| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T11 |
0-14 |
Sentence |
denotes |
Author Summary |
| T12 |
16-229 |
Sentence |
denotes |
Specific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. |
| T13 |
230-449 |
Sentence |
denotes |
The subsequent maturation process involves the differentiation of certain T cell phenotypes such as pro-inflammatory cells (Th1, Th2, Th17) or regulatory T (Treg) cells, which serve to keep the immune response in check. |
| T14 |
450-582 |
Sentence |
denotes |
The current study focuses on the role of two key transcription factors—FOXP3 and GATA3—in controlling the commitment of these cells. |
| T15 |
583-714 |
Sentence |
denotes |
We demonstrate that the Th2 cytokine IL-4 inhibits the induction of FOXP3 and thus inhibits the generation of inducible Treg cells. |
| T16 |
715-833 |
Sentence |
denotes |
We show that IL-4–induced GATA3 mediates FOXP3 inhibition by directly binding to a GATA element in the FOXP3 promoter. |
| T17 |
834-1049 |
Sentence |
denotes |
We hypothesize that therapeutic agents aimed at neutralizing IL-4 could be a novel strategy to facilitate inducible Treg cell generation and thus promotion of tolerance in allergies and other Th2-dominated diseases. |
