PMC:2678986 / 27672-28758
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2678986","sourcedb":"PMC","sourceid":"2678986","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2678986","text":"A recent study suggested that the PIs, nelfinavir, ritonavir, saquinavir and indinavir are possibly inhibitors of OCT1 and OCT2 (Jung et al., 2008). This supported evidence provided by Zhang et al. (2000) that some HIV PIs may be potent inhibitors of cationic drug uptake, but poor substrates for human OCT1 (Zhang et al., 2000). Furthermore, the NRTIs, lamivudine and zalcitabine are substrates of OCT1 and OCT2 (Jung et al., 2008). Moreover, when assessing the expression of OCTs in lymph nodes of HIV-infected patients in comparison to healthy controls, Jung and colleagues found that OCT1 and OCT2 were upregulated in the lymph nodes of HIV-infected patients, indicating that the accumulation of OCT substrates would be much higher in the lymph nodes of these patients. This could be due to the activation of the immune system and effects of cytokines induced by HIV infection (Jung et al., 2008). This study implies that a sound knowledge of OCTs is crucial in understanding both drug interactions that may occur with HAART and also the role they play in regulating drug transport.","tracks":[{"project":"2_test","denotations":[{"id":"19176219-10681378-99578361","span":{"begin":199,"end":203},"obj":"10681378"},{"id":"19176219-10681378-99578361","span":{"begin":199,"end":203},"obj":"10681378"},{"id":"19176219-10681378-99578362","span":{"begin":323,"end":327},"obj":"10681378"},{"id":"19176219-10681378-99578362","span":{"begin":323,"end":327},"obj":"10681378"},{"id":"19176219-18490433-3576993","span":{"begin":142,"end":146},"obj":"18490433"},{"id":"19176219-18490433-3576993","span":{"begin":142,"end":146},"obj":"18490433"},{"id":"19176219-10681378-3576994","span":{"begin":199,"end":203},"obj":"10681378"},{"id":"19176219-10681378-3576994","span":{"begin":199,"end":203},"obj":"10681378"},{"id":"19176219-10681378-3576995","span":{"begin":323,"end":327},"obj":"10681378"},{"id":"19176219-10681378-3576995","span":{"begin":323,"end":327},"obj":"10681378"},{"id":"19176219-18490433-3576996","span":{"begin":427,"end":431},"obj":"18490433"},{"id":"19176219-18490433-3576996","span":{"begin":427,"end":431},"obj":"18490433"},{"id":"19176219-18490433-3576997","span":{"begin":895,"end":899},"obj":"18490433"},{"id":"19176219-18490433-3576997","span":{"begin":895,"end":899},"obj":"18490433"}],"attributes":[{"subj":"19176219-10681378-99578361","pred":"source","obj":"2_test"},{"subj":"19176219-10681378-99578361","pred":"source","obj":"2_test"},{"subj":"19176219-10681378-99578362","pred":"source","obj":"2_test"},{"subj":"19176219-10681378-99578362","pred":"source","obj":"2_test"},{"subj":"19176219-18490433-3576993","pred":"source","obj":"2_test"},{"subj":"19176219-18490433-3576993","pred":"source","obj":"2_test"},{"subj":"19176219-10681378-3576994","pred":"source","obj":"2_test"},{"subj":"19176219-10681378-3576994","pred":"source","obj":"2_test"},{"subj":"19176219-10681378-3576995","pred":"source","obj":"2_test"},{"subj":"19176219-10681378-3576995","pred":"source","obj":"2_test"},{"subj":"19176219-18490433-3576996","pred":"source","obj":"2_test"},{"subj":"19176219-18490433-3576996","pred":"source","obj":"2_test"},{"subj":"19176219-18490433-3576997","pred":"source","obj":"2_test"},{"subj":"19176219-18490433-3576997","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#bc93ec","default":true}]}]}}