PMC:2065877 / 604-1125
Annnotations
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T168 | 4-9 | NN | denotes | cells |
T169 | 10-12 | FW | denotes | in |
T170 | 13-18 | FW | denotes | vitro |
T171 | 20-28 | NN | denotes | Lymphoma |
T172 | 29-34 | NN | denotes | cells |
T173 | 35-38 | VB | denotes | are |
T174 | 39-50 | JJ | denotes | independent |
T175 | 51-53 | IN | denotes | of |
T176 | 54-63 | NN | denotes | IL4/Stat6 |
T177 | 64-73 | NN | denotes | signaling |
T178 | 74-77 | IN | denotes | for |
T179 | 78-86 | NN | denotes | survival |
T180 | 87-90 | CC | denotes | and |
T181 | 91-104 | NN | denotes | proliferation |
T182 | 104-105 | -COMMA- | denotes | , |
T183 | 106-109 | CC | denotes | but |
T184 | 110-114 | VB | denotes | have |
T185 | 115-129 | RB | denotes | constitutively |
T186 | 130-139 | VB | denotes | activated |
T187 | 140-145 | NN | denotes | Stat3 |
T188 | 146-155 | NN | denotes | signaling |
T189 | 157-162 | DT | denotes | These |
T190 | 163-167 | JJ | denotes | same |
T191 | 168-175 | NN | denotes | targets |
T192 | 176-179 | VB | denotes | are |
T193 | 180-184 | RB | denotes | also |
T194 | 185-196 | VB | denotes | deregulated |
T195 | 197-199 | IN | denotes | in |
T196 | 200-209 | JJ | denotes | wild-type |
T197 | 210-214 | NN | denotes | B-1a |
T198 | 215-224 | NN | denotes | lymphomas |
T199 | 225-229 | WDT | denotes | that |
T200 | 230-235 | VB | denotes | arise |
T201 | 236-249 | RB | denotes | spontaneously |
T202 | 250-257 | IN | denotes | through |
T203 | 258-261 | NN | denotes | age |
T204 | 262-276 | NN | denotes | predisposition |
T205 | 278-283 | DT | denotes | These |
T206 | 284-291 | NN | denotes | results |
T207 | 292-299 | VB | denotes | suggest |
T208 | 300-304 | IN | denotes | that |
T209 | 305-308 | NN | denotes | Akt |
T210 | 308-309 | -COMMA- | denotes | , |
T211 | 310-314 | NN | denotes | NFκB |
T212 | 314-315 | -COMMA- | denotes | , |
T213 | 316-319 | CC | denotes | and |
T214 | 320-325 | NN | denotes | Stat3 |
T215 | 326-334 | NN | denotes | pathways |
T216 | 335-338 | MD | denotes | may |
T217 | 339-344 | VB | denotes | serve |
T218 | 345-347 | IN | denotes | as |
T219 | 348-357 | JJ | denotes | effective |
T220 | 358-365 | NN | denotes | targets |
T221 | 366-368 | IN | denotes | in |
T222 | 369-372 | DT | denotes | the |
T223 | 373-382 | NN | denotes | treatment |
T224 | 383-385 | IN | denotes | of |
T225 | 386-400 | JJ | denotes | EBV-associated |
T226 | 401-402 | NN | denotes | B |
T227 | 403-407 | NN | denotes | cell |
T228 | 408-417 | NN | denotes | lymphomas |
R106 | T170 | T169 | arg1Of | vitro,in |
R107 | T172 | T171 | arg1Of | cells,Lymphoma |
R108 | T172 | T173 | arg1Of | cells,are |
R109 | T172 | T174 | arg1Of | cells,independent |
R110 | T172 | T184 | arg1Of | cells,have |
R111 | T172 | T186 | arg1Of | cells,activated |
R112 | T173 | T183 | arg1Of | are,but |
R113 | T174 | T173 | arg2Of | independent,are |
R114 | T174 | T175 | arg1Of | independent,of |
R115 | T177 | T175 | arg2Of | signaling,of |
R116 | T177 | T176 | arg1Of | signaling,IL4/Stat6 |
R117 | T177 | T178 | arg1Of | signaling,for |
R118 | T179 | T180 | arg1Of | survival,and |
R119 | T180 | T178 | arg2Of | and,for |
R120 | T181 | T180 | arg2Of | proliferation,and |
R121 | T183 | T182 | arg1Of | but,"," |
R122 | T186 | T183 | arg2Of | activated,but |
R123 | T186 | T184 | arg2Of | activated,have |
R124 | T186 | T185 | arg1Of | activated,constitutively |
R125 | T188 | T186 | arg2Of | signaling,activated |
R126 | T188 | T187 | arg1Of | signaling,Stat3 |
R127 | T191 | T189 | arg1Of | targets,These |
R128 | T191 | T190 | arg1Of | targets,same |
R129 | T191 | T192 | arg1Of | targets,are |
R130 | T191 | T194 | arg2Of | targets,deregulated |
R131 | T194 | T192 | arg2Of | deregulated,are |
R132 | T194 | T193 | arg1Of | deregulated,also |
R133 | T194 | T195 | arg1Of | deregulated,in |
R134 | T198 | T195 | arg2Of | lymphomas,in |
R135 | T198 | T196 | arg1Of | lymphomas,wild-type |
R136 | T198 | T197 | arg1Of | lymphomas,B-1a |
R137 | T198 | T199 | arg1Of | lymphomas,that |
R138 | T198 | T200 | arg1Of | lymphomas,arise |
R139 | T200 | T201 | arg1Of | arise,spontaneously |
R140 | T200 | T202 | arg1Of | arise,through |
R141 | T204 | T202 | arg2Of | predisposition,through |
R142 | T204 | T203 | arg1Of | predisposition,age |
R143 | T206 | T205 | arg1Of | results,These |
R144 | T206 | T207 | arg1Of | results,suggest |
R145 | T209 | T210 | arg1Of | Akt,"," |
R146 | T210 | T213 | arg1Of | ",",and |
R147 | T211 | T210 | arg2Of | NFκB,"," |
R148 | T213 | T212 | arg1Of | and,"," |
R149 | T213 | T216 | arg1Of | and,may |
R150 | T213 | T217 | arg1Of | and,serve |
R151 | T215 | T213 | arg2Of | pathways,and |
R152 | T215 | T214 | arg1Of | pathways,Stat3 |
R153 | T217 | T207 | arg2Of | serve,suggest |
R154 | T217 | T208 | arg1Of | serve,that |
R155 | T217 | T216 | arg2Of | serve,may |
R156 | T217 | T218 | arg1Of | serve,as |
R157 | T220 | T218 | arg2Of | targets,as |
R158 | T220 | T219 | arg1Of | targets,effective |
R159 | T220 | T221 | arg1Of | targets,in |
R160 | T223 | T221 | arg2Of | treatment,in |
R161 | T223 | T222 | arg1Of | treatment,the |
R162 | T223 | T224 | arg1Of | treatment,of |
R163 | T228 | T224 | arg2Of | lymphomas,of |
R164 | T228 | T225 | arg1Of | lymphomas,EBV-associated |
R165 | T228 | T226 | arg1Of | lymphomas,B |
R166 | T228 | T227 | arg1Of | lymphomas,cell |
bionlp-st-ge-2016-coref
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T229 | 157-175 | Anaphor | denotes | These same targets |
T230 | 54-57 | Antecedent | denotes | IL4 |
T231 | 58-63 | Antecedent | denotes | Stat6 |
T232 | 140-145 | Antecedent | denotes | Stat3 |
R355 | T229 | T230 | boundBy | These same targets,IL4 |
R356 | T229 | T231 | boundBy | These same targets,Stat6 |
R357 | T229 | T232 | boundBy | These same targets,Stat3 |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T351 | 4-9 | NNS | denotes | cells |
T352 | 10-12 | IN | denotes | in |
T353 | 13-18 | NN | denotes | vitro |
T354 | 18-19 | . | denotes | . |
T355 | 20-28 | NNP | denotes | Lymphoma |
T356 | 29-34 | NNS | denotes | cells |
T357 | 35-38 | VBP | denotes | are |
T358 | 39-50 | JJ | denotes | independent |
T359 | 51-53 | IN | denotes | of |
T360 | 54-63 | NNP | denotes | IL4/Stat6 |
T361 | 64-73 | VBG | denotes | signaling |
T362 | 74-77 | IN | denotes | for |
T363 | 78-86 | NN | denotes | survival |
T364 | 87-90 | CC | denotes | and |
T365 | 91-104 | NN | denotes | proliferation |
T366 | 104-105 | , | denotes | , |
T367 | 106-109 | CC | denotes | but |
T368 | 110-114 | VBP | denotes | have |
T369 | 115-129 | RB | denotes | constitutively |
T370 | 130-139 | VBN | denotes | activated |
T371 | 140-145 | JJ | denotes | Stat3 |
T372 | 146-155 | VBG | denotes | signaling |
T373 | 155-156 | . | denotes | . |
T374 | 157-162 | DT | denotes | These |
T375 | 163-167 | JJ | denotes | same |
T376 | 168-175 | NNS | denotes | targets |
T377 | 176-179 | VBP | denotes | are |
T378 | 180-184 | RB | denotes | also |
T379 | 185-196 | VBN | denotes | deregulated |
T380 | 197-199 | IN | denotes | in |
T381 | 200-209 | JJ | denotes | wild-type |
T382 | 210-214 | NN | denotes | B-1a |
T383 | 215-224 | NNS | denotes | lymphomas |
T384 | 225-229 | WDT | denotes | that |
T385 | 230-235 | VBP | denotes | arise |
T386 | 236-249 | RB | denotes | spontaneously |
T387 | 250-257 | IN | denotes | through |
T388 | 258-261 | NN | denotes | age |
T389 | 262-276 | NN | denotes | predisposition |
T390 | 276-277 | . | denotes | . |
T391 | 278-283 | DT | denotes | These |
T392 | 284-291 | NNS | denotes | results |
T393 | 292-299 | VBP | denotes | suggest |
T394 | 300-304 | IN | denotes | that |
T395 | 305-308 | NNP | denotes | Akt |
T396 | 308-309 | , | denotes | , |
T397 | 310-314 | NNP | denotes | NFκB |
T398 | 314-315 | , | denotes | , |
T399 | 316-319 | CC | denotes | and |
T400 | 320-325 | JJ | denotes | Stat3 |
T401 | 326-334 | NNS | denotes | pathways |
T402 | 335-338 | MD | denotes | may |
T403 | 339-344 | VB | denotes | serve |
T404 | 345-347 | IN | denotes | as |
T405 | 348-357 | JJ | denotes | effective |
T406 | 358-365 | NNS | denotes | targets |
T407 | 366-368 | IN | denotes | in |
T408 | 369-372 | DT | denotes | the |
T409 | 373-382 | NN | denotes | treatment |
T410 | 383-385 | IN | denotes | of |
T411 | 386-400 | JJ | denotes | EBV-associated |
T412 | 401-402 | NNP | denotes | B |
T413 | 403-407 | NN | denotes | cell |
T414 | 408-417 | NNS | denotes | lymphomas |
T415 | 417-418 | . | denotes | . |
R265 | T353 | T352 | pobj | vitro,in |
R267 | T355 | T356 | compound | Lymphoma,cells |
R268 | T356 | T357 | nsubj | cells,are |
R269 | T357 | T357 | ROOT | are,are |
R270 | T358 | T357 | acomp | independent,are |
R271 | T359 | T358 | prep | of,independent |
R272 | T360 | T359 | pobj | IL4/Stat6,of |
R273 | T361 | T357 | advcl | signaling,are |
R274 | T362 | T361 | prep | for,signaling |
R275 | T363 | T362 | pobj | survival,for |
R276 | T364 | T363 | cc | and,survival |
R277 | T365 | T363 | conj | proliferation,survival |
R278 | T366 | T357 | punct | ",",are |
R279 | T367 | T357 | cc | but,are |
R280 | T368 | T370 | aux | have,activated |
R281 | T369 | T370 | advmod | constitutively,activated |
R282 | T370 | T357 | conj | activated,are |
R283 | T371 | T372 | amod | Stat3,signaling |
R284 | T372 | T370 | dobj | signaling,activated |
R285 | T373 | T357 | punct | .,are |
R286 | T374 | T376 | det | These,targets |
R287 | T375 | T376 | amod | same,targets |
R288 | T376 | T379 | nsubjpass | targets,deregulated |
R289 | T377 | T379 | auxpass | are,deregulated |
R290 | T378 | T379 | advmod | also,deregulated |
R291 | T379 | T379 | ROOT | deregulated,deregulated |
R292 | T380 | T379 | prep | in,deregulated |
R293 | T381 | T383 | amod | wild-type,lymphomas |
R294 | T382 | T383 | compound | B-1a,lymphomas |
R295 | T383 | T380 | pobj | lymphomas,in |
R296 | T384 | T385 | nsubj | that,arise |
R297 | T385 | T383 | relcl | arise,lymphomas |
R298 | T386 | T385 | advmod | spontaneously,arise |
R299 | T387 | T385 | prep | through,arise |
R300 | T388 | T389 | compound | age,predisposition |
R301 | T389 | T387 | pobj | predisposition,through |
R302 | T390 | T379 | punct | .,deregulated |
R303 | T391 | T392 | det | These,results |
R304 | T392 | T393 | nsubj | results,suggest |
R305 | T393 | T393 | ROOT | suggest,suggest |
R306 | T394 | T403 | mark | that,serve |
R307 | T395 | T403 | nsubj | Akt,serve |
R308 | T396 | T395 | punct | ",",Akt |
R309 | T397 | T395 | conj | NFκB,Akt |
R310 | T398 | T397 | punct | ",",NFκB |
R311 | T399 | T397 | cc | and,NFκB |
R312 | T400 | T401 | amod | Stat3,pathways |
R313 | T401 | T397 | conj | pathways,NFκB |
R314 | T402 | T403 | aux | may,serve |
R315 | T403 | T393 | ccomp | serve,suggest |
R316 | T404 | T403 | prep | as,serve |
R317 | T405 | T406 | amod | effective,targets |
R318 | T406 | T404 | pobj | targets,as |
R319 | T407 | T406 | prep | in,targets |
R320 | T408 | T409 | det | the,treatment |
R321 | T409 | T407 | pobj | treatment,in |
R322 | T410 | T409 | prep | of,treatment |
R323 | T411 | T414 | amod | EBV-associated,lymphomas |
R324 | T412 | T413 | compound | B,cell |
R325 | T413 | T414 | compound | cell,lymphomas |
R326 | T414 | T410 | pobj | lymphomas,of |
R327 | T415 | T393 | punct | .,suggest |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T69 | 258-261 | http://purl.obolibrary.org/obo/GO_0007568 | denotes | age |
T71 | 64-73 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T72 | 146-155 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T427 | 4-9 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T428 | 29-34 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T429 | 403-407 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T64 | 20-156 | Sentence | denotes | Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling. |
T65 | 157-277 | Sentence | denotes | These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition. |
T66 | 278-418 | Sentence | denotes | These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas. |
T7 | 20-156 | Sentence | denotes | Lymphoma cells are independent of IL4/Stat6 signaling for survival and proliferation, but have constitutively activated Stat3 signaling. |
T8 | 157-277 | Sentence | denotes | These same targets are also deregulated in wild-type B-1a lymphomas that arise spontaneously through age predisposition. |
T9 | 278-418 | Sentence | denotes | These results suggest that Akt, NFκB, and Stat3 pathways may serve as effective targets in the treatment of EBV-associated B cell lymphomas. |
T10 | 420-434 | Sentence | denotes | Author Summary |
events-check-again
Id | Subject | Object | Predicate | Lexical cue | Negation |
---|---|---|---|---|---|
T508 | 54-57 | Protein | denotes | IL4 | |
T509 | 58-63 | Protein | denotes | Stat6 | |
T510 | 140-145 | Protein | denotes | Stat3 | |
T511 | 185-196 | Regulation | denotes | deregulated | true |
T512 | 185-196 | Regulation | denotes | deregulated | true |
T513 | 185-196 | Regulation | denotes | deregulated | true |
T514 | 305-308 | Protein | denotes | Akt | |
T515 | 320-325 | Protein | denotes | Stat3 | |
R375 | T508 | T513 | themeOf | IL4,deregulated | |
R376 | T509 | T511 | themeOf | Stat6,deregulated | |
R377 | T510 | T512 | themeOf | Stat3,deregulated |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T489 | 54-57 | Protein | denotes | IL4 |
T490 | 58-63 | Protein | denotes | Stat6 |
T491 | 140-145 | Protein | denotes | Stat3 |
T492 | 305-308 | Protein | denotes | Akt |
T493 | 310-314 | Protein | denotes | NFκB |
T494 | 320-325 | Protein | denotes | Stat3 |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue | Negation |
---|---|---|---|---|---|
T57 | 305-308 | Protein | denotes | Akt | |
T58 | 320-325 | Protein | denotes | Stat3 | |
T51 | 54-57 | Protein | denotes | IL4 | |
T52 | 58-63 | Protein | denotes | Stat6 | |
T53 | 140-145 | Protein | denotes | Stat3 | |
T54 | 185-196 | Regulation | denotes | deregulated | true |
T55 | 185-196 | Regulation | denotes | deregulated | true |
T56 | 185-196 | Regulation | denotes | deregulated | true |
R352 | T51 | T56 | themeOf | IL4,deregulated | |
R353 | T52 | T54 | themeOf | Stat6,deregulated | |
R354 | T53 | T55 | themeOf | Stat3,deregulated |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T249 | 305-308 | P31749 | denotes | Akt |
T250 | 305-308 | P31751 | denotes | Akt |
T251 | 305-308 | Q9Y243 | denotes | Akt |
T252 | 320-325 | P40763 | denotes | Stat3 |
T246 | 54-57 | P05112 | denotes | IL4 |
T247 | 58-63 | P42226 | denotes | Stat6 |
T248 | 140-145 | P40763 | denotes | Stat3 |
test2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T32 | 54-57 | Protein | denotes | IL4 |
T33 | 58-63 | Protein | denotes | Stat6 |
T34 | 130-139 | Positive_regulation | denotes | activated |
T35 | 140-145 | Protein | denotes | Stat3 |
T36 | 305-308 | Protein | denotes | Akt |
T37 | 320-325 | Protein | denotes | Stat3 |