PMC:2674207 / 3457-4413 JSONTXT

{"project":"sentences","denotations":[{"id":"T28","span":{"begin":0,"end":24},"obj":"Sentence"},{"id":"T29","span":{"begin":25,"end":169},"obj":"Sentence"},{"id":"T30","span":{"begin":170,"end":371},"obj":"Sentence"},{"id":"T31","span":{"begin":372,"end":463},"obj":"Sentence"},{"id":"T32","span":{"begin":464,"end":586},"obj":"Sentence"},{"id":"T33","span":{"begin":587,"end":731},"obj":"Sentence"},{"id":"T34","span":{"begin":732,"end":956},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Why Was This Study Done?\nScientists know that corticosteroids reduce allergic inflammation by binding to proteins in immune system cells called glucocorticoid receptors. After binding to a corticosteroid, these receptors move into the nucleus of the cell (the part of the cell that contains its genes), where they suppress the expression of certain proinflammatory genes. However, it is still not known how corticosteroids inhibit the expression of Th2 cytokines. A key regulator of the expression of these cytokines and of allergic inflammation is a transcription factor called GATA-3. Transcription factors are proteins that control the expression of other proteins by binding to specific sequences in the genes that encode them. In this study, the researchers try to discover more about how corticosteroids reduce allergic inflammation by investigating the effects of the corticosteroid fluticasone on the regulation of GATA-3 activity in T lymphocytes."}