PMC:2222968 / 159-1494
Annnotations
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T121 | 0-13 | NN | denotes | Transcription |
T122 | 14-21 | NN | denotes | factors |
T123 | 22-25 | VB | denotes | act |
T124 | 26-28 | IN | denotes | in |
T125 | 29-36 | NN | denotes | concert |
T126 | 37-39 | TO | denotes | to |
T127 | 40-46 | VB | denotes | induce |
T128 | 47-54 | NN | denotes | lineage |
T129 | 55-65 | NN | denotes | commitment |
T130 | 66-73 | IN | denotes | towards |
T131 | 74-77 | NN | denotes | Th1 |
T132 | 77-78 | -COMMA- | denotes | , |
T133 | 79-82 | NN | denotes | Th2 |
T134 | 82-83 | -COMMA- | denotes | , |
T135 | 84-86 | CC | denotes | or |
T136 | 87-88 | NN | denotes | T |
T137 | 89-99 | JJ | denotes | regulatory |
T138 | 100-101 | -LRB- | denotes | ( |
T139 | 101-105 | NN | denotes | Treg |
T140 | 105-106 | -RRB- | denotes | ) |
T141 | 107-112 | NN | denotes | cells |
T142 | 112-113 | -COMMA- | denotes | , |
T143 | 114-117 | CC | denotes | and |
T144 | 118-123 | PRP-DOLLAR- | denotes | their |
T145 | 124-142 | JJ | denotes | counter-regulatory |
T146 | 143-153 | NN | denotes | mechanisms |
T147 | 154-158 | VB | denotes | were |
T148 | 159-164 | VB | denotes | shown |
T149 | 165-167 | TO | denotes | to |
T150 | 168-170 | VB | denotes | be |
T151 | 171-179 | JJ | denotes | critical |
T152 | 180-183 | IN | denotes | for |
T153 | 184-196 | NN | denotes | polarization |
T154 | 197-204 | IN | denotes | between |
T155 | 205-208 | NN | denotes | Th1 |
T156 | 209-212 | CC | denotes | and |
T157 | 213-216 | NN | denotes | Th2 |
T158 | 217-227 | NN | denotes | phenotypes |
T159 | 229-234 | NN | denotes | FOXP3 |
T160 | 235-237 | VB | denotes | is |
T161 | 238-240 | DT | denotes | an |
T162 | 241-250 | JJ | denotes | essential |
T163 | 251-264 | NN | denotes | transcription |
T164 | 265-271 | NN | denotes | factor |
T165 | 272-275 | IN | denotes | for |
T166 | 276-283 | JJ | denotes | natural |
T167 | 283-284 | -COMMA- | denotes | , |
T168 | 285-299 | JJ | denotes | thymus-derived |
T169 | 300-301 | -LRB- | denotes | ( |
T170 | 301-306 | NN | denotes | nTreg |
T171 | 306-307 | -RRB- | denotes | ) |
T172 | 308-311 | CC | denotes | and |
T173 | 312-321 | JJ | denotes | inducible |
T174 | 322-326 | NN | denotes | Treg |
T175 | 327-328 | -LRB- | denotes | ( |
T176 | 328-333 | NN | denotes | iTreg |
T177 | 333-334 | -RRB- | denotes | ) |
T178 | 335-345 | NN | denotes | commitment |
T179 | 345-346 | -COLON- | denotes | ; |
T180 | 347-354 | RB | denotes | however |
T181 | 354-355 | -COMMA- | denotes | , |
T182 | 356-359 | DT | denotes | the |
T183 | 360-370 | NN | denotes | mechanisms |
T184 | 371-381 | VB | denotes | regulating |
T185 | 382-385 | PRP-DOLLAR- | denotes | its |
T186 | 386-396 | NN | denotes | expression |
T187 | 397-400 | VB | denotes | are |
T188 | 401-403 | RB | denotes | as |
T189 | 404-407 | RB | denotes | yet |
T190 | 408-415 | JJ | denotes | unknown |
T191 | 417-419 | PRP | denotes | We |
T192 | 420-428 | VB | denotes | describe |
T193 | 429-430 | DT | denotes | a |
T194 | 431-440 | NN | denotes | mechanism |
T195 | 441-452 | VB | denotes | controlling |
T196 | 453-458 | NN | denotes | iTreg |
T197 | 459-471 | NN | denotes | polarization |
T198 | 471-472 | -COMMA- | denotes | , |
T199 | 473-478 | WDT | denotes | which |
T200 | 479-481 | VB | denotes | is |
T201 | 482-491 | VB | denotes | overruled |
T202 | 492-494 | IN | denotes | by |
T203 | 495-498 | DT | denotes | the |
T204 | 499-502 | NN | denotes | Th2 |
T205 | 503-518 | NN | denotes | differentiation |
T206 | 519-526 | NN | denotes | pathway |
T207 | 528-530 | PRP | denotes | We |
T208 | 531-543 | VB | denotes | demonstrated |
T209 | 544-548 | IN | denotes | that |
T210 | 549-560 | NN | denotes | interleukin |
T211 | 561-562 | CD | denotes | 4 |
T212 | 563-564 | -LRB- | denotes | ( |
T213 | 564-568 | NN | denotes | IL-4 |
T214 | 568-569 | -RRB- | denotes | ) |
T215 | 570-577 | JJ | denotes | present |
T216 | 578-580 | IN | denotes | at |
T217 | 581-584 | DT | denotes | the |
T218 | 585-589 | NN | denotes | time |
T219 | 590-592 | IN | denotes | of |
T220 | 593-594 | NN | denotes | T |
T221 | 595-599 | NN | denotes | cell |
T222 | 600-607 | NN | denotes | priming |
T223 | 608-616 | VB | denotes | inhibits |
T224 | 617-622 | NN | denotes | FOXP3 |
T225 | 624-628 | DT | denotes | This |
T226 | 629-639 | JJ | denotes | inhibitory |
T227 | 640-649 | NN | denotes | mechanism |
T228 | 650-653 | VB | denotes | was |
T229 | 654-658 | RB | denotes | also |
T230 | 659-668 | VB | denotes | confirmed |
T231 | 669-671 | IN | denotes | in |
T232 | 672-675 | NN | denotes | Th2 |
T233 | 676-681 | NN | denotes | cells |
T234 | 682-685 | CC | denotes | and |
T235 | 686-688 | IN | denotes | in |
T236 | 689-690 | NN | denotes | T |
T237 | 691-696 | NN | denotes | cells |
T238 | 697-699 | IN | denotes | of |
T239 | 700-710 | JJ | denotes | transgenic |
T240 | 711-715 | NN | denotes | mice |
T241 | 716-730 | VB | denotes | overexpressing |
T242 | 731-737 | NN | denotes | GATA-3 |
T243 | 738-740 | IN | denotes | in |
T244 | 741-742 | NN | denotes | T |
T245 | 743-748 | NN | denotes | cells |
T246 | 748-749 | -COMMA- | denotes | , |
T247 | 750-755 | WDT | denotes | which |
T248 | 756-759 | VB | denotes | are |
T249 | 760-765 | VB | denotes | shown |
T250 | 766-768 | TO | denotes | to |
T251 | 769-771 | VB | denotes | be |
T252 | 772-781 | JJ | denotes | deficient |
T253 | 782-784 | IN | denotes | in |
T254 | 785-797 | VB | denotes | transforming |
T255 | 798-804 | NN | denotes | growth |
T256 | 805-811 | NN | denotes | factor |
T257 | 812-813 | -LRB- | denotes | ( |
T258 | 813-816 | NN | denotes | TGF |
T259 | 816-817 | -RRB- | denotes | ) |
T260 | 817-828 | JJ | denotes | -β–mediated |
T261 | 829-834 | NN | denotes | FOXP3 |
T262 | 835-844 | NN | denotes | induction |
T263 | 846-850 | DT | denotes | This |
T264 | 851-861 | NN | denotes | inhibition |
T265 | 862-864 | VB | denotes | is |
T266 | 865-873 | VB | denotes | mediated |
T267 | 874-876 | IN | denotes | by |
T268 | 877-883 | JJ | denotes | direct |
T269 | 884-891 | NN | denotes | binding |
T270 | 892-894 | IN | denotes | of |
T271 | 895-900 | NN | denotes | GATA3 |
T272 | 901-903 | TO | denotes | to |
T273 | 904-907 | DT | denotes | the |
T274 | 908-913 | NN | denotes | FOXP3 |
T275 | 914-922 | NN | denotes | promoter |
T276 | 922-923 | -COMMA- | denotes | , |
T277 | 924-929 | WDT | denotes | which |
T278 | 930-939 | VB | denotes | represses |
T279 | 940-943 | PRP-DOLLAR- | denotes | its |
T280 | 944-959 | NN | denotes | transactivation |
T281 | 960-967 | NN | denotes | process |
T282 | 969-978 | RB | denotes | Therefore |
T283 | 978-979 | -COMMA- | denotes | , |
T284 | 980-984 | DT | denotes | this |
T285 | 985-990 | NN | denotes | study |
T286 | 991-999 | VB | denotes | provides |
T287 | 1000-1001 | DT | denotes | a |
T288 | 1002-1005 | JJ | denotes | new |
T289 | 1006-1019 | NN | denotes | understanding |
T290 | 1020-1022 | IN | denotes | of |
T291 | 1023-1032 | NN | denotes | tolerance |
T292 | 1033-1044 | NN | denotes | development |
T293 | 1044-1045 | -COMMA- | denotes | , |
T294 | 1046-1056 | VB | denotes | controlled |
T295 | 1057-1059 | IN | denotes | by |
T296 | 1060-1061 | DT | denotes | a |
T297 | 1062-1066 | NN | denotes | type |
T298 | 1067-1068 | CD | denotes | 2 |
T299 | 1069-1075 | JJ | denotes | immune |
T300 | 1076-1084 | NN | denotes | response |
T301 | 1086-1090 | NN | denotes | IL-4 |
T302 | 1091-1100 | NN | denotes | treatment |
T303 | 1101-1103 | IN | denotes | in |
T304 | 1104-1108 | NN | denotes | mice |
T305 | 1109-1116 | VB | denotes | reduces |
T306 | 1117-1122 | NN | denotes | iTreg |
T307 | 1123-1127 | NN | denotes | cell |
T308 | 1128-1137 | NN | denotes | frequency |
T309 | 1137-1138 | -COMMA- | denotes | , |
T310 | 1139-1151 | VB | denotes | highlighting |
T311 | 1152-1156 | IN | denotes | that |
T312 | 1157-1168 | JJ | denotes | therapeutic |
T313 | 1169-1179 | NN | denotes | approaches |
T314 | 1180-1184 | WDT | denotes | that |
T315 | 1185-1191 | VB | denotes | target |
T316 | 1192-1196 | NN | denotes | IL-4 |
T317 | 1197-1199 | CC | denotes | or |
T318 | 1200-1205 | NN | denotes | GATA3 |
T319 | 1206-1211 | MD | denotes | might |
T320 | 1212-1219 | VB | denotes | provide |
T321 | 1220-1223 | JJ | denotes | new |
T322 | 1224-1234 | JJ | denotes | preventive |
T323 | 1235-1245 | NN | denotes | strategies |
T324 | 1246-1258 | VB | denotes | facilitating |
T325 | 1259-1268 | NN | denotes | tolerance |
T326 | 1269-1278 | NN | denotes | induction |
T327 | 1279-1291 | RB | denotes | particularly |
T328 | 1292-1294 | IN | denotes | in |
T329 | 1295-1307 | JJ | denotes | Th2-mediated |
T330 | 1308-1316 | NN | denotes | diseases |
T331 | 1316-1317 | -COMMA- | denotes | , |
T332 | 1318-1322 | JJ | denotes | such |
T333 | 1323-1325 | IN | denotes | as |
T334 | 1326-1333 | NN | denotes | allergy |
R57 | T122 | T121 | arg1Of | factors,Transcription |
R58 | T122 | T123 | arg1Of | factors,act |
R59 | T122 | T127 | arg1Of | factors,induce |
R60 | T123 | T124 | arg1Of | act,in |
R61 | T123 | T126 | modOf | act,to |
R62 | T123 | T143 | arg1Of | act,and |
R63 | T125 | T124 | arg2Of | concert,in |
R64 | T127 | T126 | arg1Of | induce,to |
R65 | T129 | T127 | arg2Of | commitment,induce |
R66 | T129 | T128 | arg1Of | commitment,lineage |
R67 | T129 | T130 | arg1Of | commitment,towards |
R68 | T131 | T132 | arg1Of | Th1,"," |
R69 | T132 | T135 | arg1Of | ",",or |
R70 | T133 | T132 | arg2Of | Th2,"," |
R71 | T135 | T134 | arg1Of | or,"," |
R72 | T136 | T135 | arg2Of | T,or |
R73 | T139 | T138 | arg2Of | Treg,( |
R74 | T140 | T138 | arg3Of | ),( |
R75 | T141 | T130 | arg2Of | cells,towards |
R76 | T141 | T131 | arg1Of | cells,Th1 |
R77 | T141 | T133 | arg1Of | cells,Th2 |
R78 | T141 | T136 | arg1Of | cells,T |
R79 | T141 | T137 | arg1Of | cells,regulatory |
R80 | T141 | T138 | arg1Of | cells,( |
R81 | T143 | T142 | arg1Of | and,"," |
R82 | T146 | T144 | arg1Of | mechanisms,their |
R83 | T146 | T145 | arg1Of | mechanisms,counter-regulatory |
R84 | T146 | T147 | arg1Of | mechanisms,were |
R85 | T146 | T148 | arg2Of | mechanisms,shown |
R86 | T146 | T150 | arg1Of | mechanisms,be |
R87 | T146 | T151 | arg1Of | mechanisms,critical |
R88 | T148 | T143 | arg2Of | shown,and |
R89 | T148 | T147 | arg2Of | shown,were |
R90 | T150 | T148 | arg3Of | be,shown |
R91 | T150 | T149 | arg1Of | be,to |
R92 | T151 | T150 | arg2Of | critical,be |
R93 | T151 | T152 | arg1Of | critical,for |
R94 | T153 | T152 | arg2Of | polarization,for |
R95 | T153 | T154 | arg1Of | polarization,between |
R96 | T155 | T156 | arg1Of | Th1,and |
R97 | T157 | T156 | arg2Of | Th2,and |
R98 | T158 | T154 | arg2Of | phenotypes,between |
R99 | T158 | T155 | arg1Of | phenotypes,Th1 |
R100 | T158 | T157 | arg1Of | phenotypes,Th2 |
R101 | T159 | T160 | arg1Of | FOXP3,is |
R102 | T160 | T179 | arg1Of | is,; |
R103 | T164 | T160 | arg2Of | factor,is |
R104 | T164 | T161 | arg1Of | factor,an |
R105 | T164 | T162 | arg1Of | factor,essential |
R106 | T164 | T163 | arg1Of | factor,transcription |
R107 | T164 | T165 | arg1Of | factor,for |
R108 | T166 | T167 | arg1Of | natural,"," |
R109 | T168 | T167 | arg2Of | thymus-derived,"," |
R110 | T170 | T166 | arg1Of | nTreg,natural |
R111 | T170 | T168 | arg1Of | nTreg,thymus-derived |
R112 | T170 | T169 | arg2Of | nTreg,( |
R113 | T170 | T172 | arg1Of | nTreg,and |
R114 | T171 | T169 | arg3Of | ),( |
R115 | T172 | T165 | arg2Of | and,for |
R116 | T176 | T175 | arg2Of | iTreg,( |
R117 | T177 | T175 | arg3Of | ),( |
R118 | T178 | T172 | arg2Of | commitment,and |
R119 | T178 | T173 | arg1Of | commitment,inducible |
R120 | T178 | T174 | arg1Of | commitment,Treg |
R121 | T178 | T175 | arg1Of | commitment,( |
R122 | T183 | T182 | arg1Of | mechanisms,the |
R123 | T183 | T184 | arg1Of | mechanisms,regulating |
R124 | T183 | T187 | arg1Of | mechanisms,are |
R125 | T183 | T190 | arg1Of | mechanisms,unknown |
R126 | T186 | T184 | arg2Of | expression,regulating |
R127 | T186 | T185 | arg1Of | expression,its |
R128 | T187 | T179 | arg2Of | are,; |
R129 | T187 | T180 | arg1Of | are,however |
R130 | T187 | T181 | arg1Of | are,"," |
R131 | T187 | T189 | arg1Of | are,yet |
R132 | T189 | T188 | arg1Of | yet,as |
R133 | T190 | T187 | arg2Of | unknown,are |
R134 | T191 | T192 | arg1Of | We,describe |
R135 | T194 | T192 | arg2Of | mechanism,describe |
R136 | T194 | T193 | arg1Of | mechanism,a |
R137 | T194 | T195 | arg1Of | mechanism,controlling |
R138 | T197 | T195 | arg2Of | polarization,controlling |
R139 | T197 | T196 | arg1Of | polarization,iTreg |
R140 | T197 | T198 | arg1Of | polarization,"," |
R141 | T197 | T199 | arg1Of | polarization,which |
R142 | T197 | T200 | arg1Of | polarization,is |
R143 | T197 | T201 | arg2Of | polarization,overruled |
R144 | T201 | T200 | arg2Of | overruled,is |
R145 | T206 | T201 | arg1Of | pathway,overruled |
R146 | T206 | T202 | arg2Of | pathway,by |
R147 | T206 | T203 | arg1Of | pathway,the |
R148 | T206 | T204 | arg1Of | pathway,Th2 |
R149 | T206 | T205 | arg1Of | pathway,differentiation |
R150 | T207 | T208 | arg1Of | We,demonstrated |
R151 | T210 | T211 | arg1Of | interleukin,4 |
R152 | T210 | T212 | arg1Of | interleukin,( |
R153 | T210 | T215 | arg1Of | interleukin,present |
R154 | T210 | T223 | arg1Of | interleukin,inhibits |
R155 | T213 | T212 | arg2Of | IL-4,( |
R156 | T214 | T212 | arg3Of | ),( |
R157 | T215 | T216 | arg1Of | present,at |
R158 | T218 | T216 | arg2Of | time,at |
R159 | T218 | T217 | arg1Of | time,the |
R160 | T218 | T219 | arg1Of | time,of |
R161 | T222 | T219 | arg2Of | priming,of |
R162 | T222 | T220 | arg1Of | priming,T |
R163 | T222 | T221 | arg1Of | priming,cell |
R164 | T223 | T208 | arg2Of | inhibits,demonstrated |
R165 | T223 | T209 | arg1Of | inhibits,that |
R166 | T224 | T223 | arg2Of | FOXP3,inhibits |
R167 | T227 | T225 | arg1Of | mechanism,This |
R168 | T227 | T226 | arg1Of | mechanism,inhibitory |
R169 | T227 | T228 | arg1Of | mechanism,was |
R170 | T227 | T230 | arg2Of | mechanism,confirmed |
R171 | T230 | T228 | arg2Of | confirmed,was |
R172 | T230 | T229 | arg1Of | confirmed,also |
R173 | T230 | T231 | arg1Of | confirmed,in |
R174 | T230 | T235 | arg1Of | confirmed,in |
R175 | T231 | T234 | arg1Of | in,and |
R176 | T233 | T231 | arg2Of | cells,in |
R177 | T233 | T232 | arg1Of | cells,Th2 |
R178 | T235 | T234 | arg2Of | in,and |
R179 | T237 | T235 | arg2Of | cells,in |
R180 | T237 | T236 | arg1Of | cells,T |
R181 | T237 | T238 | arg1Of | cells,of |
R182 | T240 | T238 | arg2Of | mice,of |
R183 | T240 | T239 | arg1Of | mice,transgenic |
R184 | T240 | T241 | arg1Of | mice,overexpressing |
R185 | T240 | T246 | arg1Of | mice,"," |
R186 | T240 | T247 | arg1Of | mice,which |
R187 | T240 | T248 | arg1Of | mice,are |
R188 | T240 | T249 | arg2Of | mice,shown |
R189 | T240 | T251 | arg1Of | mice,be |
R190 | T240 | T252 | arg1Of | mice,deficient |
R191 | T241 | T243 | arg1Of | overexpressing,in |
R192 | T242 | T241 | arg2Of | GATA-3,overexpressing |
R193 | T245 | T243 | arg2Of | cells,in |
R194 | T245 | T244 | arg1Of | cells,T |
R195 | T249 | T248 | arg2Of | shown,are |
R196 | T251 | T249 | arg3Of | be,shown |
R197 | T251 | T250 | arg1Of | be,to |
R198 | T252 | T251 | arg2Of | deficient,be |
R199 | T252 | T253 | arg1Of | deficient,in |
R200 | T254 | T253 | arg2Of | transforming,in |
R201 | T258 | T257 | arg2Of | TGF,( |
R202 | T259 | T257 | arg3Of | ),( |
R203 | T262 | T254 | arg2Of | induction,transforming |
R204 | T262 | T255 | arg1Of | induction,growth |
R205 | T262 | T256 | arg1Of | induction,factor |
R206 | T262 | T257 | arg1Of | induction,( |
R207 | T262 | T260 | arg1Of | induction,-β–mediated |
R208 | T262 | T261 | arg1Of | induction,FOXP3 |
R209 | T264 | T263 | arg1Of | inhibition,This |
R210 | T264 | T265 | arg1Of | inhibition,is |
R211 | T264 | T266 | arg2Of | inhibition,mediated |
R212 | T266 | T265 | arg2Of | mediated,is |
R213 | T269 | T266 | arg1Of | binding,mediated |
R214 | T269 | T267 | arg2Of | binding,by |
R215 | T269 | T268 | arg1Of | binding,direct |
R216 | T269 | T270 | arg1Of | binding,of |
R217 | T269 | T272 | arg1Of | binding,to |
R218 | T269 | T276 | arg1Of | binding,"," |
R219 | T269 | T277 | arg1Of | binding,which |
R220 | T269 | T278 | arg1Of | binding,represses |
R221 | T271 | T270 | arg2Of | GATA3,of |
R222 | T275 | T272 | arg2Of | promoter,to |
R223 | T275 | T273 | arg1Of | promoter,the |
R224 | T275 | T274 | arg1Of | promoter,FOXP3 |
R225 | T281 | T278 | arg2Of | process,represses |
R226 | T281 | T279 | arg1Of | process,its |
R227 | T281 | T280 | arg1Of | process,transactivation |
R228 | T285 | T284 | arg1Of | study,this |
R229 | T285 | T286 | arg1Of | study,provides |
R230 | T286 | T282 | arg1Of | provides,Therefore |
R231 | T286 | T283 | arg1Of | provides,"," |
R232 | T289 | T286 | arg2Of | understanding,provides |
R233 | T289 | T287 | arg1Of | understanding,a |
R234 | T289 | T288 | arg1Of | understanding,new |
R235 | T289 | T290 | arg1Of | understanding,of |
R236 | T289 | T293 | arg1Of | understanding,"," |
R237 | T289 | T294 | arg2Of | understanding,controlled |
R238 | T292 | T290 | arg2Of | development,of |
R239 | T292 | T291 | arg1Of | development,tolerance |
R240 | T300 | T294 | arg1Of | response,controlled |
R241 | T300 | T295 | arg2Of | response,by |
R242 | T300 | T296 | arg1Of | response,a |
R243 | T300 | T297 | arg1Of | response,type |
R244 | T300 | T298 | arg1Of | response,2 |
R245 | T300 | T299 | arg1Of | response,immune |
R246 | T302 | T301 | arg1Of | treatment,IL-4 |
R247 | T302 | T303 | arg1Of | treatment,in |
R248 | T302 | T305 | arg1Of | treatment,reduces |
R249 | T302 | T310 | arg1Of | treatment,highlighting |
R250 | T304 | T303 | arg2Of | mice,in |
R251 | T305 | T309 | arg1Of | reduces,"," |
R252 | T305 | T310 | modOf | reduces,highlighting |
R253 | T308 | T305 | arg2Of | frequency,reduces |
R254 | T308 | T306 | arg1Of | frequency,iTreg |
R255 | T308 | T307 | arg1Of | frequency,cell |
R256 | T313 | T312 | arg1Of | approaches,therapeutic |
R257 | T313 | T314 | arg1Of | approaches,that |
R258 | T313 | T315 | arg1Of | approaches,target |
R259 | T313 | T319 | arg1Of | approaches,might |
R260 | T313 | T320 | arg1Of | approaches,provide |
R261 | T316 | T317 | arg1Of | IL-4,or |
R262 | T317 | T315 | arg2Of | or,target |
R263 | T318 | T317 | arg2Of | GATA3,or |
R264 | T320 | T310 | arg2Of | provide,highlighting |
R265 | T320 | T311 | arg1Of | provide,that |
R266 | T320 | T319 | arg2Of | provide,might |
R267 | T320 | T328 | arg1Of | provide,in |
R268 | T323 | T320 | arg2Of | strategies,provide |
R269 | T323 | T321 | arg1Of | strategies,new |
R270 | T323 | T322 | arg1Of | strategies,preventive |
R271 | T323 | T324 | arg1Of | strategies,facilitating |
R272 | T326 | T324 | arg2Of | induction,facilitating |
R273 | T326 | T325 | arg1Of | induction,tolerance |
R274 | T328 | T327 | arg1Of | in,particularly |
R275 | T330 | T328 | arg2Of | diseases,in |
R276 | T330 | T329 | arg1Of | diseases,Th2-mediated |
R277 | T330 | T331 | arg1Of | diseases,"," |
R278 | T330 | T333 | arg1Of | diseases,as |
R279 | T333 | T332 | arg1Of | as,such |
R280 | T334 | T333 | arg2Of | allergy,as |
bionlp-st-ge-2016-coref
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T335 | 382-385 | Anaphor | denotes | its |
T336 | 229-234 | Antecedent | denotes | FOXP3 |
T337 | 846-861 | Anaphor | denotes | This inhibition |
T338 | 772-781 | Antecedent | denotes | deficient |
R634 | T335 | T336 | boundBy | its,FOXP3 |
R635 | T337 | T338 | boundBy | This inhibition,deficient |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T376 | 0-13 | NNP | denotes | Transcription |
T377 | 14-21 | NNS | denotes | factors |
T378 | 22-25 | VBP | denotes | act |
T379 | 26-28 | IN | denotes | in |
T380 | 29-36 | NN | denotes | concert |
T381 | 37-39 | TO | denotes | to |
T382 | 40-46 | VB | denotes | induce |
T383 | 47-54 | NN | denotes | lineage |
T384 | 55-65 | NN | denotes | commitment |
T385 | 66-73 | IN | denotes | towards |
T386 | 74-77 | NNP | denotes | Th1 |
T387 | 77-78 | , | denotes | , |
T388 | 79-82 | NNP | denotes | Th2 |
T389 | 82-83 | , | denotes | , |
T390 | 84-86 | CC | denotes | or |
T391 | 87-88 | NNP | denotes | T |
T392 | 89-99 | JJ | denotes | regulatory |
T393 | 100-101 | -LRB- | denotes | ( |
T394 | 101-105 | NNP | denotes | Treg |
T395 | 105-106 | -RRB- | denotes | ) |
T396 | 107-112 | NNS | denotes | cells |
T397 | 112-113 | , | denotes | , |
T398 | 114-117 | CC | denotes | and |
T399 | 118-123 | PRP$ | denotes | their |
T400 | 124-142 | JJ | denotes | counter-regulatory |
T401 | 143-153 | NNS | denotes | mechanisms |
T402 | 154-158 | VBD | denotes | were |
T403 | 159-164 | VBN | denotes | shown |
T404 | 165-167 | TO | denotes | to |
T405 | 168-170 | VB | denotes | be |
T406 | 171-179 | JJ | denotes | critical |
T407 | 180-183 | IN | denotes | for |
T408 | 184-196 | NN | denotes | polarization |
T409 | 197-204 | IN | denotes | between |
T410 | 205-208 | CD | denotes | Th1 |
T411 | 209-212 | CC | denotes | and |
T412 | 213-216 | CD | denotes | Th2 |
T413 | 217-227 | NNS | denotes | phenotypes |
T414 | 227-228 | . | denotes | . |
T415 | 229-234 | CD | denotes | FOXP3 |
T416 | 235-237 | VBZ | denotes | is |
T417 | 238-240 | DT | denotes | an |
T418 | 241-250 | JJ | denotes | essential |
T419 | 251-264 | NN | denotes | transcription |
T420 | 265-271 | NN | denotes | factor |
T421 | 272-275 | IN | denotes | for |
T422 | 276-283 | JJ | denotes | natural |
T423 | 283-284 | , | denotes | , |
T424 | 285-299 | JJ | denotes | thymus-derived |
T425 | 300-301 | -LRB- | denotes | ( |
T426 | 301-306 | NNP | denotes | nTreg |
T427 | 306-307 | -RRB- | denotes | ) |
T428 | 308-311 | CC | denotes | and |
T429 | 312-321 | JJ | denotes | inducible |
T430 | 322-326 | NNP | denotes | Treg |
T431 | 327-328 | -LRB- | denotes | ( |
T432 | 328-333 | NNP | denotes | iTreg |
T433 | 333-334 | -RRB- | denotes | ) |
T434 | 335-345 | NN | denotes | commitment |
T435 | 345-346 | : | denotes | ; |
T436 | 347-354 | RB | denotes | however |
T437 | 354-355 | , | denotes | , |
T438 | 356-359 | DT | denotes | the |
T439 | 360-370 | NNS | denotes | mechanisms |
T440 | 371-381 | VBG | denotes | regulating |
T441 | 382-385 | PRP$ | denotes | its |
T442 | 386-396 | NN | denotes | expression |
T443 | 397-400 | VBP | denotes | are |
T444 | 401-403 | RB | denotes | as |
T445 | 404-407 | RB | denotes | yet |
T446 | 408-415 | JJ | denotes | unknown |
T447 | 415-416 | . | denotes | . |
T448 | 417-419 | PRP | denotes | We |
T449 | 420-428 | VBP | denotes | describe |
T450 | 429-430 | DT | denotes | a |
T451 | 431-440 | NN | denotes | mechanism |
T452 | 441-452 | VBG | denotes | controlling |
T453 | 453-458 | NNP | denotes | iTreg |
T454 | 459-471 | NN | denotes | polarization |
T455 | 471-472 | , | denotes | , |
T456 | 473-478 | WDT | denotes | which |
T457 | 479-481 | VBZ | denotes | is |
T458 | 482-491 | VBN | denotes | overruled |
T459 | 492-494 | IN | denotes | by |
T460 | 495-498 | DT | denotes | the |
T461 | 499-502 | JJ | denotes | Th2 |
T462 | 503-518 | NN | denotes | differentiation |
T463 | 519-526 | NN | denotes | pathway |
T464 | 526-527 | . | denotes | . |
T465 | 528-530 | PRP | denotes | We |
T466 | 531-543 | VBD | denotes | demonstrated |
T467 | 544-548 | IN | denotes | that |
T468 | 549-560 | NN | denotes | interleukin |
T469 | 561-562 | CD | denotes | 4 |
T470 | 563-564 | -LRB- | denotes | ( |
T471 | 564-568 | NN | denotes | IL-4 |
T472 | 568-569 | -RRB- | denotes | ) |
T473 | 570-577 | NN | denotes | present |
T474 | 578-580 | IN | denotes | at |
T475 | 581-584 | DT | denotes | the |
T476 | 585-589 | NN | denotes | time |
T477 | 590-592 | IN | denotes | of |
T478 | 593-594 | NNP | denotes | T |
T479 | 595-599 | NN | denotes | cell |
T480 | 600-607 | VBG | denotes | priming |
T481 | 608-616 | NNS | denotes | inhibits |
T482 | 617-622 | NNP | denotes | FOXP3 |
T483 | 622-623 | . | denotes | . |
T484 | 624-628 | DT | denotes | This |
T485 | 629-639 | JJ | denotes | inhibitory |
T486 | 640-649 | NN | denotes | mechanism |
T487 | 650-653 | VBD | denotes | was |
T488 | 654-658 | RB | denotes | also |
T489 | 659-668 | VBN | denotes | confirmed |
T490 | 669-671 | IN | denotes | in |
T491 | 672-675 | JJ | denotes | Th2 |
T492 | 676-681 | NNS | denotes | cells |
T493 | 682-685 | CC | denotes | and |
T494 | 686-688 | IN | denotes | in |
T495 | 689-690 | NNP | denotes | T |
T496 | 691-696 | NNS | denotes | cells |
T497 | 697-699 | IN | denotes | of |
T498 | 700-710 | JJ | denotes | transgenic |
T499 | 711-715 | NNS | denotes | mice |
T500 | 716-730 | VBG | denotes | overexpressing |
T501 | 731-737 | NN | denotes | GATA-3 |
T502 | 738-740 | IN | denotes | in |
T503 | 741-742 | NNP | denotes | T |
T504 | 743-748 | NNS | denotes | cells |
T505 | 748-749 | , | denotes | , |
T506 | 750-755 | WDT | denotes | which |
T507 | 756-759 | VBP | denotes | are |
T508 | 760-765 | VBN | denotes | shown |
T509 | 766-768 | TO | denotes | to |
T510 | 769-771 | VB | denotes | be |
T511 | 772-781 | JJ | denotes | deficient |
T512 | 782-784 | IN | denotes | in |
T513 | 785-797 | VBG | denotes | transforming |
T514 | 798-804 | NN | denotes | growth |
T515 | 805-811 | NN | denotes | factor |
T516 | 812-813 | -LRB- | denotes | ( |
T517 | 813-816 | NNP | denotes | TGF |
T518 | 816-817 | -RRB- | denotes | ) |
T519 | 817-818 | : | denotes | - |
T520 | 818-819 | NN | denotes | β |
T521 | 820-828 | VBD | denotes | mediated |
T522 | 829-834 | CD | denotes | FOXP3 |
T523 | 835-844 | NN | denotes | induction |
T524 | 844-845 | . | denotes | . |
T525 | 846-850 | DT | denotes | This |
T526 | 851-861 | NN | denotes | inhibition |
T527 | 862-864 | VBZ | denotes | is |
T528 | 865-873 | VBN | denotes | mediated |
T529 | 874-876 | IN | denotes | by |
T530 | 877-883 | JJ | denotes | direct |
T531 | 884-891 | JJ | denotes | binding |
T532 | 892-894 | IN | denotes | of |
T533 | 895-900 | CD | denotes | GATA3 |
T534 | 901-903 | TO | denotes | to |
T535 | 904-907 | DT | denotes | the |
T536 | 908-913 | CD | denotes | FOXP3 |
T537 | 914-922 | NN | denotes | promoter |
T538 | 922-923 | , | denotes | , |
T539 | 924-929 | WDT | denotes | which |
T540 | 930-939 | VBZ | denotes | represses |
T541 | 940-943 | PRP$ | denotes | its |
T542 | 944-959 | NN | denotes | transactivation |
T543 | 960-967 | NN | denotes | process |
T544 | 967-968 | . | denotes | . |
T545 | 969-978 | RB | denotes | Therefore |
T546 | 978-979 | , | denotes | , |
T547 | 980-984 | DT | denotes | this |
T548 | 985-990 | NN | denotes | study |
T549 | 991-999 | VBZ | denotes | provides |
T550 | 1000-1001 | DT | denotes | a |
T551 | 1002-1005 | JJ | denotes | new |
T552 | 1006-1019 | NN | denotes | understanding |
T553 | 1020-1022 | IN | denotes | of |
T554 | 1023-1032 | NN | denotes | tolerance |
T555 | 1033-1044 | NN | denotes | development |
T556 | 1044-1045 | , | denotes | , |
T557 | 1046-1056 | VBN | denotes | controlled |
T558 | 1057-1059 | IN | denotes | by |
T559 | 1060-1061 | DT | denotes | a |
T560 | 1062-1066 | NN | denotes | type |
T561 | 1067-1068 | CD | denotes | 2 |
T562 | 1069-1075 | JJ | denotes | immune |
T563 | 1076-1084 | NN | denotes | response |
T564 | 1084-1085 | . | denotes | . |
T565 | 1086-1090 | NN | denotes | IL-4 |
T566 | 1091-1100 | NN | denotes | treatment |
T567 | 1101-1103 | IN | denotes | in |
T568 | 1104-1108 | NNS | denotes | mice |
T569 | 1109-1116 | VBZ | denotes | reduces |
T570 | 1117-1122 | NNP | denotes | iTreg |
T571 | 1123-1127 | NN | denotes | cell |
T572 | 1128-1137 | NN | denotes | frequency |
T573 | 1137-1138 | , | denotes | , |
T574 | 1139-1151 | VBG | denotes | highlighting |
T575 | 1152-1156 | IN | denotes | that |
T576 | 1157-1168 | JJ | denotes | therapeutic |
T577 | 1169-1179 | NNS | denotes | approaches |
T578 | 1180-1184 | WDT | denotes | that |
T579 | 1185-1191 | VBP | denotes | target |
T580 | 1192-1196 | NN | denotes | IL-4 |
T581 | 1197-1199 | CC | denotes | or |
T582 | 1200-1205 | NN | denotes | GATA3 |
T583 | 1206-1211 | MD | denotes | might |
T584 | 1212-1219 | VB | denotes | provide |
T585 | 1220-1223 | JJ | denotes | new |
T586 | 1224-1234 | JJ | denotes | preventive |
T587 | 1235-1245 | NNS | denotes | strategies |
T588 | 1246-1258 | VBG | denotes | facilitating |
T589 | 1259-1268 | NN | denotes | tolerance |
T590 | 1269-1278 | NN | denotes | induction |
T591 | 1279-1291 | RB | denotes | particularly |
T592 | 1292-1294 | IN | denotes | in |
T593 | 1295-1307 | JJ | denotes | Th2-mediated |
T594 | 1308-1316 | NNS | denotes | diseases |
T595 | 1316-1317 | , | denotes | , |
T596 | 1318-1322 | JJ | denotes | such |
T597 | 1323-1325 | IN | denotes | as |
T598 | 1326-1333 | NN | denotes | allergy |
T599 | 1333-1334 | . | denotes | . |
R296 | T376 | T377 | compound | Transcription,factors |
R299 | T379 | T378 | prep | in,act |
R300 | T380 | T379 | pobj | concert,in |
R301 | T381 | T382 | aux | to,induce |
R302 | T382 | T378 | advcl | induce,act |
R303 | T383 | T384 | compound | lineage,commitment |
R304 | T384 | T382 | dobj | commitment,induce |
R305 | T385 | T384 | prep | towards,commitment |
R306 | T386 | T385 | pobj | Th1,towards |
R307 | T387 | T386 | punct | ",",Th1 |
R308 | T388 | T386 | conj | Th2,Th1 |
R309 | T389 | T388 | punct | ",",Th2 |
R310 | T390 | T388 | cc | or,Th2 |
R311 | T391 | T388 | conj | T,Th2 |
R312 | T392 | T396 | amod | regulatory,cells |
R313 | T393 | T394 | punct | (,Treg |
R314 | T394 | T392 | appos | Treg,regulatory |
R315 | T395 | T394 | punct | ),Treg |
R316 | T396 | T385 | pobj | cells,towards |
R317 | T397 | T378 | punct | ",",act |
R318 | T398 | T378 | cc | and,act |
R319 | T399 | T401 | poss | their,mechanisms |
R320 | T400 | T401 | amod | counter-regulatory,mechanisms |
R321 | T401 | T403 | nsubjpass | mechanisms,shown |
R378 | T458 | T454 | relcl | overruled,polarization |
R379 | T459 | T458 | agent | by,overruled |
R380 | T460 | T463 | det | the,pathway |
R381 | T461 | T463 | amod | Th2,pathway |
R382 | T462 | T463 | compound | differentiation,pathway |
R383 | T463 | T459 | pobj | pathway,by |
R384 | T464 | T449 | punct | .,describe |
R385 | T465 | T466 | nsubj | We,demonstrated |
R386 | T466 | T466 | ROOT | demonstrated,demonstrated |
R387 | T467 | T481 | mark | that,inhibits |
R388 | T468 | T481 | nsubj | interleukin,inhibits |
R389 | T469 | T468 | nummod | 4,interleukin |
R390 | T470 | T471 | punct | (,IL-4 |
R391 | T471 | T468 | appos | IL-4,interleukin |
R392 | T472 | T471 | punct | ),IL-4 |
R393 | T473 | T468 | amod | present,interleukin |
R394 | T474 | T468 | prep | at,interleukin |
R395 | T475 | T476 | det | the,time |
R396 | T476 | T474 | pobj | time,at |
R397 | T477 | T476 | prep | of,time |
R398 | T478 | T479 | compound | T,cell |
R399 | T479 | T480 | compound | cell,priming |
R400 | T480 | T481 | nsubj | priming,inhibits |
R401 | T481 | T466 | ccomp | inhibits,demonstrated |
R402 | T482 | T481 | dobj | FOXP3,inhibits |
R403 | T483 | T466 | punct | .,demonstrated |
R404 | T484 | T486 | det | This,mechanism |
R405 | T485 | T486 | amod | inhibitory,mechanism |
R406 | T486 | T489 | nsubjpass | mechanism,confirmed |
R407 | T487 | T489 | auxpass | was,confirmed |
R408 | T488 | T489 | advmod | also,confirmed |
R409 | T489 | T489 | ROOT | confirmed,confirmed |
R410 | T490 | T489 | prep | in,confirmed |
R411 | T491 | T492 | amod | Th2,cells |
R412 | T492 | T490 | pobj | cells,in |
R413 | T493 | T490 | cc | and,in |
R414 | T494 | T490 | conj | in,in |
R415 | T495 | T496 | compound | T,cells |
R416 | T496 | T494 | pobj | cells,in |
R417 | T497 | T496 | prep | of,cells |
R418 | T498 | T499 | amod | transgenic,mice |
R419 | T499 | T497 | pobj | mice,of |
R420 | T500 | T489 | advcl | overexpressing,confirmed |
R421 | T501 | T500 | dobj | GATA-3,overexpressing |
R422 | T502 | T500 | prep | in,overexpressing |
R423 | T503 | T504 | compound | T,cells |
R424 | T504 | T502 | pobj | cells,in |
R425 | T505 | T489 | punct | ",",confirmed |
R426 | T506 | T508 | nsubjpass | which,shown |
R427 | T507 | T508 | auxpass | are,shown |
R428 | T508 | T489 | advcl | shown,confirmed |
R429 | T509 | T510 | aux | to,be |
R430 | T510 | T508 | xcomp | be,shown |
R431 | T511 | T510 | acomp | deficient,be |
R432 | T512 | T511 | prep | in,deficient |
R433 | T513 | T512 | pcomp | transforming,in |
R434 | T514 | T515 | compound | growth,factor |
R435 | T515 | T513 | dobj | factor,transforming |
R436 | T516 | T517 | punct | (,TGF |
R437 | T517 | T515 | appos | TGF,factor |
R438 | T518 | T517 | punct | ),TGF |
R439 | T519 | T515 | punct | -,factor |
R440 | T520 | T515 | appos | β,factor |
R441 | T521 | T489 | conj | mediated,confirmed |
R442 | T522 | T523 | nummod | FOXP3,induction |
R443 | T523 | T521 | dobj | induction,mediated |
R444 | T524 | T489 | punct | .,confirmed |
R445 | T525 | T526 | det | This,inhibition |
R446 | T526 | T528 | nsubjpass | inhibition,mediated |
R447 | T527 | T528 | auxpass | is,mediated |
R448 | T528 | T528 | ROOT | mediated,mediated |
R449 | T529 | T528 | agent | by,mediated |
R450 | T530 | T531 | amod | direct,binding |
R451 | T531 | T529 | pobj | binding,by |
R452 | T532 | T531 | prep | of,binding |
R453 | T533 | T532 | pobj | GATA3,of |
R454 | T534 | T528 | prep | to,mediated |
R455 | T535 | T537 | det | the,promoter |
R456 | T536 | T537 | nummod | FOXP3,promoter |
R457 | T537 | T534 | pobj | promoter,to |
R458 | T538 | T537 | punct | ",",promoter |
R459 | T539 | T540 | nsubj | which,represses |
R460 | T540 | T537 | relcl | represses,promoter |
R461 | T541 | T543 | poss | its,process |
R462 | T542 | T543 | compound | transactivation,process |
R463 | T543 | T540 | dobj | process,represses |
R464 | T544 | T528 | punct | .,mediated |
R465 | T545 | T549 | advmod | Therefore,provides |
R466 | T546 | T549 | punct | ",",provides |
R467 | T547 | T548 | det | this,study |
R468 | T548 | T549 | nsubj | study,provides |
R469 | T549 | T549 | ROOT | provides,provides |
R470 | T550 | T552 | det | a,understanding |
R471 | T551 | T552 | amod | new,understanding |
R472 | T552 | T549 | dobj | understanding,provides |
R473 | T553 | T552 | prep | of,understanding |
R474 | T554 | T555 | compound | tolerance,development |
R475 | T555 | T553 | pobj | development,of |
R476 | T556 | T552 | punct | ",",understanding |
R477 | T557 | T552 | acl | controlled,understanding |
R478 | T558 | T557 | agent | by,controlled |
R479 | T559 | T563 | det | a,response |
R480 | T560 | T563 | nmod | type,response |
R481 | T561 | T560 | nummod | 2,type |
R482 | T562 | T563 | amod | immune,response |
R483 | T563 | T558 | pobj | response,by |
R484 | T564 | T549 | punct | .,provides |
R485 | T565 | T566 | compound | IL-4,treatment |
R486 | T566 | T569 | nsubj | treatment,reduces |
R487 | T567 | T566 | prep | in,treatment |
R488 | T568 | T567 | pobj | mice,in |
R489 | T569 | T569 | ROOT | reduces,reduces |
R490 | T570 | T572 | compound | iTreg,frequency |
R491 | T571 | T572 | compound | cell,frequency |
R492 | T572 | T569 | dobj | frequency,reduces |
R493 | T573 | T569 | punct | ",",reduces |
R494 | T574 | T569 | advcl | highlighting,reduces |
R495 | T575 | T584 | mark | that,provide |
R496 | T576 | T577 | amod | therapeutic,approaches |
R497 | T577 | T584 | nsubj | approaches,provide |
R498 | T578 | T579 | nsubj | that,target |
R499 | T579 | T577 | relcl | target,approaches |
R500 | T580 | T579 | dobj | IL-4,target |
R501 | T581 | T580 | cc | or,IL-4 |
R502 | T582 | T580 | conj | GATA3,IL-4 |
R503 | T583 | T584 | aux | might,provide |
R504 | T584 | T574 | ccomp | provide,highlighting |
R505 | T585 | T587 | amod | new,strategies |
R506 | T586 | T587 | amod | preventive,strategies |
R507 | T587 | T584 | dobj | strategies,provide |
R508 | T588 | T584 | advcl | facilitating,provide |
R509 | T589 | T590 | compound | tolerance,induction |
R510 | T590 | T588 | dobj | induction,facilitating |
R511 | T591 | T592 | advmod | particularly,in |
R512 | T592 | T590 | prep | in,induction |
R513 | T593 | T594 | amod | Th2-mediated,diseases |
R514 | T594 | T592 | pobj | diseases,in |
R515 | T595 | T594 | punct | ",",diseases |
R516 | T596 | T597 | amod | such,as |
R517 | T597 | T594 | prep | as,diseases |
R518 | T598 | T597 | pobj | allergy,as |
R519 | T599 | T569 | punct | .,reduces |
R322 | T402 | T403 | auxpass | were,shown |
R323 | T403 | T378 | conj | shown,act |
R324 | T404 | T405 | aux | to,be |
R325 | T405 | T403 | xcomp | be,shown |
R326 | T406 | T405 | acomp | critical,be |
R327 | T407 | T406 | prep | for,critical |
R328 | T408 | T407 | pobj | polarization,for |
R329 | T409 | T408 | prep | between,polarization |
R330 | T410 | T413 | nummod | Th1,phenotypes |
R331 | T411 | T410 | cc | and,Th1 |
R332 | T412 | T410 | conj | Th2,Th1 |
R333 | T413 | T409 | pobj | phenotypes,between |
R334 | T414 | T403 | punct | .,shown |
R335 | T415 | T416 | nsubj | FOXP3,is |
R336 | T416 | T443 | ccomp | is,are |
R337 | T417 | T420 | det | an,factor |
R338 | T418 | T420 | amod | essential,factor |
R339 | T419 | T420 | compound | transcription,factor |
R340 | T420 | T416 | attr | factor,is |
R341 | T421 | T420 | prep | for,factor |
R342 | T422 | T430 | amod | natural,Treg |
R343 | T423 | T422 | punct | ",",natural |
R344 | T424 | T422 | conj | thymus-derived,natural |
R345 | T425 | T426 | punct | (,nTreg |
R346 | T426 | T424 | appos | nTreg,thymus-derived |
R347 | T427 | T426 | punct | ),nTreg |
R348 | T428 | T424 | cc | and,thymus-derived |
R349 | T429 | T424 | conj | inducible,thymus-derived |
R350 | T430 | T421 | pobj | Treg,for |
R351 | T431 | T432 | punct | (,iTreg |
R352 | T432 | T430 | appos | iTreg,Treg |
R353 | T433 | T430 | punct | ),Treg |
R354 | T434 | T420 | conj | commitment,factor |
R355 | T435 | T443 | punct | ;,are |
R356 | T436 | T443 | advmod | however,are |
R357 | T437 | T443 | punct | ",",are |
R358 | T438 | T439 | det | the,mechanisms |
R359 | T439 | T443 | nsubj | mechanisms,are |
R360 | T440 | T439 | acl | regulating,mechanisms |
R361 | T441 | T442 | poss | its,expression |
R362 | T442 | T440 | dobj | expression,regulating |
R363 | T443 | T443 | ROOT | are,are |
R364 | T444 | T446 | advmod | as,unknown |
R365 | T445 | T446 | advmod | yet,unknown |
R366 | T446 | T443 | acomp | unknown,are |
R367 | T447 | T443 | punct | .,are |
R368 | T448 | T449 | nsubj | We,describe |
R369 | T449 | T449 | ROOT | describe,describe |
R370 | T450 | T451 | det | a,mechanism |
R371 | T451 | T454 | amod | mechanism,polarization |
R372 | T452 | T454 | amod | controlling,polarization |
R373 | T453 | T454 | compound | iTreg,polarization |
R374 | T454 | T449 | dobj | polarization,describe |
R375 | T455 | T454 | punct | ",",polarization |
R376 | T456 | T458 | nsubjpass | which,overruled |
R377 | T457 | T458 | auxpass | is,overruled |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T57 | 285-291 | http://purl.obolibrary.org/obo/UBERON_0002370 | denotes | thymus |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T68 | 0-13 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | Transcription |
T69 | 251-264 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T70 | 798-804 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
T71 | 944-959 | http://purl.obolibrary.org/obo/GO_2000144 | denotes | transactivation |
T72 | 1033-1044 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
T73 | 1069-1084 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
T74 | 1076-1090 | http://purl.obolibrary.org/obo/GO_0071353 | denotes | response. IL-4 |
T75 | 1076-1090 | http://purl.obolibrary.org/obo/GO_0070670 | denotes | response. IL-4 |
T76 | 1259-1278 | http://purl.obolibrary.org/obo/GO_0002507 | denotes | tolerance induction |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T631 | 561-566 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | 4 (IL |
T632 | 1086-1090 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
T633 | 1192-1196 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
T634 | 884-891 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T635 | 107-112 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T636 | 676-681 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T637 | 691-696 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T638 | 743-748 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T639 | 1123-1127 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T59 | 0-228 | Sentence | denotes | Transcription factors act in concert to induce lineage commitment towards Th1, Th2, or T regulatory (Treg) cells, and their counter-regulatory mechanisms were shown to be critical for polarization between Th1 and Th2 phenotypes. |
T60 | 229-416 | Sentence | denotes | FOXP3 is an essential transcription factor for natural, thymus-derived (nTreg) and inducible Treg (iTreg) commitment; however, the mechanisms regulating its expression are as yet unknown. |
T61 | 417-527 | Sentence | denotes | We describe a mechanism controlling iTreg polarization, which is overruled by the Th2 differentiation pathway. |
T62 | 528-623 | Sentence | denotes | We demonstrated that interleukin 4 (IL-4) present at the time of T cell priming inhibits FOXP3. |
T63 | 624-845 | Sentence | denotes | This inhibitory mechanism was also confirmed in Th2 cells and in T cells of transgenic mice overexpressing GATA-3 in T cells, which are shown to be deficient in transforming growth factor (TGF)-β–mediated FOXP3 induction. |
T64 | 846-968 | Sentence | denotes | This inhibition is mediated by direct binding of GATA3 to the FOXP3 promoter, which represses its transactivation process. |
T65 | 969-1085 | Sentence | denotes | Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. |
T66 | 1086-1334 | Sentence | denotes | IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy. |
T3 | 0-228 | Sentence | denotes | Transcription factors act in concert to induce lineage commitment towards Th1, Th2, or T regulatory (Treg) cells, and their counter-regulatory mechanisms were shown to be critical for polarization between Th1 and Th2 phenotypes. |
T4 | 229-416 | Sentence | denotes | FOXP3 is an essential transcription factor for natural, thymus-derived (nTreg) and inducible Treg (iTreg) commitment; however, the mechanisms regulating its expression are as yet unknown. |
T5 | 417-527 | Sentence | denotes | We describe a mechanism controlling iTreg polarization, which is overruled by the Th2 differentiation pathway. |
T6 | 528-623 | Sentence | denotes | We demonstrated that interleukin 4 (IL-4) present at the time of T cell priming inhibits FOXP3. |
T7 | 624-845 | Sentence | denotes | This inhibitory mechanism was also confirmed in Th2 cells and in T cells of transgenic mice overexpressing GATA-3 in T cells, which are shown to be deficient in transforming growth factor (TGF)-β–mediated FOXP3 induction. |
T8 | 846-968 | Sentence | denotes | This inhibition is mediated by direct binding of GATA3 to the FOXP3 promoter, which represses its transactivation process. |
T9 | 969-1085 | Sentence | denotes | Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. |
T10 | 1086-1334 | Sentence | denotes | IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy. |
ICD10
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T630 | 1326-1333 | http://purl.bioontology.org/ontology/ICD10/T78.4 | denotes | allergy |
events-check-again
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T768 | 785-819 | Protein | denotes | transforming growth factor (TGF)-β | |
T769 | 820-828 | Positive_regulation | denotes | mediated | |
T770 | 829-834 | Protein | denotes | FOXP3 | |
T771 | 835-844 | Positive_regulation | denotes | induction | |
T772 | 865-873 | Positive_regulation | denotes | mediated | |
T773 | 884-891 | Binding | denotes | binding | |
T774 | 895-900 | Protein | denotes | GATA3 | |
T775 | 908-913 | Protein | denotes | FOXP3 | |
T776 | 914-922 | Entity | denotes | promoter | |
T777 | 1086-1090 | Protein | denotes | IL-4 | |
T778 | 1185-1191 | Regulation | denotes | target | |
T779 | 1185-1191 | Regulation | denotes | target | |
T780 | 1192-1196 | Protein | denotes | IL-4 | |
T781 | 1200-1205 | Protein | denotes | GATA3 | |
T758 | 229-234 | Protein | denotes | FOXP3 | |
T759 | 371-381 | Regulation | denotes | regulating | true |
T760 | 386-396 | Gene_expression | denotes | expression | |
T761 | 549-562 | Protein | denotes | interleukin 4 | |
T762 | 564-568 | Protein | denotes | IL-4 | |
T763 | 608-616 | Negative_regulation | denotes | inhibits | |
T764 | 617-622 | Protein | denotes | FOXP3 | |
T765 | 716-730 | Gene_expression | denotes | overexpressing | |
T766 | 731-737 | Protein | denotes | GATA-3 | |
T767 | 772-781 | Negative_regulation | denotes | deficient | |
R607 | T780 | T778 | themeOf | IL-4,target | |
R608 | T781 | T779 | themeOf | GATA3,target | |
R658 | T760 | T759 | themeOf | expression,regulating | |
R660 | T762 | T761 | equivalentTo | IL-4,interleukin 4 | |
R599 | T768 | T769 | causeOf | transforming growth factor (TGF)-β,mediated | |
R600 | T769 | T767 | themeOf | mediated,deficient | |
R601 | T770 | T771 | themeOf | FOXP3,induction | |
R602 | T771 | T769 | themeOf | induction,mediated | |
R603 | T773 | T772 | causeOf | binding,mediated | |
R604 | T774 | T773 | themeOf | GATA3,binding | |
R605 | T776 | T773 | themeOf | promoter,binding | |
R606 | T776 | T775 | partOf | promoter,FOXP3 | |
R657 | T758 | T760 | themeOf | FOXP3,expression | |
R659 | T761 | T763 | causeOf | interleukin 4,inhibits | |
R661 | T764 | T763 | themeOf | FOXP3,inhibits | |
R662 | T766 | T765 | themeOf | GATA-3,overexpressing | |
R663 | T767 | T772 | themeOf | deficient,mediated |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T647 | 205-208 | Protein | denotes | Th1 |
T648 | 213-227 | Protein | denotes | Th2 phenotypes |
T649 | 229-234 | Protein | denotes | FOXP3 |
T650 | 386-396 | Gene_expression | denotes | expression |
T651 | 371-381 | Regulation | denotes | regulating |
T652 | 549-562 | Protein | denotes | interleukin 4 |
T653 | 564-568 | Protein | denotes | IL-4 |
T654 | 617-622 | Protein | denotes | FOXP3 |
T655 | 608-616 | Negative_regulation | denotes | inhibits |
T656 | 608-616 | Negative_regulation | denotes | inhibits |
T657 | 731-737 | Protein | denotes | GATA-3 |
T658 | 829-834 | Protein | denotes | FOXP3 |
T659 | 716-730 | Gene_expression | denotes | overexpressing |
T660 | 835-844 | Positive_regulation | denotes | induction |
T661 | 772-781 | Negative_regulation | denotes | deficient |
T662 | 895-900 | Protein | denotes | GATA3 |
T663 | 908-922 | Protein | denotes | FOXP3 promoter |
T664 | 884-891 | Binding | denotes | binding |
T665 | 884-891 | Binding | denotes | binding |
T666 | 1086-1090 | Protein | denotes | IL-4 |
T667 | 1185-1196 | Protein | denotes | target IL-4 |
T668 | 1200-1205 | Protein | denotes | GATA3 |
R555 | T662 | T665 | themeOf | GATA3,binding |
R556 | T663 | T665 | themeOf | FOXP3 promoter,binding |
R545 | T649 | T650 | themeOf | FOXP3,expression |
R546 | T650 | T651 | themeOf | expression,regulating |
R547 | T652 | T655 | causeOf | interleukin 4,inhibits |
R548 | T653 | T656 | causeOf | IL-4,inhibits |
R549 | T654 | T655 | themeOf | FOXP3,inhibits |
R550 | T654 | T656 | themeOf | FOXP3,inhibits |
R551 | T657 | T659 | themeOf | GATA-3,overexpressing |
R552 | T658 | T660 | themeOf | FOXP3,induction |
R553 | T660 | T661 | themeOf | induction,deficient |
R554 | T662 | T664 | themeOf | GATA3,binding |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T102 | 549-562 | Protein | denotes | interleukin 4 | |
T103 | 564-568 | Protein | denotes | IL-4 | |
T104 | 617-622 | Protein | denotes | FOXP3 | |
T105 | 731-737 | Protein | denotes | GATA-3 | |
T106 | 785-819 | Protein | denotes | transforming growth factor (TGF)-β | |
T78 | 835-844 | Positive_regulation | denotes | induction | |
T79 | 865-873 | Positive_regulation | denotes | mediated | |
T80 | 884-891 | Binding | denotes | binding | |
T81 | 1185-1191 | Regulation | denotes | target | |
T82 | 1185-1191 | Regulation | denotes | target | |
T85 | 371-381 | Regulation | denotes | regulating | true |
T86 | 386-396 | Gene_expression | denotes | expression | |
T87 | 608-616 | Negative_regulation | denotes | inhibits | |
T88 | 716-730 | Gene_expression | denotes | overexpressing | |
T89 | 772-781 | Negative_regulation | denotes | deficient | |
T90 | 820-828 | Positive_regulation | denotes | mediated | |
T92 | 829-834 | Protein | denotes | FOXP3 | |
T93 | 895-900 | Protein | denotes | GATA3 | |
T94 | 908-913 | Protein | denotes | FOXP3 | |
T95 | 1086-1090 | Protein | denotes | IL-4 | |
T96 | 1192-1196 | Protein | denotes | IL-4 | |
T97 | 1200-1205 | Protein | denotes | GATA3 | |
T100 | 914-922 | Entity | denotes | promoter | |
T101 | 229-234 | Protein | denotes | FOXP3 | |
R622 | T86 | T85 | themeOf | expression,regulating | |
R623 | T89 | T79 | themeOf | deficient,mediated | |
R624 | T90 | T89 | themeOf | mediated,deficient | |
R625 | T92 | T78 | themeOf | FOXP3,induction | |
R626 | T93 | T80 | themeOf | GATA3,binding | |
R627 | T96 | T81 | themeOf | IL-4,target | |
R628 | T97 | T82 | themeOf | GATA3,target | |
R631 | T100 | T80 | themeOf | promoter,binding | |
R632 | T100 | T94 | partOf | promoter,FOXP3 | |
R633 | T101 | T86 | themeOf | FOXP3,expression | |
R39 | T102 | T87 | causeOf | interleukin 4,inhibits | |
R40 | T103 | T102 | equivalentTo | IL-4,interleukin 4 | |
R41 | T104 | T87 | themeOf | FOXP3,inhibits | |
R42 | T105 | T88 | themeOf | GATA-3,overexpressing | |
R43 | T106 | T90 | causeOf | transforming growth factor (TGF)-β,mediated | |
R618 | T78 | T90 | themeOf | induction,mediated | |
R619 | T80 | T79 | causeOf | binding,mediated |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T341 | 229-234 | Q9BZS1 | denotes | FOXP3 |
T342 | 549-562 | P05112 | denotes | interleukin 4 |
T343 | 564-568 | P05112 | denotes | IL-4 |
T344 | 617-622 | Q9BZS1 | denotes | FOXP3 |
T345 | 731-737 | P23771 | denotes | GATA-3 |
T346 | 829-834 | Q9BZS1 | denotes | FOXP3 |
T347 | 895-900 | P23771 | denotes | GATA3 |
T348 | 908-913 | Q9BZS1 | denotes | FOXP3 |
T349 | 1086-1090 | P05112 | denotes | IL-4 |
T350 | 1192-1196 | P05112 | denotes | IL-4 |
T351 | 1200-1205 | P23771 | denotes | GATA3 |
test2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T37 | 229-234 | Protein | denotes | FOXP3 |
T38 | 549-562 | Protein | denotes | interleukin 4 |
T39 | 564-568 | Protein | denotes | IL-4 |
T40 | 608-616 | Negative_regulation | denotes | inhibits |
T41 | 617-622 | Protein | denotes | FOXP3 |
T42 | 716-730 | Gene_expression | denotes | overexpressing |
T43 | 731-737 | Protein | denotes | GATA-3 |
T44 | 772-781 | Negative_regulation | denotes | deficient |
T45 | 785-819 | Protein | denotes | transforming growth factor (TGF)-β |
T46 | 820-828 | Positive_regulation | denotes | mediated |
T47 | 829-834 | Protein | denotes | FOXP3 |
T48 | 835-844 | Positive_regulation | denotes | induction |
T49 | 884-891 | Binding | denotes | binding |
T50 | 895-900 | Protein | denotes | GATA3 |
T51 | 908-913 | Protein | denotes | FOXP3 |
T52 | 914-922 | Entity | denotes | promoter |
T53 | 1086-1090 | Protein | denotes | IL-4 |
T54 | 1185-1191 | Binding | denotes | target |
T55 | 1192-1196 | Protein | denotes | IL-4 |
T56 | 1200-1205 | Protein | denotes | GATA3 |
R27 | T38 | T40 | causeOf | interleukin 4,inhibits |
R28 | T39 | T38 | equivalentTo | IL-4,interleukin 4 |
R29 | T41 | T40 | themeOf | FOXP3,inhibits |
R30 | T43 | T42 | themeOf | GATA-3,overexpressing |
R31 | T47 | T48 | themeOf | FOXP3,induction |
R32 | T48 | T46 | themeOf | induction,mediated |
R33 | T50 | T49 | themeOf | GATA3,binding |
R34 | T52 | T51 | partOf | promoter,FOXP3 |
R35 | T52 | T49 | themeOf | promoter,binding |
R36 | T53 | T54 | themeOf | IL-4,target |
R37 | T55 | T54 | themeOf | IL-4,target |
R38 | T56 | T54 | themeOf | GATA3,target |