| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T28 |
0-24 |
Sentence |
denotes |
Why Was This Study Done? |
| T29 |
25-169 |
Sentence |
denotes |
Scientists know that corticosteroids reduce allergic inflammation by binding to proteins in immune system cells called glucocorticoid receptors. |
| T30 |
170-371 |
Sentence |
denotes |
After binding to a corticosteroid, these receptors move into the nucleus of the cell (the part of the cell that contains its genes), where they suppress the expression of certain proinflammatory genes. |
| T31 |
372-463 |
Sentence |
denotes |
However, it is still not known how corticosteroids inhibit the expression of Th2 cytokines. |
| T32 |
464-586 |
Sentence |
denotes |
A key regulator of the expression of these cytokines and of allergic inflammation is a transcription factor called GATA-3. |
| T33 |
587-731 |
Sentence |
denotes |
Transcription factors are proteins that control the expression of other proteins by binding to specific sequences in the genes that encode them. |
| T34 |
732-956 |
Sentence |
denotes |
In this study, the researchers try to discover more about how corticosteroids reduce allergic inflammation by investigating the effects of the corticosteroid fluticasone on the regulation of GATA-3 activity in T lymphocytes. |
