PMC:2065877 / 604-1125
Annnotations
pmc-enju-pas
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Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling. These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition. These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas.\n\nAuthor Summary\n\nEpstein-Barr virus (EBV) is linked to the development of multiple cancers, including "}
bionlp-st-ge-2016-coref
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bionlp-st-ge-2016-spacy-parsed
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cells in vitro. Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling. These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition. These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas.\n\nAuthor Summary\n\nEpstein-Barr virus (EBV) is linked to the development of multiple cancers, including "}
GO-BP
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GO-CC
{"project":"GO-CC","denotations":[{"id":"T427","span":{"begin":4,"end":9},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T428","span":{"begin":29,"end":34},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T429","span":{"begin":403,"end":407},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"oma cells in vitro. Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling. These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition. These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas.\n\nAuthor Summary\n\nEpstein-Barr virus (EBV) is linked to the development of multiple cancers, including "}
sentences
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events-check-again
{"project":"events-check-again","denotations":[{"id":"T508","span":{"begin":54,"end":57},"obj":"Protein"},{"id":"T509","span":{"begin":58,"end":63},"obj":"Protein"},{"id":"T510","span":{"begin":140,"end":145},"obj":"Protein"},{"id":"T511","span":{"begin":185,"end":196},"obj":"Regulation"},{"id":"T512","span":{"begin":185,"end":196},"obj":"Regulation"},{"id":"T513","span":{"begin":185,"end":196},"obj":"Regulation"},{"id":"T514","span":{"begin":305,"end":308},"obj":"Protein"},{"id":"T515","span":{"begin":320,"end":325},"obj":"Protein"}],"relations":[{"id":"R375","pred":"themeOf","subj":"T508","obj":"T513"},{"id":"R376","pred":"themeOf","subj":"T509","obj":"T511"},{"id":"R377","pred":"themeOf","subj":"T510","obj":"T512"}],"attributes":[{"id":"M16","pred":"Negation","subj":"T511","obj":"true"},{"id":"M17","pred":"Negation","subj":"T512","obj":"true"},{"id":"M18","pred":"Negation","subj":"T513","obj":"true"}],"text":"oma cells in vitro. Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling. These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition. These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas.\n\nAuthor Summary\n\nEpstein-Barr virus (EBV) is linked to the development of multiple cancers, including "}
bionlp-st-ge-2016-reference-tees
{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T489","span":{"begin":54,"end":57},"obj":"Protein"},{"id":"T490","span":{"begin":58,"end":63},"obj":"Protein"},{"id":"T491","span":{"begin":140,"end":145},"obj":"Protein"},{"id":"T492","span":{"begin":305,"end":308},"obj":"Protein"},{"id":"T493","span":{"begin":310,"end":314},"obj":"Protein"},{"id":"T494","span":{"begin":320,"end":325},"obj":"Protein"}],"text":"oma cells in vitro. Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling. These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition. These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas.\n\nAuthor Summary\n\nEpstein-Barr virus (EBV) is linked to the development of multiple cancers, including "}
bionlp-st-ge-2016-reference
{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T57","span":{"begin":305,"end":308},"obj":"Protein"},{"id":"T58","span":{"begin":320,"end":325},"obj":"Protein"},{"id":"T51","span":{"begin":54,"end":57},"obj":"Protein"},{"id":"T52","span":{"begin":58,"end":63},"obj":"Protein"},{"id":"T53","span":{"begin":140,"end":145},"obj":"Protein"},{"id":"T54","span":{"begin":185,"end":196},"obj":"Regulation"},{"id":"T55","span":{"begin":185,"end":196},"obj":"Regulation"},{"id":"T56","span":{"begin":185,"end":196},"obj":"Regulation"}],"relations":[{"id":"R352","pred":"themeOf","subj":"T51","obj":"T56"},{"id":"R353","pred":"themeOf","subj":"T52","obj":"T54"},{"id":"R354","pred":"themeOf","subj":"T53","obj":"T55"}],"attributes":[{"id":"M12","pred":"Negation","subj":"T56","obj":"true"},{"id":"M10","pred":"Negation","subj":"T54","obj":"true"},{"id":"M11","pred":"Negation","subj":"T55","obj":"true"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"oma cells in vitro. Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling. These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition. These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas.\n\nAuthor Summary\n\nEpstein-Barr virus (EBV) is linked to the development of multiple cancers, including "}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T249","span":{"begin":305,"end":308},"obj":"P31749"},{"id":"T250","span":{"begin":305,"end":308},"obj":"P31751"},{"id":"T251","span":{"begin":305,"end":308},"obj":"Q9Y243"},{"id":"T252","span":{"begin":320,"end":325},"obj":"P40763"},{"id":"T246","span":{"begin":54,"end":57},"obj":"P05112"},{"id":"T247","span":{"begin":58,"end":63},"obj":"P42226"},{"id":"T248","span":{"begin":140,"end":145},"obj":"P40763"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"oma cells in vitro. Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling. These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition. These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas.\n\nAuthor Summary\n\nEpstein-Barr virus (EBV) is linked to the development of multiple cancers, including "}
test2
{"project":"test2","denotations":[{"id":"T32","span":{"begin":54,"end":57},"obj":"Protein"},{"id":"T33","span":{"begin":58,"end":63},"obj":"Protein"},{"id":"T34","span":{"begin":130,"end":139},"obj":"Positive_regulation"},{"id":"T35","span":{"begin":140,"end":145},"obj":"Protein"},{"id":"T36","span":{"begin":305,"end":308},"obj":"Protein"},{"id":"T37","span":{"begin":320,"end":325},"obj":"Protein"}],"text":"oma cells in vitro. Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling. These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition. These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas.\n\nAuthor Summary\n\nEpstein-Barr virus (EBV) is linked to the development of multiple cancers, including "}