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2_test

Id Subject Object Predicate Lexical cue
18162042-14597769-84705028 382-384 14597769 denotes 12
18162042-16617117-84705029 385-387 16617117 denotes 27
18162042-14676299-84705030 697-699 14676299 denotes 10
18162042-15100250-84705031 700-702 15100250 denotes 28
18162042-15659261-84705031 700-702 15659261 denotes 28
18162042-15232609-84705031 700-702 15232609 denotes 28
18162042-16244650-84705031 700-702 16244650 denotes 28
18162042-15237111-84705031 700-702 15237111 denotes 28
18162042-15795373-84705031 700-702 15795373 denotes 28
18162042-17298177-84705031 700-702 17298177 denotes 28
18162042-10761931-84705032 961-963 10761931 denotes 35
18162042-9160750-84705033 964-966 9160750 denotes 36
18162042-11045997-84705034 1287-1289 11045997 denotes 37
18162042-11009098-84705035 1290-1292 11009098 denotes 38
18162042-15577848-84705036 1677-1679 15577848 denotes 39
18162042-16517699-84705037 1690-1692 16517699 denotes 40
18162042-15294932-84705038 1710-1712 15294932 denotes 41
18162042-12524538-84705039 1765-1767 12524538 denotes 42
18162042-16237062-84705039 1765-1767 16237062 denotes 42
18162042-16476055-84705039 1765-1767 16476055 denotes 42
18162042-11544451-84705039 1765-1767 11544451 denotes 42
18162042-16484453-84705040 2274-2276 16484453 denotes 19
18162042-16200070-84705041 2977-2979 16200070 denotes 46
18162042-15944265-84705042 2980-2982 15944265 denotes 47
18162042-16473830-84705043 3180-3182 16473830 denotes 48
18162042-16648838-84705044 3183-3185 16648838 denotes 49
18162042-16237107-84705045 3387-3389 16237107 denotes 50
18162042-15944265-84705046 3670-3672 15944265 denotes 47
18162042-16645171-84705047 3741-3743 16645171 denotes 51
18162042-16121185-84705048 5183-5185 16121185 denotes 52
18162042-12871641-84705049 5442-5444 12871641 denotes 53
18162042-14769923-84705050 5445-5447 14769923 denotes 54
18162042-16943277-84705051 5554-5556 16943277 denotes 55
18162042-16517728-84705052 5907-5909 16517728 denotes 24
18162042-10880531-84705053 6436-6438 10880531 denotes 56
18162042-9160750-84705054 6480-6482 9160750 denotes 36
18162042-12648458-84705055 6560-6562 12648458 denotes 21
18162042-9801155-84705056 6563-6565 9801155 denotes 57
18162042-11579103-84705056 6563-6565 11579103 denotes 57
18162042-17075044-84705056 6563-6565 17075044 denotes 57
18162042-16517728-84705057 6867-6869 16517728 denotes 24
T86367 382-384 14597769 denotes 12
T42145 385-387 16617117 denotes 27
T19301 697-699 14676299 denotes 10
T33501 700-702 15100250 denotes 28
T60240 700-702 15659261 denotes 28
T94836 700-702 15232609 denotes 28
T79942 700-702 16244650 denotes 28
T22720 700-702 15237111 denotes 28
T18269 700-702 15795373 denotes 28
T10908 700-702 17298177 denotes 28
T74203 961-963 10761931 denotes 35
T72895 964-966 9160750 denotes 36
T39348 1287-1289 11045997 denotes 37
T26194 1290-1292 11009098 denotes 38
T18872 1677-1679 15577848 denotes 39
T75575 1690-1692 16517699 denotes 40
T60830 1710-1712 15294932 denotes 41
T52569 1765-1767 12524538 denotes 42
T47052 1765-1767 16237062 denotes 42
T12050 1765-1767 16476055 denotes 42
T38379 1765-1767 11544451 denotes 42
T23630 2274-2276 16484453 denotes 19
T81207 2977-2979 16200070 denotes 46
T96838 2980-2982 15944265 denotes 47
T27391 3180-3182 16473830 denotes 48
T74470 3183-3185 16648838 denotes 49
T49545 3387-3389 16237107 denotes 50
T48283 3670-3672 15944265 denotes 47
T69471 3741-3743 16645171 denotes 51
T40204 5183-5185 16121185 denotes 52
T35393 5442-5444 12871641 denotes 53
T74415 5445-5447 14769923 denotes 54
T84125 5554-5556 16943277 denotes 55
T5605 5907-5909 16517728 denotes 24
T14624 6436-6438 10880531 denotes 56
T18087 6480-6482 9160750 denotes 36
T24855 6560-6562 12648458 denotes 21
T68755 6563-6565 9801155 denotes 57
T99096 6563-6565 11579103 denotes 57
T56091 6563-6565 17075044 denotes 57
T4867 6867-6869 16517728 denotes 24

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T13704 11-14 DT denotes The
T13705 15-22 JJ denotes current
T13706 23-28 NN denotes study
T13707 29-36 VB denotes reveals
T13708 37-41 IN denotes that
T13709 42-47 NN denotes FOXP3
T13710 48-57 NN denotes induction
T13711 57-58 -COMMA- denotes ,
T13712 59-61 DT denotes an
T13713 62-71 JJ denotes important
T13714 72-76 NN denotes step
T13715 77-79 IN denotes in
T13716 80-85 NN denotes iTreg
T13717 86-96 NN denotes commitment
T13718 96-97 -COMMA- denotes ,
T13719 98-100 VB denotes is
T13720 101-110 VB denotes inhibited
T13721 111-113 IN denotes by
T13722 114-119 NN denotes GATA3
T13723 119-120 -COMMA- denotes ,
T13724 121-126 WDT denotes which
T13725 127-129 VB denotes is
T13726 130-133 DT denotes the
T13727 134-137 JJ denotes key
T13728 138-147 NN denotes regulator
T13729 148-151 IN denotes for
T13730 152-164 NN denotes polarization
T13731 165-171 IN denotes toward
T13732 172-175 NN denotes Th2
T13733 176-181 NN denotes cells
T13734 183-188 IN denotes After
T13735 189-204 NN denotes differentiation
T13736 204-205 -COMMA- denotes ,
T13737 206-209 DT denotes the
T13738 210-218 NN denotes effector
T13739 219-222 NN denotes Th2
T13740 223-228 NN denotes cells
T13741 229-235 VB denotes become
T13742 236-246 JJ denotes refractory
T13743 247-249 TO denotes to
T13744 250-260 NN denotes conversion
T13745 261-265 IN denotes into
T13746 266-267 DT denotes a
T13747 268-274 JJ denotes FOXP3+
T13748 275-284 NN denotes phenotype
T13749 286-288 IN denotes In
T13750 289-299 NN denotes accordance
T13751 300-304 IN denotes with
T13752 305-310 JJ denotes other
T13753 311-318 NN denotes studies
T13754 318-319 -COMMA- denotes ,
T13755 320-322 PRP denotes we
T13756 323-328 VB denotes found
T13757 329-333 IN denotes that
T13758 334-343 NN denotes CD4+CD25–
T13759 344-349 NN denotes cells
T13760 350-354 VB denotes were
T13761 355-359 JJ denotes able
T13762 360-362 TO denotes to
T13763 363-374 VB denotes up-regulate
T13764 375-380 NN denotes FOXP3
T13765 381-382 -LRB- denotes [
T13766 382-387 CD denotes 12,27
T13767 387-388 -RRB- denotes ]
T13768 390-407 JJ denotes Already-committed
T13769 408-413 NN denotes cells
T13770 414-418 JJ denotes such
T13771 419-421 IN denotes as
T13772 422-428 NN denotes memory
T13773 429-430 NN denotes T
T13774 431-436 NN denotes cells
T13775 437-440 CC denotes and
T13776 441-444 NN denotes Th1
T13777 445-450 NN denotes cells
T13778 451-457 VB denotes showed
T13779 458-462 RB denotes only
T13780 463-471 JJ denotes moderate
T13781 472-475 CC denotes and
T13782 476-485 JJ denotes transient
T13783 486-491 NN denotes FOXP3
T13784 492-501 NN denotes induction
T13785 501-502 -COMMA- denotes ,
T13786 503-508 WDT denotes which
T13787 509-511 VB denotes is
T13788 512-515 RB denotes not
T13789 516-526 JJ denotes sufficient
T13790 527-529 TO denotes to
T13791 530-536 VB denotes change
T13792 537-540 DT denotes the
T13793 541-550 NN denotes phenotype
T13794 551-557 IN denotes toward
T13795 558-559 DT denotes a
T13796 560-570 JJ denotes regulatory
T13797 571-572 NN denotes T
T13798 573-577 NN denotes cell
T13799 578-585 NN denotes profile
T13800 587-589 IN denotes In
T13801 590-598 NN denotes contrast
T13802 598-599 -COMMA- denotes ,
T13803 600-605 JJ denotes naive
T13804 606-607 NN denotes T
T13805 608-613 NN denotes cells
T13806 614-619 MD denotes could
T13807 620-631 RB denotes efficiently
T13808 632-643 VB denotes up-regulate
T13809 644-649 NN denotes FOXP3
T13810 650-654 WRB denotes when
T13811 655-662 VB denotes treated
T13812 663-667 IN denotes with
T13813 668-673 NN denotes TGF-β
T13814 674-676 TO denotes to
T13815 677-683 VB denotes induce
T13816 684-689 NN denotes iTreg
T13817 690-695 NN denotes cells
T13818 696-697 -LRB- denotes [
T13819 697-705 CD denotes 10,28–34
T13820 705-706 -RRB- denotes ]
T13821 706-707 -COMMA- denotes ,
T13822 708-718 VB denotes suggesting
T13823 719-723 IN denotes that
T13824 724-729 NN denotes FOXP3
T13825 730-735 VB denotes plays
T13826 736-738 DT denotes an
T13827 739-748 JJ denotes important
T13828 749-753 NN denotes role
T13829 754-756 IN denotes in
T13830 757-760 DT denotes the
T13831 761-766 JJ denotes early
T13832 767-782 NN denotes differentiation
T13833 783-790 NN denotes process
T13834 791-794 CC denotes and
T13835 795-798 MD denotes may
T13836 799-802 VB denotes act
T13837 803-805 IN denotes in
T13838 806-807 DT denotes a
T13839 808-811 NN denotes way
T13840 812-819 JJ denotes similar
T13841 820-822 TO denotes to
T13842 823-827 DT denotes that
T13843 828-833 VB denotes known
T13844 834-837 IN denotes for
T13845 838-841 DT denotes the
T13846 842-849 NN denotes Th1/Th2
T13847 850-858 NN denotes decision
T13848 859-866 NN denotes factors
T13849 867-872 NN denotes T-bet
T13850 873-876 CC denotes and
T13851 877-882 NN denotes GATA3
T13852 884-888 DT denotes This
T13853 889-899 NN denotes commitment
T13854 900-902 VB denotes is
T13855 903-916 VB denotes characterized
T13856 917-919 IN denotes by
T13857 920-931 JJ denotes competitive
T13858 932-942 NN denotes expression
T13859 943-945 IN denotes of
T13860 946-951 DT denotes these
T13861 952-959 NN denotes factors
T13862 960-961 -LRB- denotes [
T13863 961-966 CD denotes 35,36
T13864 966-967 -RRB- denotes ]
T13865 967-968 -COMMA- denotes ,
T13866 969-974 WDT denotes which
T13867 975-977 PRP denotes we
T13868 978-982 RB denotes also
T13869 983-991 VB denotes observed
T13870 992-994 IN denotes in
T13871 995-1010 VB denotes differentiating
T13872 1011-1017 JJ denotes FOXP3+
T13873 1018-1023 NN denotes iTreg
T13874 1024-1029 NN denotes cells
T13875 1030-1039 VB denotes including
T13876 1040-1041 DT denotes a
T13877 1042-1047 NN denotes phase
T13878 1048-1050 IN denotes of
T13879 1051-1064 NN denotes co-expression
T13880 1064-1065 -COMMA- denotes ,
T13881 1066-1071 WDT denotes which
T13882 1072-1077 VB denotes turns
T13883 1078-1082 IN denotes into
T13884 1083-1097 JJ denotes nonoverlapping
T13885 1098-1108 NN denotes expression
T13886 1109-1113 IN denotes upon
T13887 1114-1123 VB denotes completed
T13888 1124-1139 NN denotes differentiation
T13889 1141-1143 IN denotes In
T13890 1144-1148 DT denotes this
T13891 1149-1160 JJ denotes competitive
T13892 1161-1168 NN denotes process
T13893 1169-1174 NN denotes TGF-β
T13894 1175-1183 VB denotes appeared
T13895 1184-1186 TO denotes to
T13896 1187-1189 VB denotes be
T13897 1190-1199 JJ denotes mandatory
T13898 1200-1203 IN denotes for
T13899 1204-1207 DT denotes the
T13900 1208-1217 NN denotes induction
T13901 1218-1220 IN denotes of
T13902 1221-1226 NN denotes FOXP3
T13903 1226-1227 -COMMA- denotes ,
T13904 1228-1236 RB denotes possibly
T13905 1237-1239 IN denotes by
T13906 1240-1247 VB denotes keeping
T13907 1248-1251 DT denotes the
T13908 1252-1262 NN denotes expression
T13909 1263-1265 IN denotes of
T13910 1266-1271 NN denotes GATA3
T13911 1272-1275 CC denotes and
T13912 1276-1281 NN denotes T-bet
T13913 1282-1285 JJ denotes low
T13914 1286-1287 -LRB- denotes [
T13915 1287-1292 CD denotes 37,38
T13916 1292-1293 -RRB- denotes ]
T13917 1295-1297 IN denotes In
T13918 1298-1306 NN denotes contrast
T13919 1306-1307 -COMMA- denotes ,
T13920 1308-1323 VB denotes differentiating
T13921 1324-1329 JJ denotes naive
T13922 1330-1331 NN denotes T
T13923 1332-1337 NN denotes cells
T13924 1338-1340 IN denotes in
T13925 1341-1344 DT denotes the
T13926 1345-1352 NN denotes absence
T13927 1353-1355 IN denotes of
T13928 1356-1368 NN denotes polarization
T13929 1369-1376 NN denotes factors
T13930 1377-1378 -LRB- denotes (
T13931 1378-1381 NN denotes Th0
T13932 1381-1382 -RRB- denotes )
T13933 1383-1387 JJ denotes such
T13934 1388-1390 IN denotes as
T13935 1391-1395 NN denotes IL-4
T13936 1395-1396 -COMMA- denotes ,
T13937 1397-1402 NN denotes IL-12
T13938 1402-1403 -COMMA- denotes ,
T13939 1404-1406 CC denotes or
T13940 1407-1412 NN denotes TGF-β
T13941 1413-1419 VB denotes showed
T13942 1420-1424 RB denotes only
T13943 1425-1426 DT denotes a
T13944 1427-1436 JJ denotes transient
T13945 1437-1442 NN denotes FOXP3
T13946 1443-1453 NN denotes expression
T13947 1454-1457 CC denotes and
T13948 1458-1464 VB denotes failed
T13949 1465-1467 TO denotes to
T13950 1468-1476 VB denotes generate
T13951 1477-1478 DT denotes a
T13952 1479-1489 NN denotes population
T13953 1490-1492 IN denotes of
T13954 1493-1509 JJ denotes FOXP3-expressing
T13955 1510-1515 NN denotes cells
T13956 1515-1516 -COMMA- denotes ,
T13957 1517-1520 CC denotes but
T13958 1521-1526 NN denotes GATA3
T13959 1527-1530 CC denotes and
T13960 1531-1536 NN denotes T-bet
T13961 1537-1541 VB denotes were
T13962 1542-1554 VB denotes up-regulated
T13963 1555-1556 -LRB- denotes (
T13964 1556-1567 JJ denotes unpublished
T13965 1568-1572 NN denotes data
T13966 1572-1573 -RRB- denotes )
T13967 1575-1588 RB denotes Interestingly
T13968 1588-1589 -COMMA- denotes ,
T13969 1590-1592 IN denotes as
T13970 1593-1595 PRP denotes we
T13971 1596-1599 CC denotes and
T13972 1600-1606 NN denotes others
T13973 1607-1617 RB denotes previously
T13974 1618-1627 VB denotes described
T13975 1627-1628 -COMMA- denotes ,
T13976 1629-1644 JJ denotes FOXP3-promoting
T13977 1645-1652 NN denotes factors
T13978 1652-1653 -COMMA- denotes ,
T13979 1654-1658 JJ denotes such
T13980 1659-1661 IN denotes as
T13981 1662-1675 NN denotes dexamethasone
T13982 1676-1677 -LRB- denotes [
T13983 1677-1679 CD denotes 39
T13984 1679-1680 -RRB- denotes ]
T13985 1680-1681 -COMMA- denotes ,
T13986 1682-1688 NN denotes CTLA-4
T13987 1689-1690 -LRB- denotes [
T13988 1690-1692 CD denotes 40
T13989 1692-1693 -RRB- denotes ]
T13990 1693-1694 -COMMA- denotes ,
T13991 1695-1698 CC denotes and
T13992 1699-1708 NN denotes estrogens
T13993 1709-1710 -LRB- denotes [
T13994 1710-1712 CD denotes 41
T13995 1712-1713 -RRB- denotes ]
T13996 1713-1714 -COMMA- denotes ,
T13997 1715-1718 VB denotes are
T13998 1719-1723 RB denotes also
T13999 1724-1729 VB denotes known
T14000 1730-1732 IN denotes as
T14001 1733-1743 NN denotes inhibitors
T14002 1744-1746 IN denotes of
T14003 1747-1752 NN denotes GATA3
T14004 1753-1763 NN denotes expression
T14005 1764-1765 -LRB- denotes [
T14006 1765-1770 CD denotes 42–45
T14007 1770-1771 -RRB- denotes ]
T14008 1773-1782 RB denotes Therefore
T14009 1783-1788 NN denotes GATA3
T14010 1789-1792 RB denotes not
T14011 1793-1797 RB denotes only
T14012 1798-1805 VB denotes induces
T14013 1806-1821 NN denotes differentiation
T14014 1822-1826 IN denotes into
T14015 1827-1830 NN denotes Th2
T14016 1831-1836 NN denotes cells
T14017 1837-1840 CC denotes but
T14018 1841-1845 RB denotes also
T14019 1846-1854 VB denotes inhibits
T14020 1855-1860 NN denotes FOXP3
T14021 1861-1871 NN denotes expression
T14022 1872-1875 CC denotes and
T14023 1876-1886 NN denotes commitment
T14024 1887-1891 IN denotes into
T14025 1892-1897 NN denotes iTreg
T14026 1898-1903 NN denotes cells
T14027 1905-1908 DT denotes The
T14028 1909-1912 NN denotes Th2
T14029 1913-1921 NN denotes cytokine
T14030 1922-1926 NN denotes IL-4
T14031 1927-1930 CC denotes but
T14032 1931-1934 RB denotes not
T14033 1935-1940 NN denotes IL-13
T14034 1941-1942 -LRB- denotes (
T14035 1942-1953 JJ denotes unpublished
T14036 1954-1958 NN denotes data
T14037 1958-1959 -RRB- denotes )
T14038 1960-1963 VB denotes was
T14039 1964-1968 JJ denotes able
T14040 1969-1971 TO denotes to
T14041 1972-1979 VB denotes inhibit
T14042 1980-1994 JJ denotes TGF-β–mediated
T14043 1995-2000 NN denotes FOXP3
T14044 2001-2010 NN denotes induction
T14045 2011-2014 CC denotes and
T14046 2015-2024 RB denotes therefore
T14047 2025-2034 VB denotes prevented
T14048 2035-2045 NN denotes conversion
T14049 2046-2050 IN denotes into
T14050 2051-2054 DT denotes the
T14051 2055-2065 JJ denotes regulatory
T14052 2066-2075 NN denotes phenotype
T14053 2077-2079 TO denotes To
T14054 2080-2085 VB denotes prove
T14055 2086-2089 DT denotes the
T14056 2090-2100 JJ denotes inhibitory
T14057 2101-2107 NN denotes effect
T14058 2108-2110 IN denotes of
T14059 2111-2115 NN denotes IL-4
T14060 2116-2118 IN denotes on
T14061 2119-2128 JJ denotes inducible
T14062 2129-2131 CC denotes or
T14063 2132-2139 JJ denotes natural
T14064 2140-2144 NN denotes Treg
T14065 2145-2155 NN denotes commitment
T14066 2156-2158 FW denotes in
T14067 2159-2163 FW denotes vivo
T14068 2163-2164 -COMMA- denotes ,
T14069 2165-2167 PRP denotes we
T14070 2168-2175 VB denotes treated
T14071 2176-2180 NN denotes mice
T14072 2181-2185 IN denotes with
T14073 2186-2190 NN denotes IL-4
T14074 2191-2194 CC denotes and
T14075 2195-2204 NN denotes anti-IL-4
T14076 2206-2210 DT denotes This
T14077 2211-2214 VB denotes has
T14078 2215-2219 VB denotes been
T14079 2220-2225 VB denotes shown
T14080 2226-2228 TO denotes to
T14081 2229-2237 VB denotes increase
T14082 2238-2241 DT denotes the
T14083 2242-2248 NN denotes effect
T14084 2249-2251 IN denotes of
T14085 2252-2255 DT denotes the
T14086 2256-2264 NN denotes cytokine
T14087 2265-2267 FW denotes in
T14088 2268-2272 FW denotes vivo
T14089 2273-2274 -LRB- denotes [
T14090 2274-2276 CD denotes 19
T14091 2276-2277 -RRB- denotes ]
T14092 2279-2283 RB denotes Only
T14093 2284-2287 DT denotes the
T14094 2288-2297 NN denotes IL-4/IL-4
T14095 2298-2301 NN denotes mAb
T14096 2302-2309 NN denotes complex
T14097 2310-2318 VB denotes resulted
T14098 2319-2321 IN denotes in
T14099 2322-2323 DT denotes a
T14100 2324-2332 NN denotes decrease
T14101 2333-2335 IN denotes of
T14102 2336-2339 DT denotes the
T14103 2340-2346 NN denotes amount
T14104 2347-2349 IN denotes of
T14105 2350-2357 JJ denotes natural
T14106 2358-2360 CC denotes or
T14107 2361-2370 JJ denotes inducible
T14108 2371-2375 NN denotes Treg
T14109 2376-2377 -LRB- denotes (
T14110 2377-2382 JJ denotes CD25+
T14111 2383-2386 CC denotes and
T14112 2387-2393 JJ denotes Foxp3+
T14113 2393-2394 -RRB- denotes )
T14114 2395-2400 NN denotes cells
T14115 2401-2402 CD denotes 7
T14116 2403-2404 NN denotes d
T14117 2405-2410 IN denotes after
T14118 2411-2420 NN denotes treatment
T14119 2422-2425 PRP-DOLLAR- denotes Our
T14120 2426-2433 NN denotes results
T14121 2434-2441 VB denotes suggest
T14122 2442-2446 IN denotes that
T14123 2447-2451 NN denotes IL-4
T14124 2452-2454 VB denotes is
T14125 2455-2459 RB denotes only
T14126 2460-2471 VB denotes interfering
T14127 2472-2476 IN denotes with
T14128 2477-2480 DT denotes the
T14129 2481-2496 NN denotes differentiation
T14130 2497-2499 IN denotes of
T14131 2500-2505 JJ denotes naive
T14132 2506-2507 NN denotes T
T14133 2508-2513 NN denotes cells
T14134 2514-2518 IN denotes into
T14135 2519-2524 NN denotes iTreg
T14136 2525-2530 NN denotes cells
T14137 2532-2535 CC denotes But
T14138 2536-2541 IN denotes since
T14139 2542-2543 DT denotes a
T14140 2544-2555 NN denotes distinction
T14141 2556-2558 IN denotes of
T14142 2559-2564 NN denotes nTreg
T14143 2565-2568 CC denotes and
T14144 2569-2574 NN denotes iTreg
T14145 2575-2580 NN denotes cells
T14146 2581-2583 VB denotes is
T14147 2584-2593 RB denotes currently
T14148 2594-2597 RB denotes not
T14149 2598-2606 JJ denotes possible
T14150 2606-2607 -COMMA- denotes ,
T14151 2608-2615 IN denotes because
T14152 2616-2621 NN denotes iTreg
T14153 2622-2627 NN denotes cells
T14154 2628-2632 RB denotes also
T14155 2633-2644 RB denotes transiently
T14156 2645-2652 VB denotes express
T14157 2653-2657 NN denotes CD25
T14158 2658-2663 IN denotes after
T14159 2664-2674 NN denotes activation
T14160 2674-2675 -COMMA- denotes ,
T14161 2676-2678 PRP denotes we
T14162 2679-2682 MD denotes can
T14163 2682-2685 RB denotes not
T14164 2686-2693 VB denotes exclude
T14165 2694-2698 DT denotes that
T14166 2699-2703 NN denotes IL-4
T14167 2704-2707 MD denotes may
T14168 2708-2712 RB denotes also
T14169 2713-2720 VB denotes inhibit
T14170 2721-2726 NN denotes Foxp3
T14171 2727-2737 NN denotes expression
T14172 2738-2740 IN denotes in
T14173 2741-2746 NN denotes nTreg
T14174 2747-2752 NN denotes cells
T14175 2753-2755 FW denotes in
T14176 2756-2760 FW denotes vivo
T14177 2761-2763 CC denotes or
T14178 2764-2768 IN denotes that
T14179 2769-2779 JJ denotes additional
T14180 2780-2787 NN denotes effects
T14181 2788-2791 MD denotes may
T14182 2792-2802 VB denotes contribute
T14183 2803-2805 TO denotes to
T14184 2806-2809 DT denotes the
T14185 2810-2818 VB denotes observed
T14186 2819-2823 NN denotes drop
T14187 2824-2826 IN denotes in
T14188 2827-2832 NN denotes Foxp3
T14189 2833-2843 NN denotes expression
T14190 2845-2849 NN denotes IL-4
T14191 2850-2853 VB denotes has
T14192 2854-2861 RB denotes already
T14193 2862-2866 VB denotes been
T14194 2867-2872 VB denotes shown
T14195 2873-2875 TO denotes to
T14196 2876-2886 RB denotes negatively
T14197 2887-2895 VB denotes regulate
T14198 2896-2899 DT denotes the
T14199 2900-2911 NN denotes development
T14200 2912-2914 IN denotes of
T14201 2915-2920 JJ denotes naive
T14202 2921-2922 NN denotes T
T14203 2923-2928 NN denotes cells
T14204 2929-2933 IN denotes into
T14205 2934-2937 NN denotes Th1
T14206 2938-2940 CC denotes or
T14207 2941-2944 DT denotes the
T14208 2945-2960 JJ denotes IL-17–producing
T14209 2961-2962 NN denotes T
T14210 2963-2968 NN denotes cells
T14211 2969-2970 -LRB- denotes (
T14212 2970-2974 NN denotes Th17
T14213 2974-2975 -RRB- denotes )
T14214 2976-2977 -LRB- denotes [
T14215 2977-2982 CD denotes 46,47
T14216 2982-2983 -RRB- denotes ]
T14217 2985-2992 JJ denotes Similar
T14218 2993-3000 NN denotes effects
T14219 3001-3005 VB denotes have
T14220 3006-3010 VB denotes been
T14221 3011-3019 RB denotes recently
T14222 3020-3029 VB denotes described
T14223 3030-3033 IN denotes for
T14224 3034-3038 NN denotes IL-6
T14225 3038-3039 -COMMA- denotes ,
T14226 3040-3045 WDT denotes which
T14227 3045-3046 -COMMA- denotes ,
T14228 3047-3055 VB denotes combined
T14229 3056-3060 IN denotes with
T14230 3061-3066 NN denotes TGF-β
T14231 3066-3067 -COMMA- denotes ,
T14232 3068-3076 VB denotes inhibits
T14233 3077-3080 DT denotes the
T14234 3081-3091 NN denotes generation
T14235 3092-3094 IN denotes of
T14236 3095-3100 NN denotes iTreg
T14237 3101-3106 NN denotes cells
T14238 3107-3110 CC denotes and
T14239 3111-3118 VB denotes induces
T14240 3119-3134 NN denotes differentiation
T14241 3135-3139 IN denotes into
T14242 3140-3143 DT denotes the
T14243 3144-3148 NN denotes Th17
T14244 3149-3154 NN denotes cells
T14245 3155-3157 IN denotes by
T14246 3158-3160 DT denotes an
T14247 3161-3168 JJ denotes unknown
T14248 3169-3178 NN denotes mechanism
T14249 3179-3180 -LRB- denotes [
T14250 3180-3185 CD denotes 48,49
T14251 3185-3186 -RRB- denotes ]
T14252 3188-3192 RB denotes Thus
T14253 3193-3196 DT denotes the
T14254 3197-3209 NN denotes polarization
T14255 3210-3214 IN denotes into
T14256 3215-3220 NN denotes iTreg
T14257 3221-3226 NN denotes cells
T14258 3227-3229 VB denotes is
T14259 3230-3240 RB denotes negatively
T14260 3241-3250 VB denotes regulated
T14261 3251-3253 IN denotes by
T14262 3254-3257 DT denotes the
T14263 3258-3266 NN denotes effector
T14264 3267-3276 NN denotes cytokines
T14265 3277-3281 NN denotes IL-4
T14266 3282-3285 CC denotes and
T14267 3286-3290 NN denotes IL-6
T14268 3292-3296 NN denotes IL-4
T14269 3297-3300 VB denotes has
T14270 3301-3305 VB denotes been
T14271 3306-3316 RB denotes previously
T14272 3317-3322 VB denotes shown
T14273 3323-3325 TO denotes to
T14274 3326-3332 VB denotes induce
T14275 3333-3336 DT denotes the
T14276 3337-3347 NN denotes generation
T14277 3348-3350 IN denotes of
T14278 3351-3357 JJ denotes FOXP3+
T14279 3358-3362 NN denotes Treg
T14280 3363-3368 NN denotes cells
T14281 3369-3372 IN denotes out
T14282 3373-3375 IN denotes of
T14283 3376-3385 NN denotes CD4+CD25–
T14284 3386-3387 -LRB- denotes [
T14285 3387-3389 CD denotes 50
T14286 3389-3390 -RRB- denotes ]
T14287 3392-3394 IN denotes In
T14288 3395-3400 DT denotes those
T14289 3401-3412 NN denotes experiments
T14290 3412-3413 -COMMA- denotes ,
T14291 3414-3417 DT denotes the
T14292 3418-3432 NN denotes concentrations
T14293 3433-3435 IN denotes of
T14294 3436-3440 NN denotes IL-4
T14295 3441-3445 VB denotes used
T14296 3446-3450 VB denotes were
T14297 3451-3454 JJ denotes low
T14298 3454-3455 -COMMA- denotes ,
T14299 3456-3459 CC denotes and
T14300 3460-3462 IN denotes as
T14301 3463-3465 PRP denotes we
T14302 3466-3470 RB denotes also
T14303 3471-3479 VB denotes observed
T14304 3479-3480 -COMMA- denotes ,
T14305 3481-3485 NN denotes IL-4
T14306 3486-3488 IN denotes at
T14307 3489-3492 JJ denotes low
T14308 3493-3506 NN denotes concentration
T14309 3507-3515 RB denotes slightly
T14310 3516-3524 VB denotes enhanced
T14311 3525-3530 NN denotes FOXP3
T14312 3531-3541 NN denotes expression
T14313 3543-3554 RB denotes Importantly
T14314 3554-3555 -COMMA- denotes ,
T14315 3556-3561 DT denotes these
T14316 3562-3576 NN denotes concentrations
T14317 3577-3581 VB denotes were
T14318 3582-3585 RB denotes not
T14319 3586-3596 JJ denotes sufficient
T14320 3597-3599 TO denotes to
T14321 3600-3606 VB denotes induce
T14322 3607-3612 NN denotes GATA3
T14323 3613-3623 NN denotes expression
T14324 3625-3629 NN denotes IL-4
T14325 3630-3633 MD denotes may
T14326 3634-3639 VB denotes favor
T14327 3640-3653 NN denotes proliferation
T14328 3654-3656 IN denotes of
T14329 3657-3662 NN denotes nTreg
T14330 3663-3668 NN denotes cells
T14331 3669-3670 -LRB- denotes [
T14332 3670-3672 CD denotes 47
T14333 3672-3673 -RRB- denotes ]
T14334 3674-3676 CC denotes or
T14335 3677-3685 RB denotes directly
T14336 3686-3694 VB denotes regulate
T14337 3695-3700 NN denotes FOXP3
T14338 3701-3711 NN denotes expression
T14339 3712-3714 IN denotes in
T14340 3715-3716 DT denotes a
T14341 3717-3731 JJ denotes STAT-dependent
T14342 3732-3739 NN denotes fashion
T14343 3740-3741 -LRB- denotes [
T14344 3741-3743 CD denotes 51
T14345 3743-3744 -RRB- denotes ]
T14346 3746-3751 IN denotes Since
T14347 3752-3757 NN denotes IL-13
T14348 3758-3762 VB denotes does
T14349 3763-3766 RB denotes not
T14350 3767-3778 RB denotes effectively
T14351 3779-3785 VB denotes reduce
T14352 3786-3791 NN denotes FOXP3
T14353 3792-3795 CC denotes and
T14354 3796-3801 VB denotes fails
T14355 3802-3804 TO denotes to
T14356 3805-3811 VB denotes induce
T14357 3812-3817 NN denotes GATA3
T14358 3817-3818 -COMMA- denotes ,
T14359 3819-3821 PRP denotes we
T14360 3822-3834 VB denotes hypothesized
T14361 3835-3839 IN denotes that
T14362 3840-3843 DT denotes the
T14363 3844-3858 JJ denotes IL-4–dependent
T14364 3859-3869 NN denotes inhibition
T14365 3870-3872 IN denotes of
T14366 3873-3878 NN denotes FOXP3
T14367 3879-3884 MD denotes could
T14368 3885-3887 VB denotes be
T14369 3888-3896 VB denotes mediated
T14370 3897-3899 IN denotes by
T14371 3900-3905 NN denotes GATA3
T14372 3907-3909 IN denotes In
T14373 3910-3914 NN denotes fact
T14374 3914-3915 -COMMA- denotes ,
T14375 3916-3930 JJ denotes GATA3-inducing
T14376 3931-3935 NN denotes IL-4
T14377 3936-3950 NN denotes concentrations
T14378 3951-3960 VB denotes repressed
T14379 3961-3975 JJ denotes TGF-β–mediated
T14380 3976-3981 NN denotes FOXP3
T14381 3982-3992 NN denotes expression
T14382 3992-3993 -COMMA- denotes ,
T14383 3994-4001 IN denotes whereas
T14384 4002-4006 NN denotes IL-4
T14385 4007-4009 RB denotes as
T14386 4010-4014 RB denotes well
T14387 4015-4017 IN denotes as
T14388 4018-4023 NN denotes TGF-β
T14389 4024-4033 NN denotes signaling
T14390 4034-4038 VB denotes were
T14391 4039-4045 JJ denotes intact
T14392 4047-4051 DT denotes This
T14393 4052-4058 NN denotes result
T14394 4059-4068 VB denotes suggested
T14395 4069-4070 DT denotes a
T14396 4071-4082 JJ denotes competitive
T14397 4083-4092 NN denotes mechanism
T14398 4093-4100 IN denotes between
T14399 4101-4106 NN denotes GATA3
T14400 4107-4110 CC denotes and
T14401 4111-4116 NN denotes FOXP3
T14402 4117-4130 NN denotes transcription
T14403 4131-4138 NN denotes factors
T14404 4139-4141 IN denotes in
T14405 4142-4153 VB denotes determining
T14406 4154-4161 NN denotes lineage
T14407 4162-4172 NN denotes commitment
T14408 4173-4179 IN denotes during
T14409 4180-4183 DT denotes the
T14410 4184-4189 JJ denotes early
T14411 4190-4195 NN denotes phase
T14412 4196-4198 IN denotes of
T14413 4199-4214 NN denotes differentiation
T14414 4216-4227 RB denotes Accordingly
T14415 4227-4228 -COMMA- denotes ,
T14416 4229-4231 PRP denotes we
T14417 4232-4244 VB denotes investigated
T14418 4245-4254 RB denotes naturally
T14419 4255-4259 JJ denotes high
T14420 4260-4276 NN denotes GATA3-expressing
T14421 4277-4282 NN denotes cells
T14422 4283-4286 CC denotes and
T14423 4287-4296 VB denotes confirmed
T14424 4297-4300 DT denotes the
T14425 4301-4308 NN denotes absence
T14426 4309-4311 IN denotes of
T14427 4312-4317 NN denotes FOXP3
T14428 4319-4326 NN denotes Protein
T14429 4327-4339 NN denotes transduction
T14430 4340-4342 IN denotes of
T14431 4343-4348 NN denotes GATA3
T14432 4349-4353 IN denotes into
T14433 4354-4359 JJ denotes naive
T14434 4360-4361 NN denotes T
T14435 4362-4367 NN denotes cells
T14436 4368-4377 VB denotes inhibited
T14437 4378-4383 NN denotes FOXP3
T14438 4384-4393 NN denotes induction
T14439 4394-4396 IN denotes in
T14440 4397-4402 JJ denotes human
T14441 4402-4403 -COMMA- denotes ,
T14442 4404-4419 VB denotes differentiating
T14443 4419-4420 -COMMA- denotes ,
T14444 4421-4426 JJ denotes naive
T14445 4427-4428 NN denotes T
T14446 4429-4434 NN denotes cells
T14447 4436-4440 DT denotes This
T14448 4441-4451 JJ denotes inhibitory
T14449 4452-4458 NN denotes effect
T14450 4459-4461 IN denotes of
T14451 4462-4467 NN denotes GATA3
T14452 4468-4471 VB denotes was
T14453 4472-4479 RB denotes further
T14454 4480-4489 VB denotes confirmed
T14455 4490-4492 IN denotes in
T14456 4493-4499 NN denotes BALB/c
T14457 4500-4510 JJ denotes transgenic
T14458 4511-4515 NN denotes mice
T14459 4515-4516 -COMMA- denotes ,
T14460 4517-4527 VB denotes expressing
T14461 4528-4533 NN denotes GATA3
T14462 4534-4536 IN denotes in
T14463 4537-4538 NN denotes T
T14464 4539-4544 NN denotes cells
T14465 4545-4546 -LRB- denotes (
T14466 4546-4553 NN denotes DO11.10
T14467 4553-4554 -COLON- denotes :
T14468 4554-4563 JJ denotes CD2-GATA3
T14469 4564-4574 JJ denotes transgenic
T14470 4575-4579 NN denotes mice
T14471 4579-4580 -RRB- denotes )
T14472 4582-4584 IN denotes In
T14473 4585-4589 NN denotes line
T14474 4590-4594 IN denotes with
T14475 4595-4598 DT denotes the
T14476 4599-4608 JJ denotes transient
T14477 4609-4623 NN denotes overexpression
T14478 4624-4626 IN denotes of
T14479 4627-4632 NN denotes GATA3
T14480 4633-4635 IN denotes in
T14481 4636-4641 JJ denotes human
T14482 4642-4643 NN denotes T
T14483 4644-4649 NN denotes cells
T14484 4649-4650 -COMMA- denotes ,
T14485 4651-4656 NN denotes cells
T14486 4657-4659 IN denotes of
T14487 4660-4665 DT denotes these
T14488 4666-4670 NN denotes mice
T14489 4671-4677 VB denotes failed
T14490 4678-4680 TO denotes to
T14491 4681-4687 VB denotes induce
T14492 4688-4693 NN denotes FOXP3
T14493 4694-4704 NN denotes expression
T14494 4705-4709 IN denotes upon
T14495 4710-4718 NN denotes exposure
T14496 4719-4723 IN denotes with
T14497 4724-4731 NN denotes antigen
T14498 4732-4734 IN denotes in
T14499 4735-4738 DT denotes the
T14500 4739-4747 NN denotes presence
T14501 4748-4750 IN denotes of
T14502 4751-4756 NN denotes TGF-β
T14503 4758-4768 RB denotes Strikingly
T14504 4768-4769 -COMMA- denotes ,
T14505 4770-4773 DT denotes the
T14506 4774-4781 NN denotes DO11.10
T14507 4781-4782 -COLON- denotes :
T14508 4782-4791 NN denotes CD2-GATA3
T14509 4792-4796 NN denotes mice
T14510 4797-4799 VB denotes do
T14511 4800-4804 VB denotes have
T14512 4805-4815 JJ denotes peripheral
T14513 4816-4822 JJ denotes FOXP3+
T14514 4823-4828 NN denotes cells
T14515 4828-4829 -COMMA- denotes ,
T14516 4830-4835 WDT denotes which
T14517 4836-4843 RB denotes however
T14518 4844-4853 VB denotes displayed
T14519 4854-4855 DT denotes a
T14520 4856-4858 CD denotes 10
T14521 4858-4859 NN denotes %
T14522 4859-4862 CD denotes –25
T14523 4862-4863 NN denotes %
T14524 4864-4869 JJ denotes lower
T14525 4870-4879 NN denotes frequency
T14526 4880-4888 VB denotes compared
T14527 4889-4891 TO denotes to
T14528 4892-4901 JJ denotes wild-type
T14529 4902-4909 NN denotes DO11.10
T14530 4910-4914 NN denotes mice
T14531 4916-4920 RB denotes Thus
T14532 4921-4926 NN denotes GATA3
T14533 4927-4936 VB denotes restrains
T14534 4937-4940 DT denotes the
T14535 4941-4952 NN denotes development
T14536 4953-4955 IN denotes of
T14537 4956-4963 JJ denotes certain
T14538 4964-4968 NN denotes Treg
T14539 4969-4976 NN denotes subsets
T14540 4976-4977 -COMMA- denotes ,
T14541 4978-4988 RB denotes presumably
T14542 4989-4992 DT denotes the
T14543 4993-5002 JJ denotes inducible
T14544 5002-5003 -COMMA- denotes ,
T14545 5004-5014 JJ denotes peripheral
T14546 5015-5025 NN denotes population
T14547 5026-5029 CC denotes and
T14548 5030-5033 RB denotes not
T14549 5034-5039 DT denotes those
T14550 5040-5042 IN denotes of
T14551 5043-5049 JJ denotes thymic
T14552 5050-5056 NN denotes origin
T14553 5058-5064 JJ denotes Thymic
T14554 5065-5066 NN denotes T
T14555 5067-5072 NN denotes cells
T14556 5073-5080 VB denotes undergo
T14557 5081-5082 DT denotes a
T14558 5083-5092 JJ denotes different
T14559 5093-5103 NN denotes maturation
T14560 5104-5111 NN denotes process
T14561 5111-5112 -COMMA- denotes ,
T14562 5113-5118 WDT denotes which
T14563 5119-5122 MD denotes may
T14564 5123-5130 VB denotes explain
T14565 5131-5134 DT denotes the
T14566 5135-5148 NN denotes insensitivity
T14567 5149-5151 IN denotes of
T14568 5152-5157 NN denotes nTreg
T14569 5158-5160 TO denotes to
T14570 5161-5166 NN denotes GATA3
T14571 5167-5181 NN denotes overexpression
T14572 5182-5183 -LRB- denotes [
T14573 5183-5185 CD denotes 52
T14574 5185-5186 -RRB- denotes ]
T14575 5188-5190 IN denotes In
T14576 5191-5199 NN denotes contrast
T14577 5200-5202 TO denotes to
T14578 5203-5206 DT denotes the
T14579 5207-5226 JJ denotes Th2-differentiating
T14580 5227-5230 CC denotes and
T14581 5231-5247 JJ denotes iTreg-inhibiting
T14582 5248-5256 NN denotes function
T14583 5257-5259 IN denotes of
T14584 5260-5265 NN denotes GATA3
T14585 5266-5268 IN denotes in
T14586 5269-5279 JJ denotes peripheral
T14587 5280-5281 NN denotes T
T14588 5282-5287 NN denotes cells
T14589 5287-5288 -COMMA- denotes ,
T14590 5289-5294 NN denotes GATA3
T14591 5295-5299 VB denotes acts
T14592 5300-5302 IN denotes in
T14593 5303-5306 DT denotes the
T14594 5307-5313 NN denotes thymus
T14595 5314-5322 RB denotes together
T14596 5323-5327 IN denotes with
T14597 5328-5333 JJ denotes other
T14598 5334-5347 NN denotes transcription
T14599 5348-5355 NN denotes factors
T14600 5356-5360 JJ denotes such
T14601 5361-5363 IN denotes as
T14602 5364-5367 DT denotes the
T14603 5368-5377 NNP denotes Repressor
T14604 5378-5380 IN denotes of
T14605 5381-5386 NN denotes GATA3
T14606 5387-5388 -LRB- denotes (
T14607 5388-5391 NN denotes ROG
T14608 5391-5392 -RRB- denotes )
T14609 5393-5395 IN denotes in
T14610 5396-5399 DT denotes the
T14611 5400-5415 NN denotes differentiation
T14612 5416-5423 NN denotes process
T14613 5424-5430 IN denotes toward
T14614 5431-5434 NN denotes CD8
T14615 5435-5440 NN denotes cells
T14616 5441-5442 -LRB- denotes [
T14617 5442-5447 CD denotes 53,54
T14618 5447-5448 -RRB- denotes ]
T14619 5449-5451 CC denotes or
T14620 5452-5464 VB denotes participates
T14621 5465-5467 IN denotes in
T14622 5468-5475 JJ denotes complex
T14623 5476-5491 JJ denotes transcriptional
T14624 5492-5500 NN denotes feedback
T14625 5501-5508 NN denotes network
T14626 5509-5511 TO denotes to
T14627 5512-5520 VB denotes regulate
T14628 5521-5536 JJ denotes sympathoadrenal
T14629 5537-5552 NN denotes differentiation
T14630 5553-5554 -LRB- denotes [
T14631 5554-5556 CD denotes 55
T14632 5556-5557 -RRB- denotes ]
T14633 5559-5568 RB denotes Therefore
T14634 5568-5569 -COMMA- denotes ,
T14635 5570-5573 DT denotes the
T14636 5574-5578 NN denotes role
T14637 5579-5581 IN denotes of
T14638 5582-5587 NN denotes GATA3
T14639 5588-5595 VB denotes appears
T14640 5596-5598 TO denotes to
T14641 5599-5601 VB denotes be
T14642 5602-5608 NN denotes tissue
T14643 5609-5617 JJ denotes specific
T14644 5618-5621 CC denotes and
T14645 5622-5625 MD denotes can
T14646 5625-5628 RB denotes not
T14647 5629-5631 VB denotes be
T14648 5632-5643 VB denotes generalized
T14649 5645-5648 PRP-DOLLAR- denotes Our
T14650 5649-5654 NN denotes study
T14651 5655-5667 VB denotes demonstrates
T14652 5668-5672 IN denotes that
T14653 5673-5678 NN denotes GATA3
T14654 5679-5688 VB denotes repressed
T14655 5689-5694 NN denotes FOXP3
T14656 5695-5705 NN denotes expression
T14657 5706-5714 RB denotes directly
T14658 5715-5717 IN denotes by
T14659 5718-5725 VB denotes binding
T14660 5726-5728 TO denotes to
T14661 5729-5732 DT denotes the
T14662 5733-5738 NN denotes FOXP3
T14663 5739-5747 NN denotes promoter
T14664 5748-5754 NN denotes region
T14665 5756-5757 DT denotes A
T14666 5758-5769 JJ denotes palindromic
T14667 5770-5779 NN denotes GATA-site
T14668 5780-5782 VB denotes is
T14669 5783-5790 JJ denotes located
T14670 5791-5794 CD denotes 303
T14671 5795-5797 NN denotes bp
T14672 5798-5806 RB denotes upstream
T14673 5807-5809 IN denotes of
T14674 5810-5813 DT denotes the
T14675 5814-5817 NN denotes TSS
T14676 5818-5820 IN denotes in
T14677 5821-5822 DT denotes a
T14678 5823-5829 RB denotes highly
T14679 5830-5839 VB denotes conserved
T14680 5840-5846 NN denotes region
T14681 5846-5847 -COMMA- denotes ,
T14682 5848-5853 WDT denotes which
T14683 5854-5856 PRP denotes we
T14684 5857-5861 VB denotes have
T14685 5862-5872 RB denotes previously
T14686 5873-5883 VB denotes identified
T14687 5884-5886 IN denotes as
T14688 5887-5890 DT denotes the
T14689 5891-5896 NN denotes FOXP3
T14690 5897-5905 NN denotes promoter
T14691 5906-5907 -LRB- denotes [
T14692 5907-5909 CD denotes 24
T14693 5909-5910 -RRB- denotes ]
T14694 5912-5925 JJ denotes Site-specific
T14695 5926-5934 NN denotes mutation
T14696 5935-5937 IN denotes of
T14697 5938-5942 DT denotes this
T14698 5943-5947 NN denotes site
T14699 5948-5957 VB denotes increased
T14700 5958-5961 DT denotes the
T14701 5962-5970 NN denotes activity
T14702 5971-5973 IN denotes of
T14703 5974-5977 DT denotes the
T14704 5978-5986 NN denotes promoter
T14705 5987-5997 NN denotes constructs
T14706 5997-5998 -COMMA- denotes ,
T14707 5999-6003 RB denotes thus
T14708 6004-6013 VB denotes revealing
T14709 6014-6017 DT denotes the
T14710 6018-6028 JJ denotes repressive
T14711 6029-6035 NN denotes nature
T14712 6036-6038 IN denotes of
T14713 6039-6043 DT denotes this
T14714 6044-6048 NN denotes GATA
T14715 6049-6056 NN denotes element
T14716 6057-6059 IN denotes in
T14717 6060-6066 NN denotes memory
T14718 6067-6068 NN denotes T
T14719 6069-6074 NN denotes cells
T14720 6074-6075 -COMMA- denotes ,
T14721 6076-6081 WDT denotes which
T14722 6082-6091 RB denotes naturally
T14723 6092-6099 VB denotes express
T14724 6100-6105 NN denotes GATA3
T14725 6105-6106 -COMMA- denotes ,
T14726 6107-6114 IN denotes whereas
T14727 6115-6117 DT denotes no
T14728 6118-6128 NN denotes difference
T14729 6129-6132 VB denotes was
T14730 6133-6137 VB denotes seen
T14731 6138-6140 IN denotes in
T14732 6141-6146 JJ denotes naive
T14733 6147-6148 NN denotes T
T14734 6149-6154 NN denotes cells
T14735 6154-6155 -COMMA- denotes ,
T14736 6156-6161 WDT denotes which
T14737 6162-6164 VB denotes do
T14738 6165-6168 RB denotes not
T14739 6169-6176 VB denotes express
T14740 6177-6182 NN denotes GATA3
T14741 6184-6188 DT denotes This
T14742 6189-6200 JJ denotes palindromic
T14743 6201-6205 NN denotes GATA
T14744 6206-6213 NN denotes element
T14745 6214-6216 VB denotes is
T14746 6217-6222 VB denotes bound
T14747 6223-6225 IN denotes by
T14748 6226-6231 NN denotes GATA3
T14749 6232-6239 NN denotes protein
T14750 6240-6242 IN denotes as
T14751 6243-6249 VB denotes proven
T14752 6250-6254 IN denotes with
T14753 6255-6264 JJ denotes pull-down
T14754 6265-6276 NN denotes experiments
T14755 6278-6289 RB denotes Furthermore
T14756 6289-6290 -COMMA- denotes ,
T14757 6291-6293 PRP denotes it
T14758 6294-6296 VB denotes is
T14759 6297-6302 VB denotes shown
T14760 6303-6305 IN denotes by
T14761 6306-6310 NN denotes ChIP
T14762 6311-6315 IN denotes that
T14763 6316-6321 NN denotes GATA3
T14764 6322-6327 VB denotes binds
T14765 6328-6332 DT denotes this
T14766 6333-6340 NN denotes element
T14767 6341-6345 RB denotes also
T14768 6346-6348 IN denotes in
T14769 6349-6355 JJ denotes intact
T14770 6356-6361 NN denotes cells
T14771 6363-6365 PRP denotes It
T14772 6366-6368 VB denotes is
T14773 6369-6374 VB denotes known
T14774 6375-6379 IN denotes that
T14775 6380-6385 NN denotes GATA3
T14776 6386-6389 MD denotes can
T14777 6390-6396 VB denotes induce
T14778 6397-6410 NN denotes transcription
T14779 6411-6413 IN denotes by
T14780 6414-6423 NN denotes chromatin
T14781 6424-6434 VB denotes remodeling
T14782 6435-6436 -LRB- denotes [
T14783 6436-6438 CD denotes 56
T14784 6438-6439 -RRB- denotes ]
T14785 6439-6440 -COMMA- denotes ,
T14786 6441-6443 IN denotes by
T14787 6444-6452 RB denotes directly
T14788 6453-6468 VB denotes transactivating
T14789 6469-6478 NN denotes promoters
T14790 6479-6480 -LRB- denotes [
T14791 6480-6482 CD denotes 36
T14792 6482-6483 -RRB- denotes ]
T14793 6483-6484 -COMMA- denotes ,
T14794 6485-6487 CC denotes or
T14795 6487-6488 -COMMA- denotes ,
T14796 6489-6491 IN denotes as
T14797 6492-6497 VB denotes shown
T14798 6498-6500 IN denotes in
T14799 6501-6504 DT denotes the
T14800 6505-6512 JJ denotes current
T14801 6513-6518 NN denotes study
T14802 6518-6519 -COMMA- denotes ,
T14803 6520-6524 VB denotes acts
T14804 6525-6527 IN denotes as
T14805 6528-6529 DT denotes a
T14806 6530-6539 NN denotes repressor
T14807 6540-6542 IN denotes of
T14808 6543-6547 NN denotes gene
T14809 6548-6558 NN denotes expression
T14810 6559-6560 -LRB- denotes [
T14811 6560-6568 CD denotes 21,57–59
T14812 6568-6569 -RRB- denotes ]
T14813 6571-6580 RB denotes Therefore
T14814 6581-6588 VB denotes keeping
T14815 6589-6594 NN denotes GATA3
T14816 6595-6605 NN denotes expression
T14817 6606-6609 JJ denotes low
T14818 6610-6615 MD denotes might
T14819 6616-6618 VB denotes be
T14820 6619-6627 VB denotes required
T14821 6628-6630 TO denotes to
T14822 6631-6637 VB denotes induce
T14823 6638-6647 JJ denotes efficient
T14824 6648-6654 JJ denotes FOXP3+
T14825 6655-6660 NN denotes iTreg
T14826 6661-6665 NN denotes cell
T14827 6666-6676 NN denotes generation
T14828 6678-6681 DT denotes The
T14829 6682-6691 JJ denotes molecular
T14830 6692-6704 NN denotes interactions
T14831 6705-6713 VB denotes enabling
T14832 6714-6719 NN denotes GATA3
T14833 6720-6722 TO denotes to
T14834 6723-6730 VB denotes inhibit
T14835 6731-6736 NN denotes FOXP3
T14836 6737-6740 VB denotes are
T14837 6741-6744 RB denotes not
T14838 6745-6755 VB denotes identified
T14839 6756-6759 RB denotes yet
T14840 6759-6760 -COMMA- denotes ,
T14841 6761-6764 CC denotes but
T14842 6765-6768 DT denotes the
T14843 6769-6781 JJ denotes GATA-binding
T14844 6782-6786 NN denotes site
T14845 6787-6789 VB denotes is
T14846 6790-6797 VB denotes located
T14847 6798-6806 JJ denotes adjacent
T14848 6807-6809 TO denotes to
T14849 6810-6818 JJ denotes positive
T14850 6818-6819 -COMMA- denotes ,
T14851 6820-6828 VB denotes inducing
T14852 6829-6834 NN denotes sites
T14853 6834-6835 -COMMA- denotes ,
T14854 6836-6844 VB denotes composed
T14855 6845-6847 IN denotes of
T14856 6848-6859 NN denotes AP-1-NFATc2
T14857 6860-6865 NN denotes sites
T14858 6866-6867 -LRB- denotes [
T14859 6867-6869 CD denotes 24
T14860 6869-6870 -RRB- denotes ]
T14861 6870-6871 -COMMA- denotes ,
T14862 6872-6875 CC denotes and
T14863 6876-6881 NN denotes GATA3
T14864 6882-6885 MD denotes may
T14865 6886-6893 VB denotes compete
T14866 6894-6898 IN denotes with
T14867 6899-6902 DT denotes the
T14868 6903-6910 NN denotes binding
T14869 6911-6913 IN denotes of
T14870 6914-6923 NN denotes AP-1/NFAT
T14871 6924-6926 TO denotes to
T14872 6927-6930 DT denotes the
T14873 6931-6939 NN denotes promoter
T14874 6940-6941 -LRB- denotes (
T14875 6941-6952 JJ denotes unpublished
T14876 6953-6965 NN denotes observations
T14877 6965-6966 -RRB- denotes )
T14878 6968-6970 IN denotes In
T14879 6971-6978 NN denotes summary
T14880 6978-6979 -COMMA- denotes ,
T14881 6980-6982 PRP denotes we
T14882 6983-6995 VB denotes demonstrated
T14883 6996-7000 IN denotes that
T14884 7001-7006 NN denotes FOXP3
T14885 7007-7009 VB denotes is
T14886 7010-7020 RB denotes negatively
T14887 7021-7030 VB denotes regulated
T14888 7031-7033 IN denotes by
T14889 7034-7043 NN denotes cytokines
T14890 7044-7048 JJ denotes such
T14891 7049-7051 IN denotes as
T14892 7052-7056 NN denotes IL-4
T14893 7058-7063 NN denotes GATA3
T14894 7064-7068 VB denotes acts
T14895 7069-7071 IN denotes as
T14896 7072-7074 DT denotes an
T14897 7075-7084 NN denotes inhibitor
T14898 7085-7087 IN denotes of
T14899 7088-7093 NN denotes FOXP3
T14900 7094-7104 NN denotes expression
T14901 7105-7107 IN denotes in
T14902 7108-7113 JJ denotes early
T14903 7114-7115 NN denotes T
T14904 7116-7120 NN denotes cell
T14905 7121-7136 NN denotes differentiation
T14906 7136-7137 -COMMA- denotes ,
T14907 7138-7140 RB denotes as
T14908 7141-7145 RB denotes well
T14909 7146-7148 IN denotes as
T14910 7149-7151 IN denotes in
T14911 7152-7166 VB denotes differentiated
T14912 7167-7170 NN denotes Th2
T14913 7171-7176 NN denotes cells
T14914 7177-7179 IN denotes by
T14915 7180-7188 RB denotes directly
T14916 7189-7196 VB denotes binding
T14917 7197-7200 CC denotes and
T14918 7201-7211 VB denotes repressing
T14919 7212-7215 DT denotes the
T14920 7216-7221 NN denotes FOXP3
T14921 7222-7230 NN denotes promoter
T14922 7232-7234 PRP denotes We
T14923 7235-7244 RB denotes therefore
T14924 7245-7253 VB denotes describe
T14925 7254-7255 DT denotes a
T14926 7256-7259 JJ denotes new
T14927 7260-7269 NN denotes mechanism
T14928 7270-7272 IN denotes of
T14929 7273-7276 WRB denotes how
T14930 7277-7281 NN denotes Il-4
T14931 7282-7288 NN denotes avoids
T14932 7289-7298 NN denotes tolerance
T14933 7299-7308 NN denotes induction
T14934 7309-7311 IN denotes by
T14935 7312-7322 VB denotes repressing
T14936 7323-7328 NN denotes FOXP3
T14937 7329-7339 NN denotes expression
T14938 7341-7346 DT denotes These
T14939 7347-7355 NN denotes findings
T14940 7356-7360 MD denotes will
T14941 7361-7365 VB denotes give
T14942 7366-7369 JJ denotes new
T14943 7370-7382 NN denotes perspectives
T14944 7383-7389 IN denotes toward
T14945 7390-7403 VB denotes understanding
T14946 7404-7413 JJ denotes molecular
T14947 7414-7424 NN denotes mechanisms
T14948 7425-7427 IN denotes of
T14949 7428-7433 NN denotes iTreg
T14950 7434-7443 NN denotes induction
T14951 7444-7447 CC denotes and
T14952 7448-7452 RB denotes thus
T14953 7453-7461 NN denotes pathways
T14954 7462-7464 IN denotes of
T14955 7465-7475 JJ denotes peripheral
T14956 7476-7485 NN denotes tolerance
T14957 7486-7495 NN denotes induction
T14958 7495-7496 -COMMA- denotes ,
T14959 7497-7509 RB denotes particularly
T14960 7510-7512 IN denotes in
T14961 7513-7520 NN denotes allergy
T14962 7521-7524 CC denotes and
T14963 7525-7531 NN denotes asthma
R10080 T13706 T13704 arg1Of study,The
R10081 T13706 T13705 arg1Of study,current
R10082 T13706 T13707 arg1Of study,reveals
R10083 T13710 T13709 arg1Of induction,FOXP3
R10084 T13710 T13711 arg1Of induction,","
R10085 T13710 T13719 arg1Of induction,is
R10086 T13710 T13720 arg2Of induction,inhibited
R10087 T13714 T13711 arg2Of step,","
R10088 T13714 T13712 arg1Of step,an
R10089 T13714 T13713 arg1Of step,important
R10090 T13714 T13715 arg1Of step,in
R10091 T13717 T13715 arg2Of commitment,in
R10092 T13717 T13716 arg1Of commitment,iTreg
R10093 T13720 T13707 arg2Of inhibited,reveals
R10094 T13720 T13708 arg1Of inhibited,that
R10095 T13720 T13718 arg1Of inhibited,","
R10096 T13720 T13719 arg2Of inhibited,is
R10097 T13722 T13720 arg1Of GATA3,inhibited
R10098 T13722 T13721 arg2Of GATA3,by
R10099 T13722 T13723 arg1Of GATA3,","
R10100 T13722 T13724 arg1Of GATA3,which
R10101 T13722 T13725 arg1Of GATA3,is
R10102 T13728 T13725 arg2Of regulator,is
R10103 T13728 T13726 arg1Of regulator,the
R10104 T13728 T13727 arg1Of regulator,key
R10105 T13728 T13729 arg1Of regulator,for
R10106 T13730 T13729 arg2Of polarization,for
R10107 T13730 T13731 arg1Of polarization,toward
R10108 T13733 T13731 arg2Of cells,toward
R10109 T13733 T13732 arg1Of cells,Th2
R10110 T13735 T13734 arg2Of differentiation,After
R10111 T13740 T13737 arg1Of cells,the
R10112 T13740 T13738 arg1Of cells,effector
R10113 T13740 T13739 arg1Of cells,Th2
R10114 T13740 T13741 arg1Of cells,become
R10115 T13740 T13742 arg1Of cells,refractory
R10116 T13741 T13734 arg1Of become,After
R10117 T13741 T13736 arg1Of become,","
R10118 T13742 T13741 arg2Of refractory,become
R10119 T13742 T13743 arg1Of refractory,to
R10120 T13744 T13743 arg2Of conversion,to
R10121 T13744 T13745 arg1Of conversion,into
R10122 T13748 T13745 arg2Of phenotype,into
R10123 T13748 T13746 arg1Of phenotype,a
R10124 T13748 T13747 arg1Of phenotype,FOXP3+
R10125 T13750 T13749 arg2Of accordance,In
R10126 T13750 T13751 arg1Of accordance,with
R10127 T13753 T13751 arg2Of studies,with
R10128 T13753 T13752 arg1Of studies,other
R10129 T13755 T13756 arg1Of we,found
R10130 T13756 T13749 arg1Of found,In
R10131 T13756 T13754 arg1Of found,","
R10132 T13759 T13758 arg1Of cells,CD4+CD25–
R10133 T13759 T13760 arg1Of cells,were
R10134 T13759 T13761 arg1Of cells,able
R10135 T13759 T13763 arg1Of cells,up-regulate
R10136 T13760 T13756 arg2Of were,found
R10137 T13760 T13757 arg1Of were,that
R10138 T13761 T13760 arg2Of able,were
R10139 T13763 T13761 arg2Of up-regulate,able
R10140 T13763 T13762 arg1Of up-regulate,to
R10141 T13763 T13765 arg1Of up-regulate,[
R10142 T13764 T13763 arg2Of FOXP3,up-regulate
R10143 T13766 T13765 arg2Of "12,27",[
R10144 T13767 T13765 arg3Of ],[
R10145 T13769 T13768 arg1Of cells,Already-committed
R10146 T13769 T13771 arg1Of cells,as
R10147 T13769 T13778 arg1Of cells,showed
R10148 T13771 T13770 arg1Of as,such
R10149 T13774 T13772 arg1Of cells,memory
R10150 T13774 T13773 arg1Of cells,T
R10151 T13774 T13775 arg1Of cells,and
R10152 T13775 T13771 arg2Of and,as
R10153 T13777 T13775 arg2Of cells,and
R10154 T13777 T13776 arg1Of cells,Th1
R10155 T13780 T13781 arg1Of moderate,and
R10156 T13781 T13779 arg1Of and,only
R10157 T13782 T13781 arg2Of transient,and
R10158 T13784 T13778 arg2Of induction,showed
R10159 T13784 T13780 arg1Of induction,moderate
R10160 T13784 T13782 arg1Of induction,transient
R10161 T13784 T13783 arg1Of induction,FOXP3
R10162 T13784 T13785 arg1Of induction,","
R10163 T13784 T13786 arg1Of induction,which
R10164 T13784 T13787 arg1Of induction,is
R10165 T13784 T13789 arg1Of induction,sufficient
R10166 T13784 T13791 arg1Of induction,change
R10167 T13787 T13788 arg1Of is,not
R10168 T13789 T13787 arg2Of sufficient,is
R10169 T13791 T13789 arg2Of change,sufficient
R10170 T13791 T13790 arg1Of change,to
R10171 T13791 T13794 arg1Of change,toward
R10172 T13793 T13791 arg2Of phenotype,change
R10173 T13793 T13792 arg1Of phenotype,the
R10174 T13799 T13794 arg2Of profile,toward
R10175 T13799 T13795 arg1Of profile,a
R10176 T13799 T13796 arg1Of profile,regulatory
R10177 T13799 T13797 arg1Of profile,T
R10178 T13799 T13798 arg1Of profile,cell
R10179 T13801 T13800 arg2Of contrast,In
R10180 T13805 T13803 arg1Of cells,naive
R10181 T13805 T13804 arg1Of cells,T
R10182 T13805 T13806 arg1Of cells,could
R10183 T13805 T13808 arg1Of cells,up-regulate
R10184 T13808 T13800 arg1Of up-regulate,In
R10185 T13808 T13802 arg1Of up-regulate,","
R10186 T13808 T13806 arg2Of up-regulate,could
R10187 T13808 T13807 arg1Of up-regulate,efficiently
R10188 T13808 T13810 arg1Of up-regulate,when
R10189 T13808 T13821 arg1Of up-regulate,","
R10190 T13808 T13822 modOf up-regulate,suggesting
R10191 T13809 T13808 arg2Of FOXP3,up-regulate
R10192 T13811 T13810 arg2Of treated,when
R10193 T13811 T13812 arg1Of treated,with
R10194 T13811 T13814 modOf treated,to
R10195 T13813 T13812 arg2Of TGF-β,with
R10196 T13815 T13814 arg1Of induce,to
R10197 T13817 T13815 arg2Of cells,induce
R10198 T13817 T13816 arg1Of cells,iTreg
R10199 T13817 T13818 arg1Of cells,[
R10200 T13819 T13818 arg2Of "10,28–34",[
R10201 T13820 T13818 arg3Of ],[
R10202 T13824 T13825 arg1Of FOXP3,plays
R10203 T13824 T13835 arg1Of FOXP3,may
R10204 T13824 T13836 arg1Of FOXP3,act
R10205 T13825 T13829 arg1Of plays,in
R10206 T13825 T13834 arg1Of plays,and
R10207 T13828 T13825 arg2Of role,plays
R10208 T13828 T13826 arg1Of role,an
R10209 T13828 T13827 arg1Of role,important
R10210 T13833 T13829 arg2Of process,in
R10211 T13833 T13830 arg1Of process,the
R10212 T13833 T13831 arg1Of process,early
R10213 T13833 T13832 arg1Of process,differentiation
R10214 T13834 T13822 arg2Of and,suggesting
R10215 T13834 T13823 arg1Of and,that
R10216 T13836 T13834 arg2Of act,and
R10217 T13836 T13835 arg2Of act,may
R10218 T13836 T13837 arg1Of act,in
R10219 T13839 T13837 arg2Of way,in
R10220 T13839 T13838 arg1Of way,a
R10221 T13839 T13840 arg1Of way,similar
R10222 T13840 T13841 arg1Of similar,to
R10223 T13842 T13841 arg2Of that,to
R10224 T13842 T13843 arg2Of that,known
R10225 T13843 T13844 arg1Of known,for
R10226 T13849 T13850 arg1Of T-bet,and
R10227 T13850 T13844 arg2Of and,for
R10228 T13850 T13845 arg1Of and,the
R10229 T13850 T13846 arg1Of and,Th1/Th2
R10230 T13850 T13847 arg1Of and,decision
R10231 T13850 T13848 arg1Of and,factors
R10232 T13851 T13850 arg2Of GATA3,and
R10233 T13853 T13852 arg1Of commitment,This
R10234 T13853 T13854 arg1Of commitment,is
R10235 T13853 T13855 arg2Of commitment,characterized
R10236 T13855 T13854 arg2Of characterized,is
R10237 T13855 T13865 arg1Of characterized,","
R10238 T13858 T13855 arg1Of expression,characterized
R10239 T13858 T13856 arg2Of expression,by
R10240 T13858 T13857 arg1Of expression,competitive
R10241 T13858 T13859 arg1Of expression,of
R10242 T13858 T13862 arg1Of expression,[
R10243 T13861 T13859 arg2Of factors,of
R10244 T13861 T13860 arg1Of factors,these
R10245 T13863 T13862 arg2Of "35,36",[
R10246 T13864 T13862 arg3Of ],[
R10247 T13866 T13869 arg2Of which,observed
R10248 T13867 T13869 arg1Of we,observed
R10249 T13869 T13854 modOf observed,is
R10250 T13869 T13868 arg1Of observed,also
R10251 T13869 T13870 arg1Of observed,in
R10252 T13874 T13870 arg2Of cells,in
R10253 T13874 T13871 arg1Of cells,differentiating
R10254 T13874 T13872 arg1Of cells,FOXP3+
R10255 T13874 T13873 arg1Of cells,iTreg
R10256 T13874 T13875 arg1Of cells,including
R10257 T13877 T13875 arg2Of phase,including
R10258 T13877 T13876 arg1Of phase,a
R10259 T13877 T13878 arg1Of phase,of
R10260 T13877 T13880 arg1Of phase,","
R10261 T13877 T13881 arg1Of phase,which
R10262 T13877 T13882 arg1Of phase,turns
R10263 T13879 T13878 arg2Of co-expression,of
R10264 T13882 T13883 arg1Of turns,into
R10265 T13882 T13886 arg1Of turns,upon
R10266 T13885 T13883 arg2Of expression,into
R10267 T13885 T13884 arg1Of expression,nonoverlapping
R10268 T13888 T13886 arg2Of differentiation,upon
R10269 T13888 T13887 arg2Of differentiation,completed
R10270 T13892 T13889 arg2Of process,In
R10271 T13892 T13890 arg1Of process,this
R10272 T13892 T13891 arg1Of process,competitive
R10273 T13893 T13894 arg1Of TGF-β,appeared
R10274 T13893 T13896 arg1Of TGF-β,be
R10275 T13893 T13897 arg1Of TGF-β,mandatory
R10276 T13893 T13906 arg1Of TGF-β,keeping
R10277 T13894 T13889 arg1Of appeared,In
R10278 T13896 T13894 arg2Of be,appeared
R10279 T13896 T13895 arg1Of be,to
R10280 T13896 T13903 arg1Of be,","
R10281 T13896 T13905 arg1Of be,by
R10282 T13897 T13896 arg2Of mandatory,be
R10283 T13897 T13898 arg1Of mandatory,for
R10284 T13900 T13898 arg2Of induction,for
R10285 T13900 T13899 arg1Of induction,the
R10286 T13900 T13901 arg1Of induction,of
R10287 T13902 T13901 arg2Of FOXP3,of
R10288 T13905 T13904 arg1Of by,possibly
R10289 T13906 T13905 arg2Of keeping,by
R10290 T13908 T13906 arg2Of expression,keeping
R10291 T13908 T13907 arg1Of expression,the
R10292 T13908 T13909 arg1Of expression,of
R10293 T13910 T13911 arg1Of GATA3,and
R10294 T13912 T13911 arg2Of T-bet,and
R10295 T13913 T13909 arg2Of low,of
R10296 T13913 T13910 arg1Of low,GATA3
R10297 T13913 T13912 arg1Of low,T-bet
R10298 T13913 T13914 arg1Of low,[
R10299 T13915 T13914 arg2Of "37,38",[
R10300 T13916 T13914 arg3Of ],[
R10301 T13918 T13917 arg2Of contrast,In
R10302 T13923 T13920 arg1Of cells,differentiating
R10303 T13923 T13921 arg1Of cells,naive
R10304 T13923 T13922 arg1Of cells,T
R10305 T13923 T13924 arg1Of cells,in
R10306 T13923 T13941 arg1Of cells,showed
R10307 T13923 T13948 arg1Of cells,failed
R10308 T13923 T13950 arg1Of cells,generate
R10309 T13926 T13924 arg2Of absence,in
R10310 T13926 T13925 arg1Of absence,the
R10311 T13926 T13927 arg1Of absence,of
R10312 T13929 T13927 arg2Of factors,of
R10313 T13929 T13928 arg1Of factors,polarization
R10314 T13929 T13930 arg1Of factors,(
R10315 T13929 T13934 arg1Of factors,as
R10316 T13931 T13930 arg2Of Th0,(
R10317 T13932 T13930 arg3Of ),(
R10318 T13934 T13933 arg1Of as,such
R10319 T13935 T13936 arg1Of IL-4,","
R10320 T13936 T13939 arg1Of ",",or
R10321 T13937 T13936 arg2Of IL-12,","
R10322 T13939 T13934 arg2Of or,as
R10323 T13939 T13938 arg1Of or,","
R10324 T13940 T13939 arg2Of TGF-β,or
R10325 T13941 T13947 arg1Of showed,and
R10326 T13946 T13941 arg2Of expression,showed
R10327 T13946 T13942 arg1Of expression,only
R10328 T13946 T13943 arg1Of expression,a
R10329 T13946 T13944 arg1Of expression,transient
R10330 T13946 T13945 arg1Of expression,FOXP3
R10331 T13947 T13957 arg1Of and,but
R10332 T13948 T13947 arg2Of failed,and
R10333 T13950 T13948 arg2Of generate,failed
R10334 T13950 T13949 arg1Of generate,to
R10335 T13952 T13950 arg2Of population,generate
R10336 T13952 T13951 arg1Of population,a
R10337 T13952 T13953 arg1Of population,of
R10338 T13955 T13953 arg2Of cells,of
R10339 T13955 T13954 arg1Of cells,FOXP3-expressing
R10340 T13957 T13917 arg1Of but,In
R10341 T13957 T13919 arg1Of but,","
R10342 T13957 T13956 arg1Of but,","
R10343 T13958 T13959 arg1Of GATA3,and
R10344 T13959 T13961 arg1Of and,were
R10345 T13959 T13962 arg2Of and,up-regulated
R10346 T13960 T13959 arg2Of T-bet,and
R10347 T13962 T13957 arg2Of up-regulated,but
R10348 T13962 T13961 arg2Of up-regulated,were
R10349 T13962 T13963 arg1Of up-regulated,(
R10350 T13965 T13963 arg2Of data,(
R10351 T13965 T13964 arg1Of data,unpublished
R10352 T13966 T13963 arg3Of ),(
R10353 T13967 T13968 arg1Of Interestingly,","
R10354 T13969 T13968 arg2Of as,","
R10355 T13972 T13969 arg2Of others,as
R10356 T13972 T13970 arg1Of others,we
R10357 T13972 T13971 arg1Of others,and
R10358 T13972 T13973 arg1Of others,previously
R10359 T13974 T13975 arg1Of described,","
R10360 T13976 T13975 arg2Of FOXP3-promoting,","
R10361 T13977 T13974 arg1Of factors,described
R10362 T13977 T13976 arg1Of factors,FOXP3-promoting
R10363 T13977 T13978 arg1Of factors,","
R10364 T13977 T13980 arg1Of factors,as
R10365 T13977 T13991 arg1Of factors,and
R10366 T13980 T13979 arg1Of as,such
R10367 T13981 T13982 arg1Of dexamethasone,[
R10368 T13981 T13985 arg1Of dexamethasone,","
R10369 T13983 T13982 arg2Of 39,[
R10370 T13984 T13982 arg3Of ],[
R10371 T13985 T13980 arg2Of ",",as
R10372 T13986 T13985 arg2Of CTLA-4,","
R10373 T13986 T13987 arg1Of CTLA-4,[
R10374 T13988 T13987 arg2Of 40,[
R10375 T13989 T13987 arg3Of ],[
R10376 T13991 T13990 arg1Of and,","
R10377 T13991 T13997 arg1Of and,are
R10378 T13991 T13999 arg2Of and,known
R10379 T13992 T13991 arg2Of estrogens,and
R10380 T13992 T13993 arg1Of estrogens,[
R10381 T13994 T13993 arg2Of 41,[
R10382 T13995 T13993 arg3Of ],[
R10383 T13999 T13967 arg1Of known,Interestingly
R10384 T13999 T13969 arg1Of known,as
R10385 T13999 T13996 arg1Of known,","
R10386 T13999 T13997 arg2Of known,are
R10387 T13999 T13998 arg1Of known,also
R10388 T13999 T14000 arg1Of known,as
R10389 T14001 T14000 arg2Of inhibitors,as
R10390 T14001 T14002 arg1Of inhibitors,of
R10391 T14004 T14002 arg2Of expression,of
R10392 T14004 T14003 arg1Of expression,GATA3
R10393 T14004 T14005 arg1Of expression,[
R10394 T14006 T14005 arg2Of 42–45,[
R10395 T14007 T14005 arg3Of ],[
R10396 T14009 T14012 arg1Of GATA3,induces
R10397 T14009 T14019 arg1Of GATA3,inhibits
R10398 T14011 T14010 arg1Of only,not
R10399 T14012 T14014 arg1Of induces,into
R10400 T14012 T14017 arg1Of induces,but
R10401 T14013 T14012 arg2Of differentiation,induces
R10402 T14016 T14014 arg2Of cells,into
R10403 T14016 T14015 arg1Of cells,Th2
R10404 T14017 T14008 arg1Of but,Therefore
R10405 T14017 T14011 arg1Of but,only
R10406 T14017 T14018 arg1Of but,also
R10407 T14019 T14017 arg2Of inhibits,but
R10408 T14021 T14022 arg1Of expression,and
R10409 T14022 T14019 arg2Of and,inhibits
R10410 T14022 T14020 arg1Of and,FOXP3
R10411 T14022 T14024 arg1Of and,into
R10412 T14023 T14022 arg2Of commitment,and
R10413 T14026 T14024 arg2Of cells,into
R10414 T14026 T14025 arg1Of cells,iTreg
R10415 T14029 T14027 arg1Of cytokine,The
R10416 T14029 T14028 arg1Of cytokine,Th2
R10417 T14030 T14029 arg1Of IL-4,cytokine
R10418 T14030 T14031 arg1Of IL-4,but
R10419 T14031 T14038 arg1Of but,was
R10420 T14031 T14039 arg1Of but,able
R10421 T14031 T14041 arg1Of but,inhibit
R10422 T14031 T14047 arg1Of but,prevented
R10423 T14033 T14031 arg2Of IL-13,but
R10424 T14033 T14032 arg1Of IL-13,not
R10425 T14033 T14034 arg1Of IL-13,(
R10426 T14036 T14034 arg2Of data,(
R10427 T14036 T14035 arg1Of data,unpublished
R10428 T14037 T14034 arg3Of ),(
R10429 T14038 T14045 arg1Of was,and
R10430 T14039 T14038 arg2Of able,was
R10431 T14041 T14039 arg2Of inhibit,able
R10432 T14041 T14040 arg1Of inhibit,to
R10433 T14044 T14041 arg2Of induction,inhibit
R10434 T14044 T14042 arg1Of induction,TGF-β–mediated
R10435 T14044 T14043 arg1Of induction,FOXP3
R10436 T14047 T14045 arg2Of prevented,and
R10437 T14047 T14046 arg1Of prevented,therefore
R10438 T14048 T14047 arg2Of conversion,prevented
R10439 T14048 T14049 arg1Of conversion,into
R10440 T14052 T14049 arg2Of phenotype,into
R10441 T14052 T14050 arg1Of phenotype,the
R10442 T14052 T14051 arg1Of phenotype,regulatory
R10443 T14054 T14053 arg1Of prove,To
R10444 T14054 T14067 arg1Of prove,vivo
R10445 T14057 T14054 arg2Of effect,prove
R10446 T14057 T14055 arg1Of effect,the
R10447 T14057 T14056 arg1Of effect,inhibitory
R10448 T14057 T14058 arg1Of effect,of
R10449 T14057 T14060 arg1Of effect,on
R10450 T14059 T14058 arg2Of IL-4,of
R10451 T14061 T14062 arg1Of inducible,or
R10452 T14063 T14062 arg2Of natural,or
R10453 T14065 T14060 arg2Of commitment,on
R10454 T14065 T14061 arg1Of commitment,inducible
R10455 T14065 T14063 arg1Of commitment,natural
R10456 T14065 T14064 arg1Of commitment,Treg
R10457 T14067 T14066 arg1Of vivo,in
R10458 T14069 T14054 arg1Of we,prove
R10459 T14069 T14070 arg1Of we,treated
R10460 T14070 T14053 modOf treated,To
R10461 T14070 T14068 arg1Of treated,","
R10462 T14071 T14070 arg2Of mice,treated
R10463 T14071 T14072 arg1Of mice,with
R10464 T14073 T14074 arg1Of IL-4,and
R10465 T14074 T14072 arg2Of and,with
R10466 T14075 T14074 arg2Of anti-IL-4,and
R10467 T14076 T14077 arg1Of This,has
R10468 T14076 T14078 arg1Of This,been
R10469 T14076 T14079 arg2Of This,shown
R10470 T14076 T14081 arg1Of This,increase
R10471 T14079 T14077 arg2Of shown,has
R10472 T14079 T14078 arg2Of shown,been
R10473 T14081 T14079 arg3Of increase,shown
R10474 T14081 T14080 arg1Of increase,to
R10475 T14081 T14089 arg1Of increase,[
R10476 T14083 T14081 arg2Of effect,increase
R10477 T14083 T14082 arg1Of effect,the
R10478 T14083 T14084 arg1Of effect,of
R10479 T14083 T14088 arg1Of effect,vivo
R10480 T14086 T14084 arg2Of cytokine,of
R10481 T14086 T14085 arg1Of cytokine,the
R10482 T14088 T14087 arg1Of vivo,in
R10483 T14090 T14089 arg2Of 19,[
R10484 T14091 T14089 arg3Of ],[
R10485 T14096 T14092 arg1Of complex,Only
R10486 T14096 T14093 arg1Of complex,the
R10487 T14096 T14094 arg1Of complex,IL-4/IL-4
R10488 T14096 T14095 arg1Of complex,mAb
R10489 T14096 T14097 arg1Of complex,resulted
R10490 T14097 T14098 arg1Of resulted,in
R10491 T14100 T14098 arg2Of decrease,in
R10492 T14100 T14099 arg1Of decrease,a
R10493 T14100 T14101 arg1Of decrease,of
R10494 T14103 T14102 arg1Of amount,the
R10495 T14103 T14104 arg1Of amount,of
R10496 T14103 T14111 arg1Of amount,and
R10497 T14105 T14106 arg1Of natural,or
R10498 T14107 T14106 arg2Of inducible,or
R10499 T14108 T14105 arg1Of Treg,natural
R10500 T14108 T14107 arg1Of Treg,inducible
R10501 T14108 T14109 arg1Of Treg,(
R10502 T14110 T14104 arg2Of CD25+,of
R10503 T14110 T14108 arg1Of CD25+,Treg
R10504 T14111 T14101 arg2Of and,of
R10505 T14116 T14111 arg2Of d,and
R10506 T14116 T14112 arg1Of d,Foxp3+
R10507 T14116 T14113 arg1Of d,)
R10508 T14116 T14114 arg1Of d,cells
R10509 T14116 T14115 arg1Of d,7
R10510 T14116 T14117 arg1Of d,after
R10511 T14118 T14117 arg2Of treatment,after
R10512 T14120 T14119 arg1Of results,Our
R10513 T14120 T14121 arg1Of results,suggest
R10514 T14123 T14124 arg1Of IL-4,is
R10515 T14123 T14126 arg1Of IL-4,interfering
R10516 T14126 T14121 arg2Of interfering,suggest
R10517 T14126 T14122 arg1Of interfering,that
R10518 T14126 T14124 arg2Of interfering,is
R10519 T14126 T14125 arg1Of interfering,only
R10520 T14126 T14127 arg1Of interfering,with
R10521 T14129 T14127 arg2Of differentiation,with
R10522 T14129 T14128 arg1Of differentiation,the
R10523 T14129 T14130 arg1Of differentiation,of
R10524 T14129 T14134 arg1Of differentiation,into
R10525 T14133 T14130 arg2Of cells,of
R10526 T14133 T14131 arg1Of cells,naive
R10527 T14133 T14132 arg1Of cells,T
R10528 T14136 T14134 arg2Of cells,into
R10529 T14136 T14135 arg1Of cells,iTreg
R10530 T14140 T14139 arg1Of distinction,a
R10531 T14140 T14141 arg1Of distinction,of
R10532 T14140 T14146 arg1Of distinction,is
R10533 T14140 T14149 arg1Of distinction,possible
R10534 T14142 T14143 arg1Of nTreg,and
R10535 T14144 T14143 arg2Of iTreg,and
R10536 T14145 T14141 arg2Of cells,of
R10537 T14145 T14142 arg1Of cells,nTreg
R10538 T14145 T14144 arg1Of cells,iTreg
R10539 T14146 T14138 arg2Of is,since
R10540 T14146 T14147 arg1Of is,currently
R10541 T14146 T14148 arg1Of is,not
R10542 T14146 T14150 arg1Of is,","
R10543 T14146 T14151 arg1Of is,because
R10544 T14149 T14146 arg2Of possible,is
R10545 T14153 T14152 arg1Of cells,iTreg
R10546 T14153 T14156 arg1Of cells,express
R10547 T14156 T14151 arg2Of express,because
R10548 T14156 T14154 arg1Of express,also
R10549 T14156 T14155 arg1Of express,transiently
R10550 T14156 T14158 arg1Of express,after
R10551 T14157 T14156 arg2Of CD25,express
R10552 T14159 T14158 arg2Of activation,after
R10553 T14159 T14164 arg2Of activation,exclude
R10554 T14161 T14162 arg1Of we,can
R10555 T14161 T14164 arg1Of we,exclude
R10556 T14164 T14160 arg1Of exclude,","
R10557 T14164 T14162 arg2Of exclude,can
R10558 T14164 T14163 arg1Of exclude,not
R10559 T14166 T14167 arg1Of IL-4,may
R10560 T14166 T14169 arg1Of IL-4,inhibit
R10561 T14169 T14165 arg1Of inhibit,that
R10562 T14169 T14167 arg2Of inhibit,may
R10563 T14169 T14168 arg1Of inhibit,also
R10564 T14169 T14176 arg1Of inhibit,vivo
R10565 T14169 T14177 arg1Of inhibit,or
R10566 T14171 T14169 arg2Of expression,inhibit
R10567 T14171 T14170 arg1Of expression,Foxp3
R10568 T14171 T14172 arg1Of expression,in
R10569 T14174 T14172 arg2Of cells,in
R10570 T14174 T14173 arg1Of cells,nTreg
R10571 T14176 T14175 arg1Of vivo,in
R10572 T14177 T14181 arg1Of or,may
R10573 T14177 T14182 arg1Of or,contribute
R10574 T14178 T14177 arg2Of that,or
R10575 T14180 T14178 arg2Of effects,that
R10576 T14180 T14179 arg1Of effects,additional
R10577 T14182 T14137 arg1Of contribute,But
R10578 T14182 T14138 arg1Of contribute,since
R10579 T14182 T14181 arg2Of contribute,may
R10580 T14182 T14183 arg1Of contribute,to
R10581 T14182 T14187 arg1Of contribute,in
R10582 T14186 T14183 arg2Of drop,to
R10583 T14186 T14184 arg1Of drop,the
R10584 T14186 T14185 arg2Of drop,observed
R10585 T14189 T14187 arg2Of expression,in
R10586 T14189 T14188 arg1Of expression,Foxp3
R10587 T14190 T14191 arg1Of IL-4,has
R10588 T14190 T14193 arg1Of IL-4,been
R10589 T14190 T14194 arg2Of IL-4,shown
R10590 T14190 T14197 arg1Of IL-4,regulate
R10591 T14194 T14191 arg2Of shown,has
R10592 T14194 T14192 arg1Of shown,already
R10593 T14194 T14193 arg2Of shown,been
R10594 T14197 T14194 arg3Of regulate,shown
R10595 T14197 T14195 arg1Of regulate,to
R10596 T14197 T14196 arg1Of regulate,negatively
R10597 T14197 T14214 arg1Of regulate,[
R10598 T14199 T14198 arg1Of development,the
R10599 T14199 T14200 arg1Of development,of
R10600 T14199 T14204 arg1Of development,into
R10601 T14199 T14206 arg1Of development,or
R10602 T14203 T14200 arg2Of cells,of
R10603 T14203 T14201 arg1Of cells,naive
R10604 T14203 T14202 arg1Of cells,T
R10605 T14205 T14204 arg2Of Th1,into
R10606 T14206 T14197 arg2Of or,regulate
R10607 T14210 T14206 arg2Of cells,or
R10608 T14210 T14207 arg1Of cells,the
R10609 T14210 T14208 arg1Of cells,IL-17–producing
R10610 T14210 T14209 arg1Of cells,T
R10611 T14210 T14211 arg1Of cells,(
R10612 T14212 T14211 arg2Of Th17,(
R10613 T14213 T14211 arg3Of ),(
R10614 T14215 T14214 arg2Of "46,47",[
R10615 T14216 T14214 arg3Of ],[
R10616 T14218 T14217 arg1Of effects,Similar
R10617 T14218 T14219 arg1Of effects,have
R10618 T14218 T14220 arg1Of effects,been
R10619 T14218 T14222 arg2Of effects,described
R10620 T14222 T14219 arg2Of described,have
R10621 T14222 T14220 arg2Of described,been
R10622 T14222 T14221 arg1Of described,recently
R10623 T14222 T14223 arg1Of described,for
R10624 T14224 T14223 arg2Of IL-6,for
R10625 T14224 T14225 arg1Of IL-6,","
R10626 T14224 T14226 arg1Of IL-6,which
R10627 T14224 T14228 arg2Of IL-6,combined
R10628 T14224 T14232 arg1Of IL-6,inhibits
R10629 T14224 T14239 arg1Of IL-6,induces
R10630 T14228 T14229 arg1Of combined,with
R10631 T14230 T14229 arg2Of TGF-β,with
R10632 T14232 T14238 arg1Of inhibits,and
R10633 T14234 T14232 arg2Of generation,inhibits
R10634 T14234 T14233 arg1Of generation,the
R10635 T14234 T14235 arg1Of generation,of
R10636 T14237 T14235 arg2Of cells,of
R10637 T14237 T14236 arg1Of cells,iTreg
R10638 T14238 T14227 arg1Of and,","
R10639 T14238 T14228 modOf and,combined
R10640 T14238 T14231 arg1Of and,","
R10641 T14239 T14238 arg2Of induces,and
R10642 T14239 T14245 arg1Of induces,by
R10643 T14240 T14239 arg2Of differentiation,induces
R10644 T14240 T14241 arg1Of differentiation,into
R10645 T14244 T14241 arg2Of cells,into
R10646 T14244 T14242 arg1Of cells,the
R10647 T14244 T14243 arg1Of cells,Th17
R10648 T14248 T14245 arg2Of mechanism,by
R10649 T14248 T14246 arg1Of mechanism,an
R10650 T14248 T14247 arg1Of mechanism,unknown
R10651 T14248 T14249 arg1Of mechanism,[
R10652 T14250 T14249 arg2Of "48,49",[
R10653 T14251 T14249 arg3Of ],[
R10654 T14254 T14253 arg1Of polarization,the
R10655 T14254 T14255 arg1Of polarization,into
R10656 T14254 T14258 arg1Of polarization,is
R10657 T14254 T14260 arg2Of polarization,regulated
R10658 T14257 T14255 arg2Of cells,into
R10659 T14257 T14256 arg1Of cells,iTreg
R10660 T14260 T14252 arg1Of regulated,Thus
R10661 T14260 T14258 arg2Of regulated,is
R10662 T14260 T14259 arg1Of regulated,negatively
R10663 T14264 T14262 arg1Of cytokines,the
R10664 T14264 T14263 arg1Of cytokines,effector
R10665 T14265 T14266 arg1Of IL-4,and
R10666 T14266 T14260 arg1Of and,regulated
R10667 T14266 T14261 arg2Of and,by
R10668 T14266 T14264 arg1Of and,cytokines
R10669 T14267 T14266 arg2Of IL-6,and
R10670 T14268 T14269 arg1Of IL-4,has
R10671 T14268 T14270 arg1Of IL-4,been
R10672 T14268 T14272 arg2Of IL-4,shown
R10673 T14268 T14274 arg1Of IL-4,induce
R10674 T14272 T14269 arg2Of shown,has
R10675 T14272 T14270 arg2Of shown,been
R10676 T14272 T14271 arg1Of shown,previously
R10677 T14274 T14272 arg3Of induce,shown
R10678 T14274 T14273 arg1Of induce,to
R10679 T14274 T14282 arg1Of induce,of
R10680 T14274 T14284 arg1Of induce,[
R10681 T14276 T14274 arg2Of generation,induce
R10682 T14276 T14275 arg1Of generation,the
R10683 T14276 T14277 arg1Of generation,of
R10684 T14280 T14277 arg2Of cells,of
R10685 T14280 T14278 arg1Of cells,FOXP3+
R10686 T14280 T14279 arg1Of cells,Treg
R10687 T14282 T14281 arg1Of of,out
R10688 T14283 T14282 arg2Of CD4+CD25–,of
R10689 T14285 T14284 arg2Of 50,[
R10690 T14286 T14284 arg3Of ],[
R10691 T14289 T14287 arg2Of experiments,In
R10692 T14289 T14288 arg1Of experiments,those
R10693 T14292 T14291 arg1Of concentrations,the
R10694 T14292 T14293 arg1Of concentrations,of
R10695 T14292 T14296 arg1Of concentrations,were
R10696 T14292 T14297 arg1Of concentrations,low
R10697 T14292 T14310 arg1Of concentrations,enhanced
R10698 T14294 T14293 arg2Of IL-4,of
R10699 T14294 T14295 arg2Of IL-4,used
R10700 T14296 T14299 arg1Of were,and
R10701 T14297 T14296 arg2Of low,were
R10702 T14299 T14287 arg1Of and,In
R10703 T14299 T14290 arg1Of and,","
R10704 T14299 T14298 arg1Of and,","
R10705 T14301 T14303 arg1Of we,observed
R10706 T14303 T14300 arg2Of observed,as
R10707 T14303 T14302 arg1Of observed,also
R10708 T14303 T14304 arg1Of observed,","
R10709 T14305 T14303 arg2Of IL-4,observed
R10710 T14305 T14306 arg1Of IL-4,at
R10711 T14308 T14306 arg2Of concentration,at
R10712 T14308 T14307 arg1Of concentration,low
R10713 T14310 T14299 arg2Of enhanced,and
R10714 T14310 T14300 arg1Of enhanced,as
R10715 T14310 T14309 arg1Of enhanced,slightly
R10716 T14312 T14310 arg2Of expression,enhanced
R10717 T14312 T14311 arg1Of expression,FOXP3
R10718 T14316 T14315 arg1Of concentrations,these
R10719 T14316 T14317 arg1Of concentrations,were
R10720 T14316 T14319 arg1Of concentrations,sufficient
R10721 T14317 T14313 arg1Of were,Importantly
R10722 T14317 T14314 arg1Of were,","
R10723 T14317 T14318 arg1Of were,not
R10724 T14319 T14317 arg2Of sufficient,were
R10725 T14321 T14319 arg2Of induce,sufficient
R10726 T14321 T14320 arg1Of induce,to
R10727 T14323 T14321 arg2Of expression,induce
R10728 T14323 T14322 arg1Of expression,GATA3
R10729 T14324 T14325 arg1Of IL-4,may
R10730 T14324 T14326 arg1Of IL-4,favor
R10731 T14324 T14336 arg1Of IL-4,regulate
R10732 T14326 T14334 arg1Of favor,or
R10733 T14327 T14326 arg2Of proliferation,favor
R10734 T14327 T14328 arg1Of proliferation,of
R10735 T14327 T14331 arg1Of proliferation,[
R10736 T14330 T14328 arg2Of cells,of
R10737 T14330 T14329 arg1Of cells,nTreg
R10738 T14332 T14331 arg2Of 47,[
R10739 T14333 T14331 arg3Of ],[
R10740 T14334 T14325 arg2Of or,may
R10741 T14336 T14334 arg2Of regulate,or
R10742 T14336 T14335 arg1Of regulate,directly
R10743 T14336 T14339 arg1Of regulate,in
R10744 T14338 T14336 arg2Of expression,regulate
R10745 T14338 T14337 arg1Of expression,FOXP3
R10746 T14342 T14339 arg2Of fashion,in
R10747 T14342 T14340 arg1Of fashion,a
R10748 T14342 T14341 arg1Of fashion,STAT-dependent
R10749 T14342 T14343 arg1Of fashion,[
R10750 T14344 T14343 arg2Of 51,[
R10751 T14345 T14343 arg3Of ],[
R10752 T14347 T14348 arg1Of IL-13,does
R10753 T14347 T14351 arg1Of IL-13,reduce
R10754 T14347 T14354 arg1Of IL-13,fails
R10755 T14347 T14356 arg1Of IL-13,induce
R10756 T14351 T14348 arg2Of reduce,does
R10757 T14351 T14349 arg1Of reduce,not
R10758 T14351 T14350 arg1Of reduce,effectively
R10759 T14351 T14353 arg1Of reduce,and
R10760 T14352 T14351 arg2Of FOXP3,reduce
R10761 T14353 T14346 arg2Of and,Since
R10762 T14354 T14353 arg2Of fails,and
R10763 T14356 T14354 arg2Of induce,fails
R10764 T14356 T14355 arg1Of induce,to
R10765 T14357 T14356 arg2Of GATA3,induce
R10766 T14359 T14360 arg1Of we,hypothesized
R10767 T14360 T14346 arg1Of hypothesized,Since
R10768 T14360 T14358 arg1Of hypothesized,","
R10769 T14364 T14362 arg1Of inhibition,the
R10770 T14364 T14363 arg1Of inhibition,IL-4–dependent
R10771 T14364 T14365 arg1Of inhibition,of
R10772 T14364 T14367 arg1Of inhibition,could
R10773 T14364 T14368 arg1Of inhibition,be
R10774 T14364 T14369 arg2Of inhibition,mediated
R10775 T14366 T14365 arg2Of FOXP3,of
R10776 T14369 T14360 arg2Of mediated,hypothesized
R10777 T14369 T14361 arg1Of mediated,that
R10778 T14369 T14367 arg2Of mediated,could
R10779 T14369 T14368 arg2Of mediated,be
R10780 T14371 T14369 arg1Of GATA3,mediated
R10781 T14371 T14370 arg2Of GATA3,by
R10782 T14373 T14372 arg2Of fact,In
R10783 T14377 T14375 arg1Of concentrations,GATA3-inducing
R10784 T14377 T14376 arg1Of concentrations,IL-4
R10785 T14377 T14378 arg1Of concentrations,repressed
R10786 T14378 T14372 arg1Of repressed,In
R10787 T14378 T14374 arg1Of repressed,","
R10788 T14378 T14382 arg1Of repressed,","
R10789 T14378 T14383 arg1Of repressed,whereas
R10790 T14381 T14378 arg2Of expression,repressed
R10791 T14381 T14379 arg1Of expression,TGF-β–mediated
R10792 T14381 T14380 arg1Of expression,FOXP3
R10793 T14384 T14387 arg1Of IL-4,as
R10794 T14387 T14385 arg1Of as,as
R10795 T14387 T14386 arg1Of as,well
R10796 T14387 T14390 arg1Of as,were
R10797 T14387 T14391 arg1Of as,intact
R10798 T14389 T14387 arg2Of signaling,as
R10799 T14389 T14388 arg1Of signaling,TGF-β
R10800 T14390 T14383 arg2Of were,whereas
R10801 T14391 T14390 arg2Of intact,were
R10802 T14393 T14392 arg1Of result,This
R10803 T14393 T14394 arg1Of result,suggested
R10804 T14397 T14394 arg2Of mechanism,suggested
R10805 T14397 T14395 arg1Of mechanism,a
R10806 T14397 T14396 arg1Of mechanism,competitive
R10807 T14397 T14398 arg1Of mechanism,between
R10808 T14397 T14404 arg1Of mechanism,in
R10809 T14399 T14400 arg1Of GATA3,and
R10810 T14401 T14400 arg2Of FOXP3,and
R10811 T14403 T14398 arg2Of factors,between
R10812 T14403 T14399 arg1Of factors,GATA3
R10813 T14403 T14401 arg1Of factors,FOXP3
R10814 T14403 T14402 arg1Of factors,transcription
R10815 T14405 T14404 arg2Of determining,in
R10816 T14405 T14408 arg1Of determining,during
R10817 T14407 T14405 arg2Of commitment,determining
R10818 T14407 T14406 arg1Of commitment,lineage
R10819 T14411 T14408 arg2Of phase,during
R10820 T14411 T14409 arg1Of phase,the
R10821 T14411 T14410 arg1Of phase,early
R10822 T14411 T14412 arg1Of phase,of
R10823 T14413 T14412 arg2Of differentiation,of
R10824 T14416 T14417 arg1Of we,investigated
R10825 T14416 T14423 arg1Of we,confirmed
R10826 T14417 T14422 arg1Of investigated,and
R10827 T14419 T14418 arg1Of high,naturally
R10828 T14421 T14417 arg2Of cells,investigated
R10829 T14421 T14419 arg1Of cells,high
R10830 T14421 T14420 arg1Of cells,GATA3-expressing
R10831 T14422 T14414 arg1Of and,Accordingly
R10832 T14422 T14415 arg1Of and,","
R10833 T14423 T14422 arg2Of confirmed,and
R10834 T14425 T14423 arg2Of absence,confirmed
R10835 T14425 T14424 arg1Of absence,the
R10836 T14425 T14426 arg1Of absence,of
R10837 T14427 T14426 arg2Of FOXP3,of
R10838 T14429 T14428 arg1Of transduction,Protein
R10839 T14429 T14430 arg1Of transduction,of
R10840 T14429 T14432 arg1Of transduction,into
R10841 T14429 T14436 arg1Of transduction,inhibited
R10842 T14431 T14430 arg2Of GATA3,of
R10843 T14435 T14432 arg2Of cells,into
R10844 T14435 T14433 arg1Of cells,naive
R10845 T14435 T14434 arg1Of cells,T
R10846 T14438 T14436 arg2Of induction,inhibited
R10847 T14438 T14437 arg1Of induction,FOXP3
R10848 T14438 T14439 arg1Of induction,in
R10849 T14446 T14439 arg2Of cells,in
R10850 T14446 T14440 arg1Of cells,human
R10851 T14446 T14441 arg1Of cells,","
R10852 T14446 T14442 arg1Of cells,differentiating
R10853 T14446 T14443 arg1Of cells,","
R10854 T14446 T14444 arg1Of cells,naive
R10855 T14446 T14445 arg1Of cells,T
R10856 T14449 T14447 arg1Of effect,This
R10857 T14449 T14448 arg1Of effect,inhibitory
R10858 T14449 T14450 arg1Of effect,of
R10859 T14449 T14452 arg1Of effect,was
R10860 T14449 T14454 arg2Of effect,confirmed
R10861 T14449 T14460 arg1Of effect,expressing
R10862 T14451 T14450 arg2Of GATA3,of
R10863 T14454 T14452 arg2Of confirmed,was
R10864 T14454 T14453 arg1Of confirmed,further
R10865 T14454 T14455 arg1Of confirmed,in
R10866 T14454 T14459 arg1Of confirmed,","
R10867 T14454 T14460 modOf confirmed,expressing
R10868 T14458 T14455 arg2Of mice,in
R10869 T14458 T14456 arg1Of mice,BALB/c
R10870 T14458 T14457 arg1Of mice,transgenic
R10871 T14460 T14462 arg1Of expressing,in
R10872 T14461 T14460 arg2Of GATA3,expressing
R10873 T14464 T14462 arg2Of cells,in
R10874 T14464 T14463 arg1Of cells,T
R10875 T14464 T14465 arg1Of cells,(
R10876 T14466 T14465 arg2Of DO11.10,(
R10877 T14466 T14467 arg1Of DO11.10,:
R10878 T14470 T14467 arg2Of mice,:
R10879 T14470 T14468 arg1Of mice,CD2-GATA3
R10880 T14470 T14469 arg1Of mice,transgenic
R10881 T14471 T14465 arg3Of ),(
R10882 T14473 T14472 arg2Of line,In
R10883 T14473 T14474 arg1Of line,with
R10884 T14477 T14474 arg2Of overexpression,with
R10885 T14477 T14475 arg1Of overexpression,the
R10886 T14477 T14476 arg1Of overexpression,transient
R10887 T14477 T14478 arg1Of overexpression,of
R10888 T14477 T14480 arg1Of overexpression,in
R10889 T14479 T14478 arg2Of GATA3,of
R10890 T14483 T14480 arg2Of cells,in
R10891 T14483 T14481 arg1Of cells,human
R10892 T14483 T14482 arg1Of cells,T
R10893 T14485 T14486 arg1Of cells,of
R10894 T14485 T14489 arg1Of cells,failed
R10895 T14485 T14491 arg1Of cells,induce
R10896 T14488 T14486 arg2Of mice,of
R10897 T14488 T14487 arg1Of mice,these
R10898 T14489 T14472 arg1Of failed,In
R10899 T14489 T14484 arg1Of failed,","
R10900 T14491 T14489 arg2Of induce,failed
R10901 T14491 T14490 arg1Of induce,to
R10902 T14491 T14494 arg1Of induce,upon
R10903 T14493 T14491 arg2Of expression,induce
R10904 T14493 T14492 arg1Of expression,FOXP3
R10905 T14495 T14494 arg2Of exposure,upon
R10906 T14495 T14496 arg1Of exposure,with
R10907 T14497 T14496 arg2Of antigen,with
R10908 T14497 T14498 arg1Of antigen,in
R10909 T14500 T14498 arg2Of presence,in
R10910 T14500 T14499 arg1Of presence,the
R10911 T14500 T14501 arg1Of presence,of
R10912 T14502 T14501 arg2Of TGF-β,of
R10913 T14506 T14507 arg1Of DO11.10,:
R10914 T14508 T14507 arg2Of CD2-GATA3,:
R10915 T14509 T14505 arg1Of mice,the
R10916 T14509 T14506 arg1Of mice,DO11.10
R10917 T14509 T14508 arg1Of mice,CD2-GATA3
R10918 T14509 T14510 arg1Of mice,do
R10919 T14509 T14511 arg1Of mice,have
R10920 T14511 T14503 arg1Of have,Strikingly
R10921 T14511 T14504 arg1Of have,","
R10922 T14511 T14510 arg2Of have,do
R10923 T14514 T14511 arg2Of cells,have
R10924 T14514 T14512 arg1Of cells,peripheral
R10925 T14514 T14513 arg1Of cells,FOXP3+
R10926 T14514 T14515 arg1Of cells,","
R10927 T14514 T14516 arg1Of cells,which
R10928 T14514 T14518 arg1Of cells,displayed
R10929 T14518 T14517 arg1Of displayed,however
R10930 T14518 T14526 arg1Of displayed,compared
R10931 T14523 T14519 arg1Of %,a
R10932 T14523 T14520 arg1Of %,10
R10933 T14523 T14521 arg1Of %,%
R10934 T14523 T14522 arg1Of %,–25
R10935 T14524 T14523 arg1Of lower,%
R10936 T14525 T14518 arg2Of frequency,displayed
R10937 T14525 T14524 arg1Of frequency,lower
R10938 T14527 T14526 arg2Of to,compared
R10939 T14530 T14527 arg2Of mice,to
R10940 T14530 T14528 arg1Of mice,wild-type
R10941 T14530 T14529 arg1Of mice,DO11.10
R10942 T14532 T14533 arg1Of GATA3,restrains
R10943 T14533 T14531 arg1Of restrains,Thus
R10944 T14535 T14533 arg2Of development,restrains
R10945 T14535 T14534 arg1Of development,the
R10946 T14535 T14536 arg1Of development,of
R10947 T14539 T14536 arg2Of subsets,of
R10948 T14539 T14537 arg1Of subsets,certain
R10949 T14539 T14538 arg1Of subsets,Treg
R10950 T14539 T14540 arg1Of subsets,","
R10951 T14543 T14544 arg1Of inducible,","
R10952 T14545 T14544 arg2Of peripheral,","
R10953 T14546 T14542 arg1Of population,the
R10954 T14546 T14543 arg1Of population,inducible
R10955 T14546 T14545 arg1Of population,peripheral
R10956 T14546 T14547 arg1Of population,and
R10957 T14547 T14540 arg2Of and,","
R10958 T14547 T14541 arg1Of and,presumably
R10959 T14549 T14547 arg2Of those,and
R10960 T14549 T14548 arg1Of those,not
R10961 T14549 T14550 arg1Of those,of
R10962 T14552 T14550 arg2Of origin,of
R10963 T14552 T14551 arg1Of origin,thymic
R10964 T14555 T14553 arg1Of cells,Thymic
R10965 T14555 T14554 arg1Of cells,T
R10966 T14555 T14556 arg1Of cells,undergo
R10967 T14560 T14556 arg2Of process,undergo
R10968 T14560 T14557 arg1Of process,a
R10969 T14560 T14558 arg1Of process,different
R10970 T14560 T14559 arg1Of process,maturation
R10971 T14560 T14561 arg1Of process,","
R10972 T14560 T14562 arg1Of process,which
R10973 T14560 T14563 arg1Of process,may
R10974 T14560 T14564 arg1Of process,explain
R10975 T14564 T14563 arg2Of explain,may
R10976 T14564 T14572 arg1Of explain,[
R10977 T14566 T14564 arg2Of insensitivity,explain
R10978 T14566 T14565 arg1Of insensitivity,the
R10979 T14566 T14567 arg1Of insensitivity,of
R10980 T14566 T14569 arg1Of insensitivity,to
R10981 T14568 T14567 arg2Of nTreg,of
R10982 T14571 T14569 arg2Of overexpression,to
R10983 T14571 T14570 arg1Of overexpression,GATA3
R10984 T14573 T14572 arg2Of 52,[
R10985 T14574 T14572 arg3Of ],[
R10986 T14575 T14577 arg1Of In,to
R10987 T14576 T14575 arg2Of contrast,In
R10988 T14579 T14580 arg1Of Th2-differentiating,and
R10989 T14581 T14580 arg2Of iTreg-inhibiting,and
R10990 T14582 T14575 arg3Of function,In
R10991 T14582 T14578 arg1Of function,the
R10992 T14582 T14579 arg1Of function,Th2-differentiating
R10993 T14582 T14581 arg1Of function,iTreg-inhibiting
R10994 T14582 T14583 arg1Of function,of
R10995 T14582 T14585 arg1Of function,in
R10996 T14584 T14583 arg2Of GATA3,of
R10997 T14588 T14585 arg2Of cells,in
R10998 T14588 T14586 arg1Of cells,peripheral
R10999 T14588 T14587 arg1Of cells,T
R11000 T14590 T14591 arg1Of GATA3,acts
R11001 T14590 T14620 arg1Of GATA3,participates
R11002 T14590 T14627 arg1Of GATA3,regulate
R11003 T14591 T14592 arg1Of acts,in
R11004 T14591 T14619 arg1Of acts,or
R11005 T14594 T14592 arg2Of thymus,in
R11006 T14594 T14593 arg1Of thymus,the
R11007 T14594 T14595 arg1Of thymus,together
R11008 T14594 T14609 arg1Of thymus,in
R11009 T14595 T14596 arg1Of together,with
R11010 T14599 T14596 arg2Of factors,with
R11011 T14599 T14597 arg1Of factors,other
R11012 T14599 T14598 arg1Of factors,transcription
R11013 T14599 T14601 arg1Of factors,as
R11014 T14599 T14606 arg1Of factors,(
R11015 T14601 T14600 arg1Of as,such
R11016 T14603 T14601 arg2Of Repressor,as
R11017 T14603 T14602 arg1Of Repressor,the
R11018 T14603 T14604 arg1Of Repressor,of
R11019 T14605 T14604 arg2Of GATA3,of
R11020 T14607 T14606 arg2Of ROG,(
R11021 T14608 T14606 arg3Of ),(
R11022 T14612 T14609 arg2Of process,in
R11023 T14612 T14610 arg1Of process,the
R11024 T14612 T14611 arg1Of process,differentiation
R11025 T14612 T14613 arg1Of process,toward
R11026 T14615 T14613 arg2Of cells,toward
R11027 T14615 T14614 arg1Of cells,CD8
R11028 T14615 T14616 arg1Of cells,[
R11029 T14617 T14616 arg2Of "53,54",[
R11030 T14618 T14616 arg3Of ],[
R11031 T14619 T14575 arg1Of or,In
R11032 T14619 T14589 arg1Of or,","
R11033 T14620 T14619 arg2Of participates,or
R11034 T14620 T14621 arg1Of participates,in
R11035 T14620 T14626 modOf participates,to
R11036 T14625 T14621 arg2Of network,in
R11037 T14625 T14622 arg1Of network,complex
R11038 T14625 T14623 arg1Of network,transcriptional
R11039 T14625 T14624 arg1Of network,feedback
R11040 T14627 T14626 arg1Of regulate,to
R11041 T14629 T14627 arg2Of differentiation,regulate
R11042 T14629 T14628 arg1Of differentiation,sympathoadrenal
R11043 T14629 T14630 arg1Of differentiation,[
R11044 T14631 T14630 arg2Of 55,[
R11045 T14632 T14630 arg3Of ],[
R11046 T14636 T14635 arg1Of role,the
R11047 T14636 T14637 arg1Of role,of
R11048 T14636 T14639 arg1Of role,appears
R11049 T14636 T14641 arg1Of role,be
R11050 T14636 T14643 arg1Of role,specific
R11051 T14636 T14645 arg1Of role,can
R11052 T14636 T14647 arg1Of role,be
R11053 T14636 T14648 arg2Of role,generalized
R11054 T14638 T14637 arg2Of GATA3,of
R11055 T14639 T14644 arg1Of appears,and
R11056 T14641 T14639 arg2Of be,appears
R11057 T14641 T14640 arg1Of be,to
R11058 T14643 T14641 arg2Of specific,be
R11059 T14643 T14642 arg1Of specific,tissue
R11060 T14644 T14633 arg1Of and,Therefore
R11061 T14644 T14634 arg1Of and,","
R11062 T14648 T14644 arg2Of generalized,and
R11063 T14648 T14645 arg2Of generalized,can
R11064 T14648 T14646 arg1Of generalized,not
R11065 T14648 T14647 arg2Of generalized,be
R11066 T14650 T14649 arg1Of study,Our
R11067 T14650 T14651 arg1Of study,demonstrates
R11068 T14653 T14654 arg1Of GATA3,repressed
R11069 T14653 T14659 arg1Of GATA3,binding
R11070 T14654 T14651 arg2Of repressed,demonstrates
R11071 T14654 T14652 arg1Of repressed,that
R11072 T14654 T14657 arg1Of repressed,directly
R11073 T14654 T14658 arg1Of repressed,by
R11074 T14656 T14654 arg2Of expression,repressed
R11075 T14656 T14655 arg1Of expression,FOXP3
R11076 T14659 T14658 arg2Of binding,by
R11077 T14659 T14660 arg1Of binding,to
R11078 T14664 T14660 arg2Of region,to
R11079 T14664 T14661 arg1Of region,the
R11080 T14664 T14662 arg1Of region,FOXP3
R11081 T14664 T14663 arg1Of region,promoter
R11082 T14667 T14665 arg1Of GATA-site,A
R11083 T14667 T14666 arg1Of GATA-site,palindromic
R11084 T14667 T14668 arg1Of GATA-site,is
R11085 T14667 T14669 arg1Of GATA-site,located
R11086 T14669 T14668 arg2Of located,is
R11087 T14669 T14671 arg1Of located,bp
R11088 T14671 T14670 arg1Of bp,303
R11089 T14671 T14672 arg1Of bp,upstream
R11090 T14672 T14673 arg1Of upstream,of
R11091 T14675 T14673 arg2Of TSS,of
R11092 T14675 T14674 arg1Of TSS,the
R11093 T14675 T14676 arg1Of TSS,in
R11094 T14679 T14678 arg1Of conserved,highly
R11095 T14680 T14676 arg2Of region,in
R11096 T14680 T14677 arg1Of region,a
R11097 T14680 T14679 arg1Of region,conserved
R11098 T14680 T14681 arg1Of region,","
R11099 T14680 T14682 arg1Of region,which
R11100 T14680 T14686 arg2Of region,identified
R11101 T14683 T14684 arg1Of we,have
R11102 T14683 T14686 arg1Of we,identified
R11103 T14686 T14684 arg2Of identified,have
R11104 T14686 T14685 arg1Of identified,previously
R11105 T14686 T14687 arg1Of identified,as
R11106 T14686 T14691 arg1Of identified,[
R11107 T14690 T14687 arg2Of promoter,as
R11108 T14690 T14688 arg1Of promoter,the
R11109 T14690 T14689 arg1Of promoter,FOXP3
R11110 T14692 T14691 arg2Of 24,[
R11111 T14693 T14691 arg3Of ],[
R11112 T14695 T14694 arg1Of mutation,Site-specific
R11113 T14695 T14696 arg1Of mutation,of
R11114 T14695 T14699 arg1Of mutation,increased
R11115 T14698 T14696 arg2Of site,of
R11116 T14698 T14697 arg1Of site,this
R11117 T14699 T14706 arg1Of increased,","
R11118 T14699 T14708 modOf increased,revealing
R11119 T14701 T14699 arg2Of activity,increased
R11120 T14701 T14700 arg1Of activity,the
R11121 T14701 T14702 arg1Of activity,of
R11122 T14705 T14702 arg2Of constructs,of
R11123 T14705 T14703 arg1Of constructs,the
R11124 T14705 T14704 arg1Of constructs,promoter
R11125 T14708 T14707 arg1Of revealing,thus
R11126 T14711 T14708 arg2Of nature,revealing
R11127 T14711 T14709 arg1Of nature,the
R11128 T14711 T14710 arg1Of nature,repressive
R11129 T14711 T14712 arg1Of nature,of
R11130 T14715 T14712 arg2Of element,of
R11131 T14715 T14713 arg1Of element,this
R11132 T14715 T14714 arg1Of element,GATA
R11133 T14715 T14716 arg1Of element,in
R11134 T14719 T14716 arg2Of cells,in
R11135 T14719 T14717 arg1Of cells,memory
R11136 T14719 T14718 arg1Of cells,T
R11137 T14719 T14720 arg1Of cells,","
R11138 T14719 T14721 arg1Of cells,which
R11139 T14719 T14723 arg1Of cells,express
R11140 T14723 T14722 arg1Of express,naturally
R11141 T14723 T14725 arg1Of express,","
R11142 T14723 T14726 arg1Of express,whereas
R11143 T14724 T14723 arg2Of GATA3,express
R11144 T14728 T14727 arg1Of difference,no
R11145 T14728 T14729 arg1Of difference,was
R11146 T14728 T14730 arg2Of difference,seen
R11147 T14730 T14726 arg2Of seen,whereas
R11148 T14730 T14729 arg2Of seen,was
R11149 T14730 T14731 arg1Of seen,in
R11150 T14734 T14731 arg2Of cells,in
R11151 T14734 T14732 arg1Of cells,naive
R11152 T14734 T14733 arg1Of cells,T
R11153 T14734 T14735 arg1Of cells,","
R11154 T14734 T14736 arg1Of cells,which
R11155 T14734 T14737 arg1Of cells,do
R11156 T14734 T14739 arg1Of cells,express
R11157 T14739 T14737 arg2Of express,do
R11158 T14739 T14738 arg1Of express,not
R11159 T14740 T14739 arg2Of GATA3,express
R11160 T14744 T14741 arg1Of element,This
R11161 T14744 T14742 arg1Of element,palindromic
R11162 T14744 T14743 arg1Of element,GATA
R11163 T14744 T14745 arg1Of element,is
R11164 T14744 T14746 arg2Of element,bound
R11165 T14746 T14745 arg2Of bound,is
R11166 T14746 T14750 arg1Of bound,as
R11167 T14749 T14746 arg1Of protein,bound
R11168 T14749 T14747 arg2Of protein,by
R11169 T14749 T14748 arg1Of protein,GATA3
R11170 T14751 T14750 arg2Of proven,as
R11171 T14751 T14752 arg1Of proven,with
R11172 T14754 T14752 arg2Of experiments,with
R11173 T14754 T14753 arg1Of experiments,pull-down
R11174 T14757 T14758 arg1Of it,is
R11175 T14757 T14759 arg2Of it,shown
R11176 T14759 T14755 arg1Of shown,Furthermore
R11177 T14759 T14756 arg1Of shown,","
R11178 T14759 T14758 arg2Of shown,is
R11179 T14761 T14759 arg1Of ChIP,shown
R11180 T14761 T14760 arg2Of ChIP,by
R11181 T14763 T14764 arg1Of GATA3,binds
R11182 T14764 T14759 arg3Of binds,shown
R11183 T14764 T14762 arg1Of binds,that
R11184 T14764 T14767 arg1Of binds,also
R11185 T14764 T14768 arg1Of binds,in
R11186 T14766 T14764 arg2Of element,binds
R11187 T14766 T14765 arg1Of element,this
R11188 T14770 T14768 arg2Of cells,in
R11189 T14770 T14769 arg1Of cells,intact
R11190 T14771 T14772 arg1Of It,is
R11191 T14771 T14773 arg2Of It,known
R11192 T14773 T14772 arg2Of known,is
R11193 T14775 T14776 arg1Of GATA3,can
R11194 T14775 T14777 arg1Of GATA3,induce
R11195 T14775 T14788 arg1Of GATA3,transactivating
R11196 T14775 T14797 arg2Of GATA3,shown
R11197 T14775 T14803 arg1Of GATA3,acts
R11198 T14777 T14776 arg2Of induce,can
R11199 T14777 T14782 arg1Of induce,[
R11200 T14777 T14785 arg1Of induce,","
R11201 T14777 T14786 arg1Of induce,by
R11202 T14777 T14793 arg1Of induce,","
R11203 T14777 T14794 arg1Of induce,or
R11204 T14777 T14795 arg1Of induce,","
R11205 T14778 T14777 arg2Of transcription,induce
R11206 T14778 T14779 arg1Of transcription,by
R11207 T14780 T14779 arg2Of chromatin,by
R11208 T14780 T14781 arg1Of chromatin,remodeling
R11209 T14783 T14782 arg2Of 56,[
R11210 T14784 T14782 arg3Of ],[
R11211 T14788 T14786 arg2Of transactivating,by
R11212 T14788 T14787 arg1Of transactivating,directly
R11213 T14789 T14788 arg2Of promoters,transactivating
R11214 T14789 T14790 arg1Of promoters,[
R11215 T14791 T14790 arg2Of 36,[
R11216 T14792 T14790 arg3Of ],[
R11217 T14795 T14773 arg3Of ",",known
R11218 T14795 T14774 arg1Of ",",that
R11219 T14797 T14796 arg2Of shown,as
R11220 T14797 T14798 arg1Of shown,in
R11221 T14801 T14798 arg2Of study,in
R11222 T14801 T14799 arg1Of study,the
R11223 T14801 T14800 arg1Of study,current
R11224 T14803 T14795 arg2Of acts,","
R11225 T14803 T14796 arg1Of acts,as
R11226 T14803 T14802 arg1Of acts,","
R11227 T14803 T14804 arg1Of acts,as
R11228 T14806 T14804 arg2Of repressor,as
R11229 T14806 T14805 arg1Of repressor,a
R11230 T14806 T14807 arg1Of repressor,of
R11231 T14809 T14807 arg2Of expression,of
R11232 T14809 T14808 arg1Of expression,gene
R11233 T14809 T14810 arg1Of expression,[
R11234 T14811 T14810 arg2Of "21,57–59",[
R11235 T14812 T14810 arg3Of ],[
R11236 T14816 T14814 arg1Of expression,keeping
R11237 T14816 T14815 arg1Of expression,GATA3
R11238 T14816 T14817 arg1Of expression,low
R11239 T14816 T14818 arg1Of expression,might
R11240 T14816 T14819 arg1Of expression,be
R11241 T14816 T14820 arg2Of expression,required
R11242 T14816 T14822 arg1Of expression,induce
R11243 T14820 T14813 arg1Of required,Therefore
R11244 T14820 T14818 arg2Of required,might
R11245 T14820 T14819 arg2Of required,be
R11246 T14822 T14820 arg3Of induce,required
R11247 T14822 T14821 arg1Of induce,to
R11248 T14827 T14822 arg2Of generation,induce
R11249 T14827 T14823 arg1Of generation,efficient
R11250 T14827 T14824 arg1Of generation,FOXP3+
R11251 T14827 T14825 arg1Of generation,iTreg
R11252 T14827 T14826 arg1Of generation,cell
R11253 T14830 T14828 arg1Of interactions,The
R11254 T14830 T14829 arg1Of interactions,molecular
R11255 T14830 T14831 arg1Of interactions,enabling
R11256 T14830 T14836 arg1Of interactions,are
R11257 T14830 T14838 arg2Of interactions,identified
R11258 T14832 T14831 arg2Of GATA3,enabling
R11259 T14832 T14833 modOf GATA3,to
R11260 T14834 T14833 arg1Of inhibit,to
R11261 T14835 T14834 arg2Of FOXP3,inhibit
R11262 T14838 T14836 arg2Of identified,are
R11263 T14838 T14837 arg1Of identified,not
R11264 T14838 T14839 arg1Of identified,yet
R11265 T14838 T14841 arg1Of identified,but
R11266 T14841 T14840 arg1Of but,","
R11267 T14844 T14842 arg1Of site,the
R11268 T14844 T14843 arg1Of site,GATA-binding
R11269 T14844 T14845 arg1Of site,is
R11270 T14844 T14846 arg2Of site,located
R11271 T14844 T14851 arg1Of site,inducing
R11272 T14846 T14845 arg2Of located,is
R11273 T14846 T14847 arg1Of located,adjacent
R11274 T14846 T14848 arg1Of located,to
R11275 T14846 T14850 arg1Of located,","
R11276 T14846 T14851 modOf located,inducing
R11277 T14846 T14862 arg1Of located,and
R11278 T14849 T14848 arg2Of positive,to
R11279 T14852 T14851 arg2Of sites,inducing
R11280 T14852 T14853 arg1Of sites,","
R11281 T14852 T14854 arg2Of sites,composed
R11282 T14854 T14855 arg1Of composed,of
R11283 T14857 T14855 arg2Of sites,of
R11284 T14857 T14856 arg1Of sites,AP-1-NFATc2
R11285 T14857 T14858 arg1Of sites,[
R11286 T14859 T14858 arg2Of 24,[
R11287 T14860 T14858 arg3Of ],[
R11288 T14862 T14841 arg2Of and,but
R11289 T14862 T14861 arg1Of and,","
R11290 T14863 T14864 arg1Of GATA3,may
R11291 T14863 T14865 arg1Of GATA3,compete
R11292 T14865 T14862 arg2Of compete,and
R11293 T14865 T14864 arg2Of compete,may
R11294 T14865 T14866 arg1Of compete,with
R11295 T14868 T14866 arg2Of binding,with
R11296 T14868 T14867 arg1Of binding,the
R11297 T14868 T14869 arg1Of binding,of
R11298 T14868 T14871 arg1Of binding,to
R11299 T14870 T14869 arg2Of AP-1/NFAT,of
R11300 T14873 T14871 arg2Of promoter,to
R11301 T14873 T14872 arg1Of promoter,the
R11302 T14873 T14874 arg1Of promoter,(
R11303 T14876 T14874 arg2Of observations,(
R11304 T14876 T14875 arg1Of observations,unpublished
R11305 T14877 T14874 arg3Of ),(
R11306 T14879 T14878 arg2Of summary,In
R11307 T14881 T14882 arg1Of we,demonstrated
R11308 T14882 T14878 arg1Of demonstrated,In
R11309 T14882 T14880 arg1Of demonstrated,","
R11310 T14884 T14885 arg1Of FOXP3,is
R11311 T14884 T14887 arg2Of FOXP3,regulated
R11312 T14887 T14882 arg2Of regulated,demonstrated
R11313 T14887 T14883 arg1Of regulated,that
R11314 T14887 T14885 arg2Of regulated,is
R11315 T14887 T14886 arg1Of regulated,negatively
R11316 T14889 T14887 arg1Of cytokines,regulated
R11317 T14889 T14888 arg2Of cytokines,by
R11318 T14889 T14891 arg1Of cytokines,as
R11319 T14891 T14890 arg1Of as,such
R11320 T14892 T14891 arg2Of IL-4,as
R11321 T14893 T14894 arg1Of GATA3,acts
R11322 T14894 T14895 arg1Of acts,as
R11323 T14894 T14910 arg1Of acts,in
R11324 T14894 T14914 arg1Of acts,by
R11325 T14895 T14909 arg1Of as,as
R11326 T14897 T14895 arg2Of inhibitor,as
R11327 T14897 T14896 arg1Of inhibitor,an
R11328 T14897 T14898 arg1Of inhibitor,of
R11329 T14900 T14898 arg2Of expression,of
R11330 T14900 T14899 arg1Of expression,FOXP3
R11331 T14900 T14901 arg1Of expression,in
R11332 T14905 T14901 arg2Of differentiation,in
R11333 T14905 T14902 arg1Of differentiation,early
R11334 T14905 T14903 arg1Of differentiation,T
R11335 T14905 T14904 arg1Of differentiation,cell
R11336 T14909 T14906 arg1Of as,","
R11337 T14909 T14907 arg1Of as,as
R11338 T14909 T14908 arg1Of as,well
R11339 T14910 T14909 arg2Of in,as
R11340 T14913 T14910 arg2Of cells,in
R11341 T14913 T14911 arg2Of cells,differentiated
R11342 T14913 T14912 arg1Of cells,Th2
R11343 T14916 T14917 arg1Of binding,and
R11344 T14917 T14914 arg2Of and,by
R11345 T14917 T14915 arg1Of and,directly
R11346 T14918 T14917 arg2Of repressing,and
R11347 T14921 T14916 arg2Of promoter,binding
R11348 T14921 T14918 arg2Of promoter,repressing
R11349 T14921 T14919 arg1Of promoter,the
R11350 T14921 T14920 arg1Of promoter,FOXP3
R11351 T14922 T14924 arg1Of We,describe
R11352 T14922 T14935 arg1Of We,repressing
R11353 T14924 T14923 arg1Of describe,therefore
R11354 T14924 T14934 arg1Of describe,by
R11355 T14927 T14924 arg2Of mechanism,describe
R11356 T14927 T14925 arg1Of mechanism,a
R11357 T14927 T14926 arg1Of mechanism,new
R11358 T14927 T14928 arg1Of mechanism,of
R11359 T14933 T14928 arg2Of induction,of
R11360 T14933 T14929 arg1Of induction,how
R11361 T14933 T14930 arg1Of induction,Il-4
R11362 T14933 T14931 arg1Of induction,avoids
R11363 T14933 T14932 arg1Of induction,tolerance
R11364 T14935 T14934 arg2Of repressing,by
R11365 T14937 T14935 arg2Of expression,repressing
R11366 T14937 T14936 arg1Of expression,FOXP3
R11367 T14939 T14938 arg1Of findings,These
R11368 T14939 T14940 arg1Of findings,will
R11369 T14939 T14941 arg1Of findings,give
R11370 T14941 T14940 arg2Of give,will
R11371 T14941 T14944 arg1Of give,toward
R11372 T14943 T14941 arg2Of perspectives,give
R11373 T14943 T14942 arg1Of perspectives,new
R11374 T14945 T14944 arg2Of understanding,toward
R11375 T14945 T14958 arg1Of understanding,","
R11376 T14945 T14960 arg1Of understanding,in
R11377 T14947 T14945 arg2Of mechanisms,understanding
R11378 T14947 T14946 arg1Of mechanisms,molecular
R11379 T14947 T14948 arg1Of mechanisms,of
R11380 T14950 T14949 arg1Of induction,iTreg
R11381 T14950 T14951 arg1Of induction,and
R11382 T14951 T14948 arg2Of and,of
R11383 T14953 T14951 arg2Of pathways,and
R11384 T14953 T14952 arg1Of pathways,thus
R11385 T14953 T14954 arg1Of pathways,of
R11386 T14957 T14954 arg2Of induction,of
R11387 T14957 T14955 arg1Of induction,peripheral
R11388 T14957 T14956 arg1Of induction,tolerance
R11389 T14960 T14959 arg1Of in,particularly
R11390 T14961 T14962 arg1Of allergy,and
R11391 T14962 T14960 arg2Of and,in
R11392 T14963 T14962 arg2Of asthma,and

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T14964 946-959 Anaphor denotes these factors
T14965 867-872 Antecedent denotes T-bet
T14966 877-882 Antecedent denotes GATA3
T14967 1356-1376 Anaphor denotes polarization factors
T14968 1391-1395 Antecedent denotes IL-4
T14969 1397-1402 Antecedent denotes IL-12
T14970 1407-1412 Antecedent denotes TGF-β
T14971 3556-3576 Anaphor denotes these concentrations
T14972 3481-3485 Antecedent denotes IL-4
T14973 7034-7043 Anaphor denotes cytokines
T14974 7052-7056 Antecedent denotes IL-4
R11393 T14964 T14965 boundBy these factors,T-bet
R11394 T14964 T14966 boundBy these factors,GATA3
R11395 T14967 T14968 boundBy polarization factors,IL-4
R11396 T14967 T14969 boundBy polarization factors,IL-12
R11397 T14967 T14970 boundBy polarization factors,TGF-β
R11398 T14971 T14972 boundBy these concentrations,IL-4
R11399 T14973 T14974 boundBy cytokines,IL-4

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T15144 11-14 DT denotes The
T15145 15-22 JJ denotes current
T15146 23-28 NN denotes study
T15147 29-36 VBZ denotes reveals
T15148 37-41 IN denotes that
T15149 42-47 CD denotes FOXP3
T15150 48-57 NN denotes induction
T15151 57-58 , denotes ,
T15152 59-61 DT denotes an
T15153 62-71 JJ denotes important
T15154 72-76 NN denotes step
T15155 77-79 IN denotes in
T15156 80-85 NNP denotes iTreg
T15157 86-96 NN denotes commitment
T15158 96-97 , denotes ,
T15159 98-100 VBZ denotes is
T15160 101-110 VBN denotes inhibited
T15161 111-113 IN denotes by
T15162 114-119 NNP denotes GATA3
T15163 119-120 , denotes ,
T15164 121-126 WDT denotes which
T15165 127-129 VBZ denotes is
T15166 130-133 DT denotes the
T15167 134-137 JJ denotes key
T15168 138-147 NN denotes regulator
T15169 148-151 IN denotes for
T15170 152-164 NN denotes polarization
T15171 165-171 IN denotes toward
T15172 172-175 JJ denotes Th2
T15173 176-181 NNS denotes cells
T15174 181-182 . denotes .
T15175 183-188 IN denotes After
T15176 189-204 NN denotes differentiation
T15177 204-205 , denotes ,
T15178 206-209 DT denotes the
T15179 210-218 NN denotes effector
T15180 219-222 JJ denotes Th2
T15181 223-228 NNS denotes cells
T15182 229-235 VBP denotes become
T15183 236-246 JJ denotes refractory
T15184 247-249 TO denotes to
T15185 250-260 NN denotes conversion
T15186 261-265 IN denotes into
T15187 266-267 DT denotes a
T15188 268-273 CD denotes FOXP3
T15189 273-274 NN denotes +
T15190 275-284 NN denotes phenotype
T15191 284-285 . denotes .
T15192 286-288 IN denotes In
T15193 289-299 NN denotes accordance
T15194 300-304 IN denotes with
T15195 305-310 JJ denotes other
T15196 311-318 NNS denotes studies
T15197 318-319 , denotes ,
T15198 320-322 PRP denotes we
T15199 323-328 VBD denotes found
T15200 329-333 IN denotes that
T15201 334-337 CD denotes CD4
T15202 337-338 CD denotes +
T15203 338-342 NNS denotes CD25
T15204 344-349 NNS denotes cells
T15205 350-354 VBD denotes were
T15206 355-359 JJ denotes able
T15207 360-362 TO denotes to
T15208 363-374 VB denotes up-regulate
T15209 375-380 CD denotes FOXP3
T15210 381-382 NNP denotes [
T15211 382-387 CD denotes 12,27
T15212 387-388 NNP denotes ]
T15213 388-389 . denotes .
T15214 390-407 JJ denotes Already-committed
T15215 408-413 NNS denotes cells
T15216 414-418 JJ denotes such
T15217 419-421 IN denotes as
T15218 422-428 NN denotes memory
T15219 429-430 NNP denotes T
T15220 431-436 NNS denotes cells
T15221 437-440 CC denotes and
T15222 441-444 JJ denotes Th1
T15223 445-450 NNS denotes cells
T15224 451-457 VBD denotes showed
T15225 458-462 RB denotes only
T15226 463-471 JJ denotes moderate
T15227 472-475 CC denotes and
T15228 476-485 JJ denotes transient
T15229 486-491 CD denotes FOXP3
T15230 492-501 NN denotes induction
T15231 501-502 , denotes ,
T15232 503-508 WDT denotes which
T15233 509-511 VBZ denotes is
T15234 512-515 RB denotes not
T15235 516-526 JJ denotes sufficient
T15236 527-529 TO denotes to
T15237 530-536 VB denotes change
T15238 537-540 DT denotes the
T15239 541-550 NN denotes phenotype
T15240 551-557 IN denotes toward
T15241 558-559 DT denotes a
T15242 560-570 JJ denotes regulatory
T15243 571-572 NNP denotes T
T15244 573-577 NN denotes cell
T15245 578-585 NN denotes profile
T15246 585-586 . denotes .
T15247 587-589 IN denotes In
T15248 590-598 NN denotes contrast
T15249 598-599 , denotes ,
T15250 600-605 JJ denotes naive
T15251 606-607 NNP denotes T
T15252 608-613 NNS denotes cells
T15253 614-619 MD denotes could
T15254 620-631 RB denotes efficiently
T15255 632-643 VB denotes up-regulate
T15256 644-649 CD denotes FOXP3
T15257 650-654 WRB denotes when
T15258 655-662 VBN denotes treated
T15259 663-667 IN denotes with
T15260 668-673 JJ denotes TGF-β
T15261 674-676 TO denotes to
T15262 677-683 VB denotes induce
T15263 684-689 NNP denotes iTreg
T15264 690-695 NNS denotes cells
T15265 696-697 NNP denotes [
T15266 697-702 CD denotes 10,28
T15267 703-705 CD denotes 34
T15268 705-706 NNP denotes ]
T15269 706-707 , denotes ,
T15270 708-718 VBG denotes suggesting
T15271 719-723 IN denotes that
T15272 724-729 CD denotes FOXP3
T15273 730-735 VBZ denotes plays
T15274 736-738 DT denotes an
T15275 739-748 JJ denotes important
T15276 749-753 NN denotes role
T15277 754-756 IN denotes in
T15278 757-760 DT denotes the
T15279 761-766 JJ denotes early
T15280 767-782 NN denotes differentiation
T15281 783-790 NN denotes process
T15282 791-794 CC denotes and
T15283 795-798 MD denotes may
T15284 799-802 VB denotes act
T15285 803-805 IN denotes in
T15286 806-807 DT denotes a
T15287 808-811 NN denotes way
T15288 812-819 JJ denotes similar
T15289 820-822 TO denotes to
T15290 823-827 DT denotes that
T15291 828-833 VBN denotes known
T15292 834-837 IN denotes for
T15293 838-841 DT denotes the
T15294 842-849 NNP denotes Th1/Th2
T15295 850-858 NN denotes decision
T15296 859-866 NNS denotes factors
T15297 867-872 NNP denotes T-bet
T15298 873-876 CC denotes and
T15299 877-882 NNP denotes GATA3
T15300 882-883 . denotes .
T15301 884-888 DT denotes This
T15302 889-899 NN denotes commitment
T15303 900-902 VBZ denotes is
T15304 903-916 VBN denotes characterized
T15305 917-919 IN denotes by
T15306 920-931 JJ denotes competitive
T15307 932-942 NN denotes expression
T15308 943-945 IN denotes of
T15309 946-951 DT denotes these
T15310 952-959 NNS denotes factors
T15311 960-961 NNP denotes [
T15312 961-966 CD denotes 35,36
T15313 966-967 NNP denotes ]
T15314 967-968 , denotes ,
T15315 969-974 WDT denotes which
T15316 975-977 PRP denotes we
T15317 978-982 RB denotes also
T15318 983-991 VBD denotes observed
T15319 992-994 IN denotes in
T15320 995-1010 VBG denotes differentiating
T15321 1011-1016 CD denotes FOXP3
T15322 1016-1017 CD denotes +
T15323 1018-1023 NNP denotes iTreg
T15324 1024-1029 NNS denotes cells
T15325 1030-1039 VBG denotes including
T15326 1040-1041 DT denotes a
T15327 1042-1047 NN denotes phase
T15328 1048-1050 IN denotes of
T15329 1051-1064 NN denotes co-expression
T15330 1064-1065 , denotes ,
T15331 1066-1071 WDT denotes which
T15332 1072-1077 VBZ denotes turns
T15333 1078-1082 IN denotes into
T15334 1083-1097 VBG denotes nonoverlapping
T15335 1098-1108 NN denotes expression
T15336 1109-1113 IN denotes upon
T15337 1114-1123 VBN denotes completed
T15338 1124-1139 NN denotes differentiation
T15339 1139-1140 . denotes .
T15340 1141-1143 IN denotes In
T15341 1144-1148 DT denotes this
T15342 1149-1160 JJ denotes competitive
T15343 1161-1168 NN denotes process
T15344 1169-1174 NN denotes TGF-β
T15345 1175-1183 VBD denotes appeared
T15346 1184-1186 TO denotes to
T15347 1187-1189 VB denotes be
T15348 1190-1199 JJ denotes mandatory
T15349 1200-1203 IN denotes for
T15350 1204-1207 DT denotes the
T15351 1208-1217 NN denotes induction
T15352 1218-1220 IN denotes of
T15353 1221-1226 CD denotes FOXP3
T15354 1226-1227 , denotes ,
T15355 1228-1236 RB denotes possibly
T15356 1237-1239 IN denotes by
T15357 1240-1247 VBG denotes keeping
T15358 1248-1251 DT denotes the
T15359 1252-1262 NN denotes expression
T15360 1263-1265 IN denotes of
T15361 1266-1271 NNP denotes GATA3
T15362 1272-1275 CC denotes and
T15363 1276-1281 NNP denotes T-bet
T15364 1282-1285 JJ denotes low
T15365 1286-1287 NNP denotes [
T15366 1287-1292 CD denotes 37,38
T15367 1292-1293 NNP denotes ]
T15368 1293-1294 . denotes .
T15369 1295-1297 IN denotes In
T15370 1298-1306 NN denotes contrast
T15371 1306-1307 , denotes ,
T15372 1308-1323 VBG denotes differentiating
T15373 1324-1329 JJ denotes naive
T15374 1330-1331 NNP denotes T
T15375 1332-1337 NNS denotes cells
T15376 1338-1340 IN denotes in
T15377 1341-1344 DT denotes the
T15378 1345-1352 NN denotes absence
T15379 1353-1355 IN denotes of
T15380 1356-1368 NN denotes polarization
T15381 1369-1376 NNS denotes factors
T15382 1377-1378 -LRB- denotes (
T15383 1378-1381 CD denotes Th0
T15384 1381-1382 -RRB- denotes )
T15385 1383-1387 JJ denotes such
T15386 1388-1390 IN denotes as
T15387 1391-1395 NN denotes IL-4
T15388 1395-1396 , denotes ,
T15389 1397-1402 NN denotes IL-12
T15390 1402-1403 , denotes ,
T15391 1404-1406 CC denotes or
T15392 1407-1412 JJ denotes TGF-β
T15393 1413-1419 VBD denotes showed
T15394 1420-1424 RB denotes only
T15395 1425-1426 DT denotes a
T15396 1427-1436 NN denotes transient
T15397 1437-1442 CD denotes FOXP3
T15398 1443-1453 NN denotes expression
T15399 1454-1457 CC denotes and
T15400 1458-1464 VBD denotes failed
T15401 1465-1467 TO denotes to
T15402 1468-1476 VB denotes generate
T15403 1477-1478 DT denotes a
T15404 1479-1489 NN denotes population
T15405 1490-1492 IN denotes of
T15406 1493-1509 JJ denotes FOXP3-expressing
T15407 1510-1515 NNS denotes cells
T15408 1515-1516 , denotes ,
T15409 1517-1520 CC denotes but
T15410 1521-1526 NNP denotes GATA3
T15411 1527-1530 CC denotes and
T15412 1531-1536 NNP denotes T-bet
T15413 1537-1541 VBD denotes were
T15414 1542-1554 JJ denotes up-regulated
T15415 1555-1556 -LRB- denotes (
T15416 1556-1567 JJ denotes unpublished
T15417 1568-1572 NNS denotes data
T15418 1572-1573 -RRB- denotes )
T15419 1573-1574 . denotes .
T15420 1575-1588 RB denotes Interestingly
T15421 1588-1589 , denotes ,
T15422 1590-1592 IN denotes as
T15423 1593-1595 PRP denotes we
T15424 1596-1599 CC denotes and
T15425 1600-1606 NNS denotes others
T15426 1607-1617 RB denotes previously
T15427 1618-1627 VBN denotes described
T15428 1627-1628 , denotes ,
T15429 1629-1644 JJ denotes FOXP3-promoting
T15430 1645-1652 NNS denotes factors
T15431 1652-1653 , denotes ,
T15432 1654-1658 JJ denotes such
T15433 1659-1661 IN denotes as
T15434 1662-1675 VBN denotes dexamethasone
T15435 1676-1677 NNP denotes [
T15436 1677-1679 CD denotes 39
T15437 1679-1680 NNP denotes ]
T15438 1680-1681 , denotes ,
T15439 1682-1688 NNP denotes CTLA-4
T15440 1689-1690 NNP denotes [
T15441 1690-1692 CD denotes 40
T15442 1692-1693 NNP denotes ]
T15443 1693-1694 , denotes ,
T15444 1695-1698 CC denotes and
T15445 1699-1708 VBZ denotes estrogens
T15446 1709-1710 NNP denotes [
T15447 1710-1712 CD denotes 41
T15448 1712-1713 NNP denotes ]
T15449 1713-1714 , denotes ,
T15450 1715-1718 VBP denotes are
T15451 1719-1723 RB denotes also
T15452 1724-1729 VBN denotes known
T15453 1730-1732 IN denotes as
T15454 1733-1743 NNS denotes inhibitors
T15455 1744-1746 IN denotes of
T15456 1747-1752 NNP denotes GATA3
T15457 1753-1763 NN denotes expression
T15458 1764-1765 NNP denotes [
T15459 1765-1767 CD denotes 42
T15460 1768-1770 CD denotes 45
T15461 1770-1771 NN denotes ]
T15462 1771-1772 . denotes .
T15463 1773-1782 RB denotes Therefore
T15464 1783-1788 NNP denotes GATA3
T15465 1789-1792 RB denotes not
T15466 1793-1797 RB denotes only
T15467 1798-1805 VBZ denotes induces
T15468 1806-1821 NN denotes differentiation
T15469 1822-1826 IN denotes into
T15470 1827-1830 JJ denotes Th2
T15471 1831-1836 NNS denotes cells
T15472 1837-1840 CC denotes but
T15473 1841-1845 RB denotes also
T15474 1846-1854 VBZ denotes inhibits
T15475 1855-1860 CD denotes FOXP3
T15476 1861-1871 NN denotes expression
T15477 1872-1875 CC denotes and
T15478 1876-1886 NN denotes commitment
T15479 1887-1891 IN denotes into
T15480 1892-1897 NNP denotes iTreg
T15481 1898-1903 NNS denotes cells
T15482 1903-1904 . denotes .
T15483 1905-1908 DT denotes The
T15484 1909-1912 JJ denotes Th2
T15485 1913-1921 NN denotes cytokine
T15486 1922-1926 NN denotes IL-4
T15487 1927-1930 CC denotes but
T15488 1931-1934 RB denotes not
T15489 1935-1940 JJ denotes IL-13
T15490 1941-1942 -LRB- denotes (
T15491 1942-1953 JJ denotes unpublished
T15492 1954-1958 NNS denotes data
T15493 1958-1959 -RRB- denotes )
T15494 1960-1963 VBD denotes was
T15495 1964-1968 JJ denotes able
T15496 1969-1971 TO denotes to
T15497 1972-1979 VB denotes inhibit
T15498 1980-1985 NNP denotes TGF-β
T15499 1986-1994 VBD denotes mediated
T15500 1995-2000 CD denotes FOXP3
T15501 2001-2010 NN denotes induction
T15502 2011-2014 CC denotes and
T15503 2015-2024 RB denotes therefore
T15504 2025-2034 VBD denotes prevented
T15505 2035-2045 NN denotes conversion
T15506 2046-2050 IN denotes into
T15507 2051-2054 DT denotes the
T15508 2055-2065 JJ denotes regulatory
T15509 2066-2075 NN denotes phenotype
T15510 2075-2076 . denotes .
T15511 2077-2079 TO denotes To
T15512 2080-2085 VB denotes prove
T15513 2086-2089 DT denotes the
T15514 2090-2100 JJ denotes inhibitory
T15515 2101-2107 NN denotes effect
T15516 2108-2110 IN denotes of
T15517 2111-2115 NN denotes IL-4
T15518 2116-2118 IN denotes on
T15519 2119-2128 JJ denotes inducible
T15520 2129-2131 CC denotes or
T15521 2132-2139 JJ denotes natural
T15522 2140-2144 NNP denotes Treg
T15523 2145-2155 NN denotes commitment
T15524 2156-2158 IN denotes in
T15525 2159-2163 NN denotes vivo
T15526 2163-2164 , denotes ,
T15527 2165-2167 PRP denotes we
T15528 2168-2175 VBD denotes treated
T15529 2176-2180 NNS denotes mice
T15530 2181-2185 IN denotes with
T15531 2186-2190 NN denotes IL-4
T15532 2191-2194 CC denotes and
T15533 2195-2204 NN denotes anti-IL-4
T15534 2204-2205 . denotes .
T15535 2206-2210 DT denotes This
T15536 2211-2214 VBZ denotes has
T15537 2215-2219 VBN denotes been
T15538 2220-2225 VBN denotes shown
T15539 2226-2228 TO denotes to
T15540 2229-2237 VB denotes increase
T15541 2238-2241 DT denotes the
T15542 2242-2248 NN denotes effect
T15543 2249-2251 IN denotes of
T15544 2252-2255 DT denotes the
T15545 2256-2264 NN denotes cytokine
T15546 2265-2267 IN denotes in
T15547 2268-2272 NN denotes vivo
T15548 2273-2274 NNP denotes [
T15549 2274-2276 CD denotes 19
T15550 2276-2277 NNP denotes ]
T15551 2277-2278 . denotes .
T15552 2279-2283 RB denotes Only
T15553 2284-2287 DT denotes the
T15554 2288-2292 NN denotes IL-4
T15555 2292-2293 NN denotes /
T15556 2293-2297 NN denotes IL-4
T15557 2298-2301 NNP denotes mAb
T15558 2302-2309 JJ denotes complex
T15559 2310-2318 VBD denotes resulted
T15560 2319-2321 IN denotes in
T15561 2322-2323 DT denotes a
T15562 2324-2332 NN denotes decrease
T15563 2333-2335 IN denotes of
T15564 2336-2339 DT denotes the
T15565 2340-2346 NN denotes amount
T15566 2347-2349 IN denotes of
T15567 2350-2357 JJ denotes natural
T15568 2358-2360 CC denotes or
T15569 2361-2370 JJ denotes inducible
T15570 2371-2375 NNP denotes Treg
T15571 2376-2377 -LRB- denotes (
T15572 2377-2381 NNP denotes CD25
T15573 2381-2382 NNP denotes +
T15574 2383-2386 CC denotes and
T15575 2387-2392 NNP denotes Foxp3
T15576 2392-2393 NNP denotes +
T15577 2393-2394 -RRB- denotes )
T15578 2395-2400 NNS denotes cells
T15579 2401-2402 CD denotes 7
T15580 2403-2404 LS denotes d
T15581 2405-2410 IN denotes after
T15582 2411-2420 NN denotes treatment
T15583 2420-2421 . denotes .
T15584 2422-2425 PRP$ denotes Our
T15585 2426-2433 NNS denotes results
T15586 2434-2441 VBP denotes suggest
T15587 2442-2446 IN denotes that
T15588 2447-2451 NN denotes IL-4
T15589 2452-2454 VBZ denotes is
T15590 2455-2459 RB denotes only
T15591 2460-2471 VBG denotes interfering
T15592 2472-2476 IN denotes with
T15593 2477-2480 DT denotes the
T15594 2481-2496 NN denotes differentiation
T15595 2497-2499 IN denotes of
T15596 2500-2505 JJ denotes naive
T15597 2506-2507 NNP denotes T
T15598 2508-2513 NNS denotes cells
T15599 2514-2518 IN denotes into
T15600 2519-2524 NNP denotes iTreg
T15601 2525-2530 NNS denotes cells
T15602 2530-2531 . denotes .
T15603 2532-2535 CC denotes But
T15604 2536-2541 IN denotes since
T15605 2542-2543 DT denotes a
T15606 2544-2555 NN denotes distinction
T15607 2556-2558 IN denotes of
T15608 2559-2564 NNP denotes nTreg
T15609 2565-2568 CC denotes and
T15610 2569-2574 NNP denotes iTreg
T15611 2575-2580 NNS denotes cells
T15612 2581-2583 VBZ denotes is
T15613 2584-2593 RB denotes currently
T15614 2594-2597 RB denotes not
T15615 2598-2606 JJ denotes possible
T15616 2606-2607 , denotes ,
T15617 2608-2615 IN denotes because
T15618 2616-2621 NNP denotes iTreg
T15619 2622-2627 NNS denotes cells
T15620 2628-2632 RB denotes also
T15621 2633-2644 RB denotes transiently
T15622 2645-2652 JJ denotes express
T15623 2653-2657 NNS denotes CD25
T15624 2658-2663 IN denotes after
T15625 2664-2674 NN denotes activation
T15626 2674-2675 , denotes ,
T15627 2676-2678 PRP denotes we
T15628 2679-2682 MD denotes can
T15629 2682-2685 RB denotes not
T15630 2686-2693 VB denotes exclude
T15631 2694-2698 DT denotes that
T15632 2699-2703 NN denotes IL-4
T15633 2704-2707 MD denotes may
T15634 2708-2712 RB denotes also
T15635 2713-2720 VB denotes inhibit
T15636 2721-2726 JJ denotes Foxp3
T15637 2727-2737 NN denotes expression
T15638 2738-2740 IN denotes in
T15639 2741-2746 NNP denotes nTreg
T15640 2747-2752 NNS denotes cells
T15641 2753-2755 IN denotes in
T15642 2756-2760 NN denotes vivo
T15643 2761-2763 CC denotes or
T15644 2764-2768 IN denotes that
T15645 2769-2779 JJ denotes additional
T15646 2780-2787 NNS denotes effects
T15647 2788-2791 MD denotes may
T15648 2792-2802 VB denotes contribute
T15649 2803-2805 TO denotes to
T15650 2806-2809 DT denotes the
T15651 2810-2818 JJ denotes observed
T15652 2819-2823 NN denotes drop
T15653 2824-2826 IN denotes in
T15654 2827-2832 JJ denotes Foxp3
T15655 2833-2843 NN denotes expression
T15656 2843-2844 . denotes .
T15657 2845-2849 NN denotes IL-4
T15658 2850-2853 VBZ denotes has
T15659 2854-2861 RB denotes already
T15660 2862-2866 VBN denotes been
T15661 2867-2872 VBN denotes shown
T15662 2873-2875 TO denotes to
T15663 2876-2886 RB denotes negatively
T15664 2887-2895 VB denotes regulate
T15665 2896-2899 DT denotes the
T15666 2900-2911 NN denotes development
T15667 2912-2914 IN denotes of
T15668 2915-2920 JJ denotes naive
T15669 2921-2922 NNP denotes T
T15670 2923-2928 NNS denotes cells
T15671 2929-2933 IN denotes into
T15672 2934-2937 CD denotes Th1
T15673 2938-2940 CC denotes or
T15674 2941-2944 DT denotes the
T15675 2945-2950 NNP denotes IL-17
T15676 2951-2960 VBG denotes producing
T15677 2961-2962 NNP denotes T
T15678 2963-2968 NNS denotes cells
T15679 2969-2970 -LRB- denotes (
T15680 2970-2974 NNP denotes Th17
T15681 2974-2975 -RRB- denotes )
T15682 2976-2977 NNP denotes [
T15683 2977-2982 CD denotes 46,47
T15684 2982-2983 NNP denotes ]
T15685 2983-2984 . denotes .
T15686 2985-2992 JJ denotes Similar
T15687 2993-3000 NNS denotes effects
T15688 3001-3005 VBP denotes have
T15689 3006-3010 VBN denotes been
T15690 3011-3019 RB denotes recently
T15691 3020-3029 VBN denotes described
T15692 3030-3033 IN denotes for
T15693 3034-3038 NNP denotes IL-6
T15694 3038-3039 , denotes ,
T15695 3040-3045 WDT denotes which
T15696 3045-3046 , denotes ,
T15697 3047-3055 VBN denotes combined
T15698 3056-3060 IN denotes with
T15699 3061-3066 NNP denotes TGF-β
T15700 3066-3067 , denotes ,
T15701 3068-3076 VBZ denotes inhibits
T15702 3077-3080 DT denotes the
T15703 3081-3091 NN denotes generation
T15704 3092-3094 IN denotes of
T15705 3095-3100 NNP denotes iTreg
T15706 3101-3106 NNS denotes cells
T15707 3107-3110 CC denotes and
T15708 3111-3118 VBZ denotes induces
T15709 3119-3134 NN denotes differentiation
T15710 3135-3139 IN denotes into
T15711 3140-3143 DT denotes the
T15712 3144-3148 NNP denotes Th17
T15713 3149-3154 NNS denotes cells
T15714 3155-3157 IN denotes by
T15715 3158-3160 DT denotes an
T15716 3161-3168 JJ denotes unknown
T15717 3169-3178 NN denotes mechanism
T15718 3179-3180 NNP denotes [
T15719 3180-3185 CD denotes 48,49
T15720 3185-3186 NNP denotes ]
T15721 3186-3187 . denotes .
T15722 3188-3192 RB denotes Thus
T15723 3193-3196 DT denotes the
T15724 3197-3209 NN denotes polarization
T15725 3210-3214 IN denotes into
T15726 3215-3220 NNP denotes iTreg
T15727 3221-3226 NNS denotes cells
T15728 3227-3229 VBZ denotes is
T15729 3230-3240 RB denotes negatively
T15730 3241-3250 VBN denotes regulated
T15731 3251-3253 IN denotes by
T15732 3254-3257 DT denotes the
T15733 3258-3266 NN denotes effector
T15734 3267-3276 VBZ denotes cytokines
T15735 3277-3281 NN denotes IL-4
T15736 3282-3285 CC denotes and
T15737 3286-3290 NN denotes IL-6
T15738 3290-3291 . denotes .
T15739 3292-3296 NN denotes IL-4
T15740 3297-3300 VBZ denotes has
T15741 3301-3305 VBN denotes been
T15742 3306-3316 RB denotes previously
T15743 3317-3322 VBN denotes shown
T15744 3323-3325 TO denotes to
T15745 3326-3332 VB denotes induce
T15746 3333-3336 DT denotes the
T15747 3337-3347 NN denotes generation
T15748 3348-3350 IN denotes of
T15749 3351-3356 CD denotes FOXP3
T15750 3356-3357 CD denotes +
T15751 3358-3362 NNP denotes Treg
T15752 3363-3368 NNS denotes cells
T15753 3369-3372 IN denotes out
T15754 3373-3375 IN denotes of
T15755 3376-3379 NNP denotes CD4
T15756 3379-3380 NNP denotes +
T15757 3380-3384 NNP denotes CD25
T15758 3386-3387 NNP denotes [
T15759 3387-3389 CD denotes 50
T15760 3389-3390 NNP denotes ]
T15761 3390-3391 . denotes .
T15762 3392-3394 IN denotes In
T15763 3395-3400 DT denotes those
T15764 3401-3412 NNS denotes experiments
T15765 3412-3413 , denotes ,
T15766 3414-3417 DT denotes the
T15767 3418-3432 NNS denotes concentrations
T15768 3433-3435 IN denotes of
T15769 3436-3440 NN denotes IL-4
T15770 3441-3445 VBN denotes used
T15771 3446-3450 VBD denotes were
T15772 3451-3454 JJ denotes low
T15773 3454-3455 , denotes ,
T15774 3456-3459 CC denotes and
T15775 3460-3462 IN denotes as
T15776 3463-3465 PRP denotes we
T15777 3466-3470 RB denotes also
T15778 3471-3479 VBD denotes observed
T15779 3479-3480 , denotes ,
T15780 3481-3485 NN denotes IL-4
T15781 3486-3488 IN denotes at
T15782 3489-3492 JJ denotes low
T15783 3493-3506 NN denotes concentration
T15784 3507-3515 RB denotes slightly
T15785 3516-3524 JJ denotes enhanced
T15786 3525-3530 CD denotes FOXP3
T15787 3531-3541 NN denotes expression
T15788 3541-3542 . denotes .
T15789 3543-3554 RB denotes Importantly
T15790 3554-3555 , denotes ,
T15791 3556-3561 DT denotes these
T15792 3562-3576 NNS denotes concentrations
T15793 3577-3581 VBD denotes were
T15794 3582-3585 RB denotes not
T15795 3586-3596 JJ denotes sufficient
T15796 3597-3599 TO denotes to
T15797 3600-3606 VB denotes induce
T15798 3607-3612 NNP denotes GATA3
T15799 3613-3623 NN denotes expression
T15800 3623-3624 . denotes .
T15801 3625-3629 NN denotes IL-4
T15802 3630-3633 MD denotes may
T15803 3634-3639 VB denotes favor
T15804 3640-3653 NN denotes proliferation
T15805 3654-3656 IN denotes of
T15806 3657-3662 NNP denotes nTreg
T15807 3663-3668 NNS denotes cells
T15808 3669-3670 NNP denotes [
T15809 3670-3672 CD denotes 47
T15810 3672-3673 NNP denotes ]
T15811 3674-3676 CC denotes or
T15812 3677-3685 RB denotes directly
T15813 3686-3694 VB denotes regulate
T15814 3695-3700 CD denotes FOXP3
T15815 3701-3711 NN denotes expression
T15816 3712-3714 IN denotes in
T15817 3715-3716 DT denotes a
T15818 3717-3731 JJ denotes STAT-dependent
T15819 3732-3739 NN denotes fashion
T15820 3740-3741 NNP denotes [
T15821 3741-3743 CD denotes 51
T15822 3743-3744 NNP denotes ]
T15823 3744-3745 . denotes .
T15824 3746-3751 IN denotes Since
T15825 3752-3757 NN denotes IL-13
T15826 3758-3762 VBZ denotes does
T15827 3763-3766 RB denotes not
T15828 3767-3778 RB denotes effectively
T15829 3779-3785 VB denotes reduce
T15830 3786-3791 CD denotes FOXP3
T15831 3792-3795 CC denotes and
T15832 3796-3801 VBZ denotes fails
T15833 3802-3804 TO denotes to
T15834 3805-3811 VB denotes induce
T15835 3812-3817 NNP denotes GATA3
T15836 3817-3818 , denotes ,
T15837 3819-3821 PRP denotes we
T15838 3822-3834 VBD denotes hypothesized
T15839 3835-3839 IN denotes that
T15840 3840-3843 DT denotes the
T15841 3844-3848 NN denotes IL-4
T15842 3849-3858 JJ denotes dependent
T15843 3859-3869 NN denotes inhibition
T15844 3870-3872 IN denotes of
T15845 3873-3878 CD denotes FOXP3
T15846 3879-3884 MD denotes could
T15847 3885-3887 VB denotes be
T15848 3888-3896 VBN denotes mediated
T15849 3897-3899 IN denotes by
T15850 3900-3905 NNP denotes GATA3
T15851 3905-3906 . denotes .
T15852 3907-3909 IN denotes In
T15853 3910-3914 NN denotes fact
T15854 3914-3915 , denotes ,
T15855 3916-3930 VBG denotes GATA3-inducing
T15856 3931-3935 NN denotes IL-4
T15857 3936-3950 NNS denotes concentrations
T15858 3951-3960 VBD denotes repressed
T15859 3961-3966 NNP denotes TGF-β
T15860 3967-3975 VBD denotes mediated
T15861 3976-3981 CD denotes FOXP3
T15862 3982-3992 NN denotes expression
T15863 3992-3993 , denotes ,
T15864 3994-4001 IN denotes whereas
T15865 4002-4006 NN denotes IL-4
T15866 4007-4009 RB denotes as
T15867 4010-4014 RB denotes well
T15868 4015-4017 IN denotes as
T15869 4018-4023 JJ denotes TGF-β
T15870 4024-4033 VBG denotes signaling
T15871 4034-4038 VBD denotes were
T15872 4039-4045 JJ denotes intact
T15873 4045-4046 . denotes .
T15874 4047-4051 DT denotes This
T15875 4052-4058 NN denotes result
T15876 4059-4068 VBD denotes suggested
T15877 4069-4070 DT denotes a
T15878 4071-4082 JJ denotes competitive
T15879 4083-4092 NN denotes mechanism
T15880 4093-4100 IN denotes between
T15881 4101-4106 NNP denotes GATA3
T15882 4107-4110 CC denotes and
T15883 4111-4116 NNP denotes FOXP3
T15884 4117-4130 NN denotes transcription
T15885 4131-4138 NNS denotes factors
T15886 4139-4141 IN denotes in
T15887 4142-4153 VBG denotes determining
T15888 4154-4161 NN denotes lineage
T15889 4162-4172 NN denotes commitment
T15890 4173-4179 IN denotes during
T15891 4180-4183 DT denotes the
T15892 4184-4189 JJ denotes early
T15893 4190-4195 NN denotes phase
T15894 4196-4198 IN denotes of
T15895 4199-4214 NN denotes differentiation
T15896 4214-4215 . denotes .
T15897 4216-4227 RB denotes Accordingly
T15898 4227-4228 , denotes ,
T15899 4229-4231 PRP denotes we
T15900 4232-4244 VBD denotes investigated
T15901 4245-4254 RB denotes naturally
T15902 4255-4259 JJ denotes high
T15903 4260-4276 JJ denotes GATA3-expressing
T15904 4277-4282 NNS denotes cells
T15905 4283-4286 CC denotes and
T15906 4287-4296 VBD denotes confirmed
T15907 4297-4300 DT denotes the
T15908 4301-4308 NN denotes absence
T15909 4309-4311 IN denotes of
T15910 4312-4317 CD denotes FOXP3
T15911 4317-4318 . denotes .
T15912 4319-4326 NN denotes Protein
T15913 4327-4339 NN denotes transduction
T15914 4340-4342 IN denotes of
T15915 4343-4348 CD denotes GATA3
T15916 4349-4353 IN denotes into
T15917 4354-4359 JJ denotes naive
T15918 4360-4361 NNP denotes T
T15919 4362-4367 NNS denotes cells
T15920 4368-4377 VBD denotes inhibited
T15921 4378-4383 CD denotes FOXP3
T15922 4384-4393 NN denotes induction
T15923 4394-4396 IN denotes in
T15924 4397-4402 JJ denotes human
T15925 4402-4403 , denotes ,
T15926 4404-4419 JJ denotes differentiating
T15927 4419-4420 , denotes ,
T15928 4421-4426 JJ denotes naive
T15929 4427-4428 NNP denotes T
T15930 4429-4434 NNS denotes cells
T15931 4434-4435 . denotes .
T15932 4436-4440 DT denotes This
T15933 4441-4451 JJ denotes inhibitory
T15934 4452-4458 NN denotes effect
T15935 4459-4461 IN denotes of
T15936 4462-4467 NNP denotes GATA3
T15937 4468-4471 VBD denotes was
T15938 4472-4479 JJ denotes further
T15939 4480-4489 VBN denotes confirmed
T15940 4490-4492 IN denotes in
T15941 4493-4499 NNP denotes BALB/c
T15942 4500-4510 JJ denotes transgenic
T15943 4511-4515 NNS denotes mice
T15944 4515-4516 , denotes ,
T15945 4517-4527 VBG denotes expressing
T15946 4528-4533 NNP denotes GATA3
T15947 4534-4536 IN denotes in
T15948 4537-4538 NNP denotes T
T15949 4539-4544 NNS denotes cells
T15950 4545-4546 -LRB- denotes (
T15951 4546-4550 CD denotes DO11
T15952 4550-4553 CD denotes .10
T15953 4553-4554 : denotes :
T15954 4554-4563 JJ denotes CD2-GATA3
T15955 4564-4574 JJ denotes transgenic
T15956 4575-4579 NNS denotes mice
T15957 4579-4580 -RRB- denotes )
T15958 4580-4581 . denotes .
T15959 4582-4584 IN denotes In
T15960 4585-4589 NN denotes line
T15961 4590-4594 IN denotes with
T15962 4595-4598 DT denotes the
T15963 4599-4608 NN denotes transient
T15964 4609-4623 NN denotes overexpression
T15965 4624-4626 IN denotes of
T15966 4627-4632 NNP denotes GATA3
T15967 4633-4635 IN denotes in
T15968 4636-4641 JJ denotes human
T15969 4642-4643 NNP denotes T
T15970 4644-4649 NNS denotes cells
T15971 4649-4650 , denotes ,
T15972 4651-4656 NNS denotes cells
T15973 4657-4659 IN denotes of
T15974 4660-4665 DT denotes these
T15975 4666-4670 NNS denotes mice
T15976 4671-4677 VBD denotes failed
T15977 4678-4680 TO denotes to
T15978 4681-4687 VB denotes induce
T15979 4688-4693 CD denotes FOXP3
T15980 4694-4704 NN denotes expression
T15981 4705-4709 IN denotes upon
T15982 4710-4718 NN denotes exposure
T15983 4719-4723 IN denotes with
T15984 4724-4731 NN denotes antigen
T15985 4732-4734 IN denotes in
T15986 4735-4738 DT denotes the
T15987 4739-4747 NN denotes presence
T15988 4748-4750 IN denotes of
T15989 4751-4756 NNP denotes TGF-β
T15990 4756-4757 . denotes .
T15991 4758-4768 RB denotes Strikingly
T15992 4768-4769 , denotes ,
T15993 4770-4773 DT denotes the
T15994 4774-4778 NNP denotes DO11
T15995 4778-4781 CD denotes .10
T15996 4781-4782 : denotes :
T15997 4782-4791 JJ denotes CD2-GATA3
T15998 4792-4796 NNS denotes mice
T15999 4797-4799 VBP denotes do
T16000 4800-4804 VB denotes have
T16001 4805-4815 JJ denotes peripheral
T16002 4816-4821 CD denotes FOXP3
T16003 4821-4822 NN denotes +
T16004 4823-4828 NNS denotes cells
T16005 4828-4829 , denotes ,
T16006 4830-4835 WDT denotes which
T16007 4836-4843 RB denotes however
T16008 4844-4853 VBD denotes displayed
T16009 4854-4855 DT denotes a
T16010 4856-4858 CD denotes 10
T16011 4858-4859 NN denotes %
T16012 4860-4862 CD denotes 25
T16013 4862-4863 NN denotes %
T16014 4864-4869 JJR denotes lower
T16015 4870-4879 NN denotes frequency
T16016 4880-4888 VBN denotes compared
T16017 4889-4891 TO denotes to
T16018 4892-4901 JJ denotes wild-type
T16019 4902-4906 NNP denotes DO11
T16020 4906-4909 CD denotes .10
T16021 4910-4914 NNS denotes mice
T16022 4914-4915 . denotes .
T16023 4916-4920 RB denotes Thus
T16024 4921-4926 JJ denotes GATA3
T16025 4927-4936 NNS denotes restrains
T16026 4937-4940 DT denotes the
T16027 4941-4952 NN denotes development
T16028 4953-4955 IN denotes of
T16029 4956-4963 JJ denotes certain
T16030 4964-4968 NNP denotes Treg
T16031 4969-4976 NNS denotes subsets
T16032 4976-4977 , denotes ,
T16033 4978-4988 RB denotes presumably
T16034 4989-4992 DT denotes the
T16035 4993-5002 JJ denotes inducible
T16036 5002-5003 , denotes ,
T16037 5004-5014 JJ denotes peripheral
T16038 5015-5025 NN denotes population
T16039 5026-5029 CC denotes and
T16040 5030-5033 RB denotes not
T16041 5034-5039 DT denotes those
T16042 5040-5042 IN denotes of
T16043 5043-5049 JJ denotes thymic
T16044 5050-5056 NN denotes origin
T16045 5056-5057 . denotes .
T16046 5058-5064 NNP denotes Thymic
T16047 5065-5066 NNP denotes T
T16048 5067-5072 NNS denotes cells
T16049 5073-5080 VBP denotes undergo
T16050 5081-5082 DT denotes a
T16051 5083-5092 JJ denotes different
T16052 5093-5103 NN denotes maturation
T16053 5104-5111 NN denotes process
T16054 5111-5112 , denotes ,
T16055 5113-5118 WDT denotes which
T16056 5119-5122 MD denotes may
T16057 5123-5130 VB denotes explain
T16058 5131-5134 DT denotes the
T16059 5135-5148 NN denotes insensitivity
T16060 5149-5151 IN denotes of
T16061 5152-5157 NNP denotes nTreg
T16062 5158-5160 TO denotes to
T16063 5161-5166 NNP denotes GATA3
T16064 5167-5181 NN denotes overexpression
T16065 5182-5183 NNP denotes [
T16066 5183-5185 CD denotes 52
T16067 5185-5186 NNP denotes ]
T16068 5186-5187 . denotes .
T16069 5188-5190 IN denotes In
T16070 5191-5199 NN denotes contrast
T16071 5200-5202 TO denotes to
T16072 5203-5206 DT denotes the
T16073 5207-5226 NN denotes Th2-differentiating
T16074 5227-5230 CC denotes and
T16075 5231-5247 JJ denotes iTreg-inhibiting
T16076 5248-5256 NN denotes function
T16077 5257-5259 IN denotes of
T16078 5260-5265 NNP denotes GATA3
T16079 5266-5268 IN denotes in
T16080 5269-5279 JJ denotes peripheral
T16081 5280-5281 NNP denotes T
T16082 5282-5287 NNS denotes cells
T16083 5287-5288 , denotes ,
T16084 5289-5294 JJ denotes GATA3
T16085 5295-5299 NNS denotes acts
T16086 5300-5302 IN denotes in
T16087 5303-5306 DT denotes the
T16088 5307-5313 NN denotes thymus
T16089 5314-5322 RB denotes together
T16090 5323-5327 IN denotes with
T16091 5328-5333 JJ denotes other
T16092 5334-5347 NN denotes transcription
T16093 5348-5355 NNS denotes factors
T16094 5356-5360 JJ denotes such
T16095 5361-5363 IN denotes as
T16096 5364-5367 DT denotes the
T16097 5368-5377 NNP denotes Repressor
T16098 5378-5380 IN denotes of
T16099 5381-5386 NNP denotes GATA3
T16100 5387-5388 -LRB- denotes (
T16101 5388-5391 NNP denotes ROG
T16102 5391-5392 -RRB- denotes )
T16103 5393-5395 IN denotes in
T16104 5396-5399 DT denotes the
T16105 5400-5415 NN denotes differentiation
T16106 5416-5423 NN denotes process
T16107 5424-5430 IN denotes toward
T16108 5431-5434 NNP denotes CD8
T16109 5435-5440 NNS denotes cells
T16110 5441-5442 NNP denotes [
T16111 5442-5447 CD denotes 53,54
T16112 5447-5448 NNP denotes ]
T16113 5449-5451 CC denotes or
T16114 5452-5464 VBZ denotes participates
T16115 5465-5467 IN denotes in
T16116 5468-5475 JJ denotes complex
T16117 5476-5491 JJ denotes transcriptional
T16118 5492-5500 NN denotes feedback
T16119 5501-5508 NN denotes network
T16120 5509-5511 TO denotes to
T16121 5512-5520 VB denotes regulate
T16122 5521-5536 JJ denotes sympathoadrenal
T16123 5537-5552 NN denotes differentiation
T16124 5553-5554 NNP denotes [
T16125 5554-5556 CD denotes 55
T16126 5556-5557 NNP denotes ]
T16127 5557-5558 . denotes .
T16128 5559-5568 RB denotes Therefore
T16129 5568-5569 , denotes ,
T16130 5570-5573 DT denotes the
T16131 5574-5578 NN denotes role
T16132 5579-5581 IN denotes of
T16133 5582-5587 NNP denotes GATA3
T16134 5588-5595 VBZ denotes appears
T16135 5596-5598 TO denotes to
T16136 5599-5601 VB denotes be
T16137 5602-5608 NN denotes tissue
T16138 5609-5617 NN denotes specific
T16139 5618-5621 CC denotes and
T16140 5622-5625 MD denotes can
T16141 5625-5628 RB denotes not
T16142 5629-5631 VB denotes be
T16143 5632-5643 VBN denotes generalized
T16144 5643-5644 . denotes .
T16145 5645-5648 PRP$ denotes Our
T16146 5649-5654 NN denotes study
T16147 5655-5667 VBZ denotes demonstrates
T16148 5668-5672 IN denotes that
T16149 5673-5678 NNP denotes GATA3
T16150 5679-5688 VBD denotes repressed
T16151 5689-5694 CD denotes FOXP3
T16152 5695-5705 NN denotes expression
T16153 5706-5714 RB denotes directly
T16154 5715-5717 IN denotes by
T16155 5718-5725 JJ denotes binding
T16156 5726-5728 TO denotes to
T16157 5729-5732 DT denotes the
T16158 5733-5738 CD denotes FOXP3
T16159 5739-5747 NN denotes promoter
T16160 5748-5754 NN denotes region
T16161 5754-5755 . denotes .
T16162 5756-5757 DT denotes A
T16163 5758-5769 JJ denotes palindromic
T16164 5770-5779 JJ denotes GATA-site
T16165 5780-5782 VBZ denotes is
T16166 5783-5790 VBN denotes located
T16167 5791-5794 CD denotes 303
T16168 5795-5797 NN denotes bp
T16169 5798-5806 RB denotes upstream
T16170 5807-5809 IN denotes of
T16171 5810-5813 DT denotes the
T16172 5814-5817 NNP denotes TSS
T16173 5818-5820 IN denotes in
T16174 5821-5822 DT denotes a
T16175 5823-5829 RB denotes highly
T16176 5830-5839 VBN denotes conserved
T16177 5840-5846 NN denotes region
T16178 5846-5847 , denotes ,
T16179 5848-5853 WDT denotes which
T16180 5854-5856 PRP denotes we
T16181 5857-5861 VBP denotes have
T16182 5862-5872 RB denotes previously
T16183 5873-5883 VBN denotes identified
T16184 5884-5886 IN denotes as
T16185 5887-5890 DT denotes the
T16186 5891-5896 CD denotes FOXP3
T16187 5897-5905 NN denotes promoter
T16188 5906-5907 NNP denotes [
T16189 5907-5909 CD denotes 24
T16190 5909-5910 NNP denotes ]
T16191 5910-5911 . denotes .
T16192 5912-5925 JJ denotes Site-specific
T16193 5926-5934 NN denotes mutation
T16194 5935-5937 IN denotes of
T16195 5938-5942 DT denotes this
T16196 5943-5947 NN denotes site
T16197 5948-5957 VBD denotes increased
T16198 5958-5961 DT denotes the
T16199 5962-5970 NN denotes activity
T16200 5971-5973 IN denotes of
T16201 5974-5977 DT denotes the
T16202 5978-5986 NN denotes promoter
T16203 5987-5997 NNS denotes constructs
T16204 5997-5998 , denotes ,
T16205 5999-6003 RB denotes thus
T16206 6004-6013 VBG denotes revealing
T16207 6014-6017 DT denotes the
T16208 6018-6028 JJ denotes repressive
T16209 6029-6035 NN denotes nature
T16210 6036-6038 IN denotes of
T16211 6039-6043 DT denotes this
T16212 6044-6048 NNP denotes GATA
T16213 6049-6056 NN denotes element
T16214 6057-6059 IN denotes in
T16215 6060-6066 NN denotes memory
T16216 6067-6068 NNP denotes T
T16217 6069-6074 NNS denotes cells
T16218 6074-6075 , denotes ,
T16219 6076-6081 WDT denotes which
T16220 6082-6091 RB denotes naturally
T16221 6092-6099 VBP denotes express
T16222 6100-6105 NNP denotes GATA3
T16223 6105-6106 , denotes ,
T16224 6107-6114 IN denotes whereas
T16225 6115-6117 DT denotes no
T16226 6118-6128 NN denotes difference
T16227 6129-6132 VBD denotes was
T16228 6133-6137 VBN denotes seen
T16229 6138-6140 IN denotes in
T16230 6141-6146 JJ denotes naive
T16231 6147-6148 NNP denotes T
T16232 6149-6154 NNS denotes cells
T16233 6154-6155 , denotes ,
T16234 6156-6161 WDT denotes which
T16235 6162-6164 VBP denotes do
T16236 6165-6168 RB denotes not
T16237 6169-6176 VB denotes express
T16238 6177-6182 NNP denotes GATA3
T16239 6182-6183 . denotes .
T16240 6184-6188 DT denotes This
T16241 6189-6200 JJ denotes palindromic
T16242 6201-6205 NNP denotes GATA
T16243 6206-6213 NN denotes element
T16244 6214-6216 VBZ denotes is
T16245 6217-6222 VBN denotes bound
T16246 6223-6225 IN denotes by
T16247 6226-6231 NNP denotes GATA3
T16248 6232-6239 NN denotes protein
T16249 6240-6242 IN denotes as
T16250 6243-6249 VBN denotes proven
T16251 6250-6254 IN denotes with
T16252 6255-6264 JJ denotes pull-down
T16253 6265-6276 NNS denotes experiments
T16254 6276-6277 . denotes .
T16255 6278-6289 RB denotes Furthermore
T16256 6289-6290 , denotes ,
T16257 6291-6293 PRP denotes it
T16258 6294-6296 VBZ denotes is
T16259 6297-6302 VBN denotes shown
T16260 6303-6305 IN denotes by
T16261 6306-6310 NN denotes ChIP
T16262 6311-6315 IN denotes that
T16263 6316-6321 CD denotes GATA3
T16264 6322-6327 NNS denotes binds
T16265 6328-6332 DT denotes this
T16266 6333-6340 NN denotes element
T16267 6341-6345 RB denotes also
T16268 6346-6348 IN denotes in
T16269 6349-6355 JJ denotes intact
T16270 6356-6361 NNS denotes cells
T16271 6361-6362 . denotes .
T16272 6363-6365 PRP denotes It
T16273 6366-6368 VBZ denotes is
T16274 6369-6374 VBN denotes known
T16275 6375-6379 IN denotes that
T16276 6380-6385 NNP denotes GATA3
T16277 6386-6389 MD denotes can
T16278 6390-6396 VB denotes induce
T16279 6397-6410 NN denotes transcription
T16280 6411-6413 IN denotes by
T16281 6414-6423 NN denotes chromatin
T16282 6424-6434 VBG denotes remodeling
T16283 6435-6436 NNP denotes [
T16284 6436-6438 CD denotes 56
T16285 6438-6439 NNP denotes ]
T16286 6439-6440 , denotes ,
T16287 6441-6443 IN denotes by
T16288 6444-6452 RB denotes directly
T16289 6453-6468 VBG denotes transactivating
T16290 6469-6478 NNS denotes promoters
T16291 6479-6480 NNP denotes [
T16292 6480-6482 CD denotes 36
T16293 6482-6483 NNP denotes ]
T16294 6483-6484 , denotes ,
T16295 6485-6487 CC denotes or
T16296 6487-6488 , denotes ,
T16297 6489-6491 IN denotes as
T16298 6492-6497 VBN denotes shown
T16299 6498-6500 IN denotes in
T16300 6501-6504 DT denotes the
T16301 6505-6512 JJ denotes current
T16302 6513-6518 NN denotes study
T16303 6518-6519 , denotes ,
T16304 6520-6524 VBZ denotes acts
T16305 6525-6527 IN denotes as
T16306 6528-6529 DT denotes a
T16307 6530-6539 NN denotes repressor
T16308 6540-6542 IN denotes of
T16309 6543-6547 NN denotes gene
T16310 6548-6558 NN denotes expression
T16311 6559-6560 NNP denotes [
T16312 6560-6565 CD denotes 21,57
T16313 6566-6568 CD denotes 59
T16314 6568-6569 NN denotes ]
T16315 6569-6570 . denotes .
T16316 6571-6580 RB denotes Therefore
T16317 6581-6588 VBG denotes keeping
T16318 6589-6594 JJ denotes GATA3
T16319 6595-6605 NN denotes expression
T16320 6606-6609 JJ denotes low
T16321 6610-6615 MD denotes might
T16322 6616-6618 VB denotes be
T16323 6619-6627 VBN denotes required
T16324 6628-6630 TO denotes to
T16325 6631-6637 VB denotes induce
T16326 6638-6647 JJ denotes efficient
T16327 6648-6653 CD denotes FOXP3
T16328 6653-6654 CD denotes +
T16329 6655-6660 NNP denotes iTreg
T16330 6661-6665 NN denotes cell
T16331 6666-6676 NN denotes generation
T16332 6676-6677 . denotes .
T16333 6678-6681 DT denotes The
T16334 6682-6691 JJ denotes molecular
T16335 6692-6704 NNS denotes interactions
T16336 6705-6713 VBG denotes enabling
T16337 6714-6719 CD denotes GATA3
T16338 6720-6722 TO denotes to
T16339 6723-6730 VB denotes inhibit
T16340 6731-6736 CD denotes FOXP3
T16341 6737-6740 VBP denotes are
T16342 6741-6744 RB denotes not
T16343 6745-6755 VBN denotes identified
T16344 6756-6759 RB denotes yet
T16345 6759-6760 , denotes ,
T16346 6761-6764 CC denotes but
T16347 6765-6768 DT denotes the
T16348 6769-6781 JJ denotes GATA-binding
T16349 6782-6786 NN denotes site
T16350 6787-6789 VBZ denotes is
T16351 6790-6797 VBN denotes located
T16352 6798-6806 JJ denotes adjacent
T16353 6807-6809 TO denotes to
T16354 6810-6818 JJ denotes positive
T16355 6818-6819 , denotes ,
T16356 6820-6828 VBG denotes inducing
T16357 6829-6834 NNS denotes sites
T16358 6834-6835 , denotes ,
T16359 6836-6844 VBN denotes composed
T16360 6845-6847 IN denotes of
T16361 6848-6859 JJ denotes AP-1-NFATc2
T16362 6860-6865 NNS denotes sites
T16363 6866-6867 NNP denotes [
T16364 6867-6869 CD denotes 24
T16365 6869-6870 NNP denotes ]
T16366 6870-6871 , denotes ,
T16367 6872-6875 CC denotes and
T16368 6876-6881 NNP denotes GATA3
T16369 6882-6885 MD denotes may
T16370 6886-6893 VB denotes compete
T16371 6894-6898 IN denotes with
T16372 6899-6902 DT denotes the
T16373 6903-6910 JJ denotes binding
T16374 6911-6913 IN denotes of
T16375 6914-6918 NNP denotes AP-1
T16376 6918-6919 NNP denotes /
T16377 6919-6923 NNP denotes NFAT
T16378 6924-6926 TO denotes to
T16379 6927-6930 DT denotes the
T16380 6931-6939 NN denotes promoter
T16381 6940-6941 -LRB- denotes (
T16382 6941-6952 JJ denotes unpublished
T16383 6953-6965 NNS denotes observations
T16384 6965-6966 -RRB- denotes )
T16385 6966-6967 . denotes .
T16386 6968-6970 IN denotes In
T16387 6971-6978 NN denotes summary
T16388 6978-6979 , denotes ,
T16389 6980-6982 PRP denotes we
T16390 6983-6995 VBD denotes demonstrated
T16391 6996-7000 IN denotes that
T16392 7001-7006 CD denotes FOXP3
T16393 7007-7009 VBZ denotes is
T16394 7010-7020 RB denotes negatively
T16395 7021-7030 VBN denotes regulated
T16396 7031-7033 IN denotes by
T16397 7034-7043 NNS denotes cytokines
T16398 7044-7048 JJ denotes such
T16399 7049-7051 IN denotes as
T16400 7052-7056 NN denotes IL-4
T16401 7056-7057 . denotes .
T16402 7058-7063 CD denotes GATA3
T16403 7064-7068 NNS denotes acts
T16404 7069-7071 IN denotes as
T16405 7072-7074 DT denotes an
T16406 7075-7084 NN denotes inhibitor
T16407 7085-7087 IN denotes of
T16408 7088-7093 CD denotes FOXP3
T16409 7094-7104 NN denotes expression
T16410 7105-7107 IN denotes in
T16411 7108-7113 JJ denotes early
T16412 7114-7115 NNP denotes T
T16413 7116-7120 NN denotes cell
T16414 7121-7136 NN denotes differentiation
T16415 7136-7137 , denotes ,
T16416 7138-7140 RB denotes as
T16417 7141-7145 RB denotes well
T16418 7146-7148 IN denotes as
T16419 7149-7151 IN denotes in
T16420 7152-7166 JJ denotes differentiated
T16421 7167-7170 JJ denotes Th2
T16422 7171-7176 NNS denotes cells
T16423 7177-7179 IN denotes by
T16424 7180-7188 RB denotes directly
T16425 7189-7196 JJ denotes binding
T16426 7197-7200 CC denotes and
T16427 7201-7211 VBG denotes repressing
T16428 7212-7215 DT denotes the
T16429 7216-7221 CD denotes FOXP3
T16430 7222-7230 NN denotes promoter
T16431 7230-7231 . denotes .
T16432 7232-7234 PRP denotes We
T16433 7235-7244 RB denotes therefore
T16434 7245-7253 VBP denotes describe
T16435 7254-7255 DT denotes a
T16436 7256-7259 JJ denotes new
T16437 7260-7269 NN denotes mechanism
T16438 7270-7272 IN denotes of
T16439 7273-7276 WRB denotes how
T16440 7277-7281 JJ denotes Il-4
T16441 7282-7288 NNS denotes avoids
T16442 7289-7298 NN denotes tolerance
T16443 7299-7308 NN denotes induction
T16444 7309-7311 IN denotes by
T16445 7312-7322 VBG denotes repressing
T16446 7323-7328 CD denotes FOXP3
T16447 7329-7339 NN denotes expression
T16448 7339-7340 . denotes .
T16449 7341-7346 DT denotes These
T16450 7347-7355 NNS denotes findings
T16451 7356-7360 MD denotes will
T16452 7361-7365 VB denotes give
T16453 7366-7369 JJ denotes new
T16454 7370-7382 NNS denotes perspectives
T16455 7383-7389 IN denotes toward
T16456 7390-7403 VBG denotes understanding
T16457 7404-7413 JJ denotes molecular
T16458 7414-7424 NNS denotes mechanisms
T16459 7425-7427 IN denotes of
T16460 7428-7433 NNP denotes iTreg
T16461 7434-7443 NN denotes induction
T16462 7444-7447 CC denotes and
T16463 7448-7452 RB denotes thus
T16464 7453-7461 NNS denotes pathways
T16465 7462-7464 IN denotes of
T16466 7465-7475 JJ denotes peripheral
T16467 7476-7485 NN denotes tolerance
T16468 7486-7495 NN denotes induction
T16469 7495-7496 , denotes ,
T16470 7497-7509 RB denotes particularly
T16471 7510-7512 IN denotes in
T16472 7513-7520 NN denotes allergy
T16473 7521-7524 CC denotes and
T16474 7525-7531 NN denotes asthma
T16475 7531-7532 . denotes .
R11400 T15144 T15146 det The,study
R11401 T15145 T15146 amod current,study
R11402 T15146 T15147 nsubj study,reveals
R11403 T15147 T15147 ROOT reveals,reveals
R11404 T15148 T15160 mark that,inhibited
R11405 T15149 T15150 nummod FOXP3,induction
R11406 T15150 T15160 nsubjpass induction,inhibited
R11407 T15151 T15150 punct ",",induction
R11408 T15152 T15154 det an,step
R11409 T15153 T15154 amod important,step
R11410 T15154 T15150 appos step,induction
R11411 T15155 T15154 prep in,step
R11412 T15156 T15157 compound iTreg,commitment
R11413 T15157 T15155 pobj commitment,in
R11414 T15158 T15160 punct ",",inhibited
R11415 T15159 T15160 auxpass is,inhibited
R11416 T15160 T15147 ccomp inhibited,reveals
R11417 T15161 T15160 agent by,inhibited
R11418 T15162 T15161 pobj GATA3,by
R11419 T15163 T15162 punct ",",GATA3
R11420 T15164 T15165 nsubj which,is
R11421 T15165 T15162 relcl is,GATA3
R11422 T15166 T15168 det the,regulator
R11423 T15167 T15168 amod key,regulator
R11424 T15168 T15165 attr regulator,is
R11425 T15169 T15168 prep for,regulator
R11426 T15170 T15169 pobj polarization,for
R11427 T15171 T15170 prep toward,polarization
R11428 T15172 T15173 amod Th2,cells
R11429 T15173 T15171 pobj cells,toward
R11430 T15174 T15147 punct .,reveals
R11431 T15175 T15182 prep After,become
R11432 T15176 T15175 pobj differentiation,After
R11433 T15177 T15182 punct ",",become
R11434 T15178 T15181 det the,cells
R11435 T15179 T15181 nmod effector,cells
R11436 T15180 T15181 amod Th2,cells
R11437 T15181 T15182 nsubj cells,become
R11438 T15182 T15182 ROOT become,become
R11439 T15183 T15182 acomp refractory,become
R11440 T15184 T15185 aux to,conversion
R11441 T15185 T15182 advcl conversion,become
R11442 T15186 T15185 prep into,conversion
R11443 T15187 T15190 det a,phenotype
R11444 T15188 T15190 nummod FOXP3,phenotype
R11445 T15189 T15190 compound +,phenotype
R11446 T15190 T15186 pobj phenotype,into
R11447 T15191 T15182 punct .,become
R11448 T15192 T15199 prep In,found
R11449 T15193 T15192 pobj accordance,In
R11450 T15194 T15193 prep with,accordance
R11451 T15195 T15196 amod other,studies
R11452 T15196 T15194 pobj studies,with
R11453 T15197 T15199 punct ",",found
R11454 T15198 T15199 nsubj we,found
R11455 T15199 T15199 ROOT found,found
R11456 T15200 T15205 mark that,were
R11457 T15201 T15203 nummod CD4,CD25
R11458 T15202 T15203 nummod +,CD25
R11459 T15203 T15205 nsubj CD25,were
R11460 T15204 T15203 appos cells,CD25
R11461 T15205 T15199 ccomp were,found
R11462 T15206 T15205 acomp able,were
R11463 T15207 T15208 aux to,up-regulate
R11464 T15208 T15206 xcomp up-regulate,able
R11465 T15209 T15212 nummod FOXP3,]
R11466 T15210 T15212 compound [,]
R11467 T15211 T15212 compound "12,27",]
R11468 T15212 T15208 dobj ],up-regulate
R11469 T15213 T15199 punct .,found
R11470 T15214 T15215 amod Already-committed,cells
R11471 T15215 T15224 nsubj cells,showed
R11472 T15216 T15217 amod such,as
R11473 T15217 T15215 prep as,cells
R11474 T15218 T15220 compound memory,cells
R11475 T15219 T15220 compound T,cells
R11476 T15220 T15217 pobj cells,as
R11477 T15221 T15220 cc and,cells
R11478 T15222 T15223 amod Th1,cells
R11479 T15223 T15220 conj cells,cells
R11480 T15224 T15224 ROOT showed,showed
R11481 T15225 T15226 advmod only,moderate
R11482 T15226 T15230 amod moderate,induction
R11483 T15227 T15226 cc and,moderate
R11484 T15228 T15226 conj transient,moderate
R11485 T15229 T15230 nummod FOXP3,induction
R11486 T15230 T15224 dobj induction,showed
R11487 T15231 T15230 punct ",",induction
R11488 T15232 T15233 nsubj which,is
R11489 T15233 T15230 relcl is,induction
R11490 T15234 T15233 neg not,is
R11491 T15235 T15233 acomp sufficient,is
R11492 T15236 T15237 aux to,change
R11493 T15237 T15235 xcomp change,sufficient
R11494 T15238 T15239 det the,phenotype
R11495 T15239 T15237 dobj phenotype,change
R11496 T15240 T15239 prep toward,phenotype
R11497 T15241 T15245 det a,profile
R11498 T15242 T15244 amod regulatory,cell
R11499 T15243 T15244 compound T,cell
R11500 T15244 T15245 compound cell,profile
R11501 T15245 T15240 pobj profile,toward
R11502 T15246 T15224 punct .,showed
R11503 T15247 T15255 prep In,up-regulate
R11504 T15248 T15247 pobj contrast,In
R11505 T15249 T15255 punct ",",up-regulate
R11506 T15250 T15252 amod naive,cells
R11507 T15251 T15252 compound T,cells
R11538 T15282 T15273 cc and,plays
R11539 T15283 T15284 aux may,act
R11540 T15284 T15273 conj act,plays
R11541 T15285 T15284 prep in,act
R11542 T15286 T15287 det a,way
R11543 T15287 T15285 pobj way,in
R11544 T15288 T15287 amod similar,way
R11545 T15289 T15288 prep to,similar
R11546 T15290 T15289 pobj that,to
R11547 T15291 T15290 acl known,that
R11548 T15292 T15291 prep for,known
R11549 T15293 T15296 det the,factors
R11550 T15294 T15295 compound Th1/Th2,decision
R11551 T15295 T15296 compound decision,factors
R11552 T15296 T15292 pobj factors,for
R11553 T15297 T15296 appos T-bet,factors
R11554 T15298 T15297 cc and,T-bet
R11555 T15299 T15297 conj GATA3,T-bet
R11556 T15300 T15255 punct .,up-regulate
R11618 T15362 T15361 cc and,GATA3
R11619 T15363 T15361 conj T-bet,GATA3
R11620 T15364 T15367 amod low,]
R11621 T15365 T15367 compound [,]
R11622 T15366 T15367 compound "37,38",]
R11623 T15367 T15361 appos ],GATA3
R11624 T15368 T15345 punct .,appeared
R11625 T15369 T15393 prep In,showed
R11626 T15370 T15369 pobj contrast,In
R11627 T15371 T15393 punct ",",showed
R11628 T15372 T15393 nsubj differentiating,showed
R11629 T15373 T15375 amod naive,cells
R11630 T15374 T15375 compound T,cells
R11631 T15375 T15372 dobj cells,differentiating
R11632 T15376 T15372 prep in,differentiating
R11633 T15377 T15378 det the,absence
R11634 T15378 T15376 pobj absence,in
R11697 T15441 T15442 nummod 40,]
R11698 T15442 T15442 ROOT ],]
R11699 T15443 T15442 punct ",",]
R11700 T15444 T15442 cc and,]
R11701 T15445 T15452 nsubjpass estrogens,known
R11702 T15446 T15448 nmod [,]
R11703 T15447 T15448 nummod 41,]
R11704 T15448 T15445 dobj ],estrogens
R11705 T15449 T15450 punct ",",are
R11706 T15450 T15452 auxpass are,known
R11707 T15451 T15452 advmod also,known
R11708 T15452 T15452 ROOT known,known
R11709 T15453 T15452 prep as,known
R11710 T15454 T15453 pobj inhibitors,as
R11711 T15455 T15454 prep of,inhibitors
R11712 T15456 T15457 compound GATA3,expression
R11743 T15487 T15486 cc but,IL-4
R11744 T15488 T15489 neg not,IL-13
R11745 T15489 T15494 nsubj IL-13,was
R11746 T15490 T15489 punct (,IL-13
R11747 T15491 T15492 amod unpublished,data
R11748 T15492 T15489 appos data,IL-13
R11749 T15493 T15489 punct ),IL-13
R11750 T15494 T15494 ROOT was,was
R11751 T15495 T15494 acomp able,was
R11752 T15496 T15497 aux to,inhibit
R11753 T15497 T15495 xcomp inhibit,able
R11754 T15498 T15497 dobj TGF-β,inhibit
R11755 T15499 T15494 advcl mediated,was
R11756 T15500 T15501 nummod FOXP3,induction
R11757 T15501 T15499 dobj induction,mediated
R11758 T15502 T15499 cc and,mediated
R11759 T15503 T15504 advmod therefore,prevented
R11760 T15504 T15499 conj prevented,mediated
R11761 T15505 T15504 dobj conversion,prevented
R11762 T15506 T15504 prep into,prevented
R11763 T15507 T15509 det the,phenotype
R11764 T15508 T15509 amod regulatory,phenotype
R11765 T15509 T15506 pobj phenotype,into
R11766 T15510 T15494 punct .,was
R11767 T15511 T15512 aux To,prove
R11768 T15512 T15528 advcl prove,treated
R11769 T15513 T15515 det the,effect
R11770 T15514 T15515 amod inhibitory,effect
R11771 T15515 T15512 dobj effect,prove
R11772 T15516 T15515 prep of,effect
R11773 T15517 T15516 pobj IL-4,of
R11774 T15518 T15517 prep on,IL-4
R11775 T15519 T15523 amod inducible,commitment
R11776 T15520 T15519 cc or,inducible
R11777 T15521 T15519 conj natural,inducible
R11778 T15522 T15523 compound Treg,commitment
R11779 T15523 T15518 pobj commitment,on
R11780 T15524 T15523 prep in,commitment
R11781 T15525 T15524 pobj vivo,in
R11782 T15526 T15528 punct ",",treated
R11783 T15527 T15528 nsubj we,treated
R11784 T15528 T15528 ROOT treated,treated
R11785 T15529 T15528 dobj mice,treated
R11786 T15530 T15528 prep with,treated
R11787 T15531 T15530 pobj IL-4,with
R11788 T15532 T15531 cc and,IL-4
R11789 T15533 T15531 conj anti-IL-4,IL-4
R11790 T15534 T15528 punct .,treated
R11792 T15535 T15538 nsubjpass This,shown
R11794 T15536 T15538 aux has,shown
R11798 T15537 T15538 auxpass been,shown
R11803 T15538 T15538 ROOT shown,shown
R11805 T15539 T15540 aux to,increase
R11808 T15540 T15538 xcomp increase,shown
R11812 T15541 T15542 det the,effect
R11819 T15542 T15540 dobj effect,increase
R11823 T15543 T15542 prep of,effect
R11827 T15544 T15545 det the,cytokine
R11830 T15545 T15543 pobj cytokine,of
R11836 T15546 T15545 prep in,cytokine
R11840 T15547 T15546 pobj vivo,in
R11845 T15548 T15550 nmod [,]
R11846 T15549 T15550 nummod 19,]
R11849 T15550 T15550 ROOT ],]
R11854 T15551 T15538 punct .,shown
R11856 T15552 T15559 advmod Only,resulted
R11857 T15553 T15558 det the,complex
R11860 T15554 T15556 compound IL-4,IL-4
R11863 T15555 T15556 compound /,IL-4
R11872 T15556 T15558 compound IL-4,complex
R11877 T15557 T15558 compound mAb,complex
R11882 T15558 T15559 nsubj complex,resulted
R11886 T15676 T15675 appos producing,IL-17
R11887 T15559 T15559 ROOT resulted,resulted
R11888 T15677 T15678 compound T,cells
R11889 T15678 T15676 dobj cells,producing
R11890 T15679 T15680 punct (,Th17
R11891 T15680 T15678 appos Th17,cells
R11892 T15560 T15559 prep in,resulted
R11893 T15681 T15675 punct ),IL-17
R11894 T15682 T15684 compound [,]
R11895 T15683 T15684 compound "46,47",]
R11896 T15561 T15562 det a,decrease
R11897 T15684 T15684 ROOT ],]
R11898 T15685 T15684 punct .,]
R11899 T15686 T15687 amod Similar,effects
R11900 T15562 T15560 pobj decrease,in
R11901 T15687 T15691 nsubjpass effects,described
R11902 T15688 T15691 aux have,described
R11903 T15689 T15691 auxpass been,described
R11904 T15563 T15562 prep of,decrease
R11905 T15690 T15691 advmod recently,described
R11906 T15691 T15691 ROOT described,described
R11907 T15692 T15691 prep for,described
R11908 T15564 T15565 det the,amount
R11909 T15693 T15692 pobj IL-6,for
R11910 T15565 T15563 pobj amount,of
R11913 T15566 T15565 prep of,amount
R11955 T15725 T15724 prep into,polarization
R11957 T15726 T15727 compound iTreg,cells
R11958 T15727 T15725 pobj cells,into
R11960 T15728 T15730 auxpass is,regulated
R11961 T15729 T15730 advmod negatively,regulated
R11962 T15730 T15730 ROOT regulated,regulated
R11964 T15731 T15730 agent by,regulated
R11965 T15732 T15735 det the,IL-4
R11966 T15733 T15734 compound effector,cytokines
R11967 T15734 T15735 compound cytokines,IL-4
R11968 T15735 T15731 pobj IL-4,by
R11969 T15736 T15735 cc and,IL-4
R11971 T15737 T15735 conj IL-6,IL-4
R11972 T15738 T15730 punct .,regulated
R11973 T15739 T15743 nsubjpass IL-4,shown
R11975 T15740 T15743 aux has,shown
R11976 T15741 T15743 auxpass been,shown
R11977 T15742 T15743 advmod previously,shown
R11979 T15743 T15743 ROOT shown,shown
R11980 T15744 T15745 aux to,induce
R11981 T15745 T15743 xcomp induce,shown
R11983 T15746 T15747 det the,generation
R11984 T15747 T15745 dobj generation,induce
R11985 T15748 T15747 prep of,generation
R11987 T15749 T15752 nummod FOXP3,cells
R11988 T15750 T15752 nummod +,cells
R11989 T15751 T15752 compound Treg,cells
R11991 T15752 T15748 pobj cells,of
R11992 T15753 T15745 prep out,induce
R11993 T15754 T15753 prep of,out
R11994 T15588 T15591 nsubj IL-4,interfering
R11995 T15755 T15757 compound CD4,CD25
R11996 T15756 T15757 compound +,CD25
R11997 T15757 T15754 pobj CD25,of
R11998 T15758 T15760 nmod [,]
R11999 T15589 T15591 aux is,interfering
R12000 T15759 T15760 nummod 50,]
R12001 T15760 T15760 ROOT ],]
R12002 T15761 T15743 punct .,shown
R12003 T15762 T15771 prep In,were
R12004 T15590 T15591 advmod only,interfering
R12005 T15763 T15764 det those,experiments
R12006 T15764 T15762 pobj experiments,In
R12007 T15765 T15771 punct ",",were
R12008 T15766 T15767 det the,concentrations
R12009 T15591 T15586 ccomp interfering,suggest
R12010 T15767 T15771 nsubj concentrations,were
R12011 T15768 T15767 prep of,concentrations
R12012 T15769 T15768 pobj IL-4,of
R12013 T15592 T15591 prep with,interfering
R12014 T15770 T15767 acl used,concentrations
R12015 T15771 T15771 ROOT were,were
R12016 T15772 T15771 acomp low,were
R12017 T15593 T15594 det the,differentiation
R12018 T15773 T15771 punct ",",were
R12019 T15594 T15592 pobj differentiation,with
R12020 T15774 T15771 cc and,were
R12021 T15775 T15778 mark as,observed
R12022 T15776 T15778 nsubj we,observed
R12023 T15595 T15594 prep of,differentiation
R12024 T15777 T15778 advmod also,observed
R12025 T15778 T15771 conj observed,were
R12026 T15779 T15778 punct ",",observed
R12027 T15780 T15778 npadvmod IL-4,observed
R12028 T15596 T15598 amod naive,cells
R12029 T15781 T15778 prep at,observed
R12030 T15782 T15783 amod low,concentration
R12031 T15783 T15781 pobj concentration,at
R12032 T15597 T15598 compound T,cells
R12033 T15784 T15785 advmod slightly,enhanced
R12034 T15785 T15787 amod enhanced,expression
R12035 T15786 T15787 nummod FOXP3,expression
R12036 T15598 T15595 pobj cells,of
R12037 T15787 T15778 npadvmod expression,observed
R12038 T15788 T15771 punct .,were
R12039 T15599 T15594 prep into,differentiation
R12040 T15789 T15793 advmod Importantly,were
R12041 T15790 T15793 punct ",",were
R12042 T15791 T15792 det these,concentrations
R12043 T15600 T15601 compound iTreg,cells
R12044 T15792 T15793 nsubj concentrations,were
R12045 T15793 T15793 ROOT were,were
R12046 T15794 T15793 neg not,were
R12047 T15601 T15599 pobj cells,into
R12048 T15795 T15793 acomp sufficient,were
R12049 T15796 T15797 aux to,induce
R12050 T15797 T15795 xcomp induce,sufficient
R12051 T15602 T15586 punct .,suggest
R12052 T15798 T15799 compound GATA3,expression
R12053 T15603 T15630 cc But,exclude
R12054 T15604 T15630 prep since,exclude
R12056 T15799 T15797 dobj expression,induce
R12057 T15800 T15793 punct .,were
R12058 T15801 T15803 nsubj IL-4,favor
R12059 T15802 T15803 aux may,favor
R12061 T15803 T15803 ROOT favor,favor
R12063 T15804 T15803 dobj proliferation,favor
R12064 T15805 T15804 prep of,proliferation
R12066 T15806 T15807 compound nTreg,cells
R12067 T15807 T15805 pobj cells,of
R12068 T15808 T15813 nsubj [,regulate
R12069 T15809 T15810 nummod 47,]
R12070 T15810 T15813 nsubj ],regulate
R12071 T15811 T15810 cc or,]
R12073 T15812 T15813 advmod directly,regulate
R12074 T15813 T15803 conj regulate,favor
R12075 T15814 T15815 nummod FOXP3,expression
R12077 T15815 T15813 dobj expression,regulate
R12078 T15816 T15813 prep in,regulate
R12079 T15817 T15819 det a,fashion
R12081 T15818 T15819 amod STAT-dependent,fashion
R12082 T15819 T15816 pobj fashion,in
R12083 T15820 T15822 nmod [,]
R12085 T15821 T15822 nummod 51,]
R12086 T15822 T15813 npadvmod ],regulate
R12087 T15823 T15813 punct .,regulate
R12089 T15824 T15829 mark Since,reduce
R12090 T15825 T15829 nsubj IL-13,reduce
R12091 T15826 T15829 aux does,reduce
R12093 T15827 T15829 neg not,reduce
R12094 T15828 T15829 advmod effectively,reduce
R12095 T15829 T15838 advcl reduce,hypothesized
R12097 T15830 T15829 dobj FOXP3,reduce
R12098 T15831 T15829 cc and,reduce
R12099 T15832 T15829 conj fails,reduce
R12101 T15833 T15834 aux to,induce
R12102 T15834 T15832 xcomp induce,fails
R12103 T15835 T15834 dobj GATA3,induce
R12104 T15836 T15838 punct ",",hypothesized
R12106 T15837 T15838 nsubj we,hypothesized
R12107 T15838 T15838 ROOT hypothesized,hypothesized
R12108 T15839 T15848 mark that,mediated
R12110 T15840 T15841 det the,IL-4
R12111 T15841 T15848 nsubjpass IL-4,mediated
R12112 T15842 T15843 amod dependent,inhibition
R12114 T15843 T15841 appos inhibition,IL-4
R12115 T15844 T15843 prep of,inhibition
R12116 T15845 T15844 pobj FOXP3,of
R12117 T15846 T15848 aux could,mediated
R12118 T15847 T15848 auxpass be,mediated
R12119 T15848 T15838 ccomp mediated,hypothesized
R12121 T15849 T15848 agent by,mediated
R12168 T15917 T15919 amod naive,cells
R12169 T15882 T15881 cc and,GATA3
R12170 T15883 T15881 conj FOXP3,GATA3
R12171 T15884 T15885 compound transcription,factors
R12172 T15918 T15919 compound T,cells
R12173 T15885 T15879 conj factors,mechanism
R12174 T15886 T15876 prep in,suggested
R12175 T15919 T15916 pobj cells,into
R12176 T15920 T15920 ROOT inhibited,inhibited
R12177 T15921 T15922 nummod FOXP3,induction
R12178 T15922 T15920 dobj induction,inhibited
R12179 T15923 T15922 prep in,induction
R12183 T15924 T15930 amod human,cells
R12187 T15925 T15924 punct ",",human
R12191 T15926 T15924 conj differentiating,human
R12195 T15927 T15930 punct ",",cells
R12196 T15928 T15930 amod naive,cells
R12197 T15929 T15930 compound T,cells
R12200 T15930 T15923 pobj cells,in
R12203 T15931 T15920 punct .,inhibited
R12207 T15932 T15934 det This,effect
R12211 T15933 T15934 amod inhibitory,effect
R12214 T15934 T15939 nsubjpass effect,confirmed
R12215 T15935 T15934 prep of,effect
R12216 T16007 T16008 advmod however,displayed
R12217 T15936 T15935 pobj GATA3,of
R12218 T16008 T16004 relcl displayed,cells
R12219 T16009 T16011 det a,%
R12220 T16010 T16011 nummod 10,%
R12221 T16011 T16008 dobj %,displayed
R12222 T16012 T16013 nummod 25,%
R12223 T16013 T16014 npadvmod %,lower
R12224 T16014 T16015 amod lower,frequency
R12225 T15937 T15939 auxpass was,confirmed
R12226 T16015 T16008 npadvmod frequency,displayed
R12227 T16016 T16008 prep compared,displayed
R12228 T16017 T16016 prep to,compared
R12229 T15938 T15939 advmod further,confirmed
R12230 T16018 T16021 amod wild-type,mice
R12231 T16019 T16021 nmod DO11,mice
R12232 T16020 T16021 nummod .10,mice
R12233 T15939 T15939 ROOT confirmed,confirmed
R12234 T16021 T16017 pobj mice,to
R12235 T16022 T16000 punct .,have
R12236 T16023 T16025 advmod Thus,restrains
R12237 T15940 T15939 prep in,confirmed
R12238 T16024 T16025 nsubj GATA3,restrains
R12239 T16025 T16025 ROOT restrains,restrains
R12240 T16026 T16027 det the,development
R12241 T15941 T15943 nmod BALB/c,mice
R12242 T16027 T16025 dobj development,restrains
R12243 T16028 T16027 prep of,development
R12244 T16029 T16031 amod certain,subsets
R12245 T15942 T15943 amod transgenic,mice
R12246 T16030 T16031 compound Treg,subsets
R12247 T16031 T16028 pobj subsets,of
R12248 T15943 T15940 pobj mice,in
R12249 T16032 T16031 punct ",",subsets
R12250 T16033 T16038 advmod presumably,population
R12251 T16034 T16038 det the,population
R12252 T15944 T15939 punct ",",confirmed
R12253 T16035 T16038 amod inducible,population
R12254 T16036 T16038 punct ",",population
R12255 T16037 T16038 amod peripheral,population
R12256 T15945 T15939 advcl expressing,confirmed
R12257 T16038 T16031 conj population,subsets
R12258 T16039 T16038 cc and,population
R12259 T16040 T16041 neg not,those
R12260 T15946 T15945 dobj GATA3,expressing
R12261 T15947 T15945 prep in,expressing
R12262 T16041 T16038 conj those,population
R12263 T16042 T16041 prep of,those
R12264 T15948 T15949 compound T,cells
R12265 T16043 T16044 amod thymic,origin
R12266 T16044 T16042 pobj origin,of
R12267 T15949 T15947 pobj cells,in
R12268 T16045 T16025 punct .,restrains
R12269 T16046 T16048 compound Thymic,cells
R12270 T16047 T16048 compound T,cells
R12271 T16048 T16049 nsubj cells,undergo
R12272 T16049 T16049 ROOT undergo,undergo
R12273 T15950 T15951 punct (,DO11
R12274 T16050 T16053 det a,process
R12275 T16051 T16053 amod different,process
R12276 T15951 T15956 nummod DO11,mice
R12277 T16052 T16053 compound maturation,process
R12278 T15952 T15956 nummod .10,mice
R12279 T16053 T16049 dobj process,undergo
R12280 T16054 T16053 punct ",",process
R12281 T16055 T16057 nsubj which,explain
R12282 T15953 T15956 punct :,mice
R12283 T16056 T16057 aux may,explain
R12284 T16057 T16053 relcl explain,process
R12285 T15954 T15956 amod CD2-GATA3,mice
R12286 T16058 T16059 det the,insensitivity
R12287 T16059 T16057 dobj insensitivity,explain
R12288 T16060 T16059 prep of,insensitivity
R12289 T15955 T15956 amod transgenic,mice
R12290 T16061 T16060 pobj nTreg,of
R12291 T16062 T16059 prep to,insensitivity
R12292 T16063 T16065 compound GATA3,[
R12293 T16064 T16065 compound overexpression,[
R12294 T15956 T15945 conj mice,expressing
R12295 T16065 T16062 pobj [,to
R12296 T16066 T16067 nummod 52,]
R12297 T16067 T16065 appos ],[
R12298 T15957 T15939 punct ),confirmed
R12299 T16068 T16049 punct .,undergo
R12300 T16069 T16069 ROOT In,In
R12301 T16070 T16069 pobj contrast,In
R12302 T15958 T15939 punct .,confirmed
R12303 T16071 T16070 prep to,contrast
R12304 T16072 T16073 det the,Th2-differentiating
R12305 T15959 T15976 prep In,failed
R12306 T16073 T16071 pobj Th2-differentiating,to
R12307 T16074 T16073 cc and,Th2-differentiating
R12308 T16075 T16076 amod iTreg-inhibiting,function
R12309 T16076 T16073 conj function,Th2-differentiating
R12310 T15960 T15959 pobj line,In
R12311 T16077 T16076 prep of,function
R12312 T16078 T16077 pobj GATA3,of
R12313 T16079 T16076 prep in,function
R12315 T16080 T16082 amod peripheral,cells
R12316 T16081 T16082 compound T,cells
R12317 T16082 T16079 pobj cells,in
R12318 T16083 T16073 punct ",",Th2-differentiating
R12319 T16084 T16085 amod GATA3,acts
R12320 T16085 T16069 pobj acts,In
R12321 T16086 T16085 prep in,acts
R12322 T16087 T16088 det the,thymus
R12323 T16088 T16086 pobj thymus,in
R12325 T16089 T16085 advmod together,acts
R12326 T16090 T16089 prep with,together
R12328 T16091 T16093 amod other,factors
R12331 T16092 T16093 compound transcription,factors
R12332 T16093 T16090 pobj factors,with
R12333 T16094 T16095 amod such,as
R12335 T16095 T16093 prep as,factors
R12336 T16096 T16097 det the,Repressor
R12338 T16097 T16095 pobj Repressor,as
R12339 T16098 T16097 prep of,Repressor
R12340 T16099 T16098 pobj GATA3,of
R12341 T16100 T16099 punct (,GATA3
R12343 T16101 T16099 appos ROG,GATA3
R12344 T16102 T16099 punct ),GATA3
R12345 T16103 T16097 prep in,Repressor
R12346 T15969 T15970 compound T,cells
R12347 T16104 T16106 det the,process
R12348 T16105 T16106 compound differentiation,process
R12349 T16106 T16103 pobj process,in
R12350 T15970 T15967 pobj cells,in
R12351 T16107 T16106 prep toward,process
R12352 T16108 T16109 compound CD8,cells
R12353 T16109 T16107 pobj cells,toward
R12354 T15971 T15976 punct ",",failed
R12355 T16110 T16112 compound [,]
R12356 T16111 T16112 compound "53,54",]
R12357 T16112 T16097 conj ],Repressor
R12358 T16113 T16112 cc or,]
R12359 T15972 T15976 nsubj cells,failed
R12360 T16114 T16112 conj participates,]
R12361 T16115 T16114 prep in,participates
R12362 T16116 T16119 amod complex,network
R12363 T15973 T15972 prep of,cells
R12364 T16117 T16119 amod transcriptional,network
R12365 T16118 T16119 compound feedback,network
R12366 T15974 T15975 det these,mice
R12367 T16119 T16115 pobj network,in
R12368 T15975 T15973 pobj mice,of
R12369 T16120 T16121 aux to,regulate
R12370 T16121 T16114 advcl regulate,participates
R12371 T16122 T16123 amod sympathoadrenal,differentiation
R12372 T16123 T16121 dobj differentiation,regulate
R12373 T16124 T16126 nmod [,]
R12374 T16125 T16126 nummod 55,]
R12375 T16126 T16123 appos ],differentiation
R12376 T15976 T15976 ROOT failed,failed
R12377 T16127 T16085 punct .,acts
R12378 T16128 T16134 advmod Therefore,appears
R12379 T16129 T16134 punct ",",appears
R12380 T16130 T16131 det the,role
R12381 T15977 T15978 aux to,induce
R12382 T16131 T16134 nsubj role,appears
R12383 T16132 T16131 prep of,role
R12384 T16133 T16132 pobj GATA3,of
R12385 T16134 T16134 ROOT appears,appears
R12386 T16135 T16136 aux to,be
R12387 T15978 T15976 xcomp induce,failed
R12388 T16136 T16134 xcomp be,appears
R12389 T16137 T16138 compound tissue,specific
R12390 T16138 T16136 acomp specific,be
R12391 T15979 T15980 nummod FOXP3,expression
R12392 T16139 T16134 cc and,appears
R12393 T16140 T16143 aux can,generalized
R12394 T15980 T15978 dobj expression,induce
R12395 T16141 T16143 neg not,generalized
R12396 T15981 T15980 prep upon,expression
R12397 T16142 T16143 auxpass be,generalized
R12398 T16143 T16134 conj generalized,appears
R12399 T15982 T15981 pobj exposure,upon
R12400 T16144 T16134 punct .,appears
R12401 T16145 T16146 poss Our,study
R12402 T16146 T16147 nsubj study,demonstrates
R12403 T16189 T16190 nummod 24,]
R12404 T16147 T16147 ROOT demonstrates,demonstrates
R12405 T16148 T16150 mark that,repressed
R12406 T16149 T16150 nsubj GATA3,repressed
R12407 T16150 T16147 ccomp repressed,demonstrates
R12408 T16151 T16152 nummod FOXP3,expression
R12409 T16152 T16150 dobj expression,repressed
R12410 T16153 T16150 advmod directly,repressed
R12411 T16190 T16184 pobj ],as
R12412 T16154 T16150 prep by,repressed
R12413 T16155 T16154 pobj binding,by
R12414 T16156 T16155 prep to,binding
R12415 T16191 T16166 punct .,located
R12416 T16157 T16160 det the,region
R12417 T16158 T16160 nummod FOXP3,region
R12418 T16159 T16160 compound promoter,region
R12419 T16160 T16156 pobj region,to
R12420 T16161 T16147 punct .,demonstrates
R12421 T16162 T16164 det A,GATA-site
R12422 T16163 T16164 amod palindromic,GATA-site
R12423 T16192 T16193 amod Site-specific,mutation
R12424 T16164 T16166 nsubjpass GATA-site,located
R12425 T16165 T16166 auxpass is,located
R12426 T16166 T16166 ROOT located,located
R12427 T16193 T16197 nsubj mutation,increased
R12428 T16167 T16168 nummod 303,bp
R12429 T16168 T16169 compound bp,upstream
R12430 T16169 T16166 advmod upstream,located
R12431 T16170 T16169 prep of,upstream
R12432 T16194 T16193 prep of,mutation
R12433 T16171 T16172 det the,TSS
R12434 T16172 T16170 pobj TSS,of
R12435 T16173 T16166 prep in,located
R12436 T16195 T16196 det this,site
R12437 T16174 T16177 det a,region
R12438 T16175 T16176 advmod highly,conserved
R12439 T16176 T16177 amod conserved,region
R12440 T16196 T16194 pobj site,of
R12441 T16177 T16173 pobj region,in
R12442 T16178 T16177 punct ",",region
R12443 T16179 T16183 dobj which,identified
R12444 T16197 T16197 ROOT increased,increased
R12445 T16180 T16183 nsubj we,identified
R12446 T16181 T16183 aux have,identified
R12447 T16182 T16183 advmod previously,identified
R12449 T16183 T16177 relcl identified,region
R12450 T16184 T16183 prep as,identified
R12451 T16185 T16190 det the,]
R12452 T16186 T16190 nummod FOXP3,]
R12454 T16187 T16188 compound promoter,[
R12455 T16188 T16190 nmod [,]
R12461 T16286 T16278 punct ",",induce
R12463 T16287 T16278 prep by,induce
R12464 T16288 T16289 advmod directly,transactivating
R12465 T16289 T16287 pcomp transactivating,by
R12467 T16290 T16289 dobj promoters,transactivating
R12468 T16291 T16293 nmod [,]
R12469 T16292 T16293 nummod 36,]
R12470 T16293 T16289 dobj ],transactivating
R12471 T16294 T16293 punct ",",]
R12472 T16295 T16289 cc or,transactivating
R12474 T16296 T16278 punct ",",induce
R12475 T16297 T16298 mark as,shown
R12476 T16298 T16278 advcl shown,induce
R12477 T16299 T16298 prep in,shown
R12479 T16300 T16302 det the,study
R12480 T16301 T16302 amod current,study
R12481 T16302 T16299 pobj study,in
R12483 T16303 T16304 punct ",",acts
R12484 T16304 T16304 ROOT acts,acts
R12485 T16305 T16304 prep as,acts
R12487 T16306 T16307 det a,repressor
R12488 T16307 T16305 pobj repressor,as
R12489 T16308 T16307 prep of,repressor
R12491 T16309 T16310 compound gene,expression
R12492 T16310 T16308 pobj expression,of
R12493 T16311 T16312 compound [,"21,57"
R12495 T16312 T16307 appos "21,57",repressor
R12496 T16313 T16314 nummod 59,]
R12497 T16314 T16307 appos ],repressor
R12499 T16315 T16304 punct .,acts
R12500 T16316 T16323 advmod Therefore,required
R12501 T16317 T16323 nsubjpass keeping,required
R12503 T16318 T16319 amod GATA3,expression
R12504 T16319 T16317 dobj expression,keeping
R12505 T16320 T16317 oprd low,keeping
R12507 T16321 T16323 aux might,required
R12508 T16322 T16323 auxpass be,required
R12509 T16323 T16323 ROOT required,required
R12511 T16324 T16325 aux to,induce
R12512 T16325 T16323 xcomp induce,required
R12513 T16326 T16331 amod efficient,generation
R12514 T16327 T16331 nummod FOXP3,generation
R12516 T16328 T16331 nummod +,generation
R12517 T16329 T16331 compound iTreg,generation
R12518 T16330 T16331 compound cell,generation
R12519 T16331 T16325 dobj generation,induce
R12520 T16332 T16323 punct .,required
R12521 T16333 T16335 det The,interactions
R12523 T16334 T16335 amod molecular,interactions
R12524 T16335 T16343 nsubjpass interactions,identified
R12525 T16336 T16335 acl enabling,interactions
R12526 T16337 T16336 dobj GATA3,enabling
R12528 T16338 T16339 aux to,inhibit
R12529 T16339 T16336 xcomp inhibit,enabling
R12530 T16340 T16343 nsubjpass FOXP3,identified
R12532 T16341 T16343 auxpass are,identified
R12533 T16342 T16343 neg not,identified
R12534 T16343 T16343 ROOT identified,identified
R12536 T16344 T16343 advmod yet,identified
R12537 T16345 T16343 punct ",",identified
R12538 T16346 T16343 cc but,identified
R12540 T16347 T16349 det the,site
R12541 T16348 T16349 compound GATA-binding,site
R12542 T16349 T16351 nsubjpass site,located
R12544 T16350 T16351 auxpass is,located
R12545 T16351 T16343 conj located,identified
R12546 T16352 T16351 oprd adjacent,located
R12548 T16353 T16352 prep to,adjacent
R12549 T16354 T16353 amod positive,to
R12551 T16355 T16351 punct ",",located
R12553 T16356 T16351 advcl inducing,located
R12554 T16357 T16356 dobj sites,inducing
R12555 T16358 T16357 punct ",",sites
R12557 T16359 T16357 acl composed,sites
R12558 T16360 T16359 prep of,composed
R12560 T16361 T16362 amod AP-1-NFATc2,sites
R12561 T16362 T16360 pobj sites,of
R12562 T16363 T16365 nmod [,]
R12564 T16364 T16365 nummod 24,]
R12565 T16365 T16370 nsubj ],compete
R12566 T16366 T16365 punct ",",]
R12568 T16367 T16365 cc and,]
R12569 T16368 T16365 conj GATA3,]
R12570 T16369 T16370 aux may,compete
R12571 T16370 T16343 conj compete,identified
R12572 T16371 T16370 prep with,compete
R12573 T16372 T16373 det the,binding
R12574 T16373 T16371 pobj binding,with
R12576 T16374 T16373 prep of,binding
R12577 T16375 T16377 compound AP-1,NFAT
R12578 T16376 T16377 compound /,NFAT
R12579 T16377 T16374 pobj NFAT,of
R12580 T16232 T16229 pobj cells,in
R12581 T16378 T16373 prep to,binding
R12582 T16379 T16380 det the,promoter
R12583 T16380 T16378 pobj promoter,to
R12584 T16233 T16232 punct ",",cells
R12585 T16381 T16380 punct (,promoter
R12586 T16382 T16383 amod unpublished,observations
R12587 T16234 T16237 nsubj which,express
R12588 T16235 T16237 aux do,express
R12589 T16236 T16237 neg not,express
R12590 T16383 T16380 appos observations,promoter
R12591 T16237 T16232 relcl express,cells
R12592 T16384 T16380 punct ),promoter
R12593 T16385 T16370 punct .,compete
R12594 T16386 T16390 prep In,demonstrated
R12595 T16238 T16237 dobj GATA3,express
R12596 T16387 T16386 pobj summary,In
R12597 T16388 T16390 punct ",",demonstrated
R12598 T16239 T16197 punct .,increased
R12599 T16389 T16390 nsubj we,demonstrated
R12600 T16390 T16390 ROOT demonstrated,demonstrated
R12601 T16391 T16395 mark that,regulated
R12602 T16240 T16243 det This,element
R12603 T16392 T16395 nsubjpass FOXP3,regulated
R12604 T16393 T16395 auxpass is,regulated
R12605 T16394 T16395 advmod negatively,regulated
R12606 T16241 T16243 amod palindromic,element
R12607 T16395 T16390 ccomp regulated,demonstrated
R12608 T16396 T16395 agent by,regulated
R12609 T16397 T16396 pobj cytokines,by
R12611 T16398 T16399 amod such,as
R12612 T16399 T16397 prep as,cytokines
R12613 T16400 T16399 pobj IL-4,as
R12615 T16401 T16390 punct .,demonstrated
R12616 T16402 T16403 nummod GATA3,acts
R12617 T16403 T16403 ROOT acts,acts
R12618 T16404 T16403 prep as,acts
R12620 T16405 T16406 det an,inhibitor
R12622 T16406 T16404 pobj inhibitor,as
R12623 T16407 T16406 prep of,inhibitor
R12625 T16408 T16409 nummod FOXP3,expression
R12626 T16409 T16407 pobj expression,of
R12627 T16410 T16406 prep in,inhibitor
R12629 T16411 T16414 amod early,differentiation
R12630 T16412 T16414 compound T,differentiation
R12631 T16413 T16414 compound cell,differentiation
R12632 T16414 T16410 pobj differentiation,in
R12634 T16415 T16406 punct ",",inhibitor
R12635 T16416 T16418 advmod as,as
R12637 T16417 T16418 advmod well,as
R12638 T16418 T16404 cc as,as
R12639 T16419 T16404 prep in,as
R12640 T16420 T16422 amod differentiated,cells
R12642 T16421 T16422 amod Th2,cells
R12643 T16422 T16419 pobj cells,in
R12644 T16423 T16403 prep by,acts
R12646 T16424 T16425 advmod directly,binding
R12647 T16425 T16403 advcl binding,acts
R12648 T16426 T16425 cc and,binding
R12650 T16427 T16425 conj repressing,binding
R12651 T16428 T16430 det the,promoter
R12652 T16429 T16430 nummod FOXP3,promoter
R12653 T16430 T16427 dobj promoter,repressing
R12655 T16431 T16403 punct .,acts
R12656 T16432 T16434 nsubj We,describe
R12657 T16433 T16434 advmod therefore,describe
R12660 T16434 T16434 ROOT describe,describe
R12661 T16435 T16437 det a,mechanism
R12662 T16436 T16437 amod new,mechanism
R12664 T16437 T16434 dobj mechanism,describe
R12665 T16438 T16437 prep of,mechanism
R12666 T16439 T16441 advmod how,avoids
R12668 T16440 T16441 nsubj Il-4,avoids
R12669 T16441 T16438 pcomp avoids,of
R12670 T16442 T16443 compound tolerance,induction
R12671 T16443 T16441 dobj induction,avoids
R12672 T16444 T16434 prep by,describe
R12673 T16445 T16444 pcomp repressing,by
R12675 T16446 T16447 nummod FOXP3,expression
R12676 T16447 T16445 dobj expression,repressing
R12677 T16448 T16434 punct .,describe
R12678 T16449 T16450 det These,findings
R12680 T16450 T16452 nsubj findings,give
R12681 T16451 T16452 aux will,give
R12683 T16452 T16452 ROOT give,give
R12684 T16453 T16454 amod new,perspectives
R12685 T16454 T16452 dobj perspectives,give
R12686 T16455 T16454 prep toward,perspectives
R12688 T16456 T16455 pcomp understanding,toward
R12689 T16457 T16458 amod molecular,mechanisms
R12690 T16458 T16456 dobj mechanisms,understanding
R12692 T16459 T16458 prep of,mechanisms
R12693 T16460 T16461 compound iTreg,induction
R12695 T16461 T16459 pobj induction,of
R12696 T16462 T16455 cc and,toward
R12697 T16463 T16464 amod thus,pathways
R12699 T16464 T16455 pobj pathways,toward
R12700 T16465 T16464 prep of,pathways
R12701 T16466 T16468 amod peripheral,induction
R12703 T16467 T16468 compound tolerance,induction
R12704 T16468 T16465 pobj induction,of
R12705 T16469 T16464 punct ",",pathways
R12707 T16470 T16471 advmod particularly,in
R12708 T16471 T16452 prep in,give
R12709 T16472 T16471 pobj allergy,in
R12711 T16473 T16472 cc and,allergy
R12712 T16474 T16472 conj asthma,allergy
R12713 T16475 T16452 punct .,give
R12726 T16277 T16278 aux can,induce
R12728 T16278 T16274 ccomp induce,known
R12730 T16279 T16278 dobj transcription,induce
R12733 T16280 T16278 prep by,induce
R12740 T16281 T16280 pobj chromatin,by
R12741 T16282 T16285 nmod remodeling,]
R12742 T16283 T16282 dobj [,remodeling
R12746 T16284 T16285 nummod 56,]
R12750 T16285 T16278 npadvmod ],induce
R11508 T15252 T15255 nsubj cells,up-regulate
R11509 T15253 T15255 aux could,up-regulate
R11510 T15254 T15255 advmod efficiently,up-regulate
R11511 T15255 T15255 ROOT up-regulate,up-regulate
R11512 T15256 T15255 dobj FOXP3,up-regulate
R11513 T15257 T15258 advmod when,treated
R11514 T15258 T15255 advcl treated,up-regulate
R11515 T15259 T15258 prep with,treated
R11516 T15260 T15259 pobj TGF-β,with
R11517 T15261 T15262 aux to,induce
R11518 T15262 T15258 advcl induce,treated
R11519 T15263 T15264 amod iTreg,cells
R11520 T15264 T15262 dobj cells,induce
R11521 T15265 T15266 compound [,"10,28"
R11522 T15266 T15255 dep "10,28",up-regulate
R11523 T15267 T15268 nummod 34,]
R11524 T15268 T15266 appos ],"10,28"
R11525 T15269 T15255 punct ",",up-regulate
R11526 T15270 T15255 advcl suggesting,up-regulate
R11527 T15271 T15273 mark that,plays
R11528 T15272 T15273 nsubj FOXP3,plays
R11529 T15273 T15270 ccomp plays,suggesting
R11530 T15274 T15276 det an,role
R11531 T15275 T15276 amod important,role
R11532 T15276 T15273 dobj role,plays
R11533 T15277 T15276 prep in,role
R11534 T15278 T15281 det the,process
R11535 T15279 T15281 amod early,process
R11536 T15280 T15281 compound differentiation,process
R11537 T15281 T15277 pobj process,in
R11557 T15301 T15302 det This,commitment
R11558 T15302 T15304 nsubjpass commitment,characterized
R11559 T15303 T15304 auxpass is,characterized
R11560 T15304 T15304 ROOT characterized,characterized
R11561 T15305 T15304 agent by,characterized
R11562 T15306 T15307 amod competitive,expression
R11563 T15307 T15305 pobj expression,by
R11564 T15308 T15307 prep of,expression
R11565 T15309 T15310 det these,factors
R11566 T15310 T15308 pobj factors,of
R11567 T15311 T15313 compound [,]
R11568 T15312 T15313 compound "35,36",]
R11569 T15313 T15307 appos ],expression
R11570 T15314 T15307 punct ",",expression
R11571 T15315 T15318 dobj which,observed
R11572 T15316 T15318 nsubj we,observed
R11573 T15317 T15318 advmod also,observed
R11574 T15318 T15307 relcl observed,expression
R11575 T15319 T15318 prep in,observed
R11576 T15320 T15319 pcomp differentiating,in
R11577 T15321 T15324 nummod FOXP3,cells
R11578 T15322 T15324 nummod +,cells
R11579 T15323 T15324 compound iTreg,cells
R11580 T15324 T15320 dobj cells,differentiating
R11581 T15325 T15324 prep including,cells
R11582 T15326 T15327 det a,phase
R11583 T15327 T15325 pobj phase,including
R11584 T15328 T15327 prep of,phase
R11585 T15329 T15328 pobj co-expression,of
R11586 T15330 T15329 punct ",",co-expression
R11587 T15331 T15332 nsubj which,turns
R11588 T15332 T15327 relcl turns,phase
R11589 T15333 T15332 prep into,turns
R11590 T15334 T15335 amod nonoverlapping,expression
R11591 T15335 T15333 pobj expression,into
R11592 T15336 T15335 prep upon,expression
R11593 T15337 T15338 amod completed,differentiation
R11594 T15338 T15336 pobj differentiation,upon
R11595 T15339 T15304 punct .,characterized
R11596 T15340 T15345 prep In,appeared
R11597 T15341 T15343 det this,process
R11598 T15342 T15343 amod competitive,process
R11599 T15343 T15340 pobj process,In
R11600 T15344 T15345 nsubj TGF-β,appeared
R11601 T15345 T15345 ROOT appeared,appeared
R11602 T15346 T15347 aux to,be
R11603 T15347 T15345 xcomp be,appeared
R11604 T15348 T15347 acomp mandatory,be
R11605 T15349 T15347 prep for,be
R11606 T15350 T15351 det the,induction
R11607 T15351 T15349 pobj induction,for
R11608 T15352 T15351 prep of,induction
R11609 T15353 T15352 pobj FOXP3,of
R11610 T15354 T15347 punct ",",be
R11611 T15355 T15356 advmod possibly,by
R11612 T15356 T15347 prep by,be
R11613 T15357 T15356 pcomp keeping,by
R11614 T15358 T15359 det the,expression
R11615 T15359 T15357 dobj expression,keeping
R11616 T15360 T15359 prep of,expression
R11617 T15361 T15360 pobj GATA3,of
R11635 T15379 T15378 prep of,absence
R11636 T15380 T15381 compound polarization,factors
R11637 T15381 T15379 pobj factors,of
R11638 T15382 T15378 punct (,absence
R11639 T15383 T15378 appos Th0,absence
R11640 T15384 T15378 punct ),absence
R11641 T15385 T15386 amod such,as
R11642 T15386 T15372 prep as,differentiating
R11643 T15387 T15386 pobj IL-4,as
R11644 T15388 T15387 punct ",",IL-4
R11645 T15389 T15387 conj IL-12,IL-4
R11646 T15390 T15389 punct ",",IL-12
R11647 T15391 T15389 cc or,IL-12
R11648 T15392 T15393 nsubj TGF-β,showed
R11649 T15393 T15393 ROOT showed,showed
R11650 T15394 T15398 advmod only,expression
R11651 T15395 T15398 det a,expression
R11652 T15396 T15398 amod transient,expression
R11653 T15397 T15398 nummod FOXP3,expression
R11654 T15398 T15393 dobj expression,showed
R11655 T15399 T15393 cc and,showed
R11656 T15400 T15393 conj failed,showed
R11657 T15401 T15402 aux to,generate
R11658 T15402 T15400 xcomp generate,failed
R11659 T15403 T15404 det a,population
R11660 T15404 T15402 dobj population,generate
R11661 T15405 T15404 prep of,population
R11662 T15406 T15407 amod FOXP3-expressing,cells
R11663 T15407 T15405 pobj cells,of
R11664 T15408 T15400 punct ",",failed
R11665 T15409 T15393 cc but,showed
R11666 T15410 T15413 nsubj GATA3,were
R11667 T15411 T15410 cc and,GATA3
R11668 T15412 T15410 conj T-bet,GATA3
R11669 T15413 T15393 conj were,showed
R11670 T15414 T15413 acomp up-regulated,were
R11671 T15415 T15414 punct (,up-regulated
R11672 T15416 T15417 amod unpublished,data
R11673 T15417 T15414 appos data,up-regulated
R11674 T15418 T15414 punct ),up-regulated
R11675 T15419 T15413 punct .,were
R11676 T15420 T15452 advmod Interestingly,known
R11677 T15421 T15452 punct ",",known
R11678 T15422 T15427 mark as,described
R11679 T15423 T15427 nsubj we,described
R11680 T15424 T15423 cc and,we
R11681 T15425 T15423 conj others,we
R11682 T15426 T15427 advmod previously,described
R11683 T15427 T15452 advcl described,known
R11684 T15428 T15430 punct ",",factors
R11685 T15429 T15430 amod FOXP3-promoting,factors
R11686 T15430 T15427 dobj factors,described
R11687 T15431 T15430 punct ",",factors
R11688 T15432 T15433 amod such,as
R11689 T15433 T15430 prep as,factors
R11690 T15434 T15435 compound dexamethasone,[
R11691 T15435 T15437 nmod [,]
R11692 T15436 T15437 nummod 39,]
R11693 T15437 T15433 pobj ],as
R11694 T15438 T15437 punct ",",]
R11695 T15439 T15440 compound CTLA-4,[
R11696 T15440 T15452 nsubjpass [,known
R11713 T15457 T15455 pobj expression,of
R11714 T15458 T15454 conj [,inhibitors
R11715 T15459 T15458 nummod 42,[
R11716 T15460 T15461 nummod 45,]
R11717 T15461 T15458 appos ],[
R11718 T15462 T15452 punct .,known
R11719 T15463 T15467 advmod Therefore,induces
R11720 T15464 T15467 nsubj GATA3,induces
R11721 T15465 T15467 preconj not,induces
R11722 T15466 T15465 advmod only,not
R11723 T15467 T15467 ROOT induces,induces
R11724 T15468 T15467 dobj differentiation,induces
R11725 T15469 T15467 prep into,induces
R11726 T15470 T15471 amod Th2,cells
R11727 T15471 T15469 pobj cells,into
R11728 T15472 T15467 cc but,induces
R11729 T15473 T15474 advmod also,inhibits
R11730 T15474 T15467 conj inhibits,induces
R11731 T15475 T15476 nummod FOXP3,expression
R11732 T15476 T15474 dobj expression,inhibits
R11733 T15477 T15476 cc and,expression
R11734 T15478 T15476 conj commitment,expression
R11735 T15479 T15476 prep into,expression
R11736 T15480 T15481 compound iTreg,cells
R11737 T15481 T15479 pobj cells,into
R11738 T15482 T15467 punct .,induces
R11739 T15483 T15486 det The,IL-4
R11740 T15484 T15486 amod Th2,IL-4
R11741 T15485 T15486 compound cytokine,IL-4
R11742 T15486 T15494 nsubj IL-4,was
R11791 T15605 T15606 det a,distinction
R11793 T15606 T15604 pobj distinction,since
R11795 T15607 T15606 prep of,distinction
R11796 T15608 T15611 nmod nTreg,cells
R11797 T15609 T15608 cc and,nTreg
R11799 T15610 T15608 conj iTreg,nTreg
R11800 T15611 T15607 pobj cells,of
R11801 T15612 T15630 advcl is,exclude
R11802 T15613 T15612 advmod currently,is
R11804 T15614 T15612 neg not,is
R11920 T15567 T15570 amod natural,Treg
R11921 T15568 T15567 cc or,natural
R11922 T15569 T15567 conj inducible,natural
R11924 T15570 T15566 pobj Treg,of
R11928 T15571 T15573 punct (,+
R11931 T15572 T15573 compound CD25,+
R11935 T15573 T15562 appos +,decrease
R11939 T15574 T15573 cc and,+
R11943 T15575 T15576 compound Foxp3,+
R11948 T15576 T15573 conj +,+
R11951 T15577 T15573 punct ),+
R11954 T15578 T15559 dobj cells,resulted
R11956 T15579 T15580 nummod 7,d
R11959 T15580 T15578 prep d,cells
R11963 T15581 T15580 prep after,d
R11970 T15582 T15581 pobj treatment,after
R11974 T15583 T15580 punct .,d
R11978 T15584 T15585 poss Our,results
R11982 T15585 T15586 nsubj results,suggest
R11986 T15586 T15586 ROOT suggest,suggest
R11990 T15587 T15591 mark that,interfering
R11806 T15615 T15612 acomp possible,is
R11807 T15616 T15612 punct ",",is
R11809 T15617 T15622 mark because,express
R11810 T15618 T15619 compound iTreg,cells
R11811 T15619 T15622 nsubj cells,express
R11813 T15620 T15621 advmod also,transiently
R11814 T15621 T15622 advmod transiently,express
R11815 T15622 T15630 advcl express,exclude
R11816 T15623 T15622 dobj CD25,express
R11817 T15624 T15622 prep after,express
R11818 T15625 T15624 pobj activation,after
R11820 T15626 T15630 punct ",",exclude
R11821 T15627 T15630 nsubj we,exclude
R11822 T15628 T15630 aux can,exclude
R11824 T15629 T15630 neg not,exclude
R11825 T15630 T15630 ROOT exclude,exclude
R11826 T15631 T15635 mark that,inhibit
R11828 T15632 T15635 nsubj IL-4,inhibit
R11829 T15633 T15635 aux may,inhibit
R11831 T15634 T15635 advmod also,inhibit
R11832 T15635 T15630 ccomp inhibit,exclude
R11833 T15636 T15637 amod Foxp3,expression
R11834 T15637 T15635 dobj expression,inhibit
R11835 T15638 T15635 prep in,inhibit
R11837 T15639 T15640 compound nTreg,cells
R11838 T15640 T15638 pobj cells,in
R11839 T15641 T15640 prep in,cells
R11841 T15642 T15641 pobj vivo,in
R11842 T15643 T15635 cc or,inhibit
R11843 T15644 T15648 mark that,contribute
R11844 T15645 T15646 amod additional,effects
R11847 T15646 T15648 nsubj effects,contribute
R11848 T15647 T15648 aux may,contribute
R11850 T15648 T15635 conj contribute,inhibit
R11851 T15649 T15648 prep to,contribute
R11852 T15650 T15652 det the,drop
R11853 T15651 T15652 amod observed,drop
R11855 T15652 T15649 pobj drop,to
R11858 T15653 T15652 prep in,drop
R11859 T15654 T15655 amod Foxp3,expression
R11861 T15655 T15653 pobj expression,in
R11862 T15656 T15630 punct .,exclude
R11864 T15657 T15661 nsubjpass IL-4,shown
R11865 T15658 T15661 aux has,shown
R11866 T15659 T15661 advmod already,shown
R11867 T15660 T15661 auxpass been,shown
R11868 T15661 T15661 ROOT shown,shown
R11869 T15662 T15664 aux to,regulate
R11870 T15663 T15664 advmod negatively,regulate
R11871 T15664 T15661 xcomp regulate,shown
R11873 T15665 T15666 det the,development
R11874 T15666 T15664 dobj development,regulate
R11875 T15667 T15666 prep of,development
R11876 T15668 T15670 amod naive,cells
R11878 T15669 T15670 compound T,cells
R11879 T15670 T15667 pobj cells,of
R11880 T15671 T15664 prep into,regulate
R11881 T15672 T15671 pobj Th1,into
R11883 T15673 T15672 cc or,Th1
R11884 T15674 T15675 det the,IL-17
R11885 T15675 T15672 conj IL-17,Th1
R11911 T15694 T15693 punct ",",IL-6
R11912 T15695 T15701 nsubj which,inhibits
R11914 T15696 T15701 punct ",",inhibits
R11915 T15697 T15701 advcl combined,inhibits
R11916 T15698 T15697 prep with,combined
R11917 T15699 T15698 pobj TGF-β,with
R11918 T15700 T15701 punct ",",inhibits
R11919 T15701 T15693 relcl inhibits,IL-6
R11923 T15702 T15703 det the,generation
R11925 T15703 T15701 dobj generation,inhibits
R11926 T15704 T15703 prep of,generation
R11927 T15705 T15706 compound iTreg,cells
R11929 T15706 T15704 pobj cells,of
R11930 T15707 T15701 cc and,inhibits
R11932 T15708 T15701 conj induces,inhibits
R11933 T15709 T15708 dobj differentiation,induces
R11934 T15710 T15708 prep into,induces
R11936 T15711 T15713 det the,cells
R11937 T15712 T15713 compound Th17,cells
R11938 T15713 T15710 pobj cells,into
R11940 T15714 T15708 prep by,induces
R11941 T15715 T15717 det an,mechanism
R11942 T15716 T15717 amod unknown,mechanism
R11944 T15717 T15714 pobj mechanism,by
R11945 T15718 T15720 compound [,]
R11946 T15719 T15720 compound "48,49",]
R11947 T15720 T15717 appos ],mechanism
R11949 T15721 T15691 punct .,described
R11950 T15722 T15730 advmod Thus,regulated
R11952 T15723 T15724 det the,polarization
R11953 T15724 T15730 nsubjpass polarization,regulated
R12124 T15850 T15849 pobj GATA3,by
R12125 T15851 T15838 punct .,hypothesized
R12127 T15852 T15858 prep In,repressed
R12128 T15853 T15852 pobj fact,In
R12129 T15854 T15858 punct ",",repressed
R12131 T15855 T15857 amod GATA3-inducing,concentrations
R12132 T15856 T15857 compound IL-4,concentrations
R12133 T15857 T15858 nsubj concentrations,repressed
R12135 T15858 T15858 ROOT repressed,repressed
R12136 T15859 T15858 dobj TGF-β,repressed
R12138 T15860 T15858 conj mediated,repressed
R12139 T15861 T15862 nummod FOXP3,expression
R12140 T15862 T15860 dobj expression,mediated
R12142 T15863 T15860 punct ",",mediated
R12143 T15864 T15871 mark whereas,were
R12144 T15865 T15871 nsubj IL-4,were
R12146 T15866 T15868 advmod as,as
R12147 T15867 T15868 advmod well,as
R12150 T15868 T15865 cc as,IL-4
R12151 T15869 T15865 conj TGF-β,IL-4
R12153 T15870 T15865 conj signaling,IL-4
R12154 T15871 T15860 advcl were,mediated
R12155 T15872 T15871 acomp intact,were
R12156 T15873 T15858 punct .,repressed
R12158 T15874 T15875 det This,result
R12159 T15875 T15876 nsubj result,suggested
R12160 T15876 T15876 ROOT suggested,suggested
R12162 T15877 T15879 det a,mechanism
R12163 T15878 T15879 amod competitive,mechanism
R12165 T15879 T15876 dobj mechanism,suggested
R12166 T15880 T15879 prep between,mechanism
R12055 T15887 T15886 pcomp determining,in
R12060 T15888 T15889 compound lineage,commitment
R12062 T15889 T15887 dobj commitment,determining
R12065 T15890 T15887 prep during,determining
R12072 T15891 T15893 det the,phase
R12076 T15892 T15893 amod early,phase
R12080 T15893 T15890 pobj phase,during
R12084 T15894 T15893 prep of,phase
R12088 T15895 T15894 pobj differentiation,of
R12092 T15896 T15876 punct .,suggested
R12096 T15897 T15900 advmod Accordingly,investigated
R12100 T15898 T15900 punct ",",investigated
R12105 T15899 T15900 nsubj we,investigated
R12109 T15900 T15900 ROOT investigated,investigated
R12113 T15901 T15902 advmod naturally,high
R12120 T15902 T15904 amod high,cells
R12122 T15903 T15904 amod GATA3-expressing,cells
R12123 T15904 T15900 dobj cells,investigated
R12126 T15905 T15900 cc and,investigated
R12130 T15906 T15900 conj confirmed,investigated
R12134 T15907 T15908 det the,absence
R12137 T15908 T15906 dobj absence,confirmed
R12141 T15909 T15908 prep of,absence
R12145 T15910 T15909 pobj FOXP3,of
R12148 T15911 T15900 punct .,investigated
R12149 T15912 T15913 compound Protein,transduction
R12152 T15913 T15920 nsubj transduction,inhibited
R12157 T15914 T15913 prep of,transduction
R12161 T15915 T15914 pobj GATA3,of
R12164 T15916 T15913 prep into,transduction
R12167 T15881 T15880 pobj GATA3,between
R12180 T15983 T15982 prep with,exposure
R12181 T15984 T15983 pobj antigen,with
R12182 T15985 T15978 prep in,induce
R12184 T15986 T15987 det the,presence
R12185 T15987 T15985 pobj presence,in
R12186 T15988 T15987 prep of,presence
R12188 T15989 T15988 pobj TGF-β,of
R12189 T15990 T15976 punct .,failed
R12190 T15991 T16000 advmod Strikingly,have
R12192 T15992 T16000 punct ",",have
R12193 T15993 T16000 dep the,have
R12194 T15994 T16000 dep DO11,have
R12198 T15995 T15994 nummod .10,DO11
R12199 T15996 T16000 punct :,have
R12201 T15997 T15998 amod CD2-GATA3,mice
R12202 T15998 T16000 nsubj mice,have
R12204 T15999 T16000 aux do,have
R12205 T16000 T16000 ROOT have,have
R12206 T16001 T16004 amod peripheral,cells
R12208 T16002 T16004 nummod FOXP3,cells
R12209 T16003 T16004 compound +,cells
R12210 T16004 T16000 dobj cells,have
R12212 T16005 T16004 punct ",",cells
R12213 T16006 T16008 nsubj which,displayed
R12314 T15961 T15960 prep with,line
R12324 T15962 T15964 det the,overexpression
R12327 T15963 T15964 amod transient,overexpression
R12329 T15964 T15961 pobj overexpression,with
R12330 T15965 T15964 prep of,overexpression
R12334 T15966 T15965 pobj GATA3,of
R12337 T15967 T15964 prep in,overexpression
R12342 T15968 T15970 amod human,cells
R12448 T16198 T16199 det the,activity
R12453 T16199 T16197 dobj activity,increased
R12456 T16200 T16199 prep of,activity
R12457 T16201 T16203 det the,constructs
R12458 T16202 T16203 compound promoter,constructs
R12459 T16203 T16200 pobj constructs,of
R12460 T16204 T16197 punct ",",increased
R12462 T16205 T16206 advmod thus,revealing
R12466 T16206 T16197 advcl revealing,increased
R12473 T16207 T16209 det the,nature
R12478 T16208 T16209 amod repressive,nature
R12482 T16209 T16206 dobj nature,revealing
R12486 T16210 T16209 prep of,nature
R12490 T16211 T16213 det this,element
R12494 T16212 T16213 compound GATA,element
R12498 T16213 T16210 pobj element,of
R12502 T16214 T16213 prep in,element
R12506 T16215 T16217 compound memory,cells
R12510 T16216 T16217 compound T,cells
R12515 T16217 T16214 pobj cells,in
R12522 T16218 T16213 punct ",",element
R12527 T16219 T16221 nsubj which,express
R12531 T16220 T16221 advmod naturally,express
R12535 T16221 T16209 relcl express,nature
R12539 T16222 T16221 dobj GATA3,express
R12543 T16223 T16206 punct ",",revealing
R12547 T16224 T16228 mark whereas,seen
R12550 T16225 T16226 det no,difference
R12552 T16226 T16228 nsubjpass difference,seen
R12556 T16227 T16228 auxpass was,seen
R12559 T16228 T16206 advcl seen,revealing
R12563 T16229 T16228 prep in,seen
R12567 T16230 T16232 amod naive,cells
R12575 T16231 T16232 compound T,cells
R12610 T16242 T16243 compound GATA,element
R12614 T16243 T16245 nsubjpass element,bound
R12619 T16244 T16245 auxpass is,bound
R12621 T16245 T16245 ROOT bound,bound
R12624 T16246 T16245 agent by,bound
R12628 T16247 T16248 compound GATA3,protein
R12633 T16248 T16246 pobj protein,by
R12636 T16249 T16250 mark as,proven
R12641 T16250 T16245 advcl proven,bound
R12645 T16251 T16250 prep with,proven
R12649 T16252 T16253 amod pull-down,experiments
R12654 T16253 T16251 pobj experiments,with
R12658 T16254 T16245 punct .,bound
R12659 T16255 T16259 advmod Furthermore,shown
R12663 T16256 T16259 punct ",",shown
R12667 T16257 T16259 nsubjpass it,shown
R12674 T16258 T16259 auxpass is,shown
R12679 T16259 T16259 ROOT shown,shown
R12682 T16260 T16259 agent by,shown
R12687 T16261 T16260 pobj ChIP,by
R12691 T16262 T16264 nsubj that,binds
R12694 T16263 T16264 nsubj GATA3,binds
R12698 T16264 T16259 ccomp binds,shown
R12702 T16265 T16266 det this,element
R12706 T16266 T16264 dobj element,binds
R12710 T16267 T16264 advmod also,binds
R12714 T16268 T16264 prep in,binds
R12715 T16269 T16270 amod intact,cells
R12716 T16270 T16268 pobj cells,in
R12717 T16271 T16259 punct .,shown
R12718 T16272 T16274 nsubjpass It,known
R12719 T16273 T16274 auxpass is,known
R12720 T16274 T16304 ccomp known,acts
R12722 T16275 T16278 mark that,induce
R12724 T16276 T16278 nsubj GATA3,induce

UBERON-AE

Id Subject Object Predicate Lexical cue
T13431 5307-5313 http://purl.obolibrary.org/obo/UBERON_0002370 denotes thymus
T13432 5602-5608 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

GO-BP

Id Subject Object Predicate Lexical cue
T13480 422-428 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T13481 6060-6066 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T13482 2900-2911 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T13483 4941-4952 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T13484 4024-4033 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T13485 4117-4130 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13486 5334-5347 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13487 6397-6410 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13488 4327-4339 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T13489 6414-6434 http://purl.obolibrary.org/obo/GO_0006338 denotes chromatin remodeling
T13490 6543-6558 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T13491 7116-7136 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T13492 7289-7308 http://purl.obolibrary.org/obo/GO_0002507 denotes tolerance induction
T13493 7476-7495 http://purl.obolibrary.org/obo/GO_0002507 denotes tolerance induction
T13494 7465-7495 http://purl.obolibrary.org/obo/GO_0002660 denotes peripheral tolerance induction
T13495 7465-7495 http://purl.obolibrary.org/obo/GO_0002659 denotes peripheral tolerance induction
T13496 7465-7495 http://purl.obolibrary.org/obo/GO_0002465 denotes peripheral tolerance induction
T13497 7465-7495 http://purl.obolibrary.org/obo/GO_0002658 denotes peripheral tolerance induction

GO-MF

Id Subject Object Predicate Lexical cue
T16685 1391-1395 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16686 1922-1926 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16687 2111-2115 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16688 2186-2190 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16689 2200-2204 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16690 2288-2292 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16691 2293-2297 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16692 2447-2451 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16693 2699-2703 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16694 2845-2849 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16695 3277-3281 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16696 3292-3296 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16697 3436-3440 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16698 3481-3485 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16699 3625-3629 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16700 3844-3848 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16701 3931-3935 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16702 4002-4006 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16703 7052-7056 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16704 1397-1402 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T16705 1935-1940 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T16706 3752-3757 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T16707 2945-2950 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T16708 3034-3038 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T16709 3286-3290 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T16710 5718-5725 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16711 6774-6781 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16712 6903-6910 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16713 7189-7196 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T16714 176-181 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16715 223-228 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16716 344-349 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16717 408-413 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16718 431-436 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16719 445-450 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16720 608-613 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16721 690-695 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16722 1024-1029 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16723 1332-1337 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16724 1510-1515 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16725 1831-1836 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16726 1898-1903 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16727 2395-2400 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16728 2508-2513 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16729 2525-2530 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16730 2575-2580 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16731 2622-2627 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16732 2747-2752 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16733 2923-2928 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16734 2963-2968 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16735 3101-3106 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16736 3149-3154 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16737 3221-3226 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16738 3363-3368 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16739 3663-3668 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16740 4277-4282 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16741 4362-4367 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16742 4429-4434 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16743 4539-4544 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16745 4651-4656 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16746 4823-4828 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16747 5067-5072 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16748 5282-5287 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16749 5435-5440 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16750 6069-6074 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16751 6149-6154 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16752 6356-6361 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16753 7171-7176 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16754 6414-6423 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T16744 4644-4649 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T13433 11-182 Sentence denotes The current study reveals that FOXP3 induction, an important step in iTreg commitment, is inhibited by GATA3, which is the key regulator for polarization toward Th2 cells.
T13434 183-285 Sentence denotes After differentiation, the effector Th2 cells become refractory to conversion into a FOXP3+ phenotype.
T13435 286-389 Sentence denotes In accordance with other studies, we found that CD4+CD25– cells were able to up-regulate FOXP3 [12,27].
T13436 390-586 Sentence denotes Already-committed cells such as memory T cells and Th1 cells showed only moderate and transient FOXP3 induction, which is not sufficient to change the phenotype toward a regulatory T cell profile.
T13437 587-883 Sentence denotes In contrast, naive T cells could efficiently up-regulate FOXP3 when treated with TGF-β to induce iTreg cells [10,28–34], suggesting that FOXP3 plays an important role in the early differentiation process and may act in a way similar to that known for the Th1/Th2 decision factors T-bet and GATA3.
T13438 884-1140 Sentence denotes This commitment is characterized by competitive expression of these factors [35,36], which we also observed in differentiating FOXP3+ iTreg cells including a phase of co-expression, which turns into nonoverlapping expression upon completed differentiation.
T13439 1141-1294 Sentence denotes In this competitive process TGF-β appeared to be mandatory for the induction of FOXP3, possibly by keeping the expression of GATA3 and T-bet low [37,38].
T13440 1295-1574 Sentence denotes In contrast, differentiating naive T cells in the absence of polarization factors (Th0) such as IL-4, IL-12, or TGF-β showed only a transient FOXP3 expression and failed to generate a population of FOXP3-expressing cells, but GATA3 and T-bet were up-regulated (unpublished data).
T13441 1575-1772 Sentence denotes Interestingly, as we and others previously described, FOXP3-promoting factors, such as dexamethasone [39], CTLA-4 [40], and estrogens [41], are also known as inhibitors of GATA3 expression [42–45].
T13442 1773-1904 Sentence denotes Therefore GATA3 not only induces differentiation into Th2 cells but also inhibits FOXP3 expression and commitment into iTreg cells.
T13443 1905-2076 Sentence denotes The Th2 cytokine IL-4 but not IL-13 (unpublished data) was able to inhibit TGF-β–mediated FOXP3 induction and therefore prevented conversion into the regulatory phenotype.
T13444 2077-2205 Sentence denotes To prove the inhibitory effect of IL-4 on inducible or natural Treg commitment in vivo, we treated mice with IL-4 and anti-IL-4.
T13445 2206-2278 Sentence denotes This has been shown to increase the effect of the cytokine in vivo [19].
T13446 2279-2421 Sentence denotes Only the IL-4/IL-4 mAb complex resulted in a decrease of the amount of natural or inducible Treg (CD25+ and Foxp3+) cells 7 d after treatment.
T13447 2422-2531 Sentence denotes Our results suggest that IL-4 is only interfering with the differentiation of naive T cells into iTreg cells.
T13448 2532-2844 Sentence denotes But since a distinction of nTreg and iTreg cells is currently not possible, because iTreg cells also transiently express CD25 after activation, we cannot exclude that IL-4 may also inhibit Foxp3 expression in nTreg cells in vivo or that additional effects may contribute to the observed drop in Foxp3 expression.
T13449 2845-2984 Sentence denotes IL-4 has already been shown to negatively regulate the development of naive T cells into Th1 or the IL-17–producing T cells (Th17) [46,47].
T13450 2985-3187 Sentence denotes Similar effects have been recently described for IL-6, which, combined with TGF-β, inhibits the generation of iTreg cells and induces differentiation into the Th17 cells by an unknown mechanism [48,49].
T13451 3188-3291 Sentence denotes Thus the polarization into iTreg cells is negatively regulated by the effector cytokines IL-4 and IL-6.
T13452 3292-3391 Sentence denotes IL-4 has been previously shown to induce the generation of FOXP3+ Treg cells out of CD4+CD25– [50].
T13453 3392-3542 Sentence denotes In those experiments, the concentrations of IL-4 used were low, and as we also observed, IL-4 at low concentration slightly enhanced FOXP3 expression.
T13454 3543-3624 Sentence denotes Importantly, these concentrations were not sufficient to induce GATA3 expression.
T13455 3625-3745 Sentence denotes IL-4 may favor proliferation of nTreg cells [47] or directly regulate FOXP3 expression in a STAT-dependent fashion [51].
T13456 3746-3906 Sentence denotes Since IL-13 does not effectively reduce FOXP3 and fails to induce GATA3, we hypothesized that the IL-4–dependent inhibition of FOXP3 could be mediated by GATA3.
T13457 3907-4046 Sentence denotes In fact, GATA3-inducing IL-4 concentrations repressed TGF-β–mediated FOXP3 expression, whereas IL-4 as well as TGF-β signaling were intact.
T13458 4047-4215 Sentence denotes This result suggested a competitive mechanism between GATA3 and FOXP3 transcription factors in determining lineage commitment during the early phase of differentiation.
T13459 4216-4318 Sentence denotes Accordingly, we investigated naturally high GATA3-expressing cells and confirmed the absence of FOXP3.
T13460 4319-4435 Sentence denotes Protein transduction of GATA3 into naive T cells inhibited FOXP3 induction in human, differentiating, naive T cells.
T13461 4436-4581 Sentence denotes This inhibitory effect of GATA3 was further confirmed in BALB/c transgenic mice, expressing GATA3 in T cells (DO11.10:CD2-GATA3 transgenic mice).
T13462 4582-4757 Sentence denotes In line with the transient overexpression of GATA3 in human T cells, cells of these mice failed to induce FOXP3 expression upon exposure with antigen in the presence of TGF-β.
T13463 4758-4915 Sentence denotes Strikingly, the DO11.10:CD2-GATA3 mice do have peripheral FOXP3+ cells, which however displayed a 10%–25% lower frequency compared to wild-type DO11.10 mice.
T13464 4916-5057 Sentence denotes Thus GATA3 restrains the development of certain Treg subsets, presumably the inducible, peripheral population and not those of thymic origin.
T13465 5058-5187 Sentence denotes Thymic T cells undergo a different maturation process, which may explain the insensitivity of nTreg to GATA3 overexpression [52].
T13466 5188-5558 Sentence denotes In contrast to the Th2-differentiating and iTreg-inhibiting function of GATA3 in peripheral T cells, GATA3 acts in the thymus together with other transcription factors such as the Repressor of GATA3 (ROG) in the differentiation process toward CD8 cells [53,54] or participates in complex transcriptional feedback network to regulate sympathoadrenal differentiation [55].
T13467 5559-5644 Sentence denotes Therefore, the role of GATA3 appears to be tissue specific and cannot be generalized.
T13468 5645-5755 Sentence denotes Our study demonstrates that GATA3 repressed FOXP3 expression directly by binding to the FOXP3 promoter region.
T13469 5756-5911 Sentence denotes A palindromic GATA-site is located 303 bp upstream of the TSS in a highly conserved region, which we have previously identified as the FOXP3 promoter [24].
T13470 5912-6183 Sentence denotes Site-specific mutation of this site increased the activity of the promoter constructs, thus revealing the repressive nature of this GATA element in memory T cells, which naturally express GATA3, whereas no difference was seen in naive T cells, which do not express GATA3.
T13471 6184-6277 Sentence denotes This palindromic GATA element is bound by GATA3 protein as proven with pull-down experiments.
T13472 6278-6362 Sentence denotes Furthermore, it is shown by ChIP that GATA3 binds this element also in intact cells.
T13473 6363-6570 Sentence denotes It is known that GATA3 can induce transcription by chromatin remodeling [56], by directly transactivating promoters [36], or, as shown in the current study, acts as a repressor of gene expression [21,57–59].
T13474 6571-6677 Sentence denotes Therefore keeping GATA3 expression low might be required to induce efficient FOXP3+ iTreg cell generation.
T13475 6678-6967 Sentence denotes The molecular interactions enabling GATA3 to inhibit FOXP3 are not identified yet, but the GATA-binding site is located adjacent to positive, inducing sites, composed of AP-1-NFATc2 sites [24], and GATA3 may compete with the binding of AP-1/NFAT to the promoter (unpublished observations).
T13476 6968-7057 Sentence denotes In summary, we demonstrated that FOXP3 is negatively regulated by cytokines such as IL-4.
T13477 7058-7231 Sentence denotes GATA3 acts as an inhibitor of FOXP3 expression in early T cell differentiation, as well as in differentiated Th2 cells by directly binding and repressing the FOXP3 promoter.
T13478 7232-7340 Sentence denotes We therefore describe a new mechanism of how Il-4 avoids tolerance induction by repressing FOXP3 expression.
T13479 7341-7532 Sentence denotes These findings will give new perspectives toward understanding molecular mechanisms of iTreg induction and thus pathways of peripheral tolerance induction, particularly in allergy and asthma.
T209 0-10 Sentence denotes Discussion
T210 11-182 Sentence denotes The current study reveals that FOXP3 induction, an important step in iTreg commitment, is inhibited by GATA3, which is the key regulator for polarization toward Th2 cells.
T211 183-285 Sentence denotes After differentiation, the effector Th2 cells become refractory to conversion into a FOXP3+ phenotype.
T212 286-389 Sentence denotes In accordance with other studies, we found that CD4+CD25– cells were able to up-regulate FOXP3 [12,27].
T213 390-586 Sentence denotes Already-committed cells such as memory T cells and Th1 cells showed only moderate and transient FOXP3 induction, which is not sufficient to change the phenotype toward a regulatory T cell profile.
T214 587-883 Sentence denotes In contrast, naive T cells could efficiently up-regulate FOXP3 when treated with TGF-β to induce iTreg cells [10,28–34], suggesting that FOXP3 plays an important role in the early differentiation process and may act in a way similar to that known for the Th1/Th2 decision factors T-bet and GATA3.
T215 884-1140 Sentence denotes This commitment is characterized by competitive expression of these factors [35,36], which we also observed in differentiating FOXP3+ iTreg cells including a phase of co-expression, which turns into nonoverlapping expression upon completed differentiation.
T216 1141-1294 Sentence denotes In this competitive process TGF-β appeared to be mandatory for the induction of FOXP3, possibly by keeping the expression of GATA3 and T-bet low [37,38].
T217 1295-1574 Sentence denotes In contrast, differentiating naive T cells in the absence of polarization factors (Th0) such as IL-4, IL-12, or TGF-β showed only a transient FOXP3 expression and failed to generate a population of FOXP3-expressing cells, but GATA3 and T-bet were up-regulated (unpublished data).
T218 1575-1772 Sentence denotes Interestingly, as we and others previously described, FOXP3-promoting factors, such as dexamethasone [39], CTLA-4 [40], and estrogens [41], are also known as inhibitors of GATA3 expression [42–45].
T219 1773-1904 Sentence denotes Therefore GATA3 not only induces differentiation into Th2 cells but also inhibits FOXP3 expression and commitment into iTreg cells.
T220 1905-2076 Sentence denotes The Th2 cytokine IL-4 but not IL-13 (unpublished data) was able to inhibit TGF-β–mediated FOXP3 induction and therefore prevented conversion into the regulatory phenotype.
T221 2077-2205 Sentence denotes To prove the inhibitory effect of IL-4 on inducible or natural Treg commitment in vivo, we treated mice with IL-4 and anti-IL-4.
T222 2206-2278 Sentence denotes This has been shown to increase the effect of the cytokine in vivo [19].
T223 2279-2421 Sentence denotes Only the IL-4/IL-4 mAb complex resulted in a decrease of the amount of natural or inducible Treg (CD25+ and Foxp3+) cells 7 d after treatment.
T224 2422-2531 Sentence denotes Our results suggest that IL-4 is only interfering with the differentiation of naive T cells into iTreg cells.
T225 2532-2844 Sentence denotes But since a distinction of nTreg and iTreg cells is currently not possible, because iTreg cells also transiently express CD25 after activation, we cannot exclude that IL-4 may also inhibit Foxp3 expression in nTreg cells in vivo or that additional effects may contribute to the observed drop in Foxp3 expression.
T226 2845-2984 Sentence denotes IL-4 has already been shown to negatively regulate the development of naive T cells into Th1 or the IL-17–producing T cells (Th17) [46,47].
T227 2985-3187 Sentence denotes Similar effects have been recently described for IL-6, which, combined with TGF-β, inhibits the generation of iTreg cells and induces differentiation into the Th17 cells by an unknown mechanism [48,49].
T228 3188-3291 Sentence denotes Thus the polarization into iTreg cells is negatively regulated by the effector cytokines IL-4 and IL-6.
T229 3292-3391 Sentence denotes IL-4 has been previously shown to induce the generation of FOXP3+ Treg cells out of CD4+CD25– [50].
T230 3392-3542 Sentence denotes In those experiments, the concentrations of IL-4 used were low, and as we also observed, IL-4 at low concentration slightly enhanced FOXP3 expression.
T231 3543-3624 Sentence denotes Importantly, these concentrations were not sufficient to induce GATA3 expression.
T232 3625-3745 Sentence denotes IL-4 may favor proliferation of nTreg cells [47] or directly regulate FOXP3 expression in a STAT-dependent fashion [51].
T233 3746-3906 Sentence denotes Since IL-13 does not effectively reduce FOXP3 and fails to induce GATA3, we hypothesized that the IL-4–dependent inhibition of FOXP3 could be mediated by GATA3.
T234 3907-4046 Sentence denotes In fact, GATA3-inducing IL-4 concentrations repressed TGF-β–mediated FOXP3 expression, whereas IL-4 as well as TGF-β signaling were intact.
T235 4047-4215 Sentence denotes This result suggested a competitive mechanism between GATA3 and FOXP3 transcription factors in determining lineage commitment during the early phase of differentiation.
T236 4216-4318 Sentence denotes Accordingly, we investigated naturally high GATA3-expressing cells and confirmed the absence of FOXP3.
T237 4319-4435 Sentence denotes Protein transduction of GATA3 into naive T cells inhibited FOXP3 induction in human, differentiating, naive T cells.
T238 4436-4581 Sentence denotes This inhibitory effect of GATA3 was further confirmed in BALB/c transgenic mice, expressing GATA3 in T cells (DO11.10:CD2-GATA3 transgenic mice).
T239 4582-4757 Sentence denotes In line with the transient overexpression of GATA3 in human T cells, cells of these mice failed to induce FOXP3 expression upon exposure with antigen in the presence of TGF-β.
T240 4758-4915 Sentence denotes Strikingly, the DO11.10:CD2-GATA3 mice do have peripheral FOXP3+ cells, which however displayed a 10%–25% lower frequency compared to wild-type DO11.10 mice.
T241 4916-5057 Sentence denotes Thus GATA3 restrains the development of certain Treg subsets, presumably the inducible, peripheral population and not those of thymic origin.
T242 5058-5187 Sentence denotes Thymic T cells undergo a different maturation process, which may explain the insensitivity of nTreg to GATA3 overexpression [52].
T243 5188-5558 Sentence denotes In contrast to the Th2-differentiating and iTreg-inhibiting function of GATA3 in peripheral T cells, GATA3 acts in the thymus together with other transcription factors such as the Repressor of GATA3 (ROG) in the differentiation process toward CD8 cells [53,54] or participates in complex transcriptional feedback network to regulate sympathoadrenal differentiation [55].
T244 5559-5644 Sentence denotes Therefore, the role of GATA3 appears to be tissue specific and cannot be generalized.
T245 5645-5755 Sentence denotes Our study demonstrates that GATA3 repressed FOXP3 expression directly by binding to the FOXP3 promoter region.
T246 5756-5911 Sentence denotes A palindromic GATA-site is located 303 bp upstream of the TSS in a highly conserved region, which we have previously identified as the FOXP3 promoter [24].
T247 5912-6183 Sentence denotes Site-specific mutation of this site increased the activity of the promoter constructs, thus revealing the repressive nature of this GATA element in memory T cells, which naturally express GATA3, whereas no difference was seen in naive T cells, which do not express GATA3.
T248 6184-6277 Sentence denotes This palindromic GATA element is bound by GATA3 protein as proven with pull-down experiments.
T249 6278-6362 Sentence denotes Furthermore, it is shown by ChIP that GATA3 binds this element also in intact cells.
T250 6363-6570 Sentence denotes It is known that GATA3 can induce transcription by chromatin remodeling [56], by directly transactivating promoters [36], or, as shown in the current study, acts as a repressor of gene expression [21,57–59].
T251 6571-6677 Sentence denotes Therefore keeping GATA3 expression low might be required to induce efficient FOXP3+ iTreg cell generation.
T252 6678-6967 Sentence denotes The molecular interactions enabling GATA3 to inhibit FOXP3 are not identified yet, but the GATA-binding site is located adjacent to positive, inducing sites, composed of AP-1-NFATc2 sites [24], and GATA3 may compete with the binding of AP-1/NFAT to the promoter (unpublished observations).
T253 6968-7057 Sentence denotes In summary, we demonstrated that FOXP3 is negatively regulated by cytokines such as IL-4.
T254 7058-7231 Sentence denotes GATA3 acts as an inhibitor of FOXP3 expression in early T cell differentiation, as well as in differentiated Th2 cells by directly binding and repressing the FOXP3 promoter.
T255 7232-7340 Sentence denotes We therefore describe a new mechanism of how Il-4 avoids tolerance induction by repressing FOXP3 expression.
T256 7341-7532 Sentence denotes These findings will give new perspectives toward understanding molecular mechanisms of iTreg induction and thus pathways of peripheral tolerance induction, particularly in allergy and asthma.

ICD10

Id Subject Object Predicate Lexical cue
T16682 7513-7520 http://purl.bioontology.org/ontology/ICD10/T78.4 denotes allergy
T16683 7525-7531 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T16684 7525-7531 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T17339 42-47 Protein denotes FOXP3
T17340 48-57 Positive_regulation denotes induction
T17341 101-110 Negative_regulation denotes inhibited
T17342 114-119 Protein denotes GATA3
T17343 268-273 Protein denotes FOXP3
T17344 334-337 Protein denotes CD4
T17345 338-342 Protein denotes CD25
T17346 363-374 Positive_regulation denotes up-regulate
T17347 375-380 Protein denotes FOXP3
T17348 486-491 Protein denotes FOXP3
T17349 492-501 Positive_regulation denotes induction
T17350 632-643 Positive_regulation denotes up-regulate
T17351 644-649 Protein denotes FOXP3
T17352 668-673 Protein denotes TGF-β
T17353 724-729 Protein denotes FOXP3
T17354 867-872 Protein denotes T-bet
T17355 877-882 Protein denotes GATA3
T17356 932-942 Gene_expression denotes expression
T17357 932-942 Gene_expression denotes expression
T17358 1011-1016 Protein denotes FOXP3
T17359 1051-1064 Gene_expression denotes co-expression
T17360 1051-1064 Gene_expression denotes co-expression
T17361 1098-1108 Gene_expression denotes expression
T17362 1098-1108 Gene_expression denotes expression
T17363 1169-1174 Protein denotes TGF-β
T17364 1221-1226 Protein denotes FOXP3
T17365 1252-1262 Gene_expression denotes expression
T17366 1252-1262 Gene_expression denotes expression
T17367 1266-1271 Protein denotes GATA3
T17368 1276-1281 Protein denotes T-bet
T17369 1282-1285 Negative_regulation denotes low true
T17370 1282-1285 Negative_regulation denotes low true
T17371 1345-1352 Negative_regulation denotes absence
T17372 1345-1352 Negative_regulation denotes absence
T17373 1345-1352 Negative_regulation denotes absence
T17374 1391-1395 Protein denotes IL-4
T17375 1397-1402 Protein denotes IL-12
T17376 1407-1412 Protein denotes TGF-β
T17377 1437-1442 Protein denotes FOXP3
T17378 1443-1453 Gene_expression denotes expression
T17379 1493-1498 Protein denotes FOXP3
T17380 1499-1509 Gene_expression denotes expressing
T17381 1521-1526 Protein denotes GATA3
T17382 1531-1536 Protein denotes T-bet
T17383 1542-1554 Positive_regulation denotes up-regulated
T17384 1542-1554 Positive_regulation denotes up-regulated
T17385 1629-1634 Protein denotes FOXP3
T17386 1635-1644 Positive_regulation denotes promoting
T17387 1682-1688 Protein denotes CTLA-4
T17388 1733-1743 Negative_regulation denotes inhibitors
T17389 1747-1752 Protein denotes GATA3
T17390 1753-1763 Gene_expression denotes expression
T17391 1783-1788 Protein denotes GATA3
T17392 1846-1854 Negative_regulation denotes inhibits
T17393 1855-1860 Protein denotes FOXP3
T17394 1861-1871 Gene_expression denotes expression
T17395 1922-1926 Protein denotes IL-4
T17396 1935-1940 Protein denotes IL-13
T17397 1972-1979 Negative_regulation denotes inhibit
T17398 1972-1979 Negative_regulation denotes inhibit true
T17399 1980-1985 Protein denotes TGF-β
T17400 1995-2000 Protein denotes FOXP3
T17401 2001-2010 Positive_regulation denotes induction
T17402 2111-2115 Protein denotes IL-4
T17403 2186-2190 Protein denotes IL-4
T17404 2200-2204 Protein denotes IL-4
T17405 2288-2292 Protein denotes IL-4
T17406 2293-2297 Protein denotes IL-4
T17407 2377-2381 Protein denotes CD25
T17408 2387-2392 Protein denotes Foxp3
T17409 2447-2451 Protein denotes IL-4
T17410 2645-2652 Gene_expression denotes express
T17411 2653-2657 Protein denotes CD25
T17412 2699-2703 Protein denotes IL-4
T17413 2713-2720 Negative_regulation denotes inhibit true
T17414 2721-2726 Protein denotes Foxp3
T17415 2727-2737 Gene_expression denotes expression
T17416 2792-2802 Positive_regulation denotes contribute true
T17417 2819-2823 Negative_regulation denotes drop
T17418 2827-2832 Protein denotes Foxp3
T17419 2833-2843 Gene_expression denotes expression
T17420 2845-2849 Protein denotes IL-4
T17421 2945-2950 Protein denotes IL-17
T17422 2951-2960 Gene_expression denotes producing
T17423 3034-3038 Protein denotes IL-6
T17424 3061-3066 Protein denotes TGF-β
T17425 3277-3281 Protein denotes IL-4
T17426 3286-3290 Protein denotes IL-6
T17427 3292-3296 Protein denotes IL-4
T17428 3351-3356 Protein denotes FOXP3
T17429 3376-3379 Protein denotes CD4
T17430 3380-3384 Protein denotes CD25
T17431 3436-3440 Protein denotes IL-4
T17432 3481-3485 Protein denotes IL-4
T17433 3516-3524 Positive_regulation denotes enhanced
T17434 3525-3530 Protein denotes FOXP3
T17435 3531-3541 Gene_expression denotes expression
T17436 3600-3606 Positive_regulation denotes induce true
T17437 3607-3612 Protein denotes GATA3
T17438 3613-3623 Gene_expression denotes expression
T17439 3625-3629 Protein denotes IL-4
T17440 3686-3694 Regulation denotes regulate true
T17441 3695-3700 Protein denotes FOXP3
T17442 3701-3711 Gene_expression denotes expression
T17443 3752-3757 Protein denotes IL-13
T17444 3779-3785 Negative_regulation denotes reduce true
T17445 3786-3791 Protein denotes FOXP3
T17446 3805-3811 Positive_regulation denotes induce true
T17447 3812-3817 Protein denotes GATA3
T17448 3844-3848 Protein denotes IL-4
T17449 3859-3869 Negative_regulation denotes inhibition
T17450 3873-3878 Protein denotes FOXP3
T17451 3888-3896 Positive_regulation denotes mediated true
T17452 3900-3905 Protein denotes GATA3
T17453 3916-3921 Protein denotes GATA3
T17454 3922-3930 Positive_regulation denotes inducing
T17455 3931-3935 Protein denotes IL-4
T17456 3951-3960 Negative_regulation denotes repressed
T17457 3961-3966 Protein denotes TGF-β
T17458 3967-3975 Positive_regulation denotes mediated
T17459 3976-3981 Protein denotes FOXP3
T17460 3982-3992 Gene_expression denotes expression
T17461 4002-4006 Protein denotes IL-4
T17462 4018-4023 Protein denotes TGF-β
T17463 4101-4106 Protein denotes GATA3
T17464 4111-4116 Protein denotes FOXP3
T17465 4255-4259 Positive_regulation denotes high
T17466 4260-4265 Protein denotes GATA3
T17467 4266-4276 Gene_expression denotes expressing
T17468 4301-4308 Negative_regulation denotes absence
T17469 4312-4317 Protein denotes FOXP3
T17470 4343-4348 Protein denotes GATA3
T17471 4368-4377 Negative_regulation denotes inhibited
T17472 4378-4383 Protein denotes FOXP3
T17473 4384-4393 Positive_regulation denotes induction
T17474 4462-4467 Protein denotes GATA3
T17475 4517-4527 Gene_expression denotes expressing
T17476 4528-4533 Protein denotes GATA3
T17477 4554-4557 Protein denotes CD2
T17478 4558-4563 Protein denotes GATA3
T17479 4609-4623 Positive_regulation denotes overexpression
T17480 4627-4632 Protein denotes GATA3
T17481 4671-4677 Negative_regulation denotes failed
T17482 4681-4687 Positive_regulation denotes induce
T17483 4688-4693 Protein denotes FOXP3
T17484 4694-4704 Gene_expression denotes expression
T17485 4751-4756 Protein denotes TGF-β
T17486 4782-4785 Protein denotes CD2
T17487 4786-4791 Protein denotes GATA3
T17488 4816-4821 Protein denotes FOXP3
T17489 4921-4926 Protein denotes GATA3
T17490 5161-5166 Protein denotes GATA3
T17491 5167-5181 Positive_regulation denotes overexpression
T17492 5260-5265 Protein denotes GATA3
T17493 5289-5294 Protein denotes GATA3
T17494 5368-5386 Protein denotes Repressor of GATA3
T17495 5388-5391 Protein denotes ROG
T17496 5431-5434 Protein denotes CD8
T17497 5582-5587 Protein denotes GATA3
T17498 5673-5678 Protein denotes GATA3
T17499 5679-5688 Negative_regulation denotes repressed
T17500 5689-5694 Protein denotes FOXP3
T17501 5695-5705 Gene_expression denotes expression
T17502 5718-5725 Binding denotes binding
T17503 5733-5738 Protein denotes FOXP3
T17504 5739-5754 Entity denotes promoter region
T17505 5891-5896 Protein denotes FOXP3
T17506 6092-6099 Gene_expression denotes express
T17507 6100-6105 Protein denotes GATA3
T17508 6169-6176 Gene_expression denotes express true
T17509 6177-6182 Protein denotes GATA3
T17510 6217-6222 Binding denotes bound
T17511 6226-6231 Protein denotes GATA3
T17512 6316-6321 Protein denotes GATA3
T17513 6322-6327 Binding denotes binds
T17514 6380-6385 Protein denotes GATA3
T17515 6589-6594 Protein denotes GATA3
T17516 6595-6605 Gene_expression denotes expression
T17517 6606-6609 Negative_regulation denotes low
T17518 6648-6653 Protein denotes FOXP3
T17519 6714-6719 Protein denotes GATA3
T17520 6723-6730 Negative_regulation denotes inhibit
T17521 6731-6736 Protein denotes FOXP3
T17522 6876-6881 Protein denotes GATA3
T17523 6886-6893 Negative_regulation denotes compete true
T17524 6886-6893 Negative_regulation denotes compete true
T17525 6903-6910 Binding denotes binding
T17526 6903-6910 Binding denotes binding
T17527 6914-6918 Protein denotes AP-1
T17528 6919-6923 Protein denotes NFAT
T17529 6931-6939 Entity denotes promoter
T17530 7001-7006 Protein denotes FOXP3
T17531 7010-7030 Negative_regulation denotes negatively regulated
T17532 7052-7056 Protein denotes IL-4
T17533 7058-7063 Protein denotes GATA3
T17534 7064-7084 Negative_regulation denotes acts as an inhibitor
T17535 7088-7093 Protein denotes FOXP3
T17536 7094-7104 Gene_expression denotes expression
T17537 7189-7196 Binding denotes binding
T17538 7201-7211 Negative_regulation denotes repressing
T17539 7216-7221 Protein denotes FOXP3
T17540 7222-7230 Entity denotes promoter
T17541 7277-7281 Protein denotes Il-4
T17542 7312-7322 Negative_regulation denotes repressing
T17543 7323-7328 Protein denotes FOXP3
T17544 7329-7339 Gene_expression denotes expression
R13155 T17339 T17340 themeOf FOXP3,induction
R13156 T17340 T17341 themeOf induction,inhibited
R13157 T17342 T17341 causeOf GATA3,inhibited
R13160 T17347 T17346 themeOf FOXP3,up-regulate
R13161 T17348 T17349 themeOf FOXP3,induction
R13163 T17351 T17350 themeOf FOXP3,up-regulate
R13164 T17352 T17350 causeOf TGF-β,up-regulate
R13166 T17354 T17356 themeOf T-bet,expression
R13167 T17354 T17359 themeOf T-bet,co-expression
R13168 T17354 T17361 themeOf T-bet,expression
R13170 T17355 T17357 themeOf GATA3,expression
R13171 T17355 T17360 themeOf GATA3,co-expression
R13172 T17355 T17362 themeOf GATA3,expression
R13175 T17363 T17369 causeOf TGF-β,low
R13176 T17363 T17370 causeOf TGF-β,low
R13177 T17365 T17369 themeOf expression,low
R13178 T17366 T17370 themeOf expression,low
R13179 T17367 T17365 themeOf GATA3,expression
R13181 T17368 T17366 themeOf T-bet,expression
R13184 T17374 T17371 themeOf IL-4,absence
R13185 T17375 T17372 themeOf IL-12,absence
R13186 T17376 T17373 themeOf TGF-β,absence
R13187 T17377 T17378 themeOf FOXP3,expression
R13188 T17379 T17380 themeOf FOXP3,expressing
R13190 T17381 T17383 themeOf GATA3,up-regulated
R13191 T17382 T17384 themeOf T-bet,up-regulated
R13193 T17385 T17386 themeOf FOXP3,promoting
R13195 T17387 T17386 causeOf CTLA-4,promoting
R13196 T17387 T17388 causeOf CTLA-4,inhibitors
R13198 T17389 T17390 themeOf GATA3,expression
R13199 T17390 T17388 themeOf expression,inhibitors
R13206 T17396 T17398 causeOf IL-13,inhibit
R13208 T17399 T17401 causeOf TGF-β,induction
R13209 T17400 T17401 themeOf FOXP3,induction
R13210 T17401 T17397 themeOf induction,inhibit
R13211 T17401 T17398 themeOf induction,inhibit
R13213 T17455 T17454 themeOf IL-4,inducing
R13214 T17457 T17458 causeOf TGF-β,mediated
R13215 T17410 T17413 causeOf express,inhibit
R13216 T17411 T17410 themeOf CD25,express
R13217 T17414 T17415 themeOf Foxp3,expression
R13218 T17458 T17456 themeOf mediated,repressed
R13219 T17415 T17413 themeOf expression,inhibit
R13220 T17417 T17416 themeOf drop,contribute
R13221 T17459 T17460 themeOf FOXP3,expression
R13222 T17418 T17419 themeOf Foxp3,expression
R13223 T17419 T17417 themeOf expression,drop
R13224 T17460 T17458 themeOf expression,mediated
R13225 T17421 T17422 themeOf IL-17,producing
R13226 T17466 T17467 themeOf GATA3,expressing
R13227 T17467 T17465 themeOf expressing,high
R13228 T17432 T17433 causeOf IL-4,enhanced
R13229 T17432 T17436 causeOf IL-4,induce
R13230 T17469 T17468 themeOf FOXP3,absence
R13231 T17434 T17435 themeOf FOXP3,expression
R13232 T17435 T17433 themeOf expression,enhanced
R13233 T17437 T17438 themeOf GATA3,expression
R13234 T17470 T17471 causeOf GATA3,inhibited
R13235 T17438 T17436 themeOf expression,induce
R13236 T17472 T17473 themeOf FOXP3,induction
R13237 T17441 T17442 themeOf FOXP3,expression
R13238 T17442 T17440 themeOf expression,regulate
R13239 T17443 T17444 causeOf IL-13,reduce
R13240 T17443 T17446 causeOf IL-13,induce
R13241 T17445 T17444 themeOf FOXP3,reduce
R13242 T17447 T17446 themeOf GATA3,induce
R13243 T17473 T17471 themeOf induction,inhibited
R13244 T17448 T17449 causeOf IL-4,inhibition
R13245 T17449 T17451 themeOf inhibition,mediated
R13246 T17450 T17449 themeOf FOXP3,inhibition
R13247 T17476 T17475 themeOf GATA3,expressing
R13248 T17452 T17451 causeOf GATA3,mediated
R13249 T17453 T17454 causeOf GATA3,inducing
R13250 T17454 T17456 causeOf inducing,repressed
R13251 T17479 T17481 causeOf overexpression,failed
R13252 T17480 T17479 themeOf GATA3,overexpression
R13253 T17482 T17481 themeOf induce,failed
R13254 T17495 T17494 equivalentTo ROG,Repressor of GATA3
R13255 T17498 T17502 themeOf GATA3,binding
R13256 T17483 T17484 themeOf FOXP3,expression
R13257 T17500 T17501 themeOf FOXP3,expression
R13258 T17501 T17499 themeOf expression,repressed
R13259 T17484 T17482 themeOf expression,induce
R13260 T17502 T17499 causeOf binding,repressed
R13261 T17490 T17491 themeOf GATA3,overexpression
R13262 T17504 T17502 themeOf promoter region,binding
R13263 T17504 T17503 partOf promoter region,FOXP3
R13264 T17507 T17506 themeOf GATA3,express
R13265 T17509 T17508 themeOf GATA3,express
R13266 T17511 T17510 themeOf GATA3,bound
R13267 T17536 T17534 themeOf expression,acts as an inhibitor
R13268 T17512 T17513 themeOf GATA3,binds
R13269 T17540 T17537 themeOf promoter,binding
R13270 T17515 T17516 themeOf GATA3,expression
R13271 T17516 T17517 themeOf expression,low
R13272 T17519 T17520 causeOf GATA3,inhibit
R13273 T17540 T17539 partOf promoter,FOXP3
R13274 T17521 T17520 themeOf FOXP3,inhibit
R13275 T17540 T17538 themeOf promoter,repressing
R13276 T17522 T17523 causeOf GATA3,compete
R13277 T17522 T17524 causeOf GATA3,compete
R13278 T17541 T17542 causeOf Il-4,repressing
R13279 T17525 T17523 themeOf binding,compete
R13280 T17543 T17544 themeOf FOXP3,expression
R13281 T17526 T17524 themeOf binding,compete
R13282 T17527 T17525 themeOf AP-1,binding
R13283 T17528 T17526 themeOf NFAT,binding
R13284 T17529 T17525 themeOf promoter,binding
R13285 T17529 T17521 partOf promoter,FOXP3
R13286 T17529 T17526 themeOf promoter,binding
R13287 T17530 T17531 themeOf FOXP3,negatively regulated
R13288 T17544 T17542 themeOf expression,repressing
R13289 T17532 T17531 causeOf IL-4,negatively regulated
R13290 T17533 T17534 causeOf GATA3,acts as an inhibitor
R13291 T17533 T17537 themeOf GATA3,binding
R13292 T17533 T17538 causeOf GATA3,repressing
R13293 T17535 T17536 themeOf FOXP3,expression
R13201 T17391 T17392 causeOf GATA3,inhibits
R13202 T17393 T17394 themeOf FOXP3,expression
R13204 T17394 T17392 themeOf expression,inhibits
R13205 T17395 T17397 causeOf IL-4,inhibit

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T13498 48-57 Positive_regulation denotes induction
T13499 1098-1108 Gene_expression denotes expression
T13500 1098-1108 Gene_expression denotes expression
T13501 1252-1262 Gene_expression denotes expression
T13502 1252-1262 Gene_expression denotes expression
T13503 1282-1285 Negative_regulation denotes low true
T13504 1282-1285 Negative_regulation denotes low true
T13505 1345-1352 Negative_regulation denotes absence
T13506 1345-1352 Negative_regulation denotes absence
T13507 1345-1352 Negative_regulation denotes absence
T13508 1443-1453 Gene_expression denotes expression
T13509 101-110 Negative_regulation denotes inhibited
T13510 1499-1509 Gene_expression denotes expressing
T13511 1542-1554 Positive_regulation denotes up-regulated
T13512 1542-1554 Positive_regulation denotes up-regulated
T13513 1635-1644 Positive_regulation denotes promoting
T13514 1733-1743 Negative_regulation denotes inhibitors
T13515 1753-1763 Gene_expression denotes expression
T13516 1846-1854 Negative_regulation denotes inhibits
T13517 1861-1871 Gene_expression denotes expression
T13518 1972-1979 Negative_regulation denotes inhibit
T13519 2001-2010 Positive_regulation denotes induction
T13520 363-374 Positive_regulation denotes up-regulate
T13521 1972-1979 Negative_regulation denotes inhibit true
T13522 2645-2652 Gene_expression denotes express
T13523 2713-2720 Negative_regulation denotes inhibit true
T13524 2727-2737 Gene_expression denotes expression
T13525 2792-2802 Positive_regulation denotes contribute true
T13526 2819-2823 Negative_regulation denotes drop
T13527 2833-2843 Gene_expression denotes expression
T13528 2951-2960 Gene_expression denotes producing
T13529 3516-3524 Positive_regulation denotes enhanced
T13530 3531-3541 Gene_expression denotes expression
T13531 492-501 Positive_regulation denotes induction
T13532 3600-3606 Positive_regulation denotes induce true
T13533 3613-3623 Gene_expression denotes expression
T13534 3686-3694 Regulation denotes regulate true
T13535 3701-3711 Gene_expression denotes expression
T13536 3779-3785 Negative_regulation denotes reduce true
T13537 3805-3811 Positive_regulation denotes induce true
T13538 3859-3869 Negative_regulation denotes inhibition
T13539 3888-3896 Positive_regulation denotes mediated true
T13540 3922-3930 Positive_regulation denotes inducing
T13541 3951-3960 Negative_regulation denotes repressed
T13542 632-643 Positive_regulation denotes up-regulate
T13543 3967-3975 Positive_regulation denotes mediated
T13544 3982-3992 Gene_expression denotes expression
T13545 4255-4259 Positive_regulation denotes high
T13546 4266-4276 Gene_expression denotes expressing
T13547 4301-4308 Negative_regulation denotes absence
T13548 4368-4377 Negative_regulation denotes inhibited
T13549 4384-4393 Positive_regulation denotes induction
T13550 4517-4527 Gene_expression denotes expressing
T13551 4609-4623 Positive_regulation denotes overexpression
T13552 4671-4677 Negative_regulation denotes failed
T13553 932-942 Gene_expression denotes expression
T13554 4681-4687 Positive_regulation denotes induce
T13555 4694-4704 Gene_expression denotes expression
T13556 5167-5181 Positive_regulation denotes overexpression
T13557 5679-5688 Negative_regulation denotes repressed
T13558 5695-5705 Gene_expression denotes expression
T13559 5718-5725 Binding denotes binding
T13560 6092-6099 Gene_expression denotes express
T13561 6169-6176 Gene_expression denotes express true
T13562 6217-6222 Binding denotes bound
T13563 6322-6327 Binding denotes binds
T13564 932-942 Gene_expression denotes expression
T13565 6595-6605 Gene_expression denotes expression
T13566 6606-6609 Negative_regulation denotes low
T13567 6723-6730 Negative_regulation denotes inhibit
T13568 6886-6893 Negative_regulation denotes compete true
T13569 6903-6910 Binding denotes binding
T13570 6886-6893 Negative_regulation denotes compete true
T13571 6903-6910 Binding denotes binding
T13572 7010-7030 Negative_regulation denotes negatively regulated
T13573 7064-7084 Negative_regulation denotes acts as an inhibitor
T13574 7094-7104 Gene_expression denotes expression
T13575 1051-1064 Gene_expression denotes co-expression
T13576 7189-7196 Binding denotes binding
T13577 7201-7211 Negative_regulation denotes repressing
T13578 7312-7322 Negative_regulation denotes repressing
T13579 7329-7339 Gene_expression denotes expression
T13580 1051-1064 Gene_expression denotes co-expression
T13581 42-47 Protein denotes FOXP3
T13582 724-729 Protein denotes FOXP3
T13583 5733-5738 Protein denotes FOXP3
T13584 5891-5896 Protein denotes FOXP3
T13585 6100-6105 Protein denotes GATA3
T13586 6177-6182 Protein denotes GATA3
T13587 6226-6231 Protein denotes GATA3
T13588 6316-6321 Protein denotes GATA3
T13589 6380-6385 Protein denotes GATA3
T13590 6589-6594 Protein denotes GATA3
T13591 6648-6653 Protein denotes FOXP3
T13592 6714-6719 Protein denotes GATA3
T13593 867-872 Protein denotes T-bet
T13594 6731-6736 Protein denotes FOXP3
T13595 6876-6881 Protein denotes GATA3
T13596 6914-6918 Protein denotes AP-1
T13597 6919-6923 Protein denotes NFAT
T13598 7001-7006 Protein denotes FOXP3
T13599 7052-7056 Protein denotes IL-4
T13600 7058-7063 Protein denotes GATA3
T13601 7088-7093 Protein denotes FOXP3
T13602 7216-7221 Protein denotes FOXP3
T13603 7277-7281 Protein denotes Il-4
T13604 877-882 Protein denotes GATA3
T13605 7323-7328 Protein denotes FOXP3
T13606 1011-1016 Protein denotes FOXP3
T13607 1169-1174 Protein denotes TGF-β
T13608 1221-1226 Protein denotes FOXP3
T13609 1266-1271 Protein denotes GATA3
T13610 1276-1281 Protein denotes T-bet
T13611 1391-1395 Protein denotes IL-4
T13612 5739-5754 Entity denotes promoter region
T13613 1397-1402 Protein denotes IL-12
T13614 6931-6939 Entity denotes promoter
T13615 7222-7230 Entity denotes promoter
T13616 114-119 Protein denotes GATA3
T13617 1407-1412 Protein denotes TGF-β
T13618 1437-1442 Protein denotes FOXP3
T13619 1493-1498 Protein denotes FOXP3
T13620 1521-1526 Protein denotes GATA3
T13621 1531-1536 Protein denotes T-bet
T13622 1629-1634 Protein denotes FOXP3
T13623 1682-1688 Protein denotes CTLA-4
T13624 1747-1752 Protein denotes GATA3
T13625 1783-1788 Protein denotes GATA3
T13626 1855-1860 Protein denotes FOXP3
T13627 268-273 Protein denotes FOXP3
T13628 1922-1926 Protein denotes IL-4
T13629 1935-1940 Protein denotes IL-13
T13630 1995-2000 Protein denotes FOXP3
T13631 2111-2115 Protein denotes IL-4
T13632 2186-2190 Protein denotes IL-4
T13633 2200-2204 Protein denotes IL-4
T13634 2288-2292 Protein denotes IL-4
T13635 2293-2297 Protein denotes IL-4
T13636 2377-2381 Protein denotes CD25
T13637 334-337 Protein denotes CD4
T13638 2387-2392 Protein denotes Foxp3
T13639 2447-2451 Protein denotes IL-4
T13640 2653-2657 Protein denotes CD25
T13641 2699-2703 Protein denotes IL-4
T13642 2721-2726 Protein denotes Foxp3
T13643 2827-2832 Protein denotes Foxp3
T13644 2845-2849 Protein denotes IL-4
T13645 2945-2950 Protein denotes IL-17
T13646 3034-3038 Protein denotes IL-6
T13647 3061-3066 Protein denotes TGF-β
T13648 338-342 Protein denotes CD25
T13649 3277-3281 Protein denotes IL-4
T13650 3286-3290 Protein denotes IL-6
T13651 3292-3296 Protein denotes IL-4
T13652 3351-3356 Protein denotes FOXP3
T13653 3376-3379 Protein denotes CD4
T13654 3380-3384 Protein denotes CD25
T13655 3436-3440 Protein denotes IL-4
T13656 3481-3485 Protein denotes IL-4
T13657 3525-3530 Protein denotes FOXP3
T13658 3607-3612 Protein denotes GATA3
T13659 375-380 Protein denotes FOXP3
T13660 3625-3629 Protein denotes IL-4
T13661 3695-3700 Protein denotes FOXP3
T13662 3752-3757 Protein denotes IL-13
T13663 3786-3791 Protein denotes FOXP3
T13664 3812-3817 Protein denotes GATA3
T13665 3844-3848 Protein denotes IL-4
T13666 3873-3878 Protein denotes FOXP3
T13667 3900-3905 Protein denotes GATA3
T13668 3916-3921 Protein denotes GATA3
T13669 3931-3935 Protein denotes IL-4
T13670 486-491 Protein denotes FOXP3
T13671 3976-3981 Protein denotes FOXP3
T13672 4002-4006 Protein denotes IL-4
T13673 4018-4023 Protein denotes TGF-β
T13674 4101-4106 Protein denotes GATA3
T13675 4111-4116 Protein denotes FOXP3
T13676 4260-4265 Protein denotes GATA3
T13677 4312-4317 Protein denotes FOXP3
T13678 4343-4348 Protein denotes GATA3
T13679 4378-4383 Protein denotes FOXP3
T13680 644-649 Protein denotes FOXP3
T13681 4462-4467 Protein denotes GATA3
T13682 4528-4533 Protein denotes GATA3
T13683 4554-4557 Protein denotes CD2
T13684 4558-4563 Protein denotes GATA3
T13685 4627-4632 Protein denotes GATA3
T13686 4688-4693 Protein denotes FOXP3
T13687 4751-4756 Protein denotes TGF-β
T13688 4782-4785 Protein denotes CD2
T13689 4786-4791 Protein denotes GATA3
T13690 4816-4821 Protein denotes FOXP3
T13691 668-673 Protein denotes TGF-β
T13692 4921-4926 Protein denotes GATA3
T13693 5161-5166 Protein denotes GATA3
T13694 5260-5265 Protein denotes GATA3
T13695 5289-5294 Protein denotes GATA3
T13696 5368-5386 Protein denotes Repressor of GATA3
T13697 5388-5391 Protein denotes ROG
T13698 5431-5434 Protein denotes CD8
T13699 5582-5587 Protein denotes GATA3
T13700 5673-5678 Protein denotes GATA3
T13701 5689-5694 Protein denotes FOXP3
T13702 1980-1985 Protein denotes TGF-β
T13703 3961-3966 Protein denotes TGF-β
R9959 T13498 T13509 themeOf induction,inhibited
R9960 T13501 T13503 themeOf expression,low
R9961 T13502 T13504 themeOf expression,low
R9962 T13515 T13514 themeOf expression,inhibitors
R9963 T13517 T13516 themeOf expression,inhibits
R9964 T13519 T13518 themeOf induction,inhibit
R9965 T13519 T13521 themeOf induction,inhibit
R9966 T13522 T13523 causeOf express,inhibit
R9967 T13524 T13523 themeOf expression,inhibit
R9968 T13526 T13525 themeOf drop,contribute
R9969 T13527 T13526 themeOf expression,drop
R9970 T13530 T13529 themeOf expression,enhanced
R9971 T13533 T13532 themeOf expression,induce
R9972 T13535 T13534 themeOf expression,regulate
R9973 T13538 T13539 themeOf inhibition,mediated
R9986 T13571 T13570 themeOf binding,compete
R9987 T13574 T13573 themeOf expression,acts as an inhibitor
R9988 T13579 T13578 themeOf expression,repressing
R9996 T13593 T13553 themeOf T-bet,expression
R9997 T13593 T13575 themeOf T-bet,co-expression
R9998 T13593 T13499 themeOf T-bet,expression
R10001 T13595 T13570 causeOf GATA3,compete
R10002 T13596 T13569 themeOf AP-1,binding
R10003 T13597 T13571 themeOf NFAT,binding
R10004 T13598 T13572 themeOf FOXP3,negatively regulated
R10005 T13599 T13572 causeOf IL-4,negatively regulated
R10006 T13600 T13573 causeOf GATA3,acts as an inhibitor
R10007 T13600 T13576 themeOf GATA3,binding
R10008 T13600 T13577 causeOf GATA3,repressing
R10009 T13601 T13574 themeOf FOXP3,expression
R10010 T13603 T13578 causeOf Il-4,repressing
R10011 T13604 T13564 themeOf GATA3,expression
R10012 T13604 T13580 themeOf GATA3,co-expression
R10013 T13604 T13500 themeOf GATA3,expression
R10014 T13605 T13579 themeOf FOXP3,expression
R10015 T13607 T13503 causeOf TGF-β,low
R10016 T13607 T13504 causeOf TGF-β,low
R10017 T13609 T13501 themeOf GATA3,expression
R10018 T13610 T13502 themeOf T-bet,expression
R10019 T13611 T13505 themeOf IL-4,absence
R10022 T13613 T13506 themeOf IL-12,absence
R10023 T13614 T13569 themeOf promoter,binding
R10024 T13614 T13594 partOf promoter,FOXP3
R10025 T13614 T13571 themeOf promoter,binding
R10026 T13615 T13576 themeOf promoter,binding
R10027 T13615 T13602 partOf promoter,FOXP3
R10028 T13615 T13577 themeOf promoter,repressing
R10029 T13616 T13509 causeOf GATA3,inhibited
R10030 T13617 T13507 themeOf TGF-β,absence
R10031 T13618 T13508 themeOf FOXP3,expression
R10032 T13619 T13510 themeOf FOXP3,expressing
R10033 T13620 T13511 themeOf GATA3,up-regulated
R10034 T13621 T13512 themeOf T-bet,up-regulated
R10035 T13622 T13513 themeOf FOXP3,promoting
R10036 T13623 T13513 causeOf CTLA-4,promoting
R10037 T13623 T13514 causeOf CTLA-4,inhibitors
R10038 T13624 T13515 themeOf GATA3,expression
R10039 T13625 T13516 causeOf GATA3,inhibits
R10040 T13626 T13517 themeOf FOXP3,expression
R10041 T13628 T13518 causeOf IL-4,inhibit
R10042 T13629 T13521 causeOf IL-13,inhibit
R10043 T13630 T13519 themeOf FOXP3,induction
R10044 T13640 T13522 themeOf CD25,express
R10045 T13642 T13524 themeOf Foxp3,expression
R10046 T13643 T13527 themeOf Foxp3,expression
R10047 T13645 T13528 themeOf IL-17,producing
R10048 T13656 T13529 causeOf IL-4,enhanced
R10049 T13656 T13532 causeOf IL-4,induce
R10050 T13657 T13530 themeOf FOXP3,expression
R10051 T13658 T13533 themeOf GATA3,expression
R10052 T13659 T13520 themeOf FOXP3,up-regulate
R10053 T13661 T13535 themeOf FOXP3,expression
R10054 T13662 T13536 causeOf IL-13,reduce
R10055 T13662 T13537 causeOf IL-13,induce
R10056 T13663 T13536 themeOf FOXP3,reduce
R10057 T13664 T13537 themeOf GATA3,induce
R10058 T13665 T13538 causeOf IL-4,inhibition
R10059 T13666 T13538 themeOf FOXP3,inhibition
R10063 T13670 T13531 themeOf FOXP3,induction
R10069 T13680 T13542 themeOf FOXP3,up-regulate
R10073 T13691 T13542 causeOf TGF-β,up-regulate
R9984 T13565 T13566 themeOf expression,low
R9985 T13569 T13568 themeOf binding,compete
R9989 T13581 T13498 themeOf FOXP3,induction
R9990 T13585 T13560 themeOf GATA3,express
R9991 T13586 T13561 themeOf GATA3,express
R9992 T13587 T13562 themeOf GATA3,bound
R9993 T13588 T13563 themeOf GATA3,binds
R9994 T13590 T13565 themeOf GATA3,expression
R9995 T13592 T13567 causeOf GATA3,inhibit
R9999 T13594 T13567 themeOf FOXP3,inhibit
R10000 T13595 T13568 causeOf GATA3,compete
R9974 T13540 T13541 causeOf inducing,repressed
R9975 T13543 T13541 themeOf mediated,repressed
R9976 T13544 T13543 themeOf expression,mediated
R9977 T13546 T13545 themeOf expressing,high
R9978 T13549 T13548 themeOf induction,inhibited
R9979 T13551 T13552 causeOf overexpression,failed
R9980 T13554 T13552 themeOf induce,failed
R9981 T13555 T13554 themeOf expression,induce
R9982 T13558 T13557 themeOf expression,repressed
R9983 T13559 T13557 causeOf binding,repressed
R10020 T13612 T13559 themeOf promoter region,binding
R10021 T13612 T13583 partOf promoter region,FOXP3
R10060 T13667 T13539 causeOf GATA3,mediated
R10061 T13668 T13540 causeOf GATA3,inducing
R10062 T13669 T13540 themeOf IL-4,inducing
R10064 T13671 T13544 themeOf FOXP3,expression
R10065 T13676 T13546 themeOf GATA3,expressing
R10066 T13677 T13547 themeOf FOXP3,absence
R10067 T13678 T13548 causeOf GATA3,inhibited
R10068 T13679 T13549 themeOf FOXP3,induction
R10070 T13682 T13550 themeOf GATA3,expressing
R10071 T13685 T13551 themeOf GATA3,overexpression
R10072 T13686 T13555 themeOf FOXP3,expression
R10074 T13693 T13556 themeOf GATA3,overexpression
R10075 T13697 T13696 equivalentTo ROG,Repressor of GATA3
R10076 T13700 T13559 themeOf GATA3,binding
R10077 T13701 T13558 themeOf FOXP3,expression
R10078 T13702 T13519 causeOf TGF-β,induction
R10079 T13703 T13543 causeOf TGF-β,mediated

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T14975 42-47 Q9BZS1 denotes FOXP3
T14976 114-119 P23771 denotes GATA3
T14977 268-273 Q9BZS1 denotes FOXP3
T14978 334-337 P01730 denotes CD4
T14979 338-342 P01589 denotes CD25
T14980 355-359 P00519 denotes able
T14981 375-380 Q9BZS1 denotes FOXP3
T14982 486-491 Q9BZS1 denotes FOXP3
T14983 644-649 Q9BZS1 denotes FOXP3
T14984 668-673 P01137 denotes TGF-β
T14985 724-729 Q9BZS1 denotes FOXP3
T14986 867-872 Q9UL17 denotes T-bet
T14987 877-882 P23771 denotes GATA3
T14988 1011-1016 Q9BZS1 denotes FOXP3
T14989 1169-1174 P01137 denotes TGF-β
T14990 1221-1226 Q9BZS1 denotes FOXP3
T14991 1266-1271 P23771 denotes GATA3
T14992 1276-1281 Q9UL17 denotes T-bet
T14993 1391-1395 P05112 denotes IL-4
T14994 1397-1402 P29459 denotes IL-12
T14995 1397-1402 P29460 denotes IL-12
T14996 1407-1412 P01137 denotes TGF-β
T14997 1437-1442 Q9BZS1 denotes FOXP3
T14998 1493-1498 Q9BZS1 denotes FOXP3
T14999 1521-1526 P23771 denotes GATA3
T15000 1531-1536 Q9UL17 denotes T-bet
T15001 1629-1634 Q9BZS1 denotes FOXP3
T15002 1747-1752 P23771 denotes GATA3
T15003 1783-1788 P23771 denotes GATA3
T15004 1855-1860 Q9BZS1 denotes FOXP3
T15005 1922-1926 P05112 denotes IL-4
T15006 1935-1940 P35225 denotes IL-13
T15007 1964-1968 P00519 denotes able
T15008 1980-1985 P01137 denotes TGF-β
T15009 1995-2000 Q9BZS1 denotes FOXP3
T15010 2111-2115 P05112 denotes IL-4
T15011 2186-2190 P05112 denotes IL-4
T15012 2200-2204 P05112 denotes IL-4
T15013 2288-2292 P05112 denotes IL-4
T15014 2293-2297 P05112 denotes IL-4
T15015 2377-2381 P01589 denotes CD25
T15016 2387-2392 Q9BZS1 denotes Foxp3
T15017 2447-2451 P05112 denotes IL-4
T15018 2653-2657 P01589 denotes CD25
T15019 2699-2703 P05112 denotes IL-4
T15020 2721-2726 Q9BZS1 denotes Foxp3
T15021 2827-2832 Q9BZS1 denotes Foxp3
T15022 2845-2849 P05112 denotes IL-4
T15023 2945-2950 Q16552 denotes IL-17
T15024 3034-3038 P05231 denotes IL-6
T15025 3061-3066 P01137 denotes TGF-β
T15026 3277-3281 P05112 denotes IL-4
T15027 3286-3290 P05231 denotes IL-6
T15028 3292-3296 P05112 denotes IL-4
T15029 3351-3356 Q9BZS1 denotes FOXP3
T15030 3376-3379 P01730 denotes CD4
T15031 3380-3384 P01589 denotes CD25
T15032 3436-3440 P05112 denotes IL-4
T15033 3481-3485 P05112 denotes IL-4
T15034 3525-3530 Q9BZS1 denotes FOXP3
T15035 3607-3612 P23771 denotes GATA3
T15036 3625-3629 P05112 denotes IL-4
T15037 3695-3700 Q9BZS1 denotes FOXP3
T15038 3752-3757 P35225 denotes IL-13
T15039 3786-3791 Q9BZS1 denotes FOXP3
T15040 3812-3817 P23771 denotes GATA3
T15041 3844-3848 P05112 denotes IL-4
T15042 3873-3878 Q9BZS1 denotes FOXP3
T15043 3900-3905 P23771 denotes GATA3
T15044 3916-3921 P23771 denotes GATA3
T15045 3931-3935 P05112 denotes IL-4
T15046 3961-3966 P01137 denotes TGF-β
T15047 3976-3981 Q9BZS1 denotes FOXP3
T15048 4002-4006 P05112 denotes IL-4
T15049 4018-4023 P01137 denotes TGF-β
T15050 4101-4106 P23771 denotes GATA3
T15051 4111-4116 Q9BZS1 denotes FOXP3
T15052 4260-4265 P23771 denotes GATA3
T15053 4312-4317 Q9BZS1 denotes FOXP3
T15054 4343-4348 P23771 denotes GATA3
T15055 4378-4383 Q9BZS1 denotes FOXP3
T15056 4462-4467 P23771 denotes GATA3
T15057 4528-4533 P23771 denotes GATA3
T15058 4554-4557 P06729 denotes CD2
T15059 4558-4563 P23771 denotes GATA3
T15060 4627-4632 P23771 denotes GATA3
T15061 4688-4693 Q9BZS1 denotes FOXP3
T15062 4751-4756 P01137 denotes TGF-β
T15063 4782-4785 P06729 denotes CD2
T15064 4786-4791 P23771 denotes GATA3
T15065 4816-4821 Q9BZS1 denotes FOXP3
T15066 4921-4926 P23771 denotes GATA3
T15067 5161-5166 P23771 denotes GATA3
T15068 5260-5265 P23771 denotes GATA3
T15069 5289-5294 P23771 denotes GATA3
T15070 5381-5386 P23771 denotes GATA3
T15071 5431-5434 P01732 denotes CD8
T15072 5431-5434 P10966 denotes CD8
T15073 5582-5587 P23771 denotes GATA3
T15074 5673-5678 P23771 denotes GATA3
T15075 5689-5694 Q9BZS1 denotes FOXP3
T15076 5733-5738 Q9BZS1 denotes FOXP3
T15077 5891-5896 Q9BZS1 denotes FOXP3
T15078 6100-6105 P23771 denotes GATA3
T15079 6177-6182 P23771 denotes GATA3
T15080 6226-6231 P23771 denotes GATA3
T15081 6316-6321 P23771 denotes GATA3
T15082 6380-6385 P23771 denotes GATA3
T15083 6589-6594 P23771 denotes GATA3
T15084 6648-6653 Q9BZS1 denotes FOXP3
T15085 6714-6719 P23771 denotes GATA3
T15086 6731-6736 Q9BZS1 denotes FOXP3
T15087 6848-6852 P05412 denotes AP-1
T15088 6876-6881 P23771 denotes GATA3
T15089 6914-6918 P05412 denotes AP-1
T15090 7001-7006 Q9BZS1 denotes FOXP3
T15091 7052-7056 P05112 denotes IL-4
T15092 7058-7063 P23771 denotes GATA3
T15093 7088-7093 Q9BZS1 denotes FOXP3
T15094 7216-7221 Q9BZS1 denotes FOXP3
T15095 7277-7281 P05112 denotes Il-4
T15096 7323-7328 Q9BZS1 denotes FOXP3

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T13229 42-47 Protein denotes FOXP3
T13230 48-57 Positive_regulation denotes induction
T13231 101-110 Negative_regulation denotes inhibited
T13232 114-119 Protein denotes GATA3
T13233 268-273 Protein denotes FOXP3
T13234 334-337 Protein denotes CD4
T13235 338-342 Protein denotes CD25
T13236 363-374 Positive_regulation denotes up-regulate
T13237 375-380 Protein denotes FOXP3
T13238 486-491 Protein denotes FOXP3
T13239 492-501 Positive_regulation denotes induction
T13240 632-643 Positive_regulation denotes up-regulate
T13241 644-649 Protein denotes FOXP3
T13242 668-673 Protein denotes TGF-β true
T13243 724-729 Protein denotes FOXP3 true
T13244 867-872 Protein denotes T-bet
T13245 877-882 Protein denotes GATA3
T13246 1011-1016 Protein denotes FOXP3
T13247 1169-1174 Protein denotes TGF-β
T13248 1190-1199 Positive_regulation denotes mandatory
T13249 1208-1217 Positive_regulation denotes induction
T13250 1221-1226 Protein denotes FOXP3
T13251 1252-1262 Gene_expression denotes expression
T13252 1266-1271 Protein denotes GATA3
T13253 1276-1281 Protein denotes T-bet
T13254 1391-1395 Protein denotes IL-4
T13255 1397-1402 Protein denotes IL-12
T13256 1407-1412 Protein denotes TGF-β
T13257 1437-1442 Protein denotes FOXP3
T13258 1443-1453 Gene_expression denotes expression true
T13259 1493-1498 Protein denotes FOXP3
T13260 1499-1509 Gene_expression denotes expressing true
T13261 1521-1526 Protein denotes GATA3
T13262 1531-1536 Protein denotes T-bet true
T13263 1542-1554 Positive_regulation denotes up-regulated
T13264 1629-1634 Protein denotes FOXP3
T13265 1635-1644 Positive_regulation denotes promoting
T13266 1682-1688 Protein denotes CTLA-4
T13267 1733-1743 Negative_regulation denotes inhibitors
T13268 1747-1752 Protein denotes GATA3 true
T13269 1753-1763 Gene_expression denotes expression
T13270 1783-1788 Protein denotes GATA3 true
T13271 1846-1854 Negative_regulation denotes inhibits
T13272 1855-1860 Protein denotes FOXP3 true
T13273 1861-1871 Gene_expression denotes expression true
T13274 1922-1926 Protein denotes IL-4
T13275 1935-1940 Protein denotes IL-13 true
T13276 1972-1979 Negative_regulation denotes inhibit
T13277 1980-1985 Protein denotes TGF-β
T13278 1986-1994 Positive_regulation denotes mediated
T13279 1995-2000 Protein denotes FOXP3
T13280 2001-2010 Positive_regulation denotes induction
T13281 2111-2115 Protein denotes IL-4
T13282 2186-2190 Protein denotes IL-4
T13283 2200-2204 Protein denotes IL-4
T13284 2288-2292 Protein denotes IL-4
T13285 2293-2297 Protein denotes IL-4
T13286 2377-2381 Protein denotes CD25
T13287 2387-2392 Protein denotes Foxp3
T13288 2447-2451 Protein denotes IL-4
T13289 2645-2652 Gene_expression denotes express
T13290 2653-2657 Protein denotes CD25
T13291 2699-2703 Protein denotes IL-4
T13292 2713-2720 Negative_regulation denotes inhibit
T13293 2721-2726 Protein denotes Foxp3
T13294 2727-2737 Gene_expression denotes expression
T13295 2792-2802 Positive_regulation denotes contribute true
T13296 2819-2823 Negative_regulation denotes drop
T13297 2827-2832 Protein denotes Foxp3
T13298 2833-2843 Gene_expression denotes expression
T13299 2845-2849 Protein denotes IL-4
T13300 2945-2950 Protein denotes IL-17
T13301 2951-2960 Gene_expression denotes producing true
T13302 3034-3038 Protein denotes IL-6
T13303 3061-3066 Protein denotes TGF-β true
T13304 3241-3250 Regulation denotes regulated
T13305 3277-3281 Protein denotes IL-4
T13306 3286-3290 Protein denotes IL-6
T13307 3292-3296 Protein denotes IL-4
T13308 3351-3356 Protein denotes FOXP3
T13309 3376-3379 Protein denotes CD4
T13310 3380-3384 Protein denotes CD25
T13311 3436-3440 Protein denotes IL-4
T13312 3481-3485 Protein denotes IL-4
T13313 3516-3524 Positive_regulation denotes enhanced
T13314 3525-3530 Protein denotes FOXP3
T13315 3531-3541 Gene_expression denotes expression
T13316 3600-3606 Positive_regulation denotes induce
T13317 3607-3612 Protein denotes GATA3
T13318 3613-3623 Gene_expression denotes expression
T13319 3625-3629 Protein denotes IL-4
T13320 3686-3694 Regulation denotes regulate
T13321 3695-3700 Protein denotes FOXP3
T13322 3701-3711 Gene_expression denotes expression
T13323 3752-3757 Protein denotes IL-13
T13324 3779-3785 Negative_regulation denotes reduce
T13325 3786-3791 Protein denotes FOXP3
T13326 3805-3811 Positive_regulation denotes induce
T13327 3812-3817 Protein denotes GATA3
T13328 3844-3848 Protein denotes IL-4
T13329 3849-3858 Regulation denotes dependent
T13330 3859-3869 Negative_regulation denotes inhibition
T13331 3873-3878 Protein denotes FOXP3
T13332 3888-3896 Positive_regulation denotes mediated
T13333 3900-3905 Protein denotes GATA3
T13334 3916-3921 Protein denotes GATA3
T13335 3922-3930 Positive_regulation denotes inducing
T13336 3931-3935 Protein denotes IL-4
T13337 3951-3960 Negative_regulation denotes repressed
T13338 3961-3966 Protein denotes TGF-β
T13339 3967-3975 Positive_regulation denotes mediated
T13340 3976-3981 Protein denotes FOXP3
T13341 3982-3992 Gene_expression denotes expression
T13342 4002-4006 Protein denotes IL-4
T13343 4018-4023 Protein denotes TGF-β
T13344 4101-4106 Protein denotes GATA3
T13345 4111-4116 Protein denotes FOXP3
T13346 4255-4259 Positive_regulation denotes high
T13347 4260-4265 Protein denotes GATA3
T13348 4266-4276 Gene_expression denotes expressing
T13349 4301-4308 Negative_regulation denotes absence
T13350 4312-4317 Protein denotes FOXP3
T13351 4343-4348 Protein denotes GATA3
T13352 4368-4377 Negative_regulation denotes inhibited
T13353 4378-4383 Protein denotes FOXP3
T13354 4384-4393 Positive_regulation denotes induction
T13355 4441-4451 Negative_regulation denotes inhibitory
T13356 4452-4458 Regulation denotes effect
T13357 4462-4467 Protein denotes GATA3
T13358 4517-4527 Gene_expression denotes expressing
T13359 4528-4533 Protein denotes GATA3
T13360 4554-4557 Protein denotes CD2
T13361 4558-4563 Protein denotes GATA3
T13362 4609-4623 Positive_regulation denotes overexpression
T13363 4627-4632 Protein denotes GATA3
T13364 4681-4687 Positive_regulation denotes induce
T13365 4688-4693 Protein denotes FOXP3
T13366 4694-4704 Gene_expression denotes expression
T13367 4751-4756 Protein denotes TGF-β
T13368 4782-4785 Protein denotes CD2
T13369 4786-4791 Protein denotes GATA3
T13370 4816-4821 Protein denotes FOXP3
T13371 4921-4926 Protein denotes GATA3
T13372 5161-5166 Protein denotes GATA3
T13373 5167-5181 Positive_regulation denotes overexpression
T13374 5237-5247 Negative_regulation denotes inhibiting
T13375 5260-5265 Protein denotes GATA3
T13376 5289-5294 Protein denotes GATA3
T13377 5368-5386 Protein denotes Repressor of GATA3
T13378 5388-5391 Protein denotes ROG
T13379 5431-5434 Protein denotes CD8
T13380 5582-5587 Protein denotes GATA3
T13381 5673-5678 Protein denotes GATA3
T13382 5679-5688 Negative_regulation denotes repressed
T13383 5689-5694 Protein denotes FOXP3
T13384 5695-5705 Gene_expression denotes expression
T13385 5718-5725 Binding denotes binding
T13386 5733-5738 Protein denotes FOXP3
T13387 5739-5747 Entity denotes promoter
T13388 5748-5754 Entity denotes region
T13389 5891-5896 Protein denotes FOXP3
T13390 6092-6099 Gene_expression denotes express
T13391 6100-6105 Protein denotes GATA3
T13392 6169-6176 Gene_expression denotes express
T13393 6177-6182 Protein denotes GATA3
T13394 6217-6222 Binding denotes bound
T13395 6226-6231 Protein denotes GATA3
T13396 6316-6321 Protein denotes GATA3
T13397 6322-6327 Binding denotes binds
T13398 6380-6385 Protein denotes GATA3
T13399 6390-6396 Positive_regulation denotes induce
T13400 6397-6410 Transcription denotes transcription
T13401 6589-6594 Protein denotes GATA3
T13402 6595-6605 Gene_expression denotes expression
T13403 6619-6627 Positive_regulation denotes required
T13404 6648-6653 Protein denotes FOXP3
T13405 6714-6719 Protein denotes GATA3
T13406 6723-6730 Negative_regulation denotes inhibit
T13407 6731-6736 Protein denotes FOXP3
T13408 6773-6781 Entity denotes -binding
T13409 6876-6881 Protein denotes GATA3
T13410 6886-6893 Negative_regulation denotes compete
T13411 6903-6910 Binding denotes binding
T13412 6914-6918 Protein denotes AP-1
T13413 6919-6923 Protein denotes NFAT
T13414 6931-6939 Entity denotes promoter
T13415 7001-7006 Protein denotes FOXP3
T13416 7021-7030 Regulation denotes regulated
T13417 7052-7056 Protein denotes IL-4
T13418 7058-7063 Protein denotes GATA3
T13419 7075-7084 Negative_regulation denotes inhibitor
T13420 7088-7093 Protein denotes FOXP3
T13421 7094-7104 Gene_expression denotes expression
T13422 7189-7196 Binding denotes binding
T13423 7201-7211 Negative_regulation denotes repressing
T13424 7216-7221 Protein denotes FOXP3
T13425 7222-7230 Entity denotes promoter
T13426 7277-7281 Protein denotes Il-4
T13427 7299-7308 Positive_regulation denotes induction
T13428 7312-7322 Negative_regulation denotes repressing
T13429 7323-7328 Protein denotes FOXP3
T13430 7329-7339 Gene_expression denotes expression
R9855 T13229 T13230 themeOf FOXP3,induction
R9856 T13230 T13231 themeOf induction,inhibited
R9857 T13232 T13231 causeOf GATA3,inhibited
R9858 T13234 T13236 causeOf CD4,up-regulate
R9859 T13235 T13236 causeOf CD25,up-regulate
R9860 T13237 T13236 themeOf FOXP3,up-regulate
R9861 T13238 T13239 themeOf FOXP3,induction
R9862 T13241 T13240 themeOf FOXP3,up-regulate
R9863 T13242 T13240 causeOf TGF-β,up-regulate
R9864 T13249 T13248 themeOf induction,mandatory
R9865 T13250 T13249 themeOf FOXP3,induction
R9866 T13252 T13251 themeOf GATA3,expression
R9867 T13253 T13251 themeOf T-bet,expression
R9868 T13257 T13258 themeOf FOXP3,expression
R9869 T13259 T13260 themeOf FOXP3,expressing
R9870 T13261 T13263 themeOf GATA3,up-regulated
R9871 T13262 T13263 themeOf T-bet,up-regulated
R9872 T13264 T13265 themeOf FOXP3,promoting
R9873 T13266 T13265 causeOf CTLA-4,promoting
R9874 T13268 T13269 themeOf GATA3,expression
R9875 T13269 T13267 themeOf expression,inhibitors
R9876 T13270 T13271 causeOf GATA3,inhibits
R9877 T13272 T13273 themeOf FOXP3,expression
R9878 T13273 T13271 themeOf expression,inhibits
R9879 T13274 T13276 causeOf IL-4,inhibit
R9880 T13275 T13276 causeOf IL-13,inhibit
R9881 T13277 T13278 causeOf TGF-β,mediated
R9882 T13277 T13280 causeOf TGF-β,induction
R9883 T13279 T13280 themeOf FOXP3,induction
R9884 T13280 T13276 themeOf induction,inhibit
R9885 T13280 T13278 themeOf induction,mediated
R9886 T13289 T13292 causeOf express,inhibit
R9887 T13290 T13289 themeOf CD25,express
R9888 T13291 T13292 causeOf IL-4,inhibit
R9889 T13293 T13294 themeOf Foxp3,expression
R9890 T13294 T13292 themeOf expression,inhibit
R9891 T13297 T13298 themeOf Foxp3,expression
R9892 T13298 T13296 themeOf expression,drop
R9893 T13300 T13301 themeOf IL-17,producing
R9894 T13312 T13313 causeOf IL-4,enhanced
R9895 T13314 T13315 themeOf FOXP3,expression
R9896 T13315 T13313 themeOf expression,enhanced
R9897 T13317 T13318 themeOf GATA3,expression
R9898 T13318 T13316 themeOf expression,induce
R9899 T13319 T13320 causeOf IL-4,regulate
R9900 T13321 T13322 themeOf FOXP3,expression
R9901 T13322 T13320 themeOf expression,regulate
R9902 T13323 T13324 causeOf IL-13,reduce
R9903 T13323 T13326 causeOf IL-13,induce
R9904 T13325 T13324 themeOf FOXP3,reduce
R9905 T13327 T13326 themeOf GATA3,induce
R9906 T13328 T13330 causeOf IL-4,inhibition
R9907 T13328 T13329 causeOf IL-4,dependent
R9908 T13329 T13332 themeOf dependent,mediated
R9909 T13330 T13332 themeOf inhibition,mediated
R9910 T13331 T13330 themeOf FOXP3,inhibition
R9911 T13333 T13332 causeOf GATA3,mediated
R9912 T13334 T13337 causeOf GATA3,repressed
R9913 T13334 T13335 causeOf GATA3,inducing
R9914 T13336 T13335 themeOf IL-4,inducing
R9915 T13339 T13337 themeOf mediated,repressed
R9916 T13340 T13341 themeOf FOXP3,expression
R9917 T13341 T13339 themeOf expression,mediated
R9918 T13347 T13348 themeOf GATA3,expressing
R9919 T13348 T13346 themeOf expressing,high
R9920 T13350 T13349 themeOf FOXP3,absence
R9921 T13353 T13354 themeOf FOXP3,induction
R9922 T13354 T13352 themeOf induction,inhibited
R9923 T13359 T13358 themeOf GATA3,expressing
R9924 T13363 T13362 themeOf GATA3,overexpression
R9925 T13365 T13366 themeOf FOXP3,expression
R9926 T13366 T13364 themeOf expression,induce
R9927 T13372 T13373 themeOf GATA3,overexpression
R9928 T13375 T13374 themeOf GATA3,inhibiting
R9929 T13378 T13377 equivalentTo ROG,Repressor of GATA3
R9930 T13381 T13382 causeOf GATA3,repressed
R9931 T13381 T13385 themeOf GATA3,binding
R9932 T13383 T13384 themeOf FOXP3,expression
R9933 T13384 T13382 themeOf expression,repressed
R9934 T13385 T13382 causeOf binding,repressed
R9935 T13391 T13390 themeOf GATA3,express
R9936 T13393 T13392 themeOf GATA3,express
R9937 T13395 T13394 themeOf GATA3,bound
R9938 T13396 T13397 themeOf GATA3,binds
R9939 T13400 T13399 themeOf transcription,induce
R9940 T13401 T13402 themeOf GATA3,expression
R9941 T13402 T13403 causeOf expression,required
R9942 T13405 T13406 causeOf GATA3,inhibit
R9943 T13407 T13406 themeOf FOXP3,inhibit
R9944 T13409 T13410 causeOf GATA3,compete
R9945 T13411 T13410 themeOf binding,compete
R9946 T13412 T13411 themeOf AP-1,binding
R9947 T13413 T13411 themeOf NFAT,binding
R9948 T13414 T13407 partOf promoter,FOXP3
R9949 T13414 T13411 themeOf promoter,binding
R9950 T13417 T13416 causeOf IL-4,regulated
R9951 T13418 T13422 themeOf GATA3,binding
R9952 T13418 T13423 causeOf GATA3,repressing
R9953 T13420 T13421 themeOf FOXP3,expression
R9954 T13421 T13419 themeOf expression,inhibitor
R9955 T13425 T13424 partOf promoter,FOXP3
R9956 T13425 T13423 themeOf promoter,repressing
R9957 T13429 T13430 themeOf FOXP3,expression
R9958 T13430 T13428 themeOf expression,repressing