PMC:1914394 / 11631-16565 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T6888","span":{"begin":0,"end":2},"obj":"NN"},{"id":"T6889","span":{"begin":3,"end":12},"obj":"VBZ"},{"id":"T6890","span":{"begin":13,"end":21},"obj":"NN"},{"id":"T6891","span":{"begin":22,"end":25},"obj":"CC"},{"id":"T6892","span":{"begin":26,"end":31},"obj":"NN"},{"id":"T6893","span":{"begin":32,"end":39},"obj":"IN"},{"id":"T6894","span":{"begin":40,"end":44},"obj":"NN"},{"id":"T6895","span":{"begin":44,"end":150},"obj":"sentence"},{"id":"T6896","span":{"begin":45,"end":47},"obj":"PRP"},{"id":"T6897","span":{"begin":48,"end":52},"obj":"VBD"},{"id":"T6898","span":{"begin":53,"end":56},"obj":"DT"},{"id":"T6899","span":{"begin":63,"end":72},"obj":"NN"},{"id":"T6900","span":{"begin":57,"end":58},"obj":"NN"},{"id":"T6901","span":{"begin":59,"end":62},"obj":"NN"},{"id":"T6902","span":{"begin":58,"end":59},"obj":"HYPH"},{"id":"T6903","span":{"begin":73,"end":75},"obj":"TO"},{"id":"T6904","span":{"begin":76,"end":82},"obj":"VB"},{"id":"T6905","span":{"begin":83,"end":89},"obj":"VBN"},{"id":"T6906","span":{"begin":93,"end":97},"obj":"NN"},{"id":"T6907","span":{"begin":90,"end":92},"obj":"NN"},{"id":"T6908","span":{"begin":98,"end":100},"obj":"CD"},{"id":"T6909","span":{"begin":101,"end":103},"obj":"IN"},{"id":"T6910","span":{"begin":104,"end":113},"obj":"JJ"},{"id":"T6911","span":{"begin":114,"end":117},"obj":"NN"},{"id":"T6912","span":{"begin":118,"end":119},"obj":"-LRB-"},{"id":"T6913","span":{"begin":119,"end":120},"obj":"NN"},{"id":"T6914","span":{"begin":120,"end":121},"obj":"-RRB-"},{"id":"T6915","span":{"begin":122,"end":124},"obj":"CD"},{"id":"T6916","span":{"begin":125,"end":127},"obj":"IN"},{"id":"T6917","span":{"begin":128,"end":138},"obj":"JJ"},{"id":"T6918","span":{"begin":139,"end":145},"obj":"NN"},{"id":"T6919","span":{"begin":146,"end":147},"obj":"-LRB-"},{"id":"T6920","span":{"begin":147,"end":148},"obj":"CD"},{"id":"T6921","span":{"begin":148,"end":149},"obj":"-RRB-"},{"id":"T6922","span":{"begin":149,"end":150},"obj":"."},{"id":"T6923","span":{"begin":150,"end":282},"obj":"sentence"},{"id":"T6924","span":{"begin":151,"end":157},"obj":"NN"},{"id":"T6925","span":{"begin":158,"end":162},"obj":"NN"},{"id":"T6926","span":{"begin":157,"end":158},"obj":"HYPH"},{"id":"T6927","span":{"begin":169,"end":173},"obj":"NNS"},{"id":"T6928","span":{"begin":162,"end":163},"obj":":"},{"id":"T6929","span":{"begin":163,"end":164},"obj":"NN"},{"id":"T6930","span":{"begin":165,"end":168},"obj":"NN"},{"id":"T6931","span":{"begin":164,"end":165},"obj":"HYPH"},{"id":"T6932","span":{"begin":179,"end":183},"obj":"VBN"},{"id":"T6933","span":{"begin":174,"end":178},"obj":"VBD"},{"id":"T6934","span":{"begin":184,"end":188},"obj":"IN"},{"id":"T6935","span":{"begin":189,"end":196},"obj":"NNS"},{"id":"T6936","span":{"begin":197,"end":204},"obj":"VBG"},{"id":"T6937","span":{"begin":205,"end":209},"obj":"NN"},{"id":"T6938","span":{"begin":210,"end":212},"obj":"CC"},{"id":"T6939","span":{"begin":213,"end":217},"obj":"NN"},{"id":"T6940","span":{"begin":218,"end":220},"obj":"IN"},{"id":"T6941","span":{"begin":221,"end":224},"obj":"DT"},{"id":"T6942","span":{"begin":230,"end":234},"obj":"NN"},{"id":"T6943","span":{"begin":225,"end":229},"obj":"NN"},{"id":"T6944","span":{"begin":234,"end":236},"obj":","},{"id":"T6945","span":{"begin":236,"end":238},"obj":"CC"},{"id":"T6946","span":{"begin":239,"end":240},"obj":"DT"},{"id":"T6947","span":{"begin":241,"end":247},"obj":"NN"},{"id":"T6948","span":{"begin":248,"end":256},"obj":"VBG"},{"id":"T6949","span":{"begin":257,"end":258},"obj":"DT"},{"id":"T6950","span":{"begin":271,"end":277},"obj":"NN"},{"id":"T6951","span":{"begin":259,"end":265},"obj":"VBN"},{"id":"T6952","span":{"begin":266,"end":270},"obj":"NN"},{"id":"T6953","span":{"begin":278,"end":279},"obj":"-LRB-"},{"id":"T6954","span":{"begin":279,"end":280},"obj":"CD"},{"id":"T6955","span":{"begin":280,"end":281},"obj":"-RRB-"},{"id":"T6956","span":{"begin":281,"end":282},"obj":"."},{"id":"T6957","span":{"begin":282,"end":474},"obj":"sentence"},{"id":"T6958","span":{"begin":283,"end":289},"obj":"NN"},{"id":"T6959","span":{"begin":290,"end":294},"obj":"NN"},{"id":"T6960","span":{"begin":289,"end":290},"obj":"HYPH"},{"id":"T6961","span":{"begin":333,"end":337},"obj":"NNS"},{"id":"T6962","span":{"begin":294,"end":295},"obj":":"},{"id":"T6963","span":{"begin":295,"end":299},"obj":"NN"},{"id":"T6964","span":{"begin":299,"end":300},"obj":"SYM"},{"id":"T6965","span":{"begin":300,"end":301},"obj":"HYPH"},{"id":"T6966","span":{"begin":301,"end":302},"obj":"SYM"},{"id":"T6967","span":{"begin":303,"end":306},"obj":"CC"},{"id":"T6968","span":{"begin":307,"end":313},"obj":"NN"},{"id":"T6969","span":{"begin":314,"end":318},"obj":"NN"},{"id":"T6970","span":{"begin":313,"end":314},"obj":"HYPH"},{"id":"T6971","span":{"begin":318,"end":319},"obj":":"},{"id":"T6972","span":{"begin":319,"end":323},"obj":"NN"},{"id":"T6973","span":{"begin":323,"end":324},"obj":"SYM"},{"id":"T6974","span":{"begin":324,"end":325},"obj":"HYPH"},{"id":"T6975","span":{"begin":325,"end":326},"obj":"SYM"},{"id":"T6976","span":{"begin":326,"end":327},"obj":":"},{"id":"T6977","span":{"begin":327,"end":328},"obj":"NN"},{"id":"T6978","span":{"begin":329,"end":332},"obj":"NN"},{"id":"T6979","span":{"begin":328,"end":329},"obj":"HYPH"},{"id":"T6980","span":{"begin":343,"end":347},"obj":"VBN"},{"id":"T6981","span":{"begin":338,"end":342},"obj":"VBD"},{"id":"T6982","span":{"begin":348,"end":350},"obj":"TO"},{"id":"T6983","span":{"begin":351,"end":358},"obj":"VB"},{"id":"T6984","span":{"begin":359,"end":365},"obj":"NN"},{"id":"T6985","span":{"begin":366,"end":370},"obj":"NN"},{"id":"T6986","span":{"begin":365,"end":366},"obj":"HYPH"},{"id":"T6987","span":{"begin":385,"end":389},"obj":"NNS"},{"id":"T6988","span":{"begin":370,"end":371},"obj":":"},{"id":"T6989","span":{"begin":371,"end":375},"obj":"NN"},{"id":"T6990","span":{"begin":375,"end":376},"obj":"SYM"},{"id":"T6991","span":{"begin":376,"end":377},"obj":"HYPH"},{"id":"T6992","span":{"begin":377,"end":378},"obj":"SYM"},{"id":"T6993","span":{"begin":378,"end":379},"obj":":"},{"id":"T6994","span":{"begin":379,"end":380},"obj":"NN"},{"id":"T6995","span":{"begin":381,"end":384},"obj":"NN"},{"id":"T6996","span":{"begin":380,"end":381},"obj":"HYPH"},{"id":"T6997","span":{"begin":390,"end":392},"obj":"IN"},{"id":"T6998","span":{"begin":393,"end":394},"obj":"DT"},{"id":"T6999","span":{"begin":395,"end":404},"obj":"NN"},{"id":"T7000","span":{"begin":405,"end":407},"obj":"IN"},{"id":"T7001","span":{"begin":408,"end":409},"obj":"CD"},{"id":"T7002","span":{"begin":410,"end":411},"obj":"CD"},{"id":"T7003","span":{"begin":409,"end":410},"obj":"SYM"},{"id":"T7004","span":{"begin":412,"end":415},"obj":"CC"},{"id":"T7005","span":{"begin":416,"end":426},"obj":"NN"},{"id":"T7006","span":{"begin":427,"end":435},"obj":"NNS"},{"id":"T7007","span":{"begin":436,"end":438},"obj":"IN"},{"id":"T7008","span":{"begin":439,"end":442},"obj":"DT"},{"id":"T7009","span":{"begin":443,"end":447},"obj":"JJ"},{"id":"T7010","span":{"begin":448,"end":450},"obj":"CC"},{"id":"T7011","span":{"begin":451,"end":457},"obj":"JJR"},{"id":"T7012","span":{"begin":464,"end":473},"obj":"NN"},{"id":"T7013","span":{"begin":458,"end":459},"obj":"-LRB-"},{"id":"T7014","span":{"begin":459,"end":460},"obj":"CD"},{"id":"T7015","span":{"begin":460,"end":461},"obj":"SYM"},{"id":"T7016","span":{"begin":461,"end":462},"obj":"CD"},{"id":"T7017","span":{"begin":462,"end":463},"obj":"-RRB-"},{"id":"T7018","span":{"begin":473,"end":474},"obj":"."},{"id":"T7019","span":{"begin":474,"end":599},"obj":"sentence"},{"id":"T7020","span":{"begin":475,"end":478},"obj":"IN"},{"id":"T7021","span":{"begin":498,"end":503},"obj":"VB"},{"id":"T7022","span":{"begin":479,"end":489},"obj":"NN"},{"id":"T7023","span":{"begin":490,"end":492},"obj":"PRP"},{"id":"T7024","span":{"begin":493,"end":497},"obj":"MD"},{"id":"T7025","span":{"begin":504,"end":506},"obj":"IN"},{"id":"T7026","span":{"begin":507,"end":510},"obj":"DT"},{"id":"T7027","span":{"begin":548,"end":554},"obj":"NN"},{"id":"T7028","span":{"begin":511,"end":517},"obj":"NN"},{"id":"T7029","span":{"begin":518,"end":522},"obj":"NN"},{"id":"T7030","span":{"begin":517,"end":518},"obj":"HYPH"},{"id":"T7031","span":{"begin":522,"end":523},"obj":":"},{"id":"T7032","span":{"begin":523,"end":527},"obj":"NN"},{"id":"T7033","span":{"begin":527,"end":528},"obj":"SYM"},{"id":"T7034","span":{"begin":528,"end":529},"obj":"HYPH"},{"id":"T7035","span":{"begin":529,"end":530},"obj":"SYM"},{"id":"T7036","span":{"begin":530,"end":531},"obj":":"},{"id":"T7037","span":{"begin":531,"end":532},"obj":"NN"},{"id":"T7038","span":{"begin":533,"end":536},"obj":"NN"},{"id":"T7039","span":{"begin":532,"end":533},"obj":"HYPH"},{"id":"T7040","span":{"begin":537,"end":547},"obj":"JJ"},{"id":"T7041","span":{"begin":555,"end":557},"obj":"IN"},{"id":"T7042","span":{"begin":558,"end":561},"obj":"DT"},{"id":"T7043","span":{"begin":592,"end":598},"obj":"NN"},{"id":"T7044","span":{"begin":562,"end":564},"obj":"NN"},{"id":"T7045","span":{"begin":565,"end":569},"obj":"NN"},{"id":"T7046","span":{"begin":564,"end":565},"obj":"HYPH"},{"id":"T7047","span":{"begin":570,"end":576},"obj":"JJ"},{"id":"T7048","span":{"begin":577,"end":585},"obj":"NN"},{"id":"T7049","span":{"begin":586,"end":587},"obj":"-LRB-"},{"id":"T7050","span":{"begin":587,"end":590},"obj":"NN"},{"id":"T7051","span":{"begin":590,"end":591},"obj":"-RRB-"},{"id":"T7052","span":{"begin":598,"end":599},"obj":"."},{"id":"T7053","span":{"begin":599,"end":661},"obj":"sentence"},{"id":"T7054","span":{"begin":600,"end":607},"obj":"JJ"},{"id":"T7055","span":{"begin":608,"end":618},"obj":"NNS"},{"id":"T7056","span":{"begin":624,"end":632},"obj":"VBN"},{"id":"T7057","span":{"begin":619,"end":623},"obj":"VBD"},{"id":"T7058","span":{"begin":633,"end":635},"obj":"IN"},{"id":"T7059","span":{"begin":636,"end":639},"obj":"DT"},{"id":"T7060","span":{"begin":640,"end":644},"obj":"NN"},{"id":"T7061","span":{"begin":645,"end":647},"obj":"IN"},{"id":"T7062","span":{"begin":648,"end":652},"obj":"NN"},{"id":"T7063","span":{"begin":653,"end":655},"obj":"CC"},{"id":"T7064","span":{"begin":656,"end":660},"obj":"NN"},{"id":"T7065","span":{"begin":660,"end":661},"obj":"."},{"id":"T7066","span":{"begin":661,"end":772},"obj":"sentence"},{"id":"T7067","span":{"begin":662,"end":665},"obj":"NN"},{"id":"T7068","span":{"begin":666,"end":674},"obj":"VBN"},{"id":"T7069","span":{"begin":665,"end":666},"obj":"HYPH"},{"id":"T7070","span":{"begin":675,"end":683},"obj":"NN"},{"id":"T7071","span":{"begin":725,"end":734},"obj":"VBN"},{"id":"T7072","span":{"begin":684,"end":686},"obj":"IN"},{"id":"T7073","span":{"begin":687,"end":689},"obj":"NN"},{"id":"T7074","span":{"begin":699,"end":706},"obj":"NNS"},{"id":"T7075","span":{"begin":690,"end":693},"obj":"CC"},{"id":"T7076","span":{"begin":694,"end":698},"obj":"NN"},{"id":"T7077","span":{"begin":707,"end":709},"obj":"IN"},{"id":"T7078","span":{"begin":710,"end":713},"obj":"DT"},{"id":"T7079","span":{"begin":714,"end":720},"obj":"NN"},{"id":"T7080","span":{"begin":721,"end":724},"obj":"VBD"},{"id":"T7081","span":{"begin":735,"end":737},"obj":"IN"},{"id":"T7082","span":{"begin":738,"end":741},"obj":"NN"},{"id":"T7083","span":{"begin":742,"end":744},"obj":"IN"},{"id":"T7084","span":{"begin":745,"end":754},"obj":"VBN"},{"id":"T7085","span":{"begin":755,"end":765},"obj":"RB"},{"id":"T7086","span":{"begin":766,"end":767},"obj":"-LRB-"},{"id":"T7087","span":{"begin":769,"end":770},"obj":"CD"},{"id":"T7088","span":{"begin":767,"end":768},"obj":"CD"},{"id":"T7089","span":{"begin":768,"end":769},"obj":","},{"id":"T7090","span":{"begin":770,"end":771},"obj":"-RRB-"},{"id":"T7091","span":{"begin":771,"end":772},"obj":"."},{"id":"T7092","span":{"begin":772,"end":963},"obj":"sentence"},{"id":"T7093","span":{"begin":773,"end":775},"obj":"TO"},{"id":"T7094","span":{"begin":776,"end":783},"obj":"VB"},{"id":"T7095","span":{"begin":823,"end":831},"obj":"VBN"},{"id":"T7096","span":{"begin":784,"end":791},"obj":"JJ"},{"id":"T7097","span":{"begin":797,"end":805},"obj":"NN"},{"id":"T7098","span":{"begin":792,"end":796},"obj":"NN"},{"id":"T7099","span":{"begin":805,"end":807},"obj":","},{"id":"T7100","span":{"begin":807,"end":811},"obj":"NNS"},{"id":"T7101","span":{"begin":812,"end":816},"obj":"VBD"},{"id":"T7102","span":{"begin":817,"end":822},"obj":"NN"},{"id":"T7103","span":{"begin":822,"end":823},"obj":"HYPH"},{"id":"T7104","span":{"begin":832,"end":836},"obj":"IN"},{"id":"T7105","span":{"begin":837,"end":854},"obj":"NN"},{"id":"T7106","span":{"begin":855,"end":856},"obj":"-LRB-"},{"id":"T7107","span":{"begin":856,"end":860},"obj":"NN"},{"id":"T7108","span":{"begin":860,"end":861},"obj":"-RRB-"},{"id":"T7109","span":{"begin":862,"end":863},"obj":"CD"},{"id":"T7110","span":{"begin":864,"end":865},"obj":"NN"},{"id":"T7111","span":{"begin":866,"end":872},"obj":"IN"},{"id":"T7112","span":{"begin":873,"end":882},"obj":"NN"},{"id":"T7113","span":{"begin":883,"end":886},"obj":"CC"},{"id":"T7114","span":{"begin":887,"end":890},"obj":"DT"},{"id":"T7115","span":{"begin":902,"end":908},"obj":"NN"},{"id":"T7116","span":{"begin":891,"end":901},"obj":"JJ"},{"id":"T7117","span":{"begin":909,"end":917},"obj":"VBN"},{"id":"T7118","span":{"begin":918,"end":921},"obj":"IN"},{"id":"T7119","span":{"begin":922,"end":926},"obj":"NN"},{"id":"T7120","span":{"begin":927,"end":940},"obj":"NN"},{"id":"T7121","span":{"begin":941,"end":943},"obj":"IN"},{"id":"T7122","span":{"begin":944,"end":962},"obj":"NN"},{"id":"T7123","span":{"begin":962,"end":963},"obj":"."},{"id":"T7124","span":{"begin":963,"end":1083},"obj":"sentence"},{"id":"T7125","span":{"begin":964,"end":966},"obj":"IN"},{"id":"T7126","span":{"begin":967,"end":975},"obj":"VBN"},{"id":"T7127","span":{"begin":1004,"end":1013},"obj":"VBD"},{"id":"T7128","span":{"begin":976,"end":982},"obj":"RB"},{"id":"T7129","span":{"begin":983,"end":984},"obj":"-LRB-"},{"id":"T7130","span":{"begin":986,"end":987},"obj":"CD"},{"id":"T7131","span":{"begin":984,"end":985},"obj":"CD"},{"id":"T7132","span":{"begin":985,"end":986},"obj":","},{"id":"T7133","span":{"begin":987,"end":988},"obj":"-RRB-"},{"id":"T7134","span":{"begin":988,"end":990},"obj":"DT"},{"id":"T7135","span":{"begin":990,"end":992},"obj":"NN"},{"id":"T7136","span":{"begin":993,"end":995},"obj":"NN"},{"id":"T7137","span":{"begin":996,"end":1003},"obj":"NNS"},{"id":"T7138","span":{"begin":1014,"end":1018},"obj":"CC"},{"id":"T7139","span":{"begin":1019,"end":1026},"obj":"JJ"},{"id":"T7140","span":{"begin":1052,"end":1061},"obj":"NN"},{"id":"T7141","span":{"begin":1027,"end":1030},"obj":"CC"},{"id":"T7142","span":{"begin":1031,"end":1039},"obj":"JJ"},{"id":"T7143","span":{"begin":1040,"end":1047},"obj":"JJ"},{"id":"T7144","span":{"begin":1048,"end":1051},"obj":"NN"},{"id":"T7145","span":{"begin":1062,"end":1063},"obj":"-LRB-"},{"id":"T7146","span":{"begin":1071,"end":1073},"obj":"NN"},{"id":"T7147","span":{"begin":1063,"end":1070},"obj":"NNS"},{"id":"T7148","span":{"begin":1074,"end":1077},"obj":"CC"},{"id":"T7149","span":{"begin":1078,"end":1081},"obj":"NN"},{"id":"T7150","span":{"begin":1081,"end":1082},"obj":"-RRB-"},{"id":"T7151","span":{"begin":1082,"end":1083},"obj":"."},{"id":"T7152","span":{"begin":1083,"end":1342},"obj":"sentence"},{"id":"T7153","span":{"begin":1084,"end":1088},"obj":"DT"},{"id":"T7154","span":{"begin":1099,"end":1107},"obj":"VBN"},{"id":"T7155","span":{"begin":1089,"end":1091},"obj":"VBZ"},{"id":"T7156","span":{"begin":1092,"end":1098},"obj":"RB"},{"id":"T7157","span":{"begin":1108,"end":1110},"obj":"IN"},{"id":"T7158","span":{"begin":1111,"end":1114},"obj":"NN"},{"id":"T7159","span":{"begin":1114,"end":1116},"obj":","},{"id":"T7160","span":{"begin":1116,"end":1119},"obj":"NN"},{"id":"T7161","span":{"begin":1119,"end":1121},"obj":","},{"id":"T7162","span":{"begin":1121,"end":1124},"obj":"CC"},{"id":"T7163","span":{"begin":1125,"end":1134},"obj":"JJ"},{"id":"T7164","span":{"begin":1135,"end":1138},"obj":"NN"},{"id":"T7165","span":{"begin":1139,"end":1140},"obj":"-LRB-"},{"id":"T7166","span":{"begin":1140,"end":1141},"obj":"NN"},{"id":"T7167","span":{"begin":1141,"end":1142},"obj":"-RRB-"},{"id":"T7168","span":{"begin":1143,"end":1144},"obj":"CD"},{"id":"T7169","span":{"begin":1145,"end":1147},"obj":"IN"},{"id":"T7170","span":{"begin":1148,"end":1151},"obj":"DT"},{"id":"T7171","span":{"begin":1158,"end":1164},"obj":"NN"},{"id":"T7172","span":{"begin":1152,"end":1157},"obj":"JJ"},{"id":"T7173","span":{"begin":1165,"end":1170},"obj":"WRB"},{"id":"T7174","span":{"begin":1217,"end":1224},"obj":"VBN"},{"id":"T7175","span":{"begin":1171,"end":1179},"obj":"JJ"},{"id":"T7176","span":{"begin":1208,"end":1212},"obj":"NNS"},{"id":"T7177","span":{"begin":1180,"end":1184},"obj":"NN"},{"id":"T7178","span":{"begin":1184,"end":1185},"obj":"SYM"},{"id":"T7179","span":{"begin":1186,"end":1194},"obj":"NN"},{"id":"T7180","span":{"begin":1195,"end":1198},"obj":"CC"},{"id":"T7181","span":{"begin":1199,"end":1207},"obj":"JJ"},{"id":"T7182","span":{"begin":1213,"end":1216},"obj":"VBP"},{"id":"T7183","span":{"begin":1224,"end":1226},"obj":","},{"id":"T7184","span":{"begin":1226,"end":1228},"obj":"CC"},{"id":"T7185","span":{"begin":1229,"end":1231},"obj":"IN"},{"id":"T7186","span":{"begin":1232,"end":1235},"obj":"DT"},{"id":"T7187","span":{"begin":1246,"end":1252},"obj":"NN"},{"id":"T7188","span":{"begin":1236,"end":1245},"obj":"JJ"},{"id":"T7189","span":{"begin":1253,"end":1255},"obj":"IN"},{"id":"T7190","span":{"begin":1256,"end":1259},"obj":"DT"},{"id":"T7191","span":{"begin":1263,"end":1269},"obj":"NN"},{"id":"T7192","span":{"begin":1260,"end":1262},"obj":"NN"},{"id":"T7193","span":{"begin":1269,"end":1271},"obj":","},{"id":"T7194","span":{"begin":1271,"end":1276},"obj":"WRB"},{"id":"T7195","span":{"begin":1302,"end":1308},"obj":"VBP"},{"id":"T7196","span":{"begin":1277,"end":1281},"obj":"NN"},{"id":"T7197","span":{"begin":1297,"end":1301},"obj":"NNS"},{"id":"T7198","span":{"begin":1281,"end":1282},"obj":"SYM"},{"id":"T7199","span":{"begin":1283,"end":1296},"obj":"NN"},{"id":"T7200","span":{"begin":1309,"end":1310},"obj":"-LRB-"},{"id":"T7201","span":{"begin":1330,"end":1336},"obj":"NNS"},{"id":"T7202","span":{"begin":1310,"end":1317},"obj":"NNS"},{"id":"T7203","span":{"begin":1318,"end":1321},"obj":"NN"},{"id":"T7204","span":{"begin":1322,"end":1325},"obj":"CC"},{"id":"T7205","span":{"begin":1326,"end":1328},"obj":"NN"},{"id":"T7206","span":{"begin":1328,"end":1330},"obj":","},{"id":"T7207","span":{"begin":1336,"end":1337},"obj":"-RRB-"},{"id":"T7208","span":{"begin":1338,"end":1339},"obj":"-LRB-"},{"id":"T7209","span":{"begin":1339,"end":1340},"obj":"CD"},{"id":"T7210","span":{"begin":1340,"end":1341},"obj":"-RRB-"},{"id":"T7211","span":{"begin":1341,"end":1342},"obj":"."},{"id":"T7212","span":{"begin":1342,"end":1489},"obj":"sentence"},{"id":"T7213","span":{"begin":1343,"end":1350},"obj":"JJ"},{"id":"T7214","span":{"begin":1355,"end":1363},"obj":"NN"},{"id":"T7215","span":{"begin":1351,"end":1354},"obj":"NN"},{"id":"T7216","span":{"begin":1381,"end":1383},"obj":"VBZ"},{"id":"T7217","span":{"begin":1364,"end":1366},"obj":"IN"},{"id":"T7218","span":{"begin":1367,"end":1369},"obj":"NN"},{"id":"T7219","span":{"begin":1370,"end":1372},"obj":"NN"},{"id":"T7220","span":{"begin":1373,"end":1380},"obj":"NNS"},{"id":"T7221","span":{"begin":1384,"end":1388},"obj":"RB"},{"id":"T7222","span":{"begin":1389,"end":1393},"obj":"RBR"},{"id":"T7223","span":{"begin":1394,"end":1401},"obj":"JJ"},{"id":"T7224","span":{"begin":1402,"end":1404},"obj":"IN"},{"id":"T7225","span":{"begin":1405,"end":1407},"obj":"NN"},{"id":"T7226","span":{"begin":1408,"end":1410},"obj":"CC"},{"id":"T7227","span":{"begin":1411,"end":1414},"obj":"NN"},{"id":"T7228","span":{"begin":1414,"end":1416},"obj":","},{"id":"T7229","span":{"begin":1416,"end":1420},"obj":"WRB"},{"id":"T7230","span":{"begin":1433,"end":1442},"obj":"VBN"},{"id":"T7231","span":{"begin":1421,"end":1429},"obj":"NN"},{"id":"T7232","span":{"begin":1430,"end":1432},"obj":"VBZ"},{"id":"T7233","span":{"begin":1443,"end":1445},"obj":"IN"},{"id":"T7234","span":{"begin":1446,"end":1450},"obj":"JJ"},{"id":"T7235","span":{"begin":1451,"end":1455},"obj":"NN"},{"id":"T7236","span":{"begin":1450,"end":1451},"obj":"HYPH"},{"id":"T7237","span":{"begin":1461,"end":1467},"obj":"NN"},{"id":"T7238","span":{"begin":1456,"end":1457},"obj":"-LRB-"},{"id":"T7239","span":{"begin":1457,"end":1459},"obj":"NN"},{"id":"T7240","span":{"begin":1459,"end":1460},"obj":"-RRB-"},{"id":"T7241","span":{"begin":1468,"end":1469},"obj":"-LRB-"},{"id":"T7242","span":{"begin":1477,"end":1479},"obj":"NN"},{"id":"T7243","span":{"begin":1469,"end":1476},"obj":"NNS"},{"id":"T7244","span":{"begin":1480,"end":1483},"obj":"CC"},{"id":"T7245","span":{"begin":1484,"end":1487},"obj":"NN"},{"id":"T7246","span":{"begin":1487,"end":1488},"obj":"-RRB-"},{"id":"T7247","span":{"begin":1488,"end":1489},"obj":"."},{"id":"T7248","span":{"begin":1489,"end":1694},"obj":"sentence"},{"id":"T7249","span":{"begin":1490,"end":1500},"obj":"RB"},{"id":"T7250","span":{"begin":1623,"end":1633},"obj":"VBN"},{"id":"T7251","span":{"begin":1500,"end":1502},"obj":","},{"id":"T7252","span":{"begin":1502,"end":1505},"obj":"DT"},{"id":"T7253","span":{"begin":1537,"end":1542},"obj":"NNS"},{"id":"T7254","span":{"begin":1506,"end":1517},"obj":"RB"},{"id":"T7255","span":{"begin":1518,"end":1528},"obj":"VBN"},{"id":"T7256","span":{"begin":1529,"end":1530},"obj":"NN"},{"id":"T7257","span":{"begin":1531,"end":1536},"obj":"NN"},{"id":"T7258","span":{"begin":1530,"end":1531},"obj":"HYPH"},{"id":"T7259","span":{"begin":1543,"end":1545},"obj":"IN"},{"id":"T7260","span":{"begin":1546,"end":1549},"obj":"NN"},{"id":"T7261","span":{"begin":1549,"end":1551},"obj":","},{"id":"T7262","span":{"begin":1551,"end":1554},"obj":"NN"},{"id":"T7263","span":{"begin":1554,"end":1556},"obj":","},{"id":"T7264","span":{"begin":1556,"end":1559},"obj":"CC"},{"id":"T7265","span":{"begin":1560,"end":1562},"obj":"NN"},{"id":"T7266","span":{"begin":1563,"end":1566},"obj":"CC"},{"id":"T7267","span":{"begin":1567,"end":1570},"obj":"PDT"},{"id":"T7268","span":{"begin":1584,"end":1592},"obj":"NN"},{"id":"T7269","span":{"begin":1571,"end":1574},"obj":"DT"},{"id":"T7270","span":{"begin":1575,"end":1583},"obj":"JJ"},{"id":"T7271","span":{"begin":1593,"end":1595},"obj":"IN"},{"id":"T7272","span":{"begin":1596,"end":1598},"obj":"NN"},{"id":"T7273","span":{"begin":1599,"end":1602},"obj":"CC"},{"id":"T7274","span":{"begin":1603,"end":1606},"obj":"NN"},{"id":"T7275","span":{"begin":1607,"end":1611},"obj":"VBD"},{"id":"T7276","span":{"begin":1612,"end":1622},"obj":"RB"},{"id":"T7277","span":{"begin":1634,"end":1636},"obj":"IN"},{"id":"T7278","span":{"begin":1637,"end":1640},"obj":"DT"},{"id":"T7279","span":{"begin":1653,"end":1659},"obj":"NN"},{"id":"T7280","span":{"begin":1641,"end":1643},"obj":"NN"},{"id":"T7281","span":{"begin":1644,"end":1648},"obj":"NN"},{"id":"T7282","span":{"begin":1643,"end":1644},"obj":"HYPH"},{"id":"T7283","span":{"begin":1649,"end":1652},"obj":"NN"},{"id":"T7284","span":{"begin":1660,"end":1661},"obj":"-LRB-"},{"id":"T7285","span":{"begin":1669,"end":1671},"obj":"NN"},{"id":"T7286","span":{"begin":1661,"end":1668},"obj":"NNS"},{"id":"T7287","span":{"begin":1671,"end":1673},"obj":","},{"id":"T7288","span":{"begin":1673,"end":1675},"obj":"NN"},{"id":"T7289","span":{"begin":1675,"end":1677},"obj":","},{"id":"T7290","span":{"begin":1677,"end":1679},"obj":"NN"},{"id":"T7291","span":{"begin":1679,"end":1681},"obj":","},{"id":"T7292","span":{"begin":1681,"end":1684},"obj":"NN"},{"id":"T7293","span":{"begin":1684,"end":1686},"obj":","},{"id":"T7294","span":{"begin":1686,"end":1689},"obj":"CC"},{"id":"T7295","span":{"begin":1690,"end":1692},"obj":"NN"},{"id":"T7296","span":{"begin":1692,"end":1693},"obj":"-RRB-"},{"id":"T7297","span":{"begin":1693,"end":1694},"obj":"."},{"id":"T7298","span":{"begin":1694,"end":1775},"obj":"sentence"},{"id":"T7299","span":{"begin":1695,"end":1697},"obj":"IN"},{"id":"T7300","span":{"begin":1733,"end":1736},"obj":"VBD"},{"id":"T7301","span":{"begin":1698,"end":1706},"obj":"NN"},{"id":"T7302","span":{"begin":1706,"end":1708},"obj":","},{"id":"T7303","span":{"begin":1708,"end":1716},"obj":"NN"},{"id":"T7304","span":{"begin":1717,"end":1719},"obj":"IN"},{"id":"T7305","span":{"begin":1720,"end":1724},"obj":"NN"},{"id":"T7306","span":{"begin":1725,"end":1727},"obj":"CC"},{"id":"T7307","span":{"begin":1728,"end":1732},"obj":"NN"},{"id":"T7308","span":{"begin":1737,"end":1739},"obj":"DT"},{"id":"T7309","span":{"begin":1740,"end":1746},"obj":"NN"},{"id":"T7310","span":{"begin":1747,"end":1749},"obj":"IN"},{"id":"T7311","span":{"begin":1750,"end":1753},"obj":"DT"},{"id":"T7312","span":{"begin":1754,"end":1759},"obj":"NN"},{"id":"T7313","span":{"begin":1760,"end":1762},"obj":"IN"},{"id":"T7314","span":{"begin":1763,"end":1774},"obj":"NN"},{"id":"T7315","span":{"begin":1774,"end":1775},"obj":"."},{"id":"T7316","span":{"begin":1775,"end":1946},"obj":"sentence"},{"id":"T7317","span":{"begin":1776,"end":1784},"obj":"NN"},{"id":"T7318","span":{"begin":1855,"end":1864},"obj":"VBD"},{"id":"T7319","span":{"begin":1785,"end":1787},"obj":"IN"},{"id":"T7320","span":{"begin":1788,"end":1795},"obj":"JJ"},{"id":"T7321","span":{"begin":1796,"end":1801},"obj":"NNS"},{"id":"T7322","span":{"begin":1802,"end":1806},"obj":"IN"},{"id":"T7323","span":{"begin":1807,"end":1826},"obj":"NN"},{"id":"T7324","span":{"begin":1835,"end":1843},"obj":"JJ"},{"id":"T7325","span":{"begin":1827,"end":1828},"obj":"CD"},{"id":"T7326","span":{"begin":1829,"end":1830},"obj":"-LRB-"},{"id":"T7327","span":{"begin":1830,"end":1833},"obj":"NN"},{"id":"T7328","span":{"begin":1833,"end":1834},"obj":"-RRB-"},{"id":"T7329","span":{"begin":1834,"end":1835},"obj":"HYPH"},{"id":"T7330","span":{"begin":1844,"end":1854},"obj":"NNS"},{"id":"T7331","span":{"begin":1865,"end":1869},"obj":"IN"},{"id":"T7332","span":{"begin":1906,"end":1916},"obj":"VBD"},{"id":"T7333","span":{"begin":1870,"end":1874},"obj":"NN"},{"id":"T7334","span":{"begin":1875,"end":1877},"obj":"IN"},{"id":"T7335","span":{"begin":1878,"end":1882},"obj":"NN"},{"id":"T7336","span":{"begin":1882,"end":1884},"obj":","},{"id":"T7337","span":{"begin":1884,"end":1887},"obj":"CC"},{"id":"T7338","span":{"begin":1888,"end":1891},"obj":"RB"},{"id":"T7339","span":{"begin":1892,"end":1896},"obj":"NN"},{"id":"T7340","span":{"begin":1897,"end":1899},"obj":"CC"},{"id":"T7341","span":{"begin":1900,"end":1904},"obj":"NN"},{"id":"T7342","span":{"begin":1904,"end":1906},"obj":","},{"id":"T7343","span":{"begin":1917,"end":1924},"obj":"JJ"},{"id":"T7344","span":{"begin":1925,"end":1933},"obj":"NN"},{"id":"T7345","span":{"begin":1934,"end":1935},"obj":"-LRB-"},{"id":"T7346","span":{"begin":1942,"end":1944},"obj":"NN"},{"id":"T7347","span":{"begin":1935,"end":1941},"obj":"NN"},{"id":"T7348","span":{"begin":1944,"end":1945},"obj":"-RRB-"},{"id":"T7349","span":{"begin":1945,"end":1946},"obj":"."},{"id":"T7350","span":{"begin":1946,"end":2161},"obj":"sentence"},{"id":"T7351","span":{"begin":1947,"end":1955},"obj":"VBG"},{"id":"T7352","span":{"begin":1982,"end":1992},"obj":"VBD"},{"id":"T7353","span":{"begin":1956,"end":1959},"obj":"CD"},{"id":"T7354","span":{"begin":1965,"end":1971},"obj":"NN"},{"id":"T7355","span":{"begin":1960,"end":1964},"obj":"NN"},{"id":"T7356","span":{"begin":1972,"end":1981},"obj":"RB"},{"id":"T7357","span":{"begin":1993,"end":2000},"obj":"JJ"},{"id":"T7358","span":{"begin":2003,"end":2008},"obj":"NN"},{"id":"T7359","span":{"begin":2001,"end":2002},"obj":"NN"},{"id":"T7360","span":{"begin":2002,"end":2003},"obj":"HYPH"},{"id":"T7361","span":{"begin":2009,"end":2012},"obj":"CC"},{"id":"T7362","span":{"begin":2013,"end":2020},"obj":"NN"},{"id":"T7363","span":{"begin":2021,"end":2023},"obj":"IN"},{"id":"T7364","span":{"begin":2024,"end":2026},"obj":"NN"},{"id":"T7365","span":{"begin":2027,"end":2029},"obj":"NN"},{"id":"T7366","span":{"begin":2030,"end":2034},"obj":"NNS"},{"id":"T7367","span":{"begin":2035,"end":2036},"obj":"-LRB-"},{"id":"T7368","span":{"begin":2044,"end":2046},"obj":"NN"},{"id":"T7369","span":{"begin":2036,"end":2043},"obj":"NNS"},{"id":"T7370","span":{"begin":2046,"end":2048},"obj":","},{"id":"T7371","span":{"begin":2048,"end":2050},"obj":"NN"},{"id":"T7372","span":{"begin":2050,"end":2052},"obj":","},{"id":"T7373","span":{"begin":2052,"end":2054},"obj":"NN"},{"id":"T7374","span":{"begin":2054,"end":2056},"obj":","},{"id":"T7375","span":{"begin":2056,"end":2059},"obj":"NN"},{"id":"T7376","span":{"begin":2059,"end":2061},"obj":","},{"id":"T7377","span":{"begin":2061,"end":2063},"obj":"NN"},{"id":"T7378","span":{"begin":2063,"end":2065},"obj":","},{"id":"T7379","span":{"begin":2065,"end":2068},"obj":"CC"},{"id":"T7380","span":{"begin":2069,"end":2071},"obj":"NN"},{"id":"T7381","span":{"begin":2071,"end":2072},"obj":"-RRB-"},{"id":"T7382","span":{"begin":2072,"end":2074},"obj":","},{"id":"T7383","span":{"begin":2074,"end":2084},"obj":"VBG"},{"id":"T7384","span":{"begin":2085,"end":2089},"obj":"IN"},{"id":"T7385","span":{"begin":2095,"end":2101},"obj":"VBZ"},{"id":"T7386","span":{"begin":2090,"end":2094},"obj":"NN"},{"id":"T7387","span":{"begin":2102,"end":2109},"obj":"JJ"},{"id":"T7388","span":{"begin":2110,"end":2118},"obj":"NN"},{"id":"T7389","span":{"begin":2119,"end":2121},"obj":"IN"},{"id":"T7390","span":{"begin":2122,"end":2124},"obj":"NN"},{"id":"T7391","span":{"begin":2125,"end":2127},"obj":"NN"},{"id":"T7392","span":{"begin":2128,"end":2132},"obj":"NNS"},{"id":"T7393","span":{"begin":2133,"end":2135},"obj":"IN"},{"id":"T7394","span":{"begin":2136,"end":2137},"obj":"DT"},{"id":"T7395","span":{"begin":2153,"end":2160},"obj":"NN"},{"id":"T7396","span":{"begin":2138,"end":2142},"obj":"NN"},{"id":"T7397","span":{"begin":2143,"end":2152},"obj":"JJ"},{"id":"T7398","span":{"begin":2142,"end":2143},"obj":"HYPH"},{"id":"T7399","span":{"begin":2160,"end":2161},"obj":"."},{"id":"T7400","span":{"begin":2161,"end":2329},"obj":"sentence"},{"id":"T7401","span":{"begin":2162,"end":2167},"obj":"DT"},{"id":"T7402","span":{"begin":2168,"end":2172},"obj":"NNS"},{"id":"T7403","span":{"begin":2173,"end":2181},"obj":"VBP"},{"id":"T7404","span":{"begin":2182,"end":2186},"obj":"IN"},{"id":"T7405","span":{"begin":2187,"end":2195},"obj":"JJ"},{"id":"T7406","span":{"begin":2196,"end":2204},"obj":"NNS"},{"id":"T7407","span":{"begin":2205,"end":2207},"obj":"IN"},{"id":"T7408","span":{"begin":2208,"end":2211},"obj":"DT"},{"id":"T7409","span":{"begin":2212,"end":2216},"obj":"NN"},{"id":"T7410","span":{"begin":2217,"end":2220},"obj":"CC"},{"id":"T7411","span":{"begin":2221,"end":2224},"obj":"NN"},{"id":"T7412","span":{"begin":2225,"end":2227},"obj":"IN"},{"id":"T7413","span":{"begin":2228,"end":2230},"obj":"NN"},{"id":"T7414","span":{"begin":2231,"end":2233},"obj":"NN"},{"id":"T7415","span":{"begin":2234,"end":2241},"obj":"NNS"},{"id":"T7416","span":{"begin":2241,"end":2243},"obj":","},{"id":"T7417","span":{"begin":2243,"end":2248},"obj":"WRB"},{"id":"T7418","span":{"begin":2280,"end":2290},"obj":"VBZ"},{"id":"T7419","span":{"begin":2249,"end":2257},"obj":"NN"},{"id":"T7420","span":{"begin":2258,"end":2260},"obj":"IN"},{"id":"T7421","span":{"begin":2261,"end":2264},"obj":"DT"},{"id":"T7422","span":{"begin":2276,"end":2279},"obj":"NN"},{"id":"T7423","span":{"begin":2265,"end":2275},"obj":"VBG"},{"id":"T7424","span":{"begin":2291,"end":2298},"obj":"JJ"},{"id":"T7425","span":{"begin":2299,"end":2307},"obj":"NN"},{"id":"T7426","span":{"begin":2308,"end":2310},"obj":"IN"},{"id":"T7427","span":{"begin":2311,"end":2315},"obj":"DT"},{"id":"T7428","span":{"begin":2316,"end":2322},"obj":"NN"},{"id":"T7429","span":{"begin":2323,"end":2324},"obj":"-LRB-"},{"id":"T7430","span":{"begin":2324,"end":2325},"obj":"CD"},{"id":"T7431","span":{"begin":2325,"end":2326},"obj":"SYM"},{"id":"T7432","span":{"begin":2326,"end":2327},"obj":"CD"},{"id":"T7433","span":{"begin":2327,"end":2328},"obj":"-RRB-"},{"id":"T7434","span":{"begin":2328,"end":2329},"obj":"."},{"id":"T7435","span":{"begin":2329,"end":2480},"obj":"sentence"},{"id":"T7436","span":{"begin":2330,"end":2334},"obj":"NN"},{"id":"T7437","span":{"begin":2355,"end":2362},"obj":"VBZ"},{"id":"T7438","span":{"begin":2335,"end":2337},"obj":"IN"},{"id":"T7439","span":{"begin":2338,"end":2340},"obj":"NN"},{"id":"T7440","span":{"begin":2341,"end":2343},"obj":"IN"},{"id":"T7441","span":{"begin":2344,"end":2347},"obj":"DT"},{"id":"T7442","span":{"begin":2348,"end":2354},"obj":"NN"},{"id":"T7443","span":{"begin":2363,"end":2365},"obj":"IN"},{"id":"T7444","span":{"begin":2366,"end":2378},"obj":"JJ"},{"id":"T7445","span":{"begin":2383,"end":2392},"obj":"NN"},{"id":"T7446","span":{"begin":2379,"end":2382},"obj":"NN"},{"id":"T7447","span":{"begin":2392,"end":2394},"obj":","},{"id":"T7448","span":{"begin":2394,"end":2405},"obj":"VBG"},{"id":"T7449","span":{"begin":2406,"end":2410},"obj":"JJS"},{"id":"T7450","span":{"begin":2432,"end":2437},"obj":"NNS"},{"id":"T7451","span":{"begin":2411,"end":2418},"obj":"JJ"},{"id":"T7452","span":{"begin":2419,"end":2422},"obj":"CC"},{"id":"T7453","span":{"begin":2423,"end":2431},"obj":"NN"},{"id":"T7454","span":{"begin":2438,"end":2440},"obj":"RB"},{"id":"T7455","span":{"begin":2446,"end":2448},"obj":"IN"},{"id":"T7456","span":{"begin":2441,"end":2445},"obj":"RB"},{"id":"T7457","span":{"begin":2449,"end":2453},"obj":"JJ"},{"id":"T7458","span":{"begin":2454,"end":2458},"obj":"NNS"},{"id":"T7459","span":{"begin":2459,"end":2460},"obj":"-LRB-"},{"id":"T7460","span":{"begin":2467,"end":2469},"obj":"NN"},{"id":"T7461","span":{"begin":2460,"end":2466},"obj":"NN"},{"id":"T7462","span":{"begin":2469,"end":2470},"obj":"SYM"},{"id":"T7463","span":{"begin":2470,"end":2472},"obj":"NN"},{"id":"T7464","span":{"begin":2472,"end":2473},"obj":"-RRB-"},{"id":"T7465","span":{"begin":2474,"end":2475},"obj":"-LRB-"},{"id":"T7466","span":{"begin":2477,"end":2478},"obj":"CD"},{"id":"T7467","span":{"begin":2475,"end":2476},"obj":"CD"},{"id":"T7468","span":{"begin":2476,"end":2477},"obj":","},{"id":"T7469","span":{"begin":2478,"end":2479},"obj":"-RRB-"},{"id":"T7470","span":{"begin":2479,"end":2480},"obj":"."},{"id":"T7471","span":{"begin":2480,"end":2736},"obj":"sentence"},{"id":"T7472","span":{"begin":2481,"end":2484},"obj":"DT"},{"id":"T7473","span":{"begin":2485,"end":2489},"obj":"NN"},{"id":"T7474","span":{"begin":2504,"end":2506},"obj":"VBZ"},{"id":"T7475","span":{"begin":2490,"end":2492},"obj":"IN"},{"id":"T7476","span":{"begin":2493,"end":2495},"obj":"NN"},{"id":"T7477","span":{"begin":2496,"end":2498},"obj":"NN"},{"id":"T7478","span":{"begin":2499,"end":2503},"obj":"NNS"},{"id":"T7479","span":{"begin":2507,"end":2514},"obj":"JJ"},{"id":"T7480","span":{"begin":2515,"end":2519},"obj":"IN"},{"id":"T7481","span":{"begin":2520,"end":2523},"obj":"DT"},{"id":"T7482","span":{"begin":2532,"end":2535},"obj":"NN"},{"id":"T7483","span":{"begin":2524,"end":2531},"obj":"JJ"},{"id":"T7484","span":{"begin":2535,"end":2537},"obj":","},{"id":"T7485","span":{"begin":2537,"end":2540},"obj":"CC"},{"id":"T7486","span":{"begin":2541,"end":2544},"obj":"DT"},{"id":"T7487","span":{"begin":2545,"end":2550},"obj":"NN"},{"id":"T7488","span":{"begin":2613,"end":2621},"obj":"VBN"},{"id":"T7489","span":{"begin":2551,"end":2553},"obj":"IN"},{"id":"T7490","span":{"begin":2554,"end":2559},"obj":"DT"},{"id":"T7491","span":{"begin":2560,"end":2565},"obj":"NNS"},{"id":"T7492","span":{"begin":2566,"end":2568},"obj":"RB"},{"id":"T7493","span":{"begin":2574,"end":2576},"obj":"IN"},{"id":"T7494","span":{"begin":2569,"end":2573},"obj":"RB"},{"id":"T7495","span":{"begin":2577,"end":2584},"obj":"JJ"},{"id":"T7496","span":{"begin":2598,"end":2605},"obj":"NNS"},{"id":"T7497","span":{"begin":2585,"end":2588},"obj":"CC"},{"id":"T7498","span":{"begin":2589,"end":2597},"obj":"NN"},{"id":"T7499","span":{"begin":2606,"end":2609},"obj":"MD"},{"id":"T7500","span":{"begin":2610,"end":2612},"obj":"VB"},{"id":"T7501","span":{"begin":2622,"end":2630},"obj":"RB"},{"id":"T7502","span":{"begin":2631,"end":2633},"obj":"IN"},{"id":"T7503","span":{"begin":2634,"end":2640},"obj":"RB"},{"id":"T7504","span":{"begin":2641,"end":2650},"obj":"VBG"},{"id":"T7505","span":{"begin":2651,"end":2654},"obj":"IN"},{"id":"T7506","span":{"begin":2655,"end":2664},"obj":"JJ"},{"id":"T7507","span":{"begin":2688,"end":2695},"obj":"NNS"},{"id":"T7508","span":{"begin":2665,"end":2668},"obj":"CC"},{"id":"T7509","span":{"begin":2669,"end":2673},"obj":"NN"},{"id":"T7510","span":{"begin":2674,"end":2678},"obj":"NN"},{"id":"T7511","span":{"begin":2673,"end":2674},"obj":"HYPH"},{"id":"T7512","span":{"begin":2679,"end":2687},"obj":"JJ"},{"id":"T7513","span":{"begin":2678,"end":2679},"obj":"HYPH"},{"id":"T7514","span":{"begin":2696,"end":2697},"obj":"-LRB-"},{"id":"T7515","span":{"begin":2697,"end":2698},"obj":"CD"},{"id":"T7516","span":{"begin":2698,"end":2699},"obj":"-RRB-"},{"id":"T7517","span":{"begin":2700,"end":2701},"obj":"-LRB-"},{"id":"T7518","span":{"begin":2701,"end":2703},"obj":"NNP"},{"id":"T7519","span":{"begin":2704,"end":2706},"obj":"NNP"},{"id":"T7520","span":{"begin":2707,"end":2710},"obj":"CC"},{"id":"T7521","span":{"begin":2711,"end":2713},"obj":"NNP"},{"id":"T7522","span":{"begin":2714,"end":2716},"obj":"NNP"},{"id":"T7523","span":{"begin":2716,"end":2718},"obj":","},{"id":"T7524","span":{"begin":2718,"end":2729},"obj":"JJ"},{"id":"T7525","span":{"begin":2730,"end":2734},"obj":"NNS"},{"id":"T7526","span":{"begin":2734,"end":2735},"obj":"-RRB-"},{"id":"T7527","span":{"begin":2735,"end":2736},"obj":"."},{"id":"T7528","span":{"begin":2736,"end":2862},"obj":"sentence"},{"id":"T7529","span":{"begin":2737,"end":2741},"obj":"NN"},{"id":"T7530","span":{"begin":2777,"end":2779},"obj":"VBZ"},{"id":"T7531","span":{"begin":2742,"end":2744},"obj":"IN"},{"id":"T7532","span":{"begin":2745,"end":2755},"obj":"JJ"},{"id":"T7533","span":{"begin":2771,"end":2776},"obj":"NNS"},{"id":"T7534","span":{"begin":2756,"end":2758},"obj":"NN"},{"id":"T7535","span":{"begin":2759,"end":2761},"obj":"NN"},{"id":"T7536","span":{"begin":2762,"end":2770},"obj":"NN"},{"id":"T7537","span":{"begin":2780,"end":2784},"obj":"RB"},{"id":"T7538","span":{"begin":2785,"end":2792},"obj":"JJ"},{"id":"T7539","span":{"begin":2793,"end":2797},"obj":"IN"},{"id":"T7540","span":{"begin":2798,"end":2806},"obj":"VBG"},{"id":"T7541","span":{"begin":2807,"end":2809},"obj":"IN"},{"id":"T7542","span":{"begin":2810,"end":2813},"obj":"DT"},{"id":"T7543","span":{"begin":2820,"end":2825},"obj":"NN"},{"id":"T7544","span":{"begin":2814,"end":2819},"obj":"JJ"},{"id":"T7545","span":{"begin":2826,"end":2827},"obj":"-LRB-"},{"id":"T7546","span":{"begin":2827,"end":2829},"obj":"NNP"},{"id":"T7547","span":{"begin":2830,"end":2832},"obj":"NNP"},{"id":"T7548","span":{"begin":2833,"end":2836},"obj":"CC"},{"id":"T7549","span":{"begin":2837,"end":2839},"obj":"NNP"},{"id":"T7550","span":{"begin":2840,"end":2842},"obj":"NNP"},{"id":"T7551","span":{"begin":2842,"end":2844},"obj":","},{"id":"T7552","span":{"begin":2844,"end":2855},"obj":"JJ"},{"id":"T7553","span":{"begin":2856,"end":2860},"obj":"NNS"},{"id":"T7554","span":{"begin":2860,"end":2861},"obj":"-RRB-"},{"id":"T7555","span":{"begin":2861,"end":2862},"obj":"."},{"id":"T7597","span":{"begin":4373,"end":4377},"obj":"NN"},{"id":"T7598","span":{"begin":4366,"end":4372},"obj":"JJ"},{"id":"T7599","span":{"begin":4378,"end":4380},"obj":"IN"},{"id":"T7600","span":{"begin":4381,"end":4385},"obj":"NN"},{"id":"T7601","span":{"begin":4385,"end":4387},"obj":","},{"id":"T7602","span":{"begin":4387,"end":4389},"obj":"PRP"},{"id":"T7603","span":{"begin":4399,"end":4402},"obj":"DT"},{"id":"T7604","span":{"begin":4403,"end":4413},"obj":"NN"},{"id":"T7605","span":{"begin":4414,"end":4416},"obj":"IN"},{"id":"T7606","span":{"begin":4417,"end":4422},"obj":"JJ"},{"id":"T7607","span":{"begin":4427,"end":4434},"obj":"NNS"},{"id":"T7608","span":{"begin":4423,"end":4426},"obj":"NN"},{"id":"T7609","span":{"begin":4435,"end":4437},"obj":"RB"},{"id":"T7610","span":{"begin":4443,"end":4445},"obj":"IN"},{"id":"T7611","span":{"begin":4438,"end":4442},"obj":"RB"},{"id":"T7612","span":{"begin":4446,"end":4451},"obj":"JJ"},{"id":"T7613","span":{"begin":4452,"end":4457},"obj":"NNS"},{"id":"T7614","span":{"begin":4458,"end":4462},"obj":"WDT"},{"id":"T7615","span":{"begin":4463,"end":4471},"obj":"VBP"},{"id":"T7616","span":{"begin":4472,"end":4475},"obj":"DT"},{"id":"T7617","span":{"begin":4481,"end":4486},"obj":"NN"},{"id":"T7618","span":{"begin":4476,"end":4480},"obj":"NN"},{"id":"T7619","span":{"begin":4487,"end":4490},"obj":"CC"},{"id":"T7620","span":{"begin":4491,"end":4500},"obj":"NN"},{"id":"T7621","span":{"begin":4500,"end":4501},"obj":"."},{"id":"T7622","span":{"begin":4501,"end":4619},"obj":"sentence"},{"id":"T7623","span":{"begin":4502,"end":4510},"obj":"JJ"},{"id":"T7624","span":{"begin":4538,"end":4543},"obj":"NN"},{"id":"T7625","span":{"begin":4511,"end":4519},"obj":"JJ"},{"id":"T7626","span":{"begin":4520,"end":4523},"obj":"CC"},{"id":"T7627","span":{"begin":4524,"end":4532},"obj":"JJ"},{"id":"T7628","span":{"begin":4533,"end":4537},"obj":"NN"},{"id":"T7629","span":{"begin":4577,"end":4586},"obj":"VBN"},{"id":"T7630","span":{"begin":4544,"end":4547},"obj":"CC"},{"id":"T7631","span":{"begin":4548,"end":4557},"obj":"JJ"},{"id":"T7632","span":{"begin":4558,"end":4568},"obj":"NNS"},{"id":"T7633","span":{"begin":4569,"end":4573},"obj":"VBD"},{"id":"T7634","span":{"begin":4574,"end":4576},"obj":"RB"},{"id":"T7635","span":{"begin":4576,"end":4577},"obj":"HYPH"},{"id":"T7636","span":{"begin":4587,"end":4589},"obj":"IN"},{"id":"T7637","span":{"begin":4590,"end":4593},"obj":"DT"},{"id":"T7638","span":{"begin":4600,"end":4606},"obj":"NN"},{"id":"T7639","span":{"begin":4594,"end":4596},"obj":"NN"},{"id":"T7640","span":{"begin":4597,"end":4599},"obj":"NN"},{"id":"T7641","span":{"begin":4607,"end":4608},"obj":"-LRB-"},{"id":"T7642","span":{"begin":4615,"end":4617},"obj":"NN"},{"id":"T7643","span":{"begin":4608,"end":4614},"obj":"NN"},{"id":"T7644","span":{"begin":4617,"end":4618},"obj":"-RRB-"},{"id":"T7645","span":{"begin":4618,"end":4619},"obj":"."},{"id":"T7646","span":{"begin":4619,"end":4744},"obj":"sentence"},{"id":"T7647","span":{"begin":4620,"end":4625},"obj":"IN"},{"id":"T7648","span":{"begin":4675,"end":4682},"obj":"VBN"},{"id":"T7649","span":{"begin":4626,"end":4629},"obj":"DT"},{"id":"T7650","span":{"begin":4634,"end":4640},"obj":"NN"},{"id":"T7651","span":{"begin":4630,"end":4633},"obj":"NN"},{"id":"T7652","span":{"begin":4640,"end":4642},"obj":","},{"id":"T7653","span":{"begin":4642,"end":4646},"obj":"NN"},{"id":"T7654","span":{"begin":4646,"end":4648},"obj":","},{"id":"T7655","span":{"begin":4648,"end":4652},"obj":"NN"},{"id":"T7656","span":{"begin":4652,"end":4654},"obj":","},{"id":"T7657","span":{"begin":4654,"end":4659},"obj":"NN"},{"id":"T7658","span":{"begin":4659,"end":4661},"obj":","},{"id":"T7659","span":{"begin":4661,"end":4664},"obj":"CC"},{"id":"T7660","span":{"begin":4665,"end":4669},"obj":"NN"},{"id":"T7661","span":{"begin":4670,"end":4674},"obj":"VBD"},{"id":"T7662","span":{"begin":4683,"end":4692},"obj":"VBG"},{"id":"T7663","span":{"begin":4693,"end":4695},"obj":"NN"},{"id":"T7664","span":{"begin":4696,"end":4700},"obj":"NN"},{"id":"T7665","span":{"begin":4700,"end":4702},"obj":","},{"id":"T7666","span":{"begin":4702,"end":4705},"obj":"CC"},{"id":"T7667","span":{"begin":4706,"end":4711},"obj":"NN"},{"id":"T7668","span":{"begin":4728,"end":4732},"obj":"VBD"},{"id":"T7669","span":{"begin":4711,"end":4713},"obj":","},{"id":"T7670","span":{"begin":4713,"end":4717},"obj":"NN"},{"id":"T7671","span":{"begin":4717,"end":4719},"obj":","},{"id":"T7672","span":{"begin":4719,"end":4722},"obj":"CC"},{"id":"T7673","span":{"begin":4723,"end":4727},"obj":"NN"},{"id":"T7674","span":{"begin":4733,"end":4743},"obj":"JJ"},{"id":"T7675","span":{"begin":4743,"end":4744},"obj":"."},{"id":"T7676","span":{"begin":4744,"end":4934},"obj":"sentence"},{"id":"T7677","span":{"begin":4745,"end":4755},"obj":"JJ"},{"id":"T7678","span":{"begin":4852,"end":4860},"obj":"VBD"},{"id":"T7679","span":{"begin":4756,"end":4760},"obj":"IN"},{"id":"T7680","span":{"begin":4761,"end":4764},"obj":"DT"},{"id":"T7681","span":{"begin":4815,"end":4823},"obj":"NNS"},{"id":"T7682","span":{"begin":4765,"end":4769},"obj":"NN"},{"id":"T7683","span":{"begin":4770,"end":4773},"obj":"CC"},{"id":"T7684","span":{"begin":4774,"end":4782},"obj":"JJ"},{"id":"T7685","span":{"begin":4797,"end":4806},"obj":"NN"},{"id":"T7686","span":{"begin":4783,"end":4787},"obj":"NN"},{"id":"T7687","span":{"begin":4788,"end":4792},"obj":"NN"},{"id":"T7688","span":{"begin":4792,"end":4793},"obj":"HYPH"},{"id":"T7689","span":{"begin":4793,"end":4796},"obj":"NN"},{"id":"T7690","span":{"begin":4807,"end":4808},"obj":"-LRB-"},{"id":"T7691","span":{"begin":4808,"end":4813},"obj":"NN"},{"id":"T7692","span":{"begin":4813,"end":4814},"obj":"-RRB-"},{"id":"T7693","span":{"begin":4823,"end":4825},"obj":","},{"id":"T7694","span":{"begin":4825,"end":4829},"obj":"NN"},{"id":"T7695","span":{"begin":4830,"end":4838},"obj":"NN"},{"id":"T7696","span":{"begin":4839,"end":4851},"obj":"RB"},{"id":"T7697","span":{"begin":4861,"end":4864},"obj":"PDT"},{"id":"T7698","span":{"begin":4881,"end":4888},"obj":"NNS"},{"id":"T7699","span":{"begin":4865,"end":4870},"obj":"DT"},{"id":"T7700","span":{"begin":4871,"end":4880},"obj":"JJ"},{"id":"T7701","span":{"begin":4888,"end":4890},"obj":","},{"id":"T7702","span":{"begin":4890,"end":4893},"obj":"CC"},{"id":"T7703","span":{"begin":4894,"end":4898},"obj":"NN"},{"id":"T7704","span":{"begin":4899,"end":4907},"obj":"NN"},{"id":"T7705","span":{"begin":4908,"end":4911},"obj":"VBD"},{"id":"T7706","span":{"begin":4912,"end":4914},"obj":"DT"},{"id":"T7707","span":{"begin":4915,"end":4921},"obj":"NN"},{"id":"T7708","span":{"begin":4922,"end":4923},"obj":"-LRB-"},{"id":"T7709","span":{"begin":4930,"end":4932},"obj":"NN"},{"id":"T7710","span":{"begin":4923,"end":4929},"obj":"NN"},{"id":"T7711","span":{"begin":4932,"end":4933},"obj":"-RRB-"},{"id":"T7712","span":{"begin":4933,"end":4934},"obj":"."},{"id":"T34466","span":{"begin":3239,"end":3241},"obj":","},{"id":"T34416","span":{"begin":2997,"end":3001},"obj":"NN"},{"id":"T34417","span":{"begin":3002,"end":3010},"obj":"NN"},{"id":"T34418","span":{"begin":3011,"end":3018},"obj":"VBZ"},{"id":"T34419","span":{"begin":3019,"end":3027},"obj":"NN"},{"id":"T34420","span":{"begin":3046,"end":3051},"obj":"NNS"},{"id":"T34421","span":{"begin":3027,"end":3029},"obj":","},{"id":"T34422","span":{"begin":3029,"end":3032},"obj":"NN"},{"id":"T34423","span":{"begin":3032,"end":3034},"obj":","},{"id":"T34424","span":{"begin":3034,"end":3037},"obj":"CC"},{"id":"T34425","span":{"begin":3038,"end":3045},"obj":"JJ"},{"id":"T34426","span":{"begin":3052,"end":3054},"obj":"IN"},{"id":"T34427","span":{"begin":3055,"end":3058},"obj":"DT"},{"id":"T34428","span":{"begin":3065,"end":3071},"obj":"NN"},{"id":"T34429","span":{"begin":3059,"end":3061},"obj":"NN"},{"id":"T34430","span":{"begin":3062,"end":3064},"obj":"NN"},{"id":"T34431","span":{"begin":3071,"end":3338},"obj":"sentence"},{"id":"T34432","span":{"begin":3072,"end":3073},"obj":"-LRB-"},{"id":"T34433","span":{"begin":3073,"end":3074},"obj":"LS"},{"id":"T34434","span":{"begin":3155,"end":3162},"obj":"VBN"},{"id":"T34435","span":{"begin":3074,"end":3075},"obj":"-RRB-"},{"id":"T34436","span":{"begin":3076,"end":3086},"obj":"JJ"},{"id":"T34437","span":{"begin":3095,"end":3103},"obj":"NNS"},{"id":"T34438","span":{"begin":3087,"end":3094},"obj":"JJ"},{"id":"T34439","span":{"begin":3104,"end":3108},"obj":"IN"},{"id":"T34440","span":{"begin":3109,"end":3113},"obj":"NNS"},{"id":"T34441","span":{"begin":3114,"end":3116},"obj":"IN"},{"id":"T34442","span":{"begin":3117,"end":3120},"obj":"DT"},{"id":"T34443","span":{"begin":3131,"end":3135},"obj":"NNS"},{"id":"T34444","span":{"begin":3121,"end":3130},"obj":"VBN"},{"id":"T34445","span":{"begin":3136,"end":3139},"obj":"CC"},{"id":"T34446","span":{"begin":3140,"end":3149},"obj":"NNS"},{"id":"T34447","span":{"begin":3150,"end":3154},"obj":"VBD"},{"id":"T34448","span":{"begin":3163,"end":3166},"obj":"IN"},{"id":"T34449","span":{"begin":3167,"end":3173},"obj":"NNS"},{"id":"T34450","span":{"begin":3174,"end":3175},"obj":"-LRB-"},{"id":"T34451","span":{"begin":3181,"end":3185},"obj":"JJ"},{"id":"T34452","span":{"begin":3175,"end":3179},"obj":"NN"},{"id":"T34453","span":{"begin":3179,"end":3181},"obj":","},{"id":"T34454","span":{"begin":3185,"end":3186},"obj":"-RRB-"},{"id":"T34455","span":{"begin":3187,"end":3190},"obj":"CC"},{"id":"T34456","span":{"begin":3191,"end":3198},"obj":"NNS"},{"id":"T34457","span":{"begin":3199,"end":3203},"obj":"WDT"},{"id":"T34458","span":{"begin":3204,"end":3210},"obj":"VBP"},{"id":"T34459","span":{"begin":3211,"end":3219},"obj":"NN"},{"id":"T34460","span":{"begin":3220,"end":3225},"obj":"NNS"},{"id":"T34461","span":{"begin":3226,"end":3227},"obj":"-LRB-"},{"id":"T34462","span":{"begin":3235,"end":3238},"obj":"JJ"},{"id":"T34463","span":{"begin":3227,"end":3233},"obj":"NN"},{"id":"T34464","span":{"begin":3233,"end":3235},"obj":","},{"id":"T34465","span":{"begin":3238,"end":3239},"obj":"-RRB-"},{"id":"T34467","span":{"begin":3241,"end":3245},"obj":"NNS"},{"id":"T34468","span":{"begin":3246,"end":3249},"obj":"CC"},{"id":"T34469","span":{"begin":3250,"end":3255},"obj":"NNS"},{"id":"T34470","span":{"begin":3256,"end":3257},"obj":"-LRB-"},{"id":"T34471","span":{"begin":3277,"end":3282},"obj":"JJ"},{"id":"T34472","span":{"begin":3257,"end":3260},"obj":"NN"},{"id":"T34473","span":{"begin":3261,"end":3262},"obj":"-LRB-"},{"id":"T34474","span":{"begin":3262,"end":3265},"obj":"NN"},{"id":"T34475","span":{"begin":3266,"end":3274},"obj":"NN"},{"id":"T34476","span":{"begin":3274,"end":3275},"obj":"-RRB-"},{"id":"T34477","span":{"begin":3275,"end":3277},"obj":","},{"id":"T34478","span":{"begin":3282,"end":3283},"obj":"-RRB-"},{"id":"T34479","span":{"begin":3283,"end":3285},"obj":","},{"id":"T34480","span":{"begin":3285,"end":3288},"obj":"CC"},{"id":"T34481","span":{"begin":3289,"end":3292},"obj":"NN"},{"id":"T34482","span":{"begin":3301,"end":3306},"obj":"NNS"},{"id":"T34483","span":{"begin":3293,"end":3300},"obj":"JJ"},{"id":"T34484","span":{"begin":3307,"end":3308},"obj":"-LRB-"},{"id":"T34485","span":{"begin":3315,"end":3320},"obj":"JJ"},{"id":"T34486","span":{"begin":3308,"end":3313},"obj":"NN"},{"id":"T34487","span":{"begin":3313,"end":3315},"obj":","},{"id":"T34488","span":{"begin":3320,"end":3322},"obj":","},{"id":"T34489","span":{"begin":3322,"end":3325},"obj":"CC"},{"id":"T34490","span":{"begin":3326,"end":3331},"obj":"NN"},{"id":"T34491","span":{"begin":3333,"end":3336},"obj":"JJ"},{"id":"T34492","span":{"begin":3331,"end":3333},"obj":","},{"id":"T34493","span":{"begin":3336,"end":3337},"obj":"-RRB-"},{"id":"T34494","span":{"begin":3337,"end":3338},"obj":"."},{"id":"T34495","span":{"begin":3338,"end":3360},"obj":"sentence"},{"id":"T34496","span":{"begin":3339,"end":3344},"obj":"NN"},{"id":"T34497","span":{"begin":3345,"end":3349},"obj":"NNS"},{"id":"T34498","span":{"begin":3350,"end":3353},"obj":"VBP"},{"id":"T34499","span":{"begin":3354,"end":3356},"obj":"CD"},{"id":"T34500","span":{"begin":3357,"end":3359},"obj":"NN"},{"id":"T34501","span":{"begin":3359,"end":3360},"obj":"."},{"id":"T34502","span":{"begin":3360,"end":3406},"obj":"sentence"},{"id":"T34503","span":{"begin":3361,"end":3362},"obj":"-LRB-"},{"id":"T34504","span":{"begin":3362,"end":3363},"obj":"LS"},{"id":"T34505","span":{"begin":3365,"end":3379},"obj":"NN"},{"id":"T34506","span":{"begin":3363,"end":3364},"obj":"-RRB-"},{"id":"T34507","span":{"begin":3380,"end":3382},"obj":"IN"},{"id":"T34508","span":{"begin":3383,"end":3389},"obj":"NN"},{"id":"T34509","span":{"begin":3400,"end":3405},"obj":"NNS"},{"id":"T34510","span":{"begin":3389,"end":3390},"obj":"SYM"},{"id":"T34511","span":{"begin":3391,"end":3399},"obj":"NN"},{"id":"T34512","span":{"begin":3405,"end":3406},"obj":"."},{"id":"T34513","span":{"begin":3406,"end":3461},"obj":"sentence"},{"id":"T34514","span":{"begin":3407,"end":3408},"obj":"-LRB-"},{"id":"T34515","span":{"begin":3408,"end":3409},"obj":"LS"},{"id":"T34516","span":{"begin":3411,"end":3425},"obj":"NN"},{"id":"T34517","span":{"begin":3409,"end":3410},"obj":"-RRB-"},{"id":"T34518","span":{"begin":3426,"end":3428},"obj":"IN"},{"id":"T34519","span":{"begin":3429,"end":3434},"obj":"NN"},{"id":"T34520","span":{"begin":3455,"end":3460},"obj":"NNS"},{"id":"T34521","span":{"begin":3434,"end":3435},"obj":"SYM"},{"id":"T34522","span":{"begin":3436,"end":3439},"obj":"CC"},{"id":"T34523","span":{"begin":3440,"end":3445},"obj":"NN"},{"id":"T34524","span":{"begin":3445,"end":3446},"obj":"SYM"},{"id":"T34525","span":{"begin":3447,"end":3454},"obj":"JJ"},{"id":"T34526","span":{"begin":3460,"end":3461},"obj":"."},{"id":"T34527","span":{"begin":3461,"end":3524},"obj":"sentence"},{"id":"T34528","span":{"begin":3462,"end":3463},"obj":"-LRB-"},{"id":"T34529","span":{"begin":3463,"end":3464},"obj":"LS"},{"id":"T34530","span":{"begin":3466,"end":3475},"obj":"NN"},{"id":"T34531","span":{"begin":3464,"end":3465},"obj":"-RRB-"},{"id":"T34532","span":{"begin":3476,"end":3478},"obj":"IN"},{"id":"T34533","span":{"begin":3479,"end":3482},"obj":"DT"},{"id":"T34534","span":{"begin":3483,"end":3486},"obj":"NN"},{"id":"T34535","span":{"begin":3486,"end":3488},"obj":","},{"id":"T34536","span":{"begin":3488,"end":3493},"obj":"WDT"},{"id":"T34537","span":{"begin":3494,"end":3504},"obj":"VBZ"},{"id":"T34538","span":{"begin":3505,"end":3508},"obj":"DT"},{"id":"T34539","span":{"begin":3509,"end":3515},"obj":"NN"},{"id":"T34540","span":{"begin":3516,"end":3518},"obj":"IN"},{"id":"T34541","span":{"begin":3519,"end":3523},"obj":"NNS"},{"id":"T34542","span":{"begin":3523,"end":3524},"obj":"."},{"id":"T34543","span":{"begin":3524,"end":3785},"obj":"sentence"},{"id":"T34544","span":{"begin":3525,"end":3530},"obj":"NN"},{"id":"T34545","span":{"begin":3531,"end":3535},"obj":"NNS"},{"id":"T34546","span":{"begin":3536,"end":3545},"obj":"VBP"},{"id":"T34547","span":{"begin":3546,"end":3548},"obj":"NN"},{"id":"T34548","span":{"begin":3549,"end":3551},"obj":"IN"},{"id":"T34549","span":{"begin":3552,"end":3564},"obj":"NNS"},{"id":"T34550","span":{"begin":3565,"end":3569},"obj":"IN"},{"id":"T34551","span":{"begin":3570,"end":3575},"obj":"CD"},{"id":"T34552","span":{"begin":3576,"end":3583},"obj":"NNS"},{"id":"T34553","span":{"begin":3583,"end":3585},"obj":","},{"id":"T34554","span":{"begin":3585,"end":3588},"obj":"CC"},{"id":"T34555","span":{"begin":3589,"end":3598},"obj":"NNS"},{"id":"T34556","span":{"begin":3599,"end":3607},"obj":"VBP"},{"id":"T34557","span":{"begin":3608,"end":3609},"obj":"DT"},{"id":"T34558","span":{"begin":3622,"end":3632},"obj":"NN"},{"id":"T34559","span":{"begin":3610,"end":3621},"obj":"JJ"},{"id":"T34560","span":{"begin":3633,"end":3640},"obj":"IN"},{"id":"T34561","span":{"begin":3641,"end":3648},"obj":"NNS"},{"id":"T34562","span":{"begin":3649,"end":3651},"obj":"IN"},{"id":"T34563","span":{"begin":3652,"end":3654},"obj":"NN"},{"id":"T34564","span":{"begin":3655,"end":3658},"obj":"CC"},{"id":"T34565","span":{"begin":3659,"end":3662},"obj":"DT"},{"id":"T34566","span":{"begin":3663,"end":3672},"obj":"VBN"},{"id":"T34567","span":{"begin":3673,"end":3682},"obj":"NNS"},{"id":"T34568","span":{"begin":3682,"end":3684},"obj":","},{"id":"T34569","span":{"begin":3684,"end":3690},"obj":"IN"},{"id":"T34570","span":{"begin":3691,"end":3700},"obj":"VBN"},{"id":"T34571","span":{"begin":3701,"end":3710},"obj":"RB"},{"id":"T34572","span":{"begin":3711,"end":3713},"obj":"IN"},{"id":"T34573","span":{"begin":3714,"end":3724},"obj":"VBG"},{"id":"T34574","span":{"begin":3725,"end":3730},"obj":"NNS"},{"id":"T34575","span":{"begin":3731,"end":3732},"obj":"-LRB-"},{"id":"T34576","span":{"begin":3779,"end":3783},"obj":"NN"},{"id":"T34577","span":{"begin":3732,"end":3733},"obj":"SYM"},{"id":"T34578","span":{"begin":3739,"end":3743},"obj":"CD"},{"id":"T34579","span":{"begin":3733,"end":3735},"obj":","},{"id":"T34580","span":{"begin":3735,"end":3736},"obj":"NN"},{"id":"T34581","span":{"begin":3737,"end":3738},"obj":"SYM"},{"id":"T34582","span":{"begin":3743,"end":3744},"obj":":"},{"id":"T34583","span":{"begin":3745,"end":3747},"obj":"SYM"},{"id":"T34584","span":{"begin":3753,"end":3757},"obj":"CD"},{"id":"T34585","span":{"begin":3747,"end":3748},"obj":":"},{"id":"T34586","span":{"begin":3749,"end":3750},"obj":"NN"},{"id":"T34587","span":{"begin":3751,"end":3752},"obj":"SYM"},{"id":"T34588","span":{"begin":3757,"end":3758},"obj":":"},{"id":"T34589","span":{"begin":3759,"end":3764},"obj":"NN"},{"id":"T34590","span":{"begin":3765,"end":3768},"obj":"CC"},{"id":"T34591","span":{"begin":3769,"end":3774},"obj":"NNP"},{"id":"T34592","span":{"begin":3775,"end":3778},"obj":"NN"},{"id":"T34593","span":{"begin":3783,"end":3784},"obj":"-RRB-"},{"id":"T34594","span":{"begin":3784,"end":3785},"obj":"."},{"id":"T34595","span":{"begin":3785,"end":4007},"obj":"sentence"},{"id":"T34596","span":{"begin":3786,"end":3787},"obj":"-LRB-"},{"id":"T34597","span":{"begin":3787,"end":3788},"obj":"LS"},{"id":"T34598","span":{"begin":3806,"end":3814},"obj":"VBN"},{"id":"T34599","span":{"begin":3789,"end":3792},"obj":"CC"},{"id":"T34600","span":{"begin":3793,"end":3794},"obj":"LS"},{"id":"T34601","span":{"begin":3794,"end":3795},"obj":"-RRB-"},{"id":"T34602","span":{"begin":3796,"end":3800},"obj":"NNS"},{"id":"T34603","span":{"begin":3801,"end":3805},"obj":"VBD"},{"id":"T34604","span":{"begin":3815,"end":3819},"obj":"IN"},{"id":"T34605","span":{"begin":3820,"end":3823},"obj":"DT"},{"id":"T34606","span":{"begin":3834,"end":3843},"obj":"NNS"},{"id":"T34607","span":{"begin":3824,"end":3833},"obj":"VBN"},{"id":"T34608","span":{"begin":3844,"end":3849},"obj":"IN"},{"id":"T34609","span":{"begin":3850,"end":3854},"obj":"NN"},{"id":"T34610","span":{"begin":3855,"end":3862},"obj":"VBN"},{"id":"T34611","span":{"begin":3854,"end":3855},"obj":"HYPH"},{"id":"T34612","span":{"begin":3874,"end":3884},"obj":"NNS"},{"id":"T34613","span":{"begin":3863,"end":3864},"obj":"-LRB-"},{"id":"T34614","span":{"begin":3864,"end":3872},"obj":"JJ"},{"id":"T34615","span":{"begin":3872,"end":3873},"obj":"-RRB-"},{"id":"T34616","span":{"begin":3884,"end":3886},"obj":","},{"id":"T34617","span":{"begin":3886,"end":3889},"obj":"CC"},{"id":"T34618","span":{"begin":3890,"end":3891},"obj":"-LRB-"},{"id":"T34619","span":{"begin":3891,"end":3892},"obj":"NN"},{"id":"T34620","span":{"begin":3904,"end":3910},"obj":"NN"},{"id":"T34621","span":{"begin":3892,"end":3893},"obj":"-RRB-"},{"id":"T34622","span":{"begin":3894,"end":3903},"obj":"NN"},{"id":"T34623","span":{"begin":3996,"end":4006},"obj":"VBN"},{"id":"T34624","span":{"begin":3911,"end":3914},"obj":"CC"},{"id":"T34625","span":{"begin":3915,"end":3916},"obj":"-LRB-"},{"id":"T34626","span":{"begin":3916,"end":3917},"obj":"NN"},{"id":"T34627","span":{"begin":3926,"end":3936},"obj":"NNS"},{"id":"T34628","span":{"begin":3917,"end":3918},"obj":"-RRB-"},{"id":"T34629","span":{"begin":3919,"end":3920},"obj":"NN"},{"id":"T34630","span":{"begin":3921,"end":3925},"obj":"NN"},{"id":"T34631","span":{"begin":3920,"end":3921},"obj":"HYPH"},{"id":"T34632","span":{"begin":3937,"end":3939},"obj":"IN"},{"id":"T34633","span":{"begin":3940,"end":3941},"obj":"DT"},{"id":"T34634","span":{"begin":3942,"end":3950},"obj":"NN"},{"id":"T34635","span":{"begin":3951,"end":3953},"obj":"IN"},{"id":"T34636","span":{"begin":3954,"end":3957},"obj":"DT"},{"id":"T34637","span":{"begin":3958,"end":3967},"obj":"NN"},{"id":"T34638","span":{"begin":3968,"end":3970},"obj":"IN"},{"id":"T34639","span":{"begin":3971,"end":3974},"obj":"DT"},{"id":"T34640","span":{"begin":3981,"end":3990},"obj":"NN"},{"id":"T34641","span":{"begin":3975,"end":3980},"obj":"NN"},{"id":"T34642","span":{"begin":3991,"end":3995},"obj":"VBD"},{"id":"T34643","span":{"begin":4006,"end":4007},"obj":"."},{"id":"T34644","span":{"begin":4007,"end":4307},"obj":"sentence"},{"id":"T34645","span":{"begin":4008,"end":4009},"obj":"-LRB-"},{"id":"T34646","span":{"begin":4020,"end":4031},"obj":"VBZ"},{"id":"T34647","span":{"begin":4009,"end":4010},"obj":"NN"},{"id":"T34648","span":{"begin":4010,"end":4011},"obj":"-RRB-"},{"id":"T34649","span":{"begin":4012,"end":4019},"obj":"RB"},{"id":"T34650","span":{"begin":4032,"end":4036},"obj":"IN"},{"id":"T34651","span":{"begin":4158,"end":4161},"obj":"VBD"},{"id":"T34652","span":{"begin":4037,"end":4040},"obj":"DT"},{"id":"T34653","span":{"begin":4050,"end":4059},"obj":"NN"},{"id":"T34654","span":{"begin":4041,"end":4049},"obj":"JJ"},{"id":"T34655","span":{"begin":4060,"end":4062},"obj":"IN"},{"id":"T34656","span":{"begin":4063,"end":4066},"obj":"DT"},{"id":"T34657","span":{"begin":4067,"end":4076},"obj":"NNS"},{"id":"T34658","span":{"begin":4077,"end":4079},"obj":"IN"},{"id":"T34659","span":{"begin":4080,"end":4083},"obj":"DT"},{"id":"T34660","span":{"begin":4084,"end":4098},"obj":"NNS"},{"id":"T34661","span":{"begin":4099,"end":4100},"obj":"-LRB-"},{"id":"T34662","span":{"begin":4100,"end":4109},"obj":"VBN"},{"id":"T34663","span":{"begin":4110,"end":4112},"obj":"IN"},{"id":"T34664","span":{"begin":4113,"end":4116},"obj":"DT"},{"id":"T34665","span":{"begin":4134,"end":4143},"obj":"NN"},{"id":"T34666","span":{"begin":4117,"end":4126},"obj":"VBN"},{"id":"T34667","span":{"begin":4127,"end":4128},"obj":"NN"},{"id":"T34668","span":{"begin":4129,"end":4133},"obj":"NN"},{"id":"T34669","span":{"begin":4128,"end":4129},"obj":"HYPH"},{"id":"T34670","span":{"begin":4143,"end":4145},"obj":","},{"id":"T34671","span":{"begin":4151,"end":4156},"obj":"NN"},{"id":"T34672","span":{"begin":4145,"end":4150},"obj":"JJ"},{"id":"T34673","span":{"begin":4156,"end":4157},"obj":"-RRB-"},{"id":"T34674","span":{"begin":4162,"end":4165},"obj":"RB"},{"id":"T34675","span":{"begin":4166,"end":4179},"obj":"RB"},{"id":"T34676","span":{"begin":4180,"end":4189},"obj":"JJ"},{"id":"T34677","span":{"begin":4190,"end":4194},"obj":"IN"},{"id":"T34678","span":{"begin":4195,"end":4200},"obj":"PRP$"},{"id":"T34679","span":{"begin":4201,"end":4207},"obj":"NN"},{"id":"T34680","span":{"begin":4208,"end":4210},"obj":"IN"},{"id":"T34681","span":{"begin":4211,"end":4214},"obj":"DT"},{"id":"T34682","span":{"begin":4222,"end":4230},"obj":"NN"},{"id":"T34683","span":{"begin":4215,"end":4216},"obj":"NN"},{"id":"T34684","span":{"begin":4217,"end":4221},"obj":"NN"},{"id":"T34685","span":{"begin":4216,"end":4217},"obj":"HYPH"},{"id":"T34686","span":{"begin":4231,"end":4232},"obj":"-LRB-"},{"id":"T34687","span":{"begin":4232,"end":4241},"obj":"VBN"},{"id":"T34688","span":{"begin":4242,"end":4244},"obj":"IN"},{"id":"T34689","span":{"begin":4245,"end":4248},"obj":"DT"},{"id":"T34690","span":{"begin":4249,"end":4257},"obj":"NNS"},{"id":"T34691","span":{"begin":4257,"end":4259},"obj":","},{"id":"T34692","span":{"begin":4264,"end":4269},"obj":"NN"},{"id":"T34693","span":{"begin":4259,"end":4263},"obj":"JJ"},{"id":"T34694","span":{"begin":4269,"end":4270},"obj":"-RRB-"},{"id":"T34695","span":{"begin":4271,"end":4273},"obj":"IN"},{"id":"T34696","span":{"begin":4274,"end":4277},"obj":"DT"},{"id":"T34697","span":{"begin":4283,"end":4292},"obj":"NN"},{"id":"T34698","span":{"begin":4278,"end":4282},"obj":"JJ"},{"id":"T34699","span":{"begin":4293,"end":4295},"obj":"IN"},{"id":"T34700","span":{"begin":4296,"end":4298},"obj":"CD"},{"id":"T34701","span":{"begin":4302,"end":4303},"obj":"NN"},{"id":"T34702","span":{"begin":4299,"end":4301},"obj":"NN"},{"id":"T34703","span":{"begin":4301,"end":4302},"obj":"SYM"},{"id":"T34704","span":{"begin":4303,"end":4304},"obj":"SYM"},{"id":"T34705","span":{"begin":4304,"end":4306},"obj":"NN"},{"id":"T34706","span":{"begin":4306,"end":4307},"obj":"."},{"id":"T7556","span":{"begin":2862,"end":2986},"obj":"sentence"},{"id":"T7557","span":{"begin":2863,"end":2871},"obj":"VBG"},{"id":"T7558","span":{"begin":2900,"end":2907},"obj":"VBD"},{"id":"T7559","span":{"begin":2872,"end":2876},"obj":"NN"},{"id":"T7560","span":{"begin":2876,"end":2878},"obj":","},{"id":"T7561","span":{"begin":2878,"end":2881},"obj":"CC"},{"id":"T7562","span":{"begin":2882,"end":2885},"obj":"RB"},{"id":"T7563","span":{"begin":2886,"end":2890},"obj":"NN"},{"id":"T7564","span":{"begin":2891,"end":2893},"obj":"CC"},{"id":"T7565","span":{"begin":2894,"end":2898},"obj":"NN"},{"id":"T7566","span":{"begin":2898,"end":2900},"obj":","},{"id":"T7567","span":{"begin":2908,"end":2912},"obj":"DT"},{"id":"T7568","span":{"begin":2926,"end":2931},"obj":"NN"},{"id":"T7569","span":{"begin":2913,"end":2920},"obj":"JJ"},{"id":"T7570","span":{"begin":2921,"end":2925},"obj":"NN"},{"id":"T7571","span":{"begin":2932,"end":2934},"obj":"IN"},{"id":"T7572","span":{"begin":2935,"end":2936},"obj":"DT"},{"id":"T7573","span":{"begin":2952,"end":2959},"obj":"NN"},{"id":"T7574","span":{"begin":2937,"end":2941},"obj":"NN"},{"id":"T7575","span":{"begin":2942,"end":2951},"obj":"JJ"},{"id":"T7576","span":{"begin":2941,"end":2942},"obj":"HYPH"},{"id":"T7577","span":{"begin":2960,"end":2961},"obj":"-LRB-"},{"id":"T7578","span":{"begin":2969,"end":2971},"obj":"NN"},{"id":"T7579","span":{"begin":2961,"end":2968},"obj":"NNS"},{"id":"T7580","span":{"begin":2971,"end":2973},"obj":","},{"id":"T7581","span":{"begin":2973,"end":2975},"obj":"NN"},{"id":"T7582","span":{"begin":2975,"end":2977},"obj":","},{"id":"T7583","span":{"begin":2977,"end":2980},"obj":"CC"},{"id":"T7584","span":{"begin":2981,"end":2984},"obj":"NN"},{"id":"T7585","span":{"begin":2984,"end":2985},"obj":"-RRB-"},{"id":"T7586","span":{"begin":2985,"end":2986},"obj":"."},{"id":"T7587","span":{"begin":2986,"end":4501},"obj":"sentence"},{"id":"T7588","span":{"begin":4308,"end":4310},"obj":"TO"},{"id":"T7589","span":{"begin":4311,"end":4322},"obj":"VB"},{"id":"T7590","span":{"begin":4390,"end":4398},"obj":"VBD"},{"id":"T7591","span":{"begin":4323,"end":4326},"obj":"DT"},{"id":"T7592","span":{"begin":4337,"end":4346},"obj":"NN"},{"id":"T7593","span":{"begin":4327,"end":4336},"obj":"JJ"},{"id":"T7594","span":{"begin":4347,"end":4351},"obj":"WDT"},{"id":"T7595","span":{"begin":4352,"end":4361},"obj":"VBZ"},{"id":"T7596","span":{"begin":4362,"end":4365},"obj":"DT"}],"relations":[{"id":"R1519","pred":"nsubj","subj":"T6888","obj":"T6889"},{"id":"R1520","pred":"dobj","subj":"T6890","obj":"T6889"},{"id":"R1521","pred":"cc","subj":"T6891","obj":"T6890"},{"id":"R1522","pred":"conj","subj":"T6892","obj":"T6890"},{"id":"R1523","pred":"prep","subj":"T6893","obj":"T6889"},{"id":"R1524","pred":"pobj","subj":"T6894","obj":"T6893"},{"id":"R1525","pred":"nsubj","subj":"T6896","obj":"T6897"},{"id":"R1526","pred":"det","subj":"T6898","obj":"T6899"},{"id":"R1527","pred":"dobj","subj":"T6899","obj":"T6897"},{"id":"R1528","pred":"compound","subj":"T6900","obj":"T6901"},{"id":"R1529","pred":"compound","subj":"T6901","obj":"T6899"},{"id":"R1530","pred":"punct","subj":"T6902","obj":"T6901"},{"id":"R1531","pred":"aux","subj":"T6903","obj":"T6904"},{"id":"R1532","pred":"advcl","subj":"T6904","obj":"T6897"},{"id":"R1533","pred":"amod","subj":"T6905","obj":"T6906"},{"id":"R1534","pred":"dobj","subj":"T6906","obj":"T6904"},{"id":"R1535","pred":"compound","subj":"T6907","obj":"T6906"},{"id":"R1536","pred":"nummod","subj":"T6908","obj":"T6906"},{"id":"R1537","pred":"prep","subj":"T6909","obj":"T6904"},{"id":"R1538","pred":"amod","subj":"T6910","obj":"T6911"},{"id":"R1539","pred":"pobj","subj":"T6911","obj":"T6909"},{"id":"R1540","pred":"punct","subj":"T6912","obj":"T6911"},{"id":"R1541","pred":"appos","subj":"T6913","obj":"T6911"},{"id":"R1542","pred":"punct","subj":"T6914","obj":"T6911"},{"id":"R1543","pred":"nummod","subj":"T6915","obj":"T6911"},{"id":"R1544","pred":"prep","subj":"T6916","obj":"T6904"},{"id":"R1545","pred":"amod","subj":"T6917","obj":"T6918"},{"id":"R1546","pred":"pobj","subj":"T6918","obj":"T6916"},{"id":"R1547","pred":"punct","subj":"T6919","obj":"T6920"},{"id":"R1548","pred":"parataxis","subj":"T6920","obj":"T6897"},{"id":"R1549","pred":"punct","subj":"T6921","obj":"T6920"},{"id":"R1550","pred":"punct","subj":"T6922","obj":"T6897"},{"id":"R1551","pred":"nmod","subj":"T6924","obj":"T6925"},{"id":"R1552","pred":"nmod","subj":"T6925","obj":"T6927"},{"id":"R1553","pred":"punct","subj":"T6926","obj":"T6925"},{"id":"R1554","pred":"nsubjpass","subj":"T6927","obj":"T6932"},{"id":"R1555","pred":"punct","subj":"T6928","obj":"T6925"},{"id":"R1556","pred":"compound","subj":"T6929","obj":"T6930"},{"id":"R1557","pred":"appos","subj":"T6930","obj":"T6925"},{"id":"R1558","pred":"punct","subj":"T6931","obj":"T6930"},{"id":"R1559","pred":"auxpass","subj":"T6933","obj":"T6932"},{"id":"R1560","pred":"prep","subj":"T6934","obj":"T6932"},{"id":"R1561","pred":"pobj","subj":"T6935","obj":"T6934"},{"id":"R1562","pred":"acl","subj":"T6936","obj":"T6935"},{"id":"R1563","pred":"dobj","subj":"T6937","obj":"T6936"},{"id":"R1564","pred":"cc","subj":"T6938","obj":"T6937"},{"id":"R1565","pred":"conj","subj":"T6939","obj":"T6937"},{"id":"R1566","pred":"prep","subj":"T6940","obj":"T6936"},{"id":"R1567","pred":"det","subj":"T6941","obj":"T6942"},{"id":"R1568","pred":"pobj","subj":"T6942","obj":"T6940"},{"id":"R1569","pred":"compound","subj":"T6943","obj":"T6942"},{"id":"R1570","pred":"punct","subj":"T6944","obj":"T6935"},{"id":"R1571","pred":"cc","subj":"T6945","obj":"T6935"},{"id":"R1572","pred":"det","subj":"T6946","obj":"T6947"},{"id":"R1573","pred":"conj","subj":"T6947","obj":"T6935"},{"id":"R1574","pred":"acl","subj":"T6948","obj":"T6947"},{"id":"R1575","pred":"det","subj":"T6949","obj":"T6950"},{"id":"R1576","pred":"dobj","subj":"T6950","obj":"T6948"},{"id":"R1577","pred":"amod","subj":"T6951","obj":"T6950"},{"id":"R1578","pred":"compound","subj":"T6952","obj":"T6950"},{"id":"R1579","pred":"punct","subj":"T6953","obj":"T6954"},{"id":"R1580","pred":"parataxis","subj":"T6954","obj":"T6932"},{"id":"R1581","pred":"punct","subj":"T6955","obj":"T6954"},{"id":"R1582","pred":"punct","subj":"T6956","obj":"T6932"},{"id":"R1583","pred":"nmod","subj":"T6958","obj":"T6959"},{"id":"R1584","pred":"nmod","subj":"T6959","obj":"T6961"},{"id":"R1585","pred":"punct","subj":"T6960","obj":"T6959"},{"id":"R1586","pred":"nsubjpass","subj":"T6961","obj":"T6980"},{"id":"R1587","pred":"punct","subj":"T6962","obj":"T6959"},{"id":"R1588","pred":"appos","subj":"T6963","obj":"T6959"},{"id":"R1589","pred":"punct","subj":"T6964","obj":"T6963"},{"id":"R1590","pred":"punct","subj":"T6965","obj":"T6963"},{"id":"R1591","pred":"punct","subj":"T6966","obj":"T6963"},{"id":"R1592","pred":"cc","subj":"T6967","obj":"T6959"},{"id":"R1593","pred":"compound","subj":"T6968","obj":"T6969"},{"id":"R1594","pred":"conj","subj":"T6969","obj":"T6959"},{"id":"R1595","pred":"punct","subj":"T6970","obj":"T6969"},{"id":"R1596","pred":"punct","subj":"T6971","obj":"T6969"},{"id":"R1597","pred":"appos","subj":"T6972","obj":"T6969"},{"id":"R1598","pred":"punct","subj":"T6973","obj":"T6972"},{"id":"R1599","pred":"punct","subj":"T6974","obj":"T6972"},{"id":"R1600","pred":"punct","subj":"T6975","obj":"T6972"},{"id":"R1601","pred":"punct","subj":"T6976","obj":"T6959"},{"id":"R1602","pred":"compound","subj":"T6977","obj":"T6978"},{"id":"R1603","pred":"appos","subj":"T6978","obj":"T6959"},{"id":"R1604","pred":"punct","subj":"T6979","obj":"T6978"},{"id":"R1605","pred":"auxpass","subj":"T6981","obj":"T6980"},{"id":"R1606","pred":"aux","subj":"T6982","obj":"T6983"},{"id":"R1607","pred":"advcl","subj":"T6983","obj":"T6980"},{"id":"R1608","pred":"nmod","subj":"T6984","obj":"T6985"},{"id":"R1609","pred":"nmod","subj":"T6985","obj":"T6987"},{"id":"R1610","pred":"punct","subj":"T6986","obj":"T6985"},{"id":"R1611","pred":"dobj","subj":"T6987","obj":"T6983"},{"id":"R1612","pred":"punct","subj":"T6988","obj":"T6985"},{"id":"R1613","pred":"appos","subj":"T6989","obj":"T6985"},{"id":"R1614","pred":"punct","subj":"T6990","obj":"T6989"},{"id":"R1615","pred":"punct","subj":"T6991","obj":"T6989"},{"id":"R1616","pred":"punct","subj":"T6992","obj":"T6989"},{"id":"R1617","pred":"punct","subj":"T6993","obj":"T6985"},{"id":"R1618","pred":"compound","subj":"T6994","obj":"T6995"},{"id":"R1619","pred":"appos","subj":"T6995","obj":"T6985"},{"id":"R1620","pred":"punct","subj":"T6996","obj":"T6995"},{"id":"R1621","pred":"prep","subj":"T6997","obj":"T6983"},{"id":"R1622","pred":"det","subj":"T6998","obj":"T6999"},{"id":"R1623","pred":"pobj","subj":"T6999","obj":"T6997"},{"id":"R1624","pred":"prep","subj":"T7000","obj":"T6999"},{"id":"R1625","pred":"nummod","subj":"T7001","obj":"T7002"},{"id":"R1626","pred":"pobj","subj":"T7002","obj":"T7000"},{"id":"R1627","pred":"punct","subj":"T7003","obj":"T7002"},{"id":"R1628","pred":"cc","subj":"T7004","obj":"T6980"},{"id":"R1629","pred":"compound","subj":"T7005","obj":"T7006"},{"id":"R1630","pred":"conj","subj":"T7006","obj":"T6980"},{"id":"R1631","pred":"prep","subj":"T7007","obj":"T7006"},{"id":"R1632","pred":"det","subj":"T7008","obj":"T7009"},{"id":"R1633","pred":"pobj","subj":"T7009","obj":"T7007"},{"id":"R1634","pred":"cc","subj":"T7010","obj":"T7009"},{"id":"R1635","pred":"nmod","subj":"T7011","obj":"T7012"},{"id":"R1636","pred":"conj","subj":"T7012","obj":"T7009"},{"id":"R1637","pred":"punct","subj":"T7013","obj":"T7014"},{"id":"R1638","pred":"parataxis","subj":"T7014","obj":"T7011"},{"id":"R1639","pred":"punct","subj":"T7015","obj":"T7016"},{"id":"R1640","pred":"prep","subj":"T7016","obj":"T7014"},{"id":"R1641","pred":"punct","subj":"T7017","obj":"T7014"},{"id":"R1642","pred":"punct","subj":"T7018","obj":"T7006"},{"id":"R1643","pred":"prep","subj":"T7020","obj":"T7021"},{"id":"R1644","pred":"pobj","subj":"T7022","obj":"T7020"},{"id":"R1645","pred":"nsubj","subj":"T7023","obj":"T7021"},{"id":"R1646","pred":"aux","subj":"T7024","obj":"T7021"},{"id":"R1647","pred":"prep","subj":"T7025","obj":"T7021"},{"id":"R1648","pred":"det","subj":"T7026","obj":"T7027"},{"id":"R1649","pred":"pobj","subj":"T7027","obj":"T7025"},{"id":"R1650","pred":"nmod","subj":"T7028","obj":"T7029"},{"id":"R1651","pred":"nmod","subj":"T7029","obj":"T7027"},{"id":"R1652","pred":"punct","subj":"T7030","obj":"T7029"},{"id":"R1653","pred":"punct","subj":"T7031","obj":"T7029"},{"id":"R1654","pred":"appos","subj":"T7032","obj":"T7029"},{"id":"R1655","pred":"punct","subj":"T7033","obj":"T7032"},{"id":"R1656","pred":"punct","subj":"T7034","obj":"T7032"},{"id":"R1657","pred":"punct","subj":"T7035","obj":"T7032"},{"id":"R1658","pred":"punct","subj":"T7036","obj":"T7029"},{"id":"R1659","pred":"compound","subj":"T7037","obj":"T7038"},{"id":"R1660","pred":"appos","subj":"T7038","obj":"T7029"},{"id":"R1661","pred":"punct","subj":"T7039","obj":"T7038"},{"id":"R1662","pred":"amod","subj":"T7040","obj":"T7027"},{"id":"R1663","pred":"prep","subj":"T7041","obj":"T7021"},{"id":"R1664","pred":"det","subj":"T7042","obj":"T7043"},{"id":"R1665","pred":"pobj","subj":"T7043","obj":"T7041"},{"id":"R1666","pred":"nmod","subj":"T7044","obj":"T7045"},{"id":"R1667","pred":"nmod","subj":"T7045","obj":"T7043"},{"id":"R1668","pred":"punct","subj":"T7046","obj":"T7045"},{"id":"R1669","pred":"amod","subj":"T7047","obj":"T7048"},{"id":"R1670","pred":"appos","subj":"T7048","obj":"T7045"},{"id":"R1671","pred":"punct","subj":"T7049","obj":"T7048"},{"id":"R1672","pred":"appos","subj":"T7050","obj":"T7048"},{"id":"R1673","pred":"punct","subj":"T7051","obj":"T7043"},{"id":"R1674","pred":"punct","subj":"T7052","obj":"T7021"},{"id":"R1675","pred":"amod","subj":"T7054","obj":"T7055"},{"id":"R1676","pred":"nsubjpass","subj":"T7055","obj":"T7056"},{"id":"R1677","pred":"auxpass","subj":"T7057","obj":"T7056"},{"id":"R1678","pred":"prep","subj":"T7058","obj":"T7056"},{"id":"R1679","pred":"det","subj":"T7059","obj":"T7060"},{"id":"R1680","pred":"pobj","subj":"T7060","obj":"T7058"},{"id":"R1681","pred":"prep","subj":"T7061","obj":"T7060"},{"id":"R1682","pred":"pobj","subj":"T7062","obj":"T7061"},{"id":"R1683","pred":"cc","subj":"T7063","obj":"T7062"},{"id":"R1684","pred":"conj","subj":"T7064","obj":"T7062"},{"id":"R1685","pred":"punct","subj":"T7065","obj":"T7056"},{"id":"R1686","pred":"npadvmod","subj":"T7067","obj":"T7068"},{"id":"R1687","pred":"amod","subj":"T7068","obj":"T7070"},{"id":"R1688","pred":"punct","subj":"T7069","obj":"T7068"},{"id":"R1689","pred":"nsubjpass","subj":"T7070","obj":"T7071"},{"id":"R1690","pred":"prep","subj":"T7072","obj":"T7070"},{"id":"R1691","pred":"nmod","subj":"T7073","obj":"T7074"},{"id":"R1692","pred":"pobj","subj":"T7074","obj":"T7072"},{"id":"R1693","pred":"cc","subj":"T7075","obj":"T7073"},{"id":"R1694","pred":"conj","subj":"T7076","obj":"T7073"},{"id":"R1695","pred":"prep","subj":"T7077","obj":"T7070"},{"id":"R1696","pred":"det","subj":"T7078","obj":"T7079"},{"id":"R1697","pred":"pobj","subj":"T7079","obj":"T7077"},{"id":"R1698","pred":"auxpass","subj":"T7080","obj":"T7071"},{"id":"R1699","pred":"prep","subj":"T7081","obj":"T7071"},{"id":"R1700","pred":"pobj","subj":"T7082","obj":"T7081"},{"id":"R1701","pred":"mark","subj":"T7083","obj":"T7084"},{"id":"R1702","pred":"advcl","subj":"T7084","obj":"T7071"},{"id":"R1703","pred":"advmod","subj":"T7085","obj":"T7084"},{"id":"R1704","pred":"punct","subj":"T7086","obj":"T7087"},{"id":"R1705","pred":"parataxis","subj":"T7087","obj":"T7071"},{"id":"R1706","pred":"nummod","subj":"T7088","obj":"T7087"},{"id":"R1707","pred":"punct","subj":"T7089","obj":"T7087"},{"id":"R1708","pred":"punct","subj":"T7090","obj":"T7087"},{"id":"R1709","pred":"punct","subj":"T7091","obj":"T7071"},{"id":"R1710","pred":"aux","subj":"T7093","obj":"T7094"},{"id":"R1711","pred":"advcl","subj":"T7094","obj":"T7095"},{"id":"R1712","pred":"amod","subj":"T7096","obj":"T7097"},{"id":"R1713","pred":"dobj","subj":"T7097","obj":"T7094"},{"id":"R1714","pred":"compound","subj":"T7098","obj":"T7097"},{"id":"R1715","pred":"punct","subj":"T7099","obj":"T7095"},{"id":"R1716","pred":"nsubjpass","subj":"T7100","obj":"T7095"},{"id":"R1717","pred":"auxpass","subj":"T7101","obj":"T7095"},{"id":"R1718","pred":"dep","subj":"T7102","obj":"T7095"},{"id":"R1719","pred":"punct","subj":"T7103","obj":"T7095"},{"id":"R1720","pred":"prep","subj":"T7104","obj":"T7095"},{"id":"R1721","pred":"pobj","subj":"T7105","obj":"T7104"},{"id":"R1722","pred":"punct","subj":"T7106","obj":"T7105"},{"id":"R1723","pred":"appos","subj":"T7107","obj":"T7105"},{"id":"R1724","pred":"punct","subj":"T7108","obj":"T7095"},{"id":"R1725","pred":"nummod","subj":"T7109","obj":"T7110"},{"id":"R1726","pred":"npadvmod","subj":"T7110","obj":"T7111"},{"id":"R1727","pred":"prep","subj":"T7111","obj":"T7095"},{"id":"R1728","pred":"pobj","subj":"T7112","obj":"T7111"},{"id":"R1729","pred":"cc","subj":"T7113","obj":"T7095"},{"id":"R1730","pred":"det","subj":"T7114","obj":"T7115"},{"id":"R1731","pred":"nsubj","subj":"T7115","obj":"T7117"},{"id":"R1732","pred":"amod","subj":"T7116","obj":"T7115"},{"id":"R1733","pred":"conj","subj":"T7117","obj":"T7095"},{"id":"R1734","pred":"prep","subj":"T7118","obj":"T7117"},{"id":"R1735","pred":"compound","subj":"T7119","obj":"T7120"},{"id":"R1736","pred":"pobj","subj":"T7120","obj":"T7118"},{"id":"R1737","pred":"prep","subj":"T7121","obj":"T7117"},{"id":"R1738","pred":"pobj","subj":"T7122","obj":"T7121"},{"id":"R1739","pred":"punct","subj":"T7123","obj":"T7095"},{"id":"R1740","pred":"mark","subj":"T7125","obj":"T7126"},{"id":"R1741","pred":"advcl","subj":"T7126","obj":"T7127"},{"id":"R1742","pred":"advmod","subj":"T7128","obj":"T7126"},{"id":"R1743","pred":"punct","subj":"T7129","obj":"T7130"},{"id":"R1744","pred":"parataxis","subj":"T7130","obj":"T7126"},{"id":"R1745","pred":"nummod","subj":"T7131","obj":"T7130"},{"id":"R1746","pred":"punct","subj":"T7132","obj":"T7130"},{"id":"R1747","pred":"punct","subj":"T7133","obj":"T7130"},{"id":"R1748","pred":"dep","subj":"T7134","obj":"T7127"},{"id":"R1749","pred":"compound","subj":"T7135","obj":"T7136"},{"id":"R1750","pred":"compound","subj":"T7136","obj":"T7137"},{"id":"R1751","pred":"nsubj","subj":"T7137","obj":"T7127"},{"id":"R1752","pred":"preconj","subj":"T7138","obj":"T7139"},{"id":"R1753","pred":"amod","subj":"T7139","obj":"T7140"},{"id":"R1754","pred":"dobj","subj":"T7140","obj":"T7127"},{"id":"R1755","pred":"cc","subj":"T7141","obj":"T7139"},{"id":"R1756","pred":"conj","subj":"T7142","obj":"T7139"},{"id":"R1757","pred":"amod","subj":"T7143","obj":"T7140"},{"id":"R1758","pred":"compound","subj":"T7144","obj":"T7140"},{"id":"R1759","pred":"punct","subj":"T7145","obj":"T7146"},{"id":"R1760","pred":"parataxis","subj":"T7146","obj":"T7127"},{"id":"R1761","pred":"compound","subj":"T7147","obj":"T7146"},{"id":"R1762","pred":"cc","subj":"T7148","obj":"T7146"},{"id":"R1763","pred":"conj","subj":"T7149","obj":"T7146"},{"id":"R1764","pred":"punct","subj":"T7150","obj":"T7146"},{"id":"R1765","pred":"punct","subj":"T7151","obj":"T7127"},{"id":"R1766","pred":"nsubjpass","subj":"T7153","obj":"T7154"},{"id":"R1767","pred":"auxpass","subj":"T7155","obj":"T7154"},{"id":"R1768","pred":"advmod","subj":"T7156","obj":"T7154"},{"id":"R1769","pred":"prep","subj":"T7157","obj":"T7154"},{"id":"R1770","pred":"pobj","subj":"T7158","obj":"T7157"},{"id":"R1771","pred":"punct","subj":"T7159","obj":"T7158"},{"id":"R1772","pred":"conj","subj":"T7160","obj":"T7158"},{"id":"R1773","pred":"punct","subj":"T7161","obj":"T7160"},{"id":"R1774","pred":"cc","subj":"T7162","obj":"T7160"},{"id":"R1775","pred":"amod","subj":"T7163","obj":"T7164"},{"id":"R1776","pred":"conj","subj":"T7164","obj":"T7160"},{"id":"R1777","pred":"punct","subj":"T7165","obj":"T7164"},{"id":"R1778","pred":"appos","subj":"T7166","obj":"T7164"},{"id":"R1779","pred":"punct","subj":"T7167","obj":"T7164"},{"id":"R1780","pred":"nummod","subj":"T7168","obj":"T7164"},{"id":"R1781","pred":"prep","subj":"T7169","obj":"T7154"},{"id":"R1782","pred":"det","subj":"T7170","obj":"T7171"},{"id":"R1783","pred":"pobj","subj":"T7171","obj":"T7169"},{"id":"R1784","pred":"amod","subj":"T7172","obj":"T7171"},{"id":"R1785","pred":"advmod","subj":"T7173","obj":"T7174"},{"id":"R1786","pred":"relcl","subj":"T7174","obj":"T7171"},{"id":"R1787","pred":"amod","subj":"T7175","obj":"T7176"},{"id":"R1788","pred":"nsubjpass","subj":"T7176","obj":"T7174"},{"id":"R1789","pred":"nmod","subj":"T7177","obj":"T7176"},{"id":"R1790","pred":"punct","subj":"T7178","obj":"T7177"},{"id":"R1791","pred":"nmod","subj":"T7179","obj":"T7176"},{"id":"R1792","pred":"cc","subj":"T7180","obj":"T7179"},{"id":"R1793","pred":"conj","subj":"T7181","obj":"T7179"},{"id":"R1794","pred":"auxpass","subj":"T7182","obj":"T7174"},{"id":"R1795","pred":"punct","subj":"T7183","obj":"T7169"},{"id":"R1796","pred":"cc","subj":"T7184","obj":"T7169"},{"id":"R1797","pred":"conj","subj":"T7185","obj":"T7169"},{"id":"R1798","pred":"det","subj":"T7186","obj":"T7187"},{"id":"R1799","pred":"pobj","subj":"T7187","obj":"T7185"},{"id":"R1800","pred":"amod","subj":"T7188","obj":"T7187"},{"id":"R1801","pred":"prep","subj":"T7189","obj":"T7187"},{"id":"R1802","pred":"det","subj":"T7190","obj":"T7191"},{"id":"R1803","pred":"pobj","subj":"T7191","obj":"T7189"},{"id":"R1804","pred":"compound","subj":"T7192","obj":"T7191"},{"id":"R1805","pred":"punct","subj":"T7193","obj":"T7191"},{"id":"R1806","pred":"advmod","subj":"T7194","obj":"T7195"},{"id":"R1807","pred":"relcl","subj":"T7195","obj":"T7191"},{"id":"R1808","pred":"nmod","subj":"T7196","obj":"T7197"},{"id":"R1809","pred":"nsubj","subj":"T7197","obj":"T7195"},{"id":"R1810","pred":"punct","subj":"T7198","obj":"T7196"},{"id":"R1811","pred":"compound","subj":"T7199","obj":"T7197"},{"id":"R1812","pred":"punct","subj":"T7200","obj":"T7201"},{"id":"R1813","pred":"parataxis","subj":"T7201","obj":"T7154"},{"id":"R1814","pred":"compound","subj":"T7202","obj":"T7203"},{"id":"R1815","pred":"dep","subj":"T7203","obj":"T7201"},{"id":"R1816","pred":"cc","subj":"T7204","obj":"T7203"},{"id":"R1817","pred":"conj","subj":"T7205","obj":"T7203"},{"id":"R1818","pred":"punct","subj":"T7206","obj":"T7201"},{"id":"R1819","pred":"punct","subj":"T7207","obj":"T7201"},{"id":"R1820","pred":"punct","subj":"T7208","obj":"T7209"},{"id":"R1821","pred":"parataxis","subj":"T7209","obj":"T7154"},{"id":"R1822","pred":"punct","subj":"T7210","obj":"T7209"},{"id":"R1823","pred":"punct","subj":"T7211","obj":"T7154"},{"id":"R1824","pred":"amod","subj":"T7213","obj":"T7214"},{"id":"R1825","pred":"nsubj","subj":"T7214","obj":"T7216"},{"id":"R1826","pred":"compound","subj":"T7215","obj":"T7214"},{"id":"R1827","pred":"prep","subj":"T7217","obj":"T7214"},{"id":"R1828","pred":"compound","subj":"T7218","obj":"T7219"},{"id":"R1829","pred":"compound","subj":"T7219","obj":"T7220"},{"id":"R1830","pred":"pobj","subj":"T7220","obj":"T7217"},{"id":"R1831","pred":"advmod","subj":"T7221","obj":"T7222"},{"id":"R1832","pred":"advmod","subj":"T7222","obj":"T7223"},{"id":"R1833","pred":"acomp","subj":"T7223","obj":"T7216"},{"id":"R1834","pred":"prep","subj":"T7224","obj":"T7216"},{"id":"R1835","pred":"pobj","subj":"T7225","obj":"T7224"},{"id":"R1836","pred":"cc","subj":"T7226","obj":"T7225"},{"id":"R1837","pred":"conj","subj":"T7227","obj":"T7225"},{"id":"R1838","pred":"punct","subj":"T7228","obj":"T7225"},{"id":"R1839","pred":"advmod","subj":"T7229","obj":"T7230"},{"id":"R1840","pred":"relcl","subj":"T7230","obj":"T7225"},{"id":"R1841","pred":"nsubjpass","subj":"T7231","obj":"T7230"},{"id":"R1842","pred":"auxpass","subj":"T7232","obj":"T7230"},{"id":"R1843","pred":"prep","subj":"T7233","obj":"T7230"},{"id":"R1844","pred":"amod","subj":"T7234","obj":"T7235"},{"id":"R1845","pred":"nmod","subj":"T7235","obj":"T7237"},{"id":"R1846","pred":"punct","subj":"T7236","obj":"T7235"},{"id":"R1847","pred":"pobj","subj":"T7237","obj":"T7233"},{"id":"R1848","pred":"punct","subj":"T7238","obj":"T7235"},{"id":"R1849","pred":"appos","subj":"T7239","obj":"T7235"},{"id":"R1850","pred":"punct","subj":"T7240","obj":"T7237"},{"id":"R1851","pred":"punct","subj":"T7241","obj":"T7242"},{"id":"R1852","pred":"parataxis","subj":"T7242","obj":"T7216"},{"id":"R1853","pred":"compound","subj":"T7243","obj":"T7242"},{"id":"R1854","pred":"cc","subj":"T7244","obj":"T7242"},{"id":"R1855","pred":"conj","subj":"T7245","obj":"T7242"},{"id":"R1856","pred":"punct","subj":"T7246","obj":"T7242"},{"id":"R1857","pred":"punct","subj":"T7247","obj":"T7216"},{"id":"R1858","pred":"advmod","subj":"T7249","obj":"T7250"},{"id":"R1859","pred":"punct","subj":"T7251","obj":"T7250"},{"id":"R1860","pred":"det","subj":"T7252","obj":"T7253"},{"id":"R1861","pred":"nsubjpass","subj":"T7253","obj":"T7250"},{"id":"R1862","pred":"advmod","subj":"T7254","obj":"T7255"},{"id":"R1863","pred":"amod","subj":"T7255","obj":"T7253"},{"id":"R1864","pred":"compound","subj":"T7256","obj":"T7257"},{"id":"R1865","pred":"compound","subj":"T7257","obj":"T7253"},{"id":"R1866","pred":"punct","subj":"T7258","obj":"T7257"},{"id":"R1867","pred":"prep","subj":"T7259","obj":"T7253"},{"id":"R1868","pred":"pobj","subj":"T7260","obj":"T7259"},{"id":"R1869","pred":"punct","subj":"T7261","obj":"T7260"},{"id":"R1870","pred":"conj","subj":"T7262","obj":"T7260"},{"id":"R1871","pred":"punct","subj":"T7263","obj":"T7262"},{"id":"R1872","pred":"cc","subj":"T7264","obj":"T7262"},{"id":"R1873","pred":"conj","subj":"T7265","obj":"T7262"},{"id":"R1874","pred":"cc","subj":"T7266","obj":"T7253"},{"id":"R1875","pred":"predet","subj":"T7267","obj":"T7268"},{"id":"R1876","pred":"conj","subj":"T7268","obj":"T7253"},{"id":"R1877","pred":"det","subj":"T7269","obj":"T7268"},{"id":"R1878","pred":"amod","subj":"T7270","obj":"T7268"},{"id":"R1879","pred":"prep","subj":"T7271","obj":"T7268"},{"id":"R1880","pred":"pobj","subj":"T7272","obj":"T7271"},{"id":"R1881","pred":"cc","subj":"T7273","obj":"T7272"},{"id":"R1882","pred":"conj","subj":"T7274","obj":"T7272"},{"id":"R1883","pred":"auxpass","subj":"T7275","obj":"T7250"},{"id":"R1884","pred":"advmod","subj":"T7276","obj":"T7250"},{"id":"R1885","pred":"prep","subj":"T7277","obj":"T7250"},{"id":"R1886","pred":"det","subj":"T7278","obj":"T7279"},{"id":"R1887","pred":"pobj","subj":"T7279","obj":"T7277"},{"id":"R1888","pred":"compound","subj":"T7280","obj":"T7281"},{"id":"R1889","pred":"compound","subj":"T7281","obj":"T7283"},{"id":"R1890","pred":"punct","subj":"T7282","obj":"T7281"},{"id":"R1891","pred":"compound","subj":"T7283","obj":"T7279"},{"id":"R1892","pred":"punct","subj":"T7284","obj":"T7285"},{"id":"R1893","pred":"parataxis","subj":"T7285","obj":"T7250"},{"id":"R1894","pred":"compound","subj":"T7286","obj":"T7285"},{"id":"R1895","pred":"punct","subj":"T7287","obj":"T7285"},{"id":"R1896","pred":"conj","subj":"T7288","obj":"T7285"},{"id":"R1897","pred":"punct","subj":"T7289","obj":"T7288"},{"id":"R1898","pred":"conj","subj":"T7290","obj":"T7288"},{"id":"R1899","pred":"punct","subj":"T7291","obj":"T7290"},{"id":"R1900","pred":"conj","subj":"T7292","obj":"T7290"},{"id":"R1901","pred":"punct","subj":"T7293","obj":"T7292"},{"id":"R1902","pred":"cc","subj":"T7294","obj":"T7292"},{"id":"R1903","pred":"conj","subj":"T7295","obj":"T7292"},{"id":"R1904","pred":"punct","subj":"T7296","obj":"T7285"},{"id":"R1905","pred":"punct","subj":"T7297","obj":"T7250"},{"id":"R1906","pred":"prep","subj":"T7299","obj":"T7300"},{"id":"R1907","pred":"pobj","subj":"T7301","obj":"T7299"},{"id":"R1908","pred":"punct","subj":"T7302","obj":"T7300"},{"id":"R1909","pred":"nsubj","subj":"T7303","obj":"T7300"},{"id":"R1910","pred":"prep","subj":"T7304","obj":"T7303"},{"id":"R1911","pred":"pobj","subj":"T7305","obj":"T7304"},{"id":"R1912","pred":"cc","subj":"T7306","obj":"T7305"},{"id":"R1913","pred":"conj","subj":"T7307","obj":"T7305"},{"id":"R1914","pred":"det","subj":"T7308","obj":"T7309"},{"id":"R1915","pred":"dobj","subj":"T7309","obj":"T7300"},{"id":"R1916","pred":"prep","subj":"T7310","obj":"T7300"},{"id":"R1917","pred":"det","subj":"T7311","obj":"T7312"},{"id":"R1918","pred":"pobj","subj":"T7312","obj":"T7310"},{"id":"R1919","pred":"prep","subj":"T7313","obj":"T7312"},{"id":"R1920","pred":"pobj","subj":"T7314","obj":"T7313"},{"id":"R1921","pred":"punct","subj":"T7315","obj":"T7300"},{"id":"R1922","pred":"nsubj","subj":"T7317","obj":"T7318"},{"id":"R1923","pred":"prep","subj":"T7319","obj":"T7317"},{"id":"R1924","pred":"amod","subj":"T7320","obj":"T7321"},{"id":"R1925","pred":"pobj","subj":"T7321","obj":"T7319"},{"id":"R1926","pred":"prep","subj":"T7322","obj":"T7317"},{"id":"R1927","pred":"npadvmod","subj":"T7323","obj":"T7324"},{"id":"R1928","pred":"amod","subj":"T7324","obj":"T7330"},{"id":"R1929","pred":"nummod","subj":"T7325","obj":"T7323"},{"id":"R1930","pred":"punct","subj":"T7326","obj":"T7323"},{"id":"R1931","pred":"appos","subj":"T7327","obj":"T7323"},{"id":"R1932","pred":"punct","subj":"T7328","obj":"T7324"},{"id":"R1933","pred":"punct","subj":"T7329","obj":"T7324"},{"id":"R1934","pred":"pobj","subj":"T7330","obj":"T7322"},{"id":"R1935","pred":"mark","subj":"T7331","obj":"T7332"},{"id":"R1936","pred":"ccomp","subj":"T7332","obj":"T7318"},{"id":"R1937","pred":"nsubj","subj":"T7333","obj":"T7332"},{"id":"R1938","pred":"prep","subj":"T7334","obj":"T7333"},{"id":"R1939","pred":"pobj","subj":"T7335","obj":"T7334"},{"id":"R1940","pred":"punct","subj":"T7336","obj":"T7335"},{"id":"R1941","pred":"cc","subj":"T7337","obj":"T7335"},{"id":"R1942","pred":"neg","subj":"T7338","obj":"T7337"},{"id":"R1943","pred":"conj","subj":"T7339","obj":"T7335"},{"id":"R1944","pred":"cc","subj":"T7340","obj":"T7339"},{"id":"R1945","pred":"conj","subj":"T7341","obj":"T7339"},{"id":"R1946","pred":"punct","subj":"T7342","obj":"T7332"},{"id":"R1947","pred":"amod","subj":"T7343","obj":"T7344"},{"id":"R1948","pred":"dobj","subj":"T7344","obj":"T7332"},{"id":"R1949","pred":"punct","subj":"T7345","obj":"T7346"},{"id":"R1950","pred":"parataxis","subj":"T7346","obj":"T7318"},{"id":"R1951","pred":"compound","subj":"T7347","obj":"T7346"},{"id":"R1952","pred":"punct","subj":"T7348","obj":"T7346"},{"id":"R1953","pred":"punct","subj":"T7349","obj":"T7318"},{"id":"R1954","pred":"csubj","subj":"T7351","obj":"T7352"},{"id":"R1955","pred":"nummod","subj":"T7353","obj":"T7354"},{"id":"R1956","pred":"dobj","subj":"T7354","obj":"T7351"},{"id":"R1957","pred":"compound","subj":"T7355","obj":"T7354"},{"id":"R1958","pred":"advmod","subj":"T7356","obj":"T7352"},{"id":"R1959","pred":"amod","subj":"T7357","obj":"T7358"},{"id":"R1960","pred":"dobj","subj":"T7358","obj":"T7352"},{"id":"R1961","pred":"compound","subj":"T7359","obj":"T7358"},{"id":"R1962","pred":"punct","subj":"T7360","obj":"T7358"},{"id":"R1963","pred":"cc","subj":"T7361","obj":"T7358"},{"id":"R1964","pred":"conj","subj":"T7362","obj":"T7358"},{"id":"R1965","pred":"prep","subj":"T7363","obj":"T7352"},{"id":"R1966","pred":"compound","subj":"T7364","obj":"T7365"},{"id":"R1967","pred":"compound","subj":"T7365","obj":"T7366"},{"id":"R1968","pred":"pobj","subj":"T7366","obj":"T7363"},{"id":"R1969","pred":"punct","subj":"T7367","obj":"T7368"},{"id":"R1970","pred":"parataxis","subj":"T7368","obj":"T7352"},{"id":"R1971","pred":"compound","subj":"T7369","obj":"T7368"},{"id":"R1972","pred":"punct","subj":"T7370","obj":"T7368"},{"id":"R1973","pred":"conj","subj":"T7371","obj":"T7368"},{"id":"R1974","pred":"punct","subj":"T7372","obj":"T7371"},{"id":"R1975","pred":"conj","subj":"T7373","obj":"T7371"},{"id":"R1976","pred":"punct","subj":"T7374","obj":"T7373"},{"id":"R1977","pred":"conj","subj":"T7375","obj":"T7373"},{"id":"R1978","pred":"punct","subj":"T7376","obj":"T7375"},{"id":"R1979","pred":"conj","subj":"T7377","obj":"T7375"},{"id":"R1980","pred":"punct","subj":"T7378","obj":"T7377"},{"id":"R1981","pred":"cc","subj":"T7379","obj":"T7377"},{"id":"R1982","pred":"conj","subj":"T7380","obj":"T7377"},{"id":"R1983","pred":"punct","subj":"T7381","obj":"T7368"},{"id":"R1984","pred":"punct","subj":"T7382","obj":"T7352"},{"id":"R1985","pred":"advcl","subj":"T7383","obj":"T7352"},{"id":"R1986","pred":"mark","subj":"T7384","obj":"T7385"},{"id":"R1987","pred":"ccomp","subj":"T7385","obj":"T7383"},{"id":"R1988","pred":"nsubj","subj":"T7386","obj":"T7385"},{"id":"R1989","pred":"amod","subj":"T7387","obj":"T7388"},{"id":"R1990","pred":"dobj","subj":"T7388","obj":"T7385"},{"id":"R1991","pred":"prep","subj":"T7389","obj":"T7385"},{"id":"R1992","pred":"compound","subj":"T7390","obj":"T7391"},{"id":"R1993","pred":"compound","subj":"T7391","obj":"T7392"},{"id":"R1994","pred":"pobj","subj":"T7392","obj":"T7389"},{"id":"R1995","pred":"prep","subj":"T7393","obj":"T7385"},{"id":"R1996","pred":"det","subj":"T7394","obj":"T7395"},{"id":"R1997","pred":"pobj","subj":"T7395","obj":"T7393"},{"id":"R1998","pred":"dobj","subj":"T7450","obj":"T7448"},{"id":"R1999","pred":"npadvmod","subj":"T7396","obj":"T7397"},{"id":"R2000","pred":"amod","subj":"T7451","obj":"T7450"},{"id":"R2001","pred":"amod","subj":"T7397","obj":"T7395"},{"id":"R2002","pred":"cc","subj":"T7452","obj":"T7451"},{"id":"R2003","pred":"punct","subj":"T7398","obj":"T7397"},{"id":"R2004","pred":"conj","subj":"T7453","obj":"T7451"},{"id":"R2005","pred":"advmod","subj":"T7454","obj":"T7455"},{"id":"R2006","pred":"cc","subj":"T7455","obj":"T7450"},{"id":"R2007","pred":"punct","subj":"T7399","obj":"T7352"},{"id":"R2008","pred":"advmod","subj":"T7456","obj":"T7455"},{"id":"R2009","pred":"amod","subj":"T7457","obj":"T7458"},{"id":"R2010","pred":"det","subj":"T7401","obj":"T7402"},{"id":"R2011","pred":"conj","subj":"T7458","obj":"T7450"},{"id":"R2012","pred":"punct","subj":"T7459","obj":"T7460"},{"id":"R2013","pred":"parataxis","subj":"T7460","obj":"T7448"},{"id":"R2014","pred":"compound","subj":"T7461","obj":"T7460"},{"id":"R2015","pred":"nsubj","subj":"T7402","obj":"T7403"},{"id":"R2016","pred":"punct","subj":"T7462","obj":"T7463"},{"id":"R2017","pred":"prep","subj":"T7463","obj":"T7460"},{"id":"R2018","pred":"prep","subj":"T7404","obj":"T7403"},{"id":"R2019","pred":"punct","subj":"T7464","obj":"T7460"},{"id":"R2020","pred":"punct","subj":"T7465","obj":"T7466"},{"id":"R2021","pred":"parataxis","subj":"T7466","obj":"T7448"},{"id":"R2022","pred":"nummod","subj":"T7467","obj":"T7466"},{"id":"R2023","pred":"amod","subj":"T7405","obj":"T7406"},{"id":"R2024","pred":"punct","subj":"T7468","obj":"T7466"},{"id":"R2025","pred":"punct","subj":"T7469","obj":"T7466"},{"id":"R2026","pred":"pobj","subj":"T7406","obj":"T7404"},{"id":"R2027","pred":"punct","subj":"T7470","obj":"T7437"},{"id":"R2028","pred":"prep","subj":"T7407","obj":"T7403"},{"id":"R2029","pred":"det","subj":"T7472","obj":"T7473"},{"id":"R2030","pred":"nsubj","subj":"T7473","obj":"T7474"},{"id":"R2031","pred":"prep","subj":"T7475","obj":"T7473"},{"id":"R2032","pred":"compound","subj":"T7476","obj":"T7477"},{"id":"R2033","pred":"det","subj":"T7408","obj":"T7409"},{"id":"R2034","pred":"pobj","subj":"T7409","obj":"T7407"},{"id":"R2035","pred":"compound","subj":"T7477","obj":"T7478"},{"id":"R2036","pred":"cc","subj":"T7410","obj":"T7409"},{"id":"R2037","pred":"pobj","subj":"T7478","obj":"T7475"},{"id":"R2038","pred":"acomp","subj":"T7479","obj":"T7474"},{"id":"R2039","pred":"prep","subj":"T7480","obj":"T7474"},{"id":"R2040","pred":"conj","subj":"T7411","obj":"T7409"},{"id":"R2041","pred":"det","subj":"T7481","obj":"T7482"},{"id":"R2042","pred":"prep","subj":"T7412","obj":"T7409"},{"id":"R2043","pred":"pobj","subj":"T7482","obj":"T7480"},{"id":"R2044","pred":"amod","subj":"T7483","obj":"T7482"},{"id":"R2045","pred":"punct","subj":"T7484","obj":"T7474"},{"id":"R2046","pred":"cc","subj":"T7485","obj":"T7474"},{"id":"R2047","pred":"compound","subj":"T7413","obj":"T7414"},{"id":"R2048","pred":"det","subj":"T7486","obj":"T7487"},{"id":"R2049","pred":"nsubjpass","subj":"T7487","obj":"T7488"},{"id":"R2050","pred":"compound","subj":"T7414","obj":"T7415"},{"id":"R2051","pred":"conj","subj":"T7488","obj":"T7474"},{"id":"R2052","pred":"prep","subj":"T7489","obj":"T7487"},{"id":"R2053","pred":"det","subj":"T7490","obj":"T7491"},{"id":"R2054","pred":"pobj","subj":"T7415","obj":"T7412"},{"id":"R2055","pred":"pobj","subj":"T7491","obj":"T7489"},{"id":"R2056","pred":"advmod","subj":"T7492","obj":"T7493"},{"id":"R2057","pred":"punct","subj":"T7416","obj":"T7409"},{"id":"R2058","pred":"cc","subj":"T7493","obj":"T7491"},{"id":"R2059","pred":"advmod","subj":"T7494","obj":"T7493"},{"id":"R2060","pred":"amod","subj":"T7495","obj":"T7496"},{"id":"R2061","pred":"advmod","subj":"T7417","obj":"T7418"},{"id":"R2062","pred":"conj","subj":"T7496","obj":"T7491"},{"id":"R2063","pred":"cc","subj":"T7497","obj":"T7495"},{"id":"R2064","pred":"conj","subj":"T7498","obj":"T7495"},{"id":"R2065","pred":"relcl","subj":"T7418","obj":"T7409"},{"id":"R2066","pred":"aux","subj":"T7499","obj":"T7488"},{"id":"R2067","pred":"auxpass","subj":"T7500","obj":"T7488"},{"id":"R2068","pred":"advmod","subj":"T7501","obj":"T7488"},{"id":"R2069","pred":"nsubj","subj":"T7419","obj":"T7418"},{"id":"R2070","pred":"prep","subj":"T7502","obj":"T7488"},{"id":"R2071","pred":"advmod","subj":"T7503","obj":"T7504"},{"id":"R2072","pred":"prep","subj":"T7420","obj":"T7419"},{"id":"R2073","pred":"pcomp","subj":"T7504","obj":"T7502"},{"id":"R2074","pred":"prep","subj":"T7505","obj":"T7504"},{"id":"R2075","pred":"amod","subj":"T7506","obj":"T7507"},{"id":"R2076","pred":"det","subj":"T7421","obj":"T7422"},{"id":"R2077","pred":"pobj","subj":"T7507","obj":"T7505"},{"id":"R2078","pred":"cc","subj":"T7508","obj":"T7506"},{"id":"R2079","pred":"pobj","subj":"T7422","obj":"T7420"},{"id":"R2080","pred":"compound","subj":"T7509","obj":"T7510"},{"id":"R2081","pred":"npadvmod","subj":"T7510","obj":"T7512"},{"id":"R2082","pred":"punct","subj":"T7511","obj":"T7510"},{"id":"R2083","pred":"conj","subj":"T7512","obj":"T7506"},{"id":"R2084","pred":"punct","subj":"T7513","obj":"T7512"},{"id":"R2085","pred":"punct","subj":"T7514","obj":"T7515"},{"id":"R2086","pred":"amod","subj":"T7423","obj":"T7422"},{"id":"R2087","pred":"parataxis","subj":"T7515","obj":"T7488"},{"id":"R2088","pred":"punct","subj":"T7516","obj":"T7515"},{"id":"R2089","pred":"punct","subj":"T7517","obj":"T7518"},{"id":"R2090","pred":"amod","subj":"T7424","obj":"T7425"},{"id":"R2091","pred":"meta","subj":"T7518","obj":"T7488"},{"id":"R2092","pred":"nmod","subj":"T7519","obj":"T7518"},{"id":"R2093","pred":"dobj","subj":"T7425","obj":"T7418"},{"id":"R2094","pred":"cc","subj":"T7520","obj":"T7518"},{"id":"R2095","pred":"conj","subj":"T7521","obj":"T7518"},{"id":"R2096","pred":"nmod","subj":"T7522","obj":"T7521"},{"id":"R2097","pred":"prep","subj":"T7426","obj":"T7418"},{"id":"R2098","pred":"punct","subj":"T7523","obj":"T7521"},{"id":"R2099","pred":"amod","subj":"T7524","obj":"T7525"},{"id":"R2100","pred":"conj","subj":"T7525","obj":"T7521"},{"id":"R2101","pred":"det","subj":"T7427","obj":"T7428"},{"id":"R2102","pred":"punct","subj":"T7526","obj":"T7525"},{"id":"R2103","pred":"punct","subj":"T7527","obj":"T7488"},{"id":"R2104","pred":"pobj","subj":"T7428","obj":"T7426"},{"id":"R2105","pred":"nsubj","subj":"T7529","obj":"T7530"},{"id":"R2106","pred":"punct","subj":"T7429","obj":"T7430"},{"id":"R2107","pred":"prep","subj":"T7531","obj":"T7529"},{"id":"R2108","pred":"amod","subj":"T7532","obj":"T7533"},{"id":"R2109","pred":"pobj","subj":"T7533","obj":"T7531"},{"id":"R2110","pred":"parataxis","subj":"T7430","obj":"T7418"},{"id":"R2111","pred":"compound","subj":"T7534","obj":"T7535"},{"id":"R2112","pred":"compound","subj":"T7535","obj":"T7533"},{"id":"R2113","pred":"compound","subj":"T7536","obj":"T7533"},{"id":"R2114","pred":"punct","subj":"T7431","obj":"T7432"},{"id":"R2115","pred":"advmod","subj":"T7537","obj":"T7530"},{"id":"R2116","pred":"acomp","subj":"T7538","obj":"T7530"},{"id":"R2117","pred":"prep","subj":"T7432","obj":"T7430"},{"id":"R2118","pred":"prep","subj":"T7539","obj":"T7530"},{"id":"R2119","pred":"pobj","subj":"T7540","obj":"T7539"},{"id":"R2120","pred":"prep","subj":"T7541","obj":"T7540"},{"id":"R2121","pred":"punct","subj":"T7433","obj":"T7430"},{"id":"R2122","pred":"det","subj":"T7542","obj":"T7543"},{"id":"R2123","pred":"pobj","subj":"T7543","obj":"T7541"},{"id":"R2124","pred":"amod","subj":"T7544","obj":"T7543"},{"id":"R2125","pred":"punct","subj":"T7434","obj":"T7403"},{"id":"R2126","pred":"punct","subj":"T7545","obj":"T7546"},{"id":"R2127","pred":"meta","subj":"T7546","obj":"T7530"},{"id":"R2128","pred":"nsubj","subj":"T7436","obj":"T7437"},{"id":"R2129","pred":"nmod","subj":"T7547","obj":"T7546"},{"id":"R2130","pred":"cc","subj":"T7548","obj":"T7546"},{"id":"R2131","pred":"conj","subj":"T7549","obj":"T7546"},{"id":"R2132","pred":"nmod","subj":"T7550","obj":"T7549"},{"id":"R2133","pred":"prep","subj":"T7438","obj":"T7436"},{"id":"R2134","pred":"punct","subj":"T7551","obj":"T7549"},{"id":"R2135","pred":"amod","subj":"T7552","obj":"T7553"},{"id":"R2136","pred":"conj","subj":"T7553","obj":"T7549"},{"id":"R2137","pred":"punct","subj":"T7554","obj":"T7553"},{"id":"R2138","pred":"punct","subj":"T7555","obj":"T7530"},{"id":"R2139","pred":"pobj","subj":"T7439","obj":"T7438"},{"id":"R2140","pred":"prep","subj":"T7440","obj":"T7436"},{"id":"R2141","pred":"det","subj":"T7441","obj":"T7442"},{"id":"R2142","pred":"csubj","subj":"T7557","obj":"T7558"},{"id":"R2143","pred":"pobj","subj":"T7442","obj":"T7440"},{"id":"R2144","pred":"dobj","subj":"T7559","obj":"T7557"},{"id":"R2145","pred":"punct","subj":"T7560","obj":"T7559"},{"id":"R2146","pred":"prep","subj":"T7443","obj":"T7437"},{"id":"R2147","pred":"cc","subj":"T7561","obj":"T7559"},{"id":"R2148","pred":"amod","subj":"T7444","obj":"T7445"},{"id":"R2149","pred":"pobj","subj":"T7445","obj":"T7443"},{"id":"R2150","pred":"compound","subj":"T7446","obj":"T7445"},{"id":"R2153","pred":"punct","subj":"T7447","obj":"T7437"},{"id":"R2155","pred":"advcl","subj":"T7448","obj":"T7437"},{"id":"R2160","pred":"amod","subj":"T7449","obj":"T7450"},{"id":"R2189","pred":"cc","subj":"T7683","obj":"T7682"},{"id":"R2190","pred":"amod","subj":"T7684","obj":"T7685"},{"id":"R2192","pred":"conj","subj":"T7685","obj":"T7682"},{"id":"R2193","pred":"compound","subj":"T7686","obj":"T7685"},{"id":"R2195","pred":"compound","subj":"T7687","obj":"T7685"},{"id":"R2196","pred":"punct","subj":"T7688","obj":"T7685"},{"id":"R2197","pred":"compound","subj":"T7689","obj":"T7685"},{"id":"R2199","pred":"punct","subj":"T7690","obj":"T7685"},{"id":"R2200","pred":"appos","subj":"T7691","obj":"T7685"},{"id":"R2202","pred":"punct","subj":"T7692","obj":"T7681"},{"id":"R2203","pred":"punct","subj":"T7693","obj":"T7678"},{"id":"R2205","pred":"compound","subj":"T7694","obj":"T7695"},{"id":"R2206","pred":"nsubj","subj":"T7695","obj":"T7678"},{"id":"R2207","pred":"advmod","subj":"T7696","obj":"T7678"},{"id":"R2209","pred":"predet","subj":"T7697","obj":"T7698"},{"id":"R2211","pred":"dobj","subj":"T7698","obj":"T7678"},{"id":"R2213","pred":"det","subj":"T7699","obj":"T7698"},{"id":"R2215","pred":"amod","subj":"T7700","obj":"T7698"},{"id":"R2216","pred":"punct","subj":"T7701","obj":"T7678"},{"id":"R2217","pred":"cc","subj":"T7702","obj":"T7678"},{"id":"R2219","pred":"compound","subj":"T7703","obj":"T7704"},{"id":"R2220","pred":"nsubj","subj":"T7704","obj":"T7705"},{"id":"R2221","pred":"conj","subj":"T7705","obj":"T7678"},{"id":"R2223","pred":"det","subj":"T7706","obj":"T7707"},{"id":"R2224","pred":"dobj","subj":"T7707","obj":"T7705"},{"id":"R2226","pred":"punct","subj":"T7708","obj":"T7709"},{"id":"R2227","pred":"parataxis","subj":"T7709","obj":"T7705"},{"id":"R2229","pred":"compound","subj":"T7710","obj":"T7709"},{"id":"R2230","pred":"punct","subj":"T7711","obj":"T7709"},{"id":"R2231","pred":"punct","subj":"T7712","obj":"T7705"},{"id":"R2233","pred":"conj","subj":"T7613","obj":"T7607"},{"id":"R2234","pred":"dep","subj":"T7614","obj":"T7615"},{"id":"R2235","pred":"relcl","subj":"T7615","obj":"T7613"},{"id":"R2236","pred":"det","subj":"T7616","obj":"T7617"},{"id":"R2237","pred":"dobj","subj":"T7617","obj":"T7615"},{"id":"R2238","pred":"compound","subj":"T7618","obj":"T7617"},{"id":"R2239","pred":"cc","subj":"T7619","obj":"T7617"},{"id":"R2240","pred":"conj","subj":"T7620","obj":"T7617"},{"id":"R2241","pred":"punct","subj":"T7621","obj":"T7590"},{"id":"R2242","pred":"amod","subj":"T7623","obj":"T7624"},{"id":"R2243","pred":"nsubjpass","subj":"T7624","obj":"T7629"},{"id":"R2244","pred":"amod","subj":"T7625","obj":"T7624"},{"id":"R2245","pred":"cc","subj":"T7626","obj":"T7625"},{"id":"R2246","pred":"conj","subj":"T7627","obj":"T7625"},{"id":"R2247","pred":"compound","subj":"T7628","obj":"T7624"},{"id":"R2248","pred":"cc","subj":"T7630","obj":"T7624"},{"id":"R2249","pred":"amod","subj":"T7631","obj":"T7632"},{"id":"R2250","pred":"conj","subj":"T7632","obj":"T7624"},{"id":"R2251","pred":"auxpass","subj":"T7633","obj":"T7629"},{"id":"R2252","pred":"advmod","subj":"T7634","obj":"T7629"},{"id":"R2253","pred":"punct","subj":"T7635","obj":"T7629"},{"id":"R2254","pred":"prep","subj":"T7636","obj":"T7629"},{"id":"R2255","pred":"det","subj":"T7637","obj":"T7638"},{"id":"R2256","pred":"pobj","subj":"T7638","obj":"T7636"},{"id":"R2257","pred":"compound","subj":"T7639","obj":"T7640"},{"id":"R2258","pred":"compound","subj":"T7640","obj":"T7638"},{"id":"R2259","pred":"punct","subj":"T7641","obj":"T7642"},{"id":"R2260","pred":"parataxis","subj":"T7642","obj":"T7629"},{"id":"R2261","pred":"compound","subj":"T7643","obj":"T7642"},{"id":"R2262","pred":"punct","subj":"T7644","obj":"T7642"},{"id":"R2263","pred":"punct","subj":"T7645","obj":"T7629"},{"id":"R2264","pred":"prep","subj":"T7647","obj":"T7648"},{"id":"R2265","pred":"det","subj":"T7649","obj":"T7650"},{"id":"R2266","pred":"pobj","subj":"T7650","obj":"T7647"},{"id":"R2267","pred":"compound","subj":"T7651","obj":"T7650"},{"id":"R2268","pred":"punct","subj":"T7652","obj":"T7648"},{"id":"R2269","pred":"nsubjpass","subj":"T7653","obj":"T7648"},{"id":"R2270","pred":"punct","subj":"T7654","obj":"T7653"},{"id":"R2271","pred":"conj","subj":"T7655","obj":"T7653"},{"id":"R2272","pred":"punct","subj":"T7656","obj":"T7655"},{"id":"R2273","pred":"conj","subj":"T7657","obj":"T7655"},{"id":"R2274","pred":"punct","subj":"T7658","obj":"T7657"},{"id":"R2275","pred":"cc","subj":"T7659","obj":"T7657"},{"id":"R2276","pred":"conj","subj":"T7660","obj":"T7657"},{"id":"R2277","pred":"auxpass","subj":"T7661","obj":"T7648"},{"id":"R2278","pred":"prep","subj":"T7662","obj":"T7648"},{"id":"R2279","pred":"compound","subj":"T7663","obj":"T7664"},{"id":"R2280","pred":"pobj","subj":"T7664","obj":"T7662"},{"id":"R2281","pred":"punct","subj":"T7665","obj":"T7648"},{"id":"R2282","pred":"cc","subj":"T7666","obj":"T7648"},{"id":"R2283","pred":"nsubj","subj":"T7667","obj":"T7668"},{"id":"R2284","pred":"conj","subj":"T7668","obj":"T7648"},{"id":"R2285","pred":"punct","subj":"T7669","obj":"T7667"},{"id":"R2286","pred":"conj","subj":"T7670","obj":"T7667"},{"id":"R2287","pred":"punct","subj":"T7671","obj":"T7670"},{"id":"R2288","pred":"cc","subj":"T7672","obj":"T7670"},{"id":"R2289","pred":"conj","subj":"T7673","obj":"T7670"},{"id":"R2290","pred":"acomp","subj":"T7674","obj":"T7668"},{"id":"R2291","pred":"punct","subj":"T7675","obj":"T7668"},{"id":"R2292","pred":"advcl","subj":"T7677","obj":"T7678"},{"id":"R2293","pred":"prep","subj":"T7679","obj":"T7677"},{"id":"R2294","pred":"det","subj":"T7680","obj":"T7681"},{"id":"R2295","pred":"pobj","subj":"T7681","obj":"T7679"},{"id":"R2296","pred":"nmod","subj":"T7682","obj":"T7681"},{"id":"R10316","pred":"compound","subj":"T34416","obj":"T34417"},{"id":"R10317","pred":"nsubj","subj":"T34417","obj":"T34418"},{"id":"R10318","pred":"nmod","subj":"T34419","obj":"T34420"},{"id":"R10319","pred":"dobj","subj":"T34420","obj":"T34418"},{"id":"R10320","pred":"punct","subj":"T34421","obj":"T34419"},{"id":"R10321","pred":"conj","subj":"T34422","obj":"T34419"},{"id":"R10322","pred":"punct","subj":"T34423","obj":"T34422"},{"id":"R10323","pred":"cc","subj":"T34424","obj":"T34422"},{"id":"R10324","pred":"conj","subj":"T34425","obj":"T34422"},{"id":"R10325","pred":"prep","subj":"T34426","obj":"T34418"},{"id":"R10326","pred":"det","subj":"T34427","obj":"T34428"},{"id":"R10327","pred":"pobj","subj":"T34428","obj":"T34426"},{"id":"R10328","pred":"compound","subj":"T34429","obj":"T34430"},{"id":"R10329","pred":"compound","subj":"T34430","obj":"T34428"},{"id":"R10330","pred":"punct","subj":"T34432","obj":"T34433"},{"id":"R10331","pred":"meta","subj":"T34433","obj":"T34434"},{"id":"R10332","pred":"punct","subj":"T34435","obj":"T34433"},{"id":"R10333","pred":"amod","subj":"T34436","obj":"T34437"},{"id":"R10334","pred":"nsubjpass","subj":"T34437","obj":"T34434"},{"id":"R10335","pred":"amod","subj":"T34438","obj":"T34437"},{"id":"R10336","pred":"prep","subj":"T34439","obj":"T34437"},{"id":"R10337","pred":"pobj","subj":"T34440","obj":"T34439"},{"id":"R10338","pred":"prep","subj":"T34441","obj":"T34440"},{"id":"R10339","pred":"det","subj":"T34442","obj":"T34443"},{"id":"R10340","pred":"pobj","subj":"T34443","obj":"T34441"},{"id":"R10341","pred":"amod","subj":"T34444","obj":"T34443"},{"id":"R10342","pred":"cc","subj":"T34445","obj":"T34443"},{"id":"R10343","pred":"conj","subj":"T34446","obj":"T34443"},{"id":"R10344","pred":"auxpass","subj":"T34447","obj":"T34434"},{"id":"R10345","pred":"prep","subj":"T34448","obj":"T34434"},{"id":"R10346","pred":"pobj","subj":"T34449","obj":"T34448"},{"id":"R10347","pred":"punct","subj":"T34450","obj":"T34451"},{"id":"R10348","pred":"parataxis","subj":"T34451","obj":"T34449"},{"id":"R10349","pred":"dep","subj":"T34452","obj":"T34451"},{"id":"R10350","pred":"punct","subj":"T34453","obj":"T34451"},{"id":"R10351","pred":"punct","subj":"T34454","obj":"T34451"},{"id":"R10352","pred":"cc","subj":"T34455","obj":"T34449"},{"id":"R10353","pred":"conj","subj":"T34456","obj":"T34449"},{"id":"R10354","pred":"dep","subj":"T34457","obj":"T34458"},{"id":"R10355","pred":"relcl","subj":"T34458","obj":"T34456"},{"id":"R10356","pred":"compound","subj":"T34459","obj":"T34460"},{"id":"R10357","pred":"dobj","subj":"T34460","obj":"T34458"},{"id":"R10358","pred":"punct","subj":"T34461","obj":"T34462"},{"id":"R10359","pred":"parataxis","subj":"T34462","obj":"T34460"},{"id":"R10360","pred":"dep","subj":"T34463","obj":"T34462"},{"id":"R10361","pred":"punct","subj":"T34464","obj":"T34462"},{"id":"R10362","pred":"punct","subj":"T34465","obj":"T34462"},{"id":"R10363","pred":"punct","subj":"T34466","obj":"T34460"},{"id":"R10364","pred":"conj","subj":"T34467","obj":"T34460"},{"id":"R10365","pred":"cc","subj":"T34468","obj":"T34467"},{"id":"R10366","pred":"conj","subj":"T34469","obj":"T34467"},{"id":"R10367","pred":"punct","subj":"T34470","obj":"T34471"},{"id":"R10368","pred":"parataxis","subj":"T34471","obj":"T34469"},{"id":"R10369","pred":"dep","subj":"T34472","obj":"T34471"},{"id":"R10370","pred":"punct","subj":"T34473","obj":"T34471"},{"id":"R10371","pred":"compound","subj":"T34474","obj":"T34475"},{"id":"R10372","pred":"dep","subj":"T34475","obj":"T34471"},{"id":"R10373","pred":"punct","subj":"T34476","obj":"T34471"},{"id":"R10374","pred":"punct","subj":"T34477","obj":"T34471"},{"id":"R10375","pred":"punct","subj":"T34478","obj":"T34471"},{"id":"R10376","pred":"punct","subj":"T34479","obj":"T34467"},{"id":"R10377","pred":"cc","subj":"T34480","obj":"T34467"},{"id":"R10378","pred":"nmod","subj":"T34481","obj":"T34482"},{"id":"R10379","pred":"conj","subj":"T34482","obj":"T34467"},{"id":"R10380","pred":"amod","subj":"T34483","obj":"T34482"},{"id":"R10381","pred":"punct","subj":"T34484","obj":"T34485"},{"id":"R10382","pred":"parataxis","subj":"T34485","obj":"T34482"},{"id":"R10383","pred":"dep","subj":"T34486","obj":"T34485"},{"id":"R10384","pred":"punct","subj":"T34487","obj":"T34485"},{"id":"R10385","pred":"punct","subj":"T34488","obj":"T34485"},{"id":"R10386","pred":"cc","subj":"T34489","obj":"T34485"},{"id":"R10387","pred":"dep","subj":"T34490","obj":"T34491"},{"id":"R10388","pred":"conj","subj":"T34491","obj":"T34485"},{"id":"R10389","pred":"punct","subj":"T34492","obj":"T34491"},{"id":"R10390","pred":"punct","subj":"T34493","obj":"T34491"},{"id":"R10391","pred":"punct","subj":"T34494","obj":"T34434"},{"id":"R10392","pred":"compound","subj":"T34496","obj":"T34497"},{"id":"R10393","pred":"nsubj","subj":"T34497","obj":"T34498"},{"id":"R10394","pred":"nummod","subj":"T34499","obj":"T34500"},{"id":"R10395","pred":"attr","subj":"T34500","obj":"T34498"},{"id":"R10396","pred":"punct","subj":"T34501","obj":"T34498"},{"id":"R10397","pred":"punct","subj":"T34503","obj":"T34504"},{"id":"R10398","pred":"meta","subj":"T34504","obj":"T34505"},{"id":"R10399","pred":"punct","subj":"T34506","obj":"T34504"},{"id":"R10400","pred":"prep","subj":"T34507","obj":"T34505"},{"id":"R10401","pred":"nmod","subj":"T34508","obj":"T34509"},{"id":"R10402","pred":"pobj","subj":"T34509","obj":"T34507"},{"id":"R10403","pred":"punct","subj":"T34510","obj":"T34508"},{"id":"R10404","pred":"compound","subj":"T34511","obj":"T34509"},{"id":"R10405","pred":"punct","subj":"T34512","obj":"T34505"},{"id":"R10406","pred":"punct","subj":"T34514","obj":"T34515"},{"id":"R10407","pred":"meta","subj":"T34515","obj":"T34516"},{"id":"R10408","pred":"punct","subj":"T34517","obj":"T34515"},{"id":"R10409","pred":"prep","subj":"T34518","obj":"T34516"},{"id":"R10410","pred":"nmod","subj":"T34519","obj":"T34520"},{"id":"R10411","pred":"pobj","subj":"T34520","obj":"T34518"},{"id":"R10412","pred":"punct","subj":"T34521","obj":"T34519"},{"id":"R10413","pred":"cc","subj":"T34522","obj":"T34519"},{"id":"R10414","pred":"conj","subj":"T34523","obj":"T34519"},{"id":"R10415","pred":"punct","subj":"T34524","obj":"T34523"},{"id":"R10416","pred":"amod","subj":"T34525","obj":"T34520"},{"id":"R10417","pred":"punct","subj":"T34526","obj":"T34516"},{"id":"R10418","pred":"punct","subj":"T34528","obj":"T34529"},{"id":"R10419","pred":"meta","subj":"T34529","obj":"T34530"},{"id":"R10420","pred":"punct","subj":"T34531","obj":"T34529"},{"id":"R10421","pred":"prep","subj":"T34532","obj":"T34530"},{"id":"R10422","pred":"det","subj":"T34533","obj":"T34534"},{"id":"R10423","pred":"pobj","subj":"T34534","obj":"T34532"},{"id":"R10424","pred":"punct","subj":"T34535","obj":"T34534"},{"id":"R10425","pred":"dep","subj":"T34536","obj":"T34537"},{"id":"R10426","pred":"relcl","subj":"T34537","obj":"T34534"},{"id":"R10427","pred":"det","subj":"T34538","obj":"T34539"},{"id":"R10428","pred":"dobj","subj":"T34539","obj":"T34537"},{"id":"R10429","pred":"prep","subj":"T34540","obj":"T34539"},{"id":"R10430","pred":"pobj","subj":"T34541","obj":"T34540"},{"id":"R10431","pred":"punct","subj":"T34542","obj":"T34530"},{"id":"R10432","pred":"compound","subj":"T34544","obj":"T34545"},{"id":"R10433","pred":"nsubj","subj":"T34545","obj":"T34546"},{"id":"R10434","pred":"dobj","subj":"T34547","obj":"T34546"},{"id":"R10435","pred":"prep","subj":"T34548","obj":"T34547"},{"id":"R10436","pred":"pobj","subj":"T34549","obj":"T34548"},{"id":"R10437","pred":"prep","subj":"T34550","obj":"T34549"},{"id":"R10438","pred":"nummod","subj":"T34551","obj":"T34552"},{"id":"R10439","pred":"pobj","subj":"T34552","obj":"T34550"},{"id":"R10440","pred":"punct","subj":"T34553","obj":"T34546"},{"id":"R10441","pred":"cc","subj":"T34554","obj":"T34546"},{"id":"R10442","pred":"nsubj","subj":"T34555","obj":"T34556"},{"id":"R10443","pred":"conj","subj":"T34556","obj":"T34546"},{"id":"R10444","pred":"det","subj":"T34557","obj":"T34558"},{"id":"R10445","pred":"dobj","subj":"T34558","obj":"T34556"},{"id":"R10446","pred":"amod","subj":"T34559","obj":"T34558"},{"id":"R10447","pred":"prep","subj":"T34560","obj":"T34558"},{"id":"R10448","pred":"pobj","subj":"T34561","obj":"T34560"},{"id":"R10449","pred":"prep","subj":"T34562","obj":"T34561"},{"id":"R10450","pred":"pobj","subj":"T34563","obj":"T34562"},{"id":"R10451","pred":"cc","subj":"T34564","obj":"T34563"},{"id":"R10452","pred":"det","subj":"T34565","obj":"T34566"},{"id":"R10453","pred":"nmod","subj":"T34566","obj":"T34567"},{"id":"R10454","pred":"conj","subj":"T34567","obj":"T34563"},{"id":"R10455","pred":"punct","subj":"T34568","obj":"T34556"},{"id":"R10456","pred":"mark","subj":"T34569","obj":"T34570"},{"id":"R10457","pred":"advcl","subj":"T34570","obj":"T34556"},{"id":"R10458","pred":"advmod","subj":"T34571","obj":"T34570"},{"id":"R10459","pred":"agent","subj":"T34572","obj":"T34570"},{"id":"R10460","pred":"amod","subj":"T34573","obj":"T34574"},{"id":"R10461","pred":"pobj","subj":"T34574","obj":"T34572"},{"id":"R10462","pred":"punct","subj":"T34575","obj":"T34576"},{"id":"R10463","pred":"parataxis","subj":"T34576","obj":"T34556"},{"id":"R10464","pred":"punct","subj":"T34577","obj":"T34578"},{"id":"R10465","pred":"ccomp","subj":"T34578","obj":"T34576"},{"id":"R10466","pred":"punct","subj":"T34579","obj":"T34578"},{"id":"R10467","pred":"nsubj","subj":"T34580","obj":"T34578"},{"id":"R10468","pred":"punct","subj":"T34581","obj":"T34578"},{"id":"R10469","pred":"punct","subj":"T34582","obj":"T34576"},{"id":"R10470","pred":"punct","subj":"T34583","obj":"T34584"},{"id":"R10471","pred":"ccomp","subj":"T34584","obj":"T34576"},{"id":"R10472","pred":"punct","subj":"T34585","obj":"T34584"},{"id":"R10473","pred":"nsubj","subj":"T34586","obj":"T34584"},{"id":"R10474","pred":"punct","subj":"T34587","obj":"T34584"},{"id":"R10475","pred":"punct","subj":"T34588","obj":"T34576"},{"id":"R10476","pred":"nmod","subj":"T34589","obj":"T34576"},{"id":"R10477","pred":"cc","subj":"T34590","obj":"T34589"},{"id":"R10478","pred":"compound","subj":"T34591","obj":"T34592"},{"id":"R10479","pred":"conj","subj":"T34592","obj":"T34589"},{"id":"R10480","pred":"punct","subj":"T34593","obj":"T34576"},{"id":"R10481","pred":"punct","subj":"T34594","obj":"T34556"},{"id":"R10482","pred":"punct","subj":"T34596","obj":"T34597"},{"id":"R10483","pred":"meta","subj":"T34597","obj":"T34598"},{"id":"R10484","pred":"cc","subj":"T34599","obj":"T34597"},{"id":"R10485","pred":"conj","subj":"T34600","obj":"T34597"},{"id":"R10486","pred":"punct","subj":"T34601","obj":"T34600"},{"id":"R10487","pred":"nsubjpass","subj":"T34602","obj":"T34598"},{"id":"R10488","pred":"auxpass","subj":"T34603","obj":"T34598"},{"id":"R10489","pred":"prep","subj":"T34604","obj":"T34598"},{"id":"R10490","pred":"det","subj":"T34605","obj":"T34606"},{"id":"R10491","pred":"pobj","subj":"T34606","obj":"T34604"},{"id":"R10492","pred":"amod","subj":"T34607","obj":"T34606"},{"id":"R10493","pred":"prep","subj":"T34608","obj":"T34598"},{"id":"R10494","pred":"npadvmod","subj":"T34609","obj":"T34610"},{"id":"R10495","pred":"amod","subj":"T34610","obj":"T34612"},{"id":"R10496","pred":"punct","subj":"T34611","obj":"T34610"},{"id":"R10497","pred":"pobj","subj":"T34612","obj":"T34608"},{"id":"R10498","pred":"punct","subj":"T34613","obj":"T34614"},{"id":"R10499","pred":"parataxis","subj":"T34614","obj":"T34610"},{"id":"R10500","pred":"punct","subj":"T34615","obj":"T34614"},{"id":"R10501","pred":"punct","subj":"T34616","obj":"T34598"},{"id":"R10502","pred":"cc","subj":"T34617","obj":"T34598"},{"id":"R10503","pred":"punct","subj":"T34618","obj":"T34619"},{"id":"R10504","pred":"parataxis","subj":"T34619","obj":"T34620"},{"id":"R10505","pred":"nsubjpass","subj":"T34620","obj":"T34623"},{"id":"R10506","pred":"punct","subj":"T34621","obj":"T34619"},{"id":"R10507","pred":"compound","subj":"T34622","obj":"T34620"},{"id":"R10508","pred":"conj","subj":"T34623","obj":"T34598"},{"id":"R10509","pred":"cc","subj":"T34624","obj":"T34620"},{"id":"R10510","pred":"punct","subj":"T34625","obj":"T34626"},{"id":"R10511","pred":"parataxis","subj":"T34626","obj":"T34627"},{"id":"R10512","pred":"conj","subj":"T34627","obj":"T34620"},{"id":"R10513","pred":"punct","subj":"T34628","obj":"T34626"},{"id":"R10514","pred":"compound","subj":"T34629","obj":"T34630"},{"id":"R10515","pred":"compound","subj":"T34630","obj":"T34627"},{"id":"R10516","pred":"punct","subj":"T34631","obj":"T34630"},{"id":"R10517","pred":"prep","subj":"T34632","obj":"T34620"},{"id":"R10518","pred":"det","subj":"T34633","obj":"T34634"},{"id":"R10519","pred":"pobj","subj":"T34634","obj":"T34632"},{"id":"R10520","pred":"prep","subj":"T34635","obj":"T34634"},{"id":"R10521","pred":"det","subj":"T34636","obj":"T34637"},{"id":"R10522","pred":"pobj","subj":"T34637","obj":"T34635"},{"id":"R10523","pred":"prep","subj":"T34638","obj":"T34637"},{"id":"R10524","pred":"det","subj":"T34639","obj":"T34640"},{"id":"R10525","pred":"pobj","subj":"T34640","obj":"T34638"},{"id":"R10526","pred":"compound","subj":"T34641","obj":"T34640"},{"id":"R10527","pred":"auxpass","subj":"T34642","obj":"T34623"},{"id":"R10528","pred":"punct","subj":"T34643","obj":"T34623"},{"id":"R10529","pred":"punct","subj":"T34645","obj":"T34646"},{"id":"R10530","pred":"nsubj","subj":"T34647","obj":"T34646"},{"id":"R10531","pred":"punct","subj":"T34648","obj":"T34646"},{"id":"R10532","pred":"advmod","subj":"T34649","obj":"T34646"},{"id":"R10533","pred":"mark","subj":"T34650","obj":"T34651"},{"id":"R10534","pred":"ccomp","subj":"T34651","obj":"T34646"},{"id":"R10535","pred":"det","subj":"T34652","obj":"T34653"},{"id":"R10536","pred":"nsubj","subj":"T34653","obj":"T34651"},{"id":"R10537","pred":"amod","subj":"T34654","obj":"T34653"},{"id":"R10538","pred":"prep","subj":"T34655","obj":"T34653"},{"id":"R10539","pred":"det","subj":"T34656","obj":"T34657"},{"id":"R10540","pred":"pobj","subj":"T34657","obj":"T34655"},{"id":"R10541","pred":"prep","subj":"T34658","obj":"T34653"},{"id":"R10542","pred":"det","subj":"T34659","obj":"T34660"},{"id":"R10543","pred":"pobj","subj":"T34660","obj":"T34658"},{"id":"R10544","pred":"punct","subj":"T34661","obj":"T34660"},{"id":"R10545","pred":"acl","subj":"T34662","obj":"T34660"},{"id":"R10546","pred":"agent","subj":"T34663","obj":"T34662"},{"id":"R10547","pred":"det","subj":"T34664","obj":"T34665"},{"id":"R10548","pred":"pobj","subj":"T34665","obj":"T34663"},{"id":"R10549","pred":"amod","subj":"T34666","obj":"T34665"},{"id":"R10550","pred":"compound","subj":"T34667","obj":"T34668"},{"id":"R10551","pred":"compound","subj":"T34668","obj":"T34665"},{"id":"R10552","pred":"punct","subj":"T34669","obj":"T34668"},{"id":"R10553","pred":"punct","subj":"T34670","obj":"T34671"},{"id":"R10554","pred":"parataxis","subj":"T34671","obj":"T34662"},{"id":"R10555","pred":"amod","subj":"T34672","obj":"T34671"},{"id":"R10556","pred":"punct","subj":"T34673","obj":"T34671"},{"id":"R10557","pred":"neg","subj":"T34674","obj":"T34651"},{"id":"R10558","pred":"advmod","subj":"T34675","obj":"T34676"},{"id":"R10559","pred":"acomp","subj":"T34676","obj":"T34651"},{"id":"R10560","pred":"prep","subj":"T34677","obj":"T34676"},{"id":"R10561","pred":"poss","subj":"T34678","obj":"T34679"},{"id":"R10562","pred":"pobj","subj":"T34679","obj":"T34677"},{"id":"R10563","pred":"prep","subj":"T34680","obj":"T34679"},{"id":"R10564","pred":"det","subj":"T34681","obj":"T34682"},{"id":"R10565","pred":"pobj","subj":"T34682","obj":"T34680"},{"id":"R10566","pred":"compound","subj":"T34683","obj":"T34684"},{"id":"R10567","pred":"compound","subj":"T34684","obj":"T34682"},{"id":"R10568","pred":"punct","subj":"T34685","obj":"T34684"},{"id":"R10569","pred":"punct","subj":"T34686","obj":"T34679"},{"id":"R10570","pred":"acl","subj":"T34687","obj":"T34679"},{"id":"R10571","pred":"agent","subj":"T34688","obj":"T34687"},{"id":"R10572","pred":"det","subj":"T34689","obj":"T34690"},{"id":"R10573","pred":"pobj","subj":"T34690","obj":"T34688"},{"id":"R10574","pred":"punct","subj":"T34691","obj":"T34692"},{"id":"R10575","pred":"parataxis","subj":"T34692","obj":"T34690"},{"id":"R10576","pred":"amod","subj":"T34693","obj":"T34692"},{"id":"R10577","pred":"punct","subj":"T34694","obj":"T34692"},{"id":"R10578","pred":"prep","subj":"T34695","obj":"T34690"},{"id":"R10579","pred":"det","subj":"T34696","obj":"T34697"},{"id":"R10580","pred":"pobj","subj":"T34697","obj":"T34695"},{"id":"R10581","pred":"amod","subj":"T34698","obj":"T34697"},{"id":"R10582","pred":"prep","subj":"T34699","obj":"T34697"},{"id":"R10583","pred":"nummod","subj":"T34700","obj":"T34701"},{"id":"R10584","pred":"pobj","subj":"T34701","obj":"T34699"},{"id":"R10585","pred":"nmod","subj":"T34702","obj":"T34701"},{"id":"R10586","pred":"punct","subj":"T34703","obj":"T34701"},{"id":"R10587","pred":"punct","subj":"T34704","obj":"T34705"},{"id":"R10588","pred":"prep","subj":"T34705","obj":"T34701"},{"id":"R10589","pred":"punct","subj":"T34706","obj":"T34646"},{"id":"R2151","pred":"neg","subj":"T7562","obj":"T7561"},{"id":"R2152","pred":"conj","subj":"T7563","obj":"T7559"},{"id":"R2154","pred":"cc","subj":"T7564","obj":"T7563"},{"id":"R2156","pred":"conj","subj":"T7565","obj":"T7563"},{"id":"R2157","pred":"punct","subj":"T7566","obj":"T7558"},{"id":"R2158","pred":"det","subj":"T7567","obj":"T7568"},{"id":"R2159","pred":"dobj","subj":"T7568","obj":"T7558"},{"id":"R2161","pred":"amod","subj":"T7569","obj":"T7568"},{"id":"R2162","pred":"compound","subj":"T7570","obj":"T7568"},{"id":"R2164","pred":"prep","subj":"T7571","obj":"T7558"},{"id":"R2165","pred":"det","subj":"T7572","obj":"T7573"},{"id":"R2166","pred":"pobj","subj":"T7573","obj":"T7571"},{"id":"R2167","pred":"npadvmod","subj":"T7574","obj":"T7575"},{"id":"R2168","pred":"amod","subj":"T7575","obj":"T7573"},{"id":"R2170","pred":"punct","subj":"T7576","obj":"T7575"},{"id":"R2171","pred":"punct","subj":"T7577","obj":"T7578"},{"id":"R2173","pred":"parataxis","subj":"T7578","obj":"T7558"},{"id":"R2174","pred":"compound","subj":"T7579","obj":"T7578"},{"id":"R2175","pred":"punct","subj":"T7580","obj":"T7578"},{"id":"R2176","pred":"conj","subj":"T7581","obj":"T7578"},{"id":"R2178","pred":"punct","subj":"T7582","obj":"T7581"},{"id":"R2179","pred":"cc","subj":"T7583","obj":"T7581"},{"id":"R2180","pred":"conj","subj":"T7584","obj":"T7581"},{"id":"R2182","pred":"punct","subj":"T7585","obj":"T7578"},{"id":"R2183","pred":"punct","subj":"T7586","obj":"T7558"},{"id":"R2163","pred":"aux","subj":"T7588","obj":"T7589"},{"id":"R2169","pred":"advcl","subj":"T7589","obj":"T7590"},{"id":"R2172","pred":"det","subj":"T7591","obj":"T7592"},{"id":"R2177","pred":"dobj","subj":"T7592","obj":"T7589"},{"id":"R2181","pred":"amod","subj":"T7593","obj":"T7592"},{"id":"R2184","pred":"dep","subj":"T7594","obj":"T7595"},{"id":"R2185","pred":"relcl","subj":"T7595","obj":"T7592"},{"id":"R2186","pred":"det","subj":"T7596","obj":"T7597"},{"id":"R2187","pred":"dobj","subj":"T7597","obj":"T7595"},{"id":"R2188","pred":"amod","subj":"T7598","obj":"T7597"},{"id":"R2191","pred":"prep","subj":"T7599","obj":"T7597"},{"id":"R2194","pred":"pobj","subj":"T7600","obj":"T7599"},{"id":"R2198","pred":"punct","subj":"T7601","obj":"T7590"},{"id":"R2201","pred":"nsubj","subj":"T7602","obj":"T7590"},{"id":"R2204","pred":"det","subj":"T7603","obj":"T7604"},{"id":"R2208","pred":"dobj","subj":"T7604","obj":"T7590"},{"id":"R2210","pred":"prep","subj":"T7605","obj":"T7604"},{"id":"R2212","pred":"amod","subj":"T7606","obj":"T7607"},{"id":"R2214","pred":"pobj","subj":"T7607","obj":"T7605"},{"id":"R2218","pred":"compound","subj":"T7608","obj":"T7607"},{"id":"R2222","pred":"advmod","subj":"T7609","obj":"T7610"},{"id":"R2225","pred":"cc","subj":"T7610","obj":"T7607"},{"id":"R2228","pred":"advmod","subj":"T7611","obj":"T7610"},{"id":"R2232","pred":"amod","subj":"T7612","obj":"T7613"}],"text":"Rb Regulates Division and Death through E2f1\nWe used the α-Cre transgene to delete floxed Rb exon 19 at embryonic day (E) 10 in peripheral retina [2]. RbloxP/loxP;α-Cre mice were bred with strains lacking E2f1 or E2f2 in the germ line, or a strain carrying a floxed E2f3 allele [5]. RbloxP/loxP;E2f1+/− and RbloxP/loxP;E2f1+/−;α-Cre mice were bred to produce RbloxP/loxP;E2f1−/−;α-Cre mice at a frequency of 1/8 and littermate controls at the same or higher (1/4) frequency. For simplicity we will refer to the RbloxP/loxP;E2f1−/−;α-Cre peripheral retina as the Rb/E2f1 double knockout (DKO) retina. Similar strategies were employed in the case of E2f2 or E2f3. Cre-mediated excision of Rb and E2f3 alleles in the retina was confirmed by PCR as described previously [2,5].\nTo measure ectopic cell division, mice were pulse-labelled with bromodeoxyuridine (BrdU) 2 h before sacrifice and the peripheral retina analyzed for BrdU incorporation by immunofluorescence. As reported before [2,3], Rb KO retinas exhibited both spatial and temporal ectopic DNA synthesis (Figures 1C and S1A). This is easily detected at E14, E16, and postnatal day (P) 0 in the inner retina where abnormal BrdU+ ganglion and amacrine RTCs are located, or on the outermost region of the P0 retina, where BrdU+ photoreceptor RTCs reside (Figures S1A and S2, arrows) [2]. Ectopic RTC division in Rb KO retinas is even more obvious at P8 or P18, when division is completed in wild-type (WT) retina (Figures 1C and S1A). Strikingly, the ectopically positioned S-phase cells at E14, E16, and P0 and all the abnormal division at P8 and P18 were completely suppressed in the Rb/E2f1 DKO retina (Figures 1C, 1E, 1F, S1A, and S2). In contrast, deletion of E2f2 or E2f3 had no effect at any stage of development. Analysis of mitotic cells with anti–phosphohistone 3 (PH3)–specific antibodies confirmed that loss of E2f1, but not E2f2 or E2f3, suppressed ectopic division (Figure S3). Deleting one E2f1 allele partially suppressed ectopic S-phase and mitosis in Rb KO RTCs (Figures 1C, 1E, 1F, S1A, S2, and S3), suggesting that E2f1 drives ectopic division in Rb KO RTCs in a dose-dependent fashion. These data contrast with previous findings in the lens and CNS of Rb KO embryos, where deletion of any activating E2f suppresses ectopic division to some extent [6–9].\nLoss of Rb in the retina results in considerable RTC apoptosis, eliminating most bipolar and ganglion cells as well as many rods (Figure 2A–2D) [2,3]. The loss of Rb KO rods is evident from the thinner ONL, and the death of these cells as well as bipolar and ganglion neurons can be detected directly by double labelling for apoptotic and cell-type-specific markers [2] (M. P. and R. B., unpublished data). Loss of peripheral Rb KO ganglion cells is also evident from thinning of the optic nerve (D. C. and R. B., unpublished data). Deleting E2f1, but not E2f2 or E2f3, blocked this ectopic cell death in a dose-dependent fashion (Figures 1D, 1G, and S1B).\nFigure 2 E2f1 Deletion Rescues Ganglion, Rod, and Bipolar Cells in the Rb KO Retina\n(A) Horizontal retinal sections from mice of the indicated ages and genotypes were stained for nuclei (DAPI, blue) and markers that detect ganglion cells (Pou4f2, red), rods and cones (Sag [rod arrestin], green), and rod bipolar cells (Prkca, green, and Cabp5, red). Scale bars are 50 μm.\n(B) Quantification of Pou4f2+ ganglion cells.\n(C) Quantification of Prkca+ and Cabp5+ bipolar cells.\n(D) Thickness of the ONL, which represents the number of rods.\nError bars represent SD of measurements from three animals, and asterisks indicate a significant difference between retinas of WT and the indicated genotypes, unless indicated otherwise by connecting lines (*, p \u003c 0.05; **; p \u003c 0.01; ANOVA and Tukey HSD test).\n(E and F) ERGs were recorded from the indicated genotypes under dark-adapted (scotopic) conditions, and (E) intensity series and (F) b-wave amplitudes as a function of the logarithm of the flash intensity were determined. (F) Further illustrates that the relative influence of the mutations on the photoreceptors (indicated by the saturated a-wave amplitude, right graph) was not substantially different from their effect on the b-wave response (dominated by the bipolars, left graph) at the same intensity of 10 cd·s/m2. To investigate the molecular mechanism that underlies the unique role of E2f1, we assessed the expression of known E2f targets as well as other genes that regulate the cell cycle and apoptosis. Numerous positive and negative cell cycle and apoptotic regulators were up-regulated in the Rb KO retina (Figure 1H). Among the E2f family, E2f1, E2f2, E2f3a, and E2f7 were induced following Rb loss, but E2f3b, E2f4, and E2f5 were unaffected. Consistent with the BrdU and terminal dUTP nick-end labelling (TUNEL) analyses, E2f1 deletion specifically reversed all these molecular defects, but E2f3 deletion had no effect (Figure 1H)."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6707","span":{"begin":0,"end":2},"obj":"PR_EXT:000013773"},{"id":"T6708","span":{"begin":3,"end":12},"obj":"GO:0065007"},{"id":"T6709","span":{"begin":26,"end":31},"obj":"GO:0016265"},{"id":"T6710","span":{"begin":40,"end":44},"obj":"PR_EXT:000006852"},{"id":"T6711","span":{"begin":63,"end":72},"obj":"SO_EXT:0000902"},{"id":"T6712","span":{"begin":76,"end":82},"obj":"SO_EXT:sequence_deletion_process"},{"id":"T6713","span":{"begin":83,"end":89},"obj":"SO:0000359"},{"id":"T6714","span":{"begin":90,"end":92},"obj":"PR_EXT:000013773"},{"id":"T6715","span":{"begin":93,"end":97},"obj":"SO_EXT:0000147"},{"id":"T6716","span":{"begin":104,"end":113},"obj":"UBERON:0000922"},{"id":"T6717","span":{"begin":128,"end":145},"obj":"UBERON:0013682"},{"id":"T6718","span":{"begin":151,"end":153},"obj":"PR_EXT:000013773"},{"id":"T6719","span":{"begin":153,"end":157},"obj":"SO_EXT:0000346"},{"id":"T6720","span":{"begin":158,"end":162},"obj":"SO_EXT:0000346"},{"id":"T6721","span":{"begin":169,"end":173},"obj":"NCBITaxon:10088"},{"id":"T6722","span":{"begin":179,"end":183},"obj":"GO_EXT:breeding"},{"id":"T6723","span":{"begin":205,"end":209},"obj":"PR_EXT:000006852"},{"id":"T6724","span":{"begin":213,"end":217},"obj":"PR_EXT:000006853"},{"id":"T6725","span":{"begin":259,"end":265},"obj":"SO:0000359"},{"id":"T6726","span":{"begin":266,"end":270},"obj":"PR_EXT:000006854"},{"id":"T6727","span":{"begin":271,"end":277},"obj":"SO_EXT:0001023"},{"id":"T6728","span":{"begin":283,"end":285},"obj":"PR_EXT:000013773"},{"id":"T6729","span":{"begin":285,"end":289},"obj":"SO_EXT:0000346"},{"id":"T6730","span":{"begin":290,"end":294},"obj":"SO_EXT:0000346"},{"id":"T6731","span":{"begin":295,"end":299},"obj":"PR_EXT:000006852"},{"id":"T6732","span":{"begin":299,"end":300},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T6733","span":{"begin":301,"end":302},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6734","span":{"begin":307,"end":309},"obj":"PR_EXT:000013773"},{"id":"T6735","span":{"begin":309,"end":313},"obj":"SO_EXT:0000346"},{"id":"T6736","span":{"begin":314,"end":318},"obj":"SO_EXT:0000346"},{"id":"T6737","span":{"begin":319,"end":323},"obj":"PR_EXT:000006852"},{"id":"T6738","span":{"begin":323,"end":324},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T6739","span":{"begin":325,"end":326},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6740","span":{"begin":333,"end":337},"obj":"NCBITaxon:10088"},{"id":"T6741","span":{"begin":343,"end":347},"obj":"GO_EXT:breeding"},{"id":"T6742","span":{"begin":359,"end":361},"obj":"PR_EXT:000013773"},{"id":"T6743","span":{"begin":361,"end":365},"obj":"SO_EXT:0000346"},{"id":"T6744","span":{"begin":366,"end":370},"obj":"SO_EXT:0000346"},{"id":"T6745","span":{"begin":371,"end":375},"obj":"PR_EXT:000006852"},{"id":"T6746","span":{"begin":375,"end":376},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6747","span":{"begin":377,"end":378},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6748","span":{"begin":385,"end":389},"obj":"NCBITaxon:10088"},{"id":"T6749","span":{"begin":511,"end":513},"obj":"PR_EXT:000013773"},{"id":"T6750","span":{"begin":513,"end":517},"obj":"SO_EXT:0000346"},{"id":"T6751","span":{"begin":518,"end":522},"obj":"SO_EXT:0000346"},{"id":"T6752","span":{"begin":523,"end":527},"obj":"PR_EXT:000006852"},{"id":"T6753","span":{"begin":527,"end":528},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6754","span":{"begin":529,"end":530},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T6755","span":{"begin":537,"end":554},"obj":"UBERON:0013682"},{"id":"T6756","span":{"begin":562,"end":564},"obj":"PR_EXT:000013773"},{"id":"T6757","span":{"begin":565,"end":569},"obj":"PR_EXT:000006852"},{"id":"T6758","span":{"begin":592,"end":598},"obj":"UBERON:0000966"},{"id":"T6759","span":{"begin":648,"end":652},"obj":"PR_EXT:000006853"},{"id":"T6760","span":{"begin":656,"end":660},"obj":"PR_EXT:000006854"},{"id":"T6761","span":{"begin":675,"end":683},"obj":"SO_EXT:sequence_deletion_process"},{"id":"T6762","span":{"begin":687,"end":689},"obj":"PR_EXT:000013773"},{"id":"T6763","span":{"begin":694,"end":698},"obj":"PR_EXT:000006854"},{"id":"T6764","span":{"begin":699,"end":706},"obj":"SO_EXT:0001023"},{"id":"T6765","span":{"begin":714,"end":720},"obj":"UBERON:0000966"},{"id":"T6766","span":{"begin":792,"end":796},"obj":"CL_GO_EXT:cell"},{"id":"T6767","span":{"begin":792,"end":805},"obj":"GO:0051301"},{"id":"T6768","span":{"begin":807,"end":811},"obj":"NCBITaxon:10088"},{"id":"T6769","span":{"begin":823,"end":831},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T6770","span":{"begin":837,"end":854},"obj":"CHEBI:472552"},{"id":"T6771","span":{"begin":856,"end":860},"obj":"CHEBI:472552"},{"id":"T6772","span":{"begin":873,"end":882},"obj":"GO_EXT:killing"},{"id":"T6773","span":{"begin":891,"end":908},"obj":"UBERON:0013682"},{"id":"T6774","span":{"begin":922,"end":926},"obj":"CHEBI:472552"},{"id":"T6775","span":{"begin":990,"end":992},"obj":"PR_EXT:000013773"},{"id":"T6776","span":{"begin":996,"end":1003},"obj":"UBERON:0000966"},{"id":"T6777","span":{"begin":1048,"end":1051},"obj":"CHEBI_SO_EXT:DNA"},{"id":"T6778","span":{"begin":1048,"end":1061},"obj":"GO:0071897"},{"id":"T6779","span":{"begin":1129,"end":1134},"obj":"GO:0007567"},{"id":"T6780","span":{"begin":1158,"end":1164},"obj":"UBERON:0000966"},{"id":"T6781","span":{"begin":1180,"end":1184},"obj":"CHEBI:472552"},{"id":"T6795","span":{"begin":1644,"end":1648},"obj":"PR_EXT:000006852"},{"id":"T6796","span":{"begin":1653,"end":1659},"obj":"UBERON:0000966"},{"id":"T6797","span":{"begin":1708,"end":1716},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T6798","span":{"begin":1720,"end":1724},"obj":"PR_EXT:000006853"},{"id":"T6799","span":{"begin":1728,"end":1732},"obj":"PR_EXT:000006854"},{"id":"T6800","span":{"begin":1788,"end":1795},"obj":"GO:0007067"},{"id":"T6801","span":{"begin":1796,"end":1801},"obj":"CL_GO_EXT:cell"},{"id":"T6802","span":{"begin":1812,"end":1826},"obj":"CHEBI_EXT:phosphohistone"},{"id":"T6803","span":{"begin":1844,"end":1854},"obj":"GO:0042571"},{"id":"T6804","span":{"begin":1878,"end":1882},"obj":"PR_EXT:000006852"},{"id":"T6805","span":{"begin":1892,"end":1896},"obj":"PR_EXT:000006853"},{"id":"T6806","span":{"begin":1900,"end":1904},"obj":"PR_EXT:000006854"},{"id":"T6807","span":{"begin":1947,"end":1955},"obj":"SO_EXT:sequence_deletion_process"},{"id":"T6808","span":{"begin":1960,"end":1964},"obj":"PR_EXT:000006852"},{"id":"T6809","span":{"begin":1965,"end":1971},"obj":"SO_EXT:0001023"},{"id":"T6810","span":{"begin":2001,"end":2008},"obj":"GO:0051320"},{"id":"T6811","span":{"begin":2013,"end":2020},"obj":"GO:0007067"},{"id":"T6812","span":{"begin":2024,"end":2026},"obj":"PR_EXT:000013773"},{"id":"T6813","span":{"begin":2090,"end":2094},"obj":"PR_EXT:000006852"},{"id":"T6814","span":{"begin":2122,"end":2124},"obj":"PR_EXT:000013773"},{"id":"T6815","span":{"begin":2212,"end":2216},"obj":"UBERON_EXT:lens"},{"id":"T6816","span":{"begin":2221,"end":2224},"obj":"UBERON:0001017"},{"id":"T6817","span":{"begin":2228,"end":2230},"obj":"PR_EXT:000013773"},{"id":"T6818","span":{"begin":2234,"end":2241},"obj":"UBERON:0000922"},{"id":"T6819","span":{"begin":2249,"end":2257},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T6820","span":{"begin":2276,"end":2279},"obj":"PR_EXT:E2F"},{"id":"T6821","span":{"begin":2338,"end":2340},"obj":"PR_EXT:000013773"},{"id":"T6822","span":{"begin":2348,"end":2354},"obj":"UBERON:0000966"},{"id":"T6823","span":{"begin":2383,"end":2392},"obj":"GO:0006915"},{"id":"T6824","span":{"begin":2394,"end":2405},"obj":"GO_EXT:killing"},{"id":"T6825","span":{"begin":2411,"end":2418},"obj":"_FRAGMENT"},{"id":"T6826","span":{"begin":2432,"end":2437},"obj":"CL:0000103"},{"id":"T6827","span":{"begin":2423,"end":2431},"obj":"UBERON:0000045"},{"id":"T6828","span":{"begin":2423,"end":2437},"obj":"CL:0000740"},{"id":"T6829","span":{"begin":2432,"end":2437},"obj":"CL_GO_EXT:cell"},{"id":"T6830","span":{"begin":2454,"end":2458},"obj":"CL:0000604"},{"id":"T6831","span":{"begin":2493,"end":2495},"obj":"PR_EXT:000013773"},{"id":"T6832","span":{"begin":2499,"end":2503},"obj":"CL:0000604"},{"id":"T6833","span":{"begin":2532,"end":2535},"obj":"UBERON:0001789"},{"id":"T6834","span":{"begin":2545,"end":2553},"obj":"_FRAGMENT"},{"id":"T6835","span":{"begin":2560,"end":2565},"obj":"GO:0008219"},{"id":"T6836","span":{"begin":2560,"end":2565},"obj":"CL_GO_EXT:cell"},{"id":"T6837","span":{"begin":2577,"end":2584},"obj":"_FRAGMENT"},{"id":"T6838","span":{"begin":2598,"end":2605},"obj":"CL:0000103"},{"id":"T6839","span":{"begin":2589,"end":2597},"obj":"UBERON:0000045"},{"id":"T6840","span":{"begin":2589,"end":2605},"obj":"CL:0000740"},{"id":"T6841","span":{"begin":2641,"end":2650},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T6842","span":{"begin":2655,"end":2664},"obj":"GO_PATO_EXT:apoptotic_process_or_quality"},{"id":"T6843","span":{"begin":2669,"end":2673},"obj":"CL_GO_EXT:cell"},{"id":"T6844","span":{"begin":2688,"end":2695},"obj":"CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag"},{"id":"T6845","span":{"begin":2756,"end":2758},"obj":"PR_EXT:000013773"},{"id":"T6846","span":{"begin":2762,"end":2770},"obj":"UBERON:0000045"},{"id":"T6847","span":{"begin":2762,"end":2776},"obj":"CL:0000740"},{"id":"T6848","span":{"begin":2771,"end":2776},"obj":"CL_GO_EXT:cell"},{"id":"T6849","span":{"begin":2814,"end":2825},"obj":"UBERON_EXT:optic_nerve"},{"id":"T6850","span":{"begin":2863,"end":2871},"obj":"SO_EXT:sequence_deletion_process"},{"id":"T6851","span":{"begin":2872,"end":2876},"obj":"PR_EXT:000006852"},{"id":"T6852","span":{"begin":2886,"end":2890},"obj":"PR_EXT:000006853"},{"id":"T6853","span":{"begin":2894,"end":2898},"obj":"PR_EXT:000006854"},{"id":"T6854","span":{"begin":2921,"end":2925},"obj":"CL_GO_EXT:cell"},{"id":"T6855","span":{"begin":2921,"end":2931},"obj":"GO:0008219"},{"id":"T34375","span":{"begin":3065,"end":3071},"obj":"UBERON:0000966"},{"id":"T34376","span":{"begin":3087,"end":3094},"obj":"UBERON:0000966"},{"id":"T34377","span":{"begin":3109,"end":3113},"obj":"NCBITaxon:10088"},{"id":"T34364","span":{"begin":2997,"end":3001},"obj":"PR_EXT:000006852"},{"id":"T34365","span":{"begin":3002,"end":3010},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T34366","span":{"begin":3011,"end":3018},"obj":"SO_EXT:sequence_rescue_process"},{"id":"T34367","span":{"begin":3019,"end":3027},"obj":"UBERON:0000045"},{"id":"T34368","span":{"begin":3019,"end":3027},"obj":"_FRAGMENT"},{"id":"T34369","span":{"begin":3046,"end":3051},"obj":"CL:0000740"},{"id":"T34370","span":{"begin":3029,"end":3032},"obj":"_FRAGMENT"},{"id":"T34371","span":{"begin":3046,"end":3051},"obj":"CL:0000604"},{"id":"T34372","span":{"begin":3038,"end":3051},"obj":"CL:0000748"},{"id":"T34373","span":{"begin":3046,"end":3051},"obj":"CL_GO_EXT:cell"},{"id":"T34374","span":{"begin":3059,"end":3061},"obj":"PR_EXT:000013773"},{"id":"T34378","span":{"begin":3140,"end":3149},"obj":"SO_EXT:genotype_or_entity_with_genotype"},{"id":"T34379","span":{"begin":3167,"end":3173},"obj":"GO:0005634"},{"id":"T34380","span":{"begin":3175,"end":3179},"obj":"CHEBI:51231"},{"id":"T34381","span":{"begin":3191,"end":3198},"obj":"CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag"},{"id":"T34382","span":{"begin":3211,"end":3219},"obj":"UBERON:0000045"},{"id":"T34383","span":{"begin":3211,"end":3225},"obj":"CL:0000740"},{"id":"T34384","span":{"begin":3220,"end":3225},"obj":"CL_GO_EXT:cell"},{"id":"T34385","span":{"begin":3227,"end":3233},"obj":"PR_EXT:000013042"},{"id":"T34386","span":{"begin":3241,"end":3245},"obj":"CL:0000604"},{"id":"T34387","span":{"begin":3250,"end":3255},"obj":"CL:0000573"},{"id":"T34388","span":{"begin":3257,"end":3260},"obj":"PR_EXT:000014434"},{"id":"T34389","span":{"begin":3262,"end":3265},"obj":"CL:0000604"},{"id":"T34390","span":{"begin":3262,"end":3274},"obj":"PR_EXT:000014434"},{"id":"T34391","span":{"begin":3289,"end":3306},"obj":"CL:0000751"},{"id":"T34392","span":{"begin":3301,"end":3306},"obj":"CL_GO_EXT:cell"},{"id":"T34393","span":{"begin":3308,"end":3313},"obj":"PR_EXT:000003058"},{"id":"T34394","span":{"begin":3326,"end":3331},"obj":"PR_EXT:000004937"},{"id":"T34395","span":{"begin":3383,"end":3389},"obj":"PR_EXT:000013042"},{"id":"T34396","span":{"begin":3391,"end":3399},"obj":"UBERON:0000045"},{"id":"T34397","span":{"begin":3391,"end":3405},"obj":"CL:0000740"},{"id":"T34398","span":{"begin":3400,"end":3405},"obj":"CL_GO_EXT:cell"},{"id":"T34399","span":{"begin":3429,"end":3434},"obj":"PR_EXT:000003058"},{"id":"T34400","span":{"begin":3440,"end":3445},"obj":"PR_EXT:000004937"},{"id":"T34401","span":{"begin":3447,"end":3460},"obj":"CL:0000103"},{"id":"T34402","span":{"begin":3455,"end":3460},"obj":"CL_GO_EXT:cell"},{"id":"T34403","span":{"begin":3483,"end":3486},"obj":"UBERON:0001789"},{"id":"T34404","span":{"begin":3519,"end":3523},"obj":"CL:0000604"},{"id":"T34405","span":{"begin":3576,"end":3583},"obj":"NCBITaxon:33208"},{"id":"T34406","span":{"begin":3641,"end":3648},"obj":"UBERON:0000966"},{"id":"T34407","span":{"begin":3652,"end":3654},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T34408","span":{"begin":3673,"end":3682},"obj":"SO_EXT:genotype_or_entity_with_genotype"},{"id":"T34409","span":{"begin":3834,"end":3843},"obj":"SO_EXT:genotype_or_entity_with_genotype"},{"id":"T34410","span":{"begin":3850,"end":3862},"obj":"GO:1990603"},{"id":"T34411","span":{"begin":3864,"end":3872},"obj":"GO:1990603"},{"id":"T34412","span":{"begin":4067,"end":4076},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T34413","span":{"begin":4084,"end":4098},"obj":"CL:0000210"},{"id":"T34414","span":{"begin":4222,"end":4230},"obj":"GO_EXT:reaction_or_response"},{"id":"T34415","span":{"begin":4249,"end":4257},"obj":"CL:0000103"},{"id":"T6782","span":{"begin":1186,"end":1194},"obj":"UBERON:0000045"},{"id":"T6783","span":{"begin":1199,"end":1207},"obj":"CL:0000561"},{"id":"T6784","span":{"begin":1263,"end":1269},"obj":"UBERON:0000966"},{"id":"T6785","span":{"begin":1277,"end":1281},"obj":"CHEBI:472552"},{"id":"T6786","span":{"begin":1283,"end":1296},"obj":"CL:0000210"},{"id":"T6787","span":{"begin":1367,"end":1369},"obj":"PR_EXT:000013773"},{"id":"T6788","span":{"begin":1373,"end":1380},"obj":"UBERON:0000966"},{"id":"T6789","span":{"begin":1446,"end":1455},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T6790","span":{"begin":1457,"end":1459},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T6791","span":{"begin":1461,"end":1467},"obj":"UBERON:0000966"},{"id":"T6792","span":{"begin":1529,"end":1536},"obj":"GO:0051320"},{"id":"T6793","span":{"begin":1537,"end":1542},"obj":"CL_GO_EXT:cell"},{"id":"T6794","span":{"begin":1641,"end":1643},"obj":"PR_EXT:000013773"},{"id":"T6856","span":{"begin":4327,"end":4336},"obj":"CHEBI_EXT:polyatomic_entity_or_group"},{"id":"T6857","span":{"begin":4381,"end":4385},"obj":"PR_EXT:000006852"},{"id":"T6858","span":{"begin":4403,"end":4413},"obj":"GO:0010467"},{"id":"T6859","span":{"begin":4423,"end":4426},"obj":"PR_EXT:E2F"},{"id":"T6860","span":{"begin":4452,"end":4457},"obj":"SO_EXT:0000704"},{"id":"T6861","span":{"begin":4463,"end":4471},"obj":"GO:0065007"},{"id":"T6862","span":{"begin":4476,"end":4480},"obj":"CL_GO_EXT:cell"},{"id":"T6863","span":{"begin":4476,"end":4486},"obj":"GO:0007049"},{"id":"T6864","span":{"begin":4491,"end":4500},"obj":"GO:0006915"},{"id":"T6865","span":{"begin":4533,"end":4537},"obj":"CL_GO_EXT:cell"},{"id":"T6866","span":{"begin":4533,"end":4543},"obj":"GO:0007049"},{"id":"T6867","span":{"begin":4548,"end":4557},"obj":"GO_PATO_EXT:apoptotic_process_or_quality"},{"id":"T6868","span":{"begin":4558,"end":4568},"obj":"GO_EXT:regulator"},{"id":"T6869","span":{"begin":4574,"end":4586},"obj":"GO_EXT:positive_regulation"},{"id":"T6870","span":{"begin":4594,"end":4596},"obj":"PR_EXT:000013773"},{"id":"T6871","span":{"begin":4600,"end":4606},"obj":"UBERON:0000966"},{"id":"T6872","span":{"begin":4630,"end":4633},"obj":"PR_EXT:E2F"},{"id":"T6873","span":{"begin":4642,"end":4646},"obj":"PR_EXT:000006852"},{"id":"T6874","span":{"begin":4648,"end":4652},"obj":"PR_EXT:000006853"},{"id":"T6875","span":{"begin":4654,"end":4659},"obj":"PR_EXT:000028775"},{"id":"T6876","span":{"begin":4665,"end":4669},"obj":"PR_EXT:000006858"},{"id":"T6877","span":{"begin":4693,"end":4695},"obj":"PR_EXT:000013773"},{"id":"T6878","span":{"begin":4713,"end":4717},"obj":"PR_EXT:000006855"},{"id":"T6879","span":{"begin":4723,"end":4727},"obj":"PR_EXT:000006856"},{"id":"T6880","span":{"begin":4765,"end":4769},"obj":"CHEBI:472552"},{"id":"T6881","span":{"begin":4783,"end":4787},"obj":"CHEBI_EXT:dUTP"},{"id":"T6882","span":{"begin":4797,"end":4806},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T6883","span":{"begin":4825,"end":4829},"obj":"PR_EXT:000006852"},{"id":"T6884","span":{"begin":4830,"end":4838},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T6885","span":{"begin":4871,"end":4880},"obj":"CHEBI_EXT:polyatomic_entity_or_group"},{"id":"T6886","span":{"begin":4894,"end":4898},"obj":"PR_EXT:000006854"},{"id":"T6887","span":{"begin":4899,"end":4907},"obj":"SO_EXT:sequence_deletion_entity_or_process"}],"relations":[{"id":"R10314","pred":"_lexicallyChainedTo","subj":"T34369","obj":"T34368"},{"id":"R10315","pred":"_lexicallyChainedTo","subj":"T34371","obj":"T34370"},{"id":"R1516","pred":"_lexicallyChainedTo","subj":"T6826","obj":"T6825"},{"id":"R1517","pred":"_lexicallyChainedTo","subj":"T6835","obj":"T6834"},{"id":"R1518","pred":"_lexicallyChainedTo","subj":"T6838","obj":"T6837"}],"text":"Rb Regulates Division and Death through E2f1\nWe used the α-Cre transgene to delete floxed Rb exon 19 at embryonic day (E) 10 in peripheral retina [2]. RbloxP/loxP;α-Cre mice were bred with strains lacking E2f1 or E2f2 in the germ line, or a strain carrying a floxed E2f3 allele [5]. RbloxP/loxP;E2f1+/− and RbloxP/loxP;E2f1+/−;α-Cre mice were bred to produce RbloxP/loxP;E2f1−/−;α-Cre mice at a frequency of 1/8 and littermate controls at the same or higher (1/4) frequency. For simplicity we will refer to the RbloxP/loxP;E2f1−/−;α-Cre peripheral retina as the Rb/E2f1 double knockout (DKO) retina. Similar strategies were employed in the case of E2f2 or E2f3. Cre-mediated excision of Rb and E2f3 alleles in the retina was confirmed by PCR as described previously [2,5].\nTo measure ectopic cell division, mice were pulse-labelled with bromodeoxyuridine (BrdU) 2 h before sacrifice and the peripheral retina analyzed for BrdU incorporation by immunofluorescence. As reported before [2,3], Rb KO retinas exhibited both spatial and temporal ectopic DNA synthesis (Figures 1C and S1A). This is easily detected at E14, E16, and postnatal day (P) 0 in the inner retina where abnormal BrdU+ ganglion and amacrine RTCs are located, or on the outermost region of the P0 retina, where BrdU+ photoreceptor RTCs reside (Figures S1A and S2, arrows) [2]. Ectopic RTC division in Rb KO retinas is even more obvious at P8 or P18, when division is completed in wild-type (WT) retina (Figures 1C and S1A). Strikingly, the ectopically positioned S-phase cells at E14, E16, and P0 and all the abnormal division at P8 and P18 were completely suppressed in the Rb/E2f1 DKO retina (Figures 1C, 1E, 1F, S1A, and S2). In contrast, deletion of E2f2 or E2f3 had no effect at any stage of development. Analysis of mitotic cells with anti–phosphohistone 3 (PH3)–specific antibodies confirmed that loss of E2f1, but not E2f2 or E2f3, suppressed ectopic division (Figure S3). Deleting one E2f1 allele partially suppressed ectopic S-phase and mitosis in Rb KO RTCs (Figures 1C, 1E, 1F, S1A, S2, and S3), suggesting that E2f1 drives ectopic division in Rb KO RTCs in a dose-dependent fashion. These data contrast with previous findings in the lens and CNS of Rb KO embryos, where deletion of any activating E2f suppresses ectopic division to some extent [6–9].\nLoss of Rb in the retina results in considerable RTC apoptosis, eliminating most bipolar and ganglion cells as well as many rods (Figure 2A–2D) [2,3]. The loss of Rb KO rods is evident from the thinner ONL, and the death of these cells as well as bipolar and ganglion neurons can be detected directly by double labelling for apoptotic and cell-type-specific markers [2] (M. P. and R. B., unpublished data). Loss of peripheral Rb KO ganglion cells is also evident from thinning of the optic nerve (D. C. and R. B., unpublished data). Deleting E2f1, but not E2f2 or E2f3, blocked this ectopic cell death in a dose-dependent fashion (Figures 1D, 1G, and S1B).\nFigure 2 E2f1 Deletion Rescues Ganglion, Rod, and Bipolar Cells in the Rb KO Retina\n(A) Horizontal retinal sections from mice of the indicated ages and genotypes were stained for nuclei (DAPI, blue) and markers that detect ganglion cells (Pou4f2, red), rods and cones (Sag [rod arrestin], green), and rod bipolar cells (Prkca, green, and Cabp5, red). Scale bars are 50 μm.\n(B) Quantification of Pou4f2+ ganglion cells.\n(C) Quantification of Prkca+ and Cabp5+ bipolar cells.\n(D) Thickness of the ONL, which represents the number of rods.\nError bars represent SD of measurements from three animals, and asterisks indicate a significant difference between retinas of WT and the indicated genotypes, unless indicated otherwise by connecting lines (*, p \u003c 0.05; **; p \u003c 0.01; ANOVA and Tukey HSD test).\n(E and F) ERGs were recorded from the indicated genotypes under dark-adapted (scotopic) conditions, and (E) intensity series and (F) b-wave amplitudes as a function of the logarithm of the flash intensity were determined. (F) Further illustrates that the relative influence of the mutations on the photoreceptors (indicated by the saturated a-wave amplitude, right graph) was not substantially different from their effect on the b-wave response (dominated by the bipolars, left graph) at the same intensity of 10 cd·s/m2. To investigate the molecular mechanism that underlies the unique role of E2f1, we assessed the expression of known E2f targets as well as other genes that regulate the cell cycle and apoptosis. Numerous positive and negative cell cycle and apoptotic regulators were up-regulated in the Rb KO retina (Figure 1H). Among the E2f family, E2f1, E2f2, E2f3a, and E2f7 were induced following Rb loss, but E2f3b, E2f4, and E2f5 were unaffected. Consistent with the BrdU and terminal dUTP nick-end labelling (TUNEL) analyses, E2f1 deletion specifically reversed all these molecular defects, but E2f3 deletion had no effect (Figure 1H)."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T6616","span":{"begin":648,"end":652},"obj":"PR:000006853"},{"id":"T6617","span":{"begin":656,"end":660},"obj":"PR:000006854"},{"id":"T6618","span":{"begin":687,"end":689},"obj":"PR:000013773"},{"id":"T6619","span":{"begin":694,"end":698},"obj":"PR:000006854"},{"id":"T6620","span":{"begin":699,"end":706},"obj":"SO:0001023"},{"id":"T6621","span":{"begin":714,"end":720},"obj":"UBERON:0000966"},{"id":"T6622","span":{"begin":792,"end":805},"obj":"GO:0051301"},{"id":"T6623","span":{"begin":807,"end":811},"obj":"NCBITaxon:10088"},{"id":"T6624","span":{"begin":837,"end":854},"obj":"CHEBI:472552"},{"id":"T6625","span":{"begin":856,"end":860},"obj":"CHEBI:472552"},{"id":"T6626","span":{"begin":891,"end":908},"obj":"UBERON:0013682"},{"id":"T6627","span":{"begin":922,"end":926},"obj":"CHEBI:472552"},{"id":"T6628","span":{"begin":990,"end":992},"obj":"PR:000013773"},{"id":"T6575","span":{"begin":0,"end":2},"obj":"PR:000013773"},{"id":"T6576","span":{"begin":3,"end":12},"obj":"GO:0065007"},{"id":"T6577","span":{"begin":26,"end":31},"obj":"GO:0016265"},{"id":"T6578","span":{"begin":40,"end":44},"obj":"PR:000006852"},{"id":"T6579","span":{"begin":63,"end":72},"obj":"SO:0000902"},{"id":"T6580","span":{"begin":83,"end":89},"obj":"SO:0000359"},{"id":"T6581","span":{"begin":90,"end":92},"obj":"PR:000013773"},{"id":"T6582","span":{"begin":93,"end":97},"obj":"SO:0000147"},{"id":"T6583","span":{"begin":104,"end":113},"obj":"UBERON:0000922"},{"id":"T6584","span":{"begin":128,"end":145},"obj":"UBERON:0013682"},{"id":"T6585","span":{"begin":151,"end":153},"obj":"PR:000013773"},{"id":"T6586","span":{"begin":153,"end":157},"obj":"SO:0000346"},{"id":"T6587","span":{"begin":158,"end":162},"obj":"SO:0000346"},{"id":"T6588","span":{"begin":169,"end":173},"obj":"NCBITaxon:10088"},{"id":"T6589","span":{"begin":205,"end":209},"obj":"PR:000006852"},{"id":"T6590","span":{"begin":213,"end":217},"obj":"PR:000006853"},{"id":"T6591","span":{"begin":259,"end":265},"obj":"SO:0000359"},{"id":"T6592","span":{"begin":266,"end":270},"obj":"PR:000006854"},{"id":"T6593","span":{"begin":271,"end":277},"obj":"SO:0001023"},{"id":"T6594","span":{"begin":283,"end":285},"obj":"PR:000013773"},{"id":"T6595","span":{"begin":285,"end":289},"obj":"SO:0000346"},{"id":"T6596","span":{"begin":290,"end":294},"obj":"SO:0000346"},{"id":"T6597","span":{"begin":295,"end":299},"obj":"PR:000006852"},{"id":"T6598","span":{"begin":307,"end":309},"obj":"PR:000013773"},{"id":"T6599","span":{"begin":309,"end":313},"obj":"SO:0000346"},{"id":"T6600","span":{"begin":314,"end":318},"obj":"SO:0000346"},{"id":"T6601","span":{"begin":319,"end":323},"obj":"PR:000006852"},{"id":"T6602","span":{"begin":333,"end":337},"obj":"NCBITaxon:10088"},{"id":"T6603","span":{"begin":359,"end":361},"obj":"PR:000013773"},{"id":"T6604","span":{"begin":361,"end":365},"obj":"SO:0000346"},{"id":"T6605","span":{"begin":366,"end":370},"obj":"SO:0000346"},{"id":"T6606","span":{"begin":371,"end":375},"obj":"PR:000006852"},{"id":"T6607","span":{"begin":385,"end":389},"obj":"NCBITaxon:10088"},{"id":"T6608","span":{"begin":511,"end":513},"obj":"PR:000013773"},{"id":"T6609","span":{"begin":513,"end":517},"obj":"SO:0000346"},{"id":"T6610","span":{"begin":518,"end":522},"obj":"SO:0000346"},{"id":"T6611","span":{"begin":523,"end":527},"obj":"PR:000006852"},{"id":"T6612","span":{"begin":537,"end":554},"obj":"UBERON:0013682"},{"id":"T6613","span":{"begin":562,"end":564},"obj":"PR:000013773"},{"id":"T6614","span":{"begin":565,"end":569},"obj":"PR:000006852"},{"id":"T6615","span":{"begin":592,"end":598},"obj":"UBERON:0000966"},{"id":"T6629","span":{"begin":996,"end":1003},"obj":"UBERON:0000966"},{"id":"T6630","span":{"begin":1048,"end":1061},"obj":"GO:0071897"},{"id":"T6631","span":{"begin":1129,"end":1134},"obj":"GO:0007567"},{"id":"T6632","span":{"begin":1158,"end":1164},"obj":"UBERON:0000966"},{"id":"T6633","span":{"begin":1180,"end":1184},"obj":"CHEBI:472552"},{"id":"T6670","span":{"begin":2454,"end":2458},"obj":"CL:0000604"},{"id":"T6671","span":{"begin":2493,"end":2495},"obj":"PR:000013773"},{"id":"T6672","span":{"begin":2499,"end":2503},"obj":"CL:0000604"},{"id":"T6673","span":{"begin":2532,"end":2535},"obj":"UBERON:0001789"},{"id":"T6674","span":{"begin":2545,"end":2553},"obj":"_FRAGMENT"},{"id":"T6675","span":{"begin":2560,"end":2565},"obj":"GO:0008219"},{"id":"T6676","span":{"begin":2577,"end":2584},"obj":"_FRAGMENT"},{"id":"T6677","span":{"begin":2598,"end":2605},"obj":"CL:0000103"},{"id":"T6678","span":{"begin":2589,"end":2597},"obj":"UBERON:0000045"},{"id":"T6679","span":{"begin":2589,"end":2605},"obj":"CL:0000740"},{"id":"T6680","span":{"begin":2756,"end":2758},"obj":"PR:000013773"},{"id":"T6681","span":{"begin":2762,"end":2770},"obj":"UBERON:0000045"},{"id":"T6682","span":{"begin":2762,"end":2776},"obj":"CL:0000740"},{"id":"T6683","span":{"begin":2814,"end":2819},"obj":"UBERON:0000970"},{"id":"T6684","span":{"begin":2872,"end":2876},"obj":"PR:000006852"},{"id":"T6685","span":{"begin":2886,"end":2890},"obj":"PR:000006853"},{"id":"T6686","span":{"begin":2894,"end":2898},"obj":"PR:000006854"},{"id":"T6687","span":{"begin":2921,"end":2931},"obj":"GO:0008219"},{"id":"T34326","span":{"begin":2997,"end":3001},"obj":"PR:000006852"},{"id":"T34327","span":{"begin":3019,"end":3027},"obj":"UBERON:0000045"},{"id":"T34328","span":{"begin":3019,"end":3027},"obj":"_FRAGMENT"},{"id":"T34329","span":{"begin":3046,"end":3051},"obj":"CL:0000740"},{"id":"T34330","span":{"begin":3029,"end":3032},"obj":"_FRAGMENT"},{"id":"T34331","span":{"begin":3046,"end":3051},"obj":"CL:0000604"},{"id":"T34332","span":{"begin":3038,"end":3051},"obj":"CL:0000748"},{"id":"T34333","span":{"begin":3059,"end":3061},"obj":"PR:000013773"},{"id":"T34334","span":{"begin":3065,"end":3071},"obj":"UBERON:0000966"},{"id":"T34335","span":{"begin":3087,"end":3094},"obj":"UBERON:0000966"},{"id":"T34336","span":{"begin":3109,"end":3113},"obj":"NCBITaxon:10088"},{"id":"T34337","span":{"begin":3167,"end":3173},"obj":"GO:0005634"},{"id":"T34338","span":{"begin":3175,"end":3179},"obj":"CHEBI:51231"},{"id":"T34339","span":{"begin":3211,"end":3219},"obj":"UBERON:0000045"},{"id":"T34340","span":{"begin":3211,"end":3225},"obj":"CL:0000740"},{"id":"T34341","span":{"begin":3227,"end":3233},"obj":"PR:000013042"},{"id":"T34342","span":{"begin":3241,"end":3245},"obj":"CL:0000604"},{"id":"T34343","span":{"begin":3250,"end":3255},"obj":"CL:0000573"},{"id":"T34344","span":{"begin":3257,"end":3260},"obj":"PR:000014434"},{"id":"T34345","span":{"begin":3262,"end":3265},"obj":"CL:0000604"},{"id":"T34346","span":{"begin":3262,"end":3274},"obj":"PR:000014434"},{"id":"T34347","span":{"begin":3289,"end":3306},"obj":"CL:0000751"},{"id":"T34348","span":{"begin":3308,"end":3313},"obj":"PR:000003058"},{"id":"T34349","span":{"begin":3326,"end":3331},"obj":"PR:000004937"},{"id":"T34350","span":{"begin":3383,"end":3389},"obj":"PR:000013042"},{"id":"T34351","span":{"begin":3391,"end":3399},"obj":"UBERON:0000045"},{"id":"T34352","span":{"begin":3391,"end":3405},"obj":"CL:0000740"},{"id":"T34353","span":{"begin":3429,"end":3434},"obj":"PR:000003058"},{"id":"T34354","span":{"begin":3440,"end":3445},"obj":"PR:000004937"},{"id":"T34355","span":{"begin":3447,"end":3460},"obj":"CL:0000103"},{"id":"T34356","span":{"begin":3483,"end":3486},"obj":"UBERON:0001789"},{"id":"T34357","span":{"begin":3519,"end":3523},"obj":"CL:0000604"},{"id":"T34358","span":{"begin":3576,"end":3583},"obj":"NCBITaxon:33208"},{"id":"T34359","span":{"begin":3641,"end":3648},"obj":"UBERON:0000966"},{"id":"T34360","span":{"begin":3850,"end":3862},"obj":"GO:1990603"},{"id":"T34361","span":{"begin":3864,"end":3872},"obj":"GO:1990603"},{"id":"T34362","span":{"begin":4084,"end":4098},"obj":"CL:0000210"},{"id":"T34363","span":{"begin":4249,"end":4257},"obj":"CL:0000103"},{"id":"T6654","span":{"begin":1965,"end":1971},"obj":"SO:0001023"},{"id":"T6634","span":{"begin":1186,"end":1194},"obj":"UBERON:0000045"},{"id":"T6635","span":{"begin":1199,"end":1207},"obj":"CL:0000561"},{"id":"T6636","span":{"begin":1263,"end":1269},"obj":"UBERON:0000966"},{"id":"T6637","span":{"begin":1277,"end":1281},"obj":"CHEBI:472552"},{"id":"T6638","span":{"begin":1283,"end":1296},"obj":"CL:0000210"},{"id":"T6639","span":{"begin":1367,"end":1369},"obj":"PR:000013773"},{"id":"T6640","span":{"begin":1373,"end":1380},"obj":"UBERON:0000966"},{"id":"T6641","span":{"begin":1461,"end":1467},"obj":"UBERON:0000966"},{"id":"T6642","span":{"begin":1529,"end":1536},"obj":"GO:0051320"},{"id":"T6643","span":{"begin":1641,"end":1643},"obj":"PR:000013773"},{"id":"T6644","span":{"begin":1644,"end":1648},"obj":"PR:000006852"},{"id":"T6645","span":{"begin":1653,"end":1659},"obj":"UBERON:0000966"},{"id":"T6646","span":{"begin":1720,"end":1724},"obj":"PR:000006853"},{"id":"T6647","span":{"begin":1728,"end":1732},"obj":"PR:000006854"},{"id":"T6648","span":{"begin":1788,"end":1795},"obj":"GO:0007067"},{"id":"T6649","span":{"begin":1844,"end":1854},"obj":"GO:0042571"},{"id":"T6650","span":{"begin":1878,"end":1882},"obj":"PR:000006852"},{"id":"T6651","span":{"begin":1892,"end":1896},"obj":"PR:000006853"},{"id":"T6652","span":{"begin":1900,"end":1904},"obj":"PR:000006854"},{"id":"T6653","span":{"begin":1960,"end":1964},"obj":"PR:000006852"},{"id":"T6655","span":{"begin":2001,"end":2008},"obj":"GO:0051320"},{"id":"T6656","span":{"begin":2013,"end":2020},"obj":"GO:0007067"},{"id":"T6657","span":{"begin":2024,"end":2026},"obj":"PR:000013773"},{"id":"T6658","span":{"begin":2090,"end":2094},"obj":"PR:000006852"},{"id":"T6659","span":{"begin":2122,"end":2124},"obj":"PR:000013773"},{"id":"T6660","span":{"begin":2221,"end":2224},"obj":"UBERON:0001017"},{"id":"T6661","span":{"begin":2228,"end":2230},"obj":"PR:000013773"},{"id":"T6662","span":{"begin":2234,"end":2241},"obj":"UBERON:0000922"},{"id":"T6663","span":{"begin":2338,"end":2340},"obj":"PR:000013773"},{"id":"T6664","span":{"begin":2348,"end":2354},"obj":"UBERON:0000966"},{"id":"T6665","span":{"begin":2383,"end":2392},"obj":"GO:0006915"},{"id":"T6666","span":{"begin":2411,"end":2418},"obj":"_FRAGMENT"},{"id":"T6667","span":{"begin":2432,"end":2437},"obj":"CL:0000103"},{"id":"T6668","span":{"begin":2423,"end":2431},"obj":"UBERON:0000045"},{"id":"T6669","span":{"begin":2423,"end":2437},"obj":"CL:0000740"},{"id":"T6688","span":{"begin":4381,"end":4385},"obj":"PR:000006852"},{"id":"T6689","span":{"begin":4403,"end":4413},"obj":"GO:0010467"},{"id":"T6690","span":{"begin":4452,"end":4457},"obj":"SO:0000704"},{"id":"T6691","span":{"begin":4463,"end":4471},"obj":"GO:0065007"},{"id":"T6692","span":{"begin":4476,"end":4486},"obj":"GO:0007049"},{"id":"T6693","span":{"begin":4491,"end":4500},"obj":"GO:0006915"},{"id":"T6694","span":{"begin":4533,"end":4543},"obj":"GO:0007049"},{"id":"T6695","span":{"begin":4594,"end":4596},"obj":"PR:000013773"},{"id":"T6696","span":{"begin":4600,"end":4606},"obj":"UBERON:0000966"},{"id":"T6697","span":{"begin":4642,"end":4646},"obj":"PR:000006852"},{"id":"T6698","span":{"begin":4648,"end":4652},"obj":"PR:000006853"},{"id":"T6699","span":{"begin":4654,"end":4659},"obj":"PR:000028775"},{"id":"T6700","span":{"begin":4665,"end":4669},"obj":"PR:000006858"},{"id":"T6701","span":{"begin":4693,"end":4695},"obj":"PR:000013773"},{"id":"T6702","span":{"begin":4713,"end":4717},"obj":"PR:000006855"},{"id":"T6703","span":{"begin":4723,"end":4727},"obj":"PR:000006856"},{"id":"T6704","span":{"begin":4765,"end":4769},"obj":"CHEBI:472552"},{"id":"T6705","span":{"begin":4825,"end":4829},"obj":"PR:000006852"},{"id":"T6706","span":{"begin":4894,"end":4898},"obj":"PR:000006854"}],"relations":[{"id":"R1513","pred":"_lexicallyChainedTo","subj":"T6667","obj":"T6666"},{"id":"R1514","pred":"_lexicallyChainedTo","subj":"T6675","obj":"T6674"},{"id":"R1515","pred":"_lexicallyChainedTo","subj":"T6677","obj":"T6676"},{"id":"R10312","pred":"_lexicallyChainedTo","subj":"T34329","obj":"T34328"},{"id":"R10313","pred":"_lexicallyChainedTo","subj":"T34331","obj":"T34330"}],"text":"Rb Regulates Division and Death through E2f1\nWe used the α-Cre transgene to delete floxed Rb exon 19 at embryonic day (E) 10 in peripheral retina [2]. RbloxP/loxP;α-Cre mice were bred with strains lacking E2f1 or E2f2 in the germ line, or a strain carrying a floxed E2f3 allele [5]. RbloxP/loxP;E2f1+/− and RbloxP/loxP;E2f1+/−;α-Cre mice were bred to produce RbloxP/loxP;E2f1−/−;α-Cre mice at a frequency of 1/8 and littermate controls at the same or higher (1/4) frequency. For simplicity we will refer to the RbloxP/loxP;E2f1−/−;α-Cre peripheral retina as the Rb/E2f1 double knockout (DKO) retina. Similar strategies were employed in the case of E2f2 or E2f3. Cre-mediated excision of Rb and E2f3 alleles in the retina was confirmed by PCR as described previously [2,5].\nTo measure ectopic cell division, mice were pulse-labelled with bromodeoxyuridine (BrdU) 2 h before sacrifice and the peripheral retina analyzed for BrdU incorporation by immunofluorescence. As reported before [2,3], Rb KO retinas exhibited both spatial and temporal ectopic DNA synthesis (Figures 1C and S1A). This is easily detected at E14, E16, and postnatal day (P) 0 in the inner retina where abnormal BrdU+ ganglion and amacrine RTCs are located, or on the outermost region of the P0 retina, where BrdU+ photoreceptor RTCs reside (Figures S1A and S2, arrows) [2]. Ectopic RTC division in Rb KO retinas is even more obvious at P8 or P18, when division is completed in wild-type (WT) retina (Figures 1C and S1A). Strikingly, the ectopically positioned S-phase cells at E14, E16, and P0 and all the abnormal division at P8 and P18 were completely suppressed in the Rb/E2f1 DKO retina (Figures 1C, 1E, 1F, S1A, and S2). In contrast, deletion of E2f2 or E2f3 had no effect at any stage of development. Analysis of mitotic cells with anti–phosphohistone 3 (PH3)–specific antibodies confirmed that loss of E2f1, but not E2f2 or E2f3, suppressed ectopic division (Figure S3). Deleting one E2f1 allele partially suppressed ectopic S-phase and mitosis in Rb KO RTCs (Figures 1C, 1E, 1F, S1A, S2, and S3), suggesting that E2f1 drives ectopic division in Rb KO RTCs in a dose-dependent fashion. These data contrast with previous findings in the lens and CNS of Rb KO embryos, where deletion of any activating E2f suppresses ectopic division to some extent [6–9].\nLoss of Rb in the retina results in considerable RTC apoptosis, eliminating most bipolar and ganglion cells as well as many rods (Figure 2A–2D) [2,3]. The loss of Rb KO rods is evident from the thinner ONL, and the death of these cells as well as bipolar and ganglion neurons can be detected directly by double labelling for apoptotic and cell-type-specific markers [2] (M. P. and R. B., unpublished data). Loss of peripheral Rb KO ganglion cells is also evident from thinning of the optic nerve (D. C. and R. B., unpublished data). Deleting E2f1, but not E2f2 or E2f3, blocked this ectopic cell death in a dose-dependent fashion (Figures 1D, 1G, and S1B).\nFigure 2 E2f1 Deletion Rescues Ganglion, Rod, and Bipolar Cells in the Rb KO Retina\n(A) Horizontal retinal sections from mice of the indicated ages and genotypes were stained for nuclei (DAPI, blue) and markers that detect ganglion cells (Pou4f2, red), rods and cones (Sag [rod arrestin], green), and rod bipolar cells (Prkca, green, and Cabp5, red). Scale bars are 50 μm.\n(B) Quantification of Pou4f2+ ganglion cells.\n(C) Quantification of Prkca+ and Cabp5+ bipolar cells.\n(D) Thickness of the ONL, which represents the number of rods.\nError bars represent SD of measurements from three animals, and asterisks indicate a significant difference between retinas of WT and the indicated genotypes, unless indicated otherwise by connecting lines (*, p \u003c 0.05; **; p \u003c 0.01; ANOVA and Tukey HSD test).\n(E and F) ERGs were recorded from the indicated genotypes under dark-adapted (scotopic) conditions, and (E) intensity series and (F) b-wave amplitudes as a function of the logarithm of the flash intensity were determined. (F) Further illustrates that the relative influence of the mutations on the photoreceptors (indicated by the saturated a-wave amplitude, right graph) was not substantially different from their effect on the b-wave response (dominated by the bipolars, left graph) at the same intensity of 10 cd·s/m2. To investigate the molecular mechanism that underlies the unique role of E2f1, we assessed the expression of known E2f targets as well as other genes that regulate the cell cycle and apoptosis. Numerous positive and negative cell cycle and apoptotic regulators were up-regulated in the Rb KO retina (Figure 1H). Among the E2f family, E2f1, E2f2, E2f3a, and E2f7 were induced following Rb loss, but E2f3b, E2f4, and E2f5 were unaffected. Consistent with the BrdU and terminal dUTP nick-end labelling (TUNEL) analyses, E2f1 deletion specifically reversed all these molecular defects, but E2f3 deletion had no effect (Figure 1H)."}

{"project":"2_test","denotations":[{"id":"17608565-15193257-84868967","span":{"begin":147,"end":148},"obj":"15193257"},{"id":"17608565-11719808-84868968","span":{"begin":279,"end":280},"obj":"11719808"},{"id":"17608565-15193257-84868969","span":{"begin":767,"end":768},"obj":"15193257"},{"id":"17608565-11719808-84868970","span":{"begin":769,"end":770},"obj":"11719808"},{"id":"17608565-15193257-84868971","span":{"begin":984,"end":985},"obj":"15193257"},{"id":"17608565-15231717-84868972","span":{"begin":986,"end":987},"obj":"15231717"},{"id":"17608565-15193257-84868973","span":{"begin":1339,"end":1340},"obj":"15193257"},{"id":"17608565-9774968-84868974","span":{"begin":2324,"end":2325},"obj":"9774968"},{"id":"17608565-11146559-84868974","span":{"begin":2324,"end":2325},"obj":"11146559"},{"id":"17608565-11230146-84868974","span":{"begin":2324,"end":2325},"obj":"11230146"},{"id":"17608565-12065245-84868974","span":{"begin":2324,"end":2325},"obj":"12065245"},{"id":"17608565-15193257-84868975","span":{"begin":2475,"end":2476},"obj":"15193257"},{"id":"17608565-15231717-84868976","span":{"begin":2477,"end":2478},"obj":"15231717"},{"id":"17608565-15193257-84868977","span":{"begin":2697,"end":2698},"obj":"15193257"},{"id":"T96361","span":{"begin":147,"end":148},"obj":"15193257"},{"id":"T68826","span":{"begin":279,"end":280},"obj":"11719808"},{"id":"T63715","span":{"begin":767,"end":768},"obj":"15193257"},{"id":"T65532","span":{"begin":769,"end":770},"obj":"11719808"},{"id":"T7044","span":{"begin":984,"end":985},"obj":"15193257"},{"id":"T88570","span":{"begin":986,"end":987},"obj":"15231717"},{"id":"T61973","span":{"begin":1339,"end":1340},"obj":"15193257"},{"id":"T60221","span":{"begin":2324,"end":2325},"obj":"9774968"},{"id":"T11659","span":{"begin":2324,"end":2325},"obj":"11146559"},{"id":"T49571","span":{"begin":2324,"end":2325},"obj":"11230146"},{"id":"T50861","span":{"begin":2324,"end":2325},"obj":"12065245"},{"id":"T2822","span":{"begin":2475,"end":2476},"obj":"15193257"},{"id":"T607","span":{"begin":2477,"end":2478},"obj":"15231717"},{"id":"T62078","span":{"begin":2697,"end":2698},"obj":"15193257"}],"text":"Rb Regulates Division and Death through E2f1\nWe used the α-Cre transgene to delete floxed Rb exon 19 at embryonic day (E) 10 in peripheral retina [2]. RbloxP/loxP;α-Cre mice were bred with strains lacking E2f1 or E2f2 in the germ line, or a strain carrying a floxed E2f3 allele [5]. RbloxP/loxP;E2f1+/− and RbloxP/loxP;E2f1+/−;α-Cre mice were bred to produce RbloxP/loxP;E2f1−/−;α-Cre mice at a frequency of 1/8 and littermate controls at the same or higher (1/4) frequency. For simplicity we will refer to the RbloxP/loxP;E2f1−/−;α-Cre peripheral retina as the Rb/E2f1 double knockout (DKO) retina. Similar strategies were employed in the case of E2f2 or E2f3. Cre-mediated excision of Rb and E2f3 alleles in the retina was confirmed by PCR as described previously [2,5].\nTo measure ectopic cell division, mice were pulse-labelled with bromodeoxyuridine (BrdU) 2 h before sacrifice and the peripheral retina analyzed for BrdU incorporation by immunofluorescence. As reported before [2,3], Rb KO retinas exhibited both spatial and temporal ectopic DNA synthesis (Figures 1C and S1A). This is easily detected at E14, E16, and postnatal day (P) 0 in the inner retina where abnormal BrdU+ ganglion and amacrine RTCs are located, or on the outermost region of the P0 retina, where BrdU+ photoreceptor RTCs reside (Figures S1A and S2, arrows) [2]. Ectopic RTC division in Rb KO retinas is even more obvious at P8 or P18, when division is completed in wild-type (WT) retina (Figures 1C and S1A). Strikingly, the ectopically positioned S-phase cells at E14, E16, and P0 and all the abnormal division at P8 and P18 were completely suppressed in the Rb/E2f1 DKO retina (Figures 1C, 1E, 1F, S1A, and S2). In contrast, deletion of E2f2 or E2f3 had no effect at any stage of development. Analysis of mitotic cells with anti–phosphohistone 3 (PH3)–specific antibodies confirmed that loss of E2f1, but not E2f2 or E2f3, suppressed ectopic division (Figure S3). Deleting one E2f1 allele partially suppressed ectopic S-phase and mitosis in Rb KO RTCs (Figures 1C, 1E, 1F, S1A, S2, and S3), suggesting that E2f1 drives ectopic division in Rb KO RTCs in a dose-dependent fashion. These data contrast with previous findings in the lens and CNS of Rb KO embryos, where deletion of any activating E2f suppresses ectopic division to some extent [6–9].\nLoss of Rb in the retina results in considerable RTC apoptosis, eliminating most bipolar and ganglion cells as well as many rods (Figure 2A–2D) [2,3]. The loss of Rb KO rods is evident from the thinner ONL, and the death of these cells as well as bipolar and ganglion neurons can be detected directly by double labelling for apoptotic and cell-type-specific markers [2] (M. P. and R. B., unpublished data). Loss of peripheral Rb KO ganglion cells is also evident from thinning of the optic nerve (D. C. and R. B., unpublished data). Deleting E2f1, but not E2f2 or E2f3, blocked this ectopic cell death in a dose-dependent fashion (Figures 1D, 1G, and S1B).\nFigure 2 E2f1 Deletion Rescues Ganglion, Rod, and Bipolar Cells in the Rb KO Retina\n(A) Horizontal retinal sections from mice of the indicated ages and genotypes were stained for nuclei (DAPI, blue) and markers that detect ganglion cells (Pou4f2, red), rods and cones (Sag [rod arrestin], green), and rod bipolar cells (Prkca, green, and Cabp5, red). Scale bars are 50 μm.\n(B) Quantification of Pou4f2+ ganglion cells.\n(C) Quantification of Prkca+ and Cabp5+ bipolar cells.\n(D) Thickness of the ONL, which represents the number of rods.\nError bars represent SD of measurements from three animals, and asterisks indicate a significant difference between retinas of WT and the indicated genotypes, unless indicated otherwise by connecting lines (*, p \u003c 0.05; **; p \u003c 0.01; ANOVA and Tukey HSD test).\n(E and F) ERGs were recorded from the indicated genotypes under dark-adapted (scotopic) conditions, and (E) intensity series and (F) b-wave amplitudes as a function of the logarithm of the flash intensity were determined. (F) Further illustrates that the relative influence of the mutations on the photoreceptors (indicated by the saturated a-wave amplitude, right graph) was not substantially different from their effect on the b-wave response (dominated by the bipolars, left graph) at the same intensity of 10 cd·s/m2. To investigate the molecular mechanism that underlies the unique role of E2f1, we assessed the expression of known E2f targets as well as other genes that regulate the cell cycle and apoptosis. Numerous positive and negative cell cycle and apoptotic regulators were up-regulated in the Rb KO retina (Figure 1H). Among the E2f family, E2f1, E2f2, E2f3a, and E2f7 were induced following Rb loss, but E2f3b, E2f4, and E2f5 were unaffected. Consistent with the BrdU and terminal dUTP nick-end labelling (TUNEL) analyses, E2f1 deletion specifically reversed all these molecular defects, but E2f3 deletion had no effect (Figure 1H)."}