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PMC:2674207 / 44453-44896 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T14078 0-2 IN denotes In
T14079 3-10 NN denotes summary
T14080 10-11 -COMMA- denotes ,
T14081 12-15 PRP-DOLLAR- denotes our
T14082 16-20 NN denotes data
T14083 21-28 VB denotes provide
T14084 29-37 NN denotes evidence
T14085 38-41 IN denotes for
T14086 42-43 DT denotes a
T14087 44-49 JJ denotes novel
T14088 50-56 NN denotes action
T14089 57-59 IN denotes of
T14090 60-75 NN denotes corticosteroids
T14091 75-76 -COLON- denotes :
T14092 77-88 NN denotes suppression
T14093 89-91 IN denotes of
T14094 92-100 JJ denotes allergic
T14095 101-113 NN denotes inflammation
T14096 114-121 IN denotes through
T14097 122-123 DT denotes a
T14098 124-129 JJ denotes rapid
T14099 130-140 JJ denotes inhibitory
T14100 141-147 NN denotes effect
T14101 148-150 IN denotes on
T14102 151-157 NN denotes GATA-3
T14103 158-165 JJ denotes nuclear
T14104 166-179 NN denotes translocation
T14105 180-182 IN denotes by
T14106 183-195 JJ denotes preferential
T14107 196-203 NN denotes binding
T14108 204-206 TO denotes to
T14109 207-210 DT denotes the
T14110 211-217 JJ denotes shared
T14111 218-225 JJ denotes nuclear
T14112 226-232 NN denotes import
T14113 233-240 NN denotes protein
T14114 241-251 NN denotes importin-α
T14115 252-255 CC denotes and
T14116 256-258 IN denotes by
T14117 259-260 DT denotes a
T14118 261-267 JJ denotes second
T14119 268-277 NN denotes mechanism
T14120 278-287 VB denotes involving
T14121 288-297 VB denotes increased
T14122 298-307 NN denotes synthesis
T14123 308-310 IN denotes of
T14124 311-316 NN denotes MKP-1
T14125 316-317 -COMMA- denotes ,
T14126 318-323 WDT denotes which
T14127 324-332 VB denotes inhibits
T14128 333-336 NN denotes p38
T14129 337-341 NN denotes MAPK
T14130 341-342 -COMMA- denotes ,
T14131 343-347 RB denotes thus
T14132 348-358 VB denotes preventing
T14133 359-362 DT denotes the
T14134 363-378 NN denotes phosphorylation
T14135 379-381 IN denotes of
T14136 382-388 NN denotes GATA-3
T14137 389-393 WDT denotes that
T14138 394-396 VB denotes is
T14139 397-406 JJ denotes necessary
T14140 407-410 IN denotes for
T14141 411-418 JJ denotes nuclear
T14142 419-432 NN denotes translocation
T14143 433-435 IN denotes of
T14144 436-442 NN denotes GATA-3
R12170 T14079 T14078 arg2Of summary,In
R12171 T14082 T14081 arg1Of data,our
R12172 T14082 T14083 arg1Of data,provide
R12173 T14083 T14078 arg1Of provide,In
R12174 T14083 T14080 arg1Of provide,","
R12175 T14083 T14096 arg1Of provide,through
R12176 T14083 T14116 arg1Of provide,by
R12177 T14084 T14083 arg2Of evidence,provide
R12178 T14084 T14085 arg1Of evidence,for
R12179 T14088 T14089 arg1Of action,of
R12180 T14090 T14089 arg2Of corticosteroids,of
R12181 T14090 T14091 arg1Of corticosteroids,:
R12182 T14092 T14085 arg2Of suppression,for
R12183 T14092 T14086 arg1Of suppression,a
R12184 T14092 T14087 arg1Of suppression,novel
R12185 T14092 T14088 arg1Of suppression,action
R12186 T14092 T14093 arg1Of suppression,of
R12187 T14095 T14093 arg2Of inflammation,of
R12188 T14095 T14094 arg1Of inflammation,allergic
R12189 T14096 T14115 arg1Of through,and
R12190 T14100 T14096 arg2Of effect,through
R12191 T14100 T14097 arg1Of effect,a
R12192 T14100 T14098 arg1Of effect,rapid
R12193 T14100 T14099 arg1Of effect,inhibitory
R12194 T14100 T14101 arg1Of effect,on
R12195 T14100 T14105 arg1Of effect,by
R12196 T14104 T14101 arg2Of translocation,on
R12197 T14104 T14102 arg1Of translocation,GATA-3
R12198 T14104 T14103 arg1Of translocation,nuclear
R12199 T14107 T14105 arg2Of binding,by
R12200 T14107 T14106 arg1Of binding,preferential
R12201 T14107 T14108 arg1Of binding,to
R12202 T14114 T14108 arg2Of importin-α,to
R12203 T14114 T14109 arg1Of importin-α,the
R12204 T14114 T14110 arg1Of importin-α,shared
R12205 T14114 T14111 arg1Of importin-α,nuclear
R12206 T14114 T14112 arg1Of importin-α,import
R12207 T14114 T14113 arg1Of importin-α,protein
R12208 T14116 T14115 arg2Of by,and
R12209 T14119 T14116 arg2Of mechanism,by
R12210 T14119 T14117 arg1Of mechanism,a
R12211 T14119 T14118 arg1Of mechanism,second
R12212 T14119 T14120 arg1Of mechanism,involving
R12213 T14122 T14120 arg2Of synthesis,involving
R12214 T14122 T14121 arg2Of synthesis,increased
R12215 T14122 T14123 arg1Of synthesis,of
R12216 T14122 T14125 arg1Of synthesis,","
R12217 T14122 T14126 arg1Of synthesis,which
R12218 T14122 T14127 arg1Of synthesis,inhibits
R12219 T14124 T14123 arg2Of MKP-1,of
R12220 T14127 T14130 arg1Of inhibits,","
R12221 T14127 T14132 modOf inhibits,preventing
R12222 T14129 T14127 arg2Of MAPK,inhibits
R12223 T14129 T14128 arg1Of MAPK,p38
R12224 T14132 T14131 arg1Of preventing,thus
R12225 T14134 T14132 arg2Of phosphorylation,preventing
R12226 T14134 T14133 arg1Of phosphorylation,the
R12227 T14134 T14135 arg1Of phosphorylation,of
R12228 T14134 T14137 arg1Of phosphorylation,that
R12229 T14134 T14138 arg1Of phosphorylation,is
R12230 T14134 T14139 arg1Of phosphorylation,necessary
R12231 T14136 T14135 arg2Of GATA-3,of
R12232 T14139 T14138 arg2Of necessary,is
R12233 T14139 T14140 arg1Of necessary,for
R12234 T14142 T14140 arg2Of translocation,for
R12235 T14142 T14141 arg1Of translocation,nuclear
R12236 T14142 T14143 arg1Of translocation,of
R12237 T14144 T14143 arg2Of GATA-3,of

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T15063 0-2 IN denotes In
T15064 3-10 NN denotes summary
T15065 10-11 , denotes ,
T15066 12-15 PRP$ denotes our
T15067 16-20 NNS denotes data
T15068 21-28 VBP denotes provide
T15069 29-37 NN denotes evidence
T15070 38-41 IN denotes for
T15071 42-43 DT denotes a
T15072 44-49 NN denotes novel
T15073 50-56 NN denotes action
T15074 57-59 IN denotes of
T15075 60-75 NNS denotes corticosteroids
T15076 75-76 : denotes :
T15077 77-88 NN denotes suppression
T15078 89-91 IN denotes of
T15079 92-100 JJ denotes allergic
T15080 101-113 NN denotes inflammation
T15081 114-121 IN denotes through
T15082 122-123 DT denotes a
T15083 124-129 JJ denotes rapid
T15084 130-140 JJ denotes inhibitory
T15085 141-147 NN denotes effect
T15086 148-150 IN denotes on
T15087 151-157 JJ denotes GATA-3
T15088 158-165 JJ denotes nuclear
T15089 166-179 NN denotes translocation
T15090 180-182 IN denotes by
T15091 183-195 JJ denotes preferential
T15092 196-203 JJ denotes binding
T15093 204-206 TO denotes to
T15094 207-210 DT denotes the
T15095 211-217 VBN denotes shared
T15096 218-225 JJ denotes nuclear
T15097 226-232 NN denotes import
T15098 233-240 NN denotes protein
T15099 241-251 NN denotes importin-α
T15100 252-255 CC denotes and
T15101 256-258 IN denotes by
T15102 259-260 DT denotes a
T15103 261-267 JJ denotes second
T15104 268-277 NN denotes mechanism
T15105 278-287 VBG denotes involving
T15106 288-297 VBN denotes increased
T15107 298-307 NN denotes synthesis
T15108 308-310 IN denotes of
T15109 311-316 NNP denotes MKP-1
T15110 316-317 , denotes ,
T15111 318-323 WDT denotes which
T15112 324-332 VBZ denotes inhibits
T15113 333-336 CD denotes p38
T15114 337-341 NNP denotes MAPK
T15115 341-342 , denotes ,
T15116 343-347 RB denotes thus
T15117 348-358 VBG denotes preventing
T15118 359-362 DT denotes the
T15119 363-378 NN denotes phosphorylation
T15120 379-381 IN denotes of
T15121 382-388 NN denotes GATA-3
T15122 389-393 WDT denotes that
T15123 394-396 VBZ denotes is
T15124 397-406 JJ denotes necessary
T15125 407-410 IN denotes for
T15126 411-418 JJ denotes nuclear
T15127 419-432 NN denotes translocation
T15128 433-435 IN denotes of
T15129 436-442 NN denotes GATA-3
T15130 442-443 . denotes .
R13075 T15063 T15068 prep In,provide
R13076 T15064 T15063 pobj summary,In
R13077 T15065 T15068 punct ",",provide
R13078 T15066 T15067 poss our,data
R13079 T15067 T15068 nsubj data,provide
R13080 T15068 T15068 ROOT provide,provide
R13081 T15069 T15068 dobj evidence,provide
R13082 T15070 T15069 prep for,evidence
R13083 T15071 T15073 det a,action
R13084 T15072 T15073 compound novel,action
R13085 T15073 T15070 pobj action,for
R13086 T15074 T15073 prep of,action
R13087 T15075 T15074 pobj corticosteroids,of
R13088 T15076 T15069 punct :,evidence
R13089 T15077 T15069 conj suppression,evidence
R13090 T15078 T15077 prep of,suppression
R13091 T15079 T15080 amod allergic,inflammation
R13092 T15080 T15078 pobj inflammation,of
R13093 T15081 T15068 prep through,provide
R13094 T15082 T15085 det a,effect
R13095 T15083 T15085 amod rapid,effect
R13096 T15084 T15085 amod inhibitory,effect
R13097 T15085 T15081 pobj effect,through
R13098 T15086 T15085 prep on,effect
R13099 T15087 T15089 amod GATA-3,translocation
R13100 T15088 T15089 amod nuclear,translocation
R13101 T15089 T15086 pobj translocation,on
R13102 T15090 T15085 prep by,effect
R13103 T15091 T15092 amod preferential,binding
R13104 T15092 T15085 amod binding,effect
R13105 T15093 T15092 prep to,binding
R13106 T15094 T15098 det the,protein
R13107 T15095 T15098 amod shared,protein
R13108 T15096 T15097 amod nuclear,import
R13109 T15097 T15098 compound import,protein
R13110 T15098 T15099 compound protein,importin-α
R13111 T15099 T15093 pobj importin-α,to
R13112 T15100 T15081 cc and,through
R13113 T15101 T15081 conj by,through
R13114 T15102 T15104 det a,mechanism
R13115 T15103 T15104 amod second,mechanism
R13116 T15104 T15101 pobj mechanism,by
R13117 T15105 T15104 acl involving,mechanism
R13118 T15106 T15107 amod increased,synthesis
R13119 T15107 T15068 dobj synthesis,provide
R13120 T15108 T15107 prep of,synthesis
R13121 T15109 T15108 pobj MKP-1,of
R13122 T15110 T15109 punct ",",MKP-1
R13123 T15111 T15112 nsubj which,inhibits
R13124 T15112 T15109 relcl inhibits,MKP-1
R13125 T15113 T15114 nummod p38,MAPK
R13126 T15114 T15112 dobj MAPK,inhibits
R13127 T15115 T15068 punct ",",provide
R13128 T15116 T15117 advmod thus,preventing
R13129 T15117 T15068 advcl preventing,provide
R13130 T15118 T15119 det the,phosphorylation
R13131 T15119 T15117 dobj phosphorylation,preventing
R13132 T15120 T15119 prep of,phosphorylation
R13133 T15121 T15120 pobj GATA-3,of
R13134 T15122 T15123 nsubj that,is
R13135 T15123 T15121 relcl is,GATA-3
R13136 T15124 T15123 acomp necessary,is
R13137 T15125 T15124 prep for,necessary
R13138 T15126 T15127 amod nuclear,translocation
R13139 T15127 T15125 pobj translocation,for
R13140 T15128 T15127 prep of,translocation
R13141 T15129 T15128 pobj GATA-3,of
R13142 T15130 T15068 punct .,provide

GO-BP

Id Subject Object Predicate Lexical cue
T15249 218-232 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15265 337-341 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15269 363-378 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T15275 298-307 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T15277 101-113 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15279 226-240 http://purl.obolibrary.org/obo/GO_0017038 denotes import protein

GO-MF

Id Subject Object Predicate Lexical cue
T15302 337-341 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15311 196-203 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

sentences

Id Subject Object Predicate Lexical cue
T13347 0-443 Sentence denotes In summary, our data provide evidence for a novel action of corticosteroids: suppression of allergic inflammation through a rapid inhibitory effect on GATA-3 nuclear translocation by preferential binding to the shared nuclear import protein importin-α and by a second mechanism involving increased synthesis of MKP-1, which inhibits p38 MAPK, thus preventing the phosphorylation of GATA-3 that is necessary for nuclear translocation of GATA-3.
T286 0-443 Sentence denotes In summary, our data provide evidence for a novel action of corticosteroids: suppression of allergic inflammation through a rapid inhibitory effect on GATA-3 nuclear translocation by preferential binding to the shared nuclear import protein importin-α and by a second mechanism involving increased synthesis of MKP-1, which inhibits p38 MAPK, thus preventing the phosphorylation of GATA-3 that is necessary for nuclear translocation of GATA-3.

events-check-again

Id Subject Object Predicate Lexical cue
T15926 130-147 Negative_regulation denotes inhibitory effect
T15927 130-147 Negative_regulation denotes inhibitory effect
T15928 151-157 Protein denotes GATA-3
T15929 158-165 Entity denotes nuclear
T15930 166-179 Localization denotes translocation
T15931 196-203 Binding denotes binding
T15932 288-297 Positive_regulation denotes increased
T15933 298-307 Gene_expression denotes synthesis
T15934 311-316 Protein denotes MKP-1
T15935 348-358 Negative_regulation denotes preventing
T15936 363-378 Phosphorylation denotes phosphorylation
T15937 382-388 Protein denotes GATA-3
T15938 397-406 Positive_regulation denotes necessary
T15939 411-418 Entity denotes nuclear
T15940 419-432 Localization denotes translocation
T15941 436-442 Protein denotes GATA-3
R13683 T15928 T15930 themeOf GATA-3,translocation
R13684 T15928 T15931 themeOf GATA-3,binding
R13685 T15929 T15930 locationOf nuclear,translocation
R13686 T15930 T15927 themeOf translocation,inhibitory effect
R13687 T15930 T15926 themeOf translocation,inhibitory effect
R13688 T15931 T15927 causeOf binding,inhibitory effect
R13689 T15932 T15926 causeOf increased,inhibitory effect
R13690 T15932 T15935 causeOf increased,preventing
R13691 T15933 T15932 themeOf synthesis,increased
R13692 T15934 T15933 themeOf MKP-1,synthesis
R13693 T15936 T15935 themeOf phosphorylation,preventing
R13694 T15937 T15936 themeOf GATA-3,phosphorylation
R13695 T15939 T15940 locationOf nuclear,translocation
R13696 T15940 T15938 themeOf translocation,necessary
R13697 T15941 T15940 themeOf GATA-3,translocation

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T15764 241-251 Protein denotes importin-α
T15765 311-316 Protein denotes MKP-1
T15766 333-341 Protein denotes p38 MAPK
T15767 382-388 Protein denotes GATA-3
T15768 436-442 Protein denotes GATA-3
T15769 158-165 Entity denotes nuclear
T15770 196-203 Binding denotes binding
T15771 298-307 Gene_expression denotes synthesis
T15772 324-332 Negative_regulation denotes inhibits
T15773 363-378 Phosphorylation denotes phosphorylation
T15774 411-418 Entity denotes nuclear
T15775 419-432 Localization denotes translocation
T15776 288-297 Positive_regulation denotes increased
T15777 348-358 Negative_regulation denotes preventing
T15778 397-406 Positive_regulation denotes necessary
R13530 T15764 T15770 themeOf importin-α,binding
R13531 T15765 T15771 themeOf MKP-1,synthesis
R13533 T15766 T15772 themeOf p38 MAPK,inhibits
R13534 T15767 T15773 themeOf GATA-3,phosphorylation
R13535 T15767 T15778 causeOf GATA-3,necessary
R13536 T15768 T15775 themeOf GATA-3,translocation
R13537 T15771 T15776 themeOf synthesis,increased
R13538 T15773 T15777 themeOf phosphorylation,preventing
R13539 T15774 T15775 locationOf nuclear,translocation
R13540 T15775 T15778 themeOf translocation,necessary

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue
T13303 130-147 Negative_regulation denotes inhibitory effect
T13304 130-147 Negative_regulation denotes inhibitory effect
T13305 151-157 Protein denotes GATA-3
T13306 158-165 Entity denotes nuclear
T13307 166-179 Localization denotes translocation
T13308 196-203 Binding denotes binding
T13309 288-297 Positive_regulation denotes increased
T13310 298-307 Gene_expression denotes synthesis
T13311 311-316 Protein denotes MKP-1
T13312 348-358 Negative_regulation denotes preventing
T13313 363-378 Phosphorylation denotes phosphorylation
T13314 382-388 Protein denotes GATA-3
T13315 397-406 Positive_regulation denotes necessary
T13316 411-418 Entity denotes nuclear
T13317 419-432 Localization denotes translocation
T13318 436-442 Protein denotes GATA-3
R11401 T13305 T13307 themeOf GATA-3,translocation
R11402 T13305 T13308 themeOf GATA-3,binding
R11403 T13306 T13307 locationOf nuclear,translocation
R11404 T13307 T13304 themeOf translocation,inhibitory effect
R11405 T13307 T13303 themeOf translocation,inhibitory effect
R11406 T13308 T13304 causeOf binding,inhibitory effect
R11407 T13309 T13303 causeOf increased,inhibitory effect
R11408 T13309 T13312 causeOf increased,preventing
R11409 T13310 T13309 themeOf synthesis,increased
R11410 T13311 T13310 themeOf MKP-1,synthesis
R11411 T13313 T13312 themeOf phosphorylation,preventing
R11412 T13314 T13313 themeOf GATA-3,phosphorylation
R11413 T13316 T13317 locationOf nuclear,translocation
R11414 T13317 T13315 themeOf translocation,necessary
R11415 T13318 T13317 themeOf GATA-3,translocation

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T14300 151-157 P23771 denotes GATA-3
T14301 311-316 P28562 denotes MKP-1
T14302 333-336 Q16539 denotes p38
T14303 333-336 Q15759 denotes p38
T14304 333-336 P53778 denotes p38
T14305 333-336 O15264 denotes p38
T14306 382-388 P23771 denotes GATA-3
T14307 436-442 P23771 denotes GATA-3

test2

Id Subject Object Predicate Lexical cue
T13138 141-147 Regulation denotes effect
T13139 151-157 Protein denotes GATA-3
T13140 158-165 Entity denotes nuclear
T13141 166-179 Localization denotes translocation
T13142 196-203 Binding denotes binding
T13143 218-225 Entity denotes nuclear
T13144 226-232 Localization denotes import
T13145 288-297 Positive_regulation denotes increased
T13146 298-307 Gene_expression denotes synthesis
T13147 311-316 Protein denotes MKP-1
T13148 348-358 Negative_regulation denotes preventing
T13149 363-378 Phosphorylation denotes phosphorylation
T13150 382-388 Protein denotes GATA-3
T13151 397-406 Positive_regulation denotes necessary
T13152 411-418 Entity denotes nuclear
T13153 419-432 Localization denotes translocation
T13154 436-442 Protein denotes GATA-3
R11270 T13139 T13144 themeOf GATA-3,import
R11271 T13139 T13141 themeOf GATA-3,translocation
R11272 T13140 T13141 locationOf nuclear,translocation
R11273 T13141 T13138 themeOf translocation,effect
R11274 T13143 T13144 locationOf nuclear,import
R11275 T13146 T13145 themeOf synthesis,increased
R11276 T13147 T13146 themeOf MKP-1,synthesis
R11277 T13149 T13151 causeOf phosphorylation,necessary
R11278 T13149 T13148 themeOf phosphorylation,preventing
R11279 T13150 T13149 themeOf GATA-3,phosphorylation
R11280 T13152 T13153 locationOf nuclear,translocation
R11281 T13153 T13151 themeOf translocation,necessary
R11282 T13154 T13153 themeOf GATA-3,translocation