PMC:2518050 / 35570-37020 JSONTXT

{"project":"0_colil","denotations":[{"id":"18982121-12048174-359894","span":{"begin":281,"end":285},"obj":"12048174"},{"id":"18982121-12195431-359895","span":{"begin":302,"end":306},"obj":"12195431"}],"text":"To determine if impaired hippocampal LTP in TgH1aV.Fb mice correlates with behavioral deficits, we trained wild-type and TgH1aV.Fb mice in spatial working and reference memory tasks. Spatial working memory was tested in a rewarded T-maze non-matching-to-place task (Deacon et al., 2002; Reisel et al., 2002). Each trial on this task consists of two runs, a sample run and a choice run. During the sample run, the mouse is directed to one of the two goal arms; on the subsequent choice run, it is rewarded if it chooses the previously unsampled arm (Figure 4A). Mice in this task have a natural tendency to alternate and enter the previously unvisited arm. Indeed, mice of both genotypes performed the task at better than chance (50%) already during the first block (wild-type = 76 ± 6% (mean ± SEM), N = 9; TgH1aV.Fb = 65 ± 5%; N = 12; Chi-square, P \u003c 0.001), and did not differ in this training phase (unpaired T-test, P = 0.14; Figure 4B). Training in the task for 80 trials (4 trials/session, 2 sessions/day for 5 consecutive days), improved the performance (two-way repeated ANOVA, F1,19 = 21.205, P \u003c 0.001) of wild-type (93 ± 2; paired T-test, P \u003c 0.05) but not TgH1aV.Fb mice (71 ± 5; paired T-test, P = 0.27; Figure 4C). At the end of the training, wild-type mice were significantly better than TgH1aV.Fb mice (unpaired T-test, P \u003c 0.005), indicating that sustained H1aV expression impairs acquisition of spatial working memory on the T-maze."}

{"project":"TEST0","denotations":[{"id":"18982121-98-106-359894","span":{"begin":281,"end":285},"obj":"[\"12048174\"]"},{"id":"18982121-119-127-359895","span":{"begin":302,"end":306},"obj":"[\"12195431\"]"}],"text":"To determine if impaired hippocampal LTP in TgH1aV.Fb mice correlates with behavioral deficits, we trained wild-type and TgH1aV.Fb mice in spatial working and reference memory tasks. Spatial working memory was tested in a rewarded T-maze non-matching-to-place task (Deacon et al., 2002; Reisel et al., 2002). Each trial on this task consists of two runs, a sample run and a choice run. During the sample run, the mouse is directed to one of the two goal arms; on the subsequent choice run, it is rewarded if it chooses the previously unsampled arm (Figure 4A). Mice in this task have a natural tendency to alternate and enter the previously unvisited arm. Indeed, mice of both genotypes performed the task at better than chance (50%) already during the first block (wild-type = 76 ± 6% (mean ± SEM), N = 9; TgH1aV.Fb = 65 ± 5%; N = 12; Chi-square, P \u003c 0.001), and did not differ in this training phase (unpaired T-test, P = 0.14; Figure 4B). Training in the task for 80 trials (4 trials/session, 2 sessions/day for 5 consecutive days), improved the performance (two-way repeated ANOVA, F1,19 = 21.205, P \u003c 0.001) of wild-type (93 ± 2; paired T-test, P \u003c 0.05) but not TgH1aV.Fb mice (71 ± 5; paired T-test, P = 0.27; Figure 4C). At the end of the training, wild-type mice were significantly better than TgH1aV.Fb mice (unpaired T-test, P \u003c 0.005), indicating that sustained H1aV expression impairs acquisition of spatial working memory on the T-maze."}

{"project":"2_test","denotations":[{"id":"18982121-12048174-38286639","span":{"begin":281,"end":285},"obj":"12048174"},{"id":"18982121-12195431-38286640","span":{"begin":302,"end":306},"obj":"12195431"}],"text":"To determine if impaired hippocampal LTP in TgH1aV.Fb mice correlates with behavioral deficits, we trained wild-type and TgH1aV.Fb mice in spatial working and reference memory tasks. Spatial working memory was tested in a rewarded T-maze non-matching-to-place task (Deacon et al., 2002; Reisel et al., 2002). Each trial on this task consists of two runs, a sample run and a choice run. During the sample run, the mouse is directed to one of the two goal arms; on the subsequent choice run, it is rewarded if it chooses the previously unsampled arm (Figure 4A). Mice in this task have a natural tendency to alternate and enter the previously unvisited arm. Indeed, mice of both genotypes performed the task at better than chance (50%) already during the first block (wild-type = 76 ± 6% (mean ± SEM), N = 9; TgH1aV.Fb = 65 ± 5%; N = 12; Chi-square, P \u003c 0.001), and did not differ in this training phase (unpaired T-test, P = 0.14; Figure 4B). Training in the task for 80 trials (4 trials/session, 2 sessions/day for 5 consecutive days), improved the performance (two-way repeated ANOVA, F1,19 = 21.205, P \u003c 0.001) of wild-type (93 ± 2; paired T-test, P \u003c 0.05) but not TgH1aV.Fb mice (71 ± 5; paired T-test, P = 0.27; Figure 4C). At the end of the training, wild-type mice were significantly better than TgH1aV.Fb mice (unpaired T-test, P \u003c 0.005), indicating that sustained H1aV expression impairs acquisition of spatial working memory on the T-maze."}