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PMC:2674207 / 455-2163 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T166 0-10 NN denotes Background
T167 11-17 NN denotes GATA-3
T168 18-23 VB denotes plays
T169 24-25 DT denotes a
T170 26-34 JJ denotes critical
T171 35-39 NN denotes role
T172 40-42 IN denotes in
T173 43-53 VB denotes regulating
T174 54-57 DT denotes the
T175 58-68 NN denotes expression
T176 69-71 IN denotes of
T177 72-75 DT denotes the
T178 76-85 NN denotes cytokines
T179 86-97 NN denotes interleukin
T180 98-99 -LRB- denotes (
T181 99-101 NN denotes IL
T182 101-102 -RRB- denotes )
T183 102-104 CD denotes -4
T184 104-105 -COMMA- denotes ,
T185 106-110 NN denotes IL-5
T186 110-111 -COMMA- denotes ,
T187 112-115 CC denotes and
T188 116-121 NN denotes IL-13
T189 122-126 IN denotes from
T190 127-128 NN denotes T
T191 129-137 NN denotes helper-2
T192 138-139 -LRB- denotes (
T193 139-142 NN denotes Th2
T194 142-143 -RRB- denotes )
T195 144-149 NN denotes cells
T196 150-153 CC denotes and
T197 154-163 RB denotes therefore
T198 164-166 VB denotes is
T199 167-168 DT denotes a
T200 169-172 JJ denotes key
T201 173-181 NN denotes mediator
T202 182-184 IN denotes of
T203 185-193 JJ denotes allergic
T204 194-202 NN denotes diseases
T205 204-219 NN denotes Corticosteroids
T206 220-223 VB denotes are
T207 224-230 RB denotes highly
T208 231-240 JJ denotes effective
T209 241-243 IN denotes in
T210 244-255 VB denotes suppressing
T211 256-264 JJ denotes allergic
T212 265-277 NN denotes inflammation
T213 277-278 -COMMA- denotes ,
T214 279-282 CC denotes but
T215 283-288 PRP-DOLLAR- denotes their
T216 289-296 NN denotes effects
T217 297-299 IN denotes on
T218 300-306 NN denotes GATA-3
T219 307-310 VB denotes are
T220 311-318 JJ denotes unknown
T221 320-322 PRP denotes We
T222 323-335 VB denotes investigated
T223 336-339 DT denotes the
T224 340-346 NN denotes effect
T225 347-349 IN denotes of
T226 350-353 DT denotes the
T227 354-368 NN denotes corticosteroid
T228 369-380 NN denotes fluticasone
T229 381-391 NN denotes propionate
T230 392-394 IN denotes on
T231 395-401 NN denotes GATA-3
T232 402-412 NN denotes regulation
T233 413-415 IN denotes in
T234 416-421 JJ denotes human
T235 422-435 NN denotes T-lymphocytes
T236 436-438 FW denotes in
T237 439-444 FW denotes vitro
T238 445-448 CC denotes and
T239 449-451 FW denotes in
T240 452-456 FW denotes vivo
T241 459-466 NN denotes Methods
T242 467-470 CC denotes and
T243 471-479 NN denotes Findings
T244 480-482 IN denotes In
T245 483-484 DT denotes a
T246 485-486 NN denotes T
T247 487-497 NN denotes lymphocyte
T248 498-502 NN denotes cell
T249 503-507 NN denotes line
T250 508-509 -LRB- denotes (
T251 509-515 NN denotes HuT-78
T252 515-516 -RRB- denotes )
T253 517-520 CC denotes and
T254 521-531 JJ denotes peripheral
T255 532-537 NN denotes blood
T256 538-549 JJ denotes mononuclear
T257 550-555 NN denotes cells
T258 556-566 VB denotes stimulated
T259 567-569 IN denotes by
T260 570-578 JJ denotes anti-CD3
T261 579-582 CC denotes and
T262 583-592 JJ denotes anti-CD28
T263 593-595 FW denotes in
T264 596-601 FW denotes vitro
T265 602-604 PRP denotes we
T266 605-617 VB denotes demonstrated
T267 618-622 IN denotes that
T268 623-634 NN denotes fluticasone
T269 635-643 VB denotes inhibits
T270 644-651 JJ denotes nuclear
T271 652-665 NN denotes translocation
T272 666-668 IN denotes of
T273 669-675 NN denotes GATA-3
T274 676-679 CC denotes and
T275 680-690 NN denotes expression
T276 691-693 IN denotes of
T277 694-697 NN denotes Th2
T278 698-707 NN denotes cytokines
T279 708-711 IN denotes via
T280 712-713 DT denotes a
T281 714-723 NN denotes mechanism
T282 724-735 JJ denotes independent
T283 736-738 IN denotes of
T284 739-746 JJ denotes nuclear
T285 747-756 NN denotes factor-κB
T286 757-760 CC denotes and
T287 761-763 VB denotes is
T288 764-767 JJ denotes due
T289 767-768 -COMMA- denotes ,
T290 769-771 IN denotes in
T291 772-776 NN denotes part
T292 776-777 -COMMA- denotes ,
T293 778-780 TO denotes to
T294 781-792 NN denotes competition
T295 793-800 IN denotes between
T296 801-807 NN denotes GATA-3
T297 808-811 CC denotes and
T298 812-815 DT denotes the
T299 816-832 JJ denotes ligand-activated
T300 833-847 NN denotes glucocorticoid
T301 848-856 NN denotes receptor
T302 857-860 IN denotes for
T303 861-868 JJ denotes nuclear
T304 869-878 NN denotes transport
T305 879-886 IN denotes through
T306 887-890 DT denotes the
T307 891-898 JJ denotes nuclear
T308 899-907 NN denotes importer
T309 908-918 NN denotes importin-α
T310 920-922 IN denotes In
T311 923-931 NN denotes addition
T312 931-932 -COMMA- denotes ,
T313 933-944 NN denotes fluticasone
T314 945-952 VB denotes induces
T315 953-956 DT denotes the
T316 957-967 NN denotes expression
T317 968-970 IN denotes of
T318 971-988 JJ denotes mitogen-activated
T319 989-996 NN denotes protein
T320 997-1003 NN denotes kinase
T321 1004-1005 -LRB- denotes (
T322 1005-1009 NN denotes MAPK
T323 1009-1010 -RRB- denotes )
T324 1011-1024 NN denotes phosphatase-1
T325 1025-1026 -LRB- denotes (
T326 1026-1031 NN denotes MKP-1
T327 1031-1032 -RRB- denotes )
T328 1032-1033 -COMMA- denotes ,
T329 1034-1037 DT denotes the
T330 1038-1048 JJ denotes endogenous
T331 1049-1058 NN denotes inhibitor
T332 1059-1061 IN denotes of
T333 1062-1065 NN denotes p38
T334 1066-1070 NN denotes MAPK
T335 1070-1071 -COMMA- denotes ,
T336 1072-1077 WDT denotes which
T337 1078-1080 VB denotes is
T338 1081-1090 JJ denotes necessary
T339 1091-1094 IN denotes for
T340 1095-1101 NN denotes GATA-3
T341 1102-1109 JJ denotes nuclear
T342 1110-1123 NN denotes translocation
T343 1125-1130 DT denotes These
T344 1131-1141 JJ denotes inhibitory
T345 1142-1149 NN denotes effects
T346 1150-1152 IN denotes of
T347 1153-1164 NN denotes fluticasone
T348 1165-1168 VB denotes are
T349 1169-1174 JJ denotes rapid
T350 1174-1175 -COMMA- denotes ,
T351 1176-1182 JJ denotes potent
T352 1182-1183 -COMMA- denotes ,
T353 1184-1187 CC denotes and
T354 1188-1197 VB denotes prolonged
T355 1199-1201 PRP denotes We
T356 1202-1206 RB denotes also
T357 1207-1219 VB denotes demonstrated
T358 1220-1224 IN denotes that
T359 1225-1232 VB denotes inhaled
T360 1233-1244 NN denotes fluticasone
T361 1245-1253 VB denotes inhibits
T362 1254-1260 NN denotes GATA-3
T363 1261-1268 JJ denotes nuclear
T364 1269-1282 NN denotes translocation
T365 1283-1285 IN denotes in
T366 1286-1296 JJ denotes peripheral
T367 1297-1302 NN denotes blood
T368 1303-1314 NN denotes lymphocytes
T369 1315-1317 IN denotes of
T370 1318-1326 NN denotes patients
T371 1327-1331 IN denotes with
T372 1332-1338 NN denotes asthma
T373 1339-1341 FW denotes in
T374 1342-1346 FW denotes vivo
T375 1349-1360 NN denotes Conclusions
T376 1361-1376 NN denotes Corticosteroids
T377 1377-1381 VB denotes have
T378 1382-1383 DT denotes a
T379 1384-1390 JJ denotes potent
T380 1391-1401 JJ denotes inhibitory
T381 1402-1408 NN denotes effect
T382 1409-1411 IN denotes on
T383 1412-1418 NN denotes GATA-3
T384 1419-1422 IN denotes via
T385 1423-1426 CD denotes two
T386 1427-1438 VB denotes interacting
T387 1439-1449 NN denotes mechanisms
T388 1450-1454 WDT denotes that
T389 1455-1463 RB denotes potently
T390 1464-1472 VB denotes suppress
T391 1473-1476 NN denotes Th2
T392 1477-1485 NN denotes cytokine
T393 1486-1496 NN denotes expression
T394 1498-1502 DT denotes This
T395 1503-1508 JJ denotes novel
T396 1509-1518 NN denotes mechanism
T397 1519-1521 IN denotes of
T398 1522-1528 NN denotes action
T399 1529-1531 IN denotes of
T400 1532-1547 NN denotes corticosteroids
T401 1548-1551 MD denotes may
T402 1552-1559 VB denotes account
T403 1560-1563 IN denotes for
T404 1564-1567 DT denotes the
T405 1568-1576 JJ denotes striking
T406 1577-1585 JJ denotes clinical
T407 1586-1594 NN denotes efficacy
T408 1595-1597 IN denotes of
T409 1598-1613 NN denotes corticosteroids
T410 1614-1616 IN denotes in
T411 1617-1620 DT denotes the
T412 1621-1630 NN denotes treatment
T413 1631-1633 IN denotes of
T414 1634-1642 JJ denotes allergic
T415 1643-1651 NN denotes diseases
T416 1654-1660 VB denotes Please
T417 1661-1664 VB denotes see
T418 1665-1670 RB denotes later
T419 1671-1673 IN denotes in
T420 1674-1677 DT denotes the
T421 1678-1685 NN denotes article
T422 1686-1689 IN denotes for
T423 1690-1697 NN denotes Editors
T424 1697-1698 POS denotes '
T425 1699-1706 JJ denotes Summary
R115 T167 T168 arg1Of GATA-3,plays
R116 T167 T173 arg1Of GATA-3,regulating
R117 T167 T198 arg1Of GATA-3,is
R118 T168 T172 arg1Of plays,in
R119 T168 T196 arg1Of plays,and
R120 T171 T168 arg2Of role,plays
R121 T171 T169 arg1Of role,a
R122 T171 T170 arg1Of role,critical
R123 T173 T172 arg2Of regulating,in
R124 T175 T173 arg2Of expression,regulating
R125 T175 T174 arg1Of expression,the
R126 T175 T176 arg1Of expression,of
R127 T175 T189 arg1Of expression,from
R128 T178 T177 arg1Of cytokines,the
R129 T179 T180 arg1Of interleukin,(
R130 T179 T183 arg1Of interleukin,-4
R131 T179 T184 arg1Of interleukin,","
R132 T181 T180 arg2Of IL,(
R133 T182 T180 arg3Of ),(
R134 T184 T187 arg1Of ",",and
R135 T185 T184 arg2Of IL-5,","
R136 T187 T176 arg2Of and,of
R137 T187 T178 arg1Of and,cytokines
R138 T187 T186 arg1Of and,","
R139 T188 T187 arg2Of IL-13,and
R140 T193 T192 arg2Of Th2,(
R141 T194 T192 arg3Of ),(
R142 T195 T189 arg2Of cells,from
R143 T195 T190 arg1Of cells,T
R144 T195 T191 arg1Of cells,helper-2
R145 T195 T192 arg1Of cells,(
R146 T198 T196 arg2Of is,and
R147 T198 T197 arg1Of is,therefore
R148 T201 T198 arg2Of mediator,is
R149 T201 T199 arg1Of mediator,a
R150 T201 T200 arg1Of mediator,key
R151 T201 T202 arg1Of mediator,of
R152 T204 T202 arg2Of diseases,of
R153 T204 T203 arg1Of diseases,allergic
R154 T205 T206 arg1Of Corticosteroids,are
R155 T205 T208 arg1Of Corticosteroids,effective
R156 T206 T214 arg1Of are,but
R157 T208 T206 arg2Of effective,are
R158 T208 T207 arg1Of effective,highly
R159 T208 T209 arg1Of effective,in
R160 T210 T209 arg2Of suppressing,in
R161 T212 T210 arg2Of inflammation,suppressing
R162 T212 T211 arg1Of inflammation,allergic
R163 T214 T213 arg1Of but,","
R164 T216 T215 arg1Of effects,their
R165 T216 T217 arg1Of effects,on
R166 T216 T219 arg1Of effects,are
R167 T216 T220 arg1Of effects,unknown
R168 T218 T217 arg2Of GATA-3,on
R169 T219 T214 arg2Of are,but
R170 T220 T219 arg2Of unknown,are
R171 T221 T222 arg1Of We,investigated
R172 T222 T237 arg1Of investigated,vitro
R173 T222 T240 arg1Of investigated,vivo
R174 T224 T222 arg2Of effect,investigated
R175 T224 T223 arg1Of effect,the
R176 T224 T225 arg1Of effect,of
R177 T224 T230 arg1Of effect,on
R178 T229 T225 arg2Of propionate,of
R179 T229 T226 arg1Of propionate,the
R180 T229 T227 arg1Of propionate,corticosteroid
R181 T229 T228 arg1Of propionate,fluticasone
R182 T232 T230 arg2Of regulation,on
R183 T232 T231 arg1Of regulation,GATA-3
R184 T232 T233 arg1Of regulation,in
R185 T235 T233 arg2Of T-lymphocytes,in
R186 T235 T234 arg1Of T-lymphocytes,human
R187 T237 T236 arg1Of vitro,in
R188 T237 T238 arg1Of vitro,and
R189 T240 T238 arg2Of vivo,and
R190 T240 T239 arg1Of vivo,in
R191 T241 T242 arg1Of Methods,and
R192 T243 T242 arg2Of Findings,and
R193 T249 T246 arg1Of line,T
R194 T249 T247 arg1Of line,lymphocyte
R195 T249 T248 arg1Of line,cell
R196 T249 T250 arg1Of line,(
R197 T249 T253 arg1Of line,and
R198 T251 T250 arg2Of HuT-78,(
R199 T252 T250 arg3Of ),(
R200 T253 T244 arg2Of and,In
R201 T253 T245 arg1Of and,a
R202 T253 T264 arg1Of and,vitro
R203 T257 T253 arg2Of cells,and
R204 T257 T254 arg1Of cells,peripheral
R205 T257 T255 arg1Of cells,blood
R206 T257 T256 arg1Of cells,mononuclear
R207 T257 T258 arg2Of cells,stimulated
R208 T260 T261 arg1Of anti-CD3,and
R209 T261 T258 arg1Of and,stimulated
R210 T261 T259 arg2Of and,by
R211 T262 T261 arg2Of anti-CD28,and
R212 T264 T263 arg1Of vitro,in
R213 T265 T266 arg1Of we,demonstrated
R214 T266 T244 arg1Of demonstrated,In
R215 T268 T269 arg1Of fluticasone,inhibits
R216 T268 T287 arg1Of fluticasone,is
R217 T268 T288 arg1Of fluticasone,due
R218 T269 T279 arg1Of inhibits,via
R219 T269 T286 arg1Of inhibits,and
R220 T271 T270 arg1Of translocation,nuclear
R221 T271 T272 arg1Of translocation,of
R222 T271 T274 arg1Of translocation,and
R223 T273 T272 arg2Of GATA-3,of
R224 T274 T269 arg2Of and,inhibits
R225 T275 T274 arg2Of expression,and
R226 T275 T276 arg1Of expression,of
R227 T278 T276 arg2Of cytokines,of
R228 T278 T277 arg1Of cytokines,Th2
R229 T281 T279 arg2Of mechanism,via
R230 T281 T280 arg1Of mechanism,a
R231 T281 T282 arg1Of mechanism,independent
R232 T282 T283 arg1Of independent,of
R233 T285 T283 arg2Of factor-κB,of
R234 T285 T284 arg1Of factor-κB,nuclear
R235 T286 T266 arg2Of and,demonstrated
R236 T286 T267 arg1Of and,that
R237 T287 T286 arg2Of is,and
R238 T287 T292 arg1Of is,","
R239 T287 T293 arg1Of is,to
R240 T288 T287 arg2Of due,is
R241 T288 T289 arg1Of due,","
R242 T288 T290 arg1Of due,in
R243 T291 T290 arg2Of part,in
R244 T294 T293 arg2Of competition,to
R245 T294 T295 arg1Of competition,between
R246 T296 T297 arg1Of GATA-3,and
R247 T297 T295 arg2Of and,between
R248 T301 T297 arg2Of receptor,and
R249 T301 T298 arg1Of receptor,the
R250 T301 T299 arg1Of receptor,ligand-activated
R251 T301 T300 arg1Of receptor,glucocorticoid
R252 T353 T348 arg2Of and,are
R253 T353 T352 arg1Of and,","
R254 T301 T302 arg1Of receptor,for
R255 T301 T305 arg1Of receptor,through
R256 T304 T302 arg2Of transport,for
R257 T354 T353 arg2Of prolonged,and
R258 T355 T357 arg1Of We,demonstrated
R259 T357 T356 arg1Of demonstrated,also
R260 T360 T359 arg2Of fluticasone,inhaled
R261 T360 T361 arg1Of fluticasone,inhibits
R262 T304 T303 arg1Of transport,nuclear
R263 T361 T357 arg2Of inhibits,demonstrated
R264 T361 T358 arg1Of inhibits,that
R265 T309 T305 arg2Of importin-α,through
R266 T364 T361 arg2Of translocation,inhibits
R267 T364 T362 arg1Of translocation,GATA-3
R268 T364 T363 arg1Of translocation,nuclear
R269 T364 T365 arg1Of translocation,in
R270 T368 T365 arg2Of lymphocytes,in
R271 T368 T366 arg1Of lymphocytes,peripheral
R272 T368 T367 arg1Of lymphocytes,blood
R273 T368 T369 arg1Of lymphocytes,of
R274 T370 T369 arg2Of patients,of
R275 T370 T371 arg1Of patients,with
R276 T309 T306 arg1Of importin-α,the
R277 T372 T371 arg2Of asthma,with
R278 T372 T374 arg1Of asthma,vivo
R279 T309 T307 arg1Of importin-α,nuclear
R280 T309 T308 arg1Of importin-α,importer
R281 T374 T373 arg1Of vivo,in
R282 T311 T310 arg2Of addition,In
R283 T376 T377 arg1Of Corticosteroids,have
R284 T377 T384 arg1Of have,via
R285 T313 T314 arg1Of fluticasone,induces
R286 T380 T379 arg1Of inhibitory,potent
R287 T381 T377 arg2Of effect,have
R288 T381 T378 arg1Of effect,a
R289 T381 T380 arg1Of effect,inhibitory
R290 T314 T310 arg1Of induces,In
R291 T381 T382 arg1Of effect,on
R292 T383 T382 arg2Of GATA-3,on
R293 T314 T312 arg1Of induces,","
R294 T316 T314 arg2Of expression,induces
R295 T387 T384 arg2Of mechanisms,via
R296 T387 T385 arg1Of mechanisms,two
R297 T387 T386 arg1Of mechanisms,interacting
R298 T387 T388 arg1Of mechanisms,that
R299 T387 T390 arg1Of mechanisms,suppress
R300 T390 T389 arg1Of suppress,potently
R301 T316 T315 arg1Of expression,the
R302 T316 T317 arg1Of expression,of
R303 T320 T318 arg1Of kinase,mitogen-activated
R304 T393 T390 arg2Of expression,suppress
R305 T393 T391 arg1Of expression,Th2
R306 T393 T392 arg1Of expression,cytokine
R307 T396 T394 arg1Of mechanism,This
R308 T396 T395 arg1Of mechanism,novel
R309 T396 T397 arg1Of mechanism,of
R310 T396 T401 arg1Of mechanism,may
R311 T396 T402 arg1Of mechanism,account
R312 T398 T397 arg2Of action,of
R313 T398 T399 arg1Of action,of
R314 T400 T399 arg2Of corticosteroids,of
R315 T402 T401 arg2Of account,may
R316 T402 T403 arg1Of account,for
R317 T320 T319 arg1Of kinase,protein
R318 T320 T321 arg1Of kinase,(
R319 T322 T321 arg2Of MAPK,(
R320 T407 T403 arg2Of efficacy,for
R321 T407 T404 arg1Of efficacy,the
R322 T407 T405 arg1Of efficacy,striking
R323 T407 T406 arg1Of efficacy,clinical
R324 T407 T408 arg1Of efficacy,of
R325 T407 T410 arg1Of efficacy,in
R326 T409 T408 arg2Of corticosteroids,of
R327 T323 T321 arg3Of ),(
R328 T412 T410 arg2Of treatment,in
R329 T412 T411 arg1Of treatment,the
R330 T412 T413 arg1Of treatment,of
R331 T324 T317 arg2Of phosphatase-1,of
R332 T415 T413 arg2Of diseases,of
R333 T415 T414 arg1Of diseases,allergic
R334 T417 T416 arg1Of see,Please
R335 T324 T320 arg1Of phosphatase-1,kinase
R336 T324 T325 arg1Of phosphatase-1,(
R337 T324 T328 arg1Of phosphatase-1,","
R338 T326 T325 arg2Of MKP-1,(
R339 T327 T325 arg3Of ),(
R340 T331 T328 arg2Of inhibitor,","
R341 T417 T418 arg1Of see,later
R342 T331 T329 arg1Of inhibitor,the
R343 T331 T330 arg1Of inhibitor,endogenous
R344 T331 T332 arg1Of inhibitor,of
R345 T334 T332 arg2Of MAPK,of
R346 T334 T333 arg1Of MAPK,p38
R347 T334 T335 arg1Of MAPK,","
R348 T334 T336 arg1Of MAPK,which
R349 T334 T337 arg1Of MAPK,is
R350 T334 T338 arg1Of MAPK,necessary
R351 T338 T337 arg2Of necessary,is
R352 T417 T419 arg1Of see,in
R353 T338 T339 arg1Of necessary,for
R354 T342 T339 arg2Of translocation,for
R355 T421 T419 arg2Of article,in
R356 T421 T420 arg1Of article,the
R357 T421 T422 arg1Of article,for
R358 T423 T422 arg2Of Editors,for
R359 T424 T417 arg2Of ',see
R360 T424 T425 arg1Of ',Summary
R361 T342 T340 arg1Of translocation,GATA-3
R362 T342 T341 arg1Of translocation,nuclear
R363 T345 T343 arg1Of effects,These
R364 T345 T344 arg1Of effects,inhibitory
R365 T345 T346 arg1Of effects,of
R366 T345 T348 arg1Of effects,are
R367 T345 T349 arg1Of effects,rapid
R368 T345 T351 arg1Of effects,potent
R369 T345 T354 arg1Of effects,prolonged
R370 T347 T346 arg2Of fluticasone,of
R371 T349 T350 arg1Of rapid,","
R372 T350 T353 arg1Of ",",and
R373 T351 T350 arg2Of potent,","

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T426 72-85 Anaphor denotes the cytokines
T427 86-104 Antecedent denotes interleukin (IL)-4
T428 106-110 Antecedent denotes IL-5
T429 116-121 Antecedent denotes IL-13
R768 T426 T427 boundBy the cytokines,interleukin (IL)-4
R777 T426 T428 boundBy the cytokines,IL-5
R778 T426 T429 boundBy the cytokines,IL-13

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T477 40-42 IN denotes in
T478 43-53 VBG denotes regulating
T479 54-57 DT denotes the
T480 58-68 NN denotes expression
T481 69-71 IN denotes of
T482 72-75 DT denotes the
T483 76-85 NNS denotes cytokines
T484 86-97 VBP denotes interleukin
T485 98-99 -LRB- denotes (
T486 99-101 NNP denotes IL
T487 101-102 -RRB- denotes )
T488 102-104 CD denotes -4
T489 104-105 , denotes ,
T490 106-110 NN denotes IL-5
T491 110-111 , denotes ,
T492 112-115 CC denotes and
T493 116-121 NN denotes IL-13
T494 122-126 IN denotes from
T495 127-128 NNP denotes T
T496 129-137 JJ denotes helper-2
T497 138-139 -LRB- denotes (
T498 139-142 JJ denotes Th2
T499 142-143 -RRB- denotes )
T500 144-149 NNS denotes cells
T501 150-153 CC denotes and
T502 154-163 RB denotes therefore
T503 164-166 VBZ denotes is
T504 167-168 DT denotes a
T505 169-172 JJ denotes key
T506 173-181 NN denotes mediator
T507 182-184 IN denotes of
T508 185-193 JJ denotes allergic
T509 194-202 NNS denotes diseases
T510 202-203 . denotes .
T511 204-219 NNS denotes Corticosteroids
T512 220-223 VBP denotes are
T513 224-230 RB denotes highly
T514 231-240 JJ denotes effective
T515 241-243 IN denotes in
T516 244-255 VBG denotes suppressing
T517 256-264 JJ denotes allergic
T518 265-277 NN denotes inflammation
T519 277-278 , denotes ,
T520 279-282 CC denotes but
T521 283-288 PRP$ denotes their
T522 289-296 NNS denotes effects
T523 297-299 IN denotes on
T524 300-306 NN denotes GATA-3
T525 307-310 VBP denotes are
T526 311-318 JJ denotes unknown
T527 318-319 . denotes .
T528 320-322 PRP denotes We
T529 323-335 VBD denotes investigated
T530 336-339 DT denotes the
T531 340-346 NN denotes effect
T532 347-349 IN denotes of
T533 350-353 DT denotes the
T534 354-368 JJ denotes corticosteroid
T535 369-380 NN denotes fluticasone
T536 381-391 NN denotes propionate
T537 392-394 IN denotes on
T538 395-401 JJ denotes GATA-3
T539 402-412 NN denotes regulation
T540 413-415 IN denotes in
T541 416-421 JJ denotes human
T542 422-435 NNS denotes T-lymphocytes
T543 436-438 IN denotes in
T544 439-444 NN denotes vitro
T545 445-448 CC denotes and
T546 449-451 IN denotes in
T547 452-456 NN denotes vivo
T548 456-457 . denotes .
T549 459-466 NNS denotes Methods
T550 467-470 CC denotes and
T551 471-479 NNS denotes Findings
T552 480-482 IN denotes In
T553 483-484 DT denotes a
T554 485-486 NNP denotes T
T555 487-497 NN denotes lymphocyte
T556 498-502 NN denotes cell
T557 503-507 NN denotes line
T558 508-509 -LRB- denotes (
T559 509-515 JJ denotes HuT-78
T560 515-516 -RRB- denotes )
T561 517-520 CC denotes and
T562 521-531 JJ denotes peripheral
T563 532-537 NN denotes blood
T564 538-549 NN denotes mononuclear
T565 550-555 NNS denotes cells
T566 556-566 VBN denotes stimulated
T567 567-569 IN denotes by
T568 570-578 JJ denotes anti-CD3
T569 579-582 CC denotes and
T570 583-592 JJ denotes anti-CD28
T571 593-595 IN denotes in
T572 596-601 NN denotes vitro
T573 602-604 PRP denotes we
T574 605-617 VBD denotes demonstrated
T575 618-622 IN denotes that
T576 623-634 NN denotes fluticasone
T577 635-643 NNS denotes inhibits
T578 644-651 JJ denotes nuclear
T579 652-665 NN denotes translocation
T580 666-668 IN denotes of
T581 669-675 NNP denotes GATA-3
T582 676-679 CC denotes and
T583 680-690 NN denotes expression
T584 691-693 IN denotes of
T585 694-697 JJ denotes Th2
T586 698-707 NNS denotes cytokines
T587 708-711 IN denotes via
T588 712-713 DT denotes a
T589 714-723 NN denotes mechanism
T590 724-735 JJ denotes independent
T591 736-738 IN denotes of
T592 739-746 JJ denotes nuclear
T593 747-756 NN denotes factor-κB
T594 757-760 CC denotes and
T595 761-763 VBZ denotes is
T596 764-767 JJ denotes due
T597 767-768 , denotes ,
T598 769-771 IN denotes in
T599 772-776 NN denotes part
T600 776-777 , denotes ,
T601 778-780 TO denotes to
T602 781-792 NN denotes competition
T603 793-800 IN denotes between
T604 801-807 NNP denotes GATA-3
T605 808-811 CC denotes and
T606 812-815 DT denotes the
T607 816-832 JJ denotes ligand-activated
T608 833-847 NN denotes glucocorticoid
T609 848-856 NN denotes receptor
T610 857-860 IN denotes for
T611 861-868 JJ denotes nuclear
T612 869-878 NN denotes transport
T613 879-886 IN denotes through
T614 887-890 DT denotes the
T615 891-898 JJ denotes nuclear
T616 899-907 NN denotes importer
T617 908-918 NN denotes importin-α
T618 918-919 . denotes .
T619 920-922 IN denotes In
T620 923-931 NN denotes addition
T621 931-932 , denotes ,
T622 933-944 NN denotes fluticasone
T623 945-952 VBZ denotes induces
T624 953-956 DT denotes the
T625 957-967 NN denotes expression
T626 968-970 IN denotes of
T627 971-988 JJ denotes mitogen-activated
T628 989-996 NN denotes protein
T629 997-1003 NN denotes kinase
T630 1004-1005 -LRB- denotes (
T631 1005-1009 NNP denotes MAPK
T632 1009-1010 -RRB- denotes )
T633 1011-1024 JJ denotes phosphatase-1
T634 1025-1026 -LRB- denotes (
T635 1026-1031 NNP denotes MKP-1
T636 1031-1032 -RRB- denotes )
T637 1032-1033 , denotes ,
T638 1034-1037 DT denotes the
T639 1038-1048 JJ denotes endogenous
T640 1049-1058 NN denotes inhibitor
T641 1059-1061 IN denotes of
T642 1062-1065 CD denotes p38
T643 1066-1070 NNP denotes MAPK
T644 1070-1071 , denotes ,
T645 1072-1077 WDT denotes which
T646 1078-1080 VBZ denotes is
T647 1081-1090 JJ denotes necessary
T648 1091-1094 IN denotes for
T649 1095-1101 JJ denotes GATA-3
T650 1102-1109 JJ denotes nuclear
T651 1110-1123 NN denotes translocation
T652 1123-1124 . denotes .
T653 1125-1130 DT denotes These
T654 1131-1141 JJ denotes inhibitory
T655 1142-1149 NNS denotes effects
T656 1150-1152 IN denotes of
T657 1153-1164 NN denotes fluticasone
T658 1165-1168 VBP denotes are
T659 1169-1174 JJ denotes rapid
T660 1174-1175 , denotes ,
T661 1176-1182 JJ denotes potent
T662 1182-1183 , denotes ,
T663 1184-1187 CC denotes and
T664 1188-1197 VBN denotes prolonged
T665 1197-1198 . denotes .
T666 1199-1201 PRP denotes We
T667 1202-1206 RB denotes also
T668 1207-1219 VBD denotes demonstrated
T669 1220-1224 IN denotes that
T670 1225-1232 JJ denotes inhaled
T671 1233-1244 NN denotes fluticasone
T672 1245-1253 VBZ denotes inhibits
T673 1254-1260 JJ denotes GATA-3
T674 1261-1268 JJ denotes nuclear
T675 1269-1282 NN denotes translocation
T676 1283-1285 IN denotes in
T677 1286-1296 JJ denotes peripheral
T678 1297-1302 NN denotes blood
T679 1303-1314 NNS denotes lymphocytes
T680 1315-1317 IN denotes of
T681 1318-1326 NNS denotes patients
T682 1327-1331 IN denotes with
T683 1332-1338 NN denotes asthma
T684 1339-1341 IN denotes in
T685 1342-1346 NN denotes vivo
T686 1346-1347 . denotes .
T687 1349-1360 NNS denotes Conclusions
T688 1361-1376 NNS denotes Corticosteroids
T689 1377-1381 VBP denotes have
T690 1382-1383 DT denotes a
T691 1384-1390 JJ denotes potent
T692 1391-1401 JJ denotes inhibitory
T693 1402-1408 NN denotes effect
T694 1409-1411 IN denotes on
T695 1412-1418 JJ denotes GATA-3
T696 1419-1422 IN denotes via
T697 1423-1426 CD denotes two
T698 1427-1438 VBG denotes interacting
T699 1439-1449 NNS denotes mechanisms
T700 1450-1454 WDT denotes that
T701 1455-1463 RB denotes potently
T702 1464-1472 VBP denotes suppress
T703 1473-1476 JJ denotes Th2
T704 1477-1485 NN denotes cytokine
T705 1486-1496 NN denotes expression
T706 1496-1497 . denotes .
T707 1498-1502 DT denotes This
T708 1503-1508 NN denotes novel
T709 1509-1518 NN denotes mechanism
T710 1519-1521 IN denotes of
T711 1522-1528 NN denotes action
T712 1529-1531 IN denotes of
T713 1532-1547 NNS denotes corticosteroids
T714 1548-1551 MD denotes may
T715 1552-1559 VB denotes account
T716 1560-1563 IN denotes for
T717 1564-1567 DT denotes the
T718 1568-1576 JJ denotes striking
T719 1577-1585 JJ denotes clinical
T720 1586-1594 NN denotes efficacy
T721 1595-1597 IN denotes of
T722 1598-1613 NNS denotes corticosteroids
T723 1614-1616 IN denotes in
T724 1617-1620 DT denotes the
T725 1621-1630 NN denotes treatment
T726 1631-1633 IN denotes of
T727 1634-1642 JJ denotes allergic
T728 1643-1651 NNS denotes diseases
T729 1651-1652 . denotes .
T730 1654-1660 VB denotes Please
T731 1661-1664 VB denotes see
T732 1665-1670 RB denotes later
T733 1671-1673 IN denotes in
T734 1674-1677 DT denotes the
T735 1678-1685 NN denotes article
T736 1686-1689 IN denotes for
T737 1690-1697 NNS denotes Editors
T738 1697-1698 POS denotes '
T739 1699-1706 NN denotes Summary
T471 0-10 NNP denotes Background
T472 11-17 NNP denotes GATA-3
T473 18-23 VBZ denotes plays
T474 24-25 DT denotes a
T475 26-34 JJ denotes critical
T476 35-39 NN denotes role
R374 T484 T488 nmod interleukin,-4
R375 T477 T476 prep in,role
R376 T478 T477 pcomp regulating,in
R377 T479 T480 det the,expression
R378 T480 T478 dobj expression,regulating
R379 T485 T484 punct (,interleukin
R380 T481 T480 prep of,expression
R381 T482 T483 det the,cytokines
R382 T483 T481 pobj cytokines,of
R383 T486 T484 appos IL,interleukin
R384 T487 T484 punct ),interleukin
R385 T488 T473 npadvmod -4,plays
R386 T489 T488 punct ",",-4
R387 T490 T488 conj IL-5,-4
R398 T590 T589 amod independent,mechanism
R400 T591 T590 prep of,independent
R401 T592 T593 amod nuclear,factor-κB
R403 T593 T591 pobj factor-κB,of
R404 T594 T577 cc and,inhibits
R405 T595 T577 conj is,inhibits
R436 T516 T515 pcomp suppressing,in
R444 T517 T518 amod allergic,inflammation
R446 T621 T623 punct ",",induces
R447 T622 T623 nsubj fluticasone,induces
R448 T518 T516 dobj inflammation,suppressing
R449 T623 T623 ROOT induces,induces
R450 T624 T625 det the,expression
R451 T625 T623 dobj expression,induces
R452 T519 T512 punct ",",are
R453 T626 T625 prep of,expression
R454 T627 T629 amod mitogen-activated,kinase
R455 T628 T629 compound protein,kinase
R456 T520 T512 cc but,are
R457 T629 T626 pobj kinase,of
R458 T630 T631 punct (,MAPK
R459 T631 T629 appos MAPK,kinase
R460 T632 T629 punct ),kinase
R461 T633 T625 appos phosphatase-1,expression
R462 T634 T633 punct (,phosphatase-1
R463 T521 T522 poss their,effects
R464 T635 T633 appos MKP-1,phosphatase-1
R465 T636 T633 punct ),phosphatase-1
R466 T637 T633 punct ",",phosphatase-1
R467 T522 T525 nsubj effects,are
R468 T638 T640 det the,inhibitor
R469 T639 T640 amod endogenous,inhibitor
R470 T640 T633 appos inhibitor,phosphatase-1
R471 T523 T522 prep on,effects
R472 T641 T640 prep of,inhibitor
R473 T642 T643 nummod p38,MAPK
R474 T524 T523 pobj GATA-3,on
R475 T643 T641 pobj MAPK,of
R476 T644 T643 punct ",",MAPK
R477 T645 T646 nsubj which,is
R478 T646 T643 relcl is,MAPK
R479 T525 T512 conj are,are
R480 T647 T646 acomp necessary,is
R481 T648 T647 prep for,necessary
R482 T526 T525 acomp unknown,are
R483 T527 T525 punct .,are
R484 T528 T529 nsubj We,investigated
R485 T529 T529 ROOT investigated,investigated
R486 T649 T651 amod GATA-3,translocation
R487 T530 T531 det the,effect
R488 T531 T529 dobj effect,investigated
R489 T532 T531 prep of,effect
R490 T533 T536 det the,propionate
R491 T534 T536 amod corticosteroid,propionate
R492 T650 T651 amod nuclear,translocation
R493 T535 T536 compound fluticasone,propionate
R494 T536 T532 pobj propionate,of
R495 T537 T536 prep on,propionate
R496 T538 T539 amod GATA-3,regulation
R497 T539 T537 pobj regulation,on
R498 T540 T539 prep in,regulation
R499 T651 T648 pobj translocation,for
R500 T541 T542 amod human,T-lymphocytes
R501 T542 T540 pobj T-lymphocytes,in
R502 T543 T539 prep in,regulation
R503 T544 T543 pobj vitro,in
R504 T545 T543 cc and,in
R506 T546 T543 conj in,in
R508 T547 T546 pobj vivo,in
R511 T548 T529 punct .,investigated
R512 T549 T549 ROOT Methods,Methods
R514 T550 T549 cc and,Methods
R518 T551 T549 conj Findings,Methods
R522 T552 T574 prep In,demonstrated
R526 T553 T557 det a,line
R529 T554 T557 compound T,line
R534 T555 T557 compound lymphocyte,line
R537 T556 T557 compound cell,line
R541 T557 T552 pobj line,In
R545 T558 T559 punct (,HuT-78
R548 T559 T565 amod HuT-78,cells
R550 T560 T559 punct ),HuT-78
R551 T561 T559 cc and,HuT-78
R552 T562 T565 amod peripheral,cells
R553 T563 T564 compound blood,mononuclear
R556 T564 T565 compound mononuclear,cells
R562 T565 T574 nsubj cells,demonstrated
R565 T566 T565 acl stimulated,cells
R569 T567 T566 agent by,stimulated
R572 T568 T574 advcl anti-CD3,demonstrated
R573 T569 T568 cc and,anti-CD3
R574 T570 T568 conj anti-CD28,anti-CD3
R575 T571 T574 prep in,demonstrated
R577 T572 T571 pobj vitro,in
R581 T573 T574 nsubj we,demonstrated
R584 T574 T574 ROOT demonstrated,demonstrated
R588 T575 T577 mark that,inhibits
R592 T576 T577 nsubj fluticasone,inhibits
R596 T577 T574 ccomp inhibits,demonstrated
R600 T578 T579 amod nuclear,translocation
R603 T579 T577 dobj translocation,inhibits
R604 T717 T720 det the,efficacy
R605 T580 T579 prep of,translocation
R606 T581 T580 pobj GATA-3,of
R607 T582 T579 cc and,translocation
R608 T583 T579 conj expression,translocation
R609 T584 T583 prep of,expression
R610 T585 T586 amod Th2,cytokines
R611 T586 T584 pobj cytokines,of
R612 T718 T720 amod striking,efficacy
R613 T587 T577 prep via,inhibits
R614 T719 T720 amod clinical,efficacy
R615 T720 T716 pobj efficacy,for
R616 T588 T589 det a,mechanism
R617 T721 T720 prep of,efficacy
R618 T722 T721 pobj corticosteroids,of
R619 T589 T587 pobj mechanism,via
R620 T723 T722 prep in,corticosteroids
R621 T724 T725 det the,treatment
R622 T725 T723 pobj treatment,in
R624 T726 T725 prep of,treatment
R625 T727 T728 amod allergic,diseases
R796 T471 T472 compound Background,GATA-3
R797 T472 T473 nsubj GATA-3,plays
R798 T473 T473 ROOT plays,plays
R799 T474 T476 det a,role
R800 T475 T476 amod critical,role
R801 T476 T473 dobj role,plays
R434 T611 T612 amod nuclear,transport
R435 T612 T610 pobj transport,for
R437 T613 T610 prep through,for
R438 T614 T616 det the,importer
R439 T615 T616 amod nuclear,importer
R440 T616 T613 pobj importer,through
R441 T617 T609 conj importin-α,receptor
R442 T618 T574 punct .,demonstrated
R443 T619 T623 prep In,induces
R445 T620 T619 pobj addition,In
R505 T652 T623 punct .,induces
R507 T653 T655 det These,effects
R509 T654 T655 amod inhibitory,effects
R510 T655 T658 nsubj effects,are
R513 T656 T655 prep of,effects
R515 T657 T656 pobj fluticasone,of
R516 T658 T658 ROOT are,are
R517 T659 T658 acomp rapid,are
R519 T660 T659 punct ",",rapid
R520 T661 T659 conj potent,rapid
R521 T662 T658 punct ",",are
R523 T663 T658 cc and,are
R524 T664 T658 conj prolonged,are
R525 T665 T658 punct .,are
R527 T666 T668 nsubj We,demonstrated
R528 T667 T668 advmod also,demonstrated
R530 T668 T668 ROOT demonstrated,demonstrated
R531 T669 T672 mark that,inhibits
R532 T670 T671 amod inhaled,fluticasone
R533 T671 T672 nsubj fluticasone,inhibits
R535 T672 T668 ccomp inhibits,demonstrated
R536 T673 T675 amod GATA-3,translocation
R538 T674 T675 amod nuclear,translocation
R539 T675 T672 dobj translocation,inhibits
R540 T676 T675 prep in,translocation
R542 T677 T679 amod peripheral,lymphocytes
R543 T678 T679 compound blood,lymphocytes
R544 T679 T676 pobj lymphocytes,in
R546 T680 T679 prep of,lymphocytes
R547 T681 T680 pobj patients,of
R549 T682 T672 prep with,inhibits
R554 T683 T682 pobj asthma,with
R555 T684 T683 prep in,asthma
R557 T685 T684 pobj vivo,in
R558 T686 T668 punct .,demonstrated
R559 T687 T688 compound Conclusions,Corticosteroids
R560 T688 T689 nsubj Corticosteroids,have
R561 T689 T689 ROOT have,have
R563 T690 T693 det a,effect
R564 T691 T693 amod potent,effect
R566 T692 T693 amod inhibitory,effect
R567 T693 T689 dobj effect,have
R568 T694 T693 prep on,effect
R570 T695 T694 pobj GATA-3,on
R571 T696 T689 prep via,have
R576 T697 T699 nummod two,mechanisms
R578 T698 T699 amod interacting,mechanisms
R579 T699 T696 pobj mechanisms,via
R580 T700 T702 nsubj that,suppress
R582 T701 T702 advmod potently,suppress
R583 T702 T699 relcl suppress,mechanisms
R585 T703 T705 amod Th2,expression
R586 T704 T705 amod cytokine,expression
R587 T705 T702 dobj expression,suppress
R589 T706 T689 punct .,have
R590 T707 T709 det This,mechanism
R591 T708 T709 amod novel,mechanism
R593 T709 T715 nsubj mechanism,account
R594 T710 T709 prep of,mechanism
R595 T711 T710 pobj action,of
R597 T712 T711 prep of,action
R598 T713 T712 pobj corticosteroids,of
R599 T714 T715 aux may,account
R601 T715 T715 ROOT account,account
R602 T716 T715 prep for,account
R388 T491 T490 punct ",",IL-5
R389 T492 T490 cc and,IL-5
R390 T493 T490 conj IL-13,IL-5
R391 T494 T490 prep from,IL-5
R392 T495 T496 compound T,helper-2
R393 T496 T494 pobj helper-2,from
R394 T497 T496 punct (,helper-2
R395 T498 T496 appos Th2,helper-2
R396 T499 T496 punct ),helper-2
R397 T500 T494 pobj cells,from
R399 T501 T473 cc and,plays
R402 T502 T503 advmod therefore,is
R406 T503 T473 conj is,plays
R407 T504 T506 det a,mediator
R408 T505 T506 amod key,mediator
R409 T506 T503 attr mediator,is
R410 T507 T506 prep of,mediator
R411 T508 T509 amod allergic,diseases
R412 T509 T507 pobj diseases,of
R413 T510 T473 punct .,plays
R417 T511 T512 nsubj Corticosteroids,are
R420 T512 T512 ROOT are,are
R424 T513 T514 advmod highly,effective
R427 T514 T512 acomp effective,are
R431 T515 T514 prep in,effective
R414 T596 T595 acomp due,is
R415 T597 T595 punct ",",is
R416 T598 T595 prep in,is
R418 T599 T598 pobj part,in
R419 T600 T595 punct ",",is
R421 T601 T577 prep to,inhibits
R422 T602 T601 pobj competition,to
R423 T603 T602 prep between,competition
R425 T604 T603 pobj GATA-3,between
R426 T605 T604 cc and,GATA-3
R428 T606 T609 det the,receptor
R429 T607 T609 amod ligand-activated,receptor
R430 T608 T609 compound glucocorticoid,receptor
R432 T609 T604 conj receptor,GATA-3
R433 T610 T609 prep for,receptor
R626 T728 T726 pobj diseases,of
R627 T729 T715 punct .,account
R628 T730 T731 intj Please,see
R629 T731 T731 ROOT see,see
R630 T732 T731 advmod later,see
R631 T733 T732 prep in,later
R633 T734 T735 det the,article
R634 T735 T733 pobj article,in
R635 T736 T735 prep for,article
R636 T737 T739 poss Editors,Summary
R638 T738 T737 case ',Editors
R639 T739 T736 pobj Summary,for

UBERON-AE

Id Subject Object Predicate Lexical cue
T87 532-537 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T88 1297-1302 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

GO-BP

Id Subject Object Predicate Lexical cue
T757 265-277 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T758 402-412 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T759 833-868 http://purl.obolibrary.org/obo/GO_0002147 denotes glucocorticoid receptor for nuclear
T760 861-878 http://purl.obolibrary.org/obo/GO_0051169 denotes nuclear transport
T761 869-878 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T762 979-1003 http://purl.obolibrary.org/obo/GO_0034199 denotes activated protein kinase
T763 979-1003 http://purl.obolibrary.org/obo/GO_0032147 denotes activated protein kinase
T764 979-1003 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T765 979-1003 http://purl.obolibrary.org/obo/GO_0032111 denotes activated protein kinase
T766 1005-1009 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T767 1062-1065 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T768 1011-1022 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T755 891-907 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear importer

GO-MF

Id Subject Object Predicate Lexical cue
T770 99-104 http://purl.obolibrary.org/obo/GO_0005136 denotes IL)-4
T771 106-110 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T772 116-121 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T773 816-822 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T774 979-1003 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T775 1005-1009 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T776 1062-1065 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T777 1011-1022 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase

GO-CC

Id Subject Object Predicate Lexical cue
T778 144-149 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T779 550-555 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T136 0-10 Sentence denotes Background
T137 11-203 Sentence denotes GATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases.
T138 204-319 Sentence denotes Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown.
T139 320-457 Sentence denotes We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.
T140 459-479 Sentence denotes Methods and Findings
T141 480-919 Sentence denotes In a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α.
T142 920-1124 Sentence denotes In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation.
T143 1125-1198 Sentence denotes These inhibitory effects of fluticasone are rapid, potent, and prolonged.
T144 1199-1347 Sentence denotes We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo.
T145 1349-1360 Sentence denotes Conclusions
T146 1361-1497 Sentence denotes Corticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that potently suppress Th2 cytokine expression.
T147 1498-1652 Sentence denotes This novel mechanism of action of corticosteroids may account for the striking clinical efficacy of corticosteroids in the treatment of allergic diseases.
T148 1654-1706 Sentence denotes Please see later in the article for Editors' Summary
T6 0-10 Sentence denotes Background
T7 11-203 Sentence denotes GATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases.
T8 204-319 Sentence denotes Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown.
T9 320-457 Sentence denotes We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.
T10 459-479 Sentence denotes Methods and Findings
T11 480-919 Sentence denotes In a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α.
T12 920-1124 Sentence denotes In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation.
T13 1125-1198 Sentence denotes These inhibitory effects of fluticasone are rapid, potent, and prolonged.
T14 1199-1347 Sentence denotes We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo.
T15 1349-1360 Sentence denotes Conclusions
T16 1361-1497 Sentence denotes Corticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that potently suppress Th2 cytokine expression.
T17 1498-1652 Sentence denotes This novel mechanism of action of corticosteroids may account for the striking clinical efficacy of corticosteroids in the treatment of allergic diseases.
T18 1654-1706 Sentence denotes Please see later in the article for Editors' Summary

ICD10

Id Subject Object Predicate Lexical cue
T780 1332-1338 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T769 1332-1338 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma

events-check-again

Id Subject Object Predicate Lexical cue
T879 11-17 Protein denotes GATA-3
T880 43-53 Regulation denotes regulating
T881 43-53 Regulation denotes regulating
T882 43-53 Regulation denotes regulating
T883 58-68 Gene_expression denotes expression
T884 58-68 Gene_expression denotes expression
T885 58-68 Gene_expression denotes expression
T886 86-104 Protein denotes interleukin (IL)-4
T887 106-110 Protein denotes IL-5
T888 116-121 Protein denotes IL-13
T889 300-306 Protein denotes GATA-3
T890 340-346 Regulation denotes effect
T891 395-401 Protein denotes GATA-3
T892 402-412 Regulation denotes regulation
T893 635-643 Negative_regulation denotes inhibits
T894 644-651 Entity denotes nuclear
T895 652-665 Localization denotes translocation
T896 669-675 Protein denotes GATA-3
T897 781-792 Negative_regulation denotes competition
T898 781-792 Negative_regulation denotes competition
T899 801-807 Protein denotes GATA-3
T900 823-832 Positive_regulation denotes activated
T901 833-856 Protein denotes glucocorticoid receptor
T902 861-868 Entity denotes nuclear
T903 869-878 Localization denotes transport
T904 869-878 Localization denotes transport
T905 945-952 Positive_regulation denotes induces
T906 957-967 Gene_expression denotes expression
T907 971-1024 Protein denotes mitogen-activated protein kinase (MAPK) phosphatase-1
T908 1026-1031 Protein denotes MKP-1
T909 1081-1090 Positive_regulation denotes necessary
T910 1095-1101 Protein denotes GATA-3
T911 1102-1109 Entity denotes nuclear
T912 1110-1123 Localization denotes translocation
T913 1245-1253 Negative_regulation denotes inhibits
T914 1254-1260 Protein denotes GATA-3
T915 1261-1268 Entity denotes nuclear
T916 1269-1282 Localization denotes translocation
T917 1391-1408 Negative_regulation denotes inhibitory effect
T918 1412-1418 Protein denotes GATA-3
R684 T884 T882 themeOf expression,regulating
R686 T885 T881 themeOf expression,regulating
R688 T886 T884 themeOf interleukin (IL)-4,expression
R689 T887 T883 themeOf IL-5,expression
R690 T888 T885 themeOf IL-13,expression
R692 T891 T892 themeOf GATA-3,regulation
R694 T892 T890 themeOf regulation,effect
R695 T894 T895 locationOf nuclear,translocation
R696 T895 T893 themeOf translocation,inhibits
R697 T896 T895 themeOf GATA-3,translocation
R704 T899 T904 themeOf GATA-3,transport
R707 T901 T903 themeOf glucocorticoid receptor,transport
R708 T901 T900 themeOf glucocorticoid receptor,activated
R709 T902 T904 locationOf nuclear,transport
R710 T902 T903 locationOf nuclear,transport
R712 T903 T897 themeOf transport,competition
R714 T904 T898 themeOf transport,competition
R715 T906 T905 themeOf expression,induces
R716 T907 T906 themeOf mitogen-activated protein kinase (MAPK) phosphatase-1,expression
R717 T908 T907 equivalentTo MKP-1,mitogen-activated protein kinase (MAPK) phosphatase-1
R718 T910 T912 themeOf GATA-3,translocation
R720 T911 T912 locationOf nuclear,translocation
R722 T912 T909 themeOf translocation,necessary
R723 T914 T916 themeOf GATA-3,translocation
R724 T915 T916 locationOf nuclear,translocation
R725 T916 T913 themeOf translocation,inhibits
R727 T918 T917 themeOf GATA-3,inhibitory effect
R760 T879 T882 causeOf GATA-3,regulating
R762 T879 T880 causeOf GATA-3,regulating
R763 T879 T881 causeOf GATA-3,regulating
R766 T883 T880 themeOf expression,regulating

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T923 11-17 Protein denotes GATA-3
T924 86-110 Protein denotes interleukin (IL)-4, IL-5
T925 58-68 Gene_expression denotes expression
T926 43-53 Regulation denotes regulating
T927 300-306 Protein denotes GATA-3
T928 289-296 Regulation denotes effects
T929 395-401 Protein denotes GATA-3
T930 402-412 Regulation denotes regulation
T931 340-346 Regulation denotes effect
T932 570-578 Protein denotes anti-CD3
T933 583-592 Protein denotes anti-CD28
T934 669-675 Protein denotes GATA-3
T935 739-756 Protein denotes nuclear factor-κB
T936 801-807 Protein denotes GATA-3
T937 833-856 Protein denotes glucocorticoid receptor
T938 644-651 Entity denotes nuclear
T939 652-665 Localization denotes translocation
T940 816-832 Positive_regulation denotes ligand-activated
T941 635-643 Negative_regulation denotes inhibits
T942 971-1003 Protein denotes mitogen-activated protein kinase
T943 1005-1009 Protein denotes MAPK
T944 1062-1070 Protein denotes p38 MAPK
T945 957-967 Gene_expression denotes expression
T946 957-967 Gene_expression denotes expression
T947 1049-1058 Negative_regulation denotes inhibitor
T948 1110-1123 Localization denotes translocation
T949 945-952 Positive_regulation denotes induces
T950 945-952 Positive_regulation denotes induces
T951 1081-1090 Positive_regulation denotes necessary
T952 1412-1418 Protein denotes GATA-3
T953 1473-1476 Protein denotes Th2
T954 1402-1408 Negative_regulation denotes effect
T955 1486-1496 Gene_expression denotes expression
T956 1464-1472 Negative_regulation denotes suppress
R752 T942 T945 themeOf mitogen-activated protein kinase,expression
R754 T943 T946 themeOf MAPK,expression
R755 T943 T948 themeOf MAPK,translocation
R756 T944 T947 themeOf p38 MAPK,inhibitor
R758 T945 T949 themeOf expression,induces
R759 T946 T950 themeOf expression,induces
R761 T948 T951 themeOf translocation,necessary
R764 T952 T954 themeOf GATA-3,effect
R765 T953 T955 themeOf Th2,expression
R767 T955 T956 themeOf expression,suppress
R739 T923 T926 causeOf GATA-3,regulating
R740 T924 T925 themeOf "interleukin (IL)-4, IL-5",expression
R742 T925 T926 themeOf expression,regulating
R743 T927 T928 themeOf GATA-3,effects
R744 T929 T930 themeOf GATA-3,regulation
R745 T930 T931 themeOf regulation,effect
R746 T934 T939 themeOf GATA-3,translocation
R747 T937 T940 themeOf glucocorticoid receptor,ligand-activated
R748 T938 T939 locationOf nuclear,translocation
R750 T939 T941 themeOf translocation,inhibits

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue
T96 43-53 Regulation denotes regulating
T97 43-53 Regulation denotes regulating
T98 43-53 Regulation denotes regulating
T99 58-68 Gene_expression denotes expression
T100 58-68 Gene_expression denotes expression
T101 58-68 Gene_expression denotes expression
T102 86-104 Protein denotes interleukin (IL)-4
T103 106-110 Protein denotes IL-5
T104 116-121 Protein denotes IL-13
T105 300-306 Protein denotes GATA-3
T106 340-346 Regulation denotes effect
T107 395-401 Protein denotes GATA-3
T108 402-412 Regulation denotes regulation
T109 635-643 Negative_regulation denotes inhibits
T110 644-651 Entity denotes nuclear
T111 652-665 Localization denotes translocation
T112 669-675 Protein denotes GATA-3
T113 781-792 Negative_regulation denotes competition
T114 781-792 Negative_regulation denotes competition
T115 801-807 Protein denotes GATA-3
T116 823-832 Positive_regulation denotes activated
T117 833-856 Protein denotes glucocorticoid receptor
T118 861-868 Entity denotes nuclear
T119 869-878 Localization denotes transport
T120 869-878 Localization denotes transport
T121 945-952 Positive_regulation denotes induces
T122 957-967 Gene_expression denotes expression
T123 971-1024 Protein denotes mitogen-activated protein kinase (MAPK) phosphatase-1
T124 1026-1031 Protein denotes MKP-1
T125 1081-1090 Positive_regulation denotes necessary
T126 1095-1101 Protein denotes GATA-3
T127 1102-1109 Entity denotes nuclear
T128 1110-1123 Localization denotes translocation
T129 1245-1253 Negative_regulation denotes inhibits
T130 1254-1260 Protein denotes GATA-3
T131 1261-1268 Entity denotes nuclear
T132 1269-1282 Localization denotes translocation
T133 1391-1408 Negative_regulation denotes inhibitory effect
T134 1412-1418 Protein denotes GATA-3
T95 11-17 Protein denotes GATA-3
R71 T99 T96 themeOf expression,regulating
R72 T100 T98 themeOf expression,regulating
R74 T102 T100 themeOf interleukin (IL)-4,expression
R774 T95 T98 causeOf GATA-3,regulating
R775 T95 T96 causeOf GATA-3,regulating
R73 T101 T97 themeOf expression,regulating
R75 T103 T99 themeOf IL-5,expression
R76 T104 T101 themeOf IL-13,expression
R77 T107 T108 themeOf GATA-3,regulation
R78 T108 T106 themeOf regulation,effect
R79 T110 T111 locationOf nuclear,translocation
R80 T111 T109 themeOf translocation,inhibits
R81 T112 T111 themeOf GATA-3,translocation
R82 T115 T120 themeOf GATA-3,transport
R83 T117 T119 themeOf glucocorticoid receptor,transport
R84 T117 T116 themeOf glucocorticoid receptor,activated
R85 T118 T120 locationOf nuclear,transport
R86 T118 T119 locationOf nuclear,transport
R87 T119 T113 themeOf transport,competition
R88 T120 T114 themeOf transport,competition
R89 T122 T121 themeOf expression,induces
R90 T123 T122 themeOf mitogen-activated protein kinase (MAPK) phosphatase-1,expression
R91 T124 T123 equivalentTo MKP-1,mitogen-activated protein kinase (MAPK) phosphatase-1
R92 T126 T128 themeOf GATA-3,translocation
R93 T127 T128 locationOf nuclear,translocation
R94 T128 T125 themeOf translocation,necessary
R95 T130 T132 themeOf GATA-3,translocation
R96 T131 T132 locationOf nuclear,translocation
R97 T132 T129 themeOf translocation,inhibits
R98 T134 T133 themeOf GATA-3,inhibitory effect
R776 T95 T97 causeOf GATA-3,regulating

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T431 11-17 P23771 denotes GATA-3
T432 106-110 P05113 denotes IL-5
T433 116-121 P35225 denotes IL-13
T434 300-306 P23771 denotes GATA-3
T435 395-401 P23771 denotes GATA-3
T436 575-578 P04234 denotes CD3
T437 575-578 P20963 denotes CD3
T438 575-578 P09693 denotes CD3
T439 575-578 P07766 denotes CD3
T440 588-592 P10747 denotes CD28
T441 669-675 P23771 denotes GATA-3
T442 801-807 P23771 denotes GATA-3
T443 833-856 P04150 denotes glucocorticoid receptor
T444 971-1003 P27361 denotes mitogen-activated protein kinase
T445 971-1003 P28482 denotes mitogen-activated protein kinase
T446 1026-1031 P28562 denotes MKP-1
T447 1062-1065 P53778 denotes p38
T448 1062-1065 Q16539 denotes p38
T449 1062-1065 Q15759 denotes p38
T450 1062-1065 O15264 denotes p38
T451 1095-1101 P23771 denotes GATA-3
T452 1254-1260 P23771 denotes GATA-3
T453 1412-1418 P23771 denotes GATA-3

test2

Id Subject Object Predicate Lexical cue
T52 11-17 Protein denotes GATA-3
T53 35-39 Regulation denotes role
T54 43-53 Regulation denotes regulating
T55 58-68 Gene_expression denotes expression
T56 86-104 Protein denotes interleukin (IL)-4
T57 106-110 Protein denotes IL-5
T58 116-121 Protein denotes IL-13
T59 289-296 Regulation denotes effects
T60 300-306 Protein denotes GATA-3
T61 395-401 Protein denotes GATA-3
T62 402-412 Regulation denotes regulation
T63 635-643 Negative_regulation denotes inhibits
T64 644-651 Entity denotes nuclear
T65 652-665 Localization denotes translocation
T66 669-675 Protein denotes GATA-3
T67 680-690 Gene_expression denotes expression
T68 724-735 Regulation denotes independent
T69 781-792 Negative_regulation denotes competition
T70 801-807 Protein denotes GATA-3
T71 823-832 Positive_regulation denotes activated
T72 833-856 Protein denotes glucocorticoid receptor
T73 945-952 Positive_regulation denotes induces
T74 957-967 Gene_expression denotes expression
T75 971-1024 Protein denotes mitogen-activated protein kinase (MAPK) phosphatase-1
T76 1026-1031 Protein denotes MKP-1
T77 1081-1090 Positive_regulation denotes necessary
T78 1095-1101 Protein denotes GATA-3
T79 1102-1109 Entity denotes nuclear
T80 1110-1123 Localization denotes translocation
T81 1245-1253 Negative_regulation denotes inhibits
T82 1254-1260 Protein denotes GATA-3
T83 1261-1268 Entity denotes nuclear
T84 1269-1282 Localization denotes translocation
T85 1391-1408 Negative_regulation denotes inhibitory effect
T86 1412-1418 Protein denotes GATA-3
R59 T72 T71 themeOf glucocorticoid receptor,activated
R60 T74 T73 themeOf expression,induces
R61 T74 T77 causeOf expression,necessary
R62 T75 T74 themeOf mitogen-activated protein kinase (MAPK) phosphatase-1,expression
R63 T76 T75 equivalentTo MKP-1,mitogen-activated protein kinase (MAPK) phosphatase-1
R64 T78 T80 themeOf GATA-3,translocation
R65 T79 T80 locationOf nuclear,translocation
R66 T80 T77 themeOf translocation,necessary
R67 T82 T84 themeOf GATA-3,translocation
R68 T83 T84 locationOf nuclear,translocation
R69 T84 T81 themeOf translocation,inhibits
R70 T86 T85 themeOf GATA-3,inhibitory effect
R42 T52 T54 causeOf GATA-3,regulating
R43 T52 T53 causeOf GATA-3,role
R44 T55 T54 themeOf expression,regulating
R45 T56 T55 themeOf interleukin (IL)-4,expression
R46 T57 T55 themeOf IL-5,expression
R47 T58 T55 themeOf IL-13,expression
R48 T60 T59 themeOf GATA-3,effects
R49 T61 T62 themeOf GATA-3,regulation
R50 T63 T68 themeOf inhibits,independent
R51 T64 T65 locationOf nuclear,translocation
R52 T65 T68 themeOf translocation,independent
R53 T65 T63 themeOf translocation,inhibits
R54 T66 T67 themeOf GATA-3,expression
R55 T67 T63 themeOf expression,inhibits
R56 T67 T68 themeOf expression,independent
R57 T70 T71 themeOf GATA-3,activated
R58 T70 T69 themeOf GATA-3,competition