PMC:2222968 / 1495-2545 JSONTXT

{"project":"sentences","denotations":[{"id":"T11","span":{"begin":0,"end":14},"obj":"Sentence"},{"id":"T12","span":{"begin":16,"end":229},"obj":"Sentence"},{"id":"T13","span":{"begin":230,"end":449},"obj":"Sentence"},{"id":"T14","span":{"begin":450,"end":582},"obj":"Sentence"},{"id":"T15","span":{"begin":583,"end":714},"obj":"Sentence"},{"id":"T16","span":{"begin":715,"end":833},"obj":"Sentence"},{"id":"T17","span":{"begin":834,"end":1049},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Author Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain T cell phenotypes such as pro-inflammatory cells (Th1, Th2, Th17) or regulatory T (Treg) cells, which serve to keep the immune response in check. The current study focuses on the role of two key transcription factors—FOXP3 and GATA3—in controlling the commitment of these cells. We demonstrate that the Th2 cytokine IL-4 inhibits the induction of FOXP3 and thus inhibits the generation of inducible Treg cells. We show that IL-4–induced GATA3 mediates FOXP3 inhibition by directly binding to a GATA element in the FOXP3 promoter. We hypothesize that therapeutic agents aimed at neutralizing IL-4 could be a novel strategy to facilitate inducible Treg cell generation and thus promotion of tolerance in allergies and other Th2-dominated diseases.\n"}