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{"project":"events-check-again","denotations":[{"id":"T15926","span":{"begin":130,"end":147},"obj":"Negative_regulation"},{"id":"T15927","span":{"begin":130,"end":147},"obj":"Negative_regulation"},{"id":"T15928","span":{"begin":151,"end":157},"obj":"Protein"},{"id":"T15929","span":{"begin":158,"end":165},"obj":"Entity"},{"id":"T15930","span":{"begin":166,"end":179},"obj":"Localization"},{"id":"T15931","span":{"begin":196,"end":203},"obj":"Binding"},{"id":"T15932","span":{"begin":288,"end":297},"obj":"Positive_regulation"},{"id":"T15933","span":{"begin":298,"end":307},"obj":"Gene_expression"},{"id":"T15934","span":{"begin":311,"end":316},"obj":"Protein"},{"id":"T15935","span":{"begin":348,"end":358},"obj":"Negative_regulation"},{"id":"T15936","span":{"begin":363,"end":378},"obj":"Phosphorylation"},{"id":"T15937","span":{"begin":382,"end":388},"obj":"Protein"},{"id":"T15938","span":{"begin":397,"end":406},"obj":"Positive_regulation"},{"id":"T15939","span":{"begin":411,"end":418},"obj":"Entity"},{"id":"T15940","span":{"begin":419,"end":432},"obj":"Localization"},{"id":"T15941","span":{"begin":436,"end":442},"obj":"Protein"}],"relations":[{"id":"R13683","pred":"themeOf","subj":"T15928","obj":"T15930"},{"id":"R13684","pred":"themeOf","subj":"T15928","obj":"T15931"},{"id":"R13685","pred":"locationOf","subj":"T15929","obj":"T15930"},{"id":"R13686","pred":"themeOf","subj":"T15930","obj":"T15927"},{"id":"R13687","pred":"themeOf","subj":"T15930","obj":"T15926"},{"id":"R13688","pred":"causeOf","subj":"T15931","obj":"T15927"},{"id":"R13689","pred":"causeOf","subj":"T15932","obj":"T15926"},{"id":"R13690","pred":"causeOf","subj":"T15932","obj":"T15935"},{"id":"R13691","pred":"themeOf","subj":"T15933","obj":"T15932"},{"id":"R13692","pred":"themeOf","subj":"T15934","obj":"T15933"},{"id":"R13693","pred":"themeOf","subj":"T15936","obj":"T15935"},{"id":"R13694","pred":"themeOf","subj":"T15937","obj":"T15936"},{"id":"R13695","pred":"locationOf","subj":"T15939","obj":"T15940"},{"id":"R13696","pred":"themeOf","subj":"T15940","obj":"T15938"},{"id":"R13697","pred":"themeOf","subj":"T15941","obj":"T15940"}],"text":"In summary, our data provide evidence for a novel action of corticosteroids: suppression of allergic inflammation through a rapid inhibitory effect on GATA-3 nuclear translocation by preferential binding to the shared nuclear import protein importin-α and by a second mechanism involving increased synthesis of MKP-1, which inhibits p38 MAPK, thus preventing the phosphorylation of GATA-3 that is necessary for nuclear translocation of GATA-3."}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T15764","span":{"begin":241,"end":251},"obj":"Protein"},{"id":"T15765","span":{"begin":311,"end":316},"obj":"Protein"},{"id":"T15766","span":{"begin":333,"end":341},"obj":"Protein"},{"id":"T15767","span":{"begin":382,"end":388},"obj":"Protein"},{"id":"T15768","span":{"begin":436,"end":442},"obj":"Protein"},{"id":"T15769","span":{"begin":158,"end":165},"obj":"Entity"},{"id":"T15770","span":{"begin":196,"end":203},"obj":"Binding"},{"id":"T15771","span":{"begin":298,"end":307},"obj":"Gene_expression"},{"id":"T15772","span":{"begin":324,"end":332},"obj":"Negative_regulation"},{"id":"T15773","span":{"begin":363,"end":378},"obj":"Phosphorylation"},{"id":"T15774","span":{"begin":411,"end":418},"obj":"Entity"},{"id":"T15775","span":{"begin":419,"end":432},"obj":"Localization"},{"id":"T15776","span":{"begin":288,"end":297},"obj":"Positive_regulation"},{"id":"T15777","span":{"begin":348,"end":358},"obj":"Negative_regulation"},{"id":"T15778","span":{"begin":397,"end":406},"obj":"Positive_regulation"}],"relations":[{"id":"R13530","pred":"themeOf","subj":"T15764","obj":"T15770"},{"id":"R13531","pred":"themeOf","subj":"T15765","obj":"T15771"},{"id":"R13533","pred":"themeOf","subj":"T15766","obj":"T15772"},{"id":"R13534","pred":"themeOf","subj":"T15767","obj":"T15773"},{"id":"R13535","pred":"causeOf","subj":"T15767","obj":"T15778"},{"id":"R13536","pred":"themeOf","subj":"T15768","obj":"T15775"},{"id":"R13537","pred":"themeOf","subj":"T15771","obj":"T15776"},{"id":"R13538","pred":"themeOf","subj":"T15773","obj":"T15777"},{"id":"R13539","pred":"locationOf","subj":"T15774","obj":"T15775"},{"id":"R13540","pred":"themeOf","subj":"T15775","obj":"T15778"}],"text":"In summary, our data provide evidence for a novel action of corticosteroids: suppression of allergic inflammation through a rapid inhibitory effect on GATA-3 nuclear translocation by preferential binding to the shared nuclear import protein importin-α and by a second mechanism involving increased synthesis of MKP-1, which inhibits p38 MAPK, thus preventing the phosphorylation of GATA-3 that is necessary for nuclear translocation of GATA-3."}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T13303","span":{"begin":130,"end":147},"obj":"Negative_regulation"},{"id":"T13304","span":{"begin":130,"end":147},"obj":"Negative_regulation"},{"id":"T13305","span":{"begin":151,"end":157},"obj":"Protein"},{"id":"T13306","span":{"begin":158,"end":165},"obj":"Entity"},{"id":"T13307","span":{"begin":166,"end":179},"obj":"Localization"},{"id":"T13308","span":{"begin":196,"end":203},"obj":"Binding"},{"id":"T13309","span":{"begin":288,"end":297},"obj":"Positive_regulation"},{"id":"T13310","span":{"begin":298,"end":307},"obj":"Gene_expression"},{"id":"T13311","span":{"begin":311,"end":316},"obj":"Protein"},{"id":"T13312","span":{"begin":348,"end":358},"obj":"Negative_regulation"},{"id":"T13313","span":{"begin":363,"end":378},"obj":"Phosphorylation"},{"id":"T13314","span":{"begin":382,"end":388},"obj":"Protein"},{"id":"T13315","span":{"begin":397,"end":406},"obj":"Positive_regulation"},{"id":"T13316","span":{"begin":411,"end":418},"obj":"Entity"},{"id":"T13317","span":{"begin":419,"end":432},"obj":"Localization"},{"id":"T13318","span":{"begin":436,"end":442},"obj":"Protein"}],"relations":[{"id":"R11401","pred":"themeOf","subj":"T13305","obj":"T13307"},{"id":"R11402","pred":"themeOf","subj":"T13305","obj":"T13308"},{"id":"R11403","pred":"locationOf","subj":"T13306","obj":"T13307"},{"id":"R11404","pred":"themeOf","subj":"T13307","obj":"T13304"},{"id":"R11405","pred":"themeOf","subj":"T13307","obj":"T13303"},{"id":"R11406","pred":"causeOf","subj":"T13308","obj":"T13304"},{"id":"R11407","pred":"causeOf","subj":"T13309","obj":"T13303"},{"id":"R11408","pred":"causeOf","subj":"T13309","obj":"T13312"},{"id":"R11409","pred":"themeOf","subj":"T13310","obj":"T13309"},{"id":"R11410","pred":"themeOf","subj":"T13311","obj":"T13310"},{"id":"R11411","pred":"themeOf","subj":"T13313","obj":"T13312"},{"id":"R11412","pred":"themeOf","subj":"T13314","obj":"T13313"},{"id":"R11413","pred":"locationOf","subj":"T13316","obj":"T13317"},{"id":"R11414","pred":"themeOf","subj":"T13317","obj":"T13315"},{"id":"R11415","pred":"themeOf","subj":"T13318","obj":"T13317"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"In summary, our data provide evidence for a novel action of corticosteroids: suppression of allergic inflammation through a rapid inhibitory effect on GATA-3 nuclear translocation by preferential binding to the shared nuclear import protein importin-α and by a second mechanism involving increased synthesis of MKP-1, which inhibits p38 MAPK, thus preventing the phosphorylation of GATA-3 that is necessary for nuclear translocation of GATA-3."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T14300","span":{"begin":151,"end":157},"obj":"P23771"},{"id":"T14301","span":{"begin":311,"end":316},"obj":"P28562"},{"id":"T14302","span":{"begin":333,"end":336},"obj":"Q16539"},{"id":"T14303","span":{"begin":333,"end":336},"obj":"Q15759"},{"id":"T14304","span":{"begin":333,"end":336},"obj":"P53778"},{"id":"T14305","span":{"begin":333,"end":336},"obj":"O15264"},{"id":"T14306","span":{"begin":382,"end":388},"obj":"P23771"},{"id":"T14307","span":{"begin":436,"end":442},"obj":"P23771"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"In summary, our data provide evidence for a novel action of corticosteroids: suppression of allergic inflammation through a rapid inhibitory effect on GATA-3 nuclear translocation by preferential binding to the shared nuclear import protein importin-α and by a second mechanism involving increased synthesis of MKP-1, which inhibits p38 MAPK, thus preventing the phosphorylation of GATA-3 that is necessary for nuclear translocation of GATA-3."}

{"project":"test2","denotations":[{"id":"T13138","span":{"begin":141,"end":147},"obj":"Regulation"},{"id":"T13139","span":{"begin":151,"end":157},"obj":"Protein"},{"id":"T13140","span":{"begin":158,"end":165},"obj":"Entity"},{"id":"T13141","span":{"begin":166,"end":179},"obj":"Localization"},{"id":"T13142","span":{"begin":196,"end":203},"obj":"Binding"},{"id":"T13143","span":{"begin":218,"end":225},"obj":"Entity"},{"id":"T13144","span":{"begin":226,"end":232},"obj":"Localization"},{"id":"T13145","span":{"begin":288,"end":297},"obj":"Positive_regulation"},{"id":"T13146","span":{"begin":298,"end":307},"obj":"Gene_expression"},{"id":"T13147","span":{"begin":311,"end":316},"obj":"Protein"},{"id":"T13148","span":{"begin":348,"end":358},"obj":"Negative_regulation"},{"id":"T13149","span":{"begin":363,"end":378},"obj":"Phosphorylation"},{"id":"T13150","span":{"begin":382,"end":388},"obj":"Protein"},{"id":"T13151","span":{"begin":397,"end":406},"obj":"Positive_regulation"},{"id":"T13152","span":{"begin":411,"end":418},"obj":"Entity"},{"id":"T13153","span":{"begin":419,"end":432},"obj":"Localization"},{"id":"T13154","span":{"begin":436,"end":442},"obj":"Protein"}],"relations":[{"id":"R11270","pred":"themeOf","subj":"T13139","obj":"T13144"},{"id":"R11271","pred":"themeOf","subj":"T13139","obj":"T13141"},{"id":"R11272","pred":"locationOf","subj":"T13140","obj":"T13141"},{"id":"R11273","pred":"themeOf","subj":"T13141","obj":"T13138"},{"id":"R11274","pred":"locationOf","subj":"T13143","obj":"T13144"},{"id":"R11275","pred":"themeOf","subj":"T13146","obj":"T13145"},{"id":"R11276","pred":"themeOf","subj":"T13147","obj":"T13146"},{"id":"R11277","pred":"causeOf","subj":"T13149","obj":"T13151"},{"id":"R11278","pred":"themeOf","subj":"T13149","obj":"T13148"},{"id":"R11279","pred":"themeOf","subj":"T13150","obj":"T13149"},{"id":"R11280","pred":"locationOf","subj":"T13152","obj":"T13153"},{"id":"R11281","pred":"themeOf","subj":"T13153","obj":"T13151"},{"id":"R11282","pred":"themeOf","subj":"T13154","obj":"T13153"}],"text":"In summary, our data provide evidence for a novel action of corticosteroids: suppression of allergic inflammation through a rapid inhibitory effect on GATA-3 nuclear translocation by preferential binding to the shared nuclear import protein importin-α and by a second mechanism involving increased synthesis of MKP-1, which inhibits p38 MAPK, thus preventing the phosphorylation of GATA-3 that is necessary for nuclear translocation of GATA-3."}