Id |
Subject |
Object |
Predicate |
Lexical cue |
T27309 |
473-479 |
IN |
denotes |
during |
T27310 |
480-492 |
NN |
denotes |
neurogenesis |
T27226 |
0-5 |
NN |
denotes |
E2f3a |
T27227 |
12-19 |
VB |
denotes |
disrupt |
T27228 |
6-11 |
MD |
denotes |
could |
T27229 |
20-23 |
NN |
denotes |
SAC |
T27230 |
24-39 |
NN |
denotes |
differentiation |
T27231 |
40-47 |
IN |
denotes |
through |
T27232 |
48-51 |
PRP$ |
denotes |
its |
T27233 |
63-67 |
NN |
denotes |
role |
T27234 |
52-56 |
RB |
denotes |
well |
T27235 |
57-62 |
VBN |
denotes |
known |
T27236 |
68-70 |
IN |
denotes |
as |
T27237 |
71-72 |
DT |
denotes |
a |
T27238 |
89-98 |
NN |
denotes |
activator |
T27239 |
73-88 |
JJ |
denotes |
transcriptional |
T27240 |
98-100 |
, |
denotes |
, |
T27241 |
100-102 |
CC |
denotes |
or |
T27242 |
102-104 |
, |
denotes |
, |
T27243 |
104-106 |
IN |
denotes |
in |
T27244 |
173-179 |
VB |
denotes |
affect |
T27245 |
107-111 |
NN |
denotes |
view |
T27246 |
112-114 |
IN |
denotes |
of |
T27247 |
115-118 |
DT |
denotes |
the |
T27248 |
119-128 |
NN |
denotes |
discovery |
T27249 |
129-133 |
IN |
denotes |
that |
T27250 |
137-139 |
VBZ |
denotes |
is |
T27251 |
134-136 |
PRP |
denotes |
it |
T27252 |
140-149 |
RB |
denotes |
partially |
T27253 |
150-161 |
JJ |
denotes |
cytoplasmic |
T27254 |
161-163 |
, |
denotes |
, |
T27255 |
163-168 |
NN |
denotes |
E2f3a |
T27256 |
169-172 |
MD |
denotes |
may |
T27257 |
180-189 |
NNS |
denotes |
processes |
T27258 |
190-195 |
JJ |
denotes |
other |
T27259 |
196-200 |
IN |
denotes |
than |
T27260 |
201-205 |
NN |
denotes |
gene |
T27261 |
206-216 |
NN |
denotes |
regulation |
T27262 |
216-217 |
. |
denotes |
. |
T27263 |
217-407 |
sentence |
denotes |
Both scenarios are feasible since E2fs regulate differentiation genes [44–48], and cell cycle regulators, such as Cdkn1b, have cytoplasmic activities that influence differentiation [68,69]. |
T27264 |
218-222 |
DT |
denotes |
Both |
T27265 |
223-232 |
NNS |
denotes |
scenarios |
T27266 |
233-236 |
VBP |
denotes |
are |
T27267 |
237-245 |
JJ |
denotes |
feasible |
T27268 |
246-251 |
IN |
denotes |
since |
T27269 |
257-265 |
VBP |
denotes |
regulate |
T27270 |
252-256 |
NNS |
denotes |
E2fs |
T27271 |
266-281 |
NN |
denotes |
differentiation |
T27272 |
282-287 |
NNS |
denotes |
genes |
T27273 |
288-289 |
-LRB- |
denotes |
[ |
T27274 |
289-291 |
CD |
denotes |
44 |
T27275 |
291-292 |
SYM |
denotes |
– |
T27276 |
292-294 |
CD |
denotes |
48 |
T27277 |
294-295 |
-RRB- |
denotes |
] |
T27278 |
295-297 |
, |
denotes |
, |
T27279 |
297-300 |
CC |
denotes |
and |
T27280 |
301-305 |
NN |
denotes |
cell |
T27281 |
306-311 |
NN |
denotes |
cycle |
T27282 |
312-322 |
NNS |
denotes |
regulators |
T27283 |
340-344 |
VBP |
denotes |
have |
T27284 |
322-324 |
, |
denotes |
, |
T27285 |
324-328 |
JJ |
denotes |
such |
T27286 |
329-331 |
IN |
denotes |
as |
T27287 |
332-338 |
NN |
denotes |
Cdkn1b |
T27288 |
338-340 |
, |
denotes |
, |
T27289 |
345-356 |
JJ |
denotes |
cytoplasmic |
T27290 |
357-367 |
NNS |
denotes |
activities |
T27291 |
368-372 |
WDT |
denotes |
that |
T27292 |
373-382 |
VBP |
denotes |
influence |
T27293 |
383-398 |
NN |
denotes |
differentiation |
T27294 |
399-400 |
-LRB- |
denotes |
[ |
T27295 |
403-405 |
CD |
denotes |
69 |
T27296 |
400-402 |
CD |
denotes |
68 |
T27297 |
402-403 |
, |
denotes |
, |
T27298 |
405-406 |
-RRB- |
denotes |
] |
T27299 |
406-407 |
. |
denotes |
. |
T27300 |
407-529 |
sentence |
denotes |
Many transcription factors shuttle between nucleus and cytoplasm during neurogenesis (e.g., [70] and references therein). |
T27301 |
408-412 |
JJ |
denotes |
Many |
T27302 |
427-434 |
NNS |
denotes |
factors |
T27303 |
413-426 |
NN |
denotes |
transcription |
T27304 |
435-442 |
VBP |
denotes |
shuttle |
T27305 |
443-450 |
IN |
denotes |
between |
T27306 |
451-458 |
NN |
denotes |
nucleus |
T27307 |
459-462 |
CC |
denotes |
and |
T27308 |
463-472 |
NN |
denotes |
cytoplasm |
T27311 |
493-494 |
-LRB- |
denotes |
( |
T27312 |
501-503 |
CD |
denotes |
70 |
T27313 |
494-498 |
FW |
denotes |
e.g. |
T27314 |
498-500 |
, |
denotes |
, |
T27315 |
500-501 |
-LRB- |
denotes |
[ |
T27316 |
503-504 |
-RRB- |
denotes |
] |
T27317 |
505-508 |
CC |
denotes |
and |
T27318 |
509-519 |
NNS |
denotes |
references |
T27319 |
520-527 |
RB |
denotes |
therein |
T27320 |
527-528 |
-RRB- |
denotes |
) |
T27321 |
528-529 |
. |
denotes |
. |
T27322 |
529-731 |
sentence |
denotes |
It may be difficult to identify E2f3a-specific target genes or cytoplasmic proteins in SACs since these neurons are a small proportion (<1%) of the total retina and only ~5.2% of amacrine neurons [38]. |
T27323 |
530-532 |
PRP |
denotes |
It |
T27324 |
537-539 |
VB |
denotes |
be |
T27325 |
533-536 |
MD |
denotes |
may |
T27326 |
540-549 |
JJ |
denotes |
difficult |
T27327 |
550-552 |
TO |
denotes |
to |
T27328 |
553-561 |
VB |
denotes |
identify |
T27329 |
562-567 |
NN |
denotes |
E2f3a |
T27330 |
568-576 |
JJ |
denotes |
specific |
T27331 |
567-568 |
HYPH |
denotes |
- |
T27332 |
584-589 |
NNS |
denotes |
genes |
T27333 |
577-583 |
NN |
denotes |
target |
T27334 |
590-592 |
CC |
denotes |
or |
T27335 |
593-604 |
JJ |
denotes |
cytoplasmic |
T27336 |
605-613 |
NN |
denotes |
proteins |
T27337 |
614-616 |
IN |
denotes |
in |
T27338 |
617-621 |
NNS |
denotes |
SACs |
T27339 |
622-627 |
IN |
denotes |
since |
T27340 |
642-645 |
VBP |
denotes |
are |
T27341 |
628-633 |
DT |
denotes |
these |
T27342 |
634-641 |
NNS |
denotes |
neurons |
T27343 |
646-647 |
DT |
denotes |
a |
T27344 |
654-664 |
NN |
denotes |
proportion |
T27345 |
648-653 |
JJ |
denotes |
small |
T27346 |
665-666 |
-LRB- |
denotes |
( |
T27347 |
666-667 |
SYM |
denotes |
< |
T27348 |
667-668 |
CD |
denotes |
1 |
T27349 |
668-669 |
NN |
denotes |
% |
T27350 |
669-670 |
-RRB- |
denotes |
) |
T27351 |
671-673 |
IN |
denotes |
of |
T27352 |
674-677 |
DT |
denotes |
the |
T27353 |
684-690 |
NN |
denotes |
retina |
T27354 |
678-683 |
JJ |
denotes |
total |
T27355 |
691-694 |
CC |
denotes |
and |
T27356 |
695-699 |
RB |
denotes |
only |
T27357 |
701-704 |
CD |
denotes |
5.2 |
T27358 |
700-701 |
SYM |
denotes |
~ |
T27359 |
704-705 |
NN |
denotes |
% |
T27360 |
706-708 |
IN |
denotes |
of |
T27361 |
709-717 |
JJ |
denotes |
amacrine |
T27362 |
718-725 |
NNS |
denotes |
neurons |
T27363 |
726-727 |
-LRB- |
denotes |
[ |
T27364 |
727-729 |
CD |
denotes |
38 |
T27365 |
729-730 |
-RRB- |
denotes |
] |
T27366 |
730-731 |
. |
denotes |
. |
R8116 |
T27226 |
T27227 |
nsubj |
E2f3a,disrupt |
R8117 |
T27228 |
T27227 |
aux |
could,disrupt |
R8118 |
T27229 |
T27230 |
compound |
SAC,differentiation |
R8119 |
T27230 |
T27227 |
dobj |
differentiation,disrupt |
R8120 |
T27231 |
T27227 |
prep |
through,disrupt |
R8121 |
T27232 |
T27233 |
poss |
its,role |
R8122 |
T27233 |
T27231 |
pobj |
role,through |
R8123 |
T27234 |
T27235 |
advmod |
well,known |
R8124 |
T27235 |
T27233 |
amod |
known,role |
R8125 |
T27236 |
T27233 |
prep |
as,role |
R8126 |
T27237 |
T27238 |
det |
a,activator |
R8127 |
T27238 |
T27236 |
pobj |
activator,as |
R8128 |
T27239 |
T27238 |
amod |
transcriptional,activator |
R8129 |
T27240 |
T27227 |
punct |
", ",disrupt |
R8130 |
T27241 |
T27227 |
cc |
or,disrupt |
R8131 |
T27242 |
T27227 |
punct |
", ",disrupt |
R8132 |
T27243 |
T27244 |
prep |
in,affect |
R8133 |
T27244 |
T27227 |
conj |
affect,disrupt |
R8134 |
T27245 |
T27243 |
pobj |
view,in |
R8135 |
T27246 |
T27245 |
prep |
of,view |
R8136 |
T27247 |
T27248 |
det |
the,discovery |
R8137 |
T27248 |
T27246 |
pobj |
discovery,of |
R8138 |
T27249 |
T27250 |
mark |
that,is |
R8139 |
T27250 |
T27248 |
acl |
is,discovery |
R8140 |
T27251 |
T27250 |
nsubj |
it,is |
R8141 |
T27252 |
T27253 |
advmod |
partially,cytoplasmic |
R8142 |
T27253 |
T27250 |
acomp |
cytoplasmic,is |
R8143 |
T27254 |
T27244 |
punct |
", ",affect |
R8144 |
T27255 |
T27244 |
nsubj |
E2f3a,affect |
R8145 |
T27256 |
T27244 |
aux |
may,affect |
R8146 |
T27257 |
T27244 |
dobj |
processes,affect |
R8147 |
T27258 |
T27257 |
amod |
other,processes |
R8148 |
T27259 |
T27258 |
prep |
than,other |
R8149 |
T27260 |
T27261 |
compound |
gene,regulation |
R8150 |
T27261 |
T27259 |
pobj |
regulation,than |
R8151 |
T27262 |
T27244 |
punct |
.,affect |
R8152 |
T27264 |
T27265 |
det |
Both,scenarios |
R8153 |
T27265 |
T27266 |
nsubj |
scenarios,are |
R8154 |
T27267 |
T27266 |
acomp |
feasible,are |
R8155 |
T27268 |
T27269 |
mark |
since,regulate |
R8156 |
T27269 |
T27266 |
advcl |
regulate,are |
R8157 |
T27270 |
T27269 |
nsubj |
E2fs,regulate |
R8158 |
T27271 |
T27272 |
compound |
differentiation,genes |
R8159 |
T27272 |
T27269 |
dobj |
genes,regulate |
R8160 |
T27273 |
T27274 |
punct |
[,44 |
R8161 |
T27274 |
T27266 |
parataxis |
44,are |
R8162 |
T27275 |
T27276 |
punct |
–,48 |
R8163 |
T27276 |
T27274 |
prep |
48,44 |
R8164 |
T27277 |
T27274 |
punct |
],44 |
R8165 |
T27278 |
T27266 |
punct |
", ",are |
R8166 |
T27279 |
T27266 |
cc |
and,are |
R8167 |
T27280 |
T27281 |
compound |
cell,cycle |
R8168 |
T27281 |
T27282 |
compound |
cycle,regulators |
R8169 |
T27282 |
T27283 |
nsubj |
regulators,have |
R8170 |
T27283 |
T27266 |
conj |
have,are |
R8171 |
T27284 |
T27282 |
punct |
", ",regulators |
R8172 |
T27285 |
T27286 |
amod |
such,as |
R8173 |
T27286 |
T27282 |
prep |
as,regulators |
R8174 |
T27287 |
T27286 |
pobj |
Cdkn1b,as |
R8175 |
T27288 |
T27283 |
punct |
", ",have |
R8176 |
T27289 |
T27290 |
amod |
cytoplasmic,activities |
R8177 |
T27290 |
T27283 |
dobj |
activities,have |
R8178 |
T27291 |
T27292 |
dep |
that,influence |
R8179 |
T27292 |
T27290 |
relcl |
influence,activities |
R8180 |
T27293 |
T27292 |
dobj |
differentiation,influence |
R8181 |
T27294 |
T27295 |
punct |
[,69 |
R8182 |
T27295 |
T27283 |
parataxis |
69,have |
R8183 |
T27296 |
T27295 |
nummod |
68,69 |
R8184 |
T27297 |
T27295 |
punct |
",",69 |
R8185 |
T27298 |
T27295 |
punct |
],69 |
R8186 |
T27299 |
T27283 |
punct |
.,have |
R8187 |
T27301 |
T27302 |
amod |
Many,factors |
R8188 |
T27302 |
T27304 |
nsubj |
factors,shuttle |
R8189 |
T27303 |
T27302 |
compound |
transcription,factors |
R8190 |
T27305 |
T27304 |
prep |
between,shuttle |
R8191 |
T27306 |
T27305 |
pobj |
nucleus,between |
R8192 |
T27307 |
T27306 |
cc |
and,nucleus |
R8193 |
T27308 |
T27306 |
conj |
cytoplasm,nucleus |
R8194 |
T27309 |
T27304 |
prep |
during,shuttle |
R8195 |
T27310 |
T27309 |
pobj |
neurogenesis,during |
R8196 |
T27311 |
T27312 |
punct |
(,70 |
R8197 |
T27312 |
T27304 |
parataxis |
70,shuttle |
R8198 |
T27313 |
T27312 |
advmod |
e.g.,70 |
R8199 |
T27314 |
T27312 |
punct |
", ",70 |
R8200 |
T27315 |
T27312 |
punct |
[,70 |
R8201 |
T27316 |
T27312 |
punct |
],70 |
R8202 |
T27317 |
T27312 |
cc |
and,70 |
R8203 |
T27318 |
T27312 |
conj |
references,70 |
R8204 |
T27319 |
T27318 |
advmod |
therein,references |
R8205 |
T27320 |
T27312 |
punct |
),70 |
R8206 |
T27321 |
T27304 |
punct |
.,shuttle |
R8207 |
T27323 |
T27324 |
nsubj |
It,be |
R8208 |
T27325 |
T27324 |
aux |
may,be |
R8209 |
T27326 |
T27324 |
acomp |
difficult,be |
R8210 |
T27327 |
T27328 |
aux |
to,identify |
R8211 |
T27328 |
T27324 |
xcomp |
identify,be |
R8212 |
T27329 |
T27330 |
npadvmod |
E2f3a,specific |
R8213 |
T27330 |
T27332 |
amod |
specific,genes |
R8214 |
T27331 |
T27330 |
punct |
-,specific |
R8215 |
T27332 |
T27328 |
dobj |
genes,identify |
R8216 |
T27333 |
T27332 |
compound |
target,genes |
R8217 |
T27334 |
T27332 |
cc |
or,genes |
R8218 |
T27335 |
T27336 |
amod |
cytoplasmic,proteins |
R8219 |
T27336 |
T27332 |
conj |
proteins,genes |
R8220 |
T27337 |
T27328 |
prep |
in,identify |
R8221 |
T27338 |
T27337 |
pobj |
SACs,in |
R8222 |
T27339 |
T27340 |
mark |
since,are |
R8223 |
T27340 |
T27324 |
advcl |
are,be |
R8224 |
T27341 |
T27342 |
det |
these,neurons |
R8225 |
T27342 |
T27340 |
nsubj |
neurons,are |
R8226 |
T27343 |
T27344 |
det |
a,proportion |
R8227 |
T27344 |
T27340 |
attr |
proportion,are |
R8228 |
T27345 |
T27344 |
amod |
small,proportion |
R8229 |
T27346 |
T27344 |
punct |
(,proportion |
R8230 |
T27347 |
T27348 |
punct |
<,1 |
R8231 |
T27348 |
T27349 |
nummod |
1,% |
R8232 |
T27349 |
T27344 |
appos |
%,proportion |
R8233 |
T27350 |
T27344 |
punct |
),proportion |
R8234 |
T27351 |
T27344 |
prep |
of,proportion |
R8235 |
T27352 |
T27353 |
det |
the,retina |
R8236 |
T27353 |
T27351 |
pobj |
retina,of |
R8237 |
T27354 |
T27353 |
amod |
total,retina |
R8238 |
T27355 |
T27344 |
cc |
and,proportion |
R8239 |
T27356 |
T27357 |
advmod |
only,5.2 |
R8240 |
T27357 |
T27359 |
nummod |
5.2,% |
R8241 |
T27358 |
T27357 |
punct |
~,5.2 |
R8242 |
T27359 |
T27344 |
conj |
%,proportion |
R8243 |
T27360 |
T27359 |
prep |
of,% |
R8244 |
T27361 |
T27362 |
amod |
amacrine,neurons |
R8245 |
T27362 |
T27360 |
pobj |
neurons,of |
R8246 |
T27363 |
T27364 |
punct |
[,38 |
R8247 |
T27364 |
T27340 |
parataxis |
38,are |
R8248 |
T27365 |
T27364 |
punct |
],38 |
R8249 |
T27366 |
T27324 |
punct |
.,be |