PMC:2678986 / 2331-3250
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2678986","sourcedb":"PMC","sourceid":"2678986","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2678986","text":"HIV infection in the CNS is associated with the development of asymptomatic neurocognitive impairment, HIV-associated mild neurocognitive disorder (MND), and eventually HIV-associated dementia (HAD) or AIDS dementia complex that manifests as a clinical syndrome of cognitive, motor and behavioural dysfunction (Antinori et al., 2007). These neurological complications arise most likely due to the early penetration of HIV-1 into the CNS via infected immune cells such as CD4+ T lymphocytes, dendritic cells, monocytes and macrophages, which are all cellular reservoirs of HIV-1 (Valcour and Paul, 2006; McArthur, 2004; Blankson et al., 2002). A key feature of HIV populations in the CSF is that initially they may be identical to that in the plasma, but as the infection progresses the viral populations diverge, with the greatest divergence being observed in patients with HAD (Wong et al., 1997; Strain et al., 2005).","tracks":[{"project":"2_test","denotations":[{"id":"19176219-17914061-99578253","span":{"begin":328,"end":332},"obj":"17914061"},{"id":"19176219-17914061-99578253","span":{"begin":328,"end":332},"obj":"17914061"},{"id":"19176219-16619159-99578254","span":{"begin":597,"end":601},"obj":"16619159"},{"id":"19176219-16619159-99578254","span":{"begin":597,"end":601},"obj":"16619159"},{"id":"19176219-15579274-99578255","span":{"begin":613,"end":617},"obj":"15579274"},{"id":"19176219-15579274-99578255","span":{"begin":613,"end":617},"obj":"15579274"},{"id":"19176219-11818490-99578256","span":{"begin":636,"end":640},"obj":"11818490"},{"id":"19176219-11818490-99578256","span":{"begin":636,"end":640},"obj":"11818490"},{"id":"19176219-9032338-99578257","span":{"begin":892,"end":896},"obj":"9032338"},{"id":"19176219-9032338-99578257","span":{"begin":892,"end":896},"obj":"9032338"},{"id":"19176219-15650202-99578258","span":{"begin":913,"end":917},"obj":"15650202"},{"id":"19176219-15650202-99578258","span":{"begin":913,"end":917},"obj":"15650202"},{"id":"19176219-17914061-3576911","span":{"begin":328,"end":332},"obj":"17914061"},{"id":"19176219-17914061-3576911","span":{"begin":328,"end":332},"obj":"17914061"},{"id":"19176219-16619159-3576912","span":{"begin":636,"end":640},"obj":"16619159"},{"id":"19176219-16619159-3576912","span":{"begin":636,"end":640},"obj":"16619159"},{"id":"19176219-15579274-3576912","span":{"begin":636,"end":640},"obj":"15579274"},{"id":"19176219-15579274-3576912","span":{"begin":636,"end":640},"obj":"15579274"},{"id":"19176219-11818490-3576912","span":{"begin":636,"end":640},"obj":"11818490"},{"id":"19176219-11818490-3576912","span":{"begin":636,"end":640},"obj":"11818490"},{"id":"19176219-9032338-3576913","span":{"begin":913,"end":917},"obj":"9032338"},{"id":"19176219-9032338-3576913","span":{"begin":913,"end":917},"obj":"9032338"},{"id":"19176219-15650202-3576913","span":{"begin":913,"end":917},"obj":"15650202"},{"id":"19176219-15650202-3576913","span":{"begin":913,"end":917},"obj":"15650202"}],"attributes":[{"subj":"19176219-17914061-99578253","pred":"source","obj":"2_test"},{"subj":"19176219-17914061-99578253","pred":"source","obj":"2_test"},{"subj":"19176219-16619159-99578254","pred":"source","obj":"2_test"},{"subj":"19176219-16619159-99578254","pred":"source","obj":"2_test"},{"subj":"19176219-15579274-99578255","pred":"source","obj":"2_test"},{"subj":"19176219-15579274-99578255","pred":"source","obj":"2_test"},{"subj":"19176219-11818490-99578256","pred":"source","obj":"2_test"},{"subj":"19176219-11818490-99578256","pred":"source","obj":"2_test"},{"subj":"19176219-9032338-99578257","pred":"source","obj":"2_test"},{"subj":"19176219-9032338-99578257","pred":"source","obj":"2_test"},{"subj":"19176219-15650202-99578258","pred":"source","obj":"2_test"},{"subj":"19176219-15650202-99578258","pred":"source","obj":"2_test"},{"subj":"19176219-17914061-3576911","pred":"source","obj":"2_test"},{"subj":"19176219-17914061-3576911","pred":"source","obj":"2_test"},{"subj":"19176219-16619159-3576912","pred":"source","obj":"2_test"},{"subj":"19176219-16619159-3576912","pred":"source","obj":"2_test"},{"subj":"19176219-15579274-3576912","pred":"source","obj":"2_test"},{"subj":"19176219-15579274-3576912","pred":"source","obj":"2_test"},{"subj":"19176219-11818490-3576912","pred":"source","obj":"2_test"},{"subj":"19176219-11818490-3576912","pred":"source","obj":"2_test"},{"subj":"19176219-9032338-3576913","pred":"source","obj":"2_test"},{"subj":"19176219-9032338-3576913","pred":"source","obj":"2_test"},{"subj":"19176219-15650202-3576913","pred":"source","obj":"2_test"},{"subj":"19176219-15650202-3576913","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93eca5","default":true}]}]}}