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Id Subject Object Predicate Lexical cue
T24609 0-2 NN denotes Rb
T24610 3-11 VBZ denotes Controls
T24611 12-15 NN denotes SAC
T24612 16-31 NN denotes Differentiation
T24613 32-39 IN denotes through
T24614 40-45 NN denotes E2f3a
T24615 45-203 sentence denotes Comprehensive marker analysis revealed that, in striking contrast to other retinal neurons, E2f1 deletion did not suppress defects in Rb KO cholinergic SACs.
T24616 46-59 JJ denotes Comprehensive
T24617 67-75 NN denotes analysis
T24618 60-66 NN denotes marker
T24619 76-84 VBD denotes revealed
T24620 85-89 IN denotes that
T24621 160-168 VB denotes suppress
T24622 89-91 , denotes ,
T24623 91-93 IN denotes in
T24624 94-102 JJ denotes striking
T24625 103-111 NN denotes contrast
T24626 112-114 IN denotes to
T24627 115-120 JJ denotes other
T24628 129-136 NNS denotes neurons
T24629 121-128 JJ denotes retinal
T24630 136-138 , denotes ,
T24631 138-142 NN denotes E2f1
T24632 143-151 NN denotes deletion
T24633 152-155 VBD denotes did
T24634 156-159 RB denotes not
T24635 169-176 NNS denotes defects
T24636 177-179 IN denotes in
T24637 180-182 NN denotes Rb
T24638 183-185 NN denotes KO
T24639 198-202 NNS denotes SACs
T24640 186-197 JJ denotes cholinergic
T24641 202-203 . denotes .
T24642 203-315 sentence denotes Instead, we observed E2f1-independent defects in the synthesis and transport of a large cohort of SAC proteins.
T24643 204-211 RB denotes Instead
T24644 216-224 VBD denotes observed
T24645 211-213 , denotes ,
T24646 213-215 PRP denotes we
T24647 225-229 NN denotes E2f1
T24648 230-241 JJ denotes independent
T24649 229-230 HYPH denotes -
T24650 242-249 NNS denotes defects
T24651 250-252 IN denotes in
T24652 253-256 DT denotes the
T24653 257-266 NN denotes synthesis
T24654 267-270 CC denotes and
T24655 271-280 NN denotes transport
T24656 281-283 IN denotes of
T24657 284-285 DT denotes a
T24658 292-298 NN denotes cohort
T24659 286-291 JJ denotes large
T24660 299-301 IN denotes of
T24661 302-305 NN denotes SAC
T24662 306-314 NN denotes proteins
T24663 314-315 . denotes .
T24664 315-528 sentence denotes These data expand insight into the development of these important interneurons, but more critically, provide to our knowledge the first unambiguous evidence that Rb regulates neurogenesis beyond terminal mitosis.
T24665 316-321 DT denotes These
T24666 322-326 NNS denotes data
T24667 327-333 VBP denotes expand
T24668 334-341 NN denotes insight
T24669 342-346 IN denotes into
T24670 347-350 DT denotes the
T24671 351-362 NN denotes development
T24672 363-365 IN denotes of
T24673 366-371 DT denotes these
T24674 382-394 NNS denotes interneurons
T24675 372-381 JJ denotes important
T24676 394-396 , denotes ,
T24677 396-399 CC denotes but
T24678 400-404 RBR denotes more
T24679 405-415 RB denotes critically
T24680 417-424 VB denotes provide
T24681 415-417 , denotes ,
T24682 425-427 IN denotes to
T24683 428-431 PRP$ denotes our
T24684 432-441 NN denotes knowledge
T24685 442-445 DT denotes the
T24686 464-472 NN denotes evidence
T24687 446-451 JJ denotes first
T24688 452-463 JJ denotes unambiguous
T24689 473-477 IN denotes that
T24690 481-490 VBZ denotes regulates
T24691 478-480 NN denotes Rb
T24692 491-503 NN denotes neurogenesis
T24693 504-510 IN denotes beyond
T24694 511-519 JJ denotes terminal
T24695 520-527 NN denotes mitosis
T24696 527-528 . denotes .
T24697 528-748 sentence denotes Rb binds more than 100 factors [43], and in several non-neuronal cells, such as skeletal muscle, adipocytes, and bone, it binds and potentiates tissue-specific transcription factors that promote differentiation [31–33].
T24698 529-531 NN denotes Rb
T24699 532-537 VBZ denotes binds
T24700 538-542 JJR denotes more
T24701 548-551 CD denotes 100
T24702 543-547 IN denotes than
T24703 552-559 NNS denotes factors
T24704 560-561 -LRB- denotes [
T24705 561-563 CD denotes 43
T24706 563-564 -RRB- denotes ]
T24707 564-566 , denotes ,
T24708 566-569 CC denotes and
T24709 570-572 IN denotes in
T24710 651-656 VBZ denotes binds
T24711 573-580 JJ denotes several
T24712 594-599 NNS denotes cells
T24713 581-593 JJ denotes non-neuronal
T24714 599-601 , denotes ,
T24715 601-605 JJ denotes such
T24716 606-608 IN denotes as
T24738 743-744 SYM denotes –
T24739 744-746 CD denotes 33
T24740 746-747 -RRB- denotes ]
T24741 747-748 . denotes .
T24742 748-921 sentence denotes The idea that Rb promotes muscle differentiation by potentiating Myod1 activity was contested [61], and other mechanisms proposed [62,63], but not involving E2f repression.
T24743 749-752 DT denotes The
T24744 753-757 NN denotes idea
T24745 833-842 VBN denotes contested
T24746 758-762 IN denotes that
T24747 766-774 VBZ denotes promotes
T24748 763-765 NN denotes Rb
T24749 775-781 NN denotes muscle
T24750 782-797 NN denotes differentiation
T24751 798-800 IN denotes by
T24752 801-813 VBG denotes potentiating
T24753 814-819 NN denotes Myod1
T24754 820-828 NN denotes activity
T24755 829-832 VBD denotes was
T24756 843-844 -LRB- denotes [
T24757 844-846 CD denotes 61
T24758 846-847 -RRB- denotes ]
T24759 847-849 , denotes ,
T24760 849-852 CC denotes and
T24761 853-858 JJ denotes other
T24762 859-869 NNS denotes mechanisms
T24763 870-878 VBN denotes proposed
T24764 879-880 -LRB- denotes [
T24765 883-885 CD denotes 63
T24766 880-882 CD denotes 62
T24767 882-883 , denotes ,
T24768 885-886 -RRB- denotes ]
T24769 886-888 , denotes ,
T24770 888-891 CC denotes but
T24771 896-905 VBG denotes involving
T24772 892-895 RB denotes not
T24773 906-909 NN denotes E2f
T24774 910-920 NN denotes repression
T24775 920-921 . denotes .
T24776 921-1018 sentence denotes Strikingly, however, we discovered that Rb promotes SAC differentiation through E2f3 (Figure 8).
T24777 922-932 RB denotes Strikingly
T24778 946-956 VBD denotes discovered
T24779 932-934 , denotes ,
T24780 934-941 RB denotes however
T24781 941-943 , denotes ,
T24782 943-945 PRP denotes we
T24783 957-961 IN denotes that
T24784 965-973 VBZ denotes promotes
T24785 962-964 NN denotes Rb
T24786 974-977 NN denotes SAC
T24787 978-993 NN denotes differentiation
T24788 994-1001 IN denotes through
T24789 1002-1006 NN denotes E2f3
T24790 1007-1008 -LRB- denotes (
T24791 1008-1014 NN denotes Figure
T24792 1015-1016 CD denotes 8
T24793 1016-1017 -RRB- denotes )
T24794 1017-1018 . denotes .
T24795 1018-1019 sentence denotes
T24796 1029-1035 sentence denotes Rb Reg
T24797 1029-1031 NN denotes Rb
T24798 1032-1034 NNS denotes Re
T24799 1034-1035 IN denotes g
T24826 1771-1774 PRP$ denotes its
T24827 1775-1779 NN denotes role
T24828 1780-1782 IN denotes in
T24829 1783-1794 VBG denotes controlling
T24830 1795-1803 NN denotes division
T24831 1804-1806 CC denotes or
T24832 1807-1812 NN denotes death
T24833 1812-1814 : denotes :
T24834 1814-1818 NN denotes E2f3
T24835 1819-1827 NN denotes deletion
T24836 1836-1838 NN denotes Rb
T24837 1839-1841 NN denotes KO
T24838 1846-1853 NNS denotes defects
T24839 1842-1845 NN denotes SAC
T24840 1854-1857 CC denotes but
T24841 1858-1861 VBD denotes did
T24842 1866-1874 VB denotes suppress
T24843 1862-1865 RB denotes not
T24844 1875-1883 JJ denotes aberrant
T24845 1884-1897 NN denotes proliferation
T24846 1898-1900 CC denotes or
T24847 1901-1906 NN denotes death
T24848 1906-1908 , denotes ,
T24849 1908-1915 IN denotes whereas
T24850 1930-1938 VBD denotes reversed
T24851 1916-1920 NN denotes E2f1
T24852 1921-1929 NN denotes deletion
T24853 1939-1947 JJ denotes abnormal
T24854 1948-1961 NN denotes proliferation
T24855 1962-1965 CC denotes and
T24856 1966-1971 NN denotes death
T24857 1972-1975 CC denotes but
T24858 1976-1979 VBD denotes did
T24859 1984-1990 VB denotes rescue
T24860 1980-1983 RB denotes not
T24861 1991-1994 NN denotes SAC
T24862 1995-2010 NN denotes differentiation
T24863 2010-2011 . denotes .
T24864 2011-2099 sentence denotes Double labelling confirmed that E2f1 but not E2f3 deletion reversed Rb KO SAC division.
T24865 2012-2018 JJ denotes Double
T24866 2019-2028 NN denotes labelling
T24867 2029-2038 VBD denotes confirmed
T24868 2039-2043 IN denotes that
T24869 2071-2079 VBD denotes reversed
T24870 2044-2048 NN denotes E2f1
T24871 2062-2070 NN denotes deletion
T24872 2049-2052 CC denotes but
T24873 2053-2056 RB denotes not
T24874 2057-2061 NN denotes E2f3
T24875 2080-2082 NN denotes Rb
T24876 2083-2085 NN denotes KO
T24877 2086-2089 NN denotes SAC
T24878 2090-2098 NN denotes division
T24879 2098-2099 . denotes .
T24880 2099-2225 sentence denotes Moreover, deleting E2f1, but not E2f3, reversed deregulated expression of cell cycle and apoptotic genes in the Rb KO retina.
T24881 2100-2108 RB denotes Moreover
T24882 2139-2147 VBD denotes reversed
T24883 2108-2110 , denotes ,
T24884 2110-2118 VBG denotes deleting
T24885 2119-2123 NN denotes E2f1
T24886 2123-2125 , denotes ,
T24887 2125-2128 CC denotes but
T24888 2129-2132 RB denotes not
T24889 2133-2137 NN denotes E2f3
T24890 2137-2139 , denotes ,
T24891 2148-2159 VBN denotes deregulated
T24892 2160-2170 NN denotes expression
T24893 2171-2173 IN denotes of
T24894 2174-2178 NN denotes cell
T24895 2179-2184 NN denotes cycle
T24896 2185-2188 CC denotes and
T24897 2189-2198 JJ denotes apoptotic
T24898 2199-2204 NNS denotes genes
T24899 2205-2207 IN denotes in
T24900 2208-2211 DT denotes the
T24901 2218-2224 NN denotes retina
T24902 2212-2214 NN denotes Rb
T24903 2215-2217 NN denotes KO
T24904 2224-2225 . denotes .
T24905 2225-2366 sentence denotes E2f3 is expressed in a subset of CNS neurons (this work) and drives specific cell-cycle–independent defects in Rb KO forebrain neurons [53].
T24906 2226-2230 NN denotes E2f3
T24907 2234-2243 VBN denotes expressed
T24908 2231-2233 VBZ denotes is
T24909 2244-2246 IN denotes in
T24910 2247-2248 DT denotes a
T24911 2249-2255 NN denotes subset
T24912 2256-2258 IN denotes of
T24913 2259-2262 NN denotes CNS
T24914 2263-2270 NNS denotes neurons
T24915 2271-2272 -LRB- denotes (
T24916 2277-2281 NN denotes work
T24917 2272-2276 DT denotes this
T24918 2281-2282 -RRB- denotes )
T24919 2283-2286 CC denotes and
T24920 2287-2293 VBZ denotes drives
T24921 2294-2302 JJ denotes specific
T24922 2326-2333 NNS denotes defects
T24923 2303-2307 NN denotes cell
T24924 2308-2313 NN denotes cycle
T24925 2307-2308 HYPH denotes -
T24926 2314-2325 JJ denotes independent
T24927 2313-2314 HYPH denotes –
T24928 2334-2336 IN denotes in
T24929 2337-2339 NN denotes Rb
T24930 2340-2342 NN denotes KO
T24931 2353-2360 NNS denotes neurons
T24932 2343-2352 NN denotes forebrain
T24933 2361-2362 -LRB- denotes [
T24934 2362-2364 CD denotes 53
T24935 2364-2365 -RRB- denotes ]
T24936 2365-2366 . denotes .
T24937 2366-2496 sentence denotes Thus, E2f3 inhibition is the first, and may be the only, mechanism by which Rb participates directly in neuronal differentiation.
T24938 2367-2371 RB denotes Thus
T24939 2389-2391 VBZ denotes is
T24940 2371-2373 , denotes ,
T24941 2373-2377 NN denotes E2f3
T24942 2378-2388 NN denotes inhibition
T24943 2392-2395 DT denotes the
T24944 2396-2401 JJ denotes first
T24945 2401-2403 , denotes ,
T24946 2403-2406 CC denotes and
T24947 2407-2410 MD denotes may
T24948 2411-2413 VB denotes be
T24949 2414-2417 DT denotes the
T24950 2418-2422 JJ denotes only
T24951 2422-2424 , denotes ,
T24952 2424-2433 NN denotes mechanism
T24953 2434-2436 IN denotes by
T24954 2446-2458 VBZ denotes participates
T24955 2437-2442 WDT denotes which
T24956 2443-2445 NN denotes Rb
T24957 2459-2467 RB denotes directly
T24958 2468-2470 IN denotes in
T24959 2471-2479 JJ denotes neuronal
T24960 2480-2495 NN denotes differentiation
T24961 2495-2496 . denotes .
T24962 2496-2623 sentence denotes To further dissect the mechanism of action of Rb in SACs we determined the E2f3 isoform it targets to promote differentiation.
T24963 2497-2499 TO denotes To
T24964 2508-2515 VB denotes dissect
T24965 2500-2507 RB denotes further
T24966 2557-2567 VBD denotes determined
T24967 2516-2519 DT denotes the
T24968 2520-2529 NN denotes mechanism
T24969 2530-2532 IN denotes of
T24970 2533-2539 NN denotes action
T24971 2540-2542 IN denotes of
T24972 2543-2545 NN denotes Rb
T24973 2546-2548 IN denotes in
T24974 2549-2553 NNS denotes SACs
T24975 2554-2556 PRP denotes we
T24976 2568-2571 DT denotes the
T24977 2577-2584 NN denotes isoform
T24978 2572-2576 NN denotes E2f3
T24979 2585-2587 PRP denotes it
T24980 2588-2595 VBZ denotes targets
T24981 2596-2598 TO denotes to
T24982 2599-2606 VB denotes promote
T24983 2607-2622 NN denotes differentiation
T24984 2622-2623 . denotes .
T24985 2623-2740 sentence denotes E2f3b was the primary candidate, since Rb and E2f3b collaborate to repress targets in quiescent cells in vitro [19].
T24986 2624-2629 NN denotes E2f3b
T24987 2630-2633 VBD denotes was
T24988 2634-2637 DT denotes the
T24989 2646-2655 NN denotes candidate
T24990 2638-2645 JJ denotes primary
T24991 2655-2657 , denotes ,
T24992 2657-2662 IN denotes since
T24993 2676-2687 VBP denotes collaborate
T24994 2663-2665 NN denotes Rb
T24995 2666-2669 CC denotes and
T24996 2670-2675 NN denotes E2f3b
T24997 2688-2690 TO denotes to
T24998 2691-2698 VB denotes repress
T24999 2699-2706 NNS denotes targets
T25000 2707-2709 IN denotes in
T25001 2710-2719 JJ denotes quiescent
T25002 2720-2725 NNS denotes cells
T25003 2726-2728 FW denotes in
T25004 2729-2734 FW denotes vitro
T25005 2735-2736 -LRB- denotes [
T25006 2736-2738 CD denotes 19
T25007 2738-2739 -RRB- denotes ]
T25008 2739-2740 . denotes .
T25009 2740-2943 sentence denotes However, in the first work to our knowledge to examine the function of any E2f protein isoform in vivo, we made the surprising observation that Rb regulates SAC differentiation through E2f3a (Figure 8).
T25010 2741-2748 RB denotes However
T25011 2848-2852 VBD denotes made
T25012 2748-2750 , denotes ,
T25013 2750-2752 IN denotes in
T25014 2753-2756 DT denotes the
T25015 2763-2767 NN denotes work
T25016 2757-2762 JJ denotes first
T25017 2768-2770 IN denotes to
T25018 2788-2795 VB denotes examine
T25019 2771-2774 PRP$ denotes our
T25020 2775-2784 NN denotes knowledge
T25021 2785-2787 TO denotes to
T25022 2796-2799 DT denotes the
T25023 2800-2808 NN denotes function
T25024 2809-2811 IN denotes of
T25025 2812-2815 DT denotes any
T25026 2828-2835 NN denotes isoform
T25027 2816-2819 NN denotes E2f
T25028 2820-2827 NN denotes protein
T25029 2836-2838 FW denotes in
T25030 2839-2843 FW denotes vivo
T25031 2843-2845 , denotes ,
T25032 2845-2847 PRP denotes we
T25033 2853-2856 DT denotes the
T25034 2868-2879 NN denotes observation
T25035 2857-2867 JJ denotes surprising
T25036 2880-2884 IN denotes that
T25037 2888-2897 VBZ denotes regulates
T25038 2885-2887 NN denotes Rb
T25039 2898-2901 NN denotes SAC
T25040 2902-2917 NN denotes differentiation
T25041 2918-2925 IN denotes through
T25042 2926-2931 NN denotes E2f3a
T25043 2932-2933 -LRB- denotes (
T25044 2933-2939 NN denotes Figure
T25045 2940-2941 CD denotes 8
T25046 2941-2942 -RRB- denotes )
T25047 2942-2943 . denotes .
T25048 2943-3109 sentence denotes Formally, we cannot exclude the possibility that deleting E2f3b might also rescue SAC differentiation, but definitive proof will require analysis of E2f3b null mice.
T25049 2944-2952 RB denotes Formally
T25050 2964-2971 VB denotes exclude
T25051 2952-2954 , denotes ,
T25052 2954-2956 PRP denotes we
T25053 2957-2960 MD denotes can
T25054 2960-2963 RB denotes not
T25055 2972-2975 DT denotes the
T25056 2976-2987 NN denotes possibility
T25057 2988-2992 IN denotes that
T25058 3019-3025 VB denotes rescue
T25059 2993-3001 VBG denotes deleting
T25060 3002-3007 NN denotes E2f3b
T25061 3008-3013 MD denotes might
T25062 3014-3018 RB denotes also
T25063 3026-3029 NN denotes SAC
T25064 3030-3045 NN denotes differentiation
T25065 3045-3047 , denotes ,
T25066 3047-3050 CC denotes but
T25067 3051-3061 JJ denotes definitive
T25068 3062-3067 NN denotes proof
T25069 3073-3080 VB denotes require
T25070 3068-3072 MD denotes will
T25071 3081-3089 NN denotes analysis
T25072 3090-3092 IN denotes of
T25073 3093-3098 NN denotes E2f3b
T25074 3099-3103 JJ denotes null
T25075 3104-3108 NNS denotes mice
T25076 3108-3109 . denotes .
T25077 3109-3224 sentence denotes Nevertheless, our data prove that Rb definitely regulates SAC differentiation through the activating E2f3 isoform.
T25078 3110-3122 RB denotes Nevertheless
T25079 3133-3138 VBP denotes prove
T25080 3122-3124 , denotes ,
T25081 3124-3127 PRP$ denotes our
T25082 3128-3132 NNS denotes data
T25083 3139-3143 IN denotes that
T25084 3158-3167 VBZ denotes regulates
T25085 3144-3146 NN denotes Rb
T25086 3147-3157 RB denotes definitely
T25087 3168-3171 NN denotes SAC
T25088 3172-3187 NN denotes differentiation
T25089 3188-3195 IN denotes through
T25090 3196-3199 DT denotes the
T25091 3216-3223 NN denotes isoform
T25092 3200-3210 VBG denotes activating
T25093 3211-3215 NN denotes E2f3
T25094 3223-3224 . denotes .
T38541 1029-1031 NN denotes Rb
T38542 1032-1041 VBZ denotes Regulates
T38543 1042-1050 JJ denotes Distinct
T38544 1051-1060 NNS denotes Processes
T38545 1061-1068 IN denotes through
T38546 1069-1073 NN denotes E2f1
T38547 1074-1077 CC denotes and
T38548 1078-1083 NN denotes E2f3a
T38549 1083-1133 sentence denotes Red text and arrows indicate Rb-dependent events.
T38550 1084-1087 JJ denotes Red
T38551 1088-1092 NN denotes text
T38552 1104-1112 VBP denotes indicate
T38553 1093-1096 CC denotes and
T38554 1097-1103 NNS denotes arrows
T38555 1113-1115 NN denotes Rb
T38556 1116-1125 JJ denotes dependent
T38557 1115-1116 HYPH denotes -
T38558 1126-1132 NNS denotes events
T38559 1132-1133 . denotes .
T38560 1133-1228 sentence denotes Black text and arrows indicate events for which there is no direct evidence of Rb involvement.
T38561 1134-1139 JJ denotes Black
T38562 1140-1144 NN denotes text
T38563 1156-1164 VBP denotes indicate
T38564 1145-1148 CC denotes and
T38565 1149-1155 NNS denotes arrows
T38566 1165-1171 NNS denotes events
T38567 1172-1175 IN denotes for
T38568 1188-1190 VBZ denotes is
T38569 1176-1181 WDT denotes which
T38570 1182-1187 EX denotes there
T38571 1191-1193 DT denotes no
T38572 1201-1209 NN denotes evidence
T38573 1194-1200 JJ denotes direct
T38574 1210-1212 IN denotes of
T38575 1213-1215 NN denotes Rb
T38576 1216-1227 NN denotes involvement
T38577 1227-1228 . denotes .
T38578 1228-1420 sentence denotes Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle.
T38579 1229-1231 NN denotes Rb
T38580 1241-1247 VB denotes appear
T38581 1232-1236 VBZ denotes does
T38582 1237-1240 RB denotes not
T38583 1248-1250 TO denotes to
T38584 1251-1257 VB denotes temper
T38585 1258-1261 NN denotes RPC
T38586 1262-1271 NN denotes expansion
T38587 1272-1275 CC denotes and
T38588 1276-1278 VBZ denotes is
T38589 1283-1291 VBN denotes required
T38590 1279-1282 RB denotes not
T38591 1292-1295 IN denotes for
T38592 1296-1311 NN denotes differentiation
T38593 1312-1314 IN denotes of
T38594 1315-1319 NNS denotes RPCs
T38595 1320-1324 IN denotes into
T38596 1325-1329 NNS denotes RTCs
T38597 1329-1331 , denotes ,
T38598 1331-1334 CC denotes but
T38599 1335-1337 VBZ denotes is
T38600 1338-1347 JJ denotes essential
T38601 1348-1350 TO denotes to
T38602 1351-1357 VB denotes couple
T38603 1358-1361 NN denotes RTC
T38604 1362-1367 NN denotes birth
T38605 1368-1370 IN denotes to
T38606 1371-1379 JJ denotes terminal
T38607 1380-1387 NN denotes mitosis
T38608 1387-1389 , denotes ,
T38609 1389-1393 RB denotes thus
T38610 1394-1401 VBG denotes locking
T38611 1402-1406 PRP denotes them
T38612 1407-1410 RB denotes out
T38613 1411-1413 IN denotes of
T38614 1414-1419 NN denotes cycle
T38615 1419-1420 . denotes .
T38616 1420-1466 sentence denotes Rb performs this function by inhibiting E2f1.
T38617 1421-1423 NN denotes Rb
T38618 1424-1432 VBZ denotes performs
T38619 1433-1437 DT denotes this
T38620 1438-1446 NN denotes function
T38621 1447-1449 IN denotes by
T38622 1450-1460 VBG denotes inhibiting
T38623 1461-1465 NN denotes E2f1
T38624 1465-1466 . denotes .
T38625 1466-1555 sentence denotes Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a.
T38626 1467-1469 NN denotes Rb
T38627 1478-1486 VBN denotes required
T38628 1470-1472 VBZ denotes is
T38629 1473-1477 RB denotes also
T38630 1487-1490 IN denotes for
T38631 1491-1494 NN denotes SAC
T38632 1495-1510 NN denotes differentiation
T38633 1510-1512 , denotes ,
T38634 1512-1515 CC denotes and
T38635 1516-1518 IN denotes in
T38636 1530-1534 VBZ denotes acts
T38637 1519-1523 DT denotes this
T38638 1524-1528 NN denotes case
T38639 1528-1530 , denotes ,
T38640 1535-1537 IN denotes by
T38641 1538-1548 VBG denotes inhibiting
T38642 1549-1554 NN denotes E2f3a
T38643 1554-1555 . denotes .
T38644 1555-1653 sentence denotes There is no direct evidence that Rb is required for terminal differentiation of other cell types.
T38645 1556-1561 EX denotes There
T38646 1562-1564 VBZ denotes is
T38647 1565-1567 DT denotes no
T38648 1575-1583 NN denotes evidence
T38649 1568-1574 JJ denotes direct
T38650 1584-1588 IN denotes that
T38651 1595-1603 VBN denotes required
T38652 1589-1591 NN denotes Rb
T38653 1592-1594 VBZ denotes is
T38654 1604-1607 IN denotes for
T38655 1608-1616 JJ denotes terminal
T38656 1617-1632 NN denotes differentiation
T38657 1633-1635 IN denotes of
T38658 1636-1641 JJ denotes other
T38659 1647-1652 NNS denotes types
T38660 1642-1646 NN denotes cell
T38661 1652-1653 . denotes .
T38662 1653-1701 sentence denotes Colour codes and abbreviations as in Figure 1A.
T38663 1654-1660 NN denotes Colour
T38664 1661-1666 NNS denotes codes
T38665 1667-1670 CC denotes and
T38666 1671-1684 NNS denotes abbreviations
T38667 1685-1687 IN denotes as
T38668 1688-1690 IN denotes in
T38669 1691-1697 NN denotes Figure
T38670 1698-1700 NN denotes 1A
T38671 1700-1701 . denotes .
T24729 680-688 JJ denotes specific
T24730 679-680 HYPH denotes -
T24731 703-710 NNS denotes factors
T24732 689-702 NN denotes transcription
T24733 711-715 WDT denotes that
T24734 716-723 VBP denotes promote
T24735 724-739 NN denotes differentiation
T24736 740-741 -LRB- denotes [
T24737 741-743 CD denotes 31
T24814 1741-1742 EX denotes r
T24815 1742-1743 DT denotes o
T24816 1743-1744 VBN denotes u
T24817 1744-1745 sentence denotes g
T24818 1744-1745 NN denotes g
T24821 1745-1746 IN denotes h
T24822 1747-1751 NN denotes E2f3
T24823 1828-1835 VBD denotes rescued
T24824 1756-1767 JJ denotes independent
T24825 1768-1770 IN denotes of
T24717 609-617 JJ denotes skeletal
T24718 618-624 NN denotes muscle
T24719 624-626 , denotes ,
T24720 626-636 NNS denotes adipocytes
T24721 636-638 , denotes ,
T24722 638-641 CC denotes and
T24723 642-646 NN denotes bone
T24724 646-648 , denotes ,
T24725 648-650 PRP denotes it
T24726 657-660 CC denotes and
T24727 661-672 VBZ denotes potentiates
T24728 673-679 NN denotes tissue
T24800 1035-1719 sentence denotes ulates Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulation of
T24801 1035-1036 VBN denotes u
T24802 1036-1037 JJ denotes l
T24803 1037-1038 JJ denotes a
T24804 1038-1713 NN denotes tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati
T24805 1713-1715 VBG denotes on
T24806 1716-1717 RB denotes o
T24807 1717-1718 IN denotes f
T24808 1719-1741 sentence denotes SAC differentiation th
T24809 1719-1722 NN denotes SAC
T24810 1723-1738 NN denotes differentiation
T24811 1738-1739 , denotes
T24812 1739-1741 DT denotes th
T24813 1741-1744 sentence denotes rou
T24819 1745-2011 sentence denotes h E2f3 was independent of its role in controlling division or death: E2f3 deletion rescued Rb KO SAC defects but did not suppress aberrant proliferation or death, whereas E2f1 deletion reversed abnormal proliferation and death but did not rescue SAC differentiation.
T24820 1752-1755 VBD denotes was
R7129 T24609 T24610 nsubj Rb,Controls
R7130 T24611 T24612 compound SAC,Differentiation
R7131 T24612 T24610 dobj Differentiation,Controls
R7132 T24613 T24610 prep through,Controls
R7133 T24614 T24613 pobj E2f3a,through
R7134 T24616 T24617 amod Comprehensive,analysis
R7135 T24617 T24619 nsubj analysis,revealed
R7136 T24618 T24617 compound marker,analysis
R7137 T24620 T24621 mark that,suppress
R7138 T24621 T24619 ccomp suppress,revealed
R7139 T24622 T24621 punct ", ",suppress
R7140 T24623 T24621 prep in,suppress
R7141 T24624 T24625 amod striking,contrast
R7142 T24625 T24623 pobj contrast,in
R7143 T24626 T24625 prep to,contrast
R7144 T24627 T24628 amod other,neurons
R7145 T24628 T24626 pobj neurons,to
R7146 T24629 T24628 amod retinal,neurons
R7147 T24630 T24621 punct ", ",suppress
R7148 T24631 T24632 compound E2f1,deletion
R7149 T24632 T24621 nsubj deletion,suppress
R7150 T24633 T24621 aux did,suppress
R7151 T24634 T24621 neg not,suppress
R7152 T24635 T24621 dobj defects,suppress
R7153 T24636 T24621 prep in,suppress
R7154 T24637 T24638 nmod Rb,KO
R7155 T24638 T24639 nmod KO,SACs
R7156 T24639 T24636 pobj SACs,in
R7157 T24640 T24639 amod cholinergic,SACs
R7158 T24641 T24619 punct .,revealed
R7159 T24643 T24644 advmod Instead,observed
R7160 T24645 T24644 punct ", ",observed
R7161 T24646 T24644 nsubj we,observed
R7162 T24647 T24648 npadvmod E2f1,independent
R7163 T24648 T24650 amod independent,defects
R7164 T24649 T24648 punct -,independent
R7165 T24650 T24644 dobj defects,observed
R7166 T24651 T24650 prep in,defects
R7167 T24652 T24653 det the,synthesis
R7168 T24653 T24651 pobj synthesis,in
R7169 T24654 T24653 cc and,synthesis
R7170 T24655 T24653 conj transport,synthesis
R7171 T24656 T24653 prep of,synthesis
R7172 T24657 T24658 det a,cohort
R7173 T24658 T24656 pobj cohort,of
R7174 T24659 T24658 amod large,cohort
R7175 T24660 T24658 prep of,cohort
R7176 T24661 T24662 compound SAC,proteins
R7177 T24662 T24660 pobj proteins,of
R7178 T24663 T24644 punct .,observed
R7179 T24665 T24666 det These,data
R7180 T24666 T24667 nsubj data,expand
R7181 T24668 T24667 dobj insight,expand
R7182 T24669 T24668 prep into,insight
R7183 T24670 T24671 det the,development
R7184 T24671 T24669 pobj development,into
R7185 T24672 T24671 prep of,development
R7186 T24673 T24674 det these,interneurons
R7187 T24674 T24672 pobj interneurons,of
R7188 T24675 T24674 amod important,interneurons
R7189 T24676 T24667 punct ", ",expand
R7190 T24677 T24667 cc but,expand
R7191 T24678 T24679 advmod more,critically
R7192 T24679 T24680 advmod critically,provide
R7193 T24680 T24667 conj provide,expand
R7194 T24681 T24680 punct ", ",provide
R7195 T24682 T24680 prep to,provide
R7196 T24683 T24684 poss our,knowledge
R7197 T24684 T24682 pobj knowledge,to
R7198 T24685 T24686 det the,evidence
R7199 T24686 T24680 dobj evidence,provide
R7200 T24687 T24686 amod first,evidence
R7201 T24688 T24686 amod unambiguous,evidence
R7202 T24689 T24690 mark that,regulates
R7203 T24690 T24686 acl regulates,evidence
R7204 T24691 T24690 nsubj Rb,regulates
R7205 T24692 T24690 dobj neurogenesis,regulates
R7206 T24693 T24690 prep beyond,regulates
R7207 T24694 T24695 amod terminal,mitosis
R7208 T24695 T24693 pobj mitosis,beyond
R7209 T24696 T24667 punct .,expand
R7210 T24698 T24699 nsubj Rb,binds
R7211 T24700 T24701 amod more,100
R7212 T24701 T24703 nummod 100,factors
R7213 T24702 T24701 quantmod than,100
R7214 T24703 T24699 dobj factors,binds
R7215 T24704 T24705 punct [,43
R7216 T24705 T24699 parataxis 43,binds
R7217 T24706 T24705 punct ],43
R7218 T24707 T24699 punct ", ",binds
R7219 T24708 T24699 cc and,binds
R7220 T24709 T24710 prep in,binds
R7221 T24710 T24699 conj binds,binds
R7222 T24711 T24712 amod several,cells
R7223 T24712 T24709 pobj cells,in
R7224 T24713 T24712 amod non-neuronal,cells
R7225 T24714 T24712 punct ", ",cells
R7226 T24715 T24716 amod such,as
R7227 T24716 T24712 prep as,cells
R7228 T24717 T24718 amod skeletal,muscle
R7229 T24718 T24716 pobj muscle,as
R7230 T24719 T24718 punct ", ",muscle
R7231 T24720 T24718 conj adipocytes,muscle
R7232 T24721 T24720 punct ", ",adipocytes
R7233 T24722 T24720 cc and,adipocytes
R7234 T24723 T24720 conj bone,adipocytes
R7235 T24724 T24710 punct ", ",binds
R7236 T24725 T24710 nsubj it,binds
R7237 T24726 T24710 cc and,binds
R7238 T24727 T24710 conj potentiates,binds
R7239 T24728 T24729 npadvmod tissue,specific
R7240 T24729 T24731 amod specific,factors
R7241 T24730 T24729 punct -,specific
R7242 T24731 T24727 dobj factors,potentiates
R7243 T24732 T24731 compound transcription,factors
R7244 T24733 T24734 dep that,promote
R7245 T24734 T24731 relcl promote,factors
R7246 T24735 T24734 dobj differentiation,promote
R7247 T24736 T24737 punct [,31
R7248 T24737 T24727 parataxis 31,potentiates
R7249 T24738 T24739 punct –,33
R7250 T24739 T24737 prep 33,31
R7251 T24740 T24737 punct ],31
R7252 T24741 T24710 punct .,binds
R7253 T24743 T24744 det The,idea
R7254 T24744 T24745 nsubjpass idea,contested
R7255 T24746 T24747 mark that,promotes
R7256 T24747 T24744 acl promotes,idea
R7257 T24748 T24747 nsubj Rb,promotes
R7258 T24749 T24750 compound muscle,differentiation
R7259 T24750 T24747 dobj differentiation,promotes
R7260 T24751 T24747 prep by,promotes
R7261 T24752 T24751 pcomp potentiating,by
R7262 T24753 T24754 compound Myod1,activity
R7263 T24754 T24752 dobj activity,potentiating
R7264 T24755 T24745 auxpass was,contested
R7265 T24756 T24757 punct [,61
R7266 T24757 T24745 parataxis 61,contested
R7267 T24758 T24757 punct ],61
R7268 T24759 T24745 punct ", ",contested
R7269 T24760 T24745 cc and,contested
R7270 T24761 T24762 amod other,mechanisms
R7271 T24762 T24763 nsubj mechanisms,proposed
R7307 T24822 T24821 pobj E2f3,h
R7308 T24824 T24820 acomp independent,was
R7309 T24825 T24824 prep of,independent
R7310 T24826 T24827 poss its,role
R7311 T24827 T24825 pobj role,of
R7312 T24828 T24827 prep in,role
R7313 T24829 T24828 pcomp controlling,in
R7314 T24830 T24829 dobj division,controlling
R7315 T24831 T24830 cc or,division
R7316 T24832 T24830 conj death,division
R7317 T24833 T24823 punct : ,rescued
R7318 T24834 T24835 compound E2f3,deletion
R7319 T24835 T24823 nsubj deletion,rescued
R7320 T24836 T24837 compound Rb,KO
R7321 T24837 T24838 compound KO,defects
R7322 T24838 T24823 dobj defects,rescued
R7323 T24839 T24838 compound SAC,defects
R7324 T24840 T24823 cc but,rescued
R7325 T24841 T24842 aux did,suppress
R7326 T24842 T24823 conj suppress,rescued
R7327 T24843 T24842 neg not,suppress
R7328 T24844 T24845 amod aberrant,proliferation
R7329 T24845 T24842 dobj proliferation,suppress
R7330 T24846 T24845 cc or,proliferation
R7331 T24847 T24845 conj death,proliferation
R7332 T24848 T24842 punct ", ",suppress
R7333 T24849 T24850 mark whereas,reversed
R7334 T24850 T24842 advcl reversed,suppress
R7335 T24851 T24852 compound E2f1,deletion
R7336 T24852 T24850 nsubj deletion,reversed
R7337 T24853 T24854 amod abnormal,proliferation
R7338 T24854 T24850 dobj proliferation,reversed
R7339 T24855 T24854 cc and,proliferation
R7340 T24856 T24854 conj death,proliferation
R7341 T24857 T24850 cc but,reversed
R7342 T24858 T24859 aux did,rescue
R7343 T24859 T24850 conj rescue,reversed
R7344 T24860 T24859 neg not,rescue
R7345 T24861 T24862 compound SAC,differentiation
R7346 T24862 T24859 dobj differentiation,rescue
R7347 T24863 T24823 punct .,rescued
R7348 T24865 T24866 amod Double,labelling
R7349 T24866 T24867 nsubj labelling,confirmed
R7350 T24868 T24869 mark that,reversed
R7351 T24869 T24867 ccomp reversed,confirmed
R7352 T24870 T24871 nmod E2f1,deletion
R7353 T24871 T24869 nsubj deletion,reversed
R7354 T24872 T24870 cc but,E2f1
R7355 T24873 T24872 neg not,but
R7356 T24874 T24870 conj E2f3,E2f1
R7357 T24875 T24876 compound Rb,KO
R7358 T24876 T24877 compound KO,SAC
R7359 T24877 T24878 compound SAC,division
R7360 T24878 T24869 dobj division,reversed
R7361 T24879 T24867 punct .,confirmed
R7362 T24881 T24882 advmod Moreover,reversed
R7363 T24883 T24882 punct ", ",reversed
R7364 T24884 T24882 csubj deleting,reversed
R7365 T24885 T24884 dobj E2f1,deleting
R7366 T24886 T24885 punct ", ",E2f1
R7367 T24887 T24885 cc but,E2f1
R7368 T24888 T24887 neg not,but
R7369 T24889 T24885 conj E2f3,E2f1
R7370 T24890 T24882 punct ", ",reversed
R7371 T24891 T24892 amod deregulated,expression
R7372 T24892 T24882 dobj expression,reversed
R7373 T24893 T24892 prep of,expression
R7374 T24894 T24895 compound cell,cycle
R7375 T24895 T24893 pobj cycle,of
R7376 T24896 T24895 cc and,cycle
R7377 T24897 T24898 amod apoptotic,genes
R7378 T24898 T24895 conj genes,cycle
R7379 T24899 T24882 prep in,reversed
R7380 T24900 T24901 det the,retina
R7381 T24901 T24899 pobj retina,in
R7382 T24902 T24903 compound Rb,KO
R7383 T24903 T24901 compound KO,retina
R7384 T24904 T24882 punct .,reversed
R7385 T24906 T24907 nsubjpass E2f3,expressed
R7386 T24908 T24907 auxpass is,expressed
R7387 T24909 T24907 prep in,expressed
R7388 T24910 T24911 det a,subset
R7389 T24911 T24909 pobj subset,in
R7400 T24922 T24920 dobj defects,drives
R7402 T24924 T24926 npadvmod cycle,independent
R7403 T24925 T24924 punct -,cycle
R7404 T24926 T24922 amod independent,defects
R7405 T24927 T24926 punct –,independent
R7406 T24928 T24920 prep in,drives
R7407 T24929 T24930 compound Rb,KO
R7408 T24930 T24931 compound KO,neurons
R7409 T24931 T24928 pobj neurons,in
R7410 T24932 T24931 compound forebrain,neurons
R7411 T24933 T24934 punct [,53
R7412 T24934 T24920 parataxis 53,drives
R7413 T24935 T24934 punct ],53
R7414 T24936 T24907 punct .,expressed
R7415 T24938 T24939 advmod Thus,is
R7416 T24940 T24939 punct ", ",is
R7417 T24941 T24942 compound E2f3,inhibition
R7418 T24942 T24939 nsubj inhibition,is
R7419 T24943 T24944 det the,first
R7420 T24944 T24939 attr first,is
R7421 T24945 T24939 punct ", ",is
R7422 T24946 T24939 cc and,is
R7423 T24947 T24948 aux may,be
R7424 T24948 T24939 conj be,is
R7425 T24949 T24950 det the,only
R7426 T24950 T24948 attr only,be
R7427 T24951 T24948 punct ", ",be
R7428 T24952 T24948 conj mechanism,be
R7429 T24953 T24954 prep by,participates
R7430 T24954 T24952 ccomp participates,mechanism
R7431 T24955 T24953 pobj which,by
R7432 T24956 T24954 nsubj Rb,participates
R7433 T24957 T24954 advmod directly,participates
R7434 T24958 T24954 prep in,participates
R7435 T24959 T24960 amod neuronal,differentiation
R7436 T24960 T24958 pobj differentiation,in
R7437 T24961 T24939 punct .,is
R7438 T24963 T24964 aux To,dissect
R7439 T24964 T24966 advcl dissect,determined
R7440 T24965 T24964 advmod further,dissect
R7441 T24967 T24968 det the,mechanism
R7442 T24968 T24964 dobj mechanism,dissect
R7443 T24969 T24968 prep of,mechanism
R7444 T24970 T24969 pobj action,of
R7445 T24971 T24968 prep of,mechanism
R7446 T24972 T24971 pobj Rb,of
R7447 T24973 T24968 prep in,mechanism
R7448 T24974 T24973 pobj SACs,in
R7449 T24975 T24966 nsubj we,determined
R7450 T24976 T24977 det the,isoform
R7451 T24977 T24966 dobj isoform,determined
R7452 T24978 T24977 compound E2f3,isoform
R7453 T24979 T24980 nsubj it,targets
R7454 T24980 T24977 advcl targets,isoform
R7455 T24981 T24982 aux to,promote
R7456 T24982 T24980 advcl promote,targets
R7457 T24983 T24982 dobj differentiation,promote
R7458 T24984 T24966 punct .,determined
R7459 T24986 T24987 nsubj E2f3b,was
R7460 T24988 T24989 det the,candidate
R7461 T24989 T24987 attr candidate,was
R7462 T24990 T24989 amod primary,candidate
R7463 T24991 T24987 punct ", ",was
R7464 T24992 T24993 mark since,collaborate
R7465 T24993 T24987 advcl collaborate,was
R7466 T24994 T24993 nsubj Rb,collaborate
R7467 T24995 T24994 cc and,Rb
R7468 T24996 T24994 conj E2f3b,Rb
R7469 T24997 T24998 aux to,repress
R7470 T24998 T24993 advcl repress,collaborate
R7471 T24999 T24998 dobj targets,repress
R7472 T25000 T24998 prep in,repress
R7473 T25001 T25002 amod quiescent,cells
R7474 T25002 T25000 pobj cells,in
R7475 T25003 T25004 advmod in,vitro
R7476 T25004 T24998 advmod vitro,repress
R7477 T25005 T25006 punct [,19
R7478 T25006 T24998 parataxis 19,repress
R7479 T25007 T25006 punct ],19
R7480 T25008 T24987 punct .,was
R7481 T25010 T25011 advmod However,made
R7482 T25012 T25011 punct ", ",made
R7483 T25013 T25011 prep in,made
R7484 T25014 T25015 det the,work
R7485 T25015 T25013 pobj work,in
R7486 T25016 T25015 amod first,work
R7487 T25017 T25018 prep to,examine
R7488 T25018 T25015 advcl examine,work
R7489 T25019 T25020 poss our,knowledge
R7490 T25020 T25017 pobj knowledge,to
R7491 T25021 T25018 aux to,examine
R7492 T25022 T25023 det the,function
R7493 T25023 T25018 dobj function,examine
R7494 T25024 T25023 prep of,function
R7495 T25025 T25026 det any,isoform
R7496 T25026 T25024 pobj isoform,of
R7497 T25027 T25028 compound E2f,protein
R7498 T25028 T25026 compound protein,isoform
R7499 T25029 T25030 advmod in,vivo
R7500 T25030 T25018 advmod vivo,examine
R7501 T25031 T25011 punct ", ",made
R7502 T25032 T25011 nsubj we,made
R7503 T25033 T25034 det the,observation
R7504 T25034 T25011 dobj observation,made
R7505 T25035 T25034 amod surprising,observation
R7506 T25036 T25037 mark that,regulates
R7507 T25037 T25034 acl regulates,observation
R7508 T25038 T25037 nsubj Rb,regulates
R7509 T25039 T25040 compound SAC,differentiation
R7510 T25040 T25037 dobj differentiation,regulates
R7511 T25041 T25037 prep through,regulates
R7512 T25042 T25041 pobj E2f3a,through
R7513 T25043 T25044 punct (,Figure
R7514 T25044 T25037 parataxis Figure,regulates
R7515 T25045 T25044 nummod 8,Figure
R7516 T25046 T25044 punct ),Figure
R7517 T25047 T25011 punct .,made
R7518 T25049 T25050 advmod Formally,exclude
R7519 T25051 T25050 punct ", ",exclude
R7520 T25052 T25050 nsubj we,exclude
R7521 T25053 T25050 aux can,exclude
R7522 T25054 T25050 neg not,exclude
R7523 T25055 T25056 det the,possibility
R7524 T25056 T25050 dobj possibility,exclude
R7525 T25057 T25058 mark that,rescue
R7526 T25058 T25056 acl rescue,possibility
R7527 T25059 T25058 csubj deleting,rescue
R7528 T25060 T25059 dobj E2f3b,deleting
R7529 T25061 T25058 aux might,rescue
R7530 T25062 T25058 advmod also,rescue
R7531 T25063 T25064 compound SAC,differentiation
R7532 T25064 T25058 dobj differentiation,rescue
R7533 T25065 T25050 punct ", ",exclude
R7534 T25066 T25050 cc but,exclude
R7535 T25067 T25068 amod definitive,proof
R7536 T25068 T25069 nsubj proof,require
R7537 T25069 T25050 conj require,exclude
R7538 T25070 T25069 aux will,require
R7539 T25071 T25069 dobj analysis,require
R7540 T25072 T25071 prep of,analysis
R7541 T25073 T25074 npadvmod E2f3b,null
R7542 T25074 T25075 amod null,mice
R7543 T25075 T25072 pobj mice,of
R7544 T25076 T25069 punct .,require
R7545 T25078 T25079 advmod Nevertheless,prove
R7546 T25080 T25079 punct ", ",prove
R7547 T25081 T25082 poss our,data
R7548 T25082 T25079 nsubj data,prove
R7549 T25083 T25084 mark that,regulates
R7550 T25084 T25079 ccomp regulates,prove
R7551 T25085 T25084 nsubj Rb,regulates
R7552 T25086 T25084 advmod definitely,regulates
R7553 T25087 T25088 compound SAC,differentiation
R7554 T25088 T25084 dobj differentiation,regulates
R7555 T25089 T25084 prep through,regulates
R7556 T25090 T25091 det the,isoform
R7557 T25091 T25089 pobj isoform,through
R7558 T25092 T25091 amod activating,isoform
R7559 T25093 T25091 compound E2f3,isoform
R7560 T25094 T25079 punct .,prove
R11654 T38541 T38542 nsubj Rb,Regulates
R11655 T38543 T38544 amod Distinct,Processes
R11656 T38544 T38542 dobj Processes,Regulates
R11657 T38545 T38542 prep through,Regulates
R11658 T38546 T38545 pobj E2f1,through
R11659 T38547 T38546 cc and,E2f1
R11660 T38548 T38546 conj E2f3a,E2f1
R11661 T38550 T38551 amod Red,text
R11662 T38551 T38552 nsubj text,indicate
R11663 T38553 T38551 cc and,text
R11664 T38554 T38551 conj arrows,text
R11665 T38555 T38556 npadvmod Rb,dependent
R11666 T38556 T38558 amod dependent,events
R11667 T38557 T38556 punct -,dependent
R11668 T38558 T38552 dobj events,indicate
R11669 T38559 T38552 punct .,indicate
R11670 T38561 T38562 amod Black,text
R11671 T38562 T38563 nsubj text,indicate
R11672 T38564 T38562 cc and,text
R11673 T38565 T38562 conj arrows,text
R11674 T38566 T38563 dobj events,indicate
R11675 T38567 T38568 prep for,is
R11676 T38568 T38566 relcl is,events
R11677 T38569 T38567 pobj which,for
R11678 T38570 T38568 expl there,is
R11679 T38571 T38572 det no,evidence
R11680 T38572 T38568 attr evidence,is
R11681 T38573 T38572 amod direct,evidence
R11682 T38574 T38572 prep of,evidence
R11683 T38575 T38576 compound Rb,involvement
R11684 T38576 T38574 pobj involvement,of
R11685 T38577 T38563 punct .,indicate
R11686 T38579 T38580 nsubj Rb,appear
R11687 T38581 T38580 aux does,appear
R11688 T38582 T38580 neg not,appear
R11689 T38583 T38584 aux to,temper
R11690 T38584 T38580 xcomp temper,appear
R11691 T38585 T38586 compound RPC,expansion
R11692 T38586 T38584 dobj expansion,temper
R11693 T38587 T38580 cc and,appear
R11694 T38588 T38589 auxpass is,required
R11695 T38589 T38580 conj required,appear
R11696 T38590 T38589 neg not,required
R11697 T38591 T38589 prep for,required
R11698 T38592 T38591 pobj differentiation,for
R11699 T38593 T38592 prep of,differentiation
R11700 T38594 T38593 pobj RPCs,of
R11701 T38595 T38592 prep into,differentiation
R11702 T38596 T38595 pobj RTCs,into
R11703 T38597 T38589 punct ", ",required
R11704 T38598 T38589 cc but,required
R11705 T38599 T38589 conj is,required
R11706 T38600 T38599 acomp essential,is
R11707 T38601 T38602 aux to,couple
R11708 T38602 T38599 advcl couple,is
R11709 T38603 T38604 compound RTC,birth
R11710 T38604 T38602 dobj birth,couple
R11711 T38605 T38602 prep to,couple
R11712 T38606 T38607 amod terminal,mitosis
R11713 T38607 T38605 pobj mitosis,to
R11714 T38608 T38602 punct ", ",couple
R11715 T38609 T38610 advmod thus,locking
R11716 T38610 T38602 advcl locking,couple
R11717 T38611 T38610 dobj them,locking
R11718 T38612 T38613 advmod out,of
R11719 T38613 T38610 oprd of,locking
R11720 T38614 T38613 pobj cycle,of
R11721 T38615 T38580 punct .,appear
R11722 T38617 T38618 nsubj Rb,performs
R11723 T38619 T38620 det this,function
R11724 T38620 T38618 dobj function,performs
R11725 T38621 T38618 prep by,performs
R11726 T38622 T38621 pcomp inhibiting,by
R11727 T38623 T38622 dobj E2f1,inhibiting
R11728 T38624 T38618 punct .,performs
R11729 T38626 T38627 nsubjpass Rb,required
R11730 T38628 T38627 auxpass is,required
R11731 T38629 T38627 advmod also,required
R11732 T38630 T38627 prep for,required
R11733 T38631 T38632 compound SAC,differentiation
R11734 T38632 T38630 pobj differentiation,for
R11735 T38633 T38627 punct ", ",required
R11736 T38634 T38627 cc and,required
R11737 T38635 T38636 prep in,acts
R11738 T38636 T38627 conj acts,required
R11739 T38637 T38638 det this,case
R11740 T38638 T38635 pobj case,in
R11741 T38639 T38636 punct ", ",acts
R11742 T38640 T38636 prep by,acts
R11743 T38641 T38640 pcomp inhibiting,by
R11744 T38642 T38641 dobj E2f3a,inhibiting
R11745 T38643 T38627 punct .,required
R11746 T38645 T38646 expl There,is
R11747 T38647 T38648 det no,evidence
R11748 T38648 T38646 attr evidence,is
R11749 T38649 T38648 amod direct,evidence
R11750 T38650 T38651 mark that,required
R11751 T38651 T38648 acl required,evidence
R11752 T38652 T38651 nsubjpass Rb,required
R11753 T38653 T38651 auxpass is,required
R11754 T38654 T38651 prep for,required
R11755 T38655 T38656 amod terminal,differentiation
R11756 T38656 T38654 pobj differentiation,for
R11757 T38657 T38656 prep of,differentiation
R11758 T38658 T38659 amod other,types
R11759 T38659 T38657 pobj types,of
R11760 T38660 T38659 compound cell,types
R11761 T38661 T38646 punct .,is
R11762 T38663 T38664 compound Colour,codes
R11763 T38665 T38664 cc and,codes
R11764 T38666 T38664 conj abbreviations,codes
R11765 T38667 T38664 prep as,codes
R11766 T38668 T38667 prep in,as
R11767 T38669 T38670 compound Figure,1A
R11768 T38670 T38668 pobj 1A,in
R11769 T38671 T38664 punct .,codes
R7272 T24763 T24745 conj proposed,contested
R7273 T24764 T24765 punct [,63
R7274 T24765 T24763 parataxis 63,proposed
R7275 T24766 T24765 nummod 62,63
R7276 T24767 T24765 punct ",",63
R7277 T24768 T24765 punct ],63
R7278 T24769 T24763 punct ", ",proposed
R7279 T24770 T24771 cc but,involving
R7280 T24771 T24763 dep involving,proposed
R7281 T24772 T24771 neg not,involving
R7282 T24773 T24774 compound E2f,repression
R7283 T24774 T24771 dobj repression,involving
R7284 T24775 T24763 punct .,proposed
R7285 T24777 T24778 advmod Strikingly,discovered
R7286 T24779 T24778 punct ", ",discovered
R7287 T24780 T24778 advmod however,discovered
R7288 T24781 T24778 punct ", ",discovered
R7289 T24782 T24778 nsubj we,discovered
R7290 T24783 T24784 mark that,promotes
R7291 T24784 T24778 ccomp promotes,discovered
R7292 T24785 T24784 nsubj Rb,promotes
R7293 T24786 T24787 compound SAC,differentiation
R7294 T24787 T24784 dobj differentiation,promotes
R7295 T24788 T24784 prep through,promotes
R7296 T24789 T24788 pobj E2f3,through
R7297 T24790 T24791 punct (,Figure
R7298 T24791 T24784 parataxis Figure,promotes
R7299 T24792 T24791 nummod 8,Figure
R7300 T24793 T24791 punct ),Figure
R7301 T24794 T24778 punct .,discovered
R7302 T24803 T24804 amod a,"tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati"
R7303 T24806 T24807 advmod o,f
R7304 T24807 T24805 oprd f,on
R7305 T24809 T24810 compound SAC,differentiation
R7306 T24820 T24823 ccomp was,rescued
R7390 T24912 T24911 prep of,subset
R7391 T24913 T24914 compound CNS,neurons
R7392 T24914 T24912 pobj neurons,of
R7393 T24915 T24916 punct (,work
R7394 T24916 T24907 parataxis work,expressed
R7395 T24917 T24916 det this,work
R7396 T24918 T24916 punct ),work
R7397 T24919 T24907 cc and,expressed
R7398 T24920 T24907 conj drives,expressed
R7399 T24921 T24922 amod specific,defects
R7401 T24923 T24924 compound cell,cycle

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T24511 225-229 PR_EXT:000006852 denotes E2f1
T24512 306-314 CHEBI_PR_EXT:protein denotes proteins
T24513 382-394 CL:0000099 denotes interneurons
T24514 478-480 PR_EXT:000013773 denotes Rb
T24515 481-490 GO:0065007 denotes regulates
T24516 491-503 GO:0022008 denotes neurogenesis
T24517 520-527 GO:0007067 denotes mitosis
T24518 529-531 PR_EXT:000013773 denotes Rb
T24519 532-537 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T24520 585-593 CL:0000540 denotes neuronal
T24521 594-599 CL_GO_EXT:cell denotes cells
T24522 609-624 UBERON_EXT:skeletal_muscle_organ_or_tissue denotes skeletal muscle
T24523 626-636 CL:0000136 denotes adipocytes
T24524 642-646 UBERON_EXT:bone_element_or_tissue denotes bone
T24525 651-656 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T24526 673-679 UBERON:0000479 denotes tissue
T24527 689-702 GO_EXT:transcription denotes transcription
T24528 689-710 GO_EXT:transcription_factor denotes transcription factors
T24529 724-739 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24530 763-765 PR_EXT:000013773 denotes Rb
T24531 775-781 UBERON_EXT:muscle_structure_or_tissue denotes muscle
T24532 782-797 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24533 814-819 PR_EXT:000010875 denotes Myod1
T24534 906-909 PR_EXT:E2F denotes E2f
T24535 962-964 PR_EXT:000013773 denotes Rb
T24536 978-993 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24537 1002-1006 PR_EXT:000006854 denotes E2f3
T24538 1029-1031 PR_EXT:000013773 denotes Rb
T24539 1038-1713 GO:0007067 denotes tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati
T24540 1723-1738 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24541 1747-1751 PR_EXT:000006854 denotes E2f3
T24542 1783-1794 GO:0065007 denotes controlling
T24543 1807-1812 GO:0016265 denotes death
T24544 1814-1818 PR_EXT:000006854 denotes E2f3
T24545 1819-1827 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T24546 1828-1835 SO_EXT:sequence_rescue_process denotes rescued
T24547 1836-1838 PR_EXT:000013773 denotes Rb
T24548 1884-1897 GO:0008283 denotes proliferation
T24549 1901-1906 GO:0016265 denotes death
T24550 1916-1920 PR_EXT:000006852 denotes E2f1
T24551 1921-1929 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T24552 1948-1961 GO:0008283 denotes proliferation
T24553 1966-1971 GO:0016265 denotes death
T24554 1984-1990 SO_EXT:sequence_rescue_process denotes rescue
T24555 1995-2010 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24556 2019-2028 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labelling
T24557 2044-2048 PR_EXT:000006852 denotes E2f1
T24558 2057-2061 PR_EXT:000006854 denotes E2f3
T24559 2062-2070 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T24560 2080-2082 PR_EXT:000013773 denotes Rb
T24561 2110-2118 SO_EXT:sequence_deletion_process denotes deleting
T24562 2119-2123 PR_EXT:000006852 denotes E2f1
T24563 2133-2137 PR_EXT:000006854 denotes E2f3
T24564 2150-2159 GO:0065007 denotes regulated
T24565 2160-2170 GO:0010467 denotes expression
T24566 2174-2178 CL_GO_EXT:cell denotes cell
T24567 2174-2184 GO:0007049 denotes cell cycle
T24568 2189-2198 GO_PATO_EXT:apoptotic_process_or_quality denotes apoptotic
T24569 2199-2204 SO_EXT:0000704 denotes genes
T24570 2212-2214 PR_EXT:000013773 denotes Rb
T24571 2218-2224 UBERON:0000966 denotes retina
T24572 2226-2230 PR_EXT:000006854 denotes E2f3
T24573 2234-2243 GO:0010467 denotes expressed
T24574 2259-2262 UBERON:0001017 denotes CNS
T24575 2259-2270 CL:0000117 denotes CNS neurons
T24576 2303-2307 CL_GO_EXT:cell denotes cell
T24577 2303-2313 GO:0007049 denotes cell-cycle
T24578 2337-2339 PR_EXT:000013773 denotes Rb
T24579 2343-2352 UBERON:0001890 denotes forebrain
T24580 2343-2360 CL:0012001 denotes forebrain neurons
T24581 2373-2377 PR_EXT:000006854 denotes E2f3
T24582 2443-2445 PR_EXT:000013773 denotes Rb
T24583 2471-2479 CL:0000540 denotes neuronal
T24584 2480-2495 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24585 2543-2545 PR_EXT:000013773 denotes Rb
T24586 2572-2576 PR_EXT:000006854 denotes E2f3
T24587 2577-2584 SO_EXT:0001060 denotes isoform
T24588 2607-2622 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24589 2663-2665 PR_EXT:000013773 denotes Rb
T24590 2710-2719 GO:0044838 denotes quiescent
T24591 2720-2725 CL_GO_EXT:cell denotes cells
T24592 2816-2819 PR_EXT:E2F denotes E2f
T24593 2820-2827 CHEBI_PR_EXT:protein denotes protein
T24594 2828-2835 SO_EXT:0001060 denotes isoform
T24595 2885-2887 PR_EXT:000013773 denotes Rb
T24596 2888-2897 GO:0065007 denotes regulates
T24597 2902-2917 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24598 2926-2931 PR_EXT:000028775 denotes E2f3a
T24599 2993-3001 SO_EXT:sequence_deletion_process denotes deleting
T24600 3019-3025 SO_EXT:sequence_rescue_process denotes rescue
T24601 3030-3045 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24602 3099-3103 SO_EXT:sequence_nullness denotes null
T24603 3104-3108 NCBITaxon:10088 denotes mice
T24604 3144-3146 PR_EXT:000013773 denotes Rb
T24605 3158-3167 GO:0065007 denotes regulates
T24606 3172-3187 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T24607 3211-3215 PR_EXT:000006854 denotes E2f3
T24608 3216-3223 SO_EXT:0001060 denotes isoform
T38522 1029-1031 PR_EXT:000013773 denotes Rb
T38523 1032-1041 GO:0065007 denotes Regulates
T38524 1069-1073 PR_EXT:000006852 denotes E2f1
T38525 1078-1083 PR_EXT:000028775 denotes E2f3a
T38526 1113-1115 PR_EXT:000013773 denotes Rb
T38527 1213-1215 PR_EXT:000013773 denotes Rb
T38528 1229-1231 PR_EXT:000013773 denotes Rb
T38529 1258-1261 CL:0002672 denotes RPC
T38530 1296-1311 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T38531 1315-1319 CL:0002672 denotes RPCs
T38532 1380-1387 GO:0007067 denotes mitosis
T38533 1421-1423 PR_EXT:000013773 denotes Rb
T38534 1461-1465 PR_EXT:000006852 denotes E2f1
T38535 1467-1469 PR_EXT:000013773 denotes Rb
T38536 1495-1510 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T38537 1549-1554 PR_EXT:000028775 denotes E2f3a
T38538 1589-1591 PR_EXT:000013773 denotes Rb
T38539 1617-1632 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T38540 1642-1646 CL_GO_EXT:cell denotes cell
T24500 0-2 PR_EXT:000013773 denotes Rb
T24501 3-11 GO:0065007 denotes Controls
T24502 16-31 GO_RO_EXT:developmental_differentiation_process denotes Differentiation
T24503 40-45 PR_EXT:000028775 denotes E2f3a
T24504 60-66 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T24505 121-128 UBERON:0000966 denotes retinal
T24506 129-136 CL:0000540 denotes neurons
T24507 138-142 PR_EXT:000006852 denotes E2f1
T24508 143-151 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T24509 180-182 PR_EXT:000013773 denotes Rb
T24510 186-197 CHEBI:15355 denotes cholinergic

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T24468 2133-2137 PR:000006854 denotes E2f3
T24469 2150-2159 GO:0065007 denotes regulated
T24470 2160-2170 GO:0010467 denotes expression
T24471 2174-2184 GO:0007049 denotes cell cycle
T24472 2199-2204 SO:0000704 denotes genes
T24473 2212-2214 PR:000013773 denotes Rb
T24474 2218-2224 UBERON:0000966 denotes retina
T24475 2226-2230 PR:000006854 denotes E2f3
T24444 585-593 CL:0000540 denotes neuronal
T24445 609-617 UBERON:0004288 denotes skeletal
T24446 626-636 CL:0000136 denotes adipocytes
T24447 673-679 UBERON:0000479 denotes tissue
T24448 763-765 PR:000013773 denotes Rb
T24449 814-819 PR:000010875 denotes Myod1
T24450 962-964 PR:000013773 denotes Rb
T24451 1002-1006 PR:000006854 denotes E2f3
T24452 1029-1031 PR:000013773 denotes Rb
T24453 1038-1713 GO:0007067 denotes tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati
T24454 1747-1751 PR:000006854 denotes E2f3
T24455 1783-1794 GO:0065007 denotes controlling
T24456 1807-1812 GO:0016265 denotes death
T24457 1814-1818 PR:000006854 denotes E2f3
T24458 1836-1838 PR:000013773 denotes Rb
T24459 1884-1897 GO:0008283 denotes proliferation
T24460 1901-1906 GO:0016265 denotes death
T24461 1916-1920 PR:000006852 denotes E2f1
T24462 1948-1961 GO:0008283 denotes proliferation
T24463 1966-1971 GO:0016265 denotes death
T24464 2044-2048 PR:000006852 denotes E2f1
T24465 2057-2061 PR:000006854 denotes E2f3
T24466 2080-2082 PR:000013773 denotes Rb
T24467 2119-2123 PR:000006852 denotes E2f1
T24476 2234-2243 GO:0010467 denotes expressed
T24477 2259-2262 UBERON:0001017 denotes CNS
T24478 2259-2270 CL:0000117 denotes CNS neurons
T24479 2303-2313 GO:0007049 denotes cell-cycle
T24480 2337-2339 PR:000013773 denotes Rb
T24481 2343-2352 UBERON:0001890 denotes forebrain
T24482 2343-2360 CL:0012001 denotes forebrain neurons
T24483 2373-2377 PR:000006854 denotes E2f3
T24484 2443-2445 PR:000013773 denotes Rb
T24485 2471-2479 CL:0000540 denotes neuronal
T24486 2543-2545 PR:000013773 denotes Rb
T24487 2572-2576 PR:000006854 denotes E2f3
T24488 2577-2584 SO:0001060 denotes isoform
T24489 2663-2665 PR:000013773 denotes Rb
T24490 2710-2719 GO:0044838 denotes quiescent
T24491 2828-2835 SO:0001060 denotes isoform
T24492 2885-2887 PR:000013773 denotes Rb
T24493 2888-2897 GO:0065007 denotes regulates
T24494 2926-2931 PR:000028775 denotes E2f3a
T24495 3104-3108 NCBITaxon:10088 denotes mice
T24496 3144-3146 PR:000013773 denotes Rb
T24497 3158-3167 GO:0065007 denotes regulates
T24498 3211-3215 PR:000006854 denotes E2f3
T24499 3216-3223 SO:0001060 denotes isoform
T38511 1113-1115 PR:000013773 denotes Rb
T38507 1029-1031 PR:000013773 denotes Rb
T38508 1032-1041 GO:0065007 denotes Regulates
T38509 1069-1073 PR:000006852 denotes E2f1
T38510 1078-1083 PR:000028775 denotes E2f3a
T38512 1213-1215 PR:000013773 denotes Rb
T38513 1229-1231 PR:000013773 denotes Rb
T38514 1258-1261 CL:0002672 denotes RPC
T38515 1315-1319 CL:0002672 denotes RPCs
T38516 1380-1387 GO:0007067 denotes mitosis
T38517 1421-1423 PR:000013773 denotes Rb
T38518 1461-1465 PR:000006852 denotes E2f1
T38519 1467-1469 PR:000013773 denotes Rb
T38520 1549-1554 PR:000028775 denotes E2f3a
T38521 1589-1591 PR:000013773 denotes Rb
T24429 0-2 PR:000013773 denotes Rb
T24430 3-11 GO:0065007 denotes Controls
T24431 40-45 PR:000028775 denotes E2f3a
T24432 121-128 UBERON:0000966 denotes retinal
T24433 129-136 CL:0000540 denotes neurons
T24434 138-142 PR:000006852 denotes E2f1
T24435 180-182 PR:000013773 denotes Rb
T24436 186-197 CHEBI:15355 denotes cholinergic
T24437 225-229 PR:000006852 denotes E2f1
T24438 382-394 CL:0000099 denotes interneurons
T24439 478-480 PR:000013773 denotes Rb
T24440 481-490 GO:0065007 denotes regulates
T24441 491-503 GO:0022008 denotes neurogenesis
T24442 520-527 GO:0007067 denotes mitosis
T24443 529-531 PR:000013773 denotes Rb

2_test

Id Subject Object Predicate Lexical cue
17608565-11447760-84869019 561-563 11447760 denotes 43
17608565-8381715-84869020 741-743 8381715 denotes 31
17608565-11545733-84869020 741-743 11545733 denotes 31
17608565-8946919-84869020 741-743 8946919 denotes 31
17608565-10601020-84869021 844-846 10601020 denotes 61
17608565-11684023-84869022 880-882 11684023 denotes 62
17608565-11034201-84869023 883-885 11034201 denotes 63
17608565-15175242-84869024 2736-2738 15175242 denotes 19
T97762 561-563 11447760 denotes 43
T62413 741-743 8381715 denotes 31
T83034 741-743 11545733 denotes 31
T20471 741-743 8946919 denotes 31
T83077 844-846 10601020 denotes 61
T32657 880-882 11684023 denotes 62
T9102 883-885 11034201 denotes 63
T68445 2736-2738 15175242 denotes 19