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discovery that E2f1 loss rescues even the morphology of Rb KO neurons is surprising because Rb is thought to regulate differentiation primarily through E2f-independent pathways [30–33]. However, normal morphology may not equate to completely normal differentiation. Thus, we compared the electroretinograms (ERGs) of adult WT (α-Cre), E2f1−/−, α-Cre;RbloxP/loxP, and α-Cre;RbloxP/loxP;E2f1−/− mice. ERGs functionally assess visual signalling in the mammalian retina from photoreceptors to amacrine cells (but usually not gangion cells), and are dominated by rod and cone bipolar cells. Typically, an ERG signal begins with a negative deflection initiated by the photoreceptors (the a-wave), which is terminated by a large positive deflection due to the activation of ON bipolar cells (the b-wave)."}

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{"project":"2_test","denotations":[{"id":"17608565-9420334-84868979","span":{"begin":182,"end":184},"obj":"9420334"},{"id":"17608565-8381715-84868979","span":{"begin":182,"end":184},"obj":"8381715"},{"id":"17608565-11545733-84868979","span":{"begin":182,"end":184},"obj":"11545733"},{"id":"17608565-8946919-84868979","span":{"begin":182,"end":184},"obj":"8946919"},{"id":"T28719","span":{"begin":182,"end":184},"obj":"9420334"},{"id":"T5228","span":{"begin":182,"end":184},"obj":"8381715"},{"id":"T83773","span":{"begin":182,"end":184},"obj":"11545733"},{"id":"T51839","span":{"begin":182,"end":184},"obj":"8946919"}],"text":"The discovery that E2f1 loss rescues even the morphology of Rb KO neurons is surprising because Rb is thought to regulate differentiation primarily through E2f-independent pathways [30–33]. However, normal morphology may not equate to completely normal differentiation. Thus, we compared the electroretinograms (ERGs) of adult WT (α-Cre), E2f1−/−, α-Cre;RbloxP/loxP, and α-Cre;RbloxP/loxP;E2f1−/− mice. ERGs functionally assess visual signalling in the mammalian retina from photoreceptors to amacrine cells (but usually not gangion cells), and are dominated by rod and cone bipolar cells. Typically, an ERG signal begins with a negative deflection initiated by the photoreceptors (the a-wave), which is terminated by a large positive deflection due to the activation of ON bipolar cells (the b-wave)."}