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PMC:1941754 / 13782-15513 JSON TXT

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craft-sa-dev

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of Mutant Gonads\nAll are hematoxylin/eosin-stained paraffin sections. Testes are from 6-wk-old males, except as indicated below.\n(A) Wild-type 25-d-old ovary.\n(B) Trip13Gt /Gt 25-d-old ovary, showing dysgenesis from an absence of oocytes.\n(C) Trip13Gt/+ 2-d-old control ovary. Arrows point to oocytes in newly forming follicles.\n(D) Trip13Gt/Gt 2-d-old ovary, dysgenic due to lack of oocytes. Magnification is the same as its littermate in “C.”\n(E) Wild-type testis.\n(F) Trip13Gt/Gt testis with uniform pachytene arrest.\n(G) Trip13Gt/Gt 3-mo-old testis with some postmeiotic spermatids (arrows).\n(H) Spo11−/- testis. A tubule with spermatocytes at leptotene/zygotene transition is labeled ZP, and tubules with apoptotic spermatocytes are marked with an asterisk. The specimen was taken from a littermate of that in (I).\n(I) Spo11 −/− Trip13Gt/Gt testis. Labeling is the same as in (H). The inset contains a tubule with leptotene-zygotene spermatocytes.\n(J) Mei1 −/− Trip13Gt/+ testis. The specimen was taken from a littermate of that in (K).\n(K) Mei1 −/− Trip13Gt/Gt testis.\n(L) Rec8Mei8/Rec8Mei8 Trip13Gt/+ testis. The Rec8Mei8 allele was described [39]. The specimen was taken from a littermate of that in (M).\n(M) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt testis.\n(N) Dmc1 −/− Trip13Gt/Gt testis.\n(O) Spo11 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (P).\n(P) Spo11 −/− Trip13Gt/Gt 25-d-old ovary.\n(Q) Mei1 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (R).\n(R) Mei1 −/− Trip13Gt/Gt 25-d-old ovary.\n(S) Rec8Mei8/Rec8Mei8 Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (T).\n(T) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt 25-d-old ovary."}

craft-ca-core-dev

{"project":"craft-ca-core-dev","denotations":[{"id":"T10876","span":{"begin":20,"end":26},"obj":"UBERON:0000991"},{"id":"T10877","span":{"begin":35,"end":46},"obj":"CHEBI:51686"},{"id":"T10878","span":{"begin":80,"end":86},"obj":"UBERON:0000473"},{"id":"T10879","span":{"begin":162,"end":167},"obj":"UBERON:0000992"},{"id":"T10880","span":{"begin":173,"end":179},"obj":"PR:000016672"},{"id":"T10881","span":{"begin":195,"end":200},"obj":"UBERON:0000992"},{"id":"T10882","span":{"begin":240,"end":247},"obj":"CL:0000023"},{"id":"T10883","span":{"begin":253,"end":259},"obj":"PR:000016672"},{"id":"T10884","span":{"begin":280,"end":285},"obj":"UBERON:0000992"},{"id":"T10885","span":{"begin":303,"end":310},"obj":"CL:0000023"},{"id":"T10886","span":{"begin":343,"end":349},"obj":"PR:000016672"},{"id":"T10887","span":{"begin":363,"end":368},"obj":"UBERON:0000992"},{"id":"T10888","span":{"begin":394,"end":401},"obj":"CL:0000023"},{"id":"T10889","span":{"begin":469,"end":475},"obj":"UBERON:0000473"},{"id":"T10890","span":{"begin":481,"end":487},"obj":"PR:000016672"},{"id":"T10891","span":{"begin":493,"end":499},"obj":"UBERON:0000473"},{"id":"T10892","span":{"begin":513,"end":522},"obj":"GO:0000239"},{"id":"T10893","span":{"begin":535,"end":541},"obj":"PR:000016672"},{"id":"T10894","span":{"begin":556,"end":562},"obj":"UBERON:0000473"},{"id":"T10895","span":{"begin":577,"end":584},"obj":"GO:0007126"},{"id":"T10896","span":{"begin":585,"end":595},"obj":"CL:0000018"},{"id":"T10897","span":{"begin":610,"end":615},"obj":"PR:000015553"},{"id":"T10898","span":{"begin":619,"end":625},"obj":"UBERON:0000473"},{"id":"T10899","span":{"begin":629,"end":635},"obj":"UBERON:0000025"},{"id":"T10900","span":{"begin":641,"end":654},"obj":"CL:0000017"},{"id":"T10901","span":{"begin":658,"end":667},"obj":"GO:0000237"},{"id":"T10902","span":{"begin":668,"end":676},"obj":"GO:0000238"},{"id":"T10903","span":{"begin":707,"end":714},"obj":"UBERON:0000025"},{"id":"T10904","span":{"begin":730,"end":743},"obj":"CL:0000017"},{"id":"T10905","span":{"begin":834,"end":839},"obj":"PR:000015553"},{"id":"T10906","span":{"begin":844,"end":850},"obj":"PR:000016672"},{"id":"T10907","span":{"begin":856,"end":862},"obj":"UBERON:0000473"},{"id":"T10908","span":{"begin":917,"end":923},"obj":"UBERON:0000025"},{"id":"T10909","span":{"begin":929,"end":938},"obj":"GO:0000237"},{"id":"T10910","span":{"begin":939,"end":947},"obj":"GO:0000238"},{"id":"T10911","span":{"begin":948,"end":961},"obj":"CL:0000017"},{"id":"T10912","span":{"begin":967,"end":971},"obj":"PR:000031227"},{"id":"T10913","span":{"begin":976,"end":982},"obj":"PR:000016672"},{"id":"T10914","span":{"begin":987,"end":993},"obj":"UBERON:0000473"},{"id":"T10915","span":{"begin":1056,"end":1060},"obj":"PR:000031227"},{"id":"T10916","span":{"begin":1065,"end":1071},"obj":"PR:000016672"},{"id":"T10917","span":{"begin":1077,"end":1083},"obj":"UBERON:0000473"},{"id":"T10918","span":{"begin":1089,"end":1093},"obj":"PR:000013858"},{"id":"T10919","span":{"begin":1098,"end":1102},"obj":"PR:000013858"},{"id":"T10920","span":{"begin":1107,"end":1113},"obj":"PR:000016672"},{"id":"T10940","span":{"begin":1539,"end":1543},"obj":"PR:000031227"},{"id":"T10941","span":{"begin":1548,"end":1554},"obj":"PR:000016672"},{"id":"T10942","span":{"begin":1569,"end":1574},"obj":"UBERON:0000992"},{"id":"T10943","span":{"begin":1580,"end":1584},"obj":"PR:000013858"},{"id":"T10944","span":{"begin":1589,"end":1593},"obj":"PR:000013858"},{"id":"T10945","span":{"begin":1598,"end":1604},"obj":"PR:000016672"},{"id":"T10946","span":{"begin":1618,"end":1623},"obj":"UBERON:0000992"},{"id":"T10947","span":{"begin":1686,"end":1690},"obj":"PR:000013858"},{"id":"T10948","span":{"begin":1695,"end":1699},"obj":"PR:000013858"},{"id":"T10949","span":{"begin":1704,"end":1710},"obj":"PR:000016672"},{"id":"T10950","span":{"begin":1725,"end":1730},"obj":"UBERON:0000992"},{"id":"T10921","span":{"begin":1118,"end":1124},"obj":"UBERON:0000473"},{"id":"T10922","span":{"begin":1130,"end":1134},"obj":"PR:000013858"},{"id":"T10923","span":{"begin":1139,"end":1145},"obj":"SO:0001023"},{"id":"T10924","span":{"begin":1227,"end":1231},"obj":"PR:000013858"},{"id":"T10925","span":{"begin":1236,"end":1240},"obj":"PR:000013858"},{"id":"T10926","span":{"begin":1245,"end":1251},"obj":"PR:000016672"},{"id":"T10927","span":{"begin":1257,"end":1263},"obj":"UBERON:0000473"},{"id":"T10928","span":{"begin":1269,"end":1273},"obj":"PR:000006536"},{"id":"T10929","span":{"begin":1278,"end":1284},"obj":"PR:000016672"},{"id":"T10930","span":{"begin":1290,"end":1296},"obj":"UBERON:0000473"},{"id":"T10931","span":{"begin":1302,"end":1307},"obj":"PR:000015553"},{"id":"T10932","span":{"begin":1312,"end":1318},"obj":"PR:000016672"},{"id":"T10933","span":{"begin":1332,"end":1337},"obj":"UBERON:0000992"},{"id":"T10934","span":{"begin":1400,"end":1405},"obj":"PR:000015553"},{"id":"T10935","span":{"begin":1410,"end":1416},"obj":"PR:000016672"},{"id":"T10936","span":{"begin":1431,"end":1436},"obj":"UBERON:0000992"},{"id":"T10937","span":{"begin":1442,"end":1446},"obj":"PR:000031227"},{"id":"T10938","span":{"begin":1451,"end":1457},"obj":"PR:000016672"},{"id":"T10939","span":{"begin":1471,"end":1476},"obj":"UBERON:0000992"}],"text":"Histology of Mutant Gonads\nAll are hematoxylin/eosin-stained paraffin sections. Testes are from 6-wk-old males, except as indicated below.\n(A) Wild-type 25-d-old ovary.\n(B) Trip13Gt /Gt 25-d-old ovary, showing dysgenesis from an absence of oocytes.\n(C) Trip13Gt/+ 2-d-old control ovary. Arrows point to oocytes in newly forming follicles.\n(D) Trip13Gt/Gt 2-d-old ovary, dysgenic due to lack of oocytes. Magnification is the same as its littermate in “C.”\n(E) Wild-type testis.\n(F) Trip13Gt/Gt testis with uniform pachytene arrest.\n(G) Trip13Gt/Gt 3-mo-old testis with some postmeiotic spermatids (arrows).\n(H) Spo11−/- testis. A tubule with spermatocytes at leptotene/zygotene transition is labeled ZP, and tubules with apoptotic spermatocytes are marked with an asterisk. The specimen was taken from a littermate of that in (I).\n(I) Spo11 −/− Trip13Gt/Gt testis. Labeling is the same as in (H). The inset contains a tubule with leptotene-zygotene spermatocytes.\n(J) Mei1 −/− Trip13Gt/+ testis. The specimen was taken from a littermate of that in (K).\n(K) Mei1 −/− Trip13Gt/Gt testis.\n(L) Rec8Mei8/Rec8Mei8 Trip13Gt/+ testis. The Rec8Mei8 allele was described [39]. The specimen was taken from a littermate of that in (M).\n(M) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt testis.\n(N) Dmc1 −/− Trip13Gt/Gt testis.\n(O) Spo11 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (P).\n(P) Spo11 −/− Trip13Gt/Gt 25-d-old ovary.\n(Q) Mei1 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (R).\n(R) Mei1 −/− Trip13Gt/Gt 25-d-old ovary.\n(S) Rec8Mei8/Rec8Mei8 Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (T).\n(T) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt 25-d-old ovary."}

2_test

{"project":"2_test","denotations":[{"id":"17696610-15515002-85497896","span":{"begin":1161,"end":1163},"obj":"15515002"},{"id":"T34992","span":{"begin":1161,"end":1163},"obj":"15515002"}],"text":"Histology of Mutant Gonads\nAll are hematoxylin/eosin-stained paraffin sections. Testes are from 6-wk-old males, except as indicated below.\n(A) Wild-type 25-d-old ovary.\n(B) Trip13Gt /Gt 25-d-old ovary, showing dysgenesis from an absence of oocytes.\n(C) Trip13Gt/+ 2-d-old control ovary. Arrows point to oocytes in newly forming follicles.\n(D) Trip13Gt/Gt 2-d-old ovary, dysgenic due to lack of oocytes. Magnification is the same as its littermate in “C.”\n(E) Wild-type testis.\n(F) Trip13Gt/Gt testis with uniform pachytene arrest.\n(G) Trip13Gt/Gt 3-mo-old testis with some postmeiotic spermatids (arrows).\n(H) Spo11−/- testis. A tubule with spermatocytes at leptotene/zygotene transition is labeled ZP, and tubules with apoptotic spermatocytes are marked with an asterisk. The specimen was taken from a littermate of that in (I).\n(I) Spo11 −/− Trip13Gt/Gt testis. Labeling is the same as in (H). The inset contains a tubule with leptotene-zygotene spermatocytes.\n(J) Mei1 −/− Trip13Gt/+ testis. The specimen was taken from a littermate of that in (K).\n(K) Mei1 −/− Trip13Gt/Gt testis.\n(L) Rec8Mei8/Rec8Mei8 Trip13Gt/+ testis. The Rec8Mei8 allele was described [39]. The specimen was taken from a littermate of that in (M).\n(M) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt testis.\n(N) Dmc1 −/− Trip13Gt/Gt testis.\n(O) Spo11 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (P).\n(P) Spo11 −/− Trip13Gt/Gt 25-d-old ovary.\n(Q) Mei1 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (R).\n(R) Mei1 −/− Trip13Gt/Gt 25-d-old ovary.\n(S) Rec8Mei8/Rec8Mei8 Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (T).\n(T) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt 25-d-old ovary."}

craft-ca-core-ex-dev

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T10951","span":{"begin":13,"end":19},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T10952","span":{"begin":20,"end":26},"obj":"UBERON:0000991"},{"id":"T10953","span":{"begin":35,"end":46},"obj":"CHEBI:51686"},{"id":"T10954","span":{"begin":47,"end":52},"obj":"CHEBI_EXT:eosin"},{"id":"T10955","span":{"begin":80,"end":86},"obj":"UBERON:0000473"},{"id":"T10956","span":{"begin":105,"end":110},"obj":"PATO_UBERON_EXT:male_or_bearer_of_maleness"},{"id":"T10957","span":{"begin":143,"end":152},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T10958","span":{"begin":162,"end":167},"obj":"UBERON:0000992"},{"id":"T10959","span":{"begin":173,"end":179},"obj":"PR_EXT:000016672"},{"id":"T10960","span":{"begin":195,"end":200},"obj":"UBERON:0000992"},{"id":"T10961","span":{"begin":240,"end":247},"obj":"CL:0000023"},{"id":"T10962","span":{"begin":253,"end":259},"obj":"PR_EXT:000016672"},{"id":"T10963","span":{"begin":262,"end":263},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T10964","span":{"begin":280,"end":285},"obj":"UBERON:0000992"},{"id":"T10965","span":{"begin":303,"end":310},"obj":"CL:0000023"},{"id":"T10966","span":{"begin":328,"end":337},"obj":"UBERON_EXT:follicle"},{"id":"T10967","span":{"begin":343,"end":349},"obj":"PR_EXT:000016672"},{"id":"T10968","span":{"begin":363,"end":368},"obj":"UBERON:0000992"},{"id":"T10969","span":{"begin":394,"end":401},"obj":"CL:0000023"},{"id":"T10970","span":{"begin":459,"end":468},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T10971","span":{"begin":469,"end":475},"obj":"UBERON:0000473"},{"id":"T10972","span":{"begin":481,"end":487},"obj":"PR_EXT:000016672"},{"id":"T10973","span":{"begin":493,"end":499},"obj":"UBERON:0000473"},{"id":"T10974","span":{"begin":513,"end":522},"obj":"GO:0000239"},{"id":"T10975","span":{"begin":535,"end":541},"obj":"PR_EXT:000016672"},{"id":"T10976","span":{"begin":556,"end":562},"obj":"UBERON:0000473"},{"id":"T10977","span":{"begin":577,"end":584},"obj":"GO:0007126"},{"id":"T10978","span":{"begin":585,"end":595},"obj":"CL:0000018"},{"id":"T10979","span":{"begin":610,"end":615},"obj":"PR_EXT:000015553"},{"id":"T10980","span":{"begin":615,"end":616},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T10981","span":{"begin":617,"end":618},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T10982","span":{"begin":619,"end":625},"obj":"UBERON:0000473"},{"id":"T10983","span":{"begin":629,"end":635},"obj":"UBERON:0000025"},{"id":"T10984","span":{"begin":641,"end":654},"obj":"CL:0000017"},{"id":"T10985","span":{"begin":658,"end":667},"obj":"GO:0000237"},{"id":"T10986","span":{"begin":668,"end":676},"obj":"GO:0000238"},{"id":"T10987","span":{"begin":707,"end":714},"obj":"UBERON:0000025"},{"id":"T10988","span":{"begin":720,"end":729},"obj":"GO_PATO_EXT:apoptotic_process_or_quality"},{"id":"T10989","span":{"begin":730,"end":743},"obj":"CL:0000017"},{"id":"T10990","span":{"begin":834,"end":839},"obj":"PR_EXT:000015553"},{"id":"T10991","span":{"begin":840,"end":841},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T10992","span":{"begin":842,"end":843},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T10993","span":{"begin":844,"end":850},"obj":"PR_EXT:000016672"},{"id":"T10994","span":{"begin":856,"end":862},"obj":"UBERON:0000473"},{"id":"T10995","span":{"begin":917,"end":923},"obj":"UBERON:0000025"},{"id":"T10996","span":{"begin":929,"end":938},"obj":"GO:0000237"},{"id":"T10997","span":{"begin":939,"end":947},"obj":"GO:0000238"},{"id":"T10998","span":{"begin":948,"end":961},"obj":"CL:0000017"},{"id":"T10999","span":{"begin":967,"end":971},"obj":"PR_EXT:000031227"},{"id":"T11000","span":{"begin":972,"end":973},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11001","span":{"begin":974,"end":975},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11002","span":{"begin":976,"end":982},"obj":"PR_EXT:000016672"},{"id":"T11003","span":{"begin":985,"end":986},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T11004","span":{"begin":987,"end":993},"obj":"UBERON:0000473"},{"id":"T11005","span":{"begin":1056,"end":1060},"obj":"PR_EXT:000031227"},{"id":"T11006","span":{"begin":1061,"end":1062},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11007","span":{"begin":1063,"end":1064},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11008","span":{"begin":1065,"end":1071},"obj":"PR_EXT:000016672"},{"id":"T11009","span":{"begin":1077,"end":1083},"obj":"UBERON:0000473"},{"id":"T11010","span":{"begin":1089,"end":1093},"obj":"PR_EXT:000013858"},{"id":"T11011","span":{"begin":1098,"end":1102},"obj":"PR_EXT:000013858"},{"id":"T11012","span":{"begin":1107,"end":1113},"obj":"PR_EXT:000016672"},{"id":"T11013","span":{"begin":1116,"end":1117},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T11014","span":{"begin":1118,"end":1124},"obj":"UBERON:0000473"},{"id":"T11015","span":{"begin":1130,"end":1134},"obj":"PR_EXT:000013858"},{"id":"T11016","span":{"begin":1139,"end":1145},"obj":"SO_EXT:0001023"},{"id":"T11017","span":{"begin":1227,"end":1231},"obj":"PR_EXT:000013858"},{"id":"T11018","span":{"begin":1236,"end":1240},"obj":"PR_EXT:000013858"},{"id":"T11019","span":{"begin":1245,"end":1251},"obj":"PR_EXT:000016672"},{"id":"T11020","span":{"begin":1257,"end":1263},"obj":"UBERON:0000473"},{"id":"T11021","span":{"begin":1269,"end":1273},"obj":"PR_EXT:000006536"},{"id":"T11022","span":{"begin":1274,"end":1275},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11023","span":{"begin":1276,"end":1277},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11024","span":{"begin":1278,"end":1284},"obj":"PR_EXT:000016672"},{"id":"T11025","span":{"begin":1290,"end":1296},"obj":"UBERON:0000473"},{"id":"T11026","span":{"begin":1302,"end":1307},"obj":"PR_EXT:000015553"},{"id":"T11027","span":{"begin":1308,"end":1309},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11028","span":{"begin":1310,"end":1311},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11029","span":{"begin":1312,"end":1318},"obj":"PR_EXT:000016672"},{"id":"T11030","span":{"begin":1321,"end":1322},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T11031","span":{"begin":1332,"end":1337},"obj":"UBERON:0000992"},{"id":"T11032","span":{"begin":1400,"end":1405},"obj":"PR_EXT:000015553"},{"id":"T11033","span":{"begin":1406,"end":1407},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11034","span":{"begin":1408,"end":1409},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11035","span":{"begin":1410,"end":1416},"obj":"PR_EXT:000016672"},{"id":"T11036","span":{"begin":1431,"end":1436},"obj":"UBERON:0000992"},{"id":"T11037","span":{"begin":1442,"end":1446},"obj":"PR_EXT:000031227"},{"id":"T11038","span":{"begin":1447,"end":1448},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11056","span":{"begin":1725,"end":1730},"obj":"UBERON:0000992"},{"id":"T11039","span":{"begin":1449,"end":1450},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11040","span":{"begin":1451,"end":1457},"obj":"PR_EXT:000016672"},{"id":"T11041","span":{"begin":1460,"end":1461},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T11042","span":{"begin":1471,"end":1476},"obj":"UBERON:0000992"},{"id":"T11043","span":{"begin":1539,"end":1543},"obj":"PR_EXT:000031227"},{"id":"T11044","span":{"begin":1544,"end":1545},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11045","span":{"begin":1546,"end":1547},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T11046","span":{"begin":1548,"end":1554},"obj":"PR_EXT:000016672"},{"id":"T11047","span":{"begin":1569,"end":1574},"obj":"UBERON:0000992"},{"id":"T11048","span":{"begin":1580,"end":1584},"obj":"PR_EXT:000013858"},{"id":"T11049","span":{"begin":1589,"end":1593},"obj":"PR_EXT:000013858"},{"id":"T11050","span":{"begin":1598,"end":1604},"obj":"PR_EXT:000016672"},{"id":"T11051","span":{"begin":1607,"end":1608},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T11052","span":{"begin":1618,"end":1623},"obj":"UBERON:0000992"},{"id":"T11053","span":{"begin":1686,"end":1690},"obj":"PR_EXT:000013858"},{"id":"T11054","span":{"begin":1695,"end":1699},"obj":"PR_EXT:000013858"},{"id":"T11055","span":{"begin":1704,"end":1710},"obj":"PR_EXT:000016672"}],"text":"Histology of Mutant Gonads\nAll are hematoxylin/eosin-stained paraffin sections. Testes are from 6-wk-old males, except as indicated below.\n(A) Wild-type 25-d-old ovary.\n(B) Trip13Gt /Gt 25-d-old ovary, showing dysgenesis from an absence of oocytes.\n(C) Trip13Gt/+ 2-d-old control ovary. Arrows point to oocytes in newly forming follicles.\n(D) Trip13Gt/Gt 2-d-old ovary, dysgenic due to lack of oocytes. Magnification is the same as its littermate in “C.”\n(E) Wild-type testis.\n(F) Trip13Gt/Gt testis with uniform pachytene arrest.\n(G) Trip13Gt/Gt 3-mo-old testis with some postmeiotic spermatids (arrows).\n(H) Spo11−/- testis. A tubule with spermatocytes at leptotene/zygotene transition is labeled ZP, and tubules with apoptotic spermatocytes are marked with an asterisk. The specimen was taken from a littermate of that in (I).\n(I) Spo11 −/− Trip13Gt/Gt testis. Labeling is the same as in (H). The inset contains a tubule with leptotene-zygotene spermatocytes.\n(J) Mei1 −/− Trip13Gt/+ testis. The specimen was taken from a littermate of that in (K).\n(K) Mei1 −/− Trip13Gt/Gt testis.\n(L) Rec8Mei8/Rec8Mei8 Trip13Gt/+ testis. The Rec8Mei8 allele was described [39]. The specimen was taken from a littermate of that in (M).\n(M) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt testis.\n(N) Dmc1 −/− Trip13Gt/Gt testis.\n(O) Spo11 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (P).\n(P) Spo11 −/− Trip13Gt/Gt 25-d-old ovary.\n(Q) Mei1 −/− Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (R).\n(R) Mei1 −/− Trip13Gt/Gt 25-d-old ovary.\n(S) Rec8Mei8/Rec8Mei8 Trip13Gt/+ 25-d-old ovary. The specimen was taken from a littermate of that in (T).\n(T) Rec8Mei8/Rec8Mei8 Trip13Gt/Gt 25-d-old ovary."}