PMC:2700745 / 18415-19382
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2700745","sourcedb":"PMC","sourceid":"2700745","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2700745","text":"The mouse remains the primary model for evaluating the antiviral therapy of influenza pneumonia, due to the inexpensiveness of the animals and their caging and the general fidelity of the illness in mice to the human disease (Sidwell and Smee, 2004). In addition, many reagents are available to study the effects of virus replication and treatment on the mouse immune system. The laboratory mouse can be experimentally infected with both seasonal influenza A viruses and influenza B viruses, but this usually requires some adaptation by multiple lung passage. The adapted virus can then infect murine lung cells, probably as a result of amino acid changes in the surface hemagglutinins that enable it to bind to cell-surface alpha 2,3-linked sialic acid molecules (Ibricevic et al., 2006). A recent advance in influenza A modeling has been the finding that the reconstructed 1918 pandemic influenza virus is lethal for mice (Jeffery et al., 2001, Taubenberger, 2006).","tracks":[{"project":"2_test","denotations":[{"id":"19176218-16840327-100518323","span":{"begin":783,"end":787},"obj":"16840327"},{"id":"19176218-16840327-100518323","span":{"begin":783,"end":787},"obj":"16840327"},{"id":"19176218-17526158-100518324","span":{"begin":961,"end":965},"obj":"17526158"},{"id":"19176218-17526158-100518324","span":{"begin":961,"end":965},"obj":"17526158"},{"id":"19176218-16840327-3579189","span":{"begin":783,"end":787},"obj":"16840327"},{"id":"19176218-16840327-3579189","span":{"begin":783,"end":787},"obj":"16840327"},{"id":"19176218-17526158-3579190","span":{"begin":961,"end":965},"obj":"17526158"},{"id":"19176218-17526158-3579190","span":{"begin":961,"end":965},"obj":"17526158"}],"attributes":[{"subj":"19176218-16840327-100518323","pred":"source","obj":"2_test"},{"subj":"19176218-16840327-100518323","pred":"source","obj":"2_test"},{"subj":"19176218-17526158-100518324","pred":"source","obj":"2_test"},{"subj":"19176218-17526158-100518324","pred":"source","obj":"2_test"},{"subj":"19176218-16840327-3579189","pred":"source","obj":"2_test"},{"subj":"19176218-16840327-3579189","pred":"source","obj":"2_test"},{"subj":"19176218-17526158-3579190","pred":"source","obj":"2_test"},{"subj":"19176218-17526158-3579190","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93eb","default":true}]}]}}