PMC:194730 / 1843-2543 JSONTXT

Annnotations TAB JSON ListView MergeView

    craft-sa-dev

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A7 is a Ca2+- and phospholipid-binding protein, which was isolated as the agent that mediated aggregation of chromaffin granules and fusion of phospholipid membranes in the presence of Ca2+. 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    craft-ca-core-dev

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    2_test

    {"project":"2_test","denotations":[{"id":"12925238-632306-8102376","span":{"begin":308,"end":309},"obj":"632306"},{"id":"12925238-8155692-8102377","span":{"begin":607,"end":608},"obj":"8155692"},{"id":"12925238-9223619-8102377","span":{"begin":607,"end":608},"obj":"9223619"},{"id":"12925238-11917092-8102377","span":{"begin":607,"end":608},"obj":"11917092"}],"text":"Annexin A7 is a Ca2+- and phospholipid-binding protein, which was isolated as the agent that mediated aggregation of chromaffin granules and fusion of phospholipid membranes in the presence of Ca2+. This activity led to the proposal of annexin A7's involvement in the exocytotic secretion of catecholamines [1]. The protein belongs to a family of evolutionarily conserved proteins of a bipartite structure with a variable N-terminal and a conserved C-terminal domain. The C-terminal domain is responsible for the Ca2+- and phospholipid-binding, the N-terminal domain appears to confer functional diversity [2-4]. The binding to negatively charged phospholipids is thought to be mediated by Ca2+ ions."}

    craft-ca-core-ex-dev

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