PMC:2678986 / 6459-7234
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2678986","sourcedb":"PMC","sourceid":"2678986","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2678986","text":"2 Anti-HIV drugs\nAccording to US and British guidelines, the goal of HIV therapy must always be to achieve a viral load of \u003c50 copies/mL within 4–6 months of starting treatment (Gazzard, 2008; Department of Health and Human Services, 2008). Traditionally, the main classes of anti-HIV drugs used include NRTIs, NNRTIs, NtRTIs and PIs (Table 1). However, other classes are also available including integrase inhibitors and entry inhibitors such as fusion and CCR5 inhibitors (Qian et al., 2009). HAART comprises the combined use of three or more anti-HIV drugs. The current recommended first line of treatment is a NNRTI, efavirenz, with the nucleoside backbone Truvada® (emtricitabine and tenofovir disoproxil fumarate) and Kivexa® (abacavir and lamivudine) (Gazzard, 2008).","divisions":[{"label":"label","span":{"begin":0,"end":1}},{"label":"title","span":{"begin":3,"end":17}}],"tracks":[{"project":"2_test","denotations":[{"id":"19176219-18826546-99578266","span":{"begin":188,"end":192},"obj":"18826546"},{"id":"19176219-18826546-99578266","span":{"begin":188,"end":192},"obj":"18826546"},{"id":"19176219-18826546-99578267","span":{"begin":769,"end":773},"obj":"18826546"},{"id":"19176219-18826546-99578267","span":{"begin":769,"end":773},"obj":"18826546"},{"id":"19176219-18826546-3576919","span":{"begin":188,"end":192},"obj":"18826546"},{"id":"19176219-18826546-3576919","span":{"begin":188,"end":192},"obj":"18826546"},{"id":"19176219-18720513-3576920","span":{"begin":489,"end":493},"obj":"18720513"},{"id":"19176219-18720513-3576920","span":{"begin":489,"end":493},"obj":"18720513"},{"id":"19176219-18826546-3576921","span":{"begin":769,"end":773},"obj":"18826546"},{"id":"19176219-18826546-3576921","span":{"begin":769,"end":773},"obj":"18826546"}],"attributes":[{"subj":"19176219-18826546-99578266","pred":"source","obj":"2_test"},{"subj":"19176219-18826546-99578266","pred":"source","obj":"2_test"},{"subj":"19176219-18826546-99578267","pred":"source","obj":"2_test"},{"subj":"19176219-18826546-99578267","pred":"source","obj":"2_test"},{"subj":"19176219-18826546-3576919","pred":"source","obj":"2_test"},{"subj":"19176219-18826546-3576919","pred":"source","obj":"2_test"},{"subj":"19176219-18720513-3576920","pred":"source","obj":"2_test"},{"subj":"19176219-18720513-3576920","pred":"source","obj":"2_test"},{"subj":"19176219-18826546-3576921","pred":"source","obj":"2_test"},{"subj":"19176219-18826546-3576921","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#9f93ec","default":true}]}]}}