK1
T9346 1737-1741 Protein denotes ERK2
T9347 1837-1841 Protein denotes MEK1
T9348 1846-1850 Protein denotes MEK2
T9349 1851-1860 Negative_regulation denotes inhibitor
T9350 1851-1860 Negative_regulation denotes inhibitor
T9351 1900-1908 Negative_regulation denotes inhibits true
T9352 1900-1908 Negative_regulation denotes inhibits
T9353 1900-1908 Negative_regulation denotes inhibits
T9354 1909-1913 Protein denotes MEK1
T9355 1918-1922 Protein denotes MEK2
T9356 1931-1935 Protein denotes MEK5
T9357 2002-2012 Negative_regulation denotes inhibition
T9358 2016-2021 Protein denotes IL-10
T9359 2022-2032 Gene_expression denotes production
T9360 2171-2179 Protein denotes p38 MAPK
T9361 2180-2189 Negative_regulation denotes inhibitor
T9362 2208-2213 Protein denotes GSK3β
T9363 2214-2223 Negative_regulation denotes inhibitor
T9364 2257-2263 Regulation denotes effect true
T9365 2257-2263 Regulation denotes effect true
T9366 2267-2272 Protein denotes IL-10
T9367 2273-2283 Gene_expression denotes production
T9368 2340-2345 Protein denotes IL-10
T9369 2346-2356 Gene_expression denotes production
T9370 2370-2384 Positive_regulation denotes in response to
T9371 2407-2412 Protein denotes IL-12
T9372 2413-2421 Positive_regulation denotes requires true true
T9373 2413-2421 Positive_regulation denotes requires true true
T9374 2422-2426 Protein denotes ERK1
T9375 2431-2435 Protein denotes ERK2
T9376 2459-2469 Positive_regulation denotes activation
T9377 2459-2469 Positive_regulation denotes activation
T9378 2477-2480 Protein denotes p38
T9379 2488-2493 Protein denotes GSK3β
T9270 0-5 Protein denotes IL-10
T9271 6-16 Gene_expression denotes Production
T9272 30-38 Positive_regulation denotes Requires
T9273 30-38 Positive_regulation denotes Requires
R7085 T9277 T9279 themeOf ERK2,Activation
R7089 T9279 T9272 causeOf Activation,Requires
R7090 T9280 T9283 themeOf maintenance,required
R7091 T9281 T9282 themeOf IL-10,induction
R7092 T9282 T9280 themeOf induction,maintenance
R7093 T9285 T9284 themeOf IL-12,addition
R7094 T9288 T9290 themeOf ERK1,activation
R7095 T9289 T9291 themeOf ERK2,activation
R7096 T9290 T9287 themeOf activation,induced
R7097 T9290 T9292 themeOf activation,induced
R7098 T9291 T9286 themeOf activation,induced
R7099 T9291 T9293 themeOf activation,induced
R7100 T9296 T9299 themeOf ERK1,activation
R7101 T9297 T9298 themeOf ERK2,activation
R7102 T9304 T9307 themeOf ERK1,activation
R7103 T9305 T9306 themeOf ERK2,activation
R7104 T9306 T9300 themeOf activation,enhanced
R7105 T9306 T9302 themeOf activation,prolonged
R7106 T9307 T9301 themeOf activation,enhanced
R7107 T9307 T9303 themeOf activation,prolonged
R7108 T9308 T9301 causeOf IL-12,enhanced
R7109 T9308 T9300 causeOf IL-12,enhanced
R7110 T9309 T9312 themeOf ERK1,activation
R7111 T9310 T9311 themeOf ERK2,activation
R7112 T9311 T9314 causeOf activation,required
R7113 T9312 T9313 causeOf activation,required
R7114 T9315 T9313 themeOf induction,required
R7115 T9315 T9314 themeOf induction,required
R7116 T9316 T9315 themeOf IL-10,induction
R7117 T9322 T9321 themeOf IL-10,producing
R7118 T9323 T9320 themeOf IFN-γ,producing
R7119 T9325 T9324 themeOf production,abrogated
R7120 T9326 T9325 themeOf IL-10,production
R7121 T9333 T9334 causeOf MEK5,catalyzed
R7122 T9334 T9328 themeOf catalyzed,inhibits
R7123 T9335 T9334 themeOf activation,catalyzed
R7124 T9336 T9335 themeOf ERK5,activation
R7125 T9337 T9342 causeOf MEK1,catalyzed
R7126 T9337 T9340 causeOf MEK1,catalyzed
R7127 T9338 T9339 causeOf MEK2,catalyzed
R7128 T9338 T9341 causeOf MEK2,catalyzed
R7129 T9339 T9332 themeOf catalyzed,inhibits
R7130 T9340 T9331 themeOf catalyzed,inhibits
R7131 T9341 T9330 themeOf catalyzed,inhibits
R7132 T9342 T9329 themeOf catalyzed,inhibits
R7133 T9343 T9342 themeOf activation,catalyzed
R7134 T9343 T9339 themeOf activation,catalyzed
R7135 T9344 T9340 themeOf activation,catalyzed
R7136 T9344 T9341 themeOf activation,catalyzed
R7137 T9345 T9343 themeOf ERK1,activation
R7138 T9346 T9344 themeOf ERK2,activation
R7139 T9347 T9349 themeOf MEK1,inhibitor
R7140 T9348 T9350 themeOf MEK2,inhibitor
R7141 T9354 T9353 themeOf MEK1,inhibits
R7142 T9355 T9352 themeOf MEK2,inhibits
R7143 T9356 T9351 themeOf MEK5,inhibits
R7144 T9358 T9359 themeOf IL-10,production
R7145 T9359 T9357 themeOf production,inhibition
R7146 T9360 T9361 themeOf p38 MAPK,inhibitor
R7147 T9361 T9364 causeOf inhibitor,effect
R7148 T9362 T9363 themeOf GSK3β,inhibitor
R7149 T9363 T9365 causeOf inhibitor,effect
R7150 T9366 T9367 themeOf IL-10,production
R7151 T9367 T9364 themeOf production,effect
R7152 T9367 T9365 themeOf production,effect
R7153 T9368 T9369 themeOf IL-10,production
R7154 T9369 T9370 themeOf production,in response to
R7155 T9370 T9372 themeOf in response to,requires
R7156 T9370 T9373 themeOf in response to,requires
R7157 T9371 T9370 causeOf IL-12,in response to
R7158 T9376 T9275 themeOf activation,Requires
R7159 T9376 T9272 themeOf activation,Requires
R7160 T9376 T9372 causeOf activation,requires
R7161 T9377 T9273 themeOf activation,Requires
R7162 T9377 T9373 causeOf activation,requires
R7163 T9377 T9274 themeOf activation,Requires
R7164 T9378 T9376 themeOf p38,activation
R7165 T9379 T9377 themeOf GSK3β,activation
R7083 T9270 T9271 themeOf IL-10,Production
R7084 T9276 T9278 themeOf ERK1,Activation
R7086 T9278 T9274 causeOf Activation,Requires
R7087 T9278 T9275 causeOf Activation,Requires
R7088 T9279 T9273 causeOf Activation,Requires

2_test

Id Subject Object Predicate Lexical cue
19646904-12594266-46582690 478-482 12594266 denotes 2003
19646904-17850214-46582691 1775-1779 17850214 denotes 2001
19646904-11478941-46582691 1775-1779 11478941 denotes 2001
19646904-17850214-46582692 1969-1973 17850214 denotes 2001
19646904-11478941-46582692 1969-1973 11478941 denotes 2001
19646904-17850214-46582693 2247-2251 17850214 denotes 2007
T89706 478-482 12594266 denotes 2003
T48317 1775-1779 17850214 denotes 2001
T94732 1775-1779 11478941 denotes 2001
T46911 1969-1973 17850214 denotes 2001
T53244 1969-1973 11478941 denotes 2001
T51427 2247-2251 17850214 denotes 2007

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T9392 0-5 NN denotes IL-10
T9393 6-16 NN denotes Production
T9394 17-19 IN denotes by
T9395 20-23 NN denotes Th1
T9396 24-29 NN denotes Cells
T9397 30-38 VB denotes Requires
T9398 39-43 NN denotes ERK1
T9399 44-47 CC denotes and
T9400 48-52 NN denotes ERK2
T9401 53-63 NN denotes Activation
T9402 64-67 PRP-DOLLAR- denotes Our
T9403 68-72 NN denotes data
T9404 73-79 VB denotes showed
T9405 80-84 IN denotes that
T9406 85-88 DT denotes the
T9407 89-100 NN denotes maintenance
T9408 101-103 IN denotes of
T9409 104-109 NN denotes IL-10
T9410 110-119 NN denotes induction
T9411 120-122 IN denotes in
T9412 123-126 NN denotes Th1
T9413 127-132 NN denotes cells
T9414 133-141 VB denotes required
T9415 142-153 NN denotes stimulation
T9416 154-158 IN denotes with
T9417 159-163 JJ denotes high
T9418 164-171 NN denotes antigen
T9419 172-176 NN denotes dose
T9420 176-177 -COMMA- denotes ,
T9421 178-183 WDT denotes which
T9422 184-186 TO denotes to
T9423 187-191 DT denotes some
T9424 192-198 NN denotes extent
T9425 199-204 MD denotes could
T9426 205-207 VB denotes be
T9427 208-219 VB denotes compensated
T9428 220-223 IN denotes for
T9429 224-226 IN denotes by
T9430 227-230 DT denotes the
T9431 231-239 NN denotes addition
T9432 240-242 IN denotes of
T9433 243-248 NN denotes IL-12
T9434 250-259 VB denotes Signaling
T9435 260-267 IN denotes through
T9436 268-271 DT denotes the
T9437 272-275 NN denotes TCR
T9438 276-280 IN denotes with
T9439 281-285 JJ denotes high
T9440 286-291 NN denotes doses
T9441 292-294 IN denotes of
T9442 295-302 NN denotes antigen
T9443 303-310 VB denotes induced
T9444 311-319 JJ denotes stronger
T9445 320-324 NN denotes ERK1
T9446 325-328 CC denotes and
T9447 329-333 NN denotes ERK2
T9448 334-344 NN denotes activation
T9449 345-349 IN denotes than
T9450 350-354 DT denotes that
T9451 355-362 VB denotes induced
T9452 363-365 IN denotes by
T9453 366-369 JJ denotes low
T9454 370-377 NN denotes antigen
T9455 378-382 NN denotes dose
T9456 382-383 -COMMA- denotes ,
T9457 384-387 RB denotes not
T9458 388-392 RB denotes only
T9459 393-395 IN denotes in
T9460 396-401 JJ denotes naive
T9461 402-406 JJ denotes CD4+
T9462 407-414 NN denotes T cells
T9463 415-416 -LRB- denotes (
T9464 416-420 NN denotes data
T9465 421-424 RB denotes not
T9466 425-430 VB denotes shown
T9467 430-431 -RRB- denotes )
T9468 432-434 IN denotes as
T9469 435-445 RB denotes previously
T9470 446-458 VB denotes demonstrated
T9471 459-460 -LRB- denotes (
T9472 460-469 NNP denotes Jorritsma
T9473 470-476 NNP denotes et al.
T9474 476-477 -COMMA- denotes ,
T9475 478-482 CD denotes 2003
T9476 482-483 -RRB- denotes )
T9477 484-487 CC denotes but
T9478 488-492 RB denotes also
T9479 493-495 IN denotes in
T9480 496-500 JJ denotes CD4+
T9481 501-508 NN denotes T cells
T9482 509-521 VB denotes restimulated
T9483 522-526 IN denotes with
T9484 527-530 DT denotes the
T9485 531-535 JJ denotes same
T9486 536-540 JJ denotes high
T9487 541-544 CC denotes and
T9488 545-548 JJ denotes low
T9489 549-556 NN denotes antigen
T9490 557-562 NN denotes doses
T9491 563-564 -LRB- denotes (
T9492 564-573 NN denotes Figure 5A
T9493 573-574 -RRB- denotes )
T9494 576-584 IN denotes Although
T9495 585-588 DT denotes the
T9496 589-597 JJ denotes apparent
T9497 598-602 NN denotes peak
T9498 603-606 CC denotes and
T9499 607-613 NN denotes amount
T9500 614-616 IN denotes of
T9501 617-621 NN denotes ERK1
T9502 622-625 CC denotes and
T9503 626-630 NN denotes ERK2
T9504 631-641 NN denotes activation
T9505 642-648 VB denotes varied
T9506 649-657 RB denotes slightly
T9507 658-665 IN denotes between
T9508 666-677 NN denotes experiments
T9509 677-678 -COMMA- denotes ,
T9510 679-680 DT denotes a
T9511 681-691 JJ denotes consistent
T9512 692-699 NN denotes finding
T9513 700-703 VB denotes was
T9514 704-708 IN denotes that
T9515 709-713 JJ denotes high
T9516 714-721 NN denotes antigen
T9517 722-726 NN denotes dose
T9518 727-741 VB denotes differentiated
T9519 742-745 NN denotes Th1
T9520 746-751 NN denotes cells
T9521 752-758 RB denotes always
T9522 759-765 VB denotes showed
T9523 766-774 VB denotes enhanced
T9524 775-778 CC denotes and
T9525 779-788 JJ denotes prolonged
T9526 789-793 NN denotes ERK1
T9527 794-797 CC denotes and
T9528 798-802 NN denotes ERK2
T9529 803-813 NN denotes activation
T9530 814-816 IN denotes in
T9531 817-820 DT denotes the
T9532 821-829 NN denotes presence
T9533 830-832 IN denotes of
T9534 833-838 NN denotes IL-12
T9535 838-839 -COMMA- denotes ,
T9536 840-850 RB denotes regardless
T9537 851-853 IN denotes of
T9538 854-861 IN denotes whether
T9539 862-866 PRP denotes they
T9540 867-871 VB denotes were
T9541 872-884 VB denotes restimulated
T9542 885-889 IN denotes with
T9543 890-894 JJ denotes high
T9544 895-897 CC denotes or
T9545 898-901 JJ denotes low
T9546 902-909 NN denotes antigen
T9547 910-914 NN denotes dose
T9548 915-916 -LRB- denotes (
T9549 916-925 NN denotes Figure 5B
T9550 925-926 -RRB- denotes )
T9551 928-930 PRP denotes We
T9552 931-935 RB denotes then
T9553 936-948 VB denotes investigated
T9554 949-956 IN denotes whether
T9555 957-961 NN denotes ERK1
T9556 962-965 CC denotes and
T9557 966-970 NN denotes ERK2
T9558 971-981 NN denotes activation
T9559 982-985 VB denotes was
T9560 986-994 VB denotes required
T9561 995-998 IN denotes for
T9562 999-1002 DT denotes the
T9563 1003-1012 NN denotes induction
T9564 1013-1015 IN denotes of
T9565 1016-1021 NN denotes IL-10
T9566 1022-1024 IN denotes in
T9567 1025-1028 NN denotes Th1
T9568 1029-1034 NN denotes cells
T9569 1035-1037 IN denotes by
T9570 1038-1043 VB denotes using
T9571 1044-1049 NN denotes U0126
T9572 1050-1051 -LRB- denotes (
T9573 1051-1060 NN denotes Figure 5C
T9574 1060-1061 -RRB- denotes )
T9575 1061-1062 -COMMA- denotes ,
T9576 1063-1064 DT denotes a
T9577 1065-1073 NN denotes compound
T9578 1074-1078 WDT denotes that
T9579 1079-1085 VB denotes blocks
T9580 1086-1096 JJ denotes downstream
T9581 1097-1100 NN denotes ERK
T9582 1101-1111 NN denotes activation
T9583 1113-1115 TO denotes To
T9584 1116-1122 VB denotes ensure
T9585 1123-1127 IN denotes that
T9586 1128-1132 RB denotes only
T9587 1133-1139 NN denotes T cell
T9588 1140-1149 NN denotes signaling
T9589 1150-1153 VB denotes was
T9590 1154-1159 VB denotes being
T9591 1160-1168 VB denotes affected
T9592 1169-1171 IN denotes by
T9593 1172-1177 NN denotes U0126
T9594 1177-1178 -COMMA- denotes ,
T9595 1179-1181 PRP denotes we
T9596 1182-1186 VB denotes used
T9597 1187-1189 DT denotes an
T9598 1190-1198 JJ denotes APC-free
T9599 1199-1205 NN denotes system
T9600 1206-1208 IN denotes in
T9601 1209-1214 WDT denotes which
T9602 1215-1218 DT denotes the
T9603 1219-1226 NN denotes T cells
T9604 1227-1231 VB denotes were
T9605 1232-1246 VB denotes differentiated
T9606 1247-1249 IN denotes in
T9607 1250-1253 DT denotes the
T9608 1254-1262 NN denotes presence
T9609 1263-1265 IN denotes of
T9610 1266-1276 VB denotes increasing
T9611 1277-1282 NN denotes doses
T9612 1283-1285 IN denotes of
T9613 1286-1294 NN denotes anti-CD3
T9614 1295-1298 CC denotes and
T9615 1299-1300 DT denotes a
T9616 1301-1309 JJ denotes constant
T9617 1310-1316 NN denotes amount
T9618 1317-1319 IN denotes of
T9619 1320-1325 NN denotes IL-12
T9620 1327-1329 IN denotes As
T9621 1330-1332 IN denotes in
T9622 1333-1336 DT denotes the
T9623 1337-1347 JJ denotes APC-driven
T9624 1348-1356 NN denotes cultures
T9625 1356-1357 -COMMA- denotes ,
T9626 1358-1366 JJ denotes stronger
T9627 1367-1370 NN denotes TCR
T9628 1371-1382 NN denotes stimulation
T9629 1383-1391 RB denotes together
T9630 1392-1396 IN denotes with
T9631 1397-1402 NN denotes IL-12
T9632 1403-1406 VB denotes led
T9633 1407-1409 TO denotes to
T9634 1410-1416 JJ denotes higher
T9635 1417-1428 NN denotes percentages
T9636 1429-1431 IN denotes of
T9637 1432-1437 NN denotes cells
T9638 1438-1447 VB denotes producing
T9639 1448-1452 CC denotes both
T9640 1453-1458 NN denotes IL-10
T9641 1459-1462 CC denotes and
T9642 1463-1468 NN denotes IFN-γ
T9643 1469-1474 IN denotes after
T9644 1475-1476 CD denotes 1
T9645 1477-1481 NN denotes week
T9646 1482-1484 IN denotes of
T9647 1485-1492 NN denotes culture
T9648 1493-1494 -LRB- denotes (
T9649 1494-1503 NN denotes Figure 5C
T9650 1503-1504 -RRB- denotes )
T9651 1506-1514 NN denotes Addition
T9652 1515-1517 IN denotes of
T9653 1518-1523 NN denotes U0126
T9654 1524-1526 TO denotes to
T9655 1527-1530 DT denotes the
T9656 1531-1539 NN denotes cultures
T9657 1540-1549 VB denotes abrogated
T9658 1550-1553 DT denotes the
T9659 1554-1564 NN denotes production
T9660 1565-1567 IN denotes of
T9661 1568-1573 NN denotes IL-10
T9662 1574-1576 IN denotes at
T9663 1577-1580 DT denotes all
T9664 1581-1586 NN denotes doses
T9665 1587-1589 IN denotes of
T9666 1590-1598 NN denotes anti-CD3
T9667 1599-1600 -LRB- denotes (
T9668 1600-1609 NN denotes Figure 5C
T9669 1609-1610 -RRB- denotes )
T9670 1612-1619 IN denotes Because
T9671 1620-1625 NN denotes U0126
T9672 1626-1634 VB denotes inhibits
T9673 1635-1638 DT denotes the
T9674 1639-1653 JJ denotes MEK5-catalyzed
T9675 1654-1664 NN denotes activation
T9676 1665-1667 IN denotes of
T9677 1668-1672 NN denotes ERK5
T9678 1672-1673 -COMMA- denotes ,
T9679 1674-1676 RB denotes as
T9680 1677-1681 RB denotes well
T9681 1682-1684 IN denotes as
T9682 1685-1688 DT denotes the
T9683 1689-1694 NN denotes MEK1-
T9684 1695-1698 CC denotes and
T9685 1699-1713 JJ denotes MEK2-catalyzed
T9686 1714-1724 NN denotes activation
T9687 1725-1727 IN denotes of
T9688 1728-1732 NN denotes ERK1
T9689 1733-1736 CC denotes and
T9690 1737-1741 NN denotes ERK2
T9691 1742-1743 -LRB- denotes (
T9692 1743-1747 NNP denotes Bain
T9693 1748-1754 NNP denotes et al.
T9694 1754-1755 -COMMA- denotes ,
T9695 1756-1760 CD denotes 2007
T9696 1760-1761 -COLON- denotes ;
T9697 1762-1766 NNP denotes Mody
T9698 1767-1773 NNP denotes et al.
T9699 1773-1774 -COMMA- denotes ,
T9700 1775-1779 CD denotes 2001
T9701 1779-1780 -RRB- denotes )
T9702 1780-1781 -COMMA- denotes ,
T9703 1782-1784 PRP denotes we
T9704 1785-1789 RB denotes also
T9705 1790-1794 VB denotes used
T9706 1795-1798 DT denotes the
T9707 1799-1803 RB denotes more
T9708 1804-1812 JJ denotes specific
T9709 1812-1813 -COMMA- denotes ,
T9710 1814-1826 RB denotes structurally
T9711 1827-1836 JJ denotes unrelated
T9712 1837-1841 NN denotes MEK1
T9713 1842-1845 CC denotes and
T9714 1846-1850 NN denotes MEK2
T9715 1851-1860 NN denotes inhibitor
T9716 1861-1869 NN denotes PD184352
T9717 1870-1872 IN denotes at
T9718 1873-1887 NN denotes concentrations
T9719 1888-1890 IN denotes in
T9720 1891-1896 WDT denotes which
T9721 1897-1899 PRP denotes it
T9722 1900-1908 VB denotes inhibits
T9723 1909-1913 NN denotes MEK1
T9724 1914-1917 CC denotes and
T9725 1918-1922 NN denotes MEK2
T9726 1923-1926 CC denotes but
T9727 1927-1930 RB denotes not
T9728 1931-1935 NN denotes MEK5
T9729 1936-1937 -LRB- denotes (
T9730 1937-1941 NNP denotes Bain
T9731 1942-1948 NNP denotes et al.
T9732 1948-1949 -COMMA- denotes ,
T9733 1950-1954 CD denotes 2007
T9734 1954-1955 -COLON- denotes ;
T9735 1956-1960 NNP denotes Mody
T9736 1961-1967 NNP denotes et al.
T9737 1967-1968 -COMMA- denotes ,
T9738 1969-1973 CD denotes 2001
T9739 1973-1974 -RRB- denotes )
T9740 1976-1984 NN denotes PD184352
T9741 1985-1991 VB denotes caused
T9742 1992-1993 DT denotes a
T9743 1994-2001 JJ denotes similar
T9744 2002-2012 NN denotes inhibition
T9745 2013-2015 IN denotes of
T9746 2016-2021 NN denotes IL-10
T9747 2022-2032 NN denotes production
T9748 2033-2035 IN denotes by
T9749 2036-2039 NN denotes Th1
T9750 2040-2045 NN denotes cells
T9751 2046-2048 IN denotes in
T9752 2049-2050 DT denotes a
T9753 2051-2065 JJ denotes dose-dependent
T9754 2066-2073 NN denotes fashion
T9755 2074-2075 -LRB- denotes (
T9756 2075-2084 NN denotes Figure 5D
T9757 2085-2088 CC denotes and
T9758 2089-2099 NN denotes Figure S5A
T9759 2099-2100 -RRB- denotes )
T9760 2102-2106 IN denotes Upon
T9761 2107-2115 NN denotes addition
T9762 2116-2118 IN denotes of
T9763 2119-2129 NN denotes inhibitors
T9764 2130-2132 TO denotes to
T9765 2133-2148 NN denotes other signaling
T9766 2149-2157 NN denotes pathways
T9767 2157-2158 -COMMA- denotes ,
T9768 2159-2168 VB denotes including
T9769 2169-2170 DT denotes a
T9770 2171-2174 NN denotes p38
T9771 2175-2179 NN denotes MAPK
T9772 2180-2189 NN denotes inhibitor
T9773 2189-2190 -COMMA- denotes ,
T9774 2191-2199 NN denotes SB203580
T9775 2199-2200 -COMMA- denotes ,
T9776 2201-2203 CC denotes or
T9777 2204-2207 DT denotes the
T9778 2208-2213 NN denotes GSK3β
T9779 2214-2223 NN denotes inhibitor
T9780 2223-2224 -COMMA- denotes ,
T9781 2225-2232 NN denotes CT99021
T9782 2233-2234 -LRB- denotes (
T9783 2234-2238 NNP denotes Bain
T9784 2239-2245 NNP denotes et al.
T9785 2245-2246 -COMMA- denotes ,
T9786 2247-2251 CD denotes 2007
T9787 2251-2252 -RRB- denotes )
T9788 2252-2253 -COMMA- denotes ,
T9789 2254-2256 DT denotes no
T9790 2257-2263 NN denotes effect
T9791 2264-2266 IN denotes on
T9792 2267-2272 NN denotes IL-10
T9793 2273-2283 NN denotes production
T9794 2284-2287 VB denotes was
T9795 2288-2296 VB denotes observed
T9796 2297-2298 -LRB- denotes (
T9797 2298-2308 NN denotes Figure S5B
T9798 2308-2309 -RRB- denotes )
T9799 2311-2314 PRP-DOLLAR- denotes Our
T9800 2315-2319 NN denotes data
T9801 2320-2324 RB denotes thus
T9802 2325-2334 VB denotes suggested
T9803 2335-2339 IN denotes that
T9804 2340-2345 NN denotes IL-10
T9805 2346-2356 NN denotes production
T9806 2357-2359 IN denotes by
T9807 2360-2363 NN denotes Th1
T9808 2364-2369 NN denotes cells
T9809 2370-2372 IN denotes in
T9810 2373-2381 NN denotes response
T9811 2382-2384 TO denotes to
T9812 2385-2389 JJ denotes high
T9813 2390-2397 NN denotes antigen
T9814 2398-2402 NN denotes dose
T9815 2403-2406 CC denotes and
T9816 2407-2412 NN denotes IL-12
T9817 2413-2421 VB denotes requires
T9818 2422-2426 NN denotes ERK1
T9819 2427-2430 CC denotes and
T9820 2431-2435 NN denotes ERK2
T9821 2436-2445 NN denotes signaling
T9822 2445-2446 -COMMA- denotes ,
T9823 2447-2450 CC denotes but
T9824 2451-2454 RB denotes not
T9825 2455-2458 DT denotes the
T9826 2459-2469 NN denotes activation
T9827 2470-2472 IN denotes of
T9828 2473-2476 DT denotes the
T9829 2477-2480 NN denotes p38
T9830 2481-2483 CC denotes or
T9831 2484-2487 DT denotes the
T9832 2488-2493 NN denotes GSK3β
T9833 2494-2502 NN denotes pathways
R7166 T9393 T9392 arg1Of Production,IL-10
R7167 T9393 T9394 arg1Of Production,by
R7168 T9393 T9397 arg1Of Production,Requires
R7169 T9396 T9394 arg2Of Cells,by
R7170 T9396 T9395 arg1Of Cells,Th1
R7171 T9398 T9399 arg1Of ERK1,and
R7172 T9400 T9399 arg2Of ERK2,and
R7173 T9401 T9397 arg2Of Activation,Requires
R7174 T9401 T9398 arg1Of Activation,ERK1
R7175 T9401 T9400 arg1Of Activation,ERK2
R7176 T9403 T9402 arg1Of data,Our
R7177 T9403 T9404 arg1Of data,showed
R7178 T9407 T9406 arg1Of maintenance,the
R7179 T9407 T9408 arg1Of maintenance,of
R7180 T9407 T9411 arg1Of maintenance,in
R7181 T9407 T9414 arg1Of maintenance,required
R7182 T9410 T9408 arg2Of induction,of
R7183 T9410 T9409 arg1Of induction,IL-10
R7184 T9413 T9411 arg2Of cells,in
R7185 T9413 T9412 arg1Of cells,Th1
R7186 T9414 T9404 arg2Of required,showed
R7187 T9414 T9405 arg1Of required,that
R7188 T9415 T9414 arg2Of stimulation,required
R7189 T9415 T9416 arg1Of stimulation,with
R7190 T9419 T9416 arg2Of dose,with
R7191 T9419 T9417 arg1Of dose,high
R7192 T9419 T9418 arg1Of dose,antigen
R7193 T9419 T9420 arg1Of dose,","
R7194 T9419 T9421 arg1Of dose,which
R7195 T9419 T9425 arg1Of dose,could
R7196 T9419 T9426 arg1Of dose,be
R7197 T9419 T9427 arg2Of dose,compensated
R7198 T9424 T9422 arg2Of extent,to
R7199 T9424 T9423 arg1Of extent,some
R7200 T9427 T9422 arg1Of compensated,to
R7201 T9427 T9425 arg2Of compensated,could
R7202 T9427 T9426 arg2Of compensated,be
R7203 T9427 T9428 arg1Of compensated,for
R7204 T9427 T9429 arg1Of compensated,by
R7205 T9431 T9429 arg2Of addition,by
R7206 T9431 T9430 arg1Of addition,the
R7207 T9431 T9432 arg1Of addition,of
R7208 T9433 T9432 arg2Of IL-12,of
R7209 T9434 T9435 arg1Of Signaling,through
R7210 T9434 T9443 arg1Of Signaling,induced
R7211 T9437 T9435 arg2Of TCR,through
R7212 T9437 T9436 arg1Of TCR,the
R7213 T9437 T9438 arg1Of TCR,with
R7214 T9440 T9438 arg2Of doses,with
R7215 T9440 T9439 arg1Of doses,high
R7216 T9440 T9441 arg1Of doses,of
R7217 T9442 T9441 arg2Of antigen,of
R7218 T9443 T9459 arg1Of induced,in
R7219 T9443 T9468 arg1Of induced,as
R7220 T9443 T9479 arg1Of induced,in
R7221 T9445 T9444 arg1Of ERK1,stronger
R7222 T9445 T9446 arg1Of ERK1,and
R7223 T9446 T9443 arg2Of and,induced
R7224 T9446 T9449 arg1Of and,than
R7225 T9448 T9446 arg2Of activation,and
R7226 T9448 T9447 arg1Of activation,ERK2
R7227 T9450 T9449 arg2Of that,than
R7228 T9450 T9451 arg2Of that,induced
R7229 T9455 T9451 arg1Of dose,induced
R7230 T9455 T9452 arg2Of dose,by
R7231 T9455 T9453 arg1Of dose,low
R7232 T9455 T9454 arg1Of dose,antigen
R7233 T9458 T9456 arg1Of only,","
R7234 T9458 T9457 arg1Of only,not
R7235 T9459 T9458 arg1Of in,only
R7236 T9462 T9459 arg2Of T cells,in
R7237 T9462 T9460 arg1Of T cells,naive
R7238 T9462 T9461 arg1Of T cells,CD4+
R7239 T9462 T9463 arg1Of T cells,(
R7240 T9464 T9463 arg2Of data,(
R7241 T9464 T9466 arg2Of data,shown
R7242 T9466 T9465 arg1Of shown,not
R7243 T9467 T9463 arg3Of ),(
R7244 T9468 T9477 arg1Of as,but
R7245 T9470 T9469 arg1Of demonstrated,previously
R7246 T9473 T9468 arg2Of et al.,as
R7247 T9473 T9470 arg1Of et al.,demonstrated
R7248 T9473 T9471 arg2Of et al.,(
R7249 T9473 T9472 arg1Of et al.,Jorritsma
R7250 T9473 T9474 arg1Of et al.,","
R7251 T9475 T9474 arg2Of 2003,","
R7252 T9476 T9471 arg3Of ),(
R7253 T9477 T9478 arg1Of but,also
R7254 T9479 T9477 arg2Of in,but
R7255 T9481 T9479 arg2Of T cells,in
R7256 T9481 T9480 arg1Of T cells,CD4+
R7257 T9481 T9482 arg2Of T cells,restimulated
R7258 T9482 T9483 arg1Of restimulated,with
R7259 T9486 T9487 arg1Of high,and
R7260 T9488 T9487 arg2Of low,and
R7261 T9490 T9483 arg2Of doses,with
R7262 T9490 T9484 arg1Of doses,the
R7263 T9490 T9485 arg1Of doses,same
R7264 T9490 T9486 arg1Of doses,high
R7265 T9490 T9488 arg1Of doses,low
R7266 T9490 T9489 arg1Of doses,antigen
R7267 T9490 T9491 arg1Of doses,(
R7268 T9492 T9491 arg2Of Figure 5A,(
R7269 T9493 T9491 arg3Of ),(
R7270 T9497 T9498 arg1Of peak,and
R7271 T9498 T9495 arg1Of and,the
R7272 T9498 T9496 arg1Of and,apparent
R7273 T9498 T9500 arg1Of and,of
R7274 T9498 T9505 arg1Of and,varied
R7275 T9499 T9498 arg2Of amount,and
R7276 T9501 T9502 arg1Of ERK1,and
R7277 T9503 T9502 arg2Of ERK2,and
R7278 T9504 T9500 arg2Of activation,of
R7279 T9504 T9501 arg1Of activation,ERK1
R7280 T9504 T9503 arg1Of activation,ERK2
R7281 T9505 T9494 arg2Of varied,Although
R7282 T9505 T9506 arg1Of varied,slightly
R7283 T9505 T9507 arg1Of varied,between
R7284 T9508 T9507 arg2Of experiments,between
R7285 T9512 T9510 arg1Of finding,a
R7286 T9512 T9511 arg1Of finding,consistent
R7287 T9512 T9513 arg1Of finding,was
R7288 T9513 T9494 arg1Of was,Although
R7289 T9513 T9509 arg1Of was,","
R7290 T9517 T9515 arg1Of dose,high
R7291 T9517 T9516 arg1Of dose,antigen
R7292 T9517 T9518 arg1Of dose,differentiated
R7293 T9518 T9513 arg2Of differentiated,was
R7294 T9518 T9514 arg1Of differentiated,that
R7295 T9519 T9522 modOf Th1,showed
R7296 T9519 T9537 arg1Of Th1,of
R7297 T9520 T9522 arg1Of cells,showed
R7298 T9522 T9521 arg1Of showed,always
R7299 T9522 T9535 arg1Of showed,","
R7300 T9522 T9536 arg1Of showed,regardless
R7301 T9523 T9524 arg1Of enhanced,and
R7302 T9525 T9524 arg2Of prolonged,and
R7303 T9526 T9523 arg1Of ERK1,enhanced
R7304 T9526 T9525 arg1Of ERK1,prolonged
R7305 T9526 T9527 arg1Of ERK1,and
R7306 T9527 T9522 arg2Of and,showed
R7307 T9527 T9530 arg1Of and,in
R7308 T9529 T9527 arg2Of activation,and
R7309 T9529 T9528 arg1Of activation,ERK2
R7310 T9532 T9530 arg2Of presence,in
R7311 T9532 T9531 arg1Of presence,the
R7312 T9532 T9533 arg1Of presence,of
R7313 T9534 T9533 arg2Of IL-12,of
R7314 T9539 T9540 arg1Of they,were
R7315 T9539 T9541 arg2Of they,restimulated
R7316 T9541 T9537 arg2Of restimulated,of
R7317 T9541 T9538 arg1Of restimulated,whether
R7318 T9541 T9540 arg2Of restimulated,were
R7319 T9541 T9542 arg1Of restimulated,with
R7320 T9543 T9542 arg2Of high,with
R7321 T9547 T9518 arg2Of dose,differentiated
R7322 T9547 T9519 arg1Of dose,Th1
R7323 T9547 T9544 arg1Of dose,or
R7324 T9547 T9545 arg1Of dose,low
R7325 T9547 T9546 arg1Of dose,antigen
R7326 T9547 T9548 arg1Of dose,(
R7327 T9549 T9548 arg2Of Figure 5B,(
R7328 T9550 T9548 arg3Of ),(
R7329 T9551 T9553 arg1Of We,investigated
R7330 T9553 T9552 arg1Of investigated,then
R7331 T9555 T9556 arg1Of ERK1,and
R7332 T9557 T9556 arg2Of ERK2,and
R7333 T9558 T9555 arg1Of activation,ERK1
R7334 T9558 T9557 arg1Of activation,ERK2
R7335 T9558 T9559 arg1Of activation,was
R7336 T9558 T9560 arg2Of activation,required
R7337 T9558 T9570 arg1Of activation,using
R7338 T9560 T9553 arg2Of required,investigated
R7339 T9560 T9554 arg1Of required,whether
R7340 T9560 T9559 arg2Of required,was
R7341 T9560 T9561 arg1Of required,for
R7342 T9560 T9569 arg1Of required,by
R7343 T9563 T9561 arg2Of induction,for
R7344 T9563 T9562 arg1Of induction,the
R7345 T9563 T9564 arg1Of induction,of
R7346 T9563 T9566 arg1Of induction,in
R7347 T9565 T9564 arg2Of IL-10,of
R7348 T9568 T9566 arg2Of cells,in
R7349 T9568 T9567 arg1Of cells,Th1
R7350 T9570 T9569 arg2Of using,by
R7351 T9571 T9570 arg2Of U0126,using
R7352 T9571 T9572 arg1Of U0126,(
R7353 T9571 T9575 arg1Of U0126,","
R7354 T9573 T9572 arg2Of Figure 5C,(
R7355 T9574 T9572 arg3Of ),(
R7356 T9577 T9575 arg2Of compound,","
R7357 T9577 T9576 arg1Of compound,a
R7358 T9577 T9578 arg1Of compound,that
R7359 T9577 T9579 arg1Of compound,blocks
R7360 T9582 T9579 arg2Of activation,blocks
R7361 T9582 T9580 arg1Of activation,downstream
R7362 T9582 T9581 arg1Of activation,ERK
R7363 T9584 T9583 arg1Of ensure,To
R7364 T9588 T9586 arg1Of signaling,only
R7365 T9588 T9587 arg1Of signaling,T cell
R7366 T9588 T9589 arg1Of signaling,was
R7367 T9588 T9590 arg1Of signaling,being
R7368 T9588 T9591 arg2Of signaling,affected
R7369 T9591 T9584 arg2Of affected,ensure
R7370 T9591 T9585 arg1Of affected,that
R7371 T9591 T9589 arg2Of affected,was
R7372 T9591 T9590 arg2Of affected,being
R7373 T9593 T9591 arg1Of U0126,affected
R7374 T9593 T9592 arg2Of U0126,by
R7375 T9595 T9584 arg1Of we,ensure
R7376 T9595 T9596 arg1Of we,used
R7377 T9596 T9583 modOf used,To
R7378 T9596 T9594 arg1Of used,","
R7379 T9599 T9596 arg2Of system,used
R7380 T9599 T9597 arg1Of system,an
R7381 T9599 T9598 arg1Of system,APC-free
R7382 T9599 T9600 arg2Of system,in
R7383 T9599 T9601 arg1Of system,which
R7384 T9603 T9602 arg1Of T cells,the
R7385 T9603 T9604 arg1Of T cells,were
R7386 T9603 T9605 arg2Of T cells,differentiated
R7387 T9605 T9600 arg1Of differentiated,in
R7388 T9605 T9604 arg2Of differentiated,were
R7389 T9605 T9606 arg1Of differentiated,in
R7390 T9608 T9607 arg1Of presence,the
R7391 T9608 T9609 arg1Of presence,of
R7392 T9608 T9614 arg1Of presence,and
R7393 T9611 T9609 arg2Of doses,of
R7394 T9611 T9610 arg1Of doses,increasing
R7395 T9611 T9612 arg1Of doses,of
R7396 T9613 T9612 arg2Of anti-CD3,of
R7397 T9614 T9606 arg2Of and,in
R7398 T9617 T9614 arg2Of amount,and
R7399 T9617 T9615 arg1Of amount,a
R7400 T9617 T9616 arg1Of amount,constant
R7401 T9617 T9618 arg1Of amount,of
R7402 T9619 T9618 arg2Of IL-12,of
R7403 T9621 T9620 arg1Of in,As
R7404 T9624 T9621 arg2Of cultures,in
R7405 T9624 T9622 arg1Of cultures,the
R7406 T9624 T9623 arg1Of cultures,APC-driven
R7407 T9628 T9626 arg1Of stimulation,stronger
R7408 T9628 T9627 arg1Of stimulation,TCR
R7409 T9628 T9629 arg1Of stimulation,together
R7410 T9628 T9632 arg1Of stimulation,led
R7411 T9629 T9630 arg1Of together,with
R7412 T9631 T9630 arg2Of IL-12,with
R7413 T9632 T9621 arg1Of led,in
R7414 T9632 T9625 arg1Of led,","
R7415 T9632 T9633 arg1Of led,to
R7416 T9635 T9633 arg2Of percentages,to
R7417 T9635 T9634 arg1Of percentages,higher
R7418 T9635 T9636 arg1Of percentages,of
R7419 T9637 T9636 arg2Of cells,of
R7420 T9637 T9638 arg1Of cells,producing
R7421 T9638 T9643 arg1Of producing,after
R7422 T9640 T9641 arg1Of IL-10,and
R7423 T9641 T9638 arg2Of and,producing
R7424 T9641 T9639 arg1Of and,both
R7425 T9642 T9641 arg2Of IFN-γ,and
R7426 T9645 T9643 arg2Of week,after
R7427 T9645 T9644 arg1Of week,1
R7428 T9645 T9646 arg1Of week,of
R7429 T9647 T9646 arg2Of culture,of
R7430 T9647 T9648 arg1Of culture,(
R7431 T9649 T9648 arg2Of Figure 5C,(
R7432 T9650 T9648 arg3Of ),(
R7433 T9651 T9652 arg1Of Addition,of
R7434 T9651 T9654 arg1Of Addition,to
R7435 T9651 T9657 arg1Of Addition,abrogated
R7436 T9653 T9652 arg2Of U0126,of
R7437 T9656 T9654 arg2Of cultures,to
R7438 T9656 T9655 arg1Of cultures,the
R7439 T9659 T9657 arg2Of production,abrogated
R7440 T9659 T9658 arg1Of production,the
R7441 T9659 T9660 arg1Of production,of
R7442 T9659 T9662 arg1Of production,at
R7443 T9661 T9660 arg2Of IL-10,of
R7444 T9664 T9662 arg2Of doses,at
R7445 T9664 T9663 arg1Of doses,all
R7446 T9664 T9665 arg1Of doses,of
R7447 T9666 T9665 arg2Of anti-CD3,of
R7448 T9666 T9667 arg1Of anti-CD3,(
R7449 T9668 T9667 arg2Of Figure 5C,(
R7450 T9669 T9667 arg3Of ),(
R7451 T9671 T9672 arg1Of U0126,inhibits
R7452 T9672 T9670 arg2Of inhibits,Because
R7453 T9675 T9673 arg1Of activation,the
R7454 T9675 T9674 arg1Of activation,MEK5-catalyzed
R7455 T9675 T9676 arg1Of activation,of
R7456 T9675 T9681 arg1Of activation,as
R7457 T9677 T9676 arg2Of ERK5,of
R7458 T9681 T9672 arg2Of as,inhibits
R7459 T9681 T9678 arg1Of as,","
R7460 T9681 T9679 arg1Of as,as
R7461 T9681 T9680 arg1Of as,well
R7462 T9683 T9684 arg1Of MEK1-,and
R7463 T9684 T9681 arg2Of and,as
R7464 T9684 T9682 arg1Of and,the
R7465 T9686 T9684 arg2Of activation,and
R7466 T9686 T9685 arg1Of activation,MEK2-catalyzed
R7467 T9686 T9687 arg1Of activation,of
R7468 T9688 T9689 arg1Of ERK1,and
R7469 T9689 T9687 arg2Of and,of
R7470 T9689 T9691 arg1Of and,(
R7471 T9690 T9689 arg2Of ERK2,and
R7472 T9693 T9692 arg1Of et al.,Bain
R7473 T9693 T9694 arg1Of et al.,","
R7474 T9693 T9696 arg1Of et al.,;
R7475 T9695 T9694 arg2Of 2007,","
R7476 T9696 T9691 arg2Of ;,(
R7477 T9698 T9696 arg2Of et al.,;
R7478 T9698 T9697 arg1Of et al.,Mody
R7479 T9698 T9699 arg1Of et al.,","
R7480 T9700 T9699 arg2Of 2001,","
R7481 T9701 T9691 arg3Of ),(
R7482 T9703 T9705 arg1Of we,used
R7483 T9705 T9670 arg1Of used,Because
R7484 T9705 T9702 arg1Of used,","
R7485 T9705 T9704 arg1Of used,also
R7486 T9705 T9717 arg1Of used,at
R7487 T9708 T9707 arg1Of specific,more
R7488 T9708 T9709 arg1Of specific,","
R7489 T9711 T9709 arg2Of unrelated,","
R7490 T9711 T9710 arg1Of unrelated,structurally
R7491 T9712 T9713 arg1Of MEK1,and
R7492 T9713 T9705 arg2Of and,used
R7493 T9713 T9706 arg1Of and,the
R7494 T9713 T9708 arg1Of and,specific
R7495 T9713 T9711 arg1Of and,unrelated
R7496 T9716 T9713 arg2Of PD184352,and
R7497 T9716 T9714 arg1Of PD184352,MEK2
R7498 T9716 T9715 arg1Of PD184352,inhibitor
R7499 T9718 T9717 arg2Of concentrations,at
R7500 T9718 T9719 arg2Of concentrations,in
R7501 T9718 T9720 arg1Of concentrations,which
R7502 T9721 T9722 arg1Of it,inhibits
R7503 T9722 T9719 arg1Of inhibits,in
R7504 T9723 T9724 arg1Of MEK1,and
R7505 T9724 T9726 arg1Of and,but
R7506 T9725 T9724 arg2Of MEK2,and
R7507 T9726 T9722 arg2Of but,inhibits
R7508 T9726 T9727 arg1Of but,not
R7509 T9728 T9726 arg2Of MEK5,but
R7510 T9728 T9729 arg1Of MEK5,(
R7511 T9731 T9730 arg1Of et al.,Bain
R7512 T9731 T9732 arg1Of et al.,","
R7513 T9731 T9734 arg1Of et al.,;
R7514 T9733 T9732 arg2Of 2007,","
R7515 T9734 T9729 arg2Of ;,(
R7516 T9736 T9734 arg2Of et al.,;
R7517 T9736 T9735 arg1Of et al.,Mody
R7518 T9736 T9737 arg1Of et al.,","
R7519 T9738 T9737 arg2Of 2001,","
R7520 T9739 T9729 arg3Of ),(
R7521 T9740 T9741 arg1Of PD184352,caused
R7522 T9741 T9751 arg1Of caused,in
R7523 T9744 T9741 arg2Of inhibition,caused
R7524 T9744 T9742 arg1Of inhibition,a
R7525 T9744 T9743 arg1Of inhibition,similar
R7526 T9744 T9745 arg1Of inhibition,of
R7527 T9744 T9748 arg1Of inhibition,by
R7528 T9747 T9745 arg2Of production,of
R7529 T9747 T9746 arg1Of production,IL-10
R7530 T9750 T9748 arg2Of cells,by
R7531 T9750 T9749 arg1Of cells,Th1
R7532 T9754 T9751 arg2Of fashion,in
R7533 T9754 T9752 arg1Of fashion,a
R7534 T9754 T9753 arg1Of fashion,dose-dependent
R7535 T9754 T9755 arg1Of fashion,(
R7536 T9756 T9757 arg1Of Figure 5D,and
R7537 T9757 T9755 arg2Of and,(
R7538 T9758 T9757 arg2Of Figure S5A,and
R7539 T9759 T9755 arg3Of ),(
R7540 T9761 T9760 arg2Of addition,Upon
R7541 T9761 T9762 arg1Of addition,of
R7542 T9761 T9764 arg1Of addition,to
R7543 T9763 T9762 arg2Of inhibitors,of
R7544 T9766 T9764 arg2Of pathways,to
R7545 T9766 T9765 arg1Of pathways,other signaling
R7546 T9766 T9767 arg1Of pathways,","
R7547 T9766 T9768 arg1Of pathways,including
R7548 T9772 T9769 arg1Of inhibitor,a
R7549 T9772 T9770 arg1Of inhibitor,p38
R7550 T9772 T9771 arg1Of inhibitor,MAPK
R7551 T9772 T9773 arg1Of inhibitor,","
R7552 T9772 T9776 arg1Of inhibitor,or
R7553 T9774 T9773 arg2Of SB203580,","
R7554 T9776 T9768 arg2Of or,including
R7555 T9776 T9775 arg1Of or,","
R7556 T9779 T9776 arg2Of inhibitor,or
R7557 T9779 T9777 arg1Of inhibitor,the
R7558 T9779 T9778 arg1Of inhibitor,GSK3β
R7559 T9779 T9780 arg1Of inhibitor,","
R7560 T9781 T9780 arg2Of CT99021,","
R7561 T9781 T9782 arg1Of CT99021,(
R7562 T9784 T9782 arg2Of et al.,(
R7563 T9784 T9783 arg1Of et al.,Bain
R7564 T9784 T9785 arg1Of et al.,","
R7565 T9786 T9785 arg2Of 2007,","
R7566 T9787 T9782 arg3Of ),(
R7567 T9790 T9789 arg1Of effect,no
R7568 T9790 T9791 arg1Of effect,on
R7569 T9790 T9794 arg1Of effect,was
R7570 T9790 T9795 arg2Of effect,observed
R7571 T9793 T9791 arg2Of production,on
R7572 T9793 T9792 arg1Of production,IL-10
R7573 T9795 T9760 arg1Of observed,Upon
R7574 T9795 T9788 arg1Of observed,","
R7575 T9795 T9794 arg2Of observed,was
R7576 T9795 T9796 arg1Of observed,(
R7577 T9797 T9796 arg2Of Figure S5B,(
R7578 T9798 T9796 arg3Of ),(
R7579 T9800 T9799 arg1Of data,Our
R7580 T9800 T9802 arg1Of data,suggested
R7581 T9802 T9801 arg1Of suggested,thus
R7582 T9805 T9804 arg1Of production,IL-10
R7583 T9805 T9806 arg1Of production,by
R7584 T9805 T9817 arg1Of production,requires
R7585 T9808 T9806 arg2Of cells,by
R7586 T9808 T9807 arg1Of cells,Th1
R7587 T9808 T9809 arg1Of cells,in
R7588 T9810 T9809 arg2Of response,in
R7589 T9810 T9811 arg1Of response,to
R7590 T9814 T9812 arg1Of dose,high
R7591 T9814 T9813 arg1Of dose,antigen
R7592 T9814 T9815 arg1Of dose,and
R7593 T9815 T9811 arg2Of and,to
R7594 T9816 T9815 arg2Of IL-12,and
R7595 T9817 T9802 arg2Of requires,suggested
R7596 T9817 T9803 arg1Of requires,that
R7597 T9818 T9819 arg1Of ERK1,and
R7598 T9819 T9823 arg1Of and,but
R7599 T9821 T9819 arg2Of signaling,and
R7600 T9821 T9820 arg1Of signaling,ERK2
R7601 T9823 T9817 arg2Of but,requires
R7602 T9823 T9822 arg1Of but,","
R7603 T9823 T9824 arg1Of but,not
R7604 T9826 T9823 arg2Of activation,but
R7605 T9826 T9825 arg1Of activation,the
R7606 T9826 T9827 arg1Of activation,of
R7607 T9829 T9828 arg1Of p38,the
R7608 T9829 T9830 arg1Of p38,or
R7609 T9830 T9827 arg2Of or,of
R7610 T9833 T9830 arg2Of pathways,or
R7611 T9833 T9831 arg1Of pathways,the
R7612 T9833 T9832 arg1Of pathways,GSK3β

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T9893 0-5 NNP denotes IL-10
T9894 6-16 NNP denotes Production
T9895 17-19 IN denotes by
T9896 20-23 NNP denotes Th1
T9897 24-29 NNP denotes Cells
T9898 30-38 VBZ denotes Requires
T9899 39-43 CD denotes ERK1
T9900 44-47 CC denotes and
T9901 48-52 CD denotes ERK2
T9902 53-63 NNP denotes Activation
T9903 64-67 PRP$ denotes Our
T9904 68-72 NNS denotes data
T9905 73-79 VBD denotes showed
T9906 80-84 IN denotes that
T9907 85-88 DT denotes the
T9908 89-100 NN denotes maintenance
T9909 101-103 IN denotes of
T9910 104-109 NNP denotes IL-10
T9911 110-119 NN denotes induction
T9912 120-122 IN denotes in
T9913 123-126 JJ denotes Th1
T9914 127-132 NNS denotes cells
T9915 133-141 VBN denotes required
T9916 142-153 NN denotes stimulation
T9917 154-158 IN denotes with
T9918 159-163 JJ denotes high
T9919 164-171 NN denotes antigen
T9920 172-176 NN denotes dose
T9921 176-177 , denotes ,
T9922 178-183 WDT denotes which
T9923 184-186 TO denotes to
T9924 187-191 DT denotes some
T9925 192-198 NN denotes extent
T9926 199-204 MD denotes could
T9927 205-207 VB denotes be
T9928 208-219 VBN denotes compensated
T9929 220-223 IN denotes for
T9930 224-226 IN denotes by
T9931 227-230 DT denotes the
T9932 231-239 NN denotes addition
T9933 240-242 IN denotes of
T9934 243-248 NN denotes IL-12
T9935 248-249 . denotes .
T9936 250-259 VBG denotes Signaling
T9937 260-267 IN denotes through
T9938 268-271 DT denotes the
T9939 272-275 NNP denotes TCR
T9940 276-280 IN denotes with
T9941 281-285 JJ denotes high
T9942 286-291 NNS denotes doses
T9943 292-294 IN denotes of
T9944 295-302 NN denotes antigen
T9945 303-310 VBD denotes induced
T9946 311-319 JJR denotes stronger
T9947 320-324 NNP denotes ERK1
T9948 325-328 CC denotes and
T9949 329-333 NNP denotes ERK2
T9950 334-344 NN denotes activation
T9951 345-349 IN denotes than
T9952 350-354 DT denotes that
T9953 355-362 VBN denotes induced
T9954 363-365 IN denotes by
T9955 366-369 JJ denotes low
T9956 370-377 NN denotes antigen
T9957 378-382 NN denotes dose
T9958 382-383 , denotes ,
T9959 384-387 RB denotes not
T9960 388-392 RB denotes only
T9961 393-395 IN denotes in
T9962 396-401 JJ denotes naive
T9963 402-405 NNP denotes CD4
T9964 405-406 CD denotes +
T9965 407-408 NNP denotes T
T9966 409-414 NNS denotes cells
T9967 415-416 -LRB- denotes (
T9968 416-420 NNS denotes data
T9969 421-424 RB denotes not
T9970 425-430 VBN denotes shown
T9971 430-431 -RRB- denotes )
T9972 432-434 IN denotes as
T9973 435-445 RB denotes previously
T9974 446-458 VBN denotes demonstrated
T9975 459-460 -LRB- denotes (
T9976 460-469 NNP denotes Jorritsma
T9977 470-472 FW denotes et
T9978 473-476 FW denotes al.
T9979 476-477 , denotes ,
T9980 478-482 CD denotes 2003
T9981 482-483 -RRB- denotes )
T9982 484-487 CC denotes but
T9983 488-492 RB denotes also
T9984 493-495 IN denotes in
T9985 496-499 CD denotes CD4
T9986 499-500 CD denotes +
T9987 501-502 NNP denotes T
T9988 503-508 NNS denotes cells
T9989 509-521 VBD denotes restimulated
T9990 522-526 IN denotes with
T9991 527-530 DT denotes the
T9992 531-535 JJ denotes same
T9993 536-540 JJ denotes high
T9994 541-544 CC denotes and
T9995 545-548 JJ denotes low
T9996 549-556 NN denotes antigen
T9997 557-562 NNS denotes doses
T9998 563-564 -LRB- denotes (
T9999 564-570 NN denotes Figure
T10000 571-573 NN denotes 5A
T10001 573-574 -RRB- denotes )
T10002 574-575 . denotes .
T10003 576-584 IN denotes Although
T10004 585-588 DT denotes the
T10005 589-597 JJ denotes apparent
T10006 598-602 NN denotes peak
T10007 603-606 CC denotes and
T10008 607-613 NN denotes amount
T10009 614-616 IN denotes of
T10010 617-621 CD denotes ERK1
T10011 622-625 CC denotes and
T10012 626-630 CD denotes ERK2
T10013 631-641 NN denotes activation
T10014 642-648 VBD denotes varied
T10015 649-657 RB denotes slightly
T10016 658-665 IN denotes between
T10017 666-677 NNS denotes experiments
T10018 677-678 , denotes ,
T10019 679-680 DT denotes a
T10020 681-691 JJ denotes consistent
T10021 692-699 NN denotes finding
T10022 700-703 VBD denotes was
T10023 704-708 DT denotes that
T10024 709-713 JJ denotes high
T10025 714-721 NN denotes antigen
T10026 722-726 NN denotes dose
T10027 727-741 VBD denotes differentiated
T10028 742-745 CD denotes Th1
T10029 746-751 NNS denotes cells
T10030 752-758 RB denotes always
T10031 759-765 VBD denotes showed
T10032 766-774 JJ denotes enhanced
T10033 775-778 CC denotes and
T10034 779-788 JJ denotes prolonged
T10035 789-793 CD denotes ERK1
T10036 794-797 CC denotes and
T10037 798-802 CD denotes ERK2
T10038 803-813 NN denotes activation
T10039 814-816 IN denotes in
T10040 817-820 DT denotes the
T10041 821-829 NN denotes presence
T10042 830-832 IN denotes of
T10043 833-838 NN denotes IL-12
T10044 838-839 , denotes ,
T10045 840-850 RB denotes regardless
T10046 851-853 IN denotes of
T10047 854-861 IN denotes whether
T10048 862-866 PRP denotes they
T10049 867-871 VBD denotes were
T10050 872-884 VBN denotes restimulated
T10051 885-889 IN denotes with
T10052 890-894 JJ denotes high
T10053 895-897 CC denotes or
T10054 898-901 JJ denotes low
T10055 902-909 NN denotes antigen
T10056 910-914 NN denotes dose
T10057 915-916 -LRB- denotes (
T10058 916-922 NN denotes Figure
T10059 923-925 NN denotes 5B
T10060 925-926 -RRB- denotes )
T10061 926-927 . denotes .
T10062 928-930 PRP denotes We
T10063 931-935 RB denotes then
T10064 936-948 VBD denotes investigated
T10065 949-956 IN denotes whether
T10066 957-961 NNP denotes ERK1
T10067 962-965 CC denotes and
T10068 966-970 NNP denotes ERK2
T10069 971-981 NN denotes activation
T10070 982-985 VBD denotes was
T10071 986-994 VBN denotes required
T10072 995-998 IN denotes for
T10073 999-1002 DT denotes the
T10074 1003-1012 NN denotes induction
T10075 1013-1015 IN denotes of
T10076 1016-1021 NNP denotes IL-10
T10077 1022-1024 IN denotes in
T10078 1025-1028 NNP denotes Th1
T10079 1029-1034 NNS denotes cells
T10080 1035-1037 IN denotes by
T10081 1038-1043 VBG denotes using
T10082 1044-1049 NNP denotes U0126
T10083 1050-1051 -LRB- denotes (
T10084 1051-1057 NNP denotes Figure
T10085 1058-1060 NNP denotes 5C
T10086 1060-1061 -RRB- denotes )
T10087 1061-1062 , denotes ,
T10088 1063-1064 DT denotes a
T10089 1065-1073 NN denotes compound
T10090 1074-1078 WDT denotes that
T10091 1079-1085 VBZ denotes blocks
T10092 1086-1096 JJ denotes downstream
T10093 1097-1100 NNP denotes ERK
T10094 1101-1111 NN denotes activation
T10095 1111-1112 . denotes .
T10096 1113-1115 TO denotes To
T10097 1116-1122 VB denotes ensure
T10098 1123-1127 IN denotes that
T10099 1128-1132 RB denotes only
T10100 1133-1134 NNP denotes T
T10101 1135-1139 NN denotes cell
T10102 1140-1149 VBG denotes signaling
T10103 1150-1153 VBD denotes was
T10104 1154-1159 VBG denotes being
T10105 1160-1168 VBN denotes affected
T10106 1169-1171 IN denotes by
T10107 1172-1177 NNP denotes U0126
T10108 1177-1178 , denotes ,
T10109 1179-1181 PRP denotes we
T10110 1182-1186 VBD denotes used
T10111 1187-1189 DT denotes an
T10112 1190-1198 JJ denotes APC-free
T10113 1199-1205 NN denotes system
T10114 1206-1208 IN denotes in
T10115 1209-1214 WDT denotes which
T10116 1215-1218 DT denotes the
T10117 1219-1220 NNP denotes T
T10118 1221-1226 NNS denotes cells
T10119 1227-1231 VBD denotes were
T10120 1232-1246 VBN denotes differentiated
T10121 1247-1249 IN denotes in
T10122 1250-1253 DT denotes the
T10123 1254-1262 NN denotes presence
T10124 1263-1265 IN denotes of
T10125 1266-1276 VBG denotes increasing
T10126 1277-1282 NNS denotes doses
T10127 1283-1285 IN denotes of
T10128 1286-1294 JJ denotes anti-CD3
T10129 1295-1298 CC denotes and
T10130 1299-1300 DT denotes a
T10131 1301-1309 JJ denotes constant
T10132 1310-1316 NN denotes amount
T10133 1317-1319 IN denotes of
T10134 1320-1325 NN denotes IL-12
T10135 1325-1326 . denotes .
T10136 1327-1329 IN denotes As
T10137 1330-1332 IN denotes in
T10138 1333-1336 DT denotes the
T10139 1337-1347 JJ denotes APC-driven
T10140 1348-1356 NNS denotes cultures
T10141 1356-1357 , denotes ,
T10142 1358-1366 JJR denotes stronger
T10143 1367-1370 NNP denotes TCR
T10144 1371-1382 NN denotes stimulation
T10145 1383-1391 RB denotes together
T10146 1392-1396 IN denotes with
T10147 1397-1402 NNP denotes IL-12
T10148 1403-1406 VBD denotes led
T10149 1407-1409 TO denotes to
T10150 1410-1416 JJR denotes higher
T10151 1417-1428 NNS denotes percentages
T10152 1429-1431 IN denotes of
T10153 1432-1437 NNS denotes cells
T10154 1438-1447 VBG denotes producing
T10155 1448-1452 DT denotes both
T10156 1453-1458 NNP denotes IL-10
T10157 1459-1462 CC denotes and
T10158 1463-1468 NNP denotes IFN-γ
T10159 1469-1474 IN denotes after
T10160 1475-1476 CD denotes 1
T10161 1477-1481 NN denotes week
T10162 1482-1484 IN denotes of
T10163 1485-1492 NN denotes culture
T10164 1493-1494 -LRB- denotes (
T10165 1494-1500 NN denotes Figure
T10166 1501-1503 NN denotes 5C
T10167 1503-1504 -RRB- denotes )
T10168 1504-1505 . denotes .
T10169 1506-1514 NN denotes Addition
T10170 1515-1517 IN denotes of
T10171 1518-1523 CD denotes U0126
T10172 1524-1526 TO denotes to
T10173 1527-1530 DT denotes the
T10174 1531-1539 NNS denotes cultures
T10175 1540-1549 VBD denotes abrogated
T10176 1550-1553 DT denotes the
T10177 1554-1564 NN denotes production
T10178 1565-1567 IN denotes of
T10179 1568-1573 NN denotes IL-10
T10180 1574-1576 IN denotes at
T10181 1577-1580 DT denotes all
T10182 1581-1586 NNS denotes doses
T10183 1587-1589 IN denotes of
T10184 1590-1598 JJ denotes anti-CD3
T10185 1599-1600 -LRB- denotes (
T10186 1600-1606 NN denotes Figure
T10187 1607-1609 NN denotes 5C
T10188 1609-1610 -RRB- denotes )
T10189 1610-1611 . denotes .
T10190 1612-1619 IN denotes Because
T10191 1620-1625 NNP denotes U0126
T10192 1626-1634 VBZ denotes inhibits
T10193 1635-1638 DT denotes the
T10194 1639-1653 JJ denotes MEK5-catalyzed
T10195 1654-1664 NN denotes activation
T10196 1665-1667 IN denotes of
T10197 1668-1672 CD denotes ERK5
T10198 1672-1673 , denotes ,
T10199 1674-1676 RB denotes as
T10200 1677-1681 RB denotes well
T10201 1682-1684 IN denotes as
T10202 1685-1688 DT denotes the
T10203 1689-1693 NNP denotes MEK1
T10204 1693-1694 : denotes -
T10205 1695-1698 CC denotes and
T10206 1699-1713 JJ denotes MEK2-catalyzed
T10207 1714-1724 NN denotes activation
T10208 1725-1727 IN denotes of
T10209 1728-1732 CD denotes ERK1
T10210 1733-1736 CC denotes and
T10211 1737-1741 CD denotes ERK2
T10212 1742-1743 -LRB- denotes (
T10213 1743-1747 NNP denotes Bain
T10214 1748-1750 FW denotes et
T10215 1751-1754 FW denotes al.
T10216 1754-1755 , denotes ,
T10217 1756-1760 CD denotes 2007
T10218 1760-1761 : denotes ;
T10219 1762-1766 NNP denotes Mody
T10220 1767-1769 FW denotes et
T10221 1770-1773 FW denotes al.
T10222 1773-1774 , denotes ,
T10223 1775-1779 CD denotes 2001
T10224 1779-1780 -RRB- denotes )
T10225 1780-1781 , denotes ,
T10226 1782-1784 PRP denotes we
T10227 1785-1789 RB denotes also
T10228 1790-1794 VBD denotes used
T10229 1795-1798 DT denotes the
T10230 1799-1803 RBR denotes more
T10231 1804-1812 JJ denotes specific
T10232 1812-1813 , denotes ,
T10233 1814-1826 RB denotes structurally
T10234 1827-1836 JJ denotes unrelated
T10235 1837-1841 NNP denotes MEK1
T10236 1842-1845 CC denotes and
T10237 1846-1850 NNP denotes MEK2
T10238 1851-1860 NN denotes inhibitor
T10239 1861-1869 NNP denotes PD184352
T10240 1870-1872 IN denotes at
T10241 1873-1887 NNS denotes concentrations
T10242 1888-1890 IN denotes in
T10243 1891-1896 WDT denotes which
T10244 1897-1899 PRP denotes it
T10245 1900-1908 VBZ denotes inhibits
T10246 1909-1913 NNP denotes MEK1
T10247 1914-1917 CC denotes and
T10248 1918-1922 NNP denotes MEK2
T10249 1923-1926 CC denotes but
T10250 1927-1930 RB denotes not
T10251 1931-1935 NNP denotes MEK5
T10252 1936-1937 -LRB- denotes (
T10253 1937-1941 NNP denotes Bain
T10254 1942-1944 FW denotes et
T10255 1945-1948 FW denotes al.
T10256 1948-1949 , denotes ,
T10257 1950-1954 CD denotes 2007
T10258 1954-1955 : denotes ;
T10259 1956-1960 NNP denotes Mody
T10260 1961-1963 FW denotes et
T10261 1964-1967 FW denotes al.
T10262 1967-1968 , denotes ,
T10263 1969-1973 CD denotes 2001
T10264 1973-1974 -RRB- denotes )
T10265 1974-1975 . denotes .
T10266 1976-1984 CD denotes PD184352
T10267 1985-1991 VBD denotes caused
T10268 1992-1993 DT denotes a
T10269 1994-2001 JJ denotes similar
T10270 2002-2012 NN denotes inhibition
T10271 2013-2015 IN denotes of
T10272 2016-2021 JJ denotes IL-10
T10273 2022-2032 NN denotes production
T10274 2033-2035 IN denotes by
T10275 2036-2039 JJ denotes Th1
T10276 2040-2045 NNS denotes cells
T10277 2046-2048 IN denotes in
T10278 2049-2050 DT denotes a
T10279 2051-2065 JJ denotes dose-dependent
T10280 2066-2073 NN denotes fashion
T10281 2074-2075 -LRB- denotes (
T10282 2075-2081 NN denotes Figure
T10283 2082-2084 CD denotes 5D
T10284 2085-2088 CC denotes and
T10285 2089-2095 NNP denotes Figure
T10286 2096-2099 NNP denotes S5A
T10287 2099-2100 -RRB- denotes )
T10288 2100-2101 . denotes .
T10289 2102-2106 IN denotes Upon
T10290 2107-2115 NN denotes addition
T10291 2116-2118 IN denotes of
T10292 2119-2129 NNS denotes inhibitors
T10293 2130-2132 TO denotes to
T10294 2133-2138 JJ denotes other
T10295 2139-2148 VBG denotes signaling
T10296 2149-2157 NNS denotes pathways
T10297 2157-2158 , denotes ,
T10298 2159-2168 VBG denotes including
T10299 2169-2170 DT denotes a
T10300 2171-2174 JJ denotes p38
T10301 2175-2179 NNP denotes MAPK
T10302 2180-2189 NN denotes inhibitor
T10303 2189-2190 , denotes ,
T10304 2191-2199 NNP denotes SB203580
T10305 2199-2200 , denotes ,
T10306 2201-2203 CC denotes or
T10307 2204-2207 DT denotes the
T10308 2208-2213 NNP denotes GSK3β
T10309 2214-2223 NN denotes inhibitor
T10310 2223-2224 , denotes ,
T10311 2225-2232 NNP denotes CT99021
T10312 2233-2234 -LRB- denotes (
T10313 2234-2238 NNP denotes Bain
T10314 2239-2241 FW denotes et
T10315 2242-2245 FW denotes al.
T10316 2245-2246 , denotes ,
T10317 2247-2251 CD denotes 2007
T10318 2251-2252 -RRB- denotes )
T10319 2252-2253 , denotes ,
T10320 2254-2256 DT denotes no
T10321 2257-2263 NN denotes effect
T10322 2264-2266 IN denotes on
T10323 2267-2272 NN denotes IL-10
T10324 2273-2283 NN denotes production
T10325 2284-2287 VBD denotes was
T10326 2288-2296 VBN denotes observed
T10327 2297-2298 -LRB- denotes (
T10328 2298-2304 NN denotes Figure
T10329 2305-2308 CD denotes S5B
T10330 2308-2309 -RRB- denotes )
T10331 2309-2310 . denotes .
T10332 2311-2314 PRP$ denotes Our
T10333 2315-2319 NNS denotes data
T10334 2320-2324 RB denotes thus
T10335 2325-2334 VBD denotes suggested
T10336 2335-2339 IN denotes that
T10337 2340-2345 JJ denotes IL-10
T10338 2346-2356 NN denotes production
T10339 2357-2359 IN denotes by
T10340 2360-2363 JJ denotes Th1
T10341 2364-2369 NNS denotes cells
T10342 2370-2372 IN denotes in
T10343 2373-2381 NN denotes response
T10344 2382-2384 TO denotes to
T10345 2385-2389 JJ denotes high
T10346 2390-2397 NN denotes antigen
T10347 2398-2402 NN denotes dose
T10348 2403-2406 CC denotes and
T10349 2407-2412 NN denotes IL-12
T10350 2413-2421 VBZ denotes requires
T10351 2422-2426 CD denotes ERK1
T10352 2427-2430 CC denotes and
T10353 2431-2435 CD denotes ERK2
T10354 2436-2445 VBG denotes signaling
T10355 2445-2446 , denotes ,
T10356 2447-2450 CC denotes but
T10357 2451-2454 RB denotes not
T10358 2455-2458 DT denotes the
T10359 2459-2469 NN denotes activation
T10360 2470-2472 IN denotes of
T10361 2473-2476 DT denotes the
T10362 2477-2480 CD denotes p38
T10363 2481-2483 CC denotes or
T10364 2484-2487 DT denotes the
T10365 2488-2493 NNP denotes GSK3β
T10366 2494-2502 NNS denotes pathways
T10367 2502-2503 . denotes .
R7613 T9893 T9894 compound IL-10,Production
R7614 T9894 T9898 nsubj Production,Requires
R7615 T9895 T9894 prep by,Production
R7616 T9896 T9897 compound Th1,Cells
R7617 T9897 T9895 pobj Cells,by
R7618 T9898 T9898 ROOT Requires,Requires
R7619 T9899 T9898 dobj ERK1,Requires
R7620 T9900 T9899 cc and,ERK1
R7621 T9901 T9899 conj ERK2,ERK1
R7622 T9902 T9905 nsubj Activation,showed
R7623 T9903 T9904 poss Our,data
R7624 T9904 T9905 nsubj data,showed
R7625 T9905 T9905 ROOT showed,showed
R7626 T9906 T9915 mark that,required
R7627 T9907 T9908 det the,maintenance
R7628 T9908 T9915 nsubj maintenance,required
R7629 T9909 T9908 prep of,maintenance
R7630 T9910 T9911 compound IL-10,induction
R7631 T9911 T9909 pobj induction,of
R7632 T9912 T9911 prep in,induction
R7633 T9913 T9914 amod Th1,cells
R7634 T9914 T9912 pobj cells,in
R7635 T9915 T9905 ccomp required,showed
R7636 T9916 T9915 dobj stimulation,required
R7637 T9917 T9916 prep with,stimulation
R7638 T9918 T9920 amod high,dose
R7639 T9919 T9920 compound antigen,dose
R7640 T9920 T9917 pobj dose,with
R7641 T9921 T9920 punct ",",dose
R7642 T9922 T9928 dobj which,compensated
R7643 T9923 T9928 prep to,compensated
R7644 T9924 T9925 det some,extent
R7645 T9925 T9928 nsubjpass extent,compensated
R7646 T9926 T9928 aux could,compensated
R7647 T9927 T9928 auxpass be,compensated
R7648 T9928 T9920 relcl compensated,dose
R7649 T9929 T9928 prep for,compensated
R7650 T9930 T9928 agent by,compensated
R7651 T9931 T9932 det the,addition
R7652 T9932 T9930 pobj addition,by
R7653 T9933 T9932 prep of,addition
R7654 T9934 T9933 pobj IL-12,of
R7655 T9935 T9905 punct .,showed
R7656 T9936 T9945 nsubj Signaling,induced
R7657 T9937 T9936 prep through,Signaling
R7658 T9938 T9939 det the,TCR
R7659 T9939 T9937 pobj TCR,through
R7660 T9940 T9936 prep with,Signaling
R7661 T9941 T9942 amod high,doses
R7662 T9942 T9940 pobj doses,with
R7663 T9943 T9942 prep of,doses
R7664 T9944 T9943 pobj antigen,of
R7665 T9945 T9945 ROOT induced,induced
R7666 T9946 T9950 amod stronger,activation
R7667 T9947 T9950 nsubj ERK1,activation
R7668 T9948 T9947 cc and,ERK1
R7669 T9949 T9947 conj ERK2,ERK1
R7670 T9950 T9945 dobj activation,induced
R7671 T9951 T9950 prep than,activation
R7672 T9952 T9951 pobj that,than
R7673 T9953 T9952 acl induced,that
R7674 T9954 T9953 agent by,induced
R7675 T9955 T9957 amod low,dose
R7676 T9956 T9957 compound antigen,dose
R7677 T9957 T9954 pobj dose,by
R7678 T9958 T9957 punct ",",dose
R7679 T9959 T9961 preconj not,in
R7680 T9960 T9959 advmod only,not
R7681 T9961 T9953 prep in,induced
R7682 T9962 T9966 amod naive,cells
R7683 T9963 T9966 nmod CD4,cells
R7684 T9964 T9966 nummod +,cells
R7685 T9965 T9966 compound T,cells
R7686 T9966 T9961 pobj cells,in
R7687 T9967 T9966 punct (,cells
R7688 T9968 T9978 nmod data,al.
R7689 T9969 T9970 neg not,shown
R7690 T9970 T9968 acl shown,data
R7691 T9971 T9970 punct ),shown
R7692 T9972 T9974 mark as,demonstrated
R7693 T9973 T9974 advmod previously,demonstrated
R7694 T9974 T9968 advcl demonstrated,data
R7695 T9975 T9978 punct (,al.
R7696 T9976 T9978 nmod Jorritsma,al.
R7697 T9977 T9978 nmod et,al.
R7698 T9978 T9966 appos al.,cells
R7699 T9979 T9978 punct ",",al.
R7700 T9980 T9978 npadvmod 2003,al.
R7701 T9981 T9978 punct ),al.
R7702 T9982 T9978 cc but,al.
R7703 T9983 T9982 advmod also,but
R7704 T9984 T9989 prep in,restimulated
R7705 T9985 T9988 nummod CD4,cells
R7706 T9986 T9988 nummod +,cells
R7707 T9987 T9988 compound T,cells
R7708 T9988 T9984 pobj cells,in
R7709 T9989 T9978 conj restimulated,al.
R7710 T9990 T9989 prep with,restimulated
R7711 T9991 T9997 det the,doses
R7712 T9992 T9997 amod same,doses
R7713 T9993 T9996 amod high,antigen
R7714 T9994 T9993 cc and,high
R7715 T9995 T9993 conj low,high
R7744 T10024 T10025 amod high,antigen
R7745 T10025 T10026 compound antigen,dose
R7746 T10026 T10027 nsubj dose,differentiated
R7747 T10027 T10022 conj differentiated,was
R7748 T10028 T10029 nummod Th1,cells
R7749 T10029 T10027 dobj cells,differentiated
R7750 T10030 T10031 advmod always,showed
R7751 T10031 T10027 conj showed,differentiated
R7752 T10032 T10035 amod enhanced,ERK1
R7753 T10033 T10032 cc and,enhanced
R7754 T10034 T10032 conj prolonged,enhanced
R7755 T10035 T10031 dobj ERK1,showed
R7756 T10036 T10035 cc and,ERK1
R7757 T10037 T10038 nummod ERK2,activation
R7758 T10038 T10035 conj activation,ERK1
R7759 T10039 T10038 prep in,activation
R7760 T10040 T10041 det the,presence
R7761 T10041 T10039 pobj presence,in
R7762 T10042 T10041 prep of,presence
R7763 T10043 T10042 pobj IL-12,of
R7764 T10044 T10027 punct ",",differentiated
R7765 T10045 T10027 advmod regardless,differentiated
R7766 T10046 T10045 prep of,regardless
R7767 T10047 T10050 mark whether,restimulated
R7768 T10048 T10050 nsubjpass they,restimulated
R7769 T10049 T10050 auxpass were,restimulated
R7770 T10050 T10046 pcomp restimulated,of
R7771 T10051 T10050 prep with,restimulated
R7772 T10052 T10056 amod high,dose
R7773 T10053 T10052 cc or,high
R7774 T10054 T10052 conj low,high
R7775 T10055 T10056 compound antigen,dose
R7776 T10056 T10051 pobj dose,with
R7777 T10057 T10056 punct (,dose
R7778 T10058 T10059 compound Figure,5B
R7779 T10059 T10056 appos 5B,dose
R7780 T10060 T10056 punct ),dose
R7781 T10061 T10027 punct .,differentiated
R7782 T10062 T10064 nsubj We,investigated
R7783 T10063 T10064 advmod then,investigated
R7784 T10064 T10064 ROOT investigated,investigated
R7785 T10065 T10071 mark whether,required
R7786 T10066 T10069 nmod ERK1,activation
R7787 T10067 T10066 cc and,ERK1
R7788 T10068 T10066 conj ERK2,ERK1
R7789 T10069 T10071 nsubjpass activation,required
R7790 T10070 T10071 auxpass was,required
R7791 T10071 T10064 ccomp required,investigated
R7792 T10072 T10071 prep for,required
R7793 T10073 T10074 det the,induction
R7794 T10074 T10072 pobj induction,for
R7795 T10075 T10074 prep of,induction
R7796 T10076 T10075 pobj IL-10,of
R7797 T10077 T10074 prep in,induction
R7798 T10078 T10079 compound Th1,cells
R7799 T10079 T10077 pobj cells,in
R7800 T10080 T10071 prep by,required
R7801 T10081 T10080 pcomp using,by
R7802 T10082 T10081 dobj U0126,using
R7803 T10083 T10085 punct (,5C
R7804 T10084 T10085 compound Figure,5C
R7805 T10085 T10082 appos 5C,U0126
R7806 T10086 T10085 punct ),5C
R7807 T10087 T10082 punct ",",U0126
R7808 T10088 T10089 det a,compound
R7809 T10089 T10082 appos compound,U0126
R7810 T10090 T10091 nsubj that,blocks
R7811 T10091 T10089 relcl blocks,compound
R7812 T10092 T10094 amod downstream,activation
R7813 T10093 T10094 compound ERK,activation
R7814 T10094 T10091 dobj activation,blocks
R7815 T10095 T10064 punct .,investigated
R7816 T10096 T10097 aux To,ensure
R7817 T10097 T10110 advcl ensure,used
R7818 T10098 T10105 mark that,affected
R7819 T10099 T10102 advmod only,signaling
R7820 T10100 T10101 compound T,cell
R7821 T10101 T10102 compound cell,signaling
R7822 T10102 T10105 nsubjpass signaling,affected
R7823 T10103 T10105 aux was,affected
R7824 T10104 T10105 auxpass being,affected
R7825 T10105 T10097 ccomp affected,ensure
R7826 T10106 T10105 agent by,affected
R7827 T10107 T10106 pobj U0126,by
R7828 T10108 T10110 punct ",",used
R7829 T10109 T10110 nsubj we,used
R7830 T10110 T10110 ROOT used,used
R7831 T10111 T10113 det an,system
R7832 T10112 T10113 amod APC-free,system
R7833 T10113 T10110 dobj system,used
R7834 T10114 T10120 prep in,differentiated
R7835 T10115 T10114 pobj which,in
R7836 T10116 T10118 det the,cells
R7837 T10117 T10118 compound T,cells
R7838 T10118 T10120 nsubjpass cells,differentiated
R7839 T10119 T10120 auxpass were,differentiated
R7840 T10120 T10113 relcl differentiated,system
R7841 T10121 T10120 prep in,differentiated
R7842 T10122 T10123 det the,presence
R7843 T10123 T10121 pobj presence,in
R7864 T10144 T10140 appos stimulation,cultures
R7865 T10145 T10146 advmod together,with
R7866 T10146 T10148 nsubj with,led
R7867 T10147 T10146 pobj IL-12,with
R7868 T10148 T10148 ROOT led,led
R7869 T10149 T10148 prep to,led
R7870 T10150 T10151 amod higher,percentages
R7871 T10151 T10149 pobj percentages,to
R7872 T10152 T10151 prep of,percentages
R7873 T10153 T10152 pobj cells,of
R7874 T10154 T10153 acl producing,cells
R7875 T10155 T10156 preconj both,IL-10
R7876 T10156 T10154 dobj IL-10,producing
R7877 T10157 T10156 cc and,IL-10
R7878 T10158 T10156 conj IFN-γ,IL-10
R7879 T10159 T10148 prep after,led
R7880 T10160 T10161 nummod 1,week
R7881 T10161 T10159 pobj week,after
R7882 T10162 T10161 prep of,week
R7883 T10163 T10162 pobj culture,of
R7884 T10164 T10166 punct (,5C
R7885 T10165 T10166 compound Figure,5C
R7886 T10166 T10163 appos 5C,culture
R7887 T10167 T10148 punct ),led
R7888 T10168 T10148 punct .,led
R7889 T10169 T10175 nsubj Addition,abrogated
R7890 T10170 T10169 prep of,Addition
R7891 T10171 T10170 pobj U0126,of
R7892 T10172 T10169 prep to,Addition
R7893 T10173 T10174 det the,cultures
R7894 T10174 T10172 pobj cultures,to
R7895 T10175 T10175 ROOT abrogated,abrogated
R7896 T10176 T10177 det the,production
R7897 T10177 T10175 dobj production,abrogated
R7898 T10178 T10177 prep of,production
R7899 T10179 T10178 pobj IL-10,of
R7900 T10180 T10175 prep at,abrogated
R7901 T10181 T10182 det all,doses
R7902 T10182 T10180 pobj doses,at
R7903 T10183 T10182 prep of,doses
R7904 T10184 T10183 pobj anti-CD3,of
R7905 T10185 T10187 punct (,5C
R7906 T10186 T10187 compound Figure,5C
R7907 T10187 T10184 appos 5C,anti-CD3
R7908 T10188 T10184 punct ),anti-CD3
R7909 T10189 T10175 punct .,abrogated
R7910 T10190 T10192 mark Because,inhibits
R7911 T10191 T10192 nsubj U0126,inhibits
R7912 T10192 T10192 ROOT inhibits,inhibits
R7913 T10193 T10195 det the,activation
R7914 T10194 T10195 amod MEK5-catalyzed,activation
R7915 T10195 T10192 dobj activation,inhibits
R7916 T10196 T10195 prep of,activation
R7917 T10197 T10196 pobj ERK5,of
R7918 T10198 T10192 punct ",",inhibits
R7919 T10199 T10201 advmod as,as
R7920 T10200 T10201 advmod well,as
R7921 T10201 T10192 cc as,inhibits
R7922 T10202 T10203 det the,MEK1
R7923 T10203 T10192 dobj MEK1,inhibits
R7924 T10204 T10203 punct -,MEK1
R7925 T10205 T10203 cc and,MEK1
R7926 T10206 T10207 amod MEK2-catalyzed,activation
R7927 T10207 T10203 conj activation,MEK1
R7928 T10208 T10207 prep of,activation
R7929 T10209 T10208 pobj ERK1,of
R7930 T10210 T10209 cc and,ERK1
R7931 T10211 T10209 conj ERK2,ERK1
R7932 T10212 T10228 punct (,used
R7933 T10213 T10215 compound Bain,al.
R7934 T10214 T10215 nmod et,al.
R7935 T10215 T10228 ccomp al.,used
R7936 T10216 T10215 punct ",",al.
R7937 T10217 T10215 npadvmod 2007,al.
R7938 T10218 T10228 punct ;,used
R7939 T10219 T10221 compound Mody,al.
R7940 T10220 T10221 compound et,al.
R7941 T10221 T10228 npadvmod al.,used
R7942 T10222 T10221 punct ",",al.
R7943 T10223 T10221 npadvmod 2001,al.
R7944 T10224 T10221 punct ),al.
R7945 T10225 T10228 punct ",",used
R7946 T10226 T10228 nsubj we,used
R7947 T10227 T10228 advmod also,used
R7948 T10228 T10228 ROOT used,used
R7949 T10229 T10235 det the,MEK1
R7950 T10230 T10231 advmod more,specific
R7951 T10231 T10235 amod specific,MEK1
R7952 T10232 T10235 punct ",",MEK1
R7953 T10233 T10234 advmod structurally,unrelated
R7954 T10234 T10235 amod unrelated,MEK1
R7955 T10235 T10228 dobj MEK1,used
R7956 T10236 T10235 cc and,MEK1
R7957 T10237 T10238 compound MEK2,inhibitor
R7958 T10238 T10239 compound inhibitor,PD184352
R7959 T10239 T10235 conj PD184352,MEK1
R7960 T10240 T10228 prep at,used
R7961 T10241 T10240 pobj concentrations,at
R7962 T10242 T10245 prep in,inhibits
R7963 T10243 T10242 pobj which,in
R7964 T10244 T10245 nsubj it,inhibits
R7965 T10245 T10245 ROOT inhibits,inhibits
R7966 T10246 T10245 dobj MEK1,inhibits
R7967 T10247 T10246 cc and,MEK1
R7968 T10248 T10246 conj MEK2,MEK1
R7969 T10249 T10248 cc but,MEK2
R7970 T10250 T10261 neg not,al.
R7971 T10251 T10261 nmod MEK5,al.
R7972 T10252 T10261 punct (,al.
R7973 T10253 T10255 compound Bain,al.
R7974 T10254 T10255 nmod et,al.
R7975 T10255 T10261 ccomp al.,al.
R7976 T10256 T10255 punct ",",al.
R7977 T10257 T10255 npadvmod 2007,al.
R7978 T10258 T10261 punct ;,al.
R7979 T10259 T10261 compound Mody,al.
R7980 T10260 T10261 nmod et,al.
R7981 T10261 T10248 conj al.,MEK2
R7982 T10262 T10261 punct ",",al.
R7983 T10263 T10261 npadvmod 2001,al.
R7984 T10264 T10261 punct ),al.
R7985 T10265 T10228 punct .,used
R7986 T10266 T10267 nsubj PD184352,caused
R7987 T10267 T10267 ROOT caused,caused
R7988 T10268 T10270 det a,inhibition
R7989 T10269 T10270 amod similar,inhibition
R7990 T10270 T10267 dobj inhibition,caused
R7991 T10271 T10270 prep of,inhibition
R7992 T10272 T10273 amod IL-10,production
R7993 T10273 T10271 pobj production,of
R7994 T10274 T10273 prep by,production
R7995 T10275 T10276 amod Th1,cells
R7996 T10276 T10274 pobj cells,by
R7997 T10277 T10267 prep in,caused
R7998 T10278 T10280 det a,fashion
R7999 T10279 T10280 amod dose-dependent,fashion
R8000 T10280 T10277 pobj fashion,in
R8001 T10281 T10282 punct (,Figure
R8002 T10282 T10280 appos Figure,fashion
R8003 T10283 T10282 nummod 5D,Figure
R8004 T10284 T10282 cc and,Figure
R8005 T10285 T10286 compound Figure,S5A
R8006 T10286 T10282 conj S5A,Figure
R8007 T10287 T10267 punct ),caused
R8008 T10288 T10267 punct .,caused
R8009 T10289 T10326 prep Upon,observed
R8010 T10290 T10289 pobj addition,Upon
R8011 T10291 T10290 prep of,addition
R8012 T10292 T10291 pobj inhibitors,of
R8013 T10293 T10290 prep to,addition
R8014 T10294 T10296 amod other,pathways
R8015 T10295 T10296 amod signaling,pathways
R8016 T10296 T10293 pobj pathways,to
R8017 T10297 T10296 punct ",",pathways
R8018 T10298 T10296 prep including,pathways
R8019 T10299 T10302 det a,inhibitor
R8020 T10300 T10302 amod p38,inhibitor
R8021 T10301 T10302 compound MAPK,inhibitor
R8022 T10302 T10298 pobj inhibitor,including
R8023 T10303 T10302 punct ",",inhibitor
R8024 T10304 T10302 appos SB203580,inhibitor
R8025 T10305 T10304 punct ",",SB203580
R8026 T10306 T10304 cc or,SB203580
R8027 T10307 T10309 det the,inhibitor
R8028 T10308 T10309 compound GSK3β,inhibitor
R8029 T10309 T10304 conj inhibitor,SB203580
R8030 T10310 T10309 punct ",",inhibitor
R8070 T10350 T10335 ccomp requires,suggested
R8071 T10351 T10350 dobj ERK1,requires
R8072 T10352 T10351 cc and,ERK1
R8073 T10353 T10351 conj ERK2,ERK1
R8074 T10354 T10350 advcl signaling,requires
R8075 T10355 T10354 punct ",",signaling
R8076 T10356 T10354 cc but,signaling
R8077 T10357 T10359 neg not,activation
R8078 T10358 T10359 det the,activation
R8079 T10359 T10354 conj activation,signaling
R8080 T10360 T10359 prep of,activation
R8081 T10361 T10362 det the,p38
R8082 T10362 T10360 pobj p38,of
R8083 T10363 T10362 cc or,p38
R8084 T10364 T10366 det the,pathways
R8085 T10365 T10366 compound GSK3β,pathways
R8086 T10366 T10362 conj pathways,p38
R8087 T10367 T10335 punct .,suggested
R8031 T10311 T10309 appos CT99021,inhibitor
R8032 T10312 T10315 punct (,al.
R8033 T10313 T10315 compound Bain,al.
R8034 T10314 T10315 nmod et,al.
R7716 T9996 T9997 compound antigen,doses
R7717 T9997 T9990 pobj doses,with
R7718 T9998 T10000 punct (,5A
R7719 T9999 T10000 compound Figure,5A
R7720 T10000 T9997 appos 5A,doses
R7721 T10001 T10000 punct ),5A
R7722 T10002 T9945 punct .,induced
R7723 T10003 T10014 mark Although,varied
R7724 T10004 T10006 det the,peak
R7725 T10005 T10006 amod apparent,peak
R7726 T10006 T10014 nsubj peak,varied
R7727 T10007 T10006 cc and,peak
R7728 T10008 T10006 conj amount,peak
R7729 T10009 T10008 prep of,amount
R7730 T10010 T10009 pobj ERK1,of
R7731 T10011 T10010 cc and,ERK1
R7732 T10012 T10010 conj ERK2,ERK1
R7733 T10013 T10008 conj activation,amount
R7734 T10014 T10022 advcl varied,was
R7735 T10015 T10014 advmod slightly,varied
R7736 T10016 T10014 prep between,varied
R7737 T10017 T10016 pobj experiments,between
R7738 T10018 T10022 punct ",",was
R7739 T10019 T10021 det a,finding
R7740 T10020 T10021 amod consistent,finding
R7741 T10021 T10022 nsubj finding,was
R7742 T10022 T10022 ROOT was,was
R7743 T10023 T10026 det that,dose
R7844 T10124 T10123 prep of,presence
R7845 T10125 T10126 amod increasing,doses
R7846 T10126 T10124 pobj doses,of
R7847 T10127 T10126 prep of,doses
R7848 T10128 T10127 pobj anti-CD3,of
R7849 T10129 T10128 cc and,anti-CD3
R7850 T10130 T10132 det a,amount
R7851 T10131 T10132 amod constant,amount
R7852 T10132 T10128 conj amount,anti-CD3
R7853 T10133 T10132 prep of,amount
R7854 T10134 T10133 pobj IL-12,of
R7855 T10135 T10110 punct .,used
R7856 T10136 T10148 prep As,led
R7857 T10137 T10136 prep in,As
R7858 T10138 T10140 det the,cultures
R7859 T10139 T10140 amod APC-driven,cultures
R7860 T10140 T10137 pobj cultures,in
R7861 T10141 T10140 punct ",",cultures
R7862 T10142 T10144 amod stronger,stimulation
R7863 T10143 T10144 compound TCR,stimulation
R8035 T10315 T10309 parataxis al.,inhibitor
R8036 T10316 T10315 punct ",",al.
R8037 T10317 T10315 npadvmod 2007,al.
R8038 T10318 T10315 punct ),al.
R8039 T10319 T10309 punct ",",inhibitor
R8040 T10320 T10321 det no,effect
R8041 T10321 T10326 nsubjpass effect,observed
R8042 T10322 T10321 prep on,effect
R8043 T10323 T10324 compound IL-10,production
R8044 T10324 T10322 pobj production,on
R8045 T10325 T10326 auxpass was,observed
R8046 T10326 T10326 ROOT observed,observed
R8047 T10327 T10328 punct (,Figure
R8048 T10328 T10326 oprd Figure,observed
R8049 T10329 T10328 nummod S5B,Figure
R8050 T10330 T10328 punct ),Figure
R8051 T10331 T10326 punct .,observed
R8052 T10332 T10333 poss Our,data
R8053 T10333 T10335 nsubj data,suggested
R8054 T10334 T10335 advmod thus,suggested
R8055 T10335 T10335 ROOT suggested,suggested
R8056 T10336 T10350 mark that,requires
R8057 T10337 T10338 amod IL-10,production
R8058 T10338 T10350 nsubj production,requires
R8059 T10339 T10338 prep by,production
R8060 T10340 T10341 amod Th1,cells
R8061 T10341 T10339 pobj cells,by
R8062 T10342 T10338 prep in,production
R8063 T10343 T10342 pobj response,in
R8064 T10344 T10343 prep to,response
R8065 T10345 T10347 amod high,dose
R8066 T10346 T10347 compound antigen,dose
R8067 T10347 T10344 pobj dose,to
R8068 T10348 T10347 cc and,dose
R8069 T10349 T10350 nsubj IL-12,requires

GO-BP

Id Subject Object Predicate Lexical cue
T10380 0-16 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 Production
T10381 1554-1573 http://purl.obolibrary.org/obo/GO_0032653 denotes production of IL-10
T10382 2016-2032 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T10383 2267-2283 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T10384 2340-2356 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T10385 0-16 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 Production
T10386 1554-1573 http://purl.obolibrary.org/obo/GO_0032613 denotes production of IL-10
T10387 2016-2032 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T10388 2267-2283 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T10389 2340-2356 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T10390 39-43 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10391 320-324 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10392 617-621 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10393 789-793 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10394 957-961 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10395 1728-1732 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10396 48-52 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10397 329-333 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10398 626-630 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10399 798-802 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10400 966-970 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10401 1737-1741 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10402 1097-1100 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK
T10403 2171-2174 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T10404 2175-2179 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10405 272-275 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T10406 1367-1370 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T10407 320-344 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T10408 617-641 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T10409 789-813 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T10410 957-981 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T10411 1140-1149 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T10412 2139-2148 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T10413 2436-2445 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T10414 1689-1693 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T10415 1837-1841 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T10416 1699-1703 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T10417 1846-1850 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T10418 1918-1922 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T10419 2139-2157 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T10420 2422-2445 http://purl.obolibrary.org/obo/GO_0070371 denotes ERK1 and ERK2 signaling

GO-MF

Id Subject Object Predicate Lexical cue
T10421 0-5 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10422 104-109 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10423 1016-1021 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10424 1453-1458 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10425 1568-1573 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10426 2016-2021 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10427 2267-2272 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10428 2340-2345 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10429 39-43 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10430 320-324 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10431 617-621 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10432 789-793 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10433 957-961 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10434 1728-1732 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10435 48-52 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10436 329-333 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10437 626-630 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10438 798-802 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10439 966-970 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10440 1737-1741 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10441 1097-1100 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK
T10442 2171-2174 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T10443 2175-2179 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10444 243-248 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T10445 833-838 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T10446 1320-1325 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T10447 1397-1402 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T10448 2407-2412 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T10449 1689-1693 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T10450 1837-1841 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T10451 1699-1703 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T10452 1846-1850 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T10453 1918-1922 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2

GO-CC

Id Subject Object Predicate Lexical cue
T10454 127-132 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10455 409-414 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10456 503-508 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10457 746-751 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10458 1029-1034 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10459 1221-1226 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10460 1432-1437 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10461 2040-2045 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10462 2364-2369 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10463 272-275 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T10464 1367-1370 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T10465 1190-1193 http://purl.obolibrary.org/obo/GO_0005680 denotes APC
T10466 1337-1340 http://purl.obolibrary.org/obo/GO_0005680 denotes APC

sentences

Id Subject Object Predicate Lexical cue
T9380 0-63 Sentence denotes IL-10 Production by Th1 Cells Requires ERK1 and ERK2 Activation
T9381 64-249 Sentence denotes Our data showed that the maintenance of IL-10 induction in Th1 cells required stimulation with high antigen dose, which to some extent could be compensated for by the addition of IL-12.
T9382 250-575 Sentence denotes Signaling through the TCR with high doses of antigen induced stronger ERK1 and ERK2 activation than that induced by low antigen dose, not only in naive CD4+ T cells (data not shown) as previously demonstrated (Jorritsma et al., 2003) but also in CD4+ T cells restimulated with the same high and low antigen doses (Figure 5A).
T9383 576-927 Sentence denotes Although the apparent peak and amount of ERK1 and ERK2 activation varied slightly between experiments, a consistent finding was that high antigen dose differentiated Th1 cells always showed enhanced and prolonged ERK1 and ERK2 activation in the presence of IL-12, regardless of whether they were restimulated with high or low antigen dose (Figure 5B).
T9384 928-1112 Sentence denotes We then investigated whether ERK1 and ERK2 activation was required for the induction of IL-10 in Th1 cells by using U0126 (Figure 5C), a compound that blocks downstream ERK activation.
T9385 1113-1326 Sentence denotes To ensure that only T cell signaling was being affected by U0126, we used an APC-free system in which the T cells were differentiated in the presence of increasing doses of anti-CD3 and a constant amount of IL-12.
T9386 1327-1505 Sentence denotes As in the APC-driven cultures, stronger TCR stimulation together with IL-12 led to higher percentages of cells producing both IL-10 and IFN-γ after 1 week of culture (Figure 5C).
T9387 1506-1611 Sentence denotes Addition of U0126 to the cultures abrogated the production of IL-10 at all doses of anti-CD3 (Figure 5C).
T9388 1612-1975 Sentence denotes Because U0126 inhibits the MEK5-catalyzed activation of ERK5, as well as the MEK1- and MEK2-catalyzed activation of ERK1 and ERK2 (Bain et al., 2007; Mody et al., 2001), we also used the more specific, structurally unrelated MEK1 and MEK2 inhibitor PD184352 at concentrations in which it inhibits MEK1 and MEK2 but not MEK5 (Bain et al., 2007; Mody et al., 2001).
T9389 1976-2101 Sentence denotes PD184352 caused a similar inhibition of IL-10 production by Th1 cells in a dose-dependent fashion (Figure 5D and Figure S5A).
T9390 2102-2310 Sentence denotes Upon addition of inhibitors to other signaling pathways, including a p38 MAPK inhibitor, SB203580, or the GSK3β inhibitor, CT99021 (Bain et al., 2007), no effect on IL-10 production was observed (Figure S5B).
T9391 2311-2503 Sentence denotes Our data thus suggested that IL-10 production by Th1 cells in response to high antigen dose and IL-12 requires ERK1 and ERK2 signaling, but not the activation of the p38 or the GSK3β pathways.
T81 0-63 Sentence denotes IL-10 Production by Th1 Cells Requires ERK1 and ERK2 Activation
T82 64-249 Sentence denotes Our data showed that the maintenance of IL-10 induction in Th1 cells required stimulation with high antigen dose, which to some extent could be compensated for by the addition of IL-12.
T83 250-575 Sentence denotes Signaling through the TCR with high doses of antigen induced stronger ERK1 and ERK2 activation than that induced by low antigen dose, not only in naive CD4+ T cells (data not shown) as previously demonstrated (Jorritsma et al., 2003) but also in CD4+ T cells restimulated with the same high and low antigen doses (Figure 5A).
T84 576-927 Sentence denotes Although the apparent peak and amount of ERK1 and ERK2 activation varied slightly between experiments, a consistent finding was that high antigen dose differentiated Th1 cells always showed enhanced and prolonged ERK1 and ERK2 activation in the presence of IL-12, regardless of whether they were restimulated with high or low antigen dose (Figure 5B).
T85 928-1112 Sentence denotes We then investigated whether ERK1 and ERK2 activation was required for the induction of IL-10 in Th1 cells by using U0126 (Figure 5C), a compound that blocks downstream ERK activation.
T86 1113-1326 Sentence denotes To ensure that only T cell signaling was being affected by U0126, we used an APC-free system in which the T cells were differentiated in the presence of increasing doses of anti-CD3 and a constant amount of IL-12.
T87 1327-1505 Sentence denotes As in the APC-driven cultures, stronger TCR stimulation together with IL-12 led to higher percentages of cells producing both IL-10 and IFN-γ after 1 week of culture (Figure 5C).
T88 1506-1611 Sentence denotes Addition of U0126 to the cultures abrogated the production of IL-10 at all doses of anti-CD3 (Figure 5C).
T89 1612-1975 Sentence denotes Because U0126 inhibits the MEK5-catalyzed activation of ERK5, as well as the MEK1- and MEK2-catalyzed activation of ERK1 and ERK2 (Bain et al., 2007; Mody et al., 2001), we also used the more specific, structurally unrelated MEK1 and MEK2 inhibitor PD184352 at concentrations in which it inhibits MEK1 and MEK2 but not MEK5 (Bain et al., 2007; Mody et al., 2001).
T90 1976-2101 Sentence denotes PD184352 caused a similar inhibition of IL-10 production by Th1 cells in a dose-dependent fashion (Figure 5D and Figure S5A).
T91 2102-2310 Sentence denotes Upon addition of inhibitors to other signaling pathways, including a p38 MAPK inhibitor, SB203580, or the GSK3β inhibitor, CT99021 (Bain et al., 2007), no effect on IL-10 production was observed (Figure S5B).
T92 2311-2503 Sentence denotes Our data thus suggested that IL-10 production by Th1 cells in response to high antigen dose and IL-12 requires ERK1 and ERK2 signaling, but not the activation of the p38 or the GSK3β pathways.

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T10687 0-5 Protein denotes IL-10
T10688 6-16 Gene_expression denotes Production
T10689 30-38 Positive_regulation denotes Requires
T10690 30-38 Positive_regulation denotes Requires
T10691 30-38 Positive_regulation denotes Requires
T10692 30-38 Positive_regulation denotes Requires
T10693 39-43 Protein denotes ERK1
T10694 48-52 Protein denotes ERK2
T10695 53-63 Positive_regulation denotes Activation
T10696 53-63 Positive_regulation denotes Activation
T10697 89-100 Positive_regulation denotes maintenance
T10698 104-109 Protein denotes IL-10
T10699 110-119 Gene_expression denotes induction
T10700 133-141 Positive_regulation denotes required
T10701 231-239 Positive_regulation denotes addition
T10702 243-248 Protein denotes IL-12
T10703 303-310 Positive_regulation denotes induced
T10704 303-310 Positive_regulation denotes induced
T10705 320-324 Protein denotes ERK1
T10706 329-333 Protein denotes ERK2
T10707 334-344 Positive_regulation denotes activation
T10708 334-344 Positive_regulation denotes activation
T10709 355-362 Positive_regulation denotes induced
T10710 355-362 Positive_regulation denotes induced
T10711 402-405 Protein denotes CD4
T10712 496-499 Protein denotes CD4
T10713 617-621 Protein denotes ERK1
T10714 626-630 Protein denotes ERK2
T10715 631-641 Positive_regulation denotes activation
T10716 631-641 Positive_regulation denotes activation
T10717 766-774 Positive_regulation denotes enhanced
T10718 766-774 Positive_regulation denotes enhanced
T10719 779-788 Positive_regulation denotes prolonged
T10720 779-788 Positive_regulation denotes prolonged
T10721 789-793 Protein denotes ERK1
T10722 798-802 Protein denotes ERK2
T10723 803-813 Positive_regulation denotes activation
T10724 803-813 Positive_regulation denotes activation
T10725 833-838 Protein denotes IL-12
T10726 957-961 Protein denotes ERK1
T10727 966-970 Protein denotes ERK2
T10728 971-981 Positive_regulation denotes activation
T10729 971-981 Positive_regulation denotes activation
T10730 986-994 Positive_regulation denotes required true
T10731 986-994 Positive_regulation denotes required true
T10732 1003-1012 Positive_regulation denotes induction
T10733 1016-1021 Protein denotes IL-10
T10734 1291-1294 Protein denotes CD3
T10735 1320-1325 Protein denotes IL-12
T10736 1397-1402 Protein denotes IL-12
T10737 1438-1447 Gene_expression denotes producing
T10738 1438-1447 Gene_expression denotes producing
T10739 1453-1458 Protein denotes IL-10
T10740 1463-1468 Protein denotes IFN-γ
T10741 1540-1549 Negative_regulation denotes abrogated
T10742 1554-1564 Gene_expression denotes production
T10743 1568-1573 Protein denotes IL-10
T10744 1595-1598 Protein denotes CD3
T10745 1626-1634 Negative_regulation denotes inhibits
T10746 1626-1634 Negative_regulation denotes inhibits
T10747 1626-1634 Negative_regulation denotes inhibits
T10748 1626-1634 Negative_regulation denotes inhibits
T10749 1626-1634 Negative_regulation denotes inhibits
T10750 1639-1643 Protein denotes MEK5
T10751 1644-1653 Positive_regulation denotes catalyzed
T10752 1654-1664 Positive_regulation denotes activation
T10753 1668-1672 Protein denotes ERK5
T10754 1689-1693 Protein denotes MEK1
T10755 1699-1703 Protein denotes MEK2
T10756 1704-1713 Positive_regulation denotes catalyzed
T10757 1704-1713 Positive_regulation denotes catalyzed
T10758 1704-1713 Positive_regulation denotes catalyzed
T10759 1704-1713 Positive_regulation denotes catalyzed
T10760 1714-1724 Positive_regulation denotes activation
T10761 1714-1724 Positive_regulation denotes activation
T10762 1728-1732 Protein denotes ERK1
T10763 1737-1741 Protein denotes ERK2
T10764 1837-1841 Protein denotes MEK1
T10765 1846-1850 Protein denotes MEK2
T10766 1851-1860 Negative_regulation denotes inhibitor
T10767 1851-1860 Negative_regulation denotes inhibitor
T10768 1900-1908 Negative_regulation denotes inhibits true
T10769 1900-1908 Negative_regulation denotes inhibits
T10770 1900-1908 Negative_regulation denotes inhibits
T10771 1909-1913 Protein denotes MEK1
T10772 1918-1922 Protein denotes MEK2
T10773 1931-1935 Protein denotes MEK5
T10774 2002-2012 Negative_regulation denotes inhibition
T10775 2016-2021 Protein denotes IL-10
T10776 2022-2032 Gene_expression denotes production
T10777 2171-2179 Protein denotes p38 MAPK
T10778 2180-2189 Negative_regulation denotes inhibitor
T10779 2208-2213 Protein denotes GSK3β
T10780 2214-2223 Negative_regulation denotes inhibitor
T10781 2257-2263 Regulation denotes effect true
T10782 2257-2263 Regulation denotes effect true
T10783 2267-2272 Protein denotes IL-10
T10784 2273-2283 Gene_expression denotes production
T10785 2340-2345 Protein denotes IL-10
T10786 2346-2356 Gene_expression denotes production
T10787 2370-2384 Positive_regulation denotes in response to
T10788 2407-2412 Protein denotes IL-12
T10789 2413-2421 Positive_regulation denotes requires true true
T10790 2413-2421 Positive_regulation denotes requires true true
T10791 2422-2426 Protein denotes ERK1
T10792 2431-2435 Protein denotes ERK2
T10793 2459-2469 Positive_regulation denotes activation
T10794 2459-2469 Positive_regulation denotes activation
T10795 2477-2480 Protein denotes p38
T10796 2488-2493 Protein denotes GSK3β
R8254 T10687 T10688 themeOf IL-10,Production
R8255 T10693 T10695 themeOf ERK1,Activation
R8256 T10694 T10696 themeOf ERK2,Activation
R8257 T10695 T10691 causeOf Activation,Requires
R8258 T10695 T10692 causeOf Activation,Requires
R8259 T10696 T10690 causeOf Activation,Requires
R8260 T10696 T10689 causeOf Activation,Requires
R8261 T10697 T10700 themeOf maintenance,required
R8262 T10698 T10699 themeOf IL-10,induction
R8263 T10699 T10697 themeOf induction,maintenance
R8264 T10702 T10701 themeOf IL-12,addition
R8265 T10705 T10707 themeOf ERK1,activation
R8266 T10706 T10708 themeOf ERK2,activation
R8267 T10707 T10704 themeOf activation,induced
R8268 T10707 T10709 themeOf activation,induced
R8269 T10708 T10703 themeOf activation,induced
R8270 T10708 T10710 themeOf activation,induced
R8271 T10713 T10716 themeOf ERK1,activation
R8272 T10714 T10715 themeOf ERK2,activation
R8273 T10721 T10724 themeOf ERK1,activation
R8274 T10722 T10723 themeOf ERK2,activation
R8275 T10723 T10717 themeOf activation,enhanced
R8276 T10723 T10719 themeOf activation,prolonged
R8277 T10724 T10718 themeOf activation,enhanced
R8278 T10724 T10720 themeOf activation,prolonged
R8279 T10725 T10718 causeOf IL-12,enhanced
R8280 T10725 T10717 causeOf IL-12,enhanced
R8281 T10726 T10729 themeOf ERK1,activation
R8282 T10727 T10728 themeOf ERK2,activation
R8283 T10728 T10731 causeOf activation,required
R8284 T10729 T10730 causeOf activation,required
R8285 T10732 T10730 themeOf induction,required
R8286 T10732 T10731 themeOf induction,required
R8287 T10733 T10732 themeOf IL-10,induction
R8288 T10739 T10738 themeOf IL-10,producing
R8289 T10740 T10737 themeOf IFN-γ,producing
R8290 T10742 T10741 themeOf production,abrogated
R8291 T10743 T10742 themeOf IL-10,production
R8292 T10750 T10751 causeOf MEK5,catalyzed
R8293 T10751 T10745 themeOf catalyzed,inhibits
R8294 T10752 T10751 themeOf activation,catalyzed
R8295 T10753 T10752 themeOf ERK5,activation
R8296 T10754 T10759 causeOf MEK1,catalyzed
R8297 T10754 T10757 causeOf MEK1,catalyzed
R8298 T10755 T10756 causeOf MEK2,catalyzed
R8299 T10755 T10758 causeOf MEK2,catalyzed
R8300 T10756 T10749 themeOf catalyzed,inhibits
R8301 T10757 T10748 themeOf catalyzed,inhibits
R8302 T10758 T10747 themeOf catalyzed,inhibits
R8303 T10759 T10746 themeOf catalyzed,inhibits
R8304 T10760 T10759 themeOf activation,catalyzed
R8305 T10760 T10756 themeOf activation,catalyzed
R8306 T10761 T10757 themeOf activation,catalyzed
R8307 T10761 T10758 themeOf activation,catalyzed
R8308 T10762 T10760 themeOf ERK1,activation
R8309 T10763 T10761 themeOf ERK2,activation
R8310 T10764 T10766 themeOf MEK1,inhibitor
R8311 T10765 T10767 themeOf MEK2,inhibitor
R8312 T10771 T10770 themeOf MEK1,inhibits
R8313 T10772 T10769 themeOf MEK2,inhibits
R8314 T10773 T10768 themeOf MEK5,inhibits
R8315 T10775 T10776 themeOf IL-10,production
R8316 T10776 T10774 themeOf production,inhibition
R8317 T10777 T10778 themeOf p38 MAPK,inhibitor
R8318 T10778 T10781 causeOf inhibitor,effect
R8319 T10779 T10780 themeOf GSK3β,inhibitor
R8320 T10780 T10782 causeOf inhibitor,effect
R8321 T10783 T10784 themeOf IL-10,production
R8322 T10784 T10781 themeOf production,effect
R8323 T10784 T10782 themeOf production,effect
R8324 T10785 T10786 themeOf IL-10,production
R8325 T10786 T10787 themeOf production,in response to
R8326 T10787 T10789 themeOf in response to,requires
R8327 T10787 T10790 themeOf in response to,requires
R8328 T10788 T10787 causeOf IL-12,in response to
R8329 T10793 T10692 themeOf activation,Requires
R8330 T10793 T10689 themeOf activation,Requires
R8331 T10793 T10789 causeOf activation,requires
R8332 T10794 T10690 themeOf activation,Requires
R8333 T10794 T10790 causeOf activation,requires
R8334 T10794 T10691 themeOf activation,Requires
R8335 T10795 T10793 themeOf p38,activation
R8336 T10796 T10794 themeOf GSK3β,activation

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T10797 0-5 Protein denotes IL-10
T10798 39-43 Protein denotes ERK1
T10799 48-52 Protein denotes ERK2
T10800 6-16 Gene_expression denotes Production
T10801 53-63 Positive_regulation denotes Activation
T10802 53-63 Positive_regulation denotes Activation
T10803 104-109 Protein denotes IL-10
T10804 243-248 Protein denotes IL-12
T10805 110-119 Positive_regulation denotes induction
T10806 89-100 Positive_regulation denotes maintenance
T10807 133-141 Positive_regulation denotes required
T10808 272-275 Protein denotes TCR
T10809 320-324 Protein denotes ERK1
T10810 329-333 Protein denotes ERK2
T10811 402-406 Protein denotes CD4+
T10812 496-500 Protein denotes CD4+
T10813 617-621 Protein denotes ERK1
T10814 626-630 Protein denotes ERK2
T10815 789-793 Protein denotes ERK1
T10816 798-802 Protein denotes ERK2
T10817 833-838 Protein denotes IL-12
T10818 631-641 Positive_regulation denotes activation
T10819 631-641 Positive_regulation denotes activation
T10820 803-813 Positive_regulation denotes activation
T10821 803-813 Positive_regulation denotes activation
T10822 779-788 Positive_regulation denotes prolonged
T10823 779-788 Positive_regulation denotes prolonged
T10824 957-961 Protein denotes ERK1
T10825 966-970 Protein denotes ERK2
T10826 1016-1021 Protein denotes IL-10
T10827 1079-1100 Protein denotes blocks downstream ERK
T10828 971-981 Positive_regulation denotes activation
T10829 971-981 Positive_regulation denotes activation
T10830 1003-1012 Positive_regulation denotes induction
T10831 1101-1111 Positive_regulation denotes activation
T10832 1286-1294 Protein denotes anti-CD3
T10833 1320-1325 Protein denotes IL-12
T10834 1367-1370 Protein denotes TCR
T10835 1453-1458 Protein denotes IL-10
T10836 1463-1468 Protein denotes IFN-γ
T10837 1371-1382 Positive_regulation denotes stimulation
T10838 1438-1447 Gene_expression denotes producing
T10839 1438-1447 Gene_expression denotes producing
T10840 1568-1573 Protein denotes IL-10
T10841 1554-1564 Gene_expression denotes production
T10842 1540-1549 Negative_regulation denotes abrogated
T10843 1639-1643 Protein denotes MEK5
T10844 1668-1672 Protein denotes ERK5
T10845 1689-1693 Protein denotes MEK1
T10846 1699-1703 Protein denotes MEK2
T10847 1728-1732 Protein denotes ERK1
T10848 1737-1741 Protein denotes ERK2
T10849 1837-1841 Protein denotes MEK1
T10850 1846-1850 Protein denotes MEK2
T10851 1909-1913 Protein denotes MEK1
T10852 1918-1922 Protein denotes MEK2
T10853 1931-1935 Protein denotes MEK5
T10854 1654-1664 Positive_regulation denotes activation
T10855 1714-1724 Positive_regulation denotes activation
T10856 1714-1724 Positive_regulation denotes activation
T10857 1851-1860 Negative_regulation denotes inhibitor
T10858 1851-1860 Negative_regulation denotes inhibitor
T10859 1900-1908 Negative_regulation denotes inhibits
T10860 1900-1908 Negative_regulation denotes inhibits
T10861 1900-1908 Negative_regulation denotes inhibits
T10862 1626-1634 Negative_regulation denotes inhibits
T10863 1626-1634 Negative_regulation denotes inhibits
T10864 1626-1634 Negative_regulation denotes inhibits
T10865 1644-1653 Positive_regulation denotes catalyzed
T10866 2016-2021 Protein denotes IL-10
T10867 2022-2032 Gene_expression denotes production
T10868 2002-2012 Negative_regulation denotes inhibition
T10869 2171-2179 Protein denotes p38 MAPK
T10870 2208-2213 Protein denotes GSK3β
T10871 2267-2272 Protein denotes IL-10
T10872 2180-2189 Negative_regulation denotes inhibitor
T10873 2214-2223 Negative_regulation denotes inhibitor
T10874 2273-2283 Gene_expression denotes production
T10875 2257-2263 Regulation denotes effect
T10876 2257-2263 Regulation denotes effect
T10877 2407-2412 Protein denotes IL-12
T10878 2422-2426 Protein denotes ERK1
T10879 2431-2435 Protein denotes ERK2
T10880 2477-2480 Protein denotes p38
T10881 2488-2493 Protein denotes GSK3β
T10882 2459-2469 Positive_regulation denotes activation
T10883 2459-2469 Positive_regulation denotes activation
R8337 T10797 T10800 themeOf IL-10,Production
R8338 T10798 T10801 themeOf ERK1,Activation
R8339 T10799 T10802 themeOf ERK2,Activation
R8340 T10803 T10805 themeOf IL-10,induction
R8341 T10805 T10806 themeOf induction,maintenance
R8342 T10806 T10807 themeOf maintenance,required
R8343 T10813 T10818 themeOf ERK1,activation
R8344 T10814 T10819 themeOf ERK2,activation
R8345 T10815 T10820 themeOf ERK1,activation
R8346 T10816 T10821 themeOf ERK2,activation
R8347 T10820 T10822 themeOf activation,prolonged
R8348 T10821 T10823 themeOf activation,prolonged
R8349 T10824 T10828 themeOf ERK1,activation
R8350 T10825 T10829 themeOf ERK2,activation
R8351 T10826 T10830 themeOf IL-10,induction
R8352 T10827 T10831 themeOf blocks downstream ERK,activation
R8353 T10834 T10837 themeOf TCR,stimulation
R8354 T10835 T10838 themeOf IL-10,producing
R8355 T10836 T10839 themeOf IFN-γ,producing
R8356 T10840 T10841 themeOf IL-10,production
R8357 T10841 T10842 themeOf production,abrogated
R8358 T10843 T10865 causeOf MEK5,catalyzed
R8359 T10844 T10854 themeOf ERK5,activation
R8360 T10847 T10855 themeOf ERK1,activation
R8361 T10848 T10856 themeOf ERK2,activation
R8362 T10849 T10857 themeOf MEK1,inhibitor
R8363 T10850 T10858 themeOf MEK2,inhibitor
R8364 T10851 T10859 themeOf MEK1,inhibits
R8365 T10852 T10860 themeOf MEK2,inhibits
R8366 T10853 T10861 themeOf MEK5,inhibits
R8367 T10854 T10862 themeOf activation,inhibits
R8368 T10854 T10865 themeOf activation,catalyzed
R8369 T10855 T10863 themeOf activation,inhibits
R8370 T10856 T10864 themeOf activation,inhibits
R8371 T10866 T10867 themeOf IL-10,production
R8372 T10867 T10868 themeOf production,inhibition
R8373 T10869 T10872 themeOf p38 MAPK,inhibitor
R8374 T10870 T10873 themeOf GSK3β,inhibitor
R8375 T10871 T10874 themeOf IL-10,production
R8376 T10872 T10875 causeOf inhibitor,effect
R8377 T10873 T10876 causeOf inhibitor,effect
R8378 T10874 T10875 themeOf production,effect
R8379 T10874 T10876 themeOf production,effect
R8380 T10880 T10882 themeOf p38,activation
R8381 T10881 T10883 themeOf GSK3β,activation

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T9187 0-5 Protein denotes IL-10
T9188 6-16 Gene_expression denotes Production
T9189 30-38 Positive_regulation denotes Requires
T9190 39-43 Protein denotes ERK1
T9191 48-52 Protein denotes ERK2
T9192 53-63 Positive_regulation denotes Activation
T9193 89-100 Positive_regulation denotes maintenance
T9194 104-109 Protein denotes IL-10
T9195 110-119 Positive_regulation denotes induction
T9196 133-141 Positive_regulation denotes required
T9197 243-248 Protein denotes IL-12
T9198 303-310 Positive_regulation denotes induced
T9199 311-319 Positive_regulation denotes stronger
T9200 320-324 Protein denotes ERK1
T9201 329-333 Protein denotes ERK2
T9202 334-344 Positive_regulation denotes activation
T9203 355-362 Positive_regulation denotes induced
T9204 402-405 Protein denotes CD4
T9205 496-499 Protein denotes CD4
T9206 617-621 Protein denotes ERK1
T9207 626-630 Protein denotes ERK2
T9208 631-641 Positive_regulation denotes activation
T9209 766-774 Positive_regulation denotes enhanced
T9210 779-788 Positive_regulation denotes prolonged
T9211 789-793 Protein denotes ERK1
T9212 798-802 Protein denotes ERK2
T9213 803-813 Positive_regulation denotes activation
T9214 833-838 Protein denotes IL-12
T9215 957-961 Protein denotes ERK1
T9216 966-970 Protein denotes ERK2 true
T9217 971-981 Positive_regulation denotes activation
T9218 986-994 Positive_regulation denotes required true
T9219 1003-1012 Positive_regulation denotes induction
T9220 1016-1021 Protein denotes IL-10
T9221 1291-1294 Protein denotes CD3
T9222 1320-1325 Protein denotes IL-12
T9223 1397-1402 Protein denotes IL-12
T9224 1438-1447 Gene_expression denotes producing
T9225 1453-1458 Protein denotes IL-10
T9226 1463-1468 Protein denotes IFN-γ
T9227 1540-1549 Negative_regulation denotes abrogated
T9228 1554-1564 Gene_expression denotes production
T9229 1568-1573 Protein denotes IL-10
T9230 1595-1598 Protein denotes CD3
T9231 1626-1634 Negative_regulation denotes inhibits
T9232 1639-1643 Protein denotes MEK5
T9233 1644-1653 Positive_regulation denotes catalyzed
T9234 1654-1664 Positive_regulation denotes activation
T9235 1668-1672 Protein denotes ERK5
T9236 1689-1693 Protein denotes MEK1
T9237 1699-1703 Protein denotes MEK2
T9238 1704-1713 Positive_regulation denotes catalyzed
T9239 1714-1724 Positive_regulation denotes activation
T9240 1728-1732 Protein denotes ERK1 true
T9241 1737-1741 Protein denotes ERK2
T9242 1837-1841 Protein denotes MEK1
T9243 1846-1850 Protein denotes MEK2
T9244 1851-1860 Negative_regulation denotes inhibitor
T9245 1900-1908 Negative_regulation denotes inhibits true
T9246 1909-1913 Protein denotes MEK1
T9247 1918-1922 Protein denotes MEK2 true
T9248 1931-1935 Protein denotes MEK5
T9249 2002-2012 Negative_regulation denotes inhibition
T9250 2016-2021 Protein denotes IL-10 true true
T9251 2022-2032 Gene_expression denotes production true true
T9252 2171-2179 Protein denotes p38 MAPK
T9253 2180-2189 Negative_regulation denotes inhibitor
T9254 2208-2213 Protein denotes GSK3β
T9255 2214-2223 Negative_regulation denotes inhibitor
T9256 2257-2263 Regulation denotes effect
T9257 2267-2272 Protein denotes IL-10
T9258 2273-2283 Gene_expression denotes production
T9259 2340-2345 Protein denotes IL-10
T9260 2346-2356 Gene_expression denotes production
T9261 2370-2384 Positive_regulation denotes in response to
T9262 2385-2389 Positive_regulation denotes high
T9263 2407-2412 Protein denotes IL-12
T9264 2413-2421 Positive_regulation denotes requires
T9265 2422-2426 Protein denotes ERK1
T9266 2431-2435 Protein denotes ERK2
T9267 2459-2469 Positive_regulation denotes activation
T9268 2477-2480 Protein denotes p38
T9269 2488-2493 Protein denotes GSK3β
R7021 T9187 T9188 themeOf IL-10,Production
R7022 T9188 T9189 themeOf Production,Requires
R7023 T9190 T9192 themeOf ERK1,Activation
R7024 T9191 T9192 themeOf ERK2,Activation
R7025 T9192 T9189 causeOf Activation,Requires
R7026 T9193 T9196 themeOf maintenance,required
R7027 T9194 T9195 themeOf IL-10,induction
R7028 T9195 T9196 themeOf induction,required
R7029 T9195 T9193 themeOf induction,maintenance
R7030 T9198 T9203 themeOf induced,induced
R7031 T9199 T9198 themeOf stronger,induced
R7032 T9200 T9202 themeOf ERK1,activation
R7033 T9201 T9202 themeOf ERK2,activation
R7034 T9202 T9199 themeOf activation,stronger
R7035 T9202 T9203 themeOf activation,induced
R7036 T9202 T9198 themeOf activation,induced
R7037 T9206 T9208 themeOf ERK1,activation
R7038 T9207 T9208 themeOf ERK2,activation
R7039 T9208 T9209 themeOf activation,enhanced
R7040 T9211 T9213 themeOf ERK1,activation
R7041 T9212 T9213 themeOf ERK2,activation
R7042 T9213 T9210 themeOf activation,prolonged
R7043 T9215 T9217 themeOf ERK1,activation
R7044 T9216 T9217 themeOf ERK2,activation
R7045 T9217 T9218 causeOf activation,required
R7046 T9219 T9218 themeOf induction,required
R7047 T9220 T9219 themeOf IL-10,induction
R7048 T9225 T9224 themeOf IL-10,producing
R7049 T9226 T9224 themeOf IFN-γ,producing
R7050 T9228 T9227 themeOf production,abrogated
R7051 T9229 T9228 themeOf IL-10,production
R7052 T9232 T9233 causeOf MEK5,catalyzed
R7053 T9233 T9231 themeOf catalyzed,inhibits
R7054 T9234 T9233 themeOf activation,catalyzed
R7055 T9235 T9234 themeOf ERK5,activation
R7056 T9236 T9238 causeOf MEK1,catalyzed
R7057 T9237 T9238 causeOf MEK2,catalyzed
R7058 T9239 T9238 themeOf activation,catalyzed
R7059 T9240 T9239 themeOf ERK1,activation
R7060 T9241 T9239 themeOf ERK2,activation
R7061 T9242 T9244 themeOf MEK1,inhibitor
R7062 T9243 T9244 themeOf MEK2,inhibitor
R7063 T9246 T9245 themeOf MEK1,inhibits
R7064 T9247 T9245 themeOf MEK2,inhibits
R7065 T9248 T9245 themeOf MEK5,inhibits
R7066 T9250 T9251 themeOf IL-10,production
R7067 T9251 T9249 themeOf production,inhibition
R7068 T9252 T9253 themeOf p38 MAPK,inhibitor
R7069 T9253 T9256 causeOf inhibitor,effect
R7070 T9254 T9255 themeOf GSK3β,inhibitor
R7071 T9255 T9256 causeOf inhibitor,effect
R7072 T9257 T9258 themeOf IL-10,production
R7073 T9258 T9256 themeOf production,effect
R7074 T9259 T9260 themeOf IL-10,production
R7075 T9260 T9264 themeOf production,requires
R7076 T9260 T9261 themeOf production,in response to
R7077 T9261 T9264 themeOf in response to,requires
R7078 T9262 T9261 causeOf high,in response to
R7079 T9263 T9261 causeOf IL-12,in response to
R7080 T9267 T9264 causeOf activation,requires
R7081 T9268 T9267 themeOf p38,activation
R7082 T9269 T9267 themeOf GSK3β,activation