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{"project":"craft-ca-core-dev","denotations":[{"id":"T27179","span":{"begin":480,"end":492},"obj":"GO:0022008"},{"id":"T27180","span":{"begin":562,"end":567},"obj":"PR:000028775"},{"id":"T27181","span":{"begin":584,"end":589},"obj":"SO:0000704"},{"id":"T27182","span":{"begin":593,"end":604},"obj":"GO:0005737"},{"id":"T27183","span":{"begin":634,"end":641},"obj":"CL:0000540"},{"id":"T27184","span":{"begin":684,"end":690},"obj":"UBERON:0000966"},{"id":"T27185","span":{"begin":709,"end":725},"obj":"CL:0000561"},{"id":"T27167","span":{"begin":0,"end":5},"obj":"PR:000028775"},{"id":"T27168","span":{"begin":150,"end":161},"obj":"GO:0005737"},{"id":"T27169","span":{"begin":163,"end":168},"obj":"PR:000028775"},{"id":"T27170","span":{"begin":201,"end":205},"obj":"SO:0000704"},{"id":"T27171","span":{"begin":206,"end":216},"obj":"GO:0065007"},{"id":"T27172","span":{"begin":257,"end":265},"obj":"GO:0065007"},{"id":"T27173","span":{"begin":282,"end":287},"obj":"SO:0000704"},{"id":"T27174","span":{"begin":301,"end":311},"obj":"GO:0007049"},{"id":"T27175","span":{"begin":332,"end":338},"obj":"PR:000003090"},{"id":"T27176","span":{"begin":345,"end":356},"obj":"GO:0005737"},{"id":"T27177","span":{"begin":451,"end":458},"obj":"GO:0005634"},{"id":"T27178","span":{"begin":463,"end":472},"obj":"GO:0005737"}],"text":"E2f3a could disrupt SAC differentiation through its well known role as a transcriptional activator, or, in view of the discovery that it is partially cytoplasmic, E2f3a may affect processes other than gene regulation. Both scenarios are feasible since E2fs regulate differentiation genes [44–48], and cell cycle regulators, such as Cdkn1b, have cytoplasmic activities that influence differentiation [68,69]. Many transcription factors shuttle between nucleus and cytoplasm during neurogenesis (e.g., [70] and references therein). It may be difficult to identify E2f3a-specific target genes or cytoplasmic proteins in SACs since these neurons are a small proportion (\u003c1%) of the total retina and only ~5.2% of amacrine neurons [38]."}

{"project":"2_test","denotations":[{"id":"17608565-11159908-84869034","span":{"begin":289,"end":291},"obj":"11159908"},{"id":"17608565-12110166-84869034","span":{"begin":289,"end":291},"obj":"12110166"},{"id":"17608565-12975318-84869034","span":{"begin":289,"end":291},"obj":"12975318"},{"id":"17608565-15479636-84869034","span":{"begin":289,"end":291},"obj":"15479636"},{"id":"17608565-16081278-84869034","span":{"begin":289,"end":291},"obj":"16081278"},{"id":"17608565-16705040-84869035","span":{"begin":400,"end":402},"obj":"16705040"},{"id":"17608565-15078817-84869036","span":{"begin":403,"end":405},"obj":"15078817"},{"id":"17608565-17043310-84869037","span":{"begin":501,"end":503},"obj":"17043310"},{"id":"17608565-9786999-84869038","span":{"begin":727,"end":729},"obj":"9786999"},{"id":"T68946","span":{"begin":289,"end":291},"obj":"11159908"},{"id":"T3612","span":{"begin":289,"end":291},"obj":"12110166"},{"id":"T53323","span":{"begin":289,"end":291},"obj":"12975318"},{"id":"T58579","span":{"begin":289,"end":291},"obj":"15479636"},{"id":"T65898","span":{"begin":289,"end":291},"obj":"16081278"},{"id":"T53939","span":{"begin":400,"end":402},"obj":"16705040"},{"id":"T93030","span":{"begin":403,"end":405},"obj":"15078817"},{"id":"T27591","span":{"begin":501,"end":503},"obj":"17043310"},{"id":"T75934","span":{"begin":727,"end":729},"obj":"9786999"}],"text":"E2f3a could disrupt SAC differentiation through its well known role as a transcriptional activator, or, in view of the discovery that it is partially cytoplasmic, E2f3a may affect processes other than gene regulation. Both scenarios are feasible since E2fs regulate differentiation genes [44–48], and cell cycle regulators, such as Cdkn1b, have cytoplasmic activities that influence differentiation [68,69]. Many transcription factors shuttle between nucleus and cytoplasm during neurogenesis (e.g., [70] and references therein). It may be difficult to identify E2f3a-specific target genes or cytoplasmic proteins in SACs since these neurons are a small proportion (\u003c1%) of the total retina and only ~5.2% of amacrine neurons [38]."}