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investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A., Liu, P., Spitaler, M., Olson, E.N., McKinsey, T.A., Cantrell, D.A. and Scharenberg, A.M. (2006) Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol. Cell Biol. 26, 1569–1577]. We now show that PKDs are also required to regulate HSP27 phosphorylation in DT40 B-cells. However, in contrast to previous observations in other cell types, PKD enzymes do not regulate basic cellular processes such as proliferation or survival responses, nor NFκB transcriptional activity downstream of the B cell antigen receptor. Thus, PKDs have a selective role in DT40 B-cell biology.\n"}

{"project":"GO-BP","denotations":[{"id":"T21","span":{"begin":406,"end":416},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T22","span":{"begin":558,"end":573},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T23","span":{"begin":692,"end":700},"obj":"http://purl.obolibrary.org/obo/GO_0007349"},{"id":"T24","span":{"begin":692,"end":710},"obj":"http://purl.obolibrary.org/obo/GO_0009987"},{"id":"T25","span":{"begin":765,"end":780},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A., Liu, P., Spitaler, M., Olson, E.N., McKinsey, T.A., Cantrell, D.A. and Scharenberg, A.M. (2006) Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol. Cell Biol. 26, 1569–1577]. We now show that PKDs are also required to regulate HSP27 phosphorylation in DT40 B-cells. However, in contrast to previous observations in other cell types, PKD enzymes do not regulate basic cellular processes such as proliferation or survival responses, nor NFκB transcriptional activity downstream of the B cell antigen receptor. Thus, PKDs have a selective role in DT40 B-cell biology.\n"}

{"project":"GO-CC","denotations":[{"id":"T400","span":{"begin":229,"end":234},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T401","span":{"begin":584,"end":589},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T402","span":{"begin":646,"end":650},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T403","span":{"begin":810,"end":814},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T404","span":{"begin":876,"end":880},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T405","span":{"begin":692,"end":710},"obj":"http://purl.obolibrary.org/obo/GO_0042995"}],"text":"To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A., Liu, P., Spitaler, M., Olson, E.N., McKinsey, T.A., Cantrell, D.A. and Scharenberg, A.M. (2006) Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol. Cell Biol. 26, 1569–1577]. We now show that PKDs are also required to regulate HSP27 phosphorylation in DT40 B-cells. However, in contrast to previous observations in other cell types, PKD enzymes do not regulate basic cellular processes such as proliferation or survival responses, nor NFκB transcriptional activity downstream of the B cell antigen receptor. Thus, PKDs have a selective role in DT40 B-cell biology.\n"}

{"project":"sentences","denotations":[{"id":"T17","span":{"begin":468,"end":499},"obj":"Sentence"},{"id":"T15","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"T16","span":{"begin":117,"end":467},"obj":"Sentence"},{"id":"T18","span":{"begin":500,"end":590},"obj":"Sentence"},{"id":"T19","span":{"begin":591,"end":832},"obj":"Sentence"},{"id":"T20","span":{"begin":833,"end":889},"obj":"Sentence"},{"id":"T3","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"T4","span":{"begin":117,"end":467},"obj":"Sentence"},{"id":"T5","span":{"begin":468,"end":472},"obj":"Sentence"},{"id":"T6","span":{"begin":473,"end":483},"obj":"Sentence"},{"id":"T7","span":{"begin":484,"end":499},"obj":"Sentence"},{"id":"T8","span":{"begin":500,"end":590},"obj":"Sentence"},{"id":"T9","span":{"begin":591,"end":832},"obj":"Sentence"},{"id":"T10","span":{"begin":833,"end":889},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A., Liu, P., Spitaler, M., Olson, E.N., McKinsey, T.A., Cantrell, D.A. and Scharenberg, A.M. (2006) Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol. Cell Biol. 26, 1569–1577]. We now show that PKDs are also required to regulate HSP27 phosphorylation in DT40 B-cells. However, in contrast to previous observations in other cell types, PKD enzymes do not regulate basic cellular processes such as proliferation or survival responses, nor NFκB transcriptional activity downstream of the B cell antigen receptor. Thus, PKDs have a selective role in DT40 B-cell biology.\n"}

{"project":"events-check-again","denotations":[{"id":"T425","span":{"begin":531,"end":539},"obj":"Positive_regulation"},{"id":"T426","span":{"begin":543,"end":551},"obj":"Regulation"},{"id":"T427","span":{"begin":552,"end":557},"obj":"Protein"},{"id":"T428","span":{"begin":558,"end":573},"obj":"Phosphorylation"}],"relations":[{"id":"R410","pred":"themeOf","subj":"T426","obj":"T425"},{"id":"R411","pred":"themeOf","subj":"T427","obj":"T428"},{"id":"R412","pred":"themeOf","subj":"T428","obj":"T426"}],"text":"To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A., Liu, P., Spitaler, M., Olson, E.N., McKinsey, T.A., Cantrell, D.A. and Scharenberg, A.M. (2006) Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol. Cell Biol. 26, 1569–1577]. We now show that PKDs are also required to regulate HSP27 phosphorylation in DT40 B-cells. However, in contrast to previous observations in other cell types, PKD enzymes do not regulate basic cellular processes such as proliferation or survival responses, nor NFκB transcriptional activity downstream of the B cell antigen receptor. Thus, PKDs have a selective role in DT40 B-cell biology.\n"}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T432","span":{"begin":33,"end":49},"obj":"Protein"},{"id":"T433","span":{"begin":51,"end":54},"obj":"Protein"},{"id":"T434","span":{"begin":79,"end":82},"obj":"Protein"},{"id":"T435","span":{"begin":147,"end":151},"obj":"Protein"},{"id":"T436","span":{"begin":189,"end":218},"obj":"Protein"},{"id":"T437","span":{"begin":367,"end":398},"obj":"Protein"},{"id":"T438","span":{"begin":420,"end":449},"obj":"Protein"},{"id":"T439","span":{"begin":406,"end":416},"obj":"Regulation"},{"id":"T440","span":{"begin":517,"end":521},"obj":"Protein"},{"id":"T441","span":{"begin":552,"end":557},"obj":"Protein"},{"id":"T442","span":{"begin":558,"end":573},"obj":"Phosphorylation"},{"id":"T443","span":{"begin":543,"end":551},"obj":"Regulation"},{"id":"T444","span":{"begin":531,"end":539},"obj":"Positive_regulation"},{"id":"T445","span":{"begin":658,"end":669},"obj":"Protein"},{"id":"T446","span":{"begin":760,"end":764},"obj":"Protein"},{"id":"T447","span":{"begin":808,"end":831},"obj":"Protein"},{"id":"T448","span":{"begin":677,"end":685},"obj":"Regulation"},{"id":"T449","span":{"begin":839,"end":843},"obj":"Protein"}],"relations":[{"id":"R363","pred":"themeOf","subj":"T438","obj":"T439"},{"id":"R364","pred":"causeOf","subj":"T440","obj":"T443"},{"id":"R365","pred":"causeOf","subj":"T440","obj":"T444"},{"id":"R366","pred":"themeOf","subj":"T441","obj":"T442"},{"id":"R367","pred":"themeOf","subj":"T442","obj":"T443"},{"id":"R368","pred":"themeOf","subj":"T443","obj":"T444"},{"id":"R369","pred":"causeOf","subj":"T445","obj":"T448"},{"id":"R370","pred":"themeOf","subj":"T447","obj":"T448"}],"text":"To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A., Liu, P., Spitaler, M., Olson, E.N., McKinsey, T.A., Cantrell, D.A. and Scharenberg, A.M. (2006) Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol. Cell Biol. 26, 1569–1577]. We now show that PKDs are also required to regulate HSP27 phosphorylation in DT40 B-cells. However, in contrast to previous observations in other cell types, PKD enzymes do not regulate basic cellular processes such as proliferation or survival responses, nor NFκB transcriptional activity downstream of the B cell antigen receptor. Thus, PKDs have a selective role in DT40 B-cell biology.\n"}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T10","span":{"begin":531,"end":539},"obj":"Positive_regulation"},{"id":"T11","span":{"begin":543,"end":551},"obj":"Regulation"},{"id":"T12","span":{"begin":552,"end":557},"obj":"Protein"},{"id":"T13","span":{"begin":558,"end":573},"obj":"Phosphorylation"}],"relations":[{"id":"R371","pred":"themeOf","subj":"T11","obj":"T10"},{"id":"R372","pred":"themeOf","subj":"T12","obj":"T13"},{"id":"R373","pred":"themeOf","subj":"T13","obj":"T11"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A., Liu, P., Spitaler, M., Olson, E.N., McKinsey, T.A., Cantrell, D.A. and Scharenberg, A.M. (2006) Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol. Cell Biol. 26, 1569–1577]. We now show that PKDs are also required to regulate HSP27 phosphorylation in DT40 B-cells. However, in contrast to previous observations in other cell types, PKD enzymes do not regulate basic cellular processes such as proliferation or survival responses, nor NFκB transcriptional activity downstream of the B cell antigen receptor. Thus, PKDs have a selective role in DT40 B-cell biology.\n"}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T204","span":{"begin":552,"end":557},"obj":"P04792"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A., Liu, P., Spitaler, M., Olson, E.N., McKinsey, T.A., Cantrell, D.A. and Scharenberg, A.M. (2006) Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol. Cell Biol. 26, 1569–1577]. We now show that PKDs are also required to regulate HSP27 phosphorylation in DT40 B-cells. However, in contrast to previous observations in other cell types, PKD enzymes do not regulate basic cellular processes such as proliferation or survival responses, nor NFκB transcriptional activity downstream of the B cell antigen receptor. Thus, PKDs have a selective role in DT40 B-cell biology.\n"}

{"project":"test2","denotations":[{"id":"T5","span":{"begin":531,"end":539},"obj":"Positive_regulation"},{"id":"T6","span":{"begin":543,"end":551},"obj":"Regulation"},{"id":"T7","span":{"begin":552,"end":557},"obj":"Protein"},{"id":"T8","span":{"begin":558,"end":573},"obj":"Phosphorylation"}],"relations":[{"id":"R4","pred":"themeOf","subj":"T6","obj":"T5"},{"id":"R5","pred":"themeOf","subj":"T7","obj":"T8"},{"id":"R6","pred":"themeOf","subj":"T8","obj":"T6"}],"text":"To investigate the importance of protein kinase D (PKD) enzymes we generated a PKD-null DT40 B-lymphocyte cell line. Previously we have shown that PKDs have an essential role in regulating class II histone deacetylases in DT40 B-cells [Matthews, S.A., Liu, P., Spitaler, M., Olson, E.N., McKinsey, T.A., Cantrell, D.A. and Scharenberg, A.M. (2006) Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol. Cell Biol. 26, 1569–1577]. We now show that PKDs are also required to regulate HSP27 phosphorylation in DT40 B-cells. However, in contrast to previous observations in other cell types, PKD enzymes do not regulate basic cellular processes such as proliferation or survival responses, nor NFκB transcriptional activity downstream of the B cell antigen receptor. Thus, PKDs have a selective role in DT40 B-cell biology.\n"}