PMC:1942070 / 10399-10702 JSONTXT

{"project":"pmc-enju-pas","denotations":[{"id":"T5273","span":{"begin":0,"end":7},"obj":"RB"},{"id":"T5274","span":{"begin":7,"end":8},"obj":"-COMMA-"},{"id":"T5275","span":{"begin":9,"end":20},"obj":"JJ"},{"id":"T5276","span":{"begin":21,"end":24},"obj":"NN"},{"id":"T5277","span":{"begin":25,"end":40},"obj":"NN"},{"id":"T5278","span":{"begin":41,"end":44},"obj":"VB"},{"id":"T5279","span":{"begin":45,"end":49},"obj":"RB"},{"id":"T5280","span":{"begin":50,"end":57},"obj":"VB"},{"id":"T5281","span":{"begin":58,"end":60},"obj":"IN"},{"id":"T5282","span":{"begin":61,"end":81},"obj":"JJ"},{"id":"T5283","span":{"begin":82,"end":83},"obj":"NN"},{"id":"T5284","span":{"begin":84,"end":89},"obj":"NN"},{"id":"T5285","span":{"begin":90,"end":91},"obj":"-LRB-"},{"id":"T5286","span":{"begin":91,"end":95},"obj":"NN"},{"id":"T5287","span":{"begin":96,"end":99},"obj":"RB"},{"id":"T5288","span":{"begin":100,"end":105},"obj":"VB"},{"id":"T5289","span":{"begin":105,"end":106},"obj":"-RRB-"},{"id":"T5290","span":{"begin":107,"end":117},"obj":"VB"},{"id":"T5291","span":{"begin":118,"end":122},"obj":"IN"},{"id":"T5292","span":{"begin":123,"end":130},"obj":"VB"},{"id":"T5293","span":{"begin":131,"end":134},"obj":"NN"},{"id":"T5294","span":{"begin":135,"end":141},"obj":"NN"},{"id":"T5295","span":{"begin":142,"end":144},"obj":"IN"},{"id":"T5296","span":{"begin":145,"end":148},"obj":"DT"},{"id":"T5297","span":{"begin":149,"end":156},"obj":"NN"},{"id":"T5298","span":{"begin":157,"end":159},"obj":"IN"},{"id":"T5299","span":{"begin":160,"end":169},"obj":"NN"},{"id":"T5300","span":{"begin":170,"end":171},"obj":"-LRB-"},{"id":"T5301","span":{"begin":171,"end":174},"obj":"CC"},{"id":"T5302","span":{"begin":175,"end":195},"obj":"JJ"},{"id":"T5303","span":{"begin":195,"end":196},"obj":"-RRB-"},{"id":"T5304","span":{"begin":197,"end":198},"obj":"NN"},{"id":"T5305","span":{"begin":199,"end":204},"obj":"NN"},{"id":"T5306","span":{"begin":205,"end":208},"obj":"MD"},{"id":"T5307","span":{"begin":209,"end":215},"obj":"PRP"},{"id":"T5308","span":{"begin":216,"end":222},"obj":"VB"},{"id":"T5309","span":{"begin":223,"end":225},"obj":"IN"},{"id":"T5310","span":{"begin":226,"end":229},"obj":"DT"},{"id":"T5311","span":{"begin":230,"end":238},"obj":"NN"},{"id":"T5312","span":{"begin":239,"end":241},"obj":"IN"},{"id":"T5313","span":{"begin":242,"end":252},"obj":"NN"},{"id":"T5314","span":{"begin":253,"end":255},"obj":"IN"},{"id":"T5315","span":{"begin":256,"end":260},"obj":"DT"},{"id":"T5316","span":{"begin":261,"end":269},"obj":"JJ"},{"id":"T5317","span":{"begin":270,"end":283},"obj":"JJ"},{"id":"T5318","span":{"begin":284,"end":294},"obj":"NN"},{"id":"T5319","span":{"begin":295,"end":302},"obj":"NN"}],"relations":[{"id":"R4176","pred":"arg1Of","subj":"T5277","obj":"T5275"},{"id":"R4177","pred":"arg1Of","subj":"T5277","obj":"T5276"},{"id":"R4178","pred":"arg1Of","subj":"T5277","obj":"T5278"},{"id":"R4179","pred":"arg2Of","subj":"T5277","obj":"T5280"},{"id":"R4180","pred":"arg1Of","subj":"T5280","obj":"T5273"},{"id":"R4181","pred":"arg1Of","subj":"T5280","obj":"T5274"},{"id":"R4182","pred":"arg2Of","subj":"T5280","obj":"T5278"},{"id":"R4183","pred":"arg1Of","subj":"T5280","obj":"T5279"},{"id":"R4184","pred":"arg1Of","subj":"T5280","obj":"T5281"},{"id":"R4185","pred":"modOf","subj":"T5280","obj":"T5290"},{"id":"R4186","pred":"arg2Of","subj":"T5284","obj":"T5281"},{"id":"R4187","pred":"arg1Of","subj":"T5284","obj":"T5282"},{"id":"R4188","pred":"arg1Of","subj":"T5284","obj":"T5283"},{"id":"R4189","pred":"arg1Of","subj":"T5284","obj":"T5285"},{"id":"R4190","pred":"arg2Of","subj":"T5286","obj":"T5285"},{"id":"R4191","pred":"arg2Of","subj":"T5286","obj":"T5288"},{"id":"R4192","pred":"arg1Of","subj":"T5288","obj":"T5287"},{"id":"R4193","pred":"arg3Of","subj":"T5289","obj":"T5285"},{"id":"R4194","pred":"arg2Of","subj":"T5294","obj":"T5292"},{"id":"R4195","pred":"arg1Of","subj":"T5294","obj":"T5293"},{"id":"R4196","pred":"arg1Of","subj":"T5294","obj":"T5295"},{"id":"R4197","pred":"arg1Of","subj":"T5294","obj":"T5306"},{"id":"R4198","pred":"arg1Of","subj":"T5294","obj":"T5308"},{"id":"R4199","pred":"arg2Of","subj":"T5297","obj":"T5295"},{"id":"R4200","pred":"arg1Of","subj":"T5297","obj":"T5296"},{"id":"R4201","pred":"arg1Of","subj":"T5297","obj":"T5298"},{"id":"R4202","pred":"arg1Of","subj":"T5299","obj":"T5300"},{"id":"R4203","pred":"arg2Of","subj":"T5302","obj":"T5300"},{"id":"R4204","pred":"arg1Of","subj":"T5302","obj":"T5301"},{"id":"R4205","pred":"arg3Of","subj":"T5303","obj":"T5300"},{"id":"R4206","pred":"arg2Of","subj":"T5305","obj":"T5298"},{"id":"R4207","pred":"arg1Of","subj":"T5305","obj":"T5299"},{"id":"R4208","pred":"arg1Of","subj":"T5305","obj":"T5304"},{"id":"R4209","pred":"arg2Of","subj":"T5308","obj":"T5290"},{"id":"R4210","pred":"arg1Of","subj":"T5308","obj":"T5291"},{"id":"R4211","pred":"arg2Of","subj":"T5308","obj":"T5306"},{"id":"R4212","pred":"arg1Of","subj":"T5308","obj":"T5307"},{"id":"R4213","pred":"arg1Of","subj":"T5308","obj":"T5309"},{"id":"R4214","pred":"arg2Of","subj":"T5311","obj":"T5309"},{"id":"R4215","pred":"arg1Of","subj":"T5311","obj":"T5310"},{"id":"R4216","pred":"arg1Of","subj":"T5311","obj":"T5312"},{"id":"R4217","pred":"arg2Of","subj":"T5313","obj":"T5312"},{"id":"R4218","pred":"arg1Of","subj":"T5313","obj":"T5314"},{"id":"R4219","pred":"arg2Of","subj":"T5319","obj":"T5314"},{"id":"R4220","pred":"arg1Of","subj":"T5319","obj":"T5315"},{"id":"R4221","pred":"arg1Of","subj":"T5319","obj":"T5316"},{"id":"R4222","pred":"arg1Of","subj":"T5319","obj":"T5317"},{"id":"R4223","pred":"arg1Of","subj":"T5319","obj":"T5318"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway."}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T6035","span":{"begin":0,"end":7},"obj":"RB"},{"id":"T6036","span":{"begin":7,"end":8},"obj":","},{"id":"T6037","span":{"begin":9,"end":20},"obj":"JJ"},{"id":"T6038","span":{"begin":21,"end":24},"obj":"NNP"},{"id":"T6039","span":{"begin":25,"end":40},"obj":"NN"},{"id":"T6040","span":{"begin":41,"end":44},"obj":"VBD"},{"id":"T6041","span":{"begin":45,"end":49},"obj":"RB"},{"id":"T6042","span":{"begin":50,"end":57},"obj":"VBN"},{"id":"T6043","span":{"begin":58,"end":60},"obj":"IN"},{"id":"T6044","span":{"begin":61,"end":67},"obj":"CD"},{"id":"T6045","span":{"begin":67,"end":68},"obj":"CD"},{"id":"T6046","span":{"begin":68,"end":69},"obj":"NN"},{"id":"T6047","span":{"begin":69,"end":70},"obj":"SYM"},{"id":"T6048","span":{"begin":70,"end":71},"obj":":"},{"id":"T6049","span":{"begin":71,"end":80},"obj":"NN"},{"id":"T6050","span":{"begin":80,"end":81},"obj":"NN"},{"id":"T6051","span":{"begin":82,"end":83},"obj":"NNP"},{"id":"T6052","span":{"begin":84,"end":89},"obj":"NNS"},{"id":"T6053","span":{"begin":90,"end":91},"obj":"-LRB-"},{"id":"T6054","span":{"begin":91,"end":95},"obj":"NNS"},{"id":"T6055","span":{"begin":96,"end":99},"obj":"RB"},{"id":"T6056","span":{"begin":100,"end":105},"obj":"VBN"},{"id":"T6057","span":{"begin":105,"end":106},"obj":"-RRB-"},{"id":"T6058","span":{"begin":107,"end":117},"obj":"VBG"},{"id":"T6059","span":{"begin":118,"end":122},"obj":"IN"},{"id":"T6060","span":{"begin":123,"end":130},"obj":"VBN"},{"id":"T6061","span":{"begin":131,"end":134},"obj":"NNP"},{"id":"T6062","span":{"begin":135,"end":141},"obj":"NNS"},{"id":"T6063","span":{"begin":142,"end":144},"obj":"IN"},{"id":"T6064","span":{"begin":145,"end":148},"obj":"DT"},{"id":"T6065","span":{"begin":149,"end":156},"obj":"NN"},{"id":"T6066","span":{"begin":157,"end":159},"obj":"IN"},{"id":"T6067","span":{"begin":160,"end":166},"obj":"CD"},{"id":"T6068","span":{"begin":166,"end":167},"obj":"CD"},{"id":"T6069","span":{"begin":167,"end":168},"obj":"NN"},{"id":"T6070","span":{"begin":168,"end":169},"obj":"NN"},{"id":"T6071","span":{"begin":170,"end":171},"obj":"-LRB-"},{"id":"T6072","span":{"begin":171,"end":174},"obj":"CC"},{"id":"T6073","span":{"begin":175,"end":181},"obj":"NNP"},{"id":"T6074","span":{"begin":181,"end":182},"obj":"VBD"},{"id":"T6075","span":{"begin":182,"end":183},"obj":"CD"},{"id":"T6076","span":{"begin":183,"end":184},"obj":"SYM"},{"id":"T6077","span":{"begin":184,"end":185},"obj":":"},{"id":"T6078","span":{"begin":185,"end":194},"obj":"NN"},{"id":"T6079","span":{"begin":194,"end":195},"obj":"NN"},{"id":"T6080","span":{"begin":195,"end":196},"obj":"-RRB-"},{"id":"T6081","span":{"begin":197,"end":198},"obj":"NNP"},{"id":"T6082","span":{"begin":199,"end":204},"obj":"NNS"},{"id":"T6083","span":{"begin":205,"end":208},"obj":"MD"},{"id":"T6084","span":{"begin":209,"end":215},"obj":"PRP"},{"id":"T6085","span":{"begin":216,"end":222},"obj":"VB"},{"id":"T6086","span":{"begin":223,"end":225},"obj":"IN"},{"id":"T6087","span":{"begin":226,"end":229},"obj":"DT"},{"id":"T6088","span":{"begin":230,"end":238},"obj":"NN"},{"id":"T6089","span":{"begin":239,"end":241},"obj":"IN"},{"id":"T6090","span":{"begin":242,"end":252},"obj":"NN"},{"id":"T6091","span":{"begin":253,"end":255},"obj":"IN"},{"id":"T6092","span":{"begin":256,"end":260},"obj":"DT"},{"id":"T6093","span":{"begin":261,"end":269},"obj":"JJ"},{"id":"T6094","span":{"begin":270,"end":283},"obj":"JJ"},{"id":"T6095","span":{"begin":284,"end":294},"obj":"NN"},{"id":"T6096","span":{"begin":295,"end":302},"obj":"NN"},{"id":"T6097","span":{"begin":302,"end":303},"obj":"."}],"relations":[{"id":"R4888","pred":"advmod","subj":"T6035","obj":"T6042"},{"id":"R4889","pred":"punct","subj":"T6036","obj":"T6042"},{"id":"R4890","pred":"amod","subj":"T6037","obj":"T6039"},{"id":"R4891","pred":"compound","subj":"T6038","obj":"T6039"},{"id":"R4892","pred":"nsubjpass","subj":"T6039","obj":"T6042"},{"id":"R4893","pred":"auxpass","subj":"T6040","obj":"T6042"},{"id":"R4894","pred":"advmod","subj":"T6041","obj":"T6042"},{"id":"R4895","pred":"ROOT","subj":"T6042","obj":"T6042"},{"id":"R4896","pred":"prep","subj":"T6043","obj":"T6042"},{"id":"R4897","pred":"nummod","subj":"T6044","obj":"T6052"},{"id":"R4898","pred":"nummod","subj":"T6045","obj":"T6046"},{"id":"R4899","pred":"compound","subj":"T6046","obj":"T6052"},{"id":"R4900","pred":"punct","subj":"T6047","obj":"T6049"},{"id":"R4901","pred":"punct","subj":"T6048","obj":"T6049"},{"id":"R4902","pred":"compound","subj":"T6049","obj":"T6052"},{"id":"R4903","pred":"compound","subj":"T6050","obj":"T6052"},{"id":"R4904","pred":"compound","subj":"T6051","obj":"T6052"},{"id":"R4905","pred":"pobj","subj":"T6052","obj":"T6043"},{"id":"R4906","pred":"punct","subj":"T6053","obj":"T6052"},{"id":"R4907","pred":"ROOT","subj":"T6054","obj":"T6054"},{"id":"R4908","pred":"neg","subj":"T6055","obj":"T6056"},{"id":"R4909","pred":"acl","subj":"T6056","obj":"T6054"},{"id":"R4910","pred":"punct","subj":"T6057","obj":"T6054"},{"id":"R4911","pred":"advcl","subj":"T6058","obj":"T6042"},{"id":"R4912","pred":"mark","subj":"T6059","obj":"T6074"},{"id":"R4913","pred":"amod","subj":"T6060","obj":"T6062"},{"id":"R4914","pred":"compound","subj":"T6061","obj":"T6062"},{"id":"R4915","pred":"nsubj","subj":"T6062","obj":"T6074"},{"id":"R4916","pred":"prep","subj":"T6063","obj":"T6062"},{"id":"R4917","pred":"det","subj":"T6064","obj":"T6065"},{"id":"R4918","pred":"pobj","subj":"T6065","obj":"T6063"},{"id":"R4919","pred":"prep","subj":"T6066","obj":"T6065"},{"id":"R4920","pred":"nummod","subj":"T6067","obj":"T6070"},{"id":"R4921","pred":"nummod","subj":"T6068","obj":"T6070"},{"id":"R4922","pred":"compound","subj":"T6069","obj":"T6070"},{"id":"R4923","pred":"pobj","subj":"T6070","obj":"T6066"},{"id":"R4924","pred":"punct","subj":"T6071","obj":"T6070"},{"id":"R4925","pred":"cc","subj":"T6072","obj":"T6070"},{"id":"R4926","pred":"nsubj","subj":"T6073","obj":"T6074"},{"id":"R4927","pred":"ccomp","subj":"T6074","obj":"T6058"},{"id":"R4928","pred":"nummod","subj":"T6075","obj":"T6079"},{"id":"R4929","pred":"punct","subj":"T6076","obj":"T6078"},{"id":"R4930","pred":"punct","subj":"T6077","obj":"T6078"},{"id":"R4939","pred":"prep","subj":"T6086","obj":"T6085"},{"id":"R4940","pred":"det","subj":"T6087","obj":"T6088"},{"id":"R4941","pred":"pobj","subj":"T6088","obj":"T6086"},{"id":"R4942","pred":"prep","subj":"T6089","obj":"T6088"},{"id":"R4943","pred":"pobj","subj":"T6090","obj":"T6089"},{"id":"R4944","pred":"prep","subj":"T6091","obj":"T6090"},{"id":"R4945","pred":"det","subj":"T6092","obj":"T6096"},{"id":"R4946","pred":"amod","subj":"T6093","obj":"T6096"},{"id":"R4947","pred":"amod","subj":"T6094","obj":"T6096"},{"id":"R4948","pred":"compound","subj":"T6095","obj":"T6096"},{"id":"R4949","pred":"pobj","subj":"T6096","obj":"T6091"},{"id":"R4950","pred":"punct","subj":"T6097","obj":"T6085"},{"id":"R4931","pred":"compound","subj":"T6078","obj":"T6079"},{"id":"R4932","pred":"appos","subj":"T6079","obj":"T6074"},{"id":"R4933","pred":"punct","subj":"T6080","obj":"T6074"},{"id":"R4934","pred":"amod","subj":"T6081","obj":"T6082"},{"id":"R4935","pred":"nsubj","subj":"T6082","obj":"T6085"},{"id":"R4936","pred":"aux","subj":"T6083","obj":"T6085"},{"id":"R4937","pred":"nsubj","subj":"T6084","obj":"T6085"},{"id":"R4938","pred":"ROOT","subj":"T6085","obj":"T6085"}],"text":"However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway."}

{"project":"GO-BP","denotations":[{"id":"T6522","span":{"begin":284,"end":294},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T6531","span":{"begin":25,"end":40},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T6544","span":{"begin":270,"end":302},"obj":"http://purl.obolibrary.org/obo/GO_0030522"},{"id":"T6545","span":{"begin":270,"end":302},"obj":"http://purl.obolibrary.org/obo/GO_0035556"},{"id":"T6546","span":{"begin":270,"end":302},"obj":"http://purl.obolibrary.org/obo/GO_1902532"},{"id":"T6547","span":{"begin":270,"end":302},"obj":"http://purl.obolibrary.org/obo/GO_1902531"},{"id":"T6548","span":{"begin":270,"end":302},"obj":"http://purl.obolibrary.org/obo/GO_1902533"}],"text":"However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway."}

{"project":"GO-CC","denotations":[{"id":"T6565","span":{"begin":84,"end":89},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T6566","span":{"begin":199,"end":204},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T6576","span":{"begin":270,"end":283},"obj":"http://purl.obolibrary.org/obo/GO_0005622"}],"text":"However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway."}

{"project":"sentences","denotations":[{"id":"T5016","span":{"begin":0,"end":303},"obj":"Sentence"},{"id":"T71","span":{"begin":0,"end":303},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway."}

{"project":"events-check-again","denotations":[{"id":"T6942","span":{"begin":165,"end":166},"obj":"Protein"},{"id":"T6943","span":{"begin":175,"end":179},"obj":"Protein"},{"id":"T6938","span":{"begin":61,"end":65},"obj":"Protein"},{"id":"T6939","span":{"begin":66,"end":67},"obj":"Protein"},{"id":"T6940","span":{"begin":76,"end":80},"obj":"Protein"},{"id":"T6941","span":{"begin":160,"end":164},"obj":"Protein"},{"id":"T6944","span":{"begin":180,"end":181},"obj":"Protein"},{"id":"T6945","span":{"begin":190,"end":194},"obj":"Protein"}],"text":"However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway."}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T4975","span":{"begin":61,"end":65},"obj":"Protein"},{"id":"T4976","span":{"begin":66,"end":67},"obj":"Protein"},{"id":"T4977","span":{"begin":76,"end":80},"obj":"Protein"},{"id":"T4978","span":{"begin":160,"end":164},"obj":"Protein"},{"id":"T4979","span":{"begin":165,"end":166},"obj":"Protein"},{"id":"T4980","span":{"begin":175,"end":179},"obj":"Protein"},{"id":"T4981","span":{"begin":180,"end":181},"obj":"Protein"},{"id":"T4982","span":{"begin":190,"end":194},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T5723","span":{"begin":9,"end":12},"obj":"P11274"},{"id":"T5724","span":{"begin":61,"end":65},"obj":"P98161"},{"id":"T5725","span":{"begin":76,"end":80},"obj":"Q99853"},{"id":"T5726","span":{"begin":131,"end":134},"obj":"P11274"},{"id":"T5727","span":{"begin":160,"end":164},"obj":"P98161"},{"id":"T5728","span":{"begin":175,"end":179},"obj":"P98161"},{"id":"T5729","span":{"begin":190,"end":194},"obj":"Q99853"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway."}

{"project":"test2","denotations":[{"id":"T4909","span":{"begin":13,"end":20},"obj":"Positive_regulation"},{"id":"T4910","span":{"begin":25,"end":40},"obj":"Phosphorylation"},{"id":"T4911","span":{"begin":50,"end":57},"obj":"Negative_regulation"},{"id":"T4912","span":{"begin":61,"end":65},"obj":"Protein"},{"id":"T4913","span":{"begin":66,"end":67},"obj":"Protein"},{"id":"T4914","span":{"begin":76,"end":80},"obj":"Protein"},{"id":"T4915","span":{"begin":160,"end":164},"obj":"Protein"},{"id":"T4916","span":{"begin":165,"end":166},"obj":"Protein"},{"id":"T4917","span":{"begin":175,"end":179},"obj":"Protein"},{"id":"T4918","span":{"begin":180,"end":181},"obj":"Protein"},{"id":"T4919","span":{"begin":190,"end":194},"obj":"Protein"}],"relations":[{"id":"R3898","pred":"themeOf","subj":"T4909","obj":"T4911"},{"id":"R3899","pred":"themeOf","subj":"T4910","obj":"T4909"},{"id":"R3900","pred":"themeOf","subj":"T4910","obj":"T4911"}],"text":"However, BCR-induced Erk phosphorylation was also reduced in PKD1/3−/−-Flag-PKD3+ B cells (data not shown) suggesting that reduced BCR levels on the surface of PKD1/3−/− (and PKD1/3−/−-Flag-PKD3+) B cells may itself impact on the strength of activation of this specific intracellular signalling pathway."}