Id |
Subject |
Object |
Predicate |
Lexical cue |
T24609 |
0-2 |
NN |
denotes |
Rb |
T24610 |
3-11 |
VBZ |
denotes |
Controls |
T24611 |
12-15 |
NN |
denotes |
SAC |
T24612 |
16-31 |
NN |
denotes |
Differentiation |
T24613 |
32-39 |
IN |
denotes |
through |
T24614 |
40-45 |
NN |
denotes |
E2f3a |
T24615 |
45-203 |
sentence |
denotes |
Comprehensive marker analysis revealed that, in striking contrast to other retinal neurons, E2f1 deletion did not suppress defects in Rb KO cholinergic SACs. |
T24616 |
46-59 |
JJ |
denotes |
Comprehensive |
T24617 |
67-75 |
NN |
denotes |
analysis |
T24618 |
60-66 |
NN |
denotes |
marker |
T24619 |
76-84 |
VBD |
denotes |
revealed |
T24620 |
85-89 |
IN |
denotes |
that |
T24621 |
160-168 |
VB |
denotes |
suppress |
T24622 |
89-91 |
, |
denotes |
, |
T24623 |
91-93 |
IN |
denotes |
in |
T24624 |
94-102 |
JJ |
denotes |
striking |
T24625 |
103-111 |
NN |
denotes |
contrast |
T24626 |
112-114 |
IN |
denotes |
to |
T24627 |
115-120 |
JJ |
denotes |
other |
T24628 |
129-136 |
NNS |
denotes |
neurons |
T24629 |
121-128 |
JJ |
denotes |
retinal |
T24630 |
136-138 |
, |
denotes |
, |
T24631 |
138-142 |
NN |
denotes |
E2f1 |
T24632 |
143-151 |
NN |
denotes |
deletion |
T24633 |
152-155 |
VBD |
denotes |
did |
T24634 |
156-159 |
RB |
denotes |
not |
T24635 |
169-176 |
NNS |
denotes |
defects |
T24636 |
177-179 |
IN |
denotes |
in |
T24637 |
180-182 |
NN |
denotes |
Rb |
T24638 |
183-185 |
NN |
denotes |
KO |
T24639 |
198-202 |
NNS |
denotes |
SACs |
T24640 |
186-197 |
JJ |
denotes |
cholinergic |
T24641 |
202-203 |
. |
denotes |
. |
T24642 |
203-315 |
sentence |
denotes |
Instead, we observed E2f1-independent defects in the synthesis and transport of a large cohort of SAC proteins. |
T24643 |
204-211 |
RB |
denotes |
Instead |
T24644 |
216-224 |
VBD |
denotes |
observed |
T24645 |
211-213 |
, |
denotes |
, |
T24646 |
213-215 |
PRP |
denotes |
we |
T24647 |
225-229 |
NN |
denotes |
E2f1 |
T24648 |
230-241 |
JJ |
denotes |
independent |
T24649 |
229-230 |
HYPH |
denotes |
- |
T24650 |
242-249 |
NNS |
denotes |
defects |
T24651 |
250-252 |
IN |
denotes |
in |
T24652 |
253-256 |
DT |
denotes |
the |
T24653 |
257-266 |
NN |
denotes |
synthesis |
T24654 |
267-270 |
CC |
denotes |
and |
T24655 |
271-280 |
NN |
denotes |
transport |
T24656 |
281-283 |
IN |
denotes |
of |
T24657 |
284-285 |
DT |
denotes |
a |
T24658 |
292-298 |
NN |
denotes |
cohort |
T24659 |
286-291 |
JJ |
denotes |
large |
T24660 |
299-301 |
IN |
denotes |
of |
T24661 |
302-305 |
NN |
denotes |
SAC |
T24662 |
306-314 |
NN |
denotes |
proteins |
T24663 |
314-315 |
. |
denotes |
. |
T24664 |
315-528 |
sentence |
denotes |
These data expand insight into the development of these important interneurons, but more critically, provide to our knowledge the first unambiguous evidence that Rb regulates neurogenesis beyond terminal mitosis. |
T24665 |
316-321 |
DT |
denotes |
These |
T24666 |
322-326 |
NNS |
denotes |
data |
T24667 |
327-333 |
VBP |
denotes |
expand |
T24668 |
334-341 |
NN |
denotes |
insight |
T24669 |
342-346 |
IN |
denotes |
into |
T24670 |
347-350 |
DT |
denotes |
the |
T24671 |
351-362 |
NN |
denotes |
development |
T24672 |
363-365 |
IN |
denotes |
of |
T24673 |
366-371 |
DT |
denotes |
these |
T24674 |
382-394 |
NNS |
denotes |
interneurons |
T24675 |
372-381 |
JJ |
denotes |
important |
T24676 |
394-396 |
, |
denotes |
, |
T24677 |
396-399 |
CC |
denotes |
but |
T24678 |
400-404 |
RBR |
denotes |
more |
T24679 |
405-415 |
RB |
denotes |
critically |
T24680 |
417-424 |
VB |
denotes |
provide |
T24681 |
415-417 |
, |
denotes |
, |
T24682 |
425-427 |
IN |
denotes |
to |
T24683 |
428-431 |
PRP$ |
denotes |
our |
T24684 |
432-441 |
NN |
denotes |
knowledge |
T24685 |
442-445 |
DT |
denotes |
the |
T24686 |
464-472 |
NN |
denotes |
evidence |
T24687 |
446-451 |
JJ |
denotes |
first |
T24688 |
452-463 |
JJ |
denotes |
unambiguous |
T24689 |
473-477 |
IN |
denotes |
that |
T24690 |
481-490 |
VBZ |
denotes |
regulates |
T24691 |
478-480 |
NN |
denotes |
Rb |
T24692 |
491-503 |
NN |
denotes |
neurogenesis |
T24693 |
504-510 |
IN |
denotes |
beyond |
T24694 |
511-519 |
JJ |
denotes |
terminal |
T24695 |
520-527 |
NN |
denotes |
mitosis |
T24696 |
527-528 |
. |
denotes |
. |
T24697 |
528-748 |
sentence |
denotes |
Rb binds more than 100 factors [43], and in several non-neuronal cells, such as skeletal muscle, adipocytes, and bone, it binds and potentiates tissue-specific transcription factors that promote differentiation [31–33]. |
T24698 |
529-531 |
NN |
denotes |
Rb |
T24699 |
532-537 |
VBZ |
denotes |
binds |
T24700 |
538-542 |
JJR |
denotes |
more |
T24701 |
548-551 |
CD |
denotes |
100 |
T24702 |
543-547 |
IN |
denotes |
than |
T24703 |
552-559 |
NNS |
denotes |
factors |
T24704 |
560-561 |
-LRB- |
denotes |
[ |
T24705 |
561-563 |
CD |
denotes |
43 |
T24706 |
563-564 |
-RRB- |
denotes |
] |
T24707 |
564-566 |
, |
denotes |
, |
T24708 |
566-569 |
CC |
denotes |
and |
T24709 |
570-572 |
IN |
denotes |
in |
T24710 |
651-656 |
VBZ |
denotes |
binds |
T24711 |
573-580 |
JJ |
denotes |
several |
T24712 |
594-599 |
NNS |
denotes |
cells |
T24713 |
581-593 |
JJ |
denotes |
non-neuronal |
T24714 |
599-601 |
, |
denotes |
, |
T24715 |
601-605 |
JJ |
denotes |
such |
T24716 |
606-608 |
IN |
denotes |
as |
T24738 |
743-744 |
SYM |
denotes |
– |
T24739 |
744-746 |
CD |
denotes |
33 |
T24740 |
746-747 |
-RRB- |
denotes |
] |
T24741 |
747-748 |
. |
denotes |
. |
T24742 |
748-921 |
sentence |
denotes |
The idea that Rb promotes muscle differentiation by potentiating Myod1 activity was contested [61], and other mechanisms proposed [62,63], but not involving E2f repression. |
T24743 |
749-752 |
DT |
denotes |
The |
T24744 |
753-757 |
NN |
denotes |
idea |
T24745 |
833-842 |
VBN |
denotes |
contested |
T24746 |
758-762 |
IN |
denotes |
that |
T24747 |
766-774 |
VBZ |
denotes |
promotes |
T24748 |
763-765 |
NN |
denotes |
Rb |
T24749 |
775-781 |
NN |
denotes |
muscle |
T24750 |
782-797 |
NN |
denotes |
differentiation |
T24751 |
798-800 |
IN |
denotes |
by |
T24752 |
801-813 |
VBG |
denotes |
potentiating |
T24753 |
814-819 |
NN |
denotes |
Myod1 |
T24754 |
820-828 |
NN |
denotes |
activity |
T24755 |
829-832 |
VBD |
denotes |
was |
T24756 |
843-844 |
-LRB- |
denotes |
[ |
T24757 |
844-846 |
CD |
denotes |
61 |
T24758 |
846-847 |
-RRB- |
denotes |
] |
T24759 |
847-849 |
, |
denotes |
, |
T24760 |
849-852 |
CC |
denotes |
and |
T24761 |
853-858 |
JJ |
denotes |
other |
T24762 |
859-869 |
NNS |
denotes |
mechanisms |
T24763 |
870-878 |
VBN |
denotes |
proposed |
T24764 |
879-880 |
-LRB- |
denotes |
[ |
T24765 |
883-885 |
CD |
denotes |
63 |
T24766 |
880-882 |
CD |
denotes |
62 |
T24767 |
882-883 |
, |
denotes |
, |
T24768 |
885-886 |
-RRB- |
denotes |
] |
T24769 |
886-888 |
, |
denotes |
, |
T24770 |
888-891 |
CC |
denotes |
but |
T24771 |
896-905 |
VBG |
denotes |
involving |
T24772 |
892-895 |
RB |
denotes |
not |
T24773 |
906-909 |
NN |
denotes |
E2f |
T24774 |
910-920 |
NN |
denotes |
repression |
T24775 |
920-921 |
. |
denotes |
. |
T24776 |
921-1018 |
sentence |
denotes |
Strikingly, however, we discovered that Rb promotes SAC differentiation through E2f3 (Figure 8). |
T24777 |
922-932 |
RB |
denotes |
Strikingly |
T24778 |
946-956 |
VBD |
denotes |
discovered |
T24779 |
932-934 |
, |
denotes |
, |
T24780 |
934-941 |
RB |
denotes |
however |
T24781 |
941-943 |
, |
denotes |
, |
T24782 |
943-945 |
PRP |
denotes |
we |
T24783 |
957-961 |
IN |
denotes |
that |
T24784 |
965-973 |
VBZ |
denotes |
promotes |
T24785 |
962-964 |
NN |
denotes |
Rb |
T24786 |
974-977 |
NN |
denotes |
SAC |
T24787 |
978-993 |
NN |
denotes |
differentiation |
T24788 |
994-1001 |
IN |
denotes |
through |
T24789 |
1002-1006 |
NN |
denotes |
E2f3 |
T24790 |
1007-1008 |
-LRB- |
denotes |
( |
T24791 |
1008-1014 |
NN |
denotes |
Figure |
T24792 |
1015-1016 |
CD |
denotes |
8 |
T24793 |
1016-1017 |
-RRB- |
denotes |
) |
T24794 |
1017-1018 |
. |
denotes |
. |
T24795 |
1018-1019 |
sentence |
denotes |
|
T24796 |
1029-1035 |
sentence |
denotes |
Rb Reg |
T24797 |
1029-1031 |
NN |
denotes |
Rb |
T24798 |
1032-1034 |
NNS |
denotes |
Re |
T24799 |
1034-1035 |
IN |
denotes |
g |
T24826 |
1771-1774 |
PRP$ |
denotes |
its |
T24827 |
1775-1779 |
NN |
denotes |
role |
T24828 |
1780-1782 |
IN |
denotes |
in |
T24829 |
1783-1794 |
VBG |
denotes |
controlling |
T24830 |
1795-1803 |
NN |
denotes |
division |
T24831 |
1804-1806 |
CC |
denotes |
or |
T24832 |
1807-1812 |
NN |
denotes |
death |
T24833 |
1812-1814 |
: |
denotes |
: |
T24834 |
1814-1818 |
NN |
denotes |
E2f3 |
T24835 |
1819-1827 |
NN |
denotes |
deletion |
T24836 |
1836-1838 |
NN |
denotes |
Rb |
T24837 |
1839-1841 |
NN |
denotes |
KO |
T24838 |
1846-1853 |
NNS |
denotes |
defects |
T24839 |
1842-1845 |
NN |
denotes |
SAC |
T24840 |
1854-1857 |
CC |
denotes |
but |
T24841 |
1858-1861 |
VBD |
denotes |
did |
T24842 |
1866-1874 |
VB |
denotes |
suppress |
T24843 |
1862-1865 |
RB |
denotes |
not |
T24844 |
1875-1883 |
JJ |
denotes |
aberrant |
T24845 |
1884-1897 |
NN |
denotes |
proliferation |
T24846 |
1898-1900 |
CC |
denotes |
or |
T24847 |
1901-1906 |
NN |
denotes |
death |
T24848 |
1906-1908 |
, |
denotes |
, |
T24849 |
1908-1915 |
IN |
denotes |
whereas |
T24850 |
1930-1938 |
VBD |
denotes |
reversed |
T24851 |
1916-1920 |
NN |
denotes |
E2f1 |
T24852 |
1921-1929 |
NN |
denotes |
deletion |
T24853 |
1939-1947 |
JJ |
denotes |
abnormal |
T24854 |
1948-1961 |
NN |
denotes |
proliferation |
T24855 |
1962-1965 |
CC |
denotes |
and |
T24856 |
1966-1971 |
NN |
denotes |
death |
T24857 |
1972-1975 |
CC |
denotes |
but |
T24858 |
1976-1979 |
VBD |
denotes |
did |
T24859 |
1984-1990 |
VB |
denotes |
rescue |
T24860 |
1980-1983 |
RB |
denotes |
not |
T24861 |
1991-1994 |
NN |
denotes |
SAC |
T24862 |
1995-2010 |
NN |
denotes |
differentiation |
T24863 |
2010-2011 |
. |
denotes |
. |
T24864 |
2011-2099 |
sentence |
denotes |
Double labelling confirmed that E2f1 but not E2f3 deletion reversed Rb KO SAC division. |
T24865 |
2012-2018 |
JJ |
denotes |
Double |
T24866 |
2019-2028 |
NN |
denotes |
labelling |
T24867 |
2029-2038 |
VBD |
denotes |
confirmed |
T24868 |
2039-2043 |
IN |
denotes |
that |
T24869 |
2071-2079 |
VBD |
denotes |
reversed |
T24870 |
2044-2048 |
NN |
denotes |
E2f1 |
T24871 |
2062-2070 |
NN |
denotes |
deletion |
T24872 |
2049-2052 |
CC |
denotes |
but |
T24873 |
2053-2056 |
RB |
denotes |
not |
T24874 |
2057-2061 |
NN |
denotes |
E2f3 |
T24875 |
2080-2082 |
NN |
denotes |
Rb |
T24876 |
2083-2085 |
NN |
denotes |
KO |
T24877 |
2086-2089 |
NN |
denotes |
SAC |
T24878 |
2090-2098 |
NN |
denotes |
division |
T24879 |
2098-2099 |
. |
denotes |
. |
T24880 |
2099-2225 |
sentence |
denotes |
Moreover, deleting E2f1, but not E2f3, reversed deregulated expression of cell cycle and apoptotic genes in the Rb KO retina. |
T24881 |
2100-2108 |
RB |
denotes |
Moreover |
T24882 |
2139-2147 |
VBD |
denotes |
reversed |
T24883 |
2108-2110 |
, |
denotes |
, |
T24884 |
2110-2118 |
VBG |
denotes |
deleting |
T24885 |
2119-2123 |
NN |
denotes |
E2f1 |
T24886 |
2123-2125 |
, |
denotes |
, |
T24887 |
2125-2128 |
CC |
denotes |
but |
T24888 |
2129-2132 |
RB |
denotes |
not |
T24889 |
2133-2137 |
NN |
denotes |
E2f3 |
T24890 |
2137-2139 |
, |
denotes |
, |
T24891 |
2148-2159 |
VBN |
denotes |
deregulated |
T24892 |
2160-2170 |
NN |
denotes |
expression |
T24893 |
2171-2173 |
IN |
denotes |
of |
T24894 |
2174-2178 |
NN |
denotes |
cell |
T24895 |
2179-2184 |
NN |
denotes |
cycle |
T24896 |
2185-2188 |
CC |
denotes |
and |
T24897 |
2189-2198 |
JJ |
denotes |
apoptotic |
T24898 |
2199-2204 |
NNS |
denotes |
genes |
T24899 |
2205-2207 |
IN |
denotes |
in |
T24900 |
2208-2211 |
DT |
denotes |
the |
T24901 |
2218-2224 |
NN |
denotes |
retina |
T24902 |
2212-2214 |
NN |
denotes |
Rb |
T24903 |
2215-2217 |
NN |
denotes |
KO |
T24904 |
2224-2225 |
. |
denotes |
. |
T24905 |
2225-2366 |
sentence |
denotes |
E2f3 is expressed in a subset of CNS neurons (this work) and drives specific cell-cycle–independent defects in Rb KO forebrain neurons [53]. |
T24906 |
2226-2230 |
NN |
denotes |
E2f3 |
T24907 |
2234-2243 |
VBN |
denotes |
expressed |
T24908 |
2231-2233 |
VBZ |
denotes |
is |
T24909 |
2244-2246 |
IN |
denotes |
in |
T24910 |
2247-2248 |
DT |
denotes |
a |
T24911 |
2249-2255 |
NN |
denotes |
subset |
T24912 |
2256-2258 |
IN |
denotes |
of |
T24913 |
2259-2262 |
NN |
denotes |
CNS |
T24914 |
2263-2270 |
NNS |
denotes |
neurons |
T24915 |
2271-2272 |
-LRB- |
denotes |
( |
T24916 |
2277-2281 |
NN |
denotes |
work |
T24917 |
2272-2276 |
DT |
denotes |
this |
T24918 |
2281-2282 |
-RRB- |
denotes |
) |
T24919 |
2283-2286 |
CC |
denotes |
and |
T24920 |
2287-2293 |
VBZ |
denotes |
drives |
T24921 |
2294-2302 |
JJ |
denotes |
specific |
T24922 |
2326-2333 |
NNS |
denotes |
defects |
T24923 |
2303-2307 |
NN |
denotes |
cell |
T24924 |
2308-2313 |
NN |
denotes |
cycle |
T24925 |
2307-2308 |
HYPH |
denotes |
- |
T24926 |
2314-2325 |
JJ |
denotes |
independent |
T24927 |
2313-2314 |
HYPH |
denotes |
– |
T24928 |
2334-2336 |
IN |
denotes |
in |
T24929 |
2337-2339 |
NN |
denotes |
Rb |
T24930 |
2340-2342 |
NN |
denotes |
KO |
T24931 |
2353-2360 |
NNS |
denotes |
neurons |
T24932 |
2343-2352 |
NN |
denotes |
forebrain |
T24933 |
2361-2362 |
-LRB- |
denotes |
[ |
T24934 |
2362-2364 |
CD |
denotes |
53 |
T24935 |
2364-2365 |
-RRB- |
denotes |
] |
T24936 |
2365-2366 |
. |
denotes |
. |
T24937 |
2366-2496 |
sentence |
denotes |
Thus, E2f3 inhibition is the first, and may be the only, mechanism by which Rb participates directly in neuronal differentiation. |
T24938 |
2367-2371 |
RB |
denotes |
Thus |
T24939 |
2389-2391 |
VBZ |
denotes |
is |
T24940 |
2371-2373 |
, |
denotes |
, |
T24941 |
2373-2377 |
NN |
denotes |
E2f3 |
T24942 |
2378-2388 |
NN |
denotes |
inhibition |
T24943 |
2392-2395 |
DT |
denotes |
the |
T24944 |
2396-2401 |
JJ |
denotes |
first |
T24945 |
2401-2403 |
, |
denotes |
, |
T24946 |
2403-2406 |
CC |
denotes |
and |
T24947 |
2407-2410 |
MD |
denotes |
may |
T24948 |
2411-2413 |
VB |
denotes |
be |
T24949 |
2414-2417 |
DT |
denotes |
the |
T24950 |
2418-2422 |
JJ |
denotes |
only |
T24951 |
2422-2424 |
, |
denotes |
, |
T24952 |
2424-2433 |
NN |
denotes |
mechanism |
T24953 |
2434-2436 |
IN |
denotes |
by |
T24954 |
2446-2458 |
VBZ |
denotes |
participates |
T24955 |
2437-2442 |
WDT |
denotes |
which |
T24956 |
2443-2445 |
NN |
denotes |
Rb |
T24957 |
2459-2467 |
RB |
denotes |
directly |
T24958 |
2468-2470 |
IN |
denotes |
in |
T24959 |
2471-2479 |
JJ |
denotes |
neuronal |
T24960 |
2480-2495 |
NN |
denotes |
differentiation |
T24961 |
2495-2496 |
. |
denotes |
. |
T24962 |
2496-2623 |
sentence |
denotes |
To further dissect the mechanism of action of Rb in SACs we determined the E2f3 isoform it targets to promote differentiation. |
T24963 |
2497-2499 |
TO |
denotes |
To |
T24964 |
2508-2515 |
VB |
denotes |
dissect |
T24965 |
2500-2507 |
RB |
denotes |
further |
T24966 |
2557-2567 |
VBD |
denotes |
determined |
T24967 |
2516-2519 |
DT |
denotes |
the |
T24968 |
2520-2529 |
NN |
denotes |
mechanism |
T24969 |
2530-2532 |
IN |
denotes |
of |
T24970 |
2533-2539 |
NN |
denotes |
action |
T24971 |
2540-2542 |
IN |
denotes |
of |
T24972 |
2543-2545 |
NN |
denotes |
Rb |
T24973 |
2546-2548 |
IN |
denotes |
in |
T24974 |
2549-2553 |
NNS |
denotes |
SACs |
T24975 |
2554-2556 |
PRP |
denotes |
we |
T24976 |
2568-2571 |
DT |
denotes |
the |
T24977 |
2577-2584 |
NN |
denotes |
isoform |
T24978 |
2572-2576 |
NN |
denotes |
E2f3 |
T24979 |
2585-2587 |
PRP |
denotes |
it |
T24980 |
2588-2595 |
VBZ |
denotes |
targets |
T24981 |
2596-2598 |
TO |
denotes |
to |
T24982 |
2599-2606 |
VB |
denotes |
promote |
T24983 |
2607-2622 |
NN |
denotes |
differentiation |
T24984 |
2622-2623 |
. |
denotes |
. |
T24985 |
2623-2740 |
sentence |
denotes |
E2f3b was the primary candidate, since Rb and E2f3b collaborate to repress targets in quiescent cells in vitro [19]. |
T24986 |
2624-2629 |
NN |
denotes |
E2f3b |
T24987 |
2630-2633 |
VBD |
denotes |
was |
T24988 |
2634-2637 |
DT |
denotes |
the |
T24989 |
2646-2655 |
NN |
denotes |
candidate |
T24990 |
2638-2645 |
JJ |
denotes |
primary |
T24991 |
2655-2657 |
, |
denotes |
, |
T24992 |
2657-2662 |
IN |
denotes |
since |
T24993 |
2676-2687 |
VBP |
denotes |
collaborate |
T24994 |
2663-2665 |
NN |
denotes |
Rb |
T24995 |
2666-2669 |
CC |
denotes |
and |
T24996 |
2670-2675 |
NN |
denotes |
E2f3b |
T24997 |
2688-2690 |
TO |
denotes |
to |
T24998 |
2691-2698 |
VB |
denotes |
repress |
T24999 |
2699-2706 |
NNS |
denotes |
targets |
T25000 |
2707-2709 |
IN |
denotes |
in |
T25001 |
2710-2719 |
JJ |
denotes |
quiescent |
T25002 |
2720-2725 |
NNS |
denotes |
cells |
T25003 |
2726-2728 |
FW |
denotes |
in |
T25004 |
2729-2734 |
FW |
denotes |
vitro |
T25005 |
2735-2736 |
-LRB- |
denotes |
[ |
T25006 |
2736-2738 |
CD |
denotes |
19 |
T25007 |
2738-2739 |
-RRB- |
denotes |
] |
T25008 |
2739-2740 |
. |
denotes |
. |
T25009 |
2740-2943 |
sentence |
denotes |
However, in the first work to our knowledge to examine the function of any E2f protein isoform in vivo, we made the surprising observation that Rb regulates SAC differentiation through E2f3a (Figure 8). |
T25010 |
2741-2748 |
RB |
denotes |
However |
T25011 |
2848-2852 |
VBD |
denotes |
made |
T25012 |
2748-2750 |
, |
denotes |
, |
T25013 |
2750-2752 |
IN |
denotes |
in |
T25014 |
2753-2756 |
DT |
denotes |
the |
T25015 |
2763-2767 |
NN |
denotes |
work |
T25016 |
2757-2762 |
JJ |
denotes |
first |
T25017 |
2768-2770 |
IN |
denotes |
to |
T25018 |
2788-2795 |
VB |
denotes |
examine |
T25019 |
2771-2774 |
PRP$ |
denotes |
our |
T25020 |
2775-2784 |
NN |
denotes |
knowledge |
T25021 |
2785-2787 |
TO |
denotes |
to |
T25022 |
2796-2799 |
DT |
denotes |
the |
T25023 |
2800-2808 |
NN |
denotes |
function |
T25024 |
2809-2811 |
IN |
denotes |
of |
T25025 |
2812-2815 |
DT |
denotes |
any |
T25026 |
2828-2835 |
NN |
denotes |
isoform |
T25027 |
2816-2819 |
NN |
denotes |
E2f |
T25028 |
2820-2827 |
NN |
denotes |
protein |
T25029 |
2836-2838 |
FW |
denotes |
in |
T25030 |
2839-2843 |
FW |
denotes |
vivo |
T25031 |
2843-2845 |
, |
denotes |
, |
T25032 |
2845-2847 |
PRP |
denotes |
we |
T25033 |
2853-2856 |
DT |
denotes |
the |
T25034 |
2868-2879 |
NN |
denotes |
observation |
T25035 |
2857-2867 |
JJ |
denotes |
surprising |
T25036 |
2880-2884 |
IN |
denotes |
that |
T25037 |
2888-2897 |
VBZ |
denotes |
regulates |
T25038 |
2885-2887 |
NN |
denotes |
Rb |
T25039 |
2898-2901 |
NN |
denotes |
SAC |
T25040 |
2902-2917 |
NN |
denotes |
differentiation |
T25041 |
2918-2925 |
IN |
denotes |
through |
T25042 |
2926-2931 |
NN |
denotes |
E2f3a |
T25043 |
2932-2933 |
-LRB- |
denotes |
( |
T25044 |
2933-2939 |
NN |
denotes |
Figure |
T25045 |
2940-2941 |
CD |
denotes |
8 |
T25046 |
2941-2942 |
-RRB- |
denotes |
) |
T25047 |
2942-2943 |
. |
denotes |
. |
T25048 |
2943-3109 |
sentence |
denotes |
Formally, we cannot exclude the possibility that deleting E2f3b might also rescue SAC differentiation, but definitive proof will require analysis of E2f3b null mice. |
T25049 |
2944-2952 |
RB |
denotes |
Formally |
T25050 |
2964-2971 |
VB |
denotes |
exclude |
T25051 |
2952-2954 |
, |
denotes |
, |
T25052 |
2954-2956 |
PRP |
denotes |
we |
T25053 |
2957-2960 |
MD |
denotes |
can |
T25054 |
2960-2963 |
RB |
denotes |
not |
T25055 |
2972-2975 |
DT |
denotes |
the |
T25056 |
2976-2987 |
NN |
denotes |
possibility |
T25057 |
2988-2992 |
IN |
denotes |
that |
T25058 |
3019-3025 |
VB |
denotes |
rescue |
T25059 |
2993-3001 |
VBG |
denotes |
deleting |
T25060 |
3002-3007 |
NN |
denotes |
E2f3b |
T25061 |
3008-3013 |
MD |
denotes |
might |
T25062 |
3014-3018 |
RB |
denotes |
also |
T25063 |
3026-3029 |
NN |
denotes |
SAC |
T25064 |
3030-3045 |
NN |
denotes |
differentiation |
T25065 |
3045-3047 |
, |
denotes |
, |
T25066 |
3047-3050 |
CC |
denotes |
but |
T25067 |
3051-3061 |
JJ |
denotes |
definitive |
T25068 |
3062-3067 |
NN |
denotes |
proof |
T25069 |
3073-3080 |
VB |
denotes |
require |
T25070 |
3068-3072 |
MD |
denotes |
will |
T25071 |
3081-3089 |
NN |
denotes |
analysis |
T25072 |
3090-3092 |
IN |
denotes |
of |
T25073 |
3093-3098 |
NN |
denotes |
E2f3b |
T25074 |
3099-3103 |
JJ |
denotes |
null |
T25075 |
3104-3108 |
NNS |
denotes |
mice |
T25076 |
3108-3109 |
. |
denotes |
. |
T25077 |
3109-3224 |
sentence |
denotes |
Nevertheless, our data prove that Rb definitely regulates SAC differentiation through the activating E2f3 isoform. |
T25078 |
3110-3122 |
RB |
denotes |
Nevertheless |
T25079 |
3133-3138 |
VBP |
denotes |
prove |
T25080 |
3122-3124 |
, |
denotes |
, |
T25081 |
3124-3127 |
PRP$ |
denotes |
our |
T25082 |
3128-3132 |
NNS |
denotes |
data |
T25083 |
3139-3143 |
IN |
denotes |
that |
T25084 |
3158-3167 |
VBZ |
denotes |
regulates |
T25085 |
3144-3146 |
NN |
denotes |
Rb |
T25086 |
3147-3157 |
RB |
denotes |
definitely |
T25087 |
3168-3171 |
NN |
denotes |
SAC |
T25088 |
3172-3187 |
NN |
denotes |
differentiation |
T25089 |
3188-3195 |
IN |
denotes |
through |
T25090 |
3196-3199 |
DT |
denotes |
the |
T25091 |
3216-3223 |
NN |
denotes |
isoform |
T25092 |
3200-3210 |
VBG |
denotes |
activating |
T25093 |
3211-3215 |
NN |
denotes |
E2f3 |
T25094 |
3223-3224 |
. |
denotes |
. |
T38541 |
1029-1031 |
NN |
denotes |
Rb |
T38542 |
1032-1041 |
VBZ |
denotes |
Regulates |
T38543 |
1042-1050 |
JJ |
denotes |
Distinct |
T38544 |
1051-1060 |
NNS |
denotes |
Processes |
T38545 |
1061-1068 |
IN |
denotes |
through |
T38546 |
1069-1073 |
NN |
denotes |
E2f1 |
T38547 |
1074-1077 |
CC |
denotes |
and |
T38548 |
1078-1083 |
NN |
denotes |
E2f3a |
T38549 |
1083-1133 |
sentence |
denotes |
Red text and arrows indicate Rb-dependent events. |
T38550 |
1084-1087 |
JJ |
denotes |
Red |
T38551 |
1088-1092 |
NN |
denotes |
text |
T38552 |
1104-1112 |
VBP |
denotes |
indicate |
T38553 |
1093-1096 |
CC |
denotes |
and |
T38554 |
1097-1103 |
NNS |
denotes |
arrows |
T38555 |
1113-1115 |
NN |
denotes |
Rb |
T38556 |
1116-1125 |
JJ |
denotes |
dependent |
T38557 |
1115-1116 |
HYPH |
denotes |
- |
T38558 |
1126-1132 |
NNS |
denotes |
events |
T38559 |
1132-1133 |
. |
denotes |
. |
T38560 |
1133-1228 |
sentence |
denotes |
Black text and arrows indicate events for which there is no direct evidence of Rb involvement. |
T38561 |
1134-1139 |
JJ |
denotes |
Black |
T38562 |
1140-1144 |
NN |
denotes |
text |
T38563 |
1156-1164 |
VBP |
denotes |
indicate |
T38564 |
1145-1148 |
CC |
denotes |
and |
T38565 |
1149-1155 |
NNS |
denotes |
arrows |
T38566 |
1165-1171 |
NNS |
denotes |
events |
T38567 |
1172-1175 |
IN |
denotes |
for |
T38568 |
1188-1190 |
VBZ |
denotes |
is |
T38569 |
1176-1181 |
WDT |
denotes |
which |
T38570 |
1182-1187 |
EX |
denotes |
there |
T38571 |
1191-1193 |
DT |
denotes |
no |
T38572 |
1201-1209 |
NN |
denotes |
evidence |
T38573 |
1194-1200 |
JJ |
denotes |
direct |
T38574 |
1210-1212 |
IN |
denotes |
of |
T38575 |
1213-1215 |
NN |
denotes |
Rb |
T38576 |
1216-1227 |
NN |
denotes |
involvement |
T38577 |
1227-1228 |
. |
denotes |
. |
T38578 |
1228-1420 |
sentence |
denotes |
Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. |
T38579 |
1229-1231 |
NN |
denotes |
Rb |
T38580 |
1241-1247 |
VB |
denotes |
appear |
T38581 |
1232-1236 |
VBZ |
denotes |
does |
T38582 |
1237-1240 |
RB |
denotes |
not |
T38583 |
1248-1250 |
TO |
denotes |
to |
T38584 |
1251-1257 |
VB |
denotes |
temper |
T38585 |
1258-1261 |
NN |
denotes |
RPC |
T38586 |
1262-1271 |
NN |
denotes |
expansion |
T38587 |
1272-1275 |
CC |
denotes |
and |
T38588 |
1276-1278 |
VBZ |
denotes |
is |
T38589 |
1283-1291 |
VBN |
denotes |
required |
T38590 |
1279-1282 |
RB |
denotes |
not |
T38591 |
1292-1295 |
IN |
denotes |
for |
T38592 |
1296-1311 |
NN |
denotes |
differentiation |
T38593 |
1312-1314 |
IN |
denotes |
of |
T38594 |
1315-1319 |
NNS |
denotes |
RPCs |
T38595 |
1320-1324 |
IN |
denotes |
into |
T38596 |
1325-1329 |
NNS |
denotes |
RTCs |
T38597 |
1329-1331 |
, |
denotes |
, |
T38598 |
1331-1334 |
CC |
denotes |
but |
T38599 |
1335-1337 |
VBZ |
denotes |
is |
T38600 |
1338-1347 |
JJ |
denotes |
essential |
T38601 |
1348-1350 |
TO |
denotes |
to |
T38602 |
1351-1357 |
VB |
denotes |
couple |
T38603 |
1358-1361 |
NN |
denotes |
RTC |
T38604 |
1362-1367 |
NN |
denotes |
birth |
T38605 |
1368-1370 |
IN |
denotes |
to |
T38606 |
1371-1379 |
JJ |
denotes |
terminal |
T38607 |
1380-1387 |
NN |
denotes |
mitosis |
T38608 |
1387-1389 |
, |
denotes |
, |
T38609 |
1389-1393 |
RB |
denotes |
thus |
T38610 |
1394-1401 |
VBG |
denotes |
locking |
T38611 |
1402-1406 |
PRP |
denotes |
them |
T38612 |
1407-1410 |
RB |
denotes |
out |
T38613 |
1411-1413 |
IN |
denotes |
of |
T38614 |
1414-1419 |
NN |
denotes |
cycle |
T38615 |
1419-1420 |
. |
denotes |
. |
T38616 |
1420-1466 |
sentence |
denotes |
Rb performs this function by inhibiting E2f1. |
T38617 |
1421-1423 |
NN |
denotes |
Rb |
T38618 |
1424-1432 |
VBZ |
denotes |
performs |
T38619 |
1433-1437 |
DT |
denotes |
this |
T38620 |
1438-1446 |
NN |
denotes |
function |
T38621 |
1447-1449 |
IN |
denotes |
by |
T38622 |
1450-1460 |
VBG |
denotes |
inhibiting |
T38623 |
1461-1465 |
NN |
denotes |
E2f1 |
T38624 |
1465-1466 |
. |
denotes |
. |
T38625 |
1466-1555 |
sentence |
denotes |
Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. |
T38626 |
1467-1469 |
NN |
denotes |
Rb |
T38627 |
1478-1486 |
VBN |
denotes |
required |
T38628 |
1470-1472 |
VBZ |
denotes |
is |
T38629 |
1473-1477 |
RB |
denotes |
also |
T38630 |
1487-1490 |
IN |
denotes |
for |
T38631 |
1491-1494 |
NN |
denotes |
SAC |
T38632 |
1495-1510 |
NN |
denotes |
differentiation |
T38633 |
1510-1512 |
, |
denotes |
, |
T38634 |
1512-1515 |
CC |
denotes |
and |
T38635 |
1516-1518 |
IN |
denotes |
in |
T38636 |
1530-1534 |
VBZ |
denotes |
acts |
T38637 |
1519-1523 |
DT |
denotes |
this |
T38638 |
1524-1528 |
NN |
denotes |
case |
T38639 |
1528-1530 |
, |
denotes |
, |
T38640 |
1535-1537 |
IN |
denotes |
by |
T38641 |
1538-1548 |
VBG |
denotes |
inhibiting |
T38642 |
1549-1554 |
NN |
denotes |
E2f3a |
T38643 |
1554-1555 |
. |
denotes |
. |
T38644 |
1555-1653 |
sentence |
denotes |
There is no direct evidence that Rb is required for terminal differentiation of other cell types. |
T38645 |
1556-1561 |
EX |
denotes |
There |
T38646 |
1562-1564 |
VBZ |
denotes |
is |
T38647 |
1565-1567 |
DT |
denotes |
no |
T38648 |
1575-1583 |
NN |
denotes |
evidence |
T38649 |
1568-1574 |
JJ |
denotes |
direct |
T38650 |
1584-1588 |
IN |
denotes |
that |
T38651 |
1595-1603 |
VBN |
denotes |
required |
T38652 |
1589-1591 |
NN |
denotes |
Rb |
T38653 |
1592-1594 |
VBZ |
denotes |
is |
T38654 |
1604-1607 |
IN |
denotes |
for |
T38655 |
1608-1616 |
JJ |
denotes |
terminal |
T38656 |
1617-1632 |
NN |
denotes |
differentiation |
T38657 |
1633-1635 |
IN |
denotes |
of |
T38658 |
1636-1641 |
JJ |
denotes |
other |
T38659 |
1647-1652 |
NNS |
denotes |
types |
T38660 |
1642-1646 |
NN |
denotes |
cell |
T38661 |
1652-1653 |
. |
denotes |
. |
T38662 |
1653-1701 |
sentence |
denotes |
Colour codes and abbreviations as in Figure 1A. |
T38663 |
1654-1660 |
NN |
denotes |
Colour |
T38664 |
1661-1666 |
NNS |
denotes |
codes |
T38665 |
1667-1670 |
CC |
denotes |
and |
T38666 |
1671-1684 |
NNS |
denotes |
abbreviations |
T38667 |
1685-1687 |
IN |
denotes |
as |
T38668 |
1688-1690 |
IN |
denotes |
in |
T38669 |
1691-1697 |
NN |
denotes |
Figure |
T38670 |
1698-1700 |
NN |
denotes |
1A |
T38671 |
1700-1701 |
. |
denotes |
. |
T24729 |
680-688 |
JJ |
denotes |
specific |
T24730 |
679-680 |
HYPH |
denotes |
- |
T24731 |
703-710 |
NNS |
denotes |
factors |
T24732 |
689-702 |
NN |
denotes |
transcription |
T24733 |
711-715 |
WDT |
denotes |
that |
T24734 |
716-723 |
VBP |
denotes |
promote |
T24735 |
724-739 |
NN |
denotes |
differentiation |
T24736 |
740-741 |
-LRB- |
denotes |
[ |
T24737 |
741-743 |
CD |
denotes |
31 |
T24814 |
1741-1742 |
EX |
denotes |
r |
T24815 |
1742-1743 |
DT |
denotes |
o |
T24816 |
1743-1744 |
VBN |
denotes |
u |
T24817 |
1744-1745 |
sentence |
denotes |
g |
T24818 |
1744-1745 |
NN |
denotes |
g |
T24821 |
1745-1746 |
IN |
denotes |
h |
T24822 |
1747-1751 |
NN |
denotes |
E2f3 |
T24823 |
1828-1835 |
VBD |
denotes |
rescued |
T24824 |
1756-1767 |
JJ |
denotes |
independent |
T24825 |
1768-1770 |
IN |
denotes |
of |
T24717 |
609-617 |
JJ |
denotes |
skeletal |
T24718 |
618-624 |
NN |
denotes |
muscle |
T24719 |
624-626 |
, |
denotes |
, |
T24720 |
626-636 |
NNS |
denotes |
adipocytes |
T24721 |
636-638 |
, |
denotes |
, |
T24722 |
638-641 |
CC |
denotes |
and |
T24723 |
642-646 |
NN |
denotes |
bone |
T24724 |
646-648 |
, |
denotes |
, |
T24725 |
648-650 |
PRP |
denotes |
it |
T24726 |
657-660 |
CC |
denotes |
and |
T24727 |
661-672 |
VBZ |
denotes |
potentiates |
T24728 |
673-679 |
NN |
denotes |
tissue |
T24800 |
1035-1719 |
sentence |
denotes |
ulates Distinct Processes through E2f1 and E2f3a
Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulation of |
T24801 |
1035-1036 |
VBN |
denotes |
u |
T24802 |
1036-1037 |
JJ |
denotes |
l |
T24803 |
1037-1038 |
JJ |
denotes |
a |
T24804 |
1038-1713 |
NN |
denotes |
tes Distinct Processes through E2f1 and E2f3a
Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati |
T24805 |
1713-1715 |
VBG |
denotes |
on |
T24806 |
1716-1717 |
RB |
denotes |
o |
T24807 |
1717-1718 |
IN |
denotes |
f |
T24808 |
1719-1741 |
sentence |
denotes |
SAC differentiation th |
T24809 |
1719-1722 |
NN |
denotes |
SAC |
T24810 |
1723-1738 |
NN |
denotes |
differentiation |
T24811 |
1738-1739 |
, |
denotes |
|
T24812 |
1739-1741 |
DT |
denotes |
th |
T24813 |
1741-1744 |
sentence |
denotes |
rou |
T24819 |
1745-2011 |
sentence |
denotes |
h E2f3 was independent of its role in controlling division or death: E2f3 deletion rescued Rb KO SAC defects but did not suppress aberrant proliferation or death, whereas E2f1 deletion reversed abnormal proliferation and death but did not rescue SAC differentiation. |
T24820 |
1752-1755 |
VBD |
denotes |
was |
R7129 |
T24609 |
T24610 |
nsubj |
Rb,Controls |
R7130 |
T24611 |
T24612 |
compound |
SAC,Differentiation |
R7131 |
T24612 |
T24610 |
dobj |
Differentiation,Controls |
R7132 |
T24613 |
T24610 |
prep |
through,Controls |
R7133 |
T24614 |
T24613 |
pobj |
E2f3a,through |
R7134 |
T24616 |
T24617 |
amod |
Comprehensive,analysis |
R7135 |
T24617 |
T24619 |
nsubj |
analysis,revealed |
R7136 |
T24618 |
T24617 |
compound |
marker,analysis |
R7137 |
T24620 |
T24621 |
mark |
that,suppress |
R7138 |
T24621 |
T24619 |
ccomp |
suppress,revealed |
R7139 |
T24622 |
T24621 |
punct |
", ",suppress |
R7140 |
T24623 |
T24621 |
prep |
in,suppress |
R7141 |
T24624 |
T24625 |
amod |
striking,contrast |
R7142 |
T24625 |
T24623 |
pobj |
contrast,in |
R7143 |
T24626 |
T24625 |
prep |
to,contrast |
R7144 |
T24627 |
T24628 |
amod |
other,neurons |
R7145 |
T24628 |
T24626 |
pobj |
neurons,to |
R7146 |
T24629 |
T24628 |
amod |
retinal,neurons |
R7147 |
T24630 |
T24621 |
punct |
", ",suppress |
R7148 |
T24631 |
T24632 |
compound |
E2f1,deletion |
R7149 |
T24632 |
T24621 |
nsubj |
deletion,suppress |
R7150 |
T24633 |
T24621 |
aux |
did,suppress |
R7151 |
T24634 |
T24621 |
neg |
not,suppress |
R7152 |
T24635 |
T24621 |
dobj |
defects,suppress |
R7153 |
T24636 |
T24621 |
prep |
in,suppress |
R7154 |
T24637 |
T24638 |
nmod |
Rb,KO |
R7155 |
T24638 |
T24639 |
nmod |
KO,SACs |
R7156 |
T24639 |
T24636 |
pobj |
SACs,in |
R7157 |
T24640 |
T24639 |
amod |
cholinergic,SACs |
R7158 |
T24641 |
T24619 |
punct |
.,revealed |
R7159 |
T24643 |
T24644 |
advmod |
Instead,observed |
R7160 |
T24645 |
T24644 |
punct |
", ",observed |
R7161 |
T24646 |
T24644 |
nsubj |
we,observed |
R7162 |
T24647 |
T24648 |
npadvmod |
E2f1,independent |
R7163 |
T24648 |
T24650 |
amod |
independent,defects |
R7164 |
T24649 |
T24648 |
punct |
-,independent |
R7165 |
T24650 |
T24644 |
dobj |
defects,observed |
R7166 |
T24651 |
T24650 |
prep |
in,defects |
R7167 |
T24652 |
T24653 |
det |
the,synthesis |
R7168 |
T24653 |
T24651 |
pobj |
synthesis,in |
R7169 |
T24654 |
T24653 |
cc |
and,synthesis |
R7170 |
T24655 |
T24653 |
conj |
transport,synthesis |
R7171 |
T24656 |
T24653 |
prep |
of,synthesis |
R7172 |
T24657 |
T24658 |
det |
a,cohort |
R7173 |
T24658 |
T24656 |
pobj |
cohort,of |
R7174 |
T24659 |
T24658 |
amod |
large,cohort |
R7175 |
T24660 |
T24658 |
prep |
of,cohort |
R7176 |
T24661 |
T24662 |
compound |
SAC,proteins |
R7177 |
T24662 |
T24660 |
pobj |
proteins,of |
R7178 |
T24663 |
T24644 |
punct |
.,observed |
R7179 |
T24665 |
T24666 |
det |
These,data |
R7180 |
T24666 |
T24667 |
nsubj |
data,expand |
R7181 |
T24668 |
T24667 |
dobj |
insight,expand |
R7182 |
T24669 |
T24668 |
prep |
into,insight |
R7183 |
T24670 |
T24671 |
det |
the,development |
R7184 |
T24671 |
T24669 |
pobj |
development,into |
R7185 |
T24672 |
T24671 |
prep |
of,development |
R7186 |
T24673 |
T24674 |
det |
these,interneurons |
R7187 |
T24674 |
T24672 |
pobj |
interneurons,of |
R7188 |
T24675 |
T24674 |
amod |
important,interneurons |
R7189 |
T24676 |
T24667 |
punct |
", ",expand |
R7190 |
T24677 |
T24667 |
cc |
but,expand |
R7191 |
T24678 |
T24679 |
advmod |
more,critically |
R7192 |
T24679 |
T24680 |
advmod |
critically,provide |
R7193 |
T24680 |
T24667 |
conj |
provide,expand |
R7194 |
T24681 |
T24680 |
punct |
", ",provide |
R7195 |
T24682 |
T24680 |
prep |
to,provide |
R7196 |
T24683 |
T24684 |
poss |
our,knowledge |
R7197 |
T24684 |
T24682 |
pobj |
knowledge,to |
R7198 |
T24685 |
T24686 |
det |
the,evidence |
R7199 |
T24686 |
T24680 |
dobj |
evidence,provide |
R7200 |
T24687 |
T24686 |
amod |
first,evidence |
R7201 |
T24688 |
T24686 |
amod |
unambiguous,evidence |
R7202 |
T24689 |
T24690 |
mark |
that,regulates |
R7203 |
T24690 |
T24686 |
acl |
regulates,evidence |
R7204 |
T24691 |
T24690 |
nsubj |
Rb,regulates |
R7205 |
T24692 |
T24690 |
dobj |
neurogenesis,regulates |
R7206 |
T24693 |
T24690 |
prep |
beyond,regulates |
R7207 |
T24694 |
T24695 |
amod |
terminal,mitosis |
R7208 |
T24695 |
T24693 |
pobj |
mitosis,beyond |
R7209 |
T24696 |
T24667 |
punct |
.,expand |
R7210 |
T24698 |
T24699 |
nsubj |
Rb,binds |
R7211 |
T24700 |
T24701 |
amod |
more,100 |
R7212 |
T24701 |
T24703 |
nummod |
100,factors |
R7213 |
T24702 |
T24701 |
quantmod |
than,100 |
R7214 |
T24703 |
T24699 |
dobj |
factors,binds |
R7215 |
T24704 |
T24705 |
punct |
[,43 |
R7216 |
T24705 |
T24699 |
parataxis |
43,binds |
R7217 |
T24706 |
T24705 |
punct |
],43 |
R7218 |
T24707 |
T24699 |
punct |
", ",binds |
R7219 |
T24708 |
T24699 |
cc |
and,binds |
R7220 |
T24709 |
T24710 |
prep |
in,binds |
R7221 |
T24710 |
T24699 |
conj |
binds,binds |
R7222 |
T24711 |
T24712 |
amod |
several,cells |
R7223 |
T24712 |
T24709 |
pobj |
cells,in |
R7224 |
T24713 |
T24712 |
amod |
non-neuronal,cells |
R7225 |
T24714 |
T24712 |
punct |
", ",cells |
R7226 |
T24715 |
T24716 |
amod |
such,as |
R7227 |
T24716 |
T24712 |
prep |
as,cells |
R7228 |
T24717 |
T24718 |
amod |
skeletal,muscle |
R7229 |
T24718 |
T24716 |
pobj |
muscle,as |
R7230 |
T24719 |
T24718 |
punct |
", ",muscle |
R7231 |
T24720 |
T24718 |
conj |
adipocytes,muscle |
R7232 |
T24721 |
T24720 |
punct |
", ",adipocytes |
R7233 |
T24722 |
T24720 |
cc |
and,adipocytes |
R7234 |
T24723 |
T24720 |
conj |
bone,adipocytes |
R7235 |
T24724 |
T24710 |
punct |
", ",binds |
R7236 |
T24725 |
T24710 |
nsubj |
it,binds |
R7237 |
T24726 |
T24710 |
cc |
and,binds |
R7238 |
T24727 |
T24710 |
conj |
potentiates,binds |
R7239 |
T24728 |
T24729 |
npadvmod |
tissue,specific |
R7240 |
T24729 |
T24731 |
amod |
specific,factors |
R7241 |
T24730 |
T24729 |
punct |
-,specific |
R7242 |
T24731 |
T24727 |
dobj |
factors,potentiates |
R7243 |
T24732 |
T24731 |
compound |
transcription,factors |
R7244 |
T24733 |
T24734 |
dep |
that,promote |
R7245 |
T24734 |
T24731 |
relcl |
promote,factors |
R7246 |
T24735 |
T24734 |
dobj |
differentiation,promote |
R7247 |
T24736 |
T24737 |
punct |
[,31 |
R7248 |
T24737 |
T24727 |
parataxis |
31,potentiates |
R7249 |
T24738 |
T24739 |
punct |
–,33 |
R7250 |
T24739 |
T24737 |
prep |
33,31 |
R7251 |
T24740 |
T24737 |
punct |
],31 |
R7252 |
T24741 |
T24710 |
punct |
.,binds |
R7253 |
T24743 |
T24744 |
det |
The,idea |
R7254 |
T24744 |
T24745 |
nsubjpass |
idea,contested |
R7255 |
T24746 |
T24747 |
mark |
that,promotes |
R7256 |
T24747 |
T24744 |
acl |
promotes,idea |
R7257 |
T24748 |
T24747 |
nsubj |
Rb,promotes |
R7258 |
T24749 |
T24750 |
compound |
muscle,differentiation |
R7259 |
T24750 |
T24747 |
dobj |
differentiation,promotes |
R7260 |
T24751 |
T24747 |
prep |
by,promotes |
R7261 |
T24752 |
T24751 |
pcomp |
potentiating,by |
R7262 |
T24753 |
T24754 |
compound |
Myod1,activity |
R7263 |
T24754 |
T24752 |
dobj |
activity,potentiating |
R7264 |
T24755 |
T24745 |
auxpass |
was,contested |
R7265 |
T24756 |
T24757 |
punct |
[,61 |
R7266 |
T24757 |
T24745 |
parataxis |
61,contested |
R7267 |
T24758 |
T24757 |
punct |
],61 |
R7268 |
T24759 |
T24745 |
punct |
", ",contested |
R7269 |
T24760 |
T24745 |
cc |
and,contested |
R7270 |
T24761 |
T24762 |
amod |
other,mechanisms |
R7271 |
T24762 |
T24763 |
nsubj |
mechanisms,proposed |
R7307 |
T24822 |
T24821 |
pobj |
E2f3,h |
R7308 |
T24824 |
T24820 |
acomp |
independent,was |
R7309 |
T24825 |
T24824 |
prep |
of,independent |
R7310 |
T24826 |
T24827 |
poss |
its,role |
R7311 |
T24827 |
T24825 |
pobj |
role,of |
R7312 |
T24828 |
T24827 |
prep |
in,role |
R7313 |
T24829 |
T24828 |
pcomp |
controlling,in |
R7314 |
T24830 |
T24829 |
dobj |
division,controlling |
R7315 |
T24831 |
T24830 |
cc |
or,division |
R7316 |
T24832 |
T24830 |
conj |
death,division |
R7317 |
T24833 |
T24823 |
punct |
: ,rescued |
R7318 |
T24834 |
T24835 |
compound |
E2f3,deletion |
R7319 |
T24835 |
T24823 |
nsubj |
deletion,rescued |
R7320 |
T24836 |
T24837 |
compound |
Rb,KO |
R7321 |
T24837 |
T24838 |
compound |
KO,defects |
R7322 |
T24838 |
T24823 |
dobj |
defects,rescued |
R7323 |
T24839 |
T24838 |
compound |
SAC,defects |
R7324 |
T24840 |
T24823 |
cc |
but,rescued |
R7325 |
T24841 |
T24842 |
aux |
did,suppress |
R7326 |
T24842 |
T24823 |
conj |
suppress,rescued |
R7327 |
T24843 |
T24842 |
neg |
not,suppress |
R7328 |
T24844 |
T24845 |
amod |
aberrant,proliferation |
R7329 |
T24845 |
T24842 |
dobj |
proliferation,suppress |
R7330 |
T24846 |
T24845 |
cc |
or,proliferation |
R7331 |
T24847 |
T24845 |
conj |
death,proliferation |
R7332 |
T24848 |
T24842 |
punct |
", ",suppress |
R7333 |
T24849 |
T24850 |
mark |
whereas,reversed |
R7334 |
T24850 |
T24842 |
advcl |
reversed,suppress |
R7335 |
T24851 |
T24852 |
compound |
E2f1,deletion |
R7336 |
T24852 |
T24850 |
nsubj |
deletion,reversed |
R7337 |
T24853 |
T24854 |
amod |
abnormal,proliferation |
R7338 |
T24854 |
T24850 |
dobj |
proliferation,reversed |
R7339 |
T24855 |
T24854 |
cc |
and,proliferation |
R7340 |
T24856 |
T24854 |
conj |
death,proliferation |
R7341 |
T24857 |
T24850 |
cc |
but,reversed |
R7342 |
T24858 |
T24859 |
aux |
did,rescue |
R7343 |
T24859 |
T24850 |
conj |
rescue,reversed |
R7344 |
T24860 |
T24859 |
neg |
not,rescue |
R7345 |
T24861 |
T24862 |
compound |
SAC,differentiation |
R7346 |
T24862 |
T24859 |
dobj |
differentiation,rescue |
R7347 |
T24863 |
T24823 |
punct |
.,rescued |
R7348 |
T24865 |
T24866 |
amod |
Double,labelling |
R7349 |
T24866 |
T24867 |
nsubj |
labelling,confirmed |
R7350 |
T24868 |
T24869 |
mark |
that,reversed |
R7351 |
T24869 |
T24867 |
ccomp |
reversed,confirmed |
R7352 |
T24870 |
T24871 |
nmod |
E2f1,deletion |
R7353 |
T24871 |
T24869 |
nsubj |
deletion,reversed |
R7354 |
T24872 |
T24870 |
cc |
but,E2f1 |
R7355 |
T24873 |
T24872 |
neg |
not,but |
R7356 |
T24874 |
T24870 |
conj |
E2f3,E2f1 |
R7357 |
T24875 |
T24876 |
compound |
Rb,KO |
R7358 |
T24876 |
T24877 |
compound |
KO,SAC |
R7359 |
T24877 |
T24878 |
compound |
SAC,division |
R7360 |
T24878 |
T24869 |
dobj |
division,reversed |
R7361 |
T24879 |
T24867 |
punct |
.,confirmed |
R7362 |
T24881 |
T24882 |
advmod |
Moreover,reversed |
R7363 |
T24883 |
T24882 |
punct |
", ",reversed |
R7364 |
T24884 |
T24882 |
csubj |
deleting,reversed |
R7365 |
T24885 |
T24884 |
dobj |
E2f1,deleting |
R7366 |
T24886 |
T24885 |
punct |
", ",E2f1 |
R7367 |
T24887 |
T24885 |
cc |
but,E2f1 |
R7368 |
T24888 |
T24887 |
neg |
not,but |
R7369 |
T24889 |
T24885 |
conj |
E2f3,E2f1 |
R7370 |
T24890 |
T24882 |
punct |
", ",reversed |
R7371 |
T24891 |
T24892 |
amod |
deregulated,expression |
R7372 |
T24892 |
T24882 |
dobj |
expression,reversed |
R7373 |
T24893 |
T24892 |
prep |
of,expression |
R7374 |
T24894 |
T24895 |
compound |
cell,cycle |
R7375 |
T24895 |
T24893 |
pobj |
cycle,of |
R7376 |
T24896 |
T24895 |
cc |
and,cycle |
R7377 |
T24897 |
T24898 |
amod |
apoptotic,genes |
R7378 |
T24898 |
T24895 |
conj |
genes,cycle |
R7379 |
T24899 |
T24882 |
prep |
in,reversed |
R7380 |
T24900 |
T24901 |
det |
the,retina |
R7381 |
T24901 |
T24899 |
pobj |
retina,in |
R7382 |
T24902 |
T24903 |
compound |
Rb,KO |
R7383 |
T24903 |
T24901 |
compound |
KO,retina |
R7384 |
T24904 |
T24882 |
punct |
.,reversed |
R7385 |
T24906 |
T24907 |
nsubjpass |
E2f3,expressed |
R7386 |
T24908 |
T24907 |
auxpass |
is,expressed |
R7387 |
T24909 |
T24907 |
prep |
in,expressed |
R7388 |
T24910 |
T24911 |
det |
a,subset |
R7389 |
T24911 |
T24909 |
pobj |
subset,in |
R7400 |
T24922 |
T24920 |
dobj |
defects,drives |
R7402 |
T24924 |
T24926 |
npadvmod |
cycle,independent |
R7403 |
T24925 |
T24924 |
punct |
-,cycle |
R7404 |
T24926 |
T24922 |
amod |
independent,defects |
R7405 |
T24927 |
T24926 |
punct |
–,independent |
R7406 |
T24928 |
T24920 |
prep |
in,drives |
R7407 |
T24929 |
T24930 |
compound |
Rb,KO |
R7408 |
T24930 |
T24931 |
compound |
KO,neurons |
R7409 |
T24931 |
T24928 |
pobj |
neurons,in |
R7410 |
T24932 |
T24931 |
compound |
forebrain,neurons |
R7411 |
T24933 |
T24934 |
punct |
[,53 |
R7412 |
T24934 |
T24920 |
parataxis |
53,drives |
R7413 |
T24935 |
T24934 |
punct |
],53 |
R7414 |
T24936 |
T24907 |
punct |
.,expressed |
R7415 |
T24938 |
T24939 |
advmod |
Thus,is |
R7416 |
T24940 |
T24939 |
punct |
", ",is |
R7417 |
T24941 |
T24942 |
compound |
E2f3,inhibition |
R7418 |
T24942 |
T24939 |
nsubj |
inhibition,is |
R7419 |
T24943 |
T24944 |
det |
the,first |
R7420 |
T24944 |
T24939 |
attr |
first,is |
R7421 |
T24945 |
T24939 |
punct |
", ",is |
R7422 |
T24946 |
T24939 |
cc |
and,is |
R7423 |
T24947 |
T24948 |
aux |
may,be |
R7424 |
T24948 |
T24939 |
conj |
be,is |
R7425 |
T24949 |
T24950 |
det |
the,only |
R7426 |
T24950 |
T24948 |
attr |
only,be |
R7427 |
T24951 |
T24948 |
punct |
", ",be |
R7428 |
T24952 |
T24948 |
conj |
mechanism,be |
R7429 |
T24953 |
T24954 |
prep |
by,participates |
R7430 |
T24954 |
T24952 |
ccomp |
participates,mechanism |
R7431 |
T24955 |
T24953 |
pobj |
which,by |
R7432 |
T24956 |
T24954 |
nsubj |
Rb,participates |
R7433 |
T24957 |
T24954 |
advmod |
directly,participates |
R7434 |
T24958 |
T24954 |
prep |
in,participates |
R7435 |
T24959 |
T24960 |
amod |
neuronal,differentiation |
R7436 |
T24960 |
T24958 |
pobj |
differentiation,in |
R7437 |
T24961 |
T24939 |
punct |
.,is |
R7438 |
T24963 |
T24964 |
aux |
To,dissect |
R7439 |
T24964 |
T24966 |
advcl |
dissect,determined |
R7440 |
T24965 |
T24964 |
advmod |
further,dissect |
R7441 |
T24967 |
T24968 |
det |
the,mechanism |
R7442 |
T24968 |
T24964 |
dobj |
mechanism,dissect |
R7443 |
T24969 |
T24968 |
prep |
of,mechanism |
R7444 |
T24970 |
T24969 |
pobj |
action,of |
R7445 |
T24971 |
T24968 |
prep |
of,mechanism |
R7446 |
T24972 |
T24971 |
pobj |
Rb,of |
R7447 |
T24973 |
T24968 |
prep |
in,mechanism |
R7448 |
T24974 |
T24973 |
pobj |
SACs,in |
R7449 |
T24975 |
T24966 |
nsubj |
we,determined |
R7450 |
T24976 |
T24977 |
det |
the,isoform |
R7451 |
T24977 |
T24966 |
dobj |
isoform,determined |
R7452 |
T24978 |
T24977 |
compound |
E2f3,isoform |
R7453 |
T24979 |
T24980 |
nsubj |
it,targets |
R7454 |
T24980 |
T24977 |
advcl |
targets,isoform |
R7455 |
T24981 |
T24982 |
aux |
to,promote |
R7456 |
T24982 |
T24980 |
advcl |
promote,targets |
R7457 |
T24983 |
T24982 |
dobj |
differentiation,promote |
R7458 |
T24984 |
T24966 |
punct |
.,determined |
R7459 |
T24986 |
T24987 |
nsubj |
E2f3b,was |
R7460 |
T24988 |
T24989 |
det |
the,candidate |
R7461 |
T24989 |
T24987 |
attr |
candidate,was |
R7462 |
T24990 |
T24989 |
amod |
primary,candidate |
R7463 |
T24991 |
T24987 |
punct |
", ",was |
R7464 |
T24992 |
T24993 |
mark |
since,collaborate |
R7465 |
T24993 |
T24987 |
advcl |
collaborate,was |
R7466 |
T24994 |
T24993 |
nsubj |
Rb,collaborate |
R7467 |
T24995 |
T24994 |
cc |
and,Rb |
R7468 |
T24996 |
T24994 |
conj |
E2f3b,Rb |
R7469 |
T24997 |
T24998 |
aux |
to,repress |
R7470 |
T24998 |
T24993 |
advcl |
repress,collaborate |
R7471 |
T24999 |
T24998 |
dobj |
targets,repress |
R7472 |
T25000 |
T24998 |
prep |
in,repress |
R7473 |
T25001 |
T25002 |
amod |
quiescent,cells |
R7474 |
T25002 |
T25000 |
pobj |
cells,in |
R7475 |
T25003 |
T25004 |
advmod |
in,vitro |
R7476 |
T25004 |
T24998 |
advmod |
vitro,repress |
R7477 |
T25005 |
T25006 |
punct |
[,19 |
R7478 |
T25006 |
T24998 |
parataxis |
19,repress |
R7479 |
T25007 |
T25006 |
punct |
],19 |
R7480 |
T25008 |
T24987 |
punct |
.,was |
R7481 |
T25010 |
T25011 |
advmod |
However,made |
R7482 |
T25012 |
T25011 |
punct |
", ",made |
R7483 |
T25013 |
T25011 |
prep |
in,made |
R7484 |
T25014 |
T25015 |
det |
the,work |
R7485 |
T25015 |
T25013 |
pobj |
work,in |
R7486 |
T25016 |
T25015 |
amod |
first,work |
R7487 |
T25017 |
T25018 |
prep |
to,examine |
R7488 |
T25018 |
T25015 |
advcl |
examine,work |
R7489 |
T25019 |
T25020 |
poss |
our,knowledge |
R7490 |
T25020 |
T25017 |
pobj |
knowledge,to |
R7491 |
T25021 |
T25018 |
aux |
to,examine |
R7492 |
T25022 |
T25023 |
det |
the,function |
R7493 |
T25023 |
T25018 |
dobj |
function,examine |
R7494 |
T25024 |
T25023 |
prep |
of,function |
R7495 |
T25025 |
T25026 |
det |
any,isoform |
R7496 |
T25026 |
T25024 |
pobj |
isoform,of |
R7497 |
T25027 |
T25028 |
compound |
E2f,protein |
R7498 |
T25028 |
T25026 |
compound |
protein,isoform |
R7499 |
T25029 |
T25030 |
advmod |
in,vivo |
R7500 |
T25030 |
T25018 |
advmod |
vivo,examine |
R7501 |
T25031 |
T25011 |
punct |
", ",made |
R7502 |
T25032 |
T25011 |
nsubj |
we,made |
R7503 |
T25033 |
T25034 |
det |
the,observation |
R7504 |
T25034 |
T25011 |
dobj |
observation,made |
R7505 |
T25035 |
T25034 |
amod |
surprising,observation |
R7506 |
T25036 |
T25037 |
mark |
that,regulates |
R7507 |
T25037 |
T25034 |
acl |
regulates,observation |
R7508 |
T25038 |
T25037 |
nsubj |
Rb,regulates |
R7509 |
T25039 |
T25040 |
compound |
SAC,differentiation |
R7510 |
T25040 |
T25037 |
dobj |
differentiation,regulates |
R7511 |
T25041 |
T25037 |
prep |
through,regulates |
R7512 |
T25042 |
T25041 |
pobj |
E2f3a,through |
R7513 |
T25043 |
T25044 |
punct |
(,Figure |
R7514 |
T25044 |
T25037 |
parataxis |
Figure,regulates |
R7515 |
T25045 |
T25044 |
nummod |
8,Figure |
R7516 |
T25046 |
T25044 |
punct |
),Figure |
R7517 |
T25047 |
T25011 |
punct |
.,made |
R7518 |
T25049 |
T25050 |
advmod |
Formally,exclude |
R7519 |
T25051 |
T25050 |
punct |
", ",exclude |
R7520 |
T25052 |
T25050 |
nsubj |
we,exclude |
R7521 |
T25053 |
T25050 |
aux |
can,exclude |
R7522 |
T25054 |
T25050 |
neg |
not,exclude |
R7523 |
T25055 |
T25056 |
det |
the,possibility |
R7524 |
T25056 |
T25050 |
dobj |
possibility,exclude |
R7525 |
T25057 |
T25058 |
mark |
that,rescue |
R7526 |
T25058 |
T25056 |
acl |
rescue,possibility |
R7527 |
T25059 |
T25058 |
csubj |
deleting,rescue |
R7528 |
T25060 |
T25059 |
dobj |
E2f3b,deleting |
R7529 |
T25061 |
T25058 |
aux |
might,rescue |
R7530 |
T25062 |
T25058 |
advmod |
also,rescue |
R7531 |
T25063 |
T25064 |
compound |
SAC,differentiation |
R7532 |
T25064 |
T25058 |
dobj |
differentiation,rescue |
R7533 |
T25065 |
T25050 |
punct |
", ",exclude |
R7534 |
T25066 |
T25050 |
cc |
but,exclude |
R7535 |
T25067 |
T25068 |
amod |
definitive,proof |
R7536 |
T25068 |
T25069 |
nsubj |
proof,require |
R7537 |
T25069 |
T25050 |
conj |
require,exclude |
R7538 |
T25070 |
T25069 |
aux |
will,require |
R7539 |
T25071 |
T25069 |
dobj |
analysis,require |
R7540 |
T25072 |
T25071 |
prep |
of,analysis |
R7541 |
T25073 |
T25074 |
npadvmod |
E2f3b,null |
R7542 |
T25074 |
T25075 |
amod |
null,mice |
R7543 |
T25075 |
T25072 |
pobj |
mice,of |
R7544 |
T25076 |
T25069 |
punct |
.,require |
R7545 |
T25078 |
T25079 |
advmod |
Nevertheless,prove |
R7546 |
T25080 |
T25079 |
punct |
", ",prove |
R7547 |
T25081 |
T25082 |
poss |
our,data |
R7548 |
T25082 |
T25079 |
nsubj |
data,prove |
R7549 |
T25083 |
T25084 |
mark |
that,regulates |
R7550 |
T25084 |
T25079 |
ccomp |
regulates,prove |
R7551 |
T25085 |
T25084 |
nsubj |
Rb,regulates |
R7552 |
T25086 |
T25084 |
advmod |
definitely,regulates |
R7553 |
T25087 |
T25088 |
compound |
SAC,differentiation |
R7554 |
T25088 |
T25084 |
dobj |
differentiation,regulates |
R7555 |
T25089 |
T25084 |
prep |
through,regulates |
R7556 |
T25090 |
T25091 |
det |
the,isoform |
R7557 |
T25091 |
T25089 |
pobj |
isoform,through |
R7558 |
T25092 |
T25091 |
amod |
activating,isoform |
R7559 |
T25093 |
T25091 |
compound |
E2f3,isoform |
R7560 |
T25094 |
T25079 |
punct |
.,prove |
R11654 |
T38541 |
T38542 |
nsubj |
Rb,Regulates |
R11655 |
T38543 |
T38544 |
amod |
Distinct,Processes |
R11656 |
T38544 |
T38542 |
dobj |
Processes,Regulates |
R11657 |
T38545 |
T38542 |
prep |
through,Regulates |
R11658 |
T38546 |
T38545 |
pobj |
E2f1,through |
R11659 |
T38547 |
T38546 |
cc |
and,E2f1 |
R11660 |
T38548 |
T38546 |
conj |
E2f3a,E2f1 |
R11661 |
T38550 |
T38551 |
amod |
Red,text |
R11662 |
T38551 |
T38552 |
nsubj |
text,indicate |
R11663 |
T38553 |
T38551 |
cc |
and,text |
R11664 |
T38554 |
T38551 |
conj |
arrows,text |
R11665 |
T38555 |
T38556 |
npadvmod |
Rb,dependent |
R11666 |
T38556 |
T38558 |
amod |
dependent,events |
R11667 |
T38557 |
T38556 |
punct |
-,dependent |
R11668 |
T38558 |
T38552 |
dobj |
events,indicate |
R11669 |
T38559 |
T38552 |
punct |
.,indicate |
R11670 |
T38561 |
T38562 |
amod |
Black,text |
R11671 |
T38562 |
T38563 |
nsubj |
text,indicate |
R11672 |
T38564 |
T38562 |
cc |
and,text |
R11673 |
T38565 |
T38562 |
conj |
arrows,text |
R11674 |
T38566 |
T38563 |
dobj |
events,indicate |
R11675 |
T38567 |
T38568 |
prep |
for,is |
R11676 |
T38568 |
T38566 |
relcl |
is,events |
R11677 |
T38569 |
T38567 |
pobj |
which,for |
R11678 |
T38570 |
T38568 |
expl |
there,is |
R11679 |
T38571 |
T38572 |
det |
no,evidence |
R11680 |
T38572 |
T38568 |
attr |
evidence,is |
R11681 |
T38573 |
T38572 |
amod |
direct,evidence |
R11682 |
T38574 |
T38572 |
prep |
of,evidence |
R11683 |
T38575 |
T38576 |
compound |
Rb,involvement |
R11684 |
T38576 |
T38574 |
pobj |
involvement,of |
R11685 |
T38577 |
T38563 |
punct |
.,indicate |
R11686 |
T38579 |
T38580 |
nsubj |
Rb,appear |
R11687 |
T38581 |
T38580 |
aux |
does,appear |
R11688 |
T38582 |
T38580 |
neg |
not,appear |
R11689 |
T38583 |
T38584 |
aux |
to,temper |
R11690 |
T38584 |
T38580 |
xcomp |
temper,appear |
R11691 |
T38585 |
T38586 |
compound |
RPC,expansion |
R11692 |
T38586 |
T38584 |
dobj |
expansion,temper |
R11693 |
T38587 |
T38580 |
cc |
and,appear |
R11694 |
T38588 |
T38589 |
auxpass |
is,required |
R11695 |
T38589 |
T38580 |
conj |
required,appear |
R11696 |
T38590 |
T38589 |
neg |
not,required |
R11697 |
T38591 |
T38589 |
prep |
for,required |
R11698 |
T38592 |
T38591 |
pobj |
differentiation,for |
R11699 |
T38593 |
T38592 |
prep |
of,differentiation |
R11700 |
T38594 |
T38593 |
pobj |
RPCs,of |
R11701 |
T38595 |
T38592 |
prep |
into,differentiation |
R11702 |
T38596 |
T38595 |
pobj |
RTCs,into |
R11703 |
T38597 |
T38589 |
punct |
", ",required |
R11704 |
T38598 |
T38589 |
cc |
but,required |
R11705 |
T38599 |
T38589 |
conj |
is,required |
R11706 |
T38600 |
T38599 |
acomp |
essential,is |
R11707 |
T38601 |
T38602 |
aux |
to,couple |
R11708 |
T38602 |
T38599 |
advcl |
couple,is |
R11709 |
T38603 |
T38604 |
compound |
RTC,birth |
R11710 |
T38604 |
T38602 |
dobj |
birth,couple |
R11711 |
T38605 |
T38602 |
prep |
to,couple |
R11712 |
T38606 |
T38607 |
amod |
terminal,mitosis |
R11713 |
T38607 |
T38605 |
pobj |
mitosis,to |
R11714 |
T38608 |
T38602 |
punct |
", ",couple |
R11715 |
T38609 |
T38610 |
advmod |
thus,locking |
R11716 |
T38610 |
T38602 |
advcl |
locking,couple |
R11717 |
T38611 |
T38610 |
dobj |
them,locking |
R11718 |
T38612 |
T38613 |
advmod |
out,of |
R11719 |
T38613 |
T38610 |
oprd |
of,locking |
R11720 |
T38614 |
T38613 |
pobj |
cycle,of |
R11721 |
T38615 |
T38580 |
punct |
.,appear |
R11722 |
T38617 |
T38618 |
nsubj |
Rb,performs |
R11723 |
T38619 |
T38620 |
det |
this,function |
R11724 |
T38620 |
T38618 |
dobj |
function,performs |
R11725 |
T38621 |
T38618 |
prep |
by,performs |
R11726 |
T38622 |
T38621 |
pcomp |
inhibiting,by |
R11727 |
T38623 |
T38622 |
dobj |
E2f1,inhibiting |
R11728 |
T38624 |
T38618 |
punct |
.,performs |
R11729 |
T38626 |
T38627 |
nsubjpass |
Rb,required |
R11730 |
T38628 |
T38627 |
auxpass |
is,required |
R11731 |
T38629 |
T38627 |
advmod |
also,required |
R11732 |
T38630 |
T38627 |
prep |
for,required |
R11733 |
T38631 |
T38632 |
compound |
SAC,differentiation |
R11734 |
T38632 |
T38630 |
pobj |
differentiation,for |
R11735 |
T38633 |
T38627 |
punct |
", ",required |
R11736 |
T38634 |
T38627 |
cc |
and,required |
R11737 |
T38635 |
T38636 |
prep |
in,acts |
R11738 |
T38636 |
T38627 |
conj |
acts,required |
R11739 |
T38637 |
T38638 |
det |
this,case |
R11740 |
T38638 |
T38635 |
pobj |
case,in |
R11741 |
T38639 |
T38636 |
punct |
", ",acts |
R11742 |
T38640 |
T38636 |
prep |
by,acts |
R11743 |
T38641 |
T38640 |
pcomp |
inhibiting,by |
R11744 |
T38642 |
T38641 |
dobj |
E2f3a,inhibiting |
R11745 |
T38643 |
T38627 |
punct |
.,required |
R11746 |
T38645 |
T38646 |
expl |
There,is |
R11747 |
T38647 |
T38648 |
det |
no,evidence |
R11748 |
T38648 |
T38646 |
attr |
evidence,is |
R11749 |
T38649 |
T38648 |
amod |
direct,evidence |
R11750 |
T38650 |
T38651 |
mark |
that,required |
R11751 |
T38651 |
T38648 |
acl |
required,evidence |
R11752 |
T38652 |
T38651 |
nsubjpass |
Rb,required |
R11753 |
T38653 |
T38651 |
auxpass |
is,required |
R11754 |
T38654 |
T38651 |
prep |
for,required |
R11755 |
T38655 |
T38656 |
amod |
terminal,differentiation |
R11756 |
T38656 |
T38654 |
pobj |
differentiation,for |
R11757 |
T38657 |
T38656 |
prep |
of,differentiation |
R11758 |
T38658 |
T38659 |
amod |
other,types |
R11759 |
T38659 |
T38657 |
pobj |
types,of |
R11760 |
T38660 |
T38659 |
compound |
cell,types |
R11761 |
T38661 |
T38646 |
punct |
.,is |
R11762 |
T38663 |
T38664 |
compound |
Colour,codes |
R11763 |
T38665 |
T38664 |
cc |
and,codes |
R11764 |
T38666 |
T38664 |
conj |
abbreviations,codes |
R11765 |
T38667 |
T38664 |
prep |
as,codes |
R11766 |
T38668 |
T38667 |
prep |
in,as |
R11767 |
T38669 |
T38670 |
compound |
Figure,1A |
R11768 |
T38670 |
T38668 |
pobj |
1A,in |
R11769 |
T38671 |
T38664 |
punct |
.,codes |
R7272 |
T24763 |
T24745 |
conj |
proposed,contested |
R7273 |
T24764 |
T24765 |
punct |
[,63 |
R7274 |
T24765 |
T24763 |
parataxis |
63,proposed |
R7275 |
T24766 |
T24765 |
nummod |
62,63 |
R7276 |
T24767 |
T24765 |
punct |
",",63 |
R7277 |
T24768 |
T24765 |
punct |
],63 |
R7278 |
T24769 |
T24763 |
punct |
", ",proposed |
R7279 |
T24770 |
T24771 |
cc |
but,involving |
R7280 |
T24771 |
T24763 |
dep |
involving,proposed |
R7281 |
T24772 |
T24771 |
neg |
not,involving |
R7282 |
T24773 |
T24774 |
compound |
E2f,repression |
R7283 |
T24774 |
T24771 |
dobj |
repression,involving |
R7284 |
T24775 |
T24763 |
punct |
.,proposed |
R7285 |
T24777 |
T24778 |
advmod |
Strikingly,discovered |
R7286 |
T24779 |
T24778 |
punct |
", ",discovered |
R7287 |
T24780 |
T24778 |
advmod |
however,discovered |
R7288 |
T24781 |
T24778 |
punct |
", ",discovered |
R7289 |
T24782 |
T24778 |
nsubj |
we,discovered |
R7290 |
T24783 |
T24784 |
mark |
that,promotes |
R7291 |
T24784 |
T24778 |
ccomp |
promotes,discovered |
R7292 |
T24785 |
T24784 |
nsubj |
Rb,promotes |
R7293 |
T24786 |
T24787 |
compound |
SAC,differentiation |
R7294 |
T24787 |
T24784 |
dobj |
differentiation,promotes |
R7295 |
T24788 |
T24784 |
prep |
through,promotes |
R7296 |
T24789 |
T24788 |
pobj |
E2f3,through |
R7297 |
T24790 |
T24791 |
punct |
(,Figure |
R7298 |
T24791 |
T24784 |
parataxis |
Figure,promotes |
R7299 |
T24792 |
T24791 |
nummod |
8,Figure |
R7300 |
T24793 |
T24791 |
punct |
),Figure |
R7301 |
T24794 |
T24778 |
punct |
.,discovered |
R7302 |
T24803 |
T24804 |
amod |
a,"tes Distinct Processes through E2f1 and E2f3a
Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati" |
R7303 |
T24806 |
T24807 |
advmod |
o,f |
R7304 |
T24807 |
T24805 |
oprd |
f,on |
R7305 |
T24809 |
T24810 |
compound |
SAC,differentiation |
R7306 |
T24820 |
T24823 |
ccomp |
was,rescued |
R7390 |
T24912 |
T24911 |
prep |
of,subset |
R7391 |
T24913 |
T24914 |
compound |
CNS,neurons |
R7392 |
T24914 |
T24912 |
pobj |
neurons,of |
R7393 |
T24915 |
T24916 |
punct |
(,work |
R7394 |
T24916 |
T24907 |
parataxis |
work,expressed |
R7395 |
T24917 |
T24916 |
det |
this,work |
R7396 |
T24918 |
T24916 |
punct |
),work |
R7397 |
T24919 |
T24907 |
cc |
and,expressed |
R7398 |
T24920 |
T24907 |
conj |
drives,expressed |
R7399 |
T24921 |
T24922 |
amod |
specific,defects |
R7401 |
T24923 |
T24924 |
compound |
cell,cycle |