PMC:2678986 / 32838-33642 JSONTXT

{"project":"2_test","denotations":[{"id":"19176219-15962513-99578381","span":{"begin":201,"end":205},"obj":"15962513"},{"id":"19176219-15962513-99578381","span":{"begin":201,"end":205},"obj":"15962513"},{"id":"19176219-18508884-99578382","span":{"begin":220,"end":224},"obj":"18508884"},{"id":"19176219-18508884-99578382","span":{"begin":220,"end":224},"obj":"18508884"},{"id":"19176219-15962513-99578383","span":{"begin":798,"end":802},"obj":"15962513"},{"id":"19176219-15962513-99578383","span":{"begin":798,"end":802},"obj":"15962513"},{"id":"19176219-15962513-3577011","span":{"begin":220,"end":224},"obj":"15962513"},{"id":"19176219-15962513-3577011","span":{"begin":220,"end":224},"obj":"15962513"},{"id":"19176219-18508884-3577011","span":{"begin":220,"end":224},"obj":"18508884"},{"id":"19176219-18508884-3577011","span":{"begin":220,"end":224},"obj":"18508884"},{"id":"19176219-15962513-3577012","span":{"begin":798,"end":802},"obj":"15962513"},{"id":"19176219-15962513-3577012","span":{"begin":798,"end":802},"obj":"15962513"}],"text":"BBB disruption during HIV infection is thought to provide a primary portal for infected cells to enter the brain and to contribute significantly to neuropathology such as HIVE and HAD (Toborek et al., 2005; Wang et al., 2008). Several processes have been attributed to the disruption of the BBB in HIV infection, in addition to those discussed earlier. Morphological changes such as an increase in the diameter of cortical vessels as well as alterations such as the thinning of basal lamina and loss of glycoproteins present in endothelial cells are all features of the disrupted BBB observed in HIV-infected patients. Furthermore, apoptosis of endothelial cells and tight junction disruption are thought to be other mechanisms by which the integrity of the BBB is impaired in HIV (Toborek et al., 2005)."}