PMC:2700745 / 10582-11203 JSONTXT

{"project":"2_test","denotations":[{"id":"19176218-15474733-3579170","span":{"begin":504,"end":508},"obj":"15474733"},{"id":"19176218-15474733-3579170","span":{"begin":504,"end":508},"obj":"15474733"},{"id":"T43558","span":{"begin":504,"end":508},"obj":"15474733"},{"id":"T33621","span":{"begin":504,"end":508},"obj":"15474733"}],"text":"The utility of a ferret model in which a benign infection was induced is illustrated by the results from the following vaccine study. Ferrets immunized with virosome-based intranasal influenza vaccine consisting of hemagglutinins from influenza A/Beijing/262/95like (H1N1), A/Sydney/5/97 (H3N2), and influenza B/Harbin/7/94 and then challenged with the A/Sydney/5/97 (H3N2) strain had less viral shedding in nasal secretions and the vaccine elicited a vaccine-specific antibody response (Lambkin et al., 2004). In addition, the vaccine regimen protected against fever, weight loss, and infiltration of inflammatory cells."}