PMC:2222968 / 6098-6273 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2222968","sourcedb":"PMC","sourceid":"2222968","source_url":"http://www.ncbi.nlm.nih.gov/pmc/2222968","text":"We also show that GATA3 directly binds to the FOXP3 promoter and thereby prevents the induction of this gene, demonstrating that Th2 differentiation overrules iTreg induction.","tracks":[{"project":"pmc-enju-pas","denotations":[{"id":"T1554","span":{"begin":0,"end":2},"obj":"PRP"},{"id":"T1555","span":{"begin":3,"end":7},"obj":"RB"},{"id":"T1556","span":{"begin":8,"end":12},"obj":"VB"},{"id":"T1557","span":{"begin":13,"end":17},"obj":"IN"},{"id":"T1558","span":{"begin":18,"end":23},"obj":"NN"},{"id":"T1559","span":{"begin":24,"end":32},"obj":"RB"},{"id":"T1560","span":{"begin":33,"end":38},"obj":"VB"},{"id":"T1561","span":{"begin":39,"end":41},"obj":"TO"},{"id":"T1562","span":{"begin":42,"end":45},"obj":"DT"},{"id":"T1563","span":{"begin":46,"end":51},"obj":"NN"},{"id":"T1564","span":{"begin":52,"end":60},"obj":"NN"},{"id":"T1565","span":{"begin":61,"end":64},"obj":"CC"},{"id":"T1566","span":{"begin":65,"end":72},"obj":"RB"},{"id":"T1567","span":{"begin":73,"end":81},"obj":"VB"},{"id":"T1568","span":{"begin":82,"end":85},"obj":"DT"},{"id":"T1569","span":{"begin":86,"end":95},"obj":"NN"},{"id":"T1570","span":{"begin":96,"end":98},"obj":"IN"},{"id":"T1571","span":{"begin":99,"end":103},"obj":"DT"},{"id":"T1572","span":{"begin":104,"end":108},"obj":"NN"},{"id":"T1573","span":{"begin":108,"end":109},"obj":"-COMMA-"},{"id":"T1574","span":{"begin":110,"end":123},"obj":"VB"},{"id":"T1575","span":{"begin":124,"end":128},"obj":"IN"},{"id":"T1576","span":{"begin":129,"end":132},"obj":"NN"},{"id":"T1577","span":{"begin":133,"end":148},"obj":"NN"},{"id":"T1578","span":{"begin":149,"end":158},"obj":"VB"},{"id":"T1579","span":{"begin":159,"end":164},"obj":"NN"},{"id":"T1580","span":{"begin":165,"end":174},"obj":"NN"}],"relations":[{"id":"R1346","pred":"arg1Of","subj":"T1554","obj":"T1556"},{"id":"R1347","pred":"arg1Of","subj":"T1556","obj":"T1555"},{"id":"R1348","pred":"arg1Of","subj":"T1558","obj":"T1560"},{"id":"R1349","pred":"arg1Of","subj":"T1558","obj":"T1567"},{"id":"R1350","pred":"arg1Of","subj":"T1560","obj":"T1561"},{"id":"R1351","pred":"arg1Of","subj":"T1560","obj":"T1565"},{"id":"R1352","pred":"arg2Of","subj":"T1564","obj":"T1561"},{"id":"R1353","pred":"arg1Of","subj":"T1564","obj":"T1562"},{"id":"R1354","pred":"arg1Of","subj":"T1564","obj":"T1563"},{"id":"R1355","pred":"arg2Of","subj":"T1565","obj":"T1556"},{"id":"R1356","pred":"arg1Of","subj":"T1565","obj":"T1557"},{"id":"R1357","pred":"arg1Of","subj":"T1565","obj":"T1559"},{"id":"R1358","pred":"arg2Of","subj":"T1567","obj":"T1565"},{"id":"R1359","pred":"arg1Of","subj":"T1567","obj":"T1566"},{"id":"R1360","pred":"arg1Of","subj":"T1567","obj":"T1573"},{"id":"R1361","pred":"arg2Of","subj":"T1569","obj":"T1567"},{"id":"R1362","pred":"arg1Of","subj":"T1569","obj":"T1568"},{"id":"R1363","pred":"arg1Of","subj":"T1569","obj":"T1570"},{"id":"R1364","pred":"arg2Of","subj":"T1572","obj":"T1570"},{"id":"R1365","pred":"arg1Of","subj":"T1572","obj":"T1571"},{"id":"R1366","pred":"arg3Of","subj":"T1574","obj":"T1567"},{"id":"R1367","pred":"arg1Of","subj":"T1577","obj":"T1576"},{"id":"R1368","pred":"arg1Of","subj":"T1577","obj":"T1578"},{"id":"R1369","pred":"arg2Of","subj":"T1578","obj":"T1574"},{"id":"R1370","pred":"arg1Of","subj":"T1578","obj":"T1575"},{"id":"R1371","pred":"arg2Of","subj":"T1580","obj":"T1578"},{"id":"R1372","pred":"arg1Of","subj":"T1580","obj":"T1579"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"attributes":[{"subj":"T1554","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1555","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1556","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1557","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1558","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1559","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1560","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1561","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1562","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1563","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1564","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1565","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1566","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1567","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1568","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1569","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1570","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1571","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1572","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1573","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1574","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1575","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1576","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1577","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1578","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1579","pred":"source","obj":"pmc-enju-pas"},{"subj":"T1580","pred":"source","obj":"pmc-enju-pas"}]},{"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T1581","span":{"begin":99,"end":108},"obj":"Anaphor"},{"id":"T1582","span":{"begin":46,"end":51},"obj":"Antecedent"}],"relations":[{"id":"R1373","pred":"boundBy","subj":"T1581","obj":"T1582"}],"namespaces":[{"prefix":"_base","uri":"https://bionlp.dbcls.jp/ontology/ge.owl#"}],"attributes":[{"subj":"T1581","pred":"source","obj":"bionlp-st-ge-2016-coref"},{"subj":"T1582","pred":"source","obj":"bionlp-st-ge-2016-coref"}]},{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T2198","span":{"begin":0,"end":2},"obj":"PRP"},{"id":"T2199","span":{"begin":3,"end":7},"obj":"RB"},{"id":"T2200","span":{"begin":8,"end":12},"obj":"VBP"},{"id":"T2201","span":{"begin":13,"end":17},"obj":"IN"},{"id":"T2202","span":{"begin":18,"end":23},"obj":"CD"},{"id":"T2203","span":{"begin":24,"end":32},"obj":"RB"},{"id":"T2204","span":{"begin":33,"end":38},"obj":"VBZ"},{"id":"T2205","span":{"begin":39,"end":41},"obj":"TO"},{"id":"T2206","span":{"begin":42,"end":45},"obj":"DT"},{"id":"T2207","span":{"begin":46,"end":51},"obj":"CD"},{"id":"T2208","span":{"begin":52,"end":60},"obj":"NN"},{"id":"T2209","span":{"begin":61,"end":64},"obj":"CC"},{"id":"T2210","span":{"begin":65,"end":72},"obj":"RB"},{"id":"T2211","span":{"begin":73,"end":81},"obj":"VBZ"},{"id":"T2212","span":{"begin":82,"end":85},"obj":"DT"},{"id":"T2213","span":{"begin":86,"end":95},"obj":"NN"},{"id":"T2214","span":{"begin":96,"end":98},"obj":"IN"},{"id":"T2215","span":{"begin":99,"end":103},"obj":"DT"},{"id":"T2216","span":{"begin":104,"end":108},"obj":"NN"},{"id":"T2217","span":{"begin":108,"end":109},"obj":","},{"id":"T2218","span":{"begin":110,"end":123},"obj":"VBG"},{"id":"T2219","span":{"begin":124,"end":128},"obj":"IN"},{"id":"T2220","span":{"begin":129,"end":132},"obj":"JJ"},{"id":"T2221","span":{"begin":133,"end":148},"obj":"NN"},{"id":"T2222","span":{"begin":149,"end":158},"obj":"NNS"},{"id":"T2223","span":{"begin":159,"end":164},"obj":"NNP"},{"id":"T2224","span":{"begin":165,"end":174},"obj":"NN"},{"id":"T2225","span":{"begin":174,"end":175},"obj":"."}],"relations":[{"id":"R1941","pred":"nsubj","subj":"T2198","obj":"T2200"},{"id":"R1942","pred":"advmod","subj":"T2199","obj":"T2200"},{"id":"R1943","pred":"ROOT","subj":"T2200","obj":"T2200"},{"id":"R1944","pred":"mark","subj":"T2201","obj":"T2204"},{"id":"R1945","pred":"nsubj","subj":"T2202","obj":"T2204"},{"id":"R1946","pred":"advmod","subj":"T2203","obj":"T2204"},{"id":"R1947","pred":"ccomp","subj":"T2204","obj":"T2200"},{"id":"R1949","pred":"prep","subj":"T2205","obj":"T2204"},{"id":"R1950","pred":"det","subj":"T2206","obj":"T2208"},{"id":"R1951","pred":"nummod","subj":"T2207","obj":"T2208"},{"id":"R1952","pred":"pobj","subj":"T2208","obj":"T2205"},{"id":"R1953","pred":"cc","subj":"T2209","obj":"T2204"},{"id":"R1955","pred":"advmod","subj":"T2210","obj":"T2211"},{"id":"R1956","pred":"conj","subj":"T2211","obj":"T2204"},{"id":"R1957","pred":"det","subj":"T2212","obj":"T2213"},{"id":"R1959","pred":"dobj","subj":"T2213","obj":"T2211"},{"id":"R1960","pred":"prep","subj":"T2214","obj":"T2213"},{"id":"R1961","pred":"det","subj":"T2215","obj":"T2216"},{"id":"R1962","pred":"pobj","subj":"T2216","obj":"T2214"},{"id":"R1964","pred":"punct","subj":"T2217","obj":"T2200"},{"id":"R1966","pred":"advcl","subj":"T2218","obj":"T2200"},{"id":"R1967","pred":"mark","subj":"T2219","obj":"T2222"},{"id":"R1969","pred":"amod","subj":"T2220","obj":"T2221"},{"id":"R1970","pred":"nsubj","subj":"T2221","obj":"T2222"},{"id":"R1971","pred":"ccomp","subj":"T2222","obj":"T2218"},{"id":"R1972","pred":"compound","subj":"T2223","obj":"T2224"},{"id":"R1973","pred":"dobj","subj":"T2224","obj":"T2222"},{"id":"R1975","pred":"punct","subj":"T2225","obj":"T2200"}],"attributes":[{"subj":"T2198","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2199","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2200","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2201","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2202","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2203","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2204","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2205","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2206","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2207","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2208","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2209","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2210","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2211","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2212","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2213","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2214","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2215","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2216","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2217","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2218","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2219","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2220","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2221","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2222","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2223","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2224","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2225","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"}]},{"project":"sentences","denotations":[{"id":"T994","span":{"begin":0,"end":175},"obj":"Sentence"},{"id":"T41","span":{"begin":0,"end":175},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T994","pred":"source","obj":"sentences"},{"subj":"T41","pred":"source","obj":"sentences"}]},{"project":"events-check-again","denotations":[{"id":"T2566","span":{"begin":18,"end":23},"obj":"Protein"},{"id":"T2567","span":{"begin":33,"end":38},"obj":"Binding"},{"id":"T2568","span":{"begin":46,"end":51},"obj":"Protein"},{"id":"T2569","span":{"begin":52,"end":60},"obj":"Entity"},{"id":"T2570","span":{"begin":73,"end":81},"obj":"Negative_regulation"},{"id":"T2571","span":{"begin":86,"end":95},"obj":"Positive_regulation"}],"relations":[{"id":"R2158","pred":"themeOf","subj":"T2566","obj":"T2567"},{"id":"R2159","pred":"causeOf","subj":"T2567","obj":"T2570"},{"id":"R2161","pred":"themeOf","subj":"T2568","obj":"T2571"},{"id":"R2162","pred":"themeOf","subj":"T2569","obj":"T2567"},{"id":"R2163","pred":"partOf","subj":"T2569","obj":"T2568"},{"id":"R2165","pred":"themeOf","subj":"T2571","obj":"T2570"}],"attributes":[{"subj":"T2566","pred":"source","obj":"events-check-again"},{"subj":"T2567","pred":"source","obj":"events-check-again"},{"subj":"T2568","pred":"source","obj":"events-check-again"},{"subj":"T2569","pred":"source","obj":"events-check-again"},{"subj":"T2570","pred":"source","obj":"events-check-again"},{"subj":"T2571","pred":"source","obj":"events-check-again"}]},{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T2357","span":{"begin":18,"end":23},"obj":"Protein"},{"id":"T2358","span":{"begin":46,"end":60},"obj":"Protein"},{"id":"T2359","span":{"begin":33,"end":38},"obj":"Binding"}],"relations":[{"id":"R2045","pred":"themeOf","subj":"T2357","obj":"T2359"},{"id":"R2046","pred":"themeOf","subj":"T2358","obj":"T2359"}],"attributes":[{"subj":"T2357","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"},{"subj":"T2358","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"},{"subj":"T2359","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"}]},{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T971","span":{"begin":46,"end":51},"obj":"Protein"},{"id":"T972","span":{"begin":52,"end":60},"obj":"Entity"},{"id":"T973","span":{"begin":73,"end":81},"obj":"Negative_regulation"},{"id":"T974","span":{"begin":86,"end":95},"obj":"Positive_regulation"},{"id":"T969","span":{"begin":18,"end":23},"obj":"Protein"},{"id":"T970","span":{"begin":33,"end":38},"obj":"Binding"}],"relations":[{"id":"R764","pred":"themeOf","subj":"T969","obj":"T970"},{"id":"R765","pred":"causeOf","subj":"T970","obj":"T973"},{"id":"R766","pred":"themeOf","subj":"T971","obj":"T974"},{"id":"R767","pred":"themeOf","subj":"T972","obj":"T970"},{"id":"R768","pred":"partOf","subj":"T972","obj":"T971"},{"id":"R769","pred":"themeOf","subj":"T974","obj":"T973"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"attributes":[{"subj":"T971","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T972","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T973","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T974","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T969","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T970","pred":"source","obj":"bionlp-st-ge-2016-reference"}]},{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T1612","span":{"begin":18,"end":23},"obj":"P23771"},{"id":"T1613","span":{"begin":46,"end":51},"obj":"Q9BZS1"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"attributes":[{"subj":"T1612","pred":"source","obj":"bionlp-st-ge-2016-uniprot"},{"subj":"T1613","pred":"source","obj":"bionlp-st-ge-2016-uniprot"}]},{"project":"test2","denotations":[{"id":"T914","span":{"begin":18,"end":23},"obj":"Protein"},{"id":"T915","span":{"begin":33,"end":38},"obj":"Binding"},{"id":"T916","span":{"begin":46,"end":51},"obj":"Protein"},{"id":"T917","span":{"begin":52,"end":60},"obj":"Entity"}],"relations":[{"id":"R732","pred":"themeOf","subj":"T914","obj":"T915"},{"id":"R733","pred":"partOf","subj":"T917","obj":"T916"},{"id":"R734","pred":"themeOf","subj":"T917","obj":"T915"}],"attributes":[{"subj":"T914","pred":"source","obj":"test2"},{"subj":"T915","pred":"source","obj":"test2"},{"subj":"T916","pred":"source","obj":"test2"},{"subj":"T917","pred":"source","obj":"test2"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"pmc-enju-pas","color":"#aeec93","default":true},{"id":"bionlp-st-ge-2016-coref","color":"#ec93c8"},{"id":"bionlp-st-ge-2016-spacy-parsed","color":"#93e2ec"},{"id":"sentences","color":"#ecdc93"},{"id":"events-check-again","color":"#c293ec"},{"id":"bionlp-st-ge-2016-reference-tees","color":"#93eca8"},{"id":"bionlp-st-ge-2016-reference","color":"#ec9397"},{"id":"bionlp-st-ge-2016-uniprot","color":"#93b1ec"},{"id":"test2","color":"#ccec93"}]}]}}