PMC:2678986 / 9482-10247 JSONTXT

{"project":"2_test","denotations":[{"id":"19176219-16011870-99578272","span":{"begin":200,"end":204},"obj":"16011870"},{"id":"19176219-16011870-99578272","span":{"begin":200,"end":204},"obj":"16011870"},{"id":"19176219-16011870-3576926","span":{"begin":200,"end":204},"obj":"16011870"},{"id":"19176219-16011870-3576926","span":{"begin":200,"end":204},"obj":"16011870"}],"text":"ABC transporters are the most extensively studied group, which are responsible for the cellular extrusion of a variety of molecules by using energy produced from ATP hydrolysis (Loscher and Potschka, 2005). P-Glycoprotein (P-gp) (also known as MDR-1 or ABCB1) is the most characterised ABC transporter. Other members of the superfamily include multi-drug resistance-associated proteins (MRPs) (also referred to as ABCC transporters) and breast cancer resistance protein (BCRP) (also known as ABCG2). Recent studies have demonstrated that the expression of these transporters at the BBB and on other cells such as lymphocytes, CD4+ T cells and microglia, play a crucial role in permitting the entry of anti-HIV drugs into cellular and anatomical reservoirs of HIV-1."}