PMC:1914394 / 31088-31512 JSONTXT

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    craft-sa-dev

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quantified the fraction of Camk2a+ SACs in different genotypes and found that 60% of WT P30 Camk2a+ cells expressed Chat and Slc18a3, which dropped to only 5.6% in the Rb KO retina, and remained low at 3.7% in the Rb/E2f1 DKO retina, but rose to 91% in the Rb/E2f3 DKO retina (Figure 4B). The latter fraction is higher than WT because ganglion cells, which normally make up ~40% of Camk2a+ cells, are killed by apoptosis."}

    craft-ca-core-ex-dev

    {"project":"craft-ca-core-ex-dev","denotations":[{"id":"T16308","span":{"begin":30,"end":36},"obj":"PR_EXT:000003199"},{"id":"T16309","span":{"begin":56,"end":65},"obj":"SO_EXT:genotype_or_entity_with_genotype"},{"id":"T16310","span":{"begin":88,"end":90},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T16311","span":{"begin":95,"end":101},"obj":"PR_EXT:000003199"},{"id":"T16312","span":{"begin":103,"end":108},"obj":"CL_GO_EXT:cell"},{"id":"T16313","span":{"begin":109,"end":118},"obj":"GO:0010467"},{"id":"T16314","span":{"begin":119,"end":123},"obj":"GO_PR_EXT:choline_O_acetyltransferase"},{"id":"T16315","span":{"begin":128,"end":135},"obj":"PR_EXT:000014968"},{"id":"T16316","span":{"begin":171,"end":173},"obj":"PR_EXT:000013773"},{"id":"T16317","span":{"begin":177,"end":183},"obj":"UBERON:0000966"},{"id":"T16318","span":{"begin":217,"end":219},"obj":"PR_EXT:000013773"},{"id":"T16319","span":{"begin":220,"end":224},"obj":"PR_EXT:000006852"},{"id":"T16320","span":{"begin":229,"end":235},"obj":"UBERON:0000966"},{"id":"T16321","span":{"begin":260,"end":262},"obj":"PR_EXT:000013773"},{"id":"T16322","span":{"begin":263,"end":267},"obj":"PR_EXT:000006854"},{"id":"T16323","span":{"begin":272,"end":278},"obj":"UBERON:0000966"},{"id":"T16324","span":{"begin":327,"end":329},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T16325","span":{"begin":338,"end":346},"obj":"UBERON:0000045"},{"id":"T16326","span":{"begin":338,"end":352},"obj":"CL:0000740"},{"id":"T16327","span":{"begin":347,"end":352},"obj":"CL_GO_EXT:cell"},{"id":"T16328","span":{"begin":385,"end":391},"obj":"PR_EXT:000003199"},{"id":"T16329","span":{"begin":393,"end":398},"obj":"CL_GO_EXT:cell"},{"id":"T16330","span":{"begin":404,"end":410},"obj":"GO_EXT:killing"},{"id":"T16331","span":{"begin":414,"end":423},"obj":"GO:0006915"}],"text":"We quantified the fraction of Camk2a+ SACs in different genotypes and found that 60% of WT P30 Camk2a+ cells expressed Chat and Slc18a3, which dropped to only 5.6% in the Rb KO retina, and remained low at 3.7% in the Rb/E2f1 DKO retina, but rose to 91% in the Rb/E2f3 DKO retina (Figure 4B). The latter fraction is higher than WT because ganglion cells, which normally make up ~40% of Camk2a+ cells, are killed by apoptosis."}

    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T16169","span":{"begin":30,"end":36},"obj":"PR:000003199"},{"id":"T16170","span":{"begin":95,"end":101},"obj":"PR:000003199"},{"id":"T16171","span":{"begin":109,"end":118},"obj":"GO:0010467"},{"id":"T16172","span":{"begin":128,"end":135},"obj":"PR:000014968"},{"id":"T16173","span":{"begin":171,"end":173},"obj":"PR:000013773"},{"id":"T16174","span":{"begin":177,"end":183},"obj":"UBERON:0000966"},{"id":"T16175","span":{"begin":217,"end":219},"obj":"PR:000013773"},{"id":"T16176","span":{"begin":220,"end":224},"obj":"PR:000006852"},{"id":"T16177","span":{"begin":229,"end":235},"obj":"UBERON:0000966"},{"id":"T16178","span":{"begin":260,"end":262},"obj":"PR:000013773"},{"id":"T16179","span":{"begin":263,"end":267},"obj":"PR:000006854"},{"id":"T16180","span":{"begin":272,"end":278},"obj":"UBERON:0000966"},{"id":"T16181","span":{"begin":338,"end":346},"obj":"UBERON:0000045"},{"id":"T16182","span":{"begin":338,"end":352},"obj":"CL:0000740"},{"id":"T16183","span":{"begin":385,"end":391},"obj":"PR:000003199"},{"id":"T16184","span":{"begin":414,"end":423},"obj":"GO:0006915"}],"text":"We quantified the fraction of Camk2a+ SACs in different genotypes and found that 60% of WT P30 Camk2a+ cells expressed Chat and Slc18a3, which dropped to only 5.6% in the Rb KO retina, and remained low at 3.7% in the Rb/E2f1 DKO retina, but rose to 91% in the Rb/E2f3 DKO retina (Figure 4B). The latter fraction is higher than WT because ganglion cells, which normally make up ~40% of Camk2a+ cells, are killed by apoptosis."}