PMC:2669177 / 19337-20007 JSONTXT

{"project":"2_test","denotations":[{"id":"19390689-14507899-97510230","span":{"begin":291,"end":293},"obj":"14507899"},{"id":"19390689-14507899-97510230","span":{"begin":291,"end":293},"obj":"14507899"},{"id":"19390689-14507899-97876417","span":{"begin":291,"end":293},"obj":"14507899"},{"id":"19390689-14507899-97876417","span":{"begin":291,"end":293},"obj":"14507899"}],"text":"Although WT eyes can completely recover from P5 subretinal injections, we observed that ERG amplitudes from saline- and naked DNA-injected eyes in the rds+/− tended to be lower than in uninjected eyes (data not shown). These data, in combination with our earlier work on adult rds +/− mice [41], suggest that the rds +/− eye is more fragile than the normal eye and that subretinal injections per se in the mutant may cause adverse effects on visual function which would need to be overcome by any treatment. This idea is further supported by the wide variation in nanoparticle-mediated functional rescue, and highlights the need to assess rescue in every treated animal."}