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The substantial reduction of both a- and b-waves is consistent with rod and bipolar cell apoptosis [2]. The sensitivity of the residual response appeared unchanged, suggesting it arose from the Cre-negative portions of the retina. Responses were about the same in the WT and E2f1 KO retina, and, most importantly, also the Rb/E2f1 DKO response median lay at the lower end of the normal range for most intensities (Figure 2F). Thus, E2f1 deletion almost completely rescued the rod system in the Rb KO retina."}

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{"project":"craft-ca-core-dev","denotations":[{"id":"T10835","span":{"begin":26,"end":38},"obj":"GO:1990603"},{"id":"T10836","span":{"begin":40,"end":48},"obj":"GO:1990603"},{"id":"T10837","span":{"begin":85,"end":88},"obj":"CL:0000604"},{"id":"T10838","span":{"begin":123,"end":125},"obj":"PR:000013773"},{"id":"T10839","span":{"begin":129,"end":135},"obj":"UBERON:0000966"},{"id":"T10840","span":{"begin":217,"end":220},"obj":"_FRAGMENT"},{"id":"T10841","span":{"begin":233,"end":237},"obj":"CL:0000604"},{"id":"T10842","span":{"begin":238,"end":247},"obj":"GO:0097473"},{"id":"T10843","span":{"begin":225,"end":237},"obj":"CL:0000103"},{"id":"T10844","span":{"begin":233,"end":247},"obj":"GO:0006915"},{"id":"T10845","span":{"begin":372,"end":378},"obj":"UBERON:0000966"},{"id":"T10846","span":{"begin":424,"end":428},"obj":"PR:000006852"},{"id":"T10847","span":{"begin":432,"end":438},"obj":"UBERON:0000966"},{"id":"T10848","span":{"begin":472,"end":474},"obj":"PR:000013773"},{"id":"T10849","span":{"begin":475,"end":479},"obj":"PR:000006852"},{"id":"T10850","span":{"begin":581,"end":585},"obj":"PR:000006852"},{"id":"T10851","span":{"begin":625,"end":628},"obj":"CL:0000604"},{"id":"T10852","span":{"begin":643,"end":645},"obj":"PR:000013773"},{"id":"T10853","span":{"begin":649,"end":655},"obj":"UBERON:0000966"}],"relations":[{"id":"R2931","pred":"_lexicallyChainedTo","subj":"T10841","obj":"T10840"},{"id":"R2932","pred":"_lexicallyChainedTo","subj":"T10842","obj":"T10840"}],"text":"Responses to dim light in dark-adapted (scotopic) conditions specifically assess the rod system, and were defective in the Rb KO retina (Figure 2E). The substantial reduction of both a- and b-waves is consistent with rod and bipolar cell apoptosis [2]. The sensitivity of the residual response appeared unchanged, suggesting it arose from the Cre-negative portions of the retina. Responses were about the same in the WT and E2f1 KO retina, and, most importantly, also the Rb/E2f1 DKO response median lay at the lower end of the normal range for most intensities (Figure 2F). Thus, E2f1 deletion almost completely rescued the rod system in the Rb KO retina."}

{"project":"2_test","denotations":[{"id":"17608565-15193257-84868980","span":{"begin":249,"end":250},"obj":"15193257"},{"id":"T23743","span":{"begin":249,"end":250},"obj":"15193257"}],"text":"Responses to dim light in dark-adapted (scotopic) conditions specifically assess the rod system, and were defective in the Rb KO retina (Figure 2E). The substantial reduction of both a- and b-waves is consistent with rod and bipolar cell apoptosis [2]. The sensitivity of the residual response appeared unchanged, suggesting it arose from the Cre-negative portions of the retina. Responses were about the same in the WT and E2f1 KO retina, and, most importantly, also the Rb/E2f1 DKO response median lay at the lower end of the normal range for most intensities (Figure 2F). Thus, E2f1 deletion almost completely rescued the rod system in the Rb KO retina."}