PMC:1914394 / 11631-16565 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T6888	0-2	NN	denotes	Rb
T6889	3-12	VBZ	denotes	Regulates
T6890	13-21	NN	denotes	Division
T6891	22-25	CC	denotes	and
T6892	26-31	NN	denotes	Death
T6893	32-39	IN	denotes	through
T6894	40-44	NN	denotes	E2f1
T6895	44-150	sentence	denotes	We used the α-Cre transgene to delete floxed Rb exon 19 at embryonic day (E) 10 in peripheral retina [2].
T6896	45-47	PRP	denotes	We
T6897	48-52	VBD	denotes	used
T6898	53-56	DT	denotes	the
T6899	63-72	NN	denotes	transgene
T6900	57-58	NN	denotes	α
T6901	59-62	NN	denotes	Cre
T6902	58-59	HYPH	denotes	-
T6903	73-75	TO	denotes	to
T6904	76-82	VB	denotes	delete
T6905	83-89	VBN	denotes	floxed
T6906	93-97	NN	denotes	exon
T6907	90-92	NN	denotes	Rb
T6908	98-100	CD	denotes	19
T6909	101-103	IN	denotes	at
T6910	104-113	JJ	denotes	embryonic
T6911	114-117	NN	denotes	day
T6912	118-119	-LRB-	denotes	(
T6913	119-120	NN	denotes	E
T6914	120-121	-RRB-	denotes	)
T6915	122-124	CD	denotes	10
T6916	125-127	IN	denotes	in
T6917	128-138	JJ	denotes	peripheral
T6918	139-145	NN	denotes	retina
T6919	146-147	-LRB-	denotes	[
T6920	147-148	CD	denotes	2
T6921	148-149	-RRB-	denotes	]
T6922	149-150	.	denotes	.
T6923	150-282	sentence	denotes	RbloxP/loxP;α-Cre mice were bred with strains lacking E2f1 or E2f2 in the germ line, or a strain carrying a floxed E2f3 allele [5].
T6924	151-157	NN	denotes	RbloxP
T6925	158-162	NN	denotes	loxP
T6926	157-158	HYPH	denotes	/
T6927	169-173	NNS	denotes	mice
T6928	162-163	:	denotes	;
T6929	163-164	NN	denotes	α
T6930	165-168	NN	denotes	Cre
T6931	164-165	HYPH	denotes	-
T6932	179-183	VBN	denotes	bred
T6933	174-178	VBD	denotes	were
T6934	184-188	IN	denotes	with
T6935	189-196	NNS	denotes	strains
T6936	197-204	VBG	denotes	lacking
T6937	205-209	NN	denotes	E2f1
T6938	210-212	CC	denotes	or
T6939	213-217	NN	denotes	E2f2
T6940	218-220	IN	denotes	in
T6941	221-224	DT	denotes	the
T6942	230-234	NN	denotes	line
T6943	225-229	NN	denotes	germ
T6944	234-236	,	denotes	,
T6945	236-238	CC	denotes	or
T6946	239-240	DT	denotes	a
T6947	241-247	NN	denotes	strain
T6948	248-256	VBG	denotes	carrying
T6949	257-258	DT	denotes	a
T6950	271-277	NN	denotes	allele
T6951	259-265	VBN	denotes	floxed
T6952	266-270	NN	denotes	E2f3
T6953	278-279	-LRB-	denotes	[
T6954	279-280	CD	denotes	5
T6955	280-281	-RRB-	denotes	]
T6956	281-282	.	denotes	.
T6957	282-474	sentence	denotes	RbloxP/loxP;E2f1+/− and RbloxP/loxP;E2f1+/−;α-Cre mice were bred to produce RbloxP/loxP;E2f1−/−;α-Cre mice at a frequency of 1/8 and littermate controls at the same or higher (1/4) frequency.
T6958	283-289	NN	denotes	RbloxP
T6959	290-294	NN	denotes	loxP
T6960	289-290	HYPH	denotes	/
T6961	333-337	NNS	denotes	mice
T6962	294-295	:	denotes	;
T6963	295-299	NN	denotes	E2f1
T6964	299-300	SYM	denotes	+
T6965	300-301	HYPH	denotes	/
T6966	301-302	SYM	denotes	−
T6967	303-306	CC	denotes	and
T6968	307-313	NN	denotes	RbloxP
T6969	314-318	NN	denotes	loxP
T6970	313-314	HYPH	denotes	/
T6971	318-319	:	denotes	;
T6972	319-323	NN	denotes	E2f1
T6973	323-324	SYM	denotes	+
T6974	324-325	HYPH	denotes	/
T6975	325-326	SYM	denotes	−
T6976	326-327	:	denotes	;
T6977	327-328	NN	denotes	α
T6978	329-332	NN	denotes	Cre
T6979	328-329	HYPH	denotes	-
T6980	343-347	VBN	denotes	bred
T6981	338-342	VBD	denotes	were
T6982	348-350	TO	denotes	to
T6983	351-358	VB	denotes	produce
T6984	359-365	NN	denotes	RbloxP
T6985	366-370	NN	denotes	loxP
T6986	365-366	HYPH	denotes	/
T6987	385-389	NNS	denotes	mice
T6988	370-371	:	denotes	;
T6989	371-375	NN	denotes	E2f1
T6990	375-376	SYM	denotes	−
T6991	376-377	HYPH	denotes	/
T6992	377-378	SYM	denotes	−
T6993	378-379	:	denotes	;
T6994	379-380	NN	denotes	α
T6995	381-384	NN	denotes	Cre
T6996	380-381	HYPH	denotes	-
T6997	390-392	IN	denotes	at
T6998	393-394	DT	denotes	a
T6999	395-404	NN	denotes	frequency
T7000	405-407	IN	denotes	of
T7001	408-409	CD	denotes	1
T7002	410-411	CD	denotes	8
T7003	409-410	SYM	denotes	/
T7004	412-415	CC	denotes	and
T7005	416-426	NN	denotes	littermate
T7006	427-435	NNS	denotes	controls
T7007	436-438	IN	denotes	at
T7008	439-442	DT	denotes	the
T7009	443-447	JJ	denotes	same
T7010	448-450	CC	denotes	or
T7011	451-457	JJR	denotes	higher
T7012	464-473	NN	denotes	frequency
T7013	458-459	-LRB-	denotes	(
T7014	459-460	CD	denotes	1
T7015	460-461	SYM	denotes	/
T7016	461-462	CD	denotes	4
T7017	462-463	-RRB-	denotes	)
T7018	473-474	.	denotes	.
T7019	474-599	sentence	denotes	For simplicity we will refer to the RbloxP/loxP;E2f1−/−;α-Cre peripheral retina as the Rb/E2f1 double knockout (DKO) retina.
T7020	475-478	IN	denotes	For
T7021	498-503	VB	denotes	refer
T7022	479-489	NN	denotes	simplicity
T7023	490-492	PRP	denotes	we
T7024	493-497	MD	denotes	will
T7025	504-506	IN	denotes	to
T7026	507-510	DT	denotes	the
T7027	548-554	NN	denotes	retina
T7028	511-517	NN	denotes	RbloxP
T7029	518-522	NN	denotes	loxP
T7030	517-518	HYPH	denotes	/
T7031	522-523	:	denotes	;
T7032	523-527	NN	denotes	E2f1
T7033	527-528	SYM	denotes	−
T7034	528-529	HYPH	denotes	/
T7035	529-530	SYM	denotes	−
T7036	530-531	:	denotes	;
T7037	531-532	NN	denotes	α
T7038	533-536	NN	denotes	Cre
T7039	532-533	HYPH	denotes	-
T7040	537-547	JJ	denotes	peripheral
T7041	555-557	IN	denotes	as
T7042	558-561	DT	denotes	the
T7043	592-598	NN	denotes	retina
T7044	562-564	NN	denotes	Rb
T7045	565-569	NN	denotes	E2f1
T7046	564-565	HYPH	denotes	/
T7047	570-576	JJ	denotes	double
T7048	577-585	NN	denotes	knockout
T7049	586-587	-LRB-	denotes	(
T7050	587-590	NN	denotes	DKO
T7051	590-591	-RRB-	denotes	)
T7052	598-599	.	denotes	.
T7053	599-661	sentence	denotes	Similar strategies were employed in the case of E2f2 or E2f3.
T7054	600-607	JJ	denotes	Similar
T7055	608-618	NNS	denotes	strategies
T7056	624-632	VBN	denotes	employed
T7057	619-623	VBD	denotes	were
T7058	633-635	IN	denotes	in
T7059	636-639	DT	denotes	the
T7060	640-644	NN	denotes	case
T7061	645-647	IN	denotes	of
T7062	648-652	NN	denotes	E2f2
T7063	653-655	CC	denotes	or
T7064	656-660	NN	denotes	E2f3
T7065	660-661	.	denotes	.
T7066	661-772	sentence	denotes	Cre-mediated excision of Rb and E2f3 alleles in the retina was confirmed by PCR as described previously [2,5].
T7067	662-665	NN	denotes	Cre
T7068	666-674	VBN	denotes	mediated
T7069	665-666	HYPH	denotes	-
T7070	675-683	NN	denotes	excision
T7071	725-734	VBN	denotes	confirmed
T7072	684-686	IN	denotes	of
T7073	687-689	NN	denotes	Rb
T7074	699-706	NNS	denotes	alleles
T7075	690-693	CC	denotes	and
T7076	694-698	NN	denotes	E2f3
T7077	707-709	IN	denotes	in
T7078	710-713	DT	denotes	the
T7079	714-720	NN	denotes	retina
T7080	721-724	VBD	denotes	was
T7081	735-737	IN	denotes	by
T7082	738-741	NN	denotes	PCR
T7083	742-744	IN	denotes	as
T7084	745-754	VBN	denotes	described
T7085	755-765	RB	denotes	previously
T7086	766-767	-LRB-	denotes	[
T7087	769-770	CD	denotes	5
T7088	767-768	CD	denotes	2
T7089	768-769	,	denotes	,
T7090	770-771	-RRB-	denotes	]
T7091	771-772	.	denotes	.
T7092	772-963	sentence	denotes	To measure ectopic cell division, mice were pulse-labelled with bromodeoxyuridine (BrdU) 2 h before sacrifice and the peripheral retina analyzed for BrdU incorporation by immunofluorescence.
T7093	773-775	TO	denotes	To
T7094	776-783	VB	denotes	measure
T7095	823-831	VBN	denotes	labelled
T7096	784-791	JJ	denotes	ectopic
T7097	797-805	NN	denotes	division
T7098	792-796	NN	denotes	cell
T7099	805-807	,	denotes	,
T7100	807-811	NNS	denotes	mice
T7101	812-816	VBD	denotes	were
T7102	817-822	NN	denotes	pulse
T7103	822-823	HYPH	denotes	-
T7104	832-836	IN	denotes	with
T7105	837-854	NN	denotes	bromodeoxyuridine
T7106	855-856	-LRB-	denotes	(
T7107	856-860	NN	denotes	BrdU
T7108	860-861	-RRB-	denotes	)
T7109	862-863	CD	denotes	2
T7110	864-865	NN	denotes	h
T7111	866-872	IN	denotes	before
T7112	873-882	NN	denotes	sacrifice
T7113	883-886	CC	denotes	and
T7114	887-890	DT	denotes	the
T7115	902-908	NN	denotes	retina
T7116	891-901	JJ	denotes	peripheral
T7117	909-917	VBN	denotes	analyzed
T7118	918-921	IN	denotes	for
T7119	922-926	NN	denotes	BrdU
T7120	927-940	NN	denotes	incorporation
T7121	941-943	IN	denotes	by
T7122	944-962	NN	denotes	immunofluorescence
T7123	962-963	.	denotes	.
T7124	963-1083	sentence	denotes	As reported before [2,3], Rb KO retinas exhibited both spatial and temporal ectopic DNA synthesis (Figures 1C and S1A).
T7125	964-966	IN	denotes	As
T7126	967-975	VBN	denotes	reported
T7127	1004-1013	VBD	denotes	exhibited
T7128	976-982	RB	denotes	before
T7129	983-984	-LRB-	denotes	[
T7130	986-987	CD	denotes	3
T7131	984-985	CD	denotes	2
T7132	985-986	,	denotes	,
T7133	987-988	-RRB-	denotes	]
T7134	988-990	DT	denotes	,
T7135	990-992	NN	denotes	Rb
T7136	993-995	NN	denotes	KO
T7137	996-1003	NNS	denotes	retinas
T7138	1014-1018	CC	denotes	both
T7139	1019-1026	JJ	denotes	spatial
T7140	1052-1061	NN	denotes	synthesis
T7141	1027-1030	CC	denotes	and
T7142	1031-1039	JJ	denotes	temporal
T7143	1040-1047	JJ	denotes	ectopic
T7144	1048-1051	NN	denotes	DNA
T7145	1062-1063	-LRB-	denotes	(
T7146	1071-1073	NN	denotes	1C
T7147	1063-1070	NNS	denotes	Figures
T7148	1074-1077	CC	denotes	and
T7149	1078-1081	NN	denotes	S1A
T7150	1081-1082	-RRB-	denotes	)
T7151	1082-1083	.	denotes	.
T7152	1083-1342	sentence	denotes	This is easily detected at E14, E16, and postnatal day (P) 0 in the inner retina where abnormal BrdU+ ganglion and amacrine RTCs are located, or on the outermost region of the P0 retina, where BrdU+ photoreceptor RTCs reside (Figures S1A and S2, arrows) [2].
T7153	1084-1088	DT	denotes	This
T7154	1099-1107	VBN	denotes	detected
T7155	1089-1091	VBZ	denotes	is
T7156	1092-1098	RB	denotes	easily
T7157	1108-1110	IN	denotes	at
T7158	1111-1114	NN	denotes	E14
T7159	1114-1116	,	denotes	,
T7160	1116-1119	NN	denotes	E16
T7161	1119-1121	,	denotes	,
T7162	1121-1124	CC	denotes	and
T7163	1125-1134	JJ	denotes	postnatal
T7164	1135-1138	NN	denotes	day
T7165	1139-1140	-LRB-	denotes	(
T7166	1140-1141	NN	denotes	P
T7167	1141-1142	-RRB-	denotes	)
T7168	1143-1144	CD	denotes	0
T7169	1145-1147	IN	denotes	in
T7170	1148-1151	DT	denotes	the
T7171	1158-1164	NN	denotes	retina
T7172	1152-1157	JJ	denotes	inner
T7173	1165-1170	WRB	denotes	where
T7174	1217-1224	VBN	denotes	located
T7175	1171-1179	JJ	denotes	abnormal
T7176	1208-1212	NNS	denotes	RTCs
T7177	1180-1184	NN	denotes	BrdU
T7178	1184-1185	SYM	denotes	+
T7179	1186-1194	NN	denotes	ganglion
T7180	1195-1198	CC	denotes	and
T7181	1199-1207	JJ	denotes	amacrine
T7182	1213-1216	VBP	denotes	are
T7183	1224-1226	,	denotes	,
T7184	1226-1228	CC	denotes	or
T7185	1229-1231	IN	denotes	on
T7186	1232-1235	DT	denotes	the
T7187	1246-1252	NN	denotes	region
T7188	1236-1245	JJ	denotes	outermost
T7189	1253-1255	IN	denotes	of
T7190	1256-1259	DT	denotes	the
T7191	1263-1269	NN	denotes	retina
T7192	1260-1262	NN	denotes	P0
T7193	1269-1271	,	denotes	,
T7194	1271-1276	WRB	denotes	where
T7195	1302-1308	VBP	denotes	reside
T7196	1277-1281	NN	denotes	BrdU
T7197	1297-1301	NNS	denotes	RTCs
T7198	1281-1282	SYM	denotes	+
T7199	1283-1296	NN	denotes	photoreceptor
T7200	1309-1310	-LRB-	denotes	(
T7201	1330-1336	NNS	denotes	arrows
T7202	1310-1317	NNS	denotes	Figures
T7203	1318-1321	NN	denotes	S1A
T7204	1322-1325	CC	denotes	and
T7205	1326-1328	NN	denotes	S2
T7206	1328-1330	,	denotes	,
T7207	1336-1337	-RRB-	denotes	)
T7208	1338-1339	-LRB-	denotes	[
T7209	1339-1340	CD	denotes	2
T7210	1340-1341	-RRB-	denotes	]
T7211	1341-1342	.	denotes	.
T7212	1342-1489	sentence	denotes	Ectopic RTC division in Rb KO retinas is even more obvious at P8 or P18, when division is completed in wild-type (WT) retina (Figures 1C and S1A).
T7213	1343-1350	JJ	denotes	Ectopic
T7214	1355-1363	NN	denotes	division
T7215	1351-1354	NN	denotes	RTC
T7216	1381-1383	VBZ	denotes	is
T7217	1364-1366	IN	denotes	in
T7218	1367-1369	NN	denotes	Rb
T7219	1370-1372	NN	denotes	KO
T7220	1373-1380	NNS	denotes	retinas
T7221	1384-1388	RB	denotes	even
T7222	1389-1393	RBR	denotes	more
T7223	1394-1401	JJ	denotes	obvious
T7224	1402-1404	IN	denotes	at
T7225	1405-1407	NN	denotes	P8
T7226	1408-1410	CC	denotes	or
T7227	1411-1414	NN	denotes	P18
T7228	1414-1416	,	denotes	,
T7229	1416-1420	WRB	denotes	when
T7230	1433-1442	VBN	denotes	completed
T7231	1421-1429	NN	denotes	division
T7232	1430-1432	VBZ	denotes	is
T7233	1443-1445	IN	denotes	in
T7234	1446-1450	JJ	denotes	wild
T7235	1451-1455	NN	denotes	type
T7236	1450-1451	HYPH	denotes	-
T7237	1461-1467	NN	denotes	retina
T7238	1456-1457	-LRB-	denotes	(
T7239	1457-1459	NN	denotes	WT
T7240	1459-1460	-RRB-	denotes	)
T7241	1468-1469	-LRB-	denotes	(
T7242	1477-1479	NN	denotes	1C
T7243	1469-1476	NNS	denotes	Figures
T7244	1480-1483	CC	denotes	and
T7245	1484-1487	NN	denotes	S1A
T7246	1487-1488	-RRB-	denotes	)
T7247	1488-1489	.	denotes	.
T7248	1489-1694	sentence	denotes	Strikingly, the ectopically positioned S-phase cells at E14, E16, and P0 and all the abnormal division at P8 and P18 were completely suppressed in the Rb/E2f1 DKO retina (Figures 1C, 1E, 1F, S1A, and S2).
T7249	1490-1500	RB	denotes	Strikingly
T7250	1623-1633	VBN	denotes	suppressed
T7251	1500-1502	,	denotes	,
T7252	1502-1505	DT	denotes	the
T7253	1537-1542	NNS	denotes	cells
T7254	1506-1517	RB	denotes	ectopically
T7255	1518-1528	VBN	denotes	positioned
T7256	1529-1530	NN	denotes	S
T7257	1531-1536	NN	denotes	phase
T7258	1530-1531	HYPH	denotes	-
T7259	1543-1545	IN	denotes	at
T7260	1546-1549	NN	denotes	E14
T7261	1549-1551	,	denotes	,
T7262	1551-1554	NN	denotes	E16
T7263	1554-1556	,	denotes	,
T7264	1556-1559	CC	denotes	and
T7265	1560-1562	NN	denotes	P0
T7266	1563-1566	CC	denotes	and
T7267	1567-1570	PDT	denotes	all
T7268	1584-1592	NN	denotes	division
T7269	1571-1574	DT	denotes	the
T7270	1575-1583	JJ	denotes	abnormal
T7271	1593-1595	IN	denotes	at
T7272	1596-1598	NN	denotes	P8
T7273	1599-1602	CC	denotes	and
T7274	1603-1606	NN	denotes	P18
T7275	1607-1611	VBD	denotes	were
T7276	1612-1622	RB	denotes	completely
T7277	1634-1636	IN	denotes	in
T7278	1637-1640	DT	denotes	the
T7279	1653-1659	NN	denotes	retina
T7280	1641-1643	NN	denotes	Rb
T7281	1644-1648	NN	denotes	E2f1
T7282	1643-1644	HYPH	denotes	/
T7283	1649-1652	NN	denotes	DKO
T7284	1660-1661	-LRB-	denotes	(
T7285	1669-1671	NN	denotes	1C
T7286	1661-1668	NNS	denotes	Figures
T7287	1671-1673	,	denotes	,
T7288	1673-1675	NN	denotes	1E
T7289	1675-1677	,	denotes	,
T7290	1677-1679	NN	denotes	1F
T7291	1679-1681	,	denotes	,
T7292	1681-1684	NN	denotes	S1A
T7293	1684-1686	,	denotes	,
T7294	1686-1689	CC	denotes	and
T7295	1690-1692	NN	denotes	S2
T7296	1692-1693	-RRB-	denotes	)
T7297	1693-1694	.	denotes	.
T7298	1694-1775	sentence	denotes	In contrast, deletion of E2f2 or E2f3 had no effect at any stage of development.
T7299	1695-1697	IN	denotes	In
T7300	1733-1736	VBD	denotes	had
T7301	1698-1706	NN	denotes	contrast
T7302	1706-1708	,	denotes	,
T7303	1708-1716	NN	denotes	deletion
T7304	1717-1719	IN	denotes	of
T7305	1720-1724	NN	denotes	E2f2
T7306	1725-1727	CC	denotes	or
T7307	1728-1732	NN	denotes	E2f3
T7308	1737-1739	DT	denotes	no
T7309	1740-1746	NN	denotes	effect
T7310	1747-1749	IN	denotes	at
T7311	1750-1753	DT	denotes	any
T7312	1754-1759	NN	denotes	stage
T7313	1760-1762	IN	denotes	of
T7314	1763-1774	NN	denotes	development
T7315	1774-1775	.	denotes	.
T7316	1775-1946	sentence	denotes	Analysis of mitotic cells with anti–phosphohistone 3 (PH3)–specific antibodies confirmed that loss of E2f1, but not E2f2 or E2f3, suppressed ectopic division (Figure S3).
T7317	1776-1784	NN	denotes	Analysis
T7318	1855-1864	VBD	denotes	confirmed
T7319	1785-1787	IN	denotes	of
T7320	1788-1795	JJ	denotes	mitotic
T7321	1796-1801	NNS	denotes	cells
T7322	1802-1806	IN	denotes	with
T7323	1807-1826	NN	denotes	anti–phosphohistone
T7324	1835-1843	JJ	denotes	specific
T7325	1827-1828	CD	denotes	3
T7326	1829-1830	-LRB-	denotes	(
T7327	1830-1833	NN	denotes	PH3
T7328	1833-1834	-RRB-	denotes	)
T7329	1834-1835	HYPH	denotes	–
T7330	1844-1854	NNS	denotes	antibodies
T7331	1865-1869	IN	denotes	that
T7332	1906-1916	VBD	denotes	suppressed
T7333	1870-1874	NN	denotes	loss
T7334	1875-1877	IN	denotes	of
T7335	1878-1882	NN	denotes	E2f1
T7336	1882-1884	,	denotes	,
T7337	1884-1887	CC	denotes	but
T7338	1888-1891	RB	denotes	not
T7339	1892-1896	NN	denotes	E2f2
T7340	1897-1899	CC	denotes	or
T7341	1900-1904	NN	denotes	E2f3
T7342	1904-1906	,	denotes	,
T7343	1917-1924	JJ	denotes	ectopic
T7344	1925-1933	NN	denotes	division
T7345	1934-1935	-LRB-	denotes	(
T7346	1942-1944	NN	denotes	S3
T7347	1935-1941	NN	denotes	Figure
T7348	1944-1945	-RRB-	denotes	)
T7349	1945-1946	.	denotes	.
T7350	1946-2161	sentence	denotes	Deleting one E2f1 allele partially suppressed ectopic S-phase and mitosis in Rb KO RTCs (Figures 1C, 1E, 1F, S1A, S2, and S3), suggesting that E2f1 drives ectopic division in Rb KO RTCs in a dose-dependent fashion.
T7351	1947-1955	VBG	denotes	Deleting
T7352	1982-1992	VBD	denotes	suppressed
T7353	1956-1959	CD	denotes	one
T7354	1965-1971	NN	denotes	allele
T7355	1960-1964	NN	denotes	E2f1
T7356	1972-1981	RB	denotes	partially
T7357	1993-2000	JJ	denotes	ectopic
T7358	2003-2008	NN	denotes	phase
T7359	2001-2002	NN	denotes	S
T7360	2002-2003	HYPH	denotes	-
T7361	2009-2012	CC	denotes	and
T7362	2013-2020	NN	denotes	mitosis
T7363	2021-2023	IN	denotes	in
T7364	2024-2026	NN	denotes	Rb
T7365	2027-2029	NN	denotes	KO
T7366	2030-2034	NNS	denotes	RTCs
T7367	2035-2036	-LRB-	denotes	(
T7368	2044-2046	NN	denotes	1C
T7369	2036-2043	NNS	denotes	Figures
T7370	2046-2048	,	denotes	,
T7371	2048-2050	NN	denotes	1E
T7372	2050-2052	,	denotes	,
T7373	2052-2054	NN	denotes	1F
T7374	2054-2056	,	denotes	,
T7375	2056-2059	NN	denotes	S1A
T7376	2059-2061	,	denotes	,
T7377	2061-2063	NN	denotes	S2
T7378	2063-2065	,	denotes	,
T7379	2065-2068	CC	denotes	and
T7380	2069-2071	NN	denotes	S3
T7381	2071-2072	-RRB-	denotes	)
T7382	2072-2074	,	denotes	,
T7383	2074-2084	VBG	denotes	suggesting
T7384	2085-2089	IN	denotes	that
T7385	2095-2101	VBZ	denotes	drives
T7386	2090-2094	NN	denotes	E2f1
T7387	2102-2109	JJ	denotes	ectopic
T7388	2110-2118	NN	denotes	division
T7389	2119-2121	IN	denotes	in
T7390	2122-2124	NN	denotes	Rb
T7391	2125-2127	NN	denotes	KO
T7392	2128-2132	NNS	denotes	RTCs
T7393	2133-2135	IN	denotes	in
T7394	2136-2137	DT	denotes	a
T7395	2153-2160	NN	denotes	fashion
T7396	2138-2142	NN	denotes	dose
T7397	2143-2152	JJ	denotes	dependent
T7398	2142-2143	HYPH	denotes	-
T7399	2160-2161	.	denotes	.
T7400	2161-2329	sentence	denotes	These data contrast with previous findings in the lens and CNS of Rb KO embryos, where deletion of any activating E2f suppresses ectopic division to some extent [6–9].
T7401	2162-2167	DT	denotes	These
T7402	2168-2172	NNS	denotes	data
T7403	2173-2181	VBP	denotes	contrast
T7404	2182-2186	IN	denotes	with
T7405	2187-2195	JJ	denotes	previous
T7406	2196-2204	NNS	denotes	findings
T7407	2205-2207	IN	denotes	in
T7408	2208-2211	DT	denotes	the
T7409	2212-2216	NN	denotes	lens
T7410	2217-2220	CC	denotes	and
T7411	2221-2224	NN	denotes	CNS
T7412	2225-2227	IN	denotes	of
T7413	2228-2230	NN	denotes	Rb
T7414	2231-2233	NN	denotes	KO
T7415	2234-2241	NNS	denotes	embryos
T7416	2241-2243	,	denotes	,
T7417	2243-2248	WRB	denotes	where
T7418	2280-2290	VBZ	denotes	suppresses
T7419	2249-2257	NN	denotes	deletion
T7420	2258-2260	IN	denotes	of
T7421	2261-2264	DT	denotes	any
T7422	2276-2279	NN	denotes	E2f
T7423	2265-2275	VBG	denotes	activating
T7424	2291-2298	JJ	denotes	ectopic
T7425	2299-2307	NN	denotes	division
T7426	2308-2310	IN	denotes	to
T7427	2311-2315	DT	denotes	some
T7428	2316-2322	NN	denotes	extent
T7429	2323-2324	-LRB-	denotes	[
T7430	2324-2325	CD	denotes	6
T7431	2325-2326	SYM	denotes	–
T7432	2326-2327	CD	denotes	9
T7433	2327-2328	-RRB-	denotes	]
T7434	2328-2329	.	denotes	.
T7435	2329-2480	sentence	denotes	Loss of Rb in the retina results in considerable RTC apoptosis, eliminating most bipolar and ganglion cells as well as many rods (Figure 2A–2D) [2,3].
T7436	2330-2334	NN	denotes	Loss
T7437	2355-2362	VBZ	denotes	results
T7438	2335-2337	IN	denotes	of
T7439	2338-2340	NN	denotes	Rb
T7440	2341-2343	IN	denotes	in
T7441	2344-2347	DT	denotes	the
T7442	2348-2354	NN	denotes	retina
T7443	2363-2365	IN	denotes	in
T7444	2366-2378	JJ	denotes	considerable
T7445	2383-2392	NN	denotes	apoptosis
T7446	2379-2382	NN	denotes	RTC
T7447	2392-2394	,	denotes	,
T7448	2394-2405	VBG	denotes	eliminating
T7449	2406-2410	JJS	denotes	most
T7450	2432-2437	NNS	denotes	cells
T7451	2411-2418	JJ	denotes	bipolar
T7452	2419-2422	CC	denotes	and
T7453	2423-2431	NN	denotes	ganglion
T7454	2438-2440	RB	denotes	as
T7455	2446-2448	IN	denotes	as
T7456	2441-2445	RB	denotes	well
T7457	2449-2453	JJ	denotes	many
T7458	2454-2458	NNS	denotes	rods
T7459	2459-2460	-LRB-	denotes	(
T7460	2467-2469	NN	denotes	2A
T7461	2460-2466	NN	denotes	Figure
T7462	2469-2470	SYM	denotes	–
T7463	2470-2472	NN	denotes	2D
T7464	2472-2473	-RRB-	denotes	)
T7465	2474-2475	-LRB-	denotes	[
T7466	2477-2478	CD	denotes	3
T7467	2475-2476	CD	denotes	2
T7468	2476-2477	,	denotes	,
T7469	2478-2479	-RRB-	denotes	]
T7470	2479-2480	.	denotes	.
T7471	2480-2736	sentence	denotes	The loss of Rb KO rods is evident from the thinner ONL, and the death of these cells as well as bipolar and ganglion neurons can be detected directly by double labelling for apoptotic and cell-type-specific markers [2] (M. P. and R. B., unpublished data).
T7472	2481-2484	DT	denotes	The
T7473	2485-2489	NN	denotes	loss
T7474	2504-2506	VBZ	denotes	is
T7475	2490-2492	IN	denotes	of
T7476	2493-2495	NN	denotes	Rb
T7477	2496-2498	NN	denotes	KO
T7478	2499-2503	NNS	denotes	rods
T7479	2507-2514	JJ	denotes	evident
T7480	2515-2519	IN	denotes	from
T7481	2520-2523	DT	denotes	the
T7482	2532-2535	NN	denotes	ONL
T7483	2524-2531	JJ	denotes	thinner
T7484	2535-2537	,	denotes	,
T7485	2537-2540	CC	denotes	and
T7486	2541-2544	DT	denotes	the
T7487	2545-2550	NN	denotes	death
T7488	2613-2621	VBN	denotes	detected
T7489	2551-2553	IN	denotes	of
T7490	2554-2559	DT	denotes	these
T7491	2560-2565	NNS	denotes	cells
T7492	2566-2568	RB	denotes	as
T7493	2574-2576	IN	denotes	as
T7494	2569-2573	RB	denotes	well
T7495	2577-2584	JJ	denotes	bipolar
T7496	2598-2605	NNS	denotes	neurons
T7497	2585-2588	CC	denotes	and
T7498	2589-2597	NN	denotes	ganglion
T7499	2606-2609	MD	denotes	can
T7500	2610-2612	VB	denotes	be
T7501	2622-2630	RB	denotes	directly
T7502	2631-2633	IN	denotes	by
T7503	2634-2640	RB	denotes	double
T7504	2641-2650	VBG	denotes	labelling
T7505	2651-2654	IN	denotes	for
T7506	2655-2664	JJ	denotes	apoptotic
T7507	2688-2695	NNS	denotes	markers
T7508	2665-2668	CC	denotes	and
T7509	2669-2673	NN	denotes	cell
T7510	2674-2678	NN	denotes	type
T7511	2673-2674	HYPH	denotes	-
T7512	2679-2687	JJ	denotes	specific
T7513	2678-2679	HYPH	denotes	-
T7514	2696-2697	-LRB-	denotes	[
T7515	2697-2698	CD	denotes	2
T7516	2698-2699	-RRB-	denotes	]
T7517	2700-2701	-LRB-	denotes	(
T7518	2701-2703	NNP	denotes	M.
T7519	2704-2706	NNP	denotes	P.
T7520	2707-2710	CC	denotes	and
T7521	2711-2713	NNP	denotes	R.
T7522	2714-2716	NNP	denotes	B.
T7523	2716-2718	,	denotes	,
T7524	2718-2729	JJ	denotes	unpublished
T7525	2730-2734	NNS	denotes	data
T7526	2734-2735	-RRB-	denotes	)
T7527	2735-2736	.	denotes	.
T7528	2736-2862	sentence	denotes	Loss of peripheral Rb KO ganglion cells is also evident from thinning of the optic nerve (D. C. and R. B., unpublished data).
T7529	2737-2741	NN	denotes	Loss
T7530	2777-2779	VBZ	denotes	is
T7531	2742-2744	IN	denotes	of
T7532	2745-2755	JJ	denotes	peripheral
T7533	2771-2776	NNS	denotes	cells
T7534	2756-2758	NN	denotes	Rb
T7535	2759-2761	NN	denotes	KO
T7536	2762-2770	NN	denotes	ganglion
T7537	2780-2784	RB	denotes	also
T7538	2785-2792	JJ	denotes	evident
T7539	2793-2797	IN	denotes	from
T7540	2798-2806	VBG	denotes	thinning
T7541	2807-2809	IN	denotes	of
T7542	2810-2813	DT	denotes	the
T7543	2820-2825	NN	denotes	nerve
T7544	2814-2819	JJ	denotes	optic
T7545	2826-2827	-LRB-	denotes	(
T7546	2827-2829	NNP	denotes	D.
T7547	2830-2832	NNP	denotes	C.
T7548	2833-2836	CC	denotes	and
T7549	2837-2839	NNP	denotes	R.
T7550	2840-2842	NNP	denotes	B.
T7551	2842-2844	,	denotes	,
T7552	2844-2855	JJ	denotes	unpublished
T7553	2856-2860	NNS	denotes	data
T7554	2860-2861	-RRB-	denotes	)
T7555	2861-2862	.	denotes	.
T7597	4373-4377	NN	denotes	role
T7598	4366-4372	JJ	denotes	unique
T7599	4378-4380	IN	denotes	of
T7600	4381-4385	NN	denotes	E2f1
T7601	4385-4387	,	denotes	,
T7602	4387-4389	PRP	denotes	we
T7603	4399-4402	DT	denotes	the
T7604	4403-4413	NN	denotes	expression
T7605	4414-4416	IN	denotes	of
T7606	4417-4422	JJ	denotes	known
T7607	4427-4434	NNS	denotes	targets
T7608	4423-4426	NN	denotes	E2f
T7609	4435-4437	RB	denotes	as
T7610	4443-4445	IN	denotes	as
T7611	4438-4442	RB	denotes	well
T7612	4446-4451	JJ	denotes	other
T7613	4452-4457	NNS	denotes	genes
T7614	4458-4462	WDT	denotes	that
T7615	4463-4471	VBP	denotes	regulate
T7616	4472-4475	DT	denotes	the
T7617	4481-4486	NN	denotes	cycle
T7618	4476-4480	NN	denotes	cell
T7619	4487-4490	CC	denotes	and
T7620	4491-4500	NN	denotes	apoptosis
T7621	4500-4501	.	denotes	.
T7622	4501-4619	sentence	denotes	Numerous positive and negative cell cycle and apoptotic regulators were up-regulated in the Rb KO retina (Figure 1H).
T7623	4502-4510	JJ	denotes	Numerous
T7624	4538-4543	NN	denotes	cycle
T7625	4511-4519	JJ	denotes	positive
T7626	4520-4523	CC	denotes	and
T7627	4524-4532	JJ	denotes	negative
T7628	4533-4537	NN	denotes	cell
T7629	4577-4586	VBN	denotes	regulated
T7630	4544-4547	CC	denotes	and
T7631	4548-4557	JJ	denotes	apoptotic
T7632	4558-4568	NNS	denotes	regulators
T7633	4569-4573	VBD	denotes	were
T7634	4574-4576	RB	denotes	up
T7635	4576-4577	HYPH	denotes	-
T7636	4587-4589	IN	denotes	in
T7637	4590-4593	DT	denotes	the
T7638	4600-4606	NN	denotes	retina
T7639	4594-4596	NN	denotes	Rb
T7640	4597-4599	NN	denotes	KO
T7641	4607-4608	-LRB-	denotes	(
T7642	4615-4617	NN	denotes	1H
T7643	4608-4614	NN	denotes	Figure
T7644	4617-4618	-RRB-	denotes	)
T7645	4618-4619	.	denotes	.
T7646	4619-4744	sentence	denotes	Among the E2f family, E2f1, E2f2, E2f3a, and E2f7 were induced following Rb loss, but E2f3b, E2f4, and E2f5 were unaffected.
T7647	4620-4625	IN	denotes	Among
T7648	4675-4682	VBN	denotes	induced
T7649	4626-4629	DT	denotes	the
T7650	4634-4640	NN	denotes	family
T7651	4630-4633	NN	denotes	E2f
T7652	4640-4642	,	denotes	,
T7653	4642-4646	NN	denotes	E2f1
T7654	4646-4648	,	denotes	,
T7655	4648-4652	NN	denotes	E2f2
T7656	4652-4654	,	denotes	,
T7657	4654-4659	NN	denotes	E2f3a
T7658	4659-4661	,	denotes	,
T7659	4661-4664	CC	denotes	and
T7660	4665-4669	NN	denotes	E2f7
T7661	4670-4674	VBD	denotes	were
T7662	4683-4692	VBG	denotes	following
T7663	4693-4695	NN	denotes	Rb
T7664	4696-4700	NN	denotes	loss
T7665	4700-4702	,	denotes	,
T7666	4702-4705	CC	denotes	but
T7667	4706-4711	NN	denotes	E2f3b
T7668	4728-4732	VBD	denotes	were
T7669	4711-4713	,	denotes	,
T7670	4713-4717	NN	denotes	E2f4
T7671	4717-4719	,	denotes	,
T7672	4719-4722	CC	denotes	and
T7673	4723-4727	NN	denotes	E2f5
T7674	4733-4743	JJ	denotes	unaffected
T7675	4743-4744	.	denotes	.
T7676	4744-4934	sentence	denotes	Consistent with the BrdU and terminal dUTP nick-end labelling (TUNEL) analyses, E2f1 deletion specifically reversed all these molecular defects, but E2f3 deletion had no effect (Figure 1H).
T7677	4745-4755	JJ	denotes	Consistent
T7678	4852-4860	VBD	denotes	reversed
T7679	4756-4760	IN	denotes	with
T7680	4761-4764	DT	denotes	the
T7681	4815-4823	NNS	denotes	analyses
T7682	4765-4769	NN	denotes	BrdU
T7683	4770-4773	CC	denotes	and
T7684	4774-4782	JJ	denotes	terminal
T7685	4797-4806	NN	denotes	labelling
T7686	4783-4787	NN	denotes	dUTP
T7687	4788-4792	NN	denotes	nick
T7688	4792-4793	HYPH	denotes	-
T7689	4793-4796	NN	denotes	end
T7690	4807-4808	-LRB-	denotes	(
T7691	4808-4813	NN	denotes	TUNEL
T7692	4813-4814	-RRB-	denotes	)
T7693	4823-4825	,	denotes	,
T7694	4825-4829	NN	denotes	E2f1
T7695	4830-4838	NN	denotes	deletion
T7696	4839-4851	RB	denotes	specifically
T7697	4861-4864	PDT	denotes	all
T7698	4881-4888	NNS	denotes	defects
T7699	4865-4870	DT	denotes	these
T7700	4871-4880	JJ	denotes	molecular
T7701	4888-4890	,	denotes	,
T7702	4890-4893	CC	denotes	but
T7703	4894-4898	NN	denotes	E2f3
T7704	4899-4907	NN	denotes	deletion
T7705	4908-4911	VBD	denotes	had
T7706	4912-4914	DT	denotes	no
T7707	4915-4921	NN	denotes	effect
T7708	4922-4923	-LRB-	denotes	(
T7709	4930-4932	NN	denotes	1H
T7710	4923-4929	NN	denotes	Figure
T7711	4932-4933	-RRB-	denotes	)
T7712	4933-4934	.	denotes	.
T34466	3239-3241	,	denotes	,
T34416	2997-3001	NN	denotes	E2f1
T34417	3002-3010	NN	denotes	Deletion
T34418	3011-3018	VBZ	denotes	Rescues
T34419	3019-3027	NN	denotes	Ganglion
T34420	3046-3051	NNS	denotes	Cells
T34421	3027-3029	,	denotes	,
T34422	3029-3032	NN	denotes	Rod
T34423	3032-3034	,	denotes	,
T34424	3034-3037	CC	denotes	and
T34425	3038-3045	JJ	denotes	Bipolar
T34426	3052-3054	IN	denotes	in
T34427	3055-3058	DT	denotes	the
T34428	3065-3071	NN	denotes	Retina
T34429	3059-3061	NN	denotes	Rb
T34430	3062-3064	NN	denotes	KO
T34431	3071-3338	sentence	denotes	(A) Horizontal retinal sections from mice of the indicated ages and genotypes were stained for nuclei (DAPI, blue) and markers that detect ganglion cells (Pou4f2, red), rods and cones (Sag [rod arrestin], green), and rod bipolar cells (Prkca, green, and Cabp5, red).
T34432	3072-3073	-LRB-	denotes	(
T34433	3073-3074	LS	denotes	A
T34434	3155-3162	VBN	denotes	stained
T34435	3074-3075	-RRB-	denotes	)
T34436	3076-3086	JJ	denotes	Horizontal
T34437	3095-3103	NNS	denotes	sections
T34438	3087-3094	JJ	denotes	retinal
T34439	3104-3108	IN	denotes	from
T34440	3109-3113	NNS	denotes	mice
T34441	3114-3116	IN	denotes	of
T34442	3117-3120	DT	denotes	the
T34443	3131-3135	NNS	denotes	ages
T34444	3121-3130	VBN	denotes	indicated
T34445	3136-3139	CC	denotes	and
T34446	3140-3149	NNS	denotes	genotypes
T34447	3150-3154	VBD	denotes	were
T34448	3163-3166	IN	denotes	for
T34449	3167-3173	NNS	denotes	nuclei
T34450	3174-3175	-LRB-	denotes	(
T34451	3181-3185	JJ	denotes	blue
T34452	3175-3179	NN	denotes	DAPI
T34453	3179-3181	,	denotes	,
T34454	3185-3186	-RRB-	denotes	)
T34455	3187-3190	CC	denotes	and
T34456	3191-3198	NNS	denotes	markers
T34457	3199-3203	WDT	denotes	that
T34458	3204-3210	VBP	denotes	detect
T34459	3211-3219	NN	denotes	ganglion
T34460	3220-3225	NNS	denotes	cells
T34461	3226-3227	-LRB-	denotes	(
T34462	3235-3238	JJ	denotes	red
T34463	3227-3233	NN	denotes	Pou4f2
T34464	3233-3235	,	denotes	,
T34465	3238-3239	-RRB-	denotes	)
T34467	3241-3245	NNS	denotes	rods
T34468	3246-3249	CC	denotes	and
T34469	3250-3255	NNS	denotes	cones
T34470	3256-3257	-LRB-	denotes	(
T34471	3277-3282	JJ	denotes	green
T34472	3257-3260	NN	denotes	Sag
T34473	3261-3262	-LRB-	denotes	[
T34474	3262-3265	NN	denotes	rod
T34475	3266-3274	NN	denotes	arrestin
T34476	3274-3275	-RRB-	denotes	]
T34477	3275-3277	,	denotes	,
T34478	3282-3283	-RRB-	denotes	)
T34479	3283-3285	,	denotes	,
T34480	3285-3288	CC	denotes	and
T34481	3289-3292	NN	denotes	rod
T34482	3301-3306	NNS	denotes	cells
T34483	3293-3300	JJ	denotes	bipolar
T34484	3307-3308	-LRB-	denotes	(
T34485	3315-3320	JJ	denotes	green
T34486	3308-3313	NN	denotes	Prkca
T34487	3313-3315	,	denotes	,
T34488	3320-3322	,	denotes	,
T34489	3322-3325	CC	denotes	and
T34490	3326-3331	NN	denotes	Cabp5
T34491	3333-3336	JJ	denotes	red
T34492	3331-3333	,	denotes	,
T34493	3336-3337	-RRB-	denotes	)
T34494	3337-3338	.	denotes	.
T34495	3338-3360	sentence	denotes	Scale bars are 50 μm.
T34496	3339-3344	NN	denotes	Scale
T34497	3345-3349	NNS	denotes	bars
T34498	3350-3353	VBP	denotes	are
T34499	3354-3356	CD	denotes	50
T34500	3357-3359	NN	denotes	μm
T34501	3359-3360	.	denotes	.
T34502	3360-3406	sentence	denotes	(B) Quantification of Pou4f2+ ganglion cells.
T34503	3361-3362	-LRB-	denotes	(
T34504	3362-3363	LS	denotes	B
T34505	3365-3379	NN	denotes	Quantification
T34506	3363-3364	-RRB-	denotes	)
T34507	3380-3382	IN	denotes	of
T34508	3383-3389	NN	denotes	Pou4f2
T34509	3400-3405	NNS	denotes	cells
T34510	3389-3390	SYM	denotes	+
T34511	3391-3399	NN	denotes	ganglion
T34512	3405-3406	.	denotes	.
T34513	3406-3461	sentence	denotes	(C) Quantification of Prkca+ and Cabp5+ bipolar cells.
T34514	3407-3408	-LRB-	denotes	(
T34515	3408-3409	LS	denotes	C
T34516	3411-3425	NN	denotes	Quantification
T34517	3409-3410	-RRB-	denotes	)
T34518	3426-3428	IN	denotes	of
T34519	3429-3434	NN	denotes	Prkca
T34520	3455-3460	NNS	denotes	cells
T34521	3434-3435	SYM	denotes	+
T34522	3436-3439	CC	denotes	and
T34523	3440-3445	NN	denotes	Cabp5
T34524	3445-3446	SYM	denotes	+
T34525	3447-3454	JJ	denotes	bipolar
T34526	3460-3461	.	denotes	.
T34527	3461-3524	sentence	denotes	(D) Thickness of the ONL, which represents the number of rods.
T34528	3462-3463	-LRB-	denotes	(
T34529	3463-3464	LS	denotes	D
T34530	3466-3475	NN	denotes	Thickness
T34531	3464-3465	-RRB-	denotes	)
T34532	3476-3478	IN	denotes	of
T34533	3479-3482	DT	denotes	the
T34534	3483-3486	NN	denotes	ONL
T34535	3486-3488	,	denotes	,
T34536	3488-3493	WDT	denotes	which
T34537	3494-3504	VBZ	denotes	represents
T34538	3505-3508	DT	denotes	the
T34539	3509-3515	NN	denotes	number
T34540	3516-3518	IN	denotes	of
T34541	3519-3523	NNS	denotes	rods
T34542	3523-3524	.	denotes	.
T34543	3524-3785	sentence	denotes	Error bars represent SD of measurements from three animals, and asterisks indicate a significant difference between retinas of WT and the indicated genotypes, unless indicated otherwise by connecting lines (, p < 0.05; *; p < 0.01; ANOVA and Tukey HSD test).
T34544	3525-3530	NN	denotes	Error
T34545	3531-3535	NNS	denotes	bars
T34546	3536-3545	VBP	denotes	represent
T34547	3546-3548	NN	denotes	SD
T34548	3549-3551	IN	denotes	of
T34549	3552-3564	NNS	denotes	measurements
T34550	3565-3569	IN	denotes	from
T34551	3570-3575	CD	denotes	three
T34552	3576-3583	NNS	denotes	animals
T34553	3583-3585	,	denotes	,
T34554	3585-3588	CC	denotes	and
T34555	3589-3598	NNS	denotes	asterisks
T34556	3599-3607	VBP	denotes	indicate
T34557	3608-3609	DT	denotes	a
T34558	3622-3632	NN	denotes	difference
T34559	3610-3621	JJ	denotes	significant
T34560	3633-3640	IN	denotes	between
T34561	3641-3648	NNS	denotes	retinas
T34562	3649-3651	IN	denotes	of
T34563	3652-3654	NN	denotes	WT
T34564	3655-3658	CC	denotes	and
T34565	3659-3662	DT	denotes	the
T34566	3663-3672	VBN	denotes	indicated
T34567	3673-3682	NNS	denotes	genotypes
T34568	3682-3684	,	denotes	,
T34569	3684-3690	IN	denotes	unless
T34570	3691-3700	VBN	denotes	indicated
T34571	3701-3710	RB	denotes	otherwise
T34572	3711-3713	IN	denotes	by
T34573	3714-3724	VBG	denotes	connecting
T34574	3725-3730	NNS	denotes	lines
T34575	3731-3732	-LRB-	denotes	(
T34576	3779-3783	NN	denotes	test
T34577	3732-3733	SYM	denotes	*
T34578	3739-3743	CD	denotes	0.05
T34579	3733-3735	,	denotes	,
T34580	3735-3736	NN	denotes	p
T34581	3737-3738	SYM	denotes	<
T34582	3743-3744	:	denotes	;
T34583	3745-3747	SYM	denotes	**
T34584	3753-3757	CD	denotes	0.01
T34585	3747-3748	:	denotes	;
T34586	3749-3750	NN	denotes	p
T34587	3751-3752	SYM	denotes	<
T34588	3757-3758	:	denotes	;
T34589	3759-3764	NN	denotes	ANOVA
T34590	3765-3768	CC	denotes	and
T34591	3769-3774	NNP	denotes	Tukey
T34592	3775-3778	NN	denotes	HSD
T34593	3783-3784	-RRB-	denotes	)
T34594	3784-3785	.	denotes	.
T34595	3785-4007	sentence	denotes	(E and F) ERGs were recorded from the indicated genotypes under dark-adapted (scotopic) conditions, and (E) intensity series and (F) b-wave amplitudes as a function of the logarithm of the flash intensity were determined.
T34596	3786-3787	-LRB-	denotes	(
T34597	3787-3788	LS	denotes	E
T34598	3806-3814	VBN	denotes	recorded
T34599	3789-3792	CC	denotes	and
T34600	3793-3794	LS	denotes	F
T34601	3794-3795	-RRB-	denotes	)
T34602	3796-3800	NNS	denotes	ERGs
T34603	3801-3805	VBD	denotes	were
T34604	3815-3819	IN	denotes	from
T34605	3820-3823	DT	denotes	the
T34606	3834-3843	NNS	denotes	genotypes
T34607	3824-3833	VBN	denotes	indicated
T34608	3844-3849	IN	denotes	under
T34609	3850-3854	NN	denotes	dark
T34610	3855-3862	VBN	denotes	adapted
T34611	3854-3855	HYPH	denotes	-
T34612	3874-3884	NNS	denotes	conditions
T34613	3863-3864	-LRB-	denotes	(
T34614	3864-3872	JJ	denotes	scotopic
T34615	3872-3873	-RRB-	denotes	)
T34616	3884-3886	,	denotes	,
T34617	3886-3889	CC	denotes	and
T34618	3890-3891	-LRB-	denotes	(
T34619	3891-3892	NN	denotes	E
T34620	3904-3910	NN	denotes	series
T34621	3892-3893	-RRB-	denotes	)
T34622	3894-3903	NN	denotes	intensity
T34623	3996-4006	VBN	denotes	determined
T34624	3911-3914	CC	denotes	and
T34625	3915-3916	-LRB-	denotes	(
T34626	3916-3917	NN	denotes	F
T34627	3926-3936	NNS	denotes	amplitudes
T34628	3917-3918	-RRB-	denotes	)
T34629	3919-3920	NN	denotes	b
T34630	3921-3925	NN	denotes	wave
T34631	3920-3921	HYPH	denotes	-
T34632	3937-3939	IN	denotes	as
T34633	3940-3941	DT	denotes	a
T34634	3942-3950	NN	denotes	function
T34635	3951-3953	IN	denotes	of
T34636	3954-3957	DT	denotes	the
T34637	3958-3967	NN	denotes	logarithm
T34638	3968-3970	IN	denotes	of
T34639	3971-3974	DT	denotes	the
T34640	3981-3990	NN	denotes	intensity
T34641	3975-3980	NN	denotes	flash
T34642	3991-3995	VBD	denotes	were
T34643	4006-4007	.	denotes	.
T34644	4007-4307	sentence	denotes	(F) Further illustrates that the relative influence of the mutations on the photoreceptors (indicated by the saturated a-wave amplitude, right graph) was not substantially different from their effect on the b-wave response (dominated by the bipolars, left graph) at the same intensity of 10 cd·s/m2.
T34645	4008-4009	-LRB-	denotes	(
T34646	4020-4031	VBZ	denotes	illustrates
T34647	4009-4010	NN	denotes	F
T34648	4010-4011	-RRB-	denotes	)
T34649	4012-4019	RB	denotes	Further
T34650	4032-4036	IN	denotes	that
T34651	4158-4161	VBD	denotes	was
T34652	4037-4040	DT	denotes	the
T34653	4050-4059	NN	denotes	influence
T34654	4041-4049	JJ	denotes	relative
T34655	4060-4062	IN	denotes	of
T34656	4063-4066	DT	denotes	the
T34657	4067-4076	NNS	denotes	mutations
T34658	4077-4079	IN	denotes	on
T34659	4080-4083	DT	denotes	the
T34660	4084-4098	NNS	denotes	photoreceptors
T34661	4099-4100	-LRB-	denotes	(
T34662	4100-4109	VBN	denotes	indicated
T34663	4110-4112	IN	denotes	by
T34664	4113-4116	DT	denotes	the
T34665	4134-4143	NN	denotes	amplitude
T34666	4117-4126	VBN	denotes	saturated
T34667	4127-4128	NN	denotes	a
T34668	4129-4133	NN	denotes	wave
T34669	4128-4129	HYPH	denotes	-
T34670	4143-4145	,	denotes	,
T34671	4151-4156	NN	denotes	graph
T34672	4145-4150	JJ	denotes	right
T34673	4156-4157	-RRB-	denotes	)
T34674	4162-4165	RB	denotes	not
T34675	4166-4179	RB	denotes	substantially
T34676	4180-4189	JJ	denotes	different
T34677	4190-4194	IN	denotes	from
T34678	4195-4200	PRP$	denotes	their
T34679	4201-4207	NN	denotes	effect
T34680	4208-4210	IN	denotes	on
T34681	4211-4214	DT	denotes	the
T34682	4222-4230	NN	denotes	response
T34683	4215-4216	NN	denotes	b
T34684	4217-4221	NN	denotes	wave
T34685	4216-4217	HYPH	denotes	-
T34686	4231-4232	-LRB-	denotes	(
T34687	4232-4241	VBN	denotes	dominated
T34688	4242-4244	IN	denotes	by
T34689	4245-4248	DT	denotes	the
T34690	4249-4257	NNS	denotes	bipolars
T34691	4257-4259	,	denotes	,
T34692	4264-4269	NN	denotes	graph
T34693	4259-4263	JJ	denotes	left
T34694	4269-4270	-RRB-	denotes	)
T34695	4271-4273	IN	denotes	at
T34696	4274-4277	DT	denotes	the
T34697	4283-4292	NN	denotes	intensity
T34698	4278-4282	JJ	denotes	same
T34699	4293-4295	IN	denotes	of
T34700	4296-4298	CD	denotes	10
T34701	4302-4303	NN	denotes	s
T34702	4299-4301	NN	denotes	cd
T34703	4301-4302	SYM	denotes	·
T34704	4303-4304	SYM	denotes	/
T34705	4304-4306	NN	denotes	m2
T34706	4306-4307	.	denotes	.
T7556	2862-2986	sentence	denotes	Deleting E2f1, but not E2f2 or E2f3, blocked this ectopic cell death in a dose-dependent fashion (Figures 1D, 1G, and S1B).
T7557	2863-2871	VBG	denotes	Deleting
T7558	2900-2907	VBD	denotes	blocked
T7559	2872-2876	NN	denotes	E2f1
T7560	2876-2878	,	denotes	,
T7561	2878-2881	CC	denotes	but
T7562	2882-2885	RB	denotes	not
T7563	2886-2890	NN	denotes	E2f2
T7564	2891-2893	CC	denotes	or
T7565	2894-2898	NN	denotes	E2f3
T7566	2898-2900	,	denotes	,
T7567	2908-2912	DT	denotes	this
T7568	2926-2931	NN	denotes	death
T7569	2913-2920	JJ	denotes	ectopic
T7570	2921-2925	NN	denotes	cell
T7571	2932-2934	IN	denotes	in
T7572	2935-2936	DT	denotes	a
T7573	2952-2959	NN	denotes	fashion
T7574	2937-2941	NN	denotes	dose
T7575	2942-2951	JJ	denotes	dependent
T7576	2941-2942	HYPH	denotes	-
T7577	2960-2961	-LRB-	denotes	(
T7578	2969-2971	NN	denotes	1D
T7579	2961-2968	NNS	denotes	Figures
T7580	2971-2973	,	denotes	,
T7581	2973-2975	NN	denotes	1G
T7582	2975-2977	,	denotes	,
T7583	2977-2980	CC	denotes	and
T7584	2981-2984	NN	denotes	S1B
T7585	2984-2985	-RRB-	denotes	)
T7586	2985-2986	.	denotes	.
T7587	2986-4501	sentence	denotes	Figure 2 E2f1 Deletion Rescues Ganglion, Rod, and Bipolar Cells in the Rb KO Retina (A) Horizontal retinal sections from mice of the indicated ages and genotypes were stained for nuclei (DAPI, blue) and markers that detect ganglion cells (Pou4f2, red), rods and cones (Sag [rod arrestin], green), and rod bipolar cells (Prkca, green, and Cabp5, red). Scale bars are 50 μm. (B) Quantification of Pou4f2+ ganglion cells. (C) Quantification of Prkca+ and Cabp5+ bipolar cells. (D) Thickness of the ONL, which represents the number of rods. Error bars represent SD of measurements from three animals, and asterisks indicate a significant difference between retinas of WT and the indicated genotypes, unless indicated otherwise by connecting lines (, p < 0.05; *; p < 0.01; ANOVA and Tukey HSD test). (E and F) ERGs were recorded from the indicated genotypes under dark-adapted (scotopic) conditions, and (E) intensity series and (F) b-wave amplitudes as a function of the logarithm of the flash intensity were determined. (F) Further illustrates that the relative influence of the mutations on the photoreceptors (indicated by the saturated a-wave amplitude, right graph) was not substantially different from their effect on the b-wave response (dominated by the bipolars, left graph) at the same intensity of 10 cd·s/m2. To investigate the molecular mechanism that underlies the unique role of E2f1, we assessed the expression of known E2f targets as well as other genes that regulate the cell cycle and apoptosis.
T7588	4308-4310	TO	denotes	To
T7589	4311-4322	VB	denotes	investigate
T7590	4390-4398	VBD	denotes	assessed
T7591	4323-4326	DT	denotes	the
T7592	4337-4346	NN	denotes	mechanism
T7593	4327-4336	JJ	denotes	molecular
T7594	4347-4351	WDT	denotes	that
T7595	4352-4361	VBZ	denotes	underlies
T7596	4362-4365	DT	denotes	the
R1519	T6888	T6889	nsubj	Rb,Regulates
R1520	T6890	T6889	dobj	Division,Regulates
R1521	T6891	T6890	cc	and,Division
R1522	T6892	T6890	conj	Death,Division
R1523	T6893	T6889	prep	through,Regulates
R1524	T6894	T6893	pobj	E2f1,through
R1525	T6896	T6897	nsubj	We,used
R1526	T6898	T6899	det	the,transgene
R1527	T6899	T6897	dobj	transgene,used
R1528	T6900	T6901	compound	α,Cre
R1529	T6901	T6899	compound	Cre,transgene
R1530	T6902	T6901	punct	-,Cre
R1531	T6903	T6904	aux	to,delete
R1532	T6904	T6897	advcl	delete,used
R1533	T6905	T6906	amod	floxed,exon
R1534	T6906	T6904	dobj	exon,delete
R1535	T6907	T6906	compound	Rb,exon
R1536	T6908	T6906	nummod	19,exon
R1537	T6909	T6904	prep	at,delete
R1538	T6910	T6911	amod	embryonic,day
R1539	T6911	T6909	pobj	day,at
R1540	T6912	T6911	punct	(,day
R1541	T6913	T6911	appos	E,day
R1542	T6914	T6911	punct	),day
R1543	T6915	T6911	nummod	10,day
R1544	T6916	T6904	prep	in,delete
R1545	T6917	T6918	amod	peripheral,retina
R1546	T6918	T6916	pobj	retina,in
R1547	T6919	T6920	punct	[,2
R1548	T6920	T6897	parataxis	2,used
R1549	T6921	T6920	punct	],2
R1550	T6922	T6897	punct	.,used
R1551	T6924	T6925	nmod	RbloxP,loxP
R1552	T6925	T6927	nmod	loxP,mice
R1553	T6926	T6925	punct	/,loxP
R1554	T6927	T6932	nsubjpass	mice,bred
R1555	T6928	T6925	punct	;,loxP
R1556	T6929	T6930	compound	α,Cre
R1557	T6930	T6925	appos	Cre,loxP
R1558	T6931	T6930	punct	-,Cre
R1559	T6933	T6932	auxpass	were,bred
R1560	T6934	T6932	prep	with,bred
R1561	T6935	T6934	pobj	strains,with
R1562	T6936	T6935	acl	lacking,strains
R1563	T6937	T6936	dobj	E2f1,lacking
R1564	T6938	T6937	cc	or,E2f1
R1565	T6939	T6937	conj	E2f2,E2f1
R1566	T6940	T6936	prep	in,lacking
R1567	T6941	T6942	det	the,line
R1568	T6942	T6940	pobj	line,in
R1569	T6943	T6942	compound	germ,line
R1570	T6944	T6935	punct	", ",strains
R1571	T6945	T6935	cc	or,strains
R1572	T6946	T6947	det	a,strain
R1573	T6947	T6935	conj	strain,strains
R1574	T6948	T6947	acl	carrying,strain
R1575	T6949	T6950	det	a,allele
R1576	T6950	T6948	dobj	allele,carrying
R1577	T6951	T6950	amod	floxed,allele
R1578	T6952	T6950	compound	E2f3,allele
R1579	T6953	T6954	punct	[,5
R1580	T6954	T6932	parataxis	5,bred
R1581	T6955	T6954	punct	],5
R1582	T6956	T6932	punct	.,bred
R1583	T6958	T6959	nmod	RbloxP,loxP
R1584	T6959	T6961	nmod	loxP,mice
R1585	T6960	T6959	punct	/,loxP
R1586	T6961	T6980	nsubjpass	mice,bred
R1587	T6962	T6959	punct	;,loxP
R1588	T6963	T6959	appos	E2f1,loxP
R1589	T6964	T6963	punct	+,E2f1
R1590	T6965	T6963	punct	/,E2f1
R1591	T6966	T6963	punct	−,E2f1
R1592	T6967	T6959	cc	and,loxP
R1593	T6968	T6969	compound	RbloxP,loxP
R1594	T6969	T6959	conj	loxP,loxP
R1595	T6970	T6969	punct	/,loxP
R1596	T6971	T6969	punct	;,loxP
R1597	T6972	T6969	appos	E2f1,loxP
R1598	T6973	T6972	punct	+,E2f1
R1599	T6974	T6972	punct	/,E2f1
R1600	T6975	T6972	punct	−,E2f1
R1601	T6976	T6959	punct	;,loxP
R1602	T6977	T6978	compound	α,Cre
R1603	T6978	T6959	appos	Cre,loxP
R1604	T6979	T6978	punct	-,Cre
R1605	T6981	T6980	auxpass	were,bred
R1606	T6982	T6983	aux	to,produce
R1607	T6983	T6980	advcl	produce,bred
R1608	T6984	T6985	nmod	RbloxP,loxP
R1609	T6985	T6987	nmod	loxP,mice
R1610	T6986	T6985	punct	/,loxP
R1611	T6987	T6983	dobj	mice,produce
R1612	T6988	T6985	punct	;,loxP
R1613	T6989	T6985	appos	E2f1,loxP
R1614	T6990	T6989	punct	−,E2f1
R1615	T6991	T6989	punct	/,E2f1
R1616	T6992	T6989	punct	−,E2f1
R1617	T6993	T6985	punct	;,loxP
R1618	T6994	T6995	compound	α,Cre
R1619	T6995	T6985	appos	Cre,loxP
R1620	T6996	T6995	punct	-,Cre
R1621	T6997	T6983	prep	at,produce
R1622	T6998	T6999	det	a,frequency
R1623	T6999	T6997	pobj	frequency,at
R1624	T7000	T6999	prep	of,frequency
R1625	T7001	T7002	nummod	1,8
R1626	T7002	T7000	pobj	8,of
R1627	T7003	T7002	punct	/,8
R1628	T7004	T6980	cc	and,bred
R1629	T7005	T7006	compound	littermate,controls
R1630	T7006	T6980	conj	controls,bred
R1631	T7007	T7006	prep	at,controls
R1632	T7008	T7009	det	the,same
R1633	T7009	T7007	pobj	same,at
R1634	T7010	T7009	cc	or,same
R1635	T7011	T7012	nmod	higher,frequency
R1636	T7012	T7009	conj	frequency,same
R1637	T7013	T7014	punct	(,1
R1638	T7014	T7011	parataxis	1,higher
R1639	T7015	T7016	punct	/,4
R1640	T7016	T7014	prep	4,1
R1641	T7017	T7014	punct	),1
R1642	T7018	T7006	punct	.,controls
R1643	T7020	T7021	prep	For,refer
R1644	T7022	T7020	pobj	simplicity,For
R1645	T7023	T7021	nsubj	we,refer
R1646	T7024	T7021	aux	will,refer
R1647	T7025	T7021	prep	to,refer
R1648	T7026	T7027	det	the,retina
R1649	T7027	T7025	pobj	retina,to
R1650	T7028	T7029	nmod	RbloxP,loxP
R1651	T7029	T7027	nmod	loxP,retina
R1652	T7030	T7029	punct	/,loxP
R1653	T7031	T7029	punct	;,loxP
R1654	T7032	T7029	appos	E2f1,loxP
R1655	T7033	T7032	punct	−,E2f1
R1656	T7034	T7032	punct	/,E2f1
R1657	T7035	T7032	punct	−,E2f1
R1658	T7036	T7029	punct	;,loxP
R1659	T7037	T7038	compound	α,Cre
R1660	T7038	T7029	appos	Cre,loxP
R1661	T7039	T7038	punct	-,Cre
R1662	T7040	T7027	amod	peripheral,retina
R1663	T7041	T7021	prep	as,refer
R1664	T7042	T7043	det	the,retina
R1665	T7043	T7041	pobj	retina,as
R1666	T7044	T7045	nmod	Rb,E2f1
R1667	T7045	T7043	nmod	E2f1,retina
R1668	T7046	T7045	punct	/,E2f1
R1669	T7047	T7048	amod	double,knockout
R1670	T7048	T7045	appos	knockout,E2f1
R1671	T7049	T7048	punct	(,knockout
R1672	T7050	T7048	appos	DKO,knockout
R1673	T7051	T7043	punct	),retina
R1674	T7052	T7021	punct	.,refer
R1675	T7054	T7055	amod	Similar,strategies
R1676	T7055	T7056	nsubjpass	strategies,employed
R1677	T7057	T7056	auxpass	were,employed
R1678	T7058	T7056	prep	in,employed
R1679	T7059	T7060	det	the,case
R1680	T7060	T7058	pobj	case,in
R1681	T7061	T7060	prep	of,case
R1682	T7062	T7061	pobj	E2f2,of
R1683	T7063	T7062	cc	or,E2f2
R1684	T7064	T7062	conj	E2f3,E2f2
R1685	T7065	T7056	punct	.,employed
R1686	T7067	T7068	npadvmod	Cre,mediated
R1687	T7068	T7070	amod	mediated,excision
R1688	T7069	T7068	punct	-,mediated
R1689	T7070	T7071	nsubjpass	excision,confirmed
R1690	T7072	T7070	prep	of,excision
R1691	T7073	T7074	nmod	Rb,alleles
R1692	T7074	T7072	pobj	alleles,of
R1693	T7075	T7073	cc	and,Rb
R1694	T7076	T7073	conj	E2f3,Rb
R1695	T7077	T7070	prep	in,excision
R1696	T7078	T7079	det	the,retina
R1697	T7079	T7077	pobj	retina,in
R1698	T7080	T7071	auxpass	was,confirmed
R1699	T7081	T7071	prep	by,confirmed
R1700	T7082	T7081	pobj	PCR,by
R1701	T7083	T7084	mark	as,described
R1702	T7084	T7071	advcl	described,confirmed
R1703	T7085	T7084	advmod	previously,described
R1704	T7086	T7087	punct	[,5
R1705	T7087	T7071	parataxis	5,confirmed
R1706	T7088	T7087	nummod	2,5
R1707	T7089	T7087	punct	",",5
R1708	T7090	T7087	punct	],5
R1709	T7091	T7071	punct	.,confirmed
R1710	T7093	T7094	aux	To,measure
R1711	T7094	T7095	advcl	measure,labelled
R1712	T7096	T7097	amod	ectopic,division
R1713	T7097	T7094	dobj	division,measure
R1714	T7098	T7097	compound	cell,division
R1715	T7099	T7095	punct	", ",labelled
R1716	T7100	T7095	nsubjpass	mice,labelled
R1717	T7101	T7095	auxpass	were,labelled
R1718	T7102	T7095	dep	pulse,labelled
R1719	T7103	T7095	punct	-,labelled
R1720	T7104	T7095	prep	with,labelled
R1721	T7105	T7104	pobj	bromodeoxyuridine,with
R1722	T7106	T7105	punct	(,bromodeoxyuridine
R1723	T7107	T7105	appos	BrdU,bromodeoxyuridine
R1724	T7108	T7095	punct	),labelled
R1725	T7109	T7110	nummod	2,h
R1726	T7110	T7111	npadvmod	h,before
R1727	T7111	T7095	prep	before,labelled
R1728	T7112	T7111	pobj	sacrifice,before
R1729	T7113	T7095	cc	and,labelled
R1730	T7114	T7115	det	the,retina
R1731	T7115	T7117	nsubj	retina,analyzed
R1732	T7116	T7115	amod	peripheral,retina
R1733	T7117	T7095	conj	analyzed,labelled
R1734	T7118	T7117	prep	for,analyzed
R1735	T7119	T7120	compound	BrdU,incorporation
R1736	T7120	T7118	pobj	incorporation,for
R1737	T7121	T7117	prep	by,analyzed
R1738	T7122	T7121	pobj	immunofluorescence,by
R1739	T7123	T7095	punct	.,labelled
R1740	T7125	T7126	mark	As,reported
R1741	T7126	T7127	advcl	reported,exhibited
R1742	T7128	T7126	advmod	before,reported
R1743	T7129	T7130	punct	[,3
R1744	T7130	T7126	parataxis	3,reported
R1745	T7131	T7130	nummod	2,3
R1746	T7132	T7130	punct	",",3
R1747	T7133	T7130	punct	],3
R1748	T7134	T7127	dep	", ",exhibited
R1749	T7135	T7136	compound	Rb,KO
R1750	T7136	T7137	compound	KO,retinas
R1751	T7137	T7127	nsubj	retinas,exhibited
R1752	T7138	T7139	preconj	both,spatial
R1753	T7139	T7140	amod	spatial,synthesis
R1754	T7140	T7127	dobj	synthesis,exhibited
R1755	T7141	T7139	cc	and,spatial
R1756	T7142	T7139	conj	temporal,spatial
R1757	T7143	T7140	amod	ectopic,synthesis
R1758	T7144	T7140	compound	DNA,synthesis
R1759	T7145	T7146	punct	(,1C
R1760	T7146	T7127	parataxis	1C,exhibited
R1761	T7147	T7146	compound	Figures,1C
R1762	T7148	T7146	cc	and,1C
R1763	T7149	T7146	conj	S1A,1C
R1764	T7150	T7146	punct	),1C
R1765	T7151	T7127	punct	.,exhibited
R1766	T7153	T7154	nsubjpass	This,detected
R1767	T7155	T7154	auxpass	is,detected
R1768	T7156	T7154	advmod	easily,detected
R1769	T7157	T7154	prep	at,detected
R1770	T7158	T7157	pobj	E14,at
R1771	T7159	T7158	punct	", ",E14
R1772	T7160	T7158	conj	E16,E14
R1773	T7161	T7160	punct	", ",E16
R1774	T7162	T7160	cc	and,E16
R1775	T7163	T7164	amod	postnatal,day
R1776	T7164	T7160	conj	day,E16
R1777	T7165	T7164	punct	(,day
R1778	T7166	T7164	appos	P,day
R1779	T7167	T7164	punct	),day
R1780	T7168	T7164	nummod	0,day
R1781	T7169	T7154	prep	in,detected
R1782	T7170	T7171	det	the,retina
R1783	T7171	T7169	pobj	retina,in
R1784	T7172	T7171	amod	inner,retina
R1785	T7173	T7174	advmod	where,located
R1786	T7174	T7171	relcl	located,retina
R1787	T7175	T7176	amod	abnormal,RTCs
R1788	T7176	T7174	nsubjpass	RTCs,located
R1789	T7177	T7176	nmod	BrdU,RTCs
R1790	T7178	T7177	punct	+,BrdU
R1791	T7179	T7176	nmod	ganglion,RTCs
R1792	T7180	T7179	cc	and,ganglion
R1793	T7181	T7179	conj	amacrine,ganglion
R1794	T7182	T7174	auxpass	are,located
R1795	T7183	T7169	punct	", ",in
R1796	T7184	T7169	cc	or,in
R1797	T7185	T7169	conj	on,in
R1798	T7186	T7187	det	the,region
R1799	T7187	T7185	pobj	region,on
R1800	T7188	T7187	amod	outermost,region
R1801	T7189	T7187	prep	of,region
R1802	T7190	T7191	det	the,retina
R1803	T7191	T7189	pobj	retina,of
R1804	T7192	T7191	compound	P0,retina
R1805	T7193	T7191	punct	", ",retina
R1806	T7194	T7195	advmod	where,reside
R1807	T7195	T7191	relcl	reside,retina
R1808	T7196	T7197	nmod	BrdU,RTCs
R1809	T7197	T7195	nsubj	RTCs,reside
R1810	T7198	T7196	punct	+,BrdU
R1811	T7199	T7197	compound	photoreceptor,RTCs
R1812	T7200	T7201	punct	(,arrows
R1813	T7201	T7154	parataxis	arrows,detected
R1814	T7202	T7203	compound	Figures,S1A
R1815	T7203	T7201	dep	S1A,arrows
R1816	T7204	T7203	cc	and,S1A
R1817	T7205	T7203	conj	S2,S1A
R1818	T7206	T7201	punct	", ",arrows
R1819	T7207	T7201	punct	),arrows
R1820	T7208	T7209	punct	[,2
R1821	T7209	T7154	parataxis	2,detected
R1822	T7210	T7209	punct	],2
R1823	T7211	T7154	punct	.,detected
R1824	T7213	T7214	amod	Ectopic,division
R1825	T7214	T7216	nsubj	division,is
R1826	T7215	T7214	compound	RTC,division
R1827	T7217	T7214	prep	in,division
R1828	T7218	T7219	compound	Rb,KO
R1829	T7219	T7220	compound	KO,retinas
R1830	T7220	T7217	pobj	retinas,in
R1831	T7221	T7222	advmod	even,more
R1832	T7222	T7223	advmod	more,obvious
R1833	T7223	T7216	acomp	obvious,is
R1834	T7224	T7216	prep	at,is
R1835	T7225	T7224	pobj	P8,at
R1836	T7226	T7225	cc	or,P8
R1837	T7227	T7225	conj	P18,P8
R1838	T7228	T7225	punct	", ",P8
R1839	T7229	T7230	advmod	when,completed
R1840	T7230	T7225	relcl	completed,P8
R1841	T7231	T7230	nsubjpass	division,completed
R1842	T7232	T7230	auxpass	is,completed
R1843	T7233	T7230	prep	in,completed
R1844	T7234	T7235	amod	wild,type
R1845	T7235	T7237	nmod	type,retina
R1846	T7236	T7235	punct	-,type
R1847	T7237	T7233	pobj	retina,in
R1848	T7238	T7235	punct	(,type
R1849	T7239	T7235	appos	WT,type
R1850	T7240	T7237	punct	),retina
R1851	T7241	T7242	punct	(,1C
R1852	T7242	T7216	parataxis	1C,is
R1853	T7243	T7242	compound	Figures,1C
R1854	T7244	T7242	cc	and,1C
R1855	T7245	T7242	conj	S1A,1C
R1856	T7246	T7242	punct	),1C
R1857	T7247	T7216	punct	.,is
R1858	T7249	T7250	advmod	Strikingly,suppressed
R1859	T7251	T7250	punct	", ",suppressed
R1860	T7252	T7253	det	the,cells
R1861	T7253	T7250	nsubjpass	cells,suppressed
R1862	T7254	T7255	advmod	ectopically,positioned
R1863	T7255	T7253	amod	positioned,cells
R1864	T7256	T7257	compound	S,phase
R1865	T7257	T7253	compound	phase,cells
R1866	T7258	T7257	punct	-,phase
R1867	T7259	T7253	prep	at,cells
R1868	T7260	T7259	pobj	E14,at
R1869	T7261	T7260	punct	", ",E14
R1870	T7262	T7260	conj	E16,E14
R1871	T7263	T7262	punct	", ",E16
R1872	T7264	T7262	cc	and,E16
R1873	T7265	T7262	conj	P0,E16
R1874	T7266	T7253	cc	and,cells
R1875	T7267	T7268	predet	all,division
R1876	T7268	T7253	conj	division,cells
R1877	T7269	T7268	det	the,division
R1878	T7270	T7268	amod	abnormal,division
R1879	T7271	T7268	prep	at,division
R1880	T7272	T7271	pobj	P8,at
R1881	T7273	T7272	cc	and,P8
R1882	T7274	T7272	conj	P18,P8
R1883	T7275	T7250	auxpass	were,suppressed
R1884	T7276	T7250	advmod	completely,suppressed
R1885	T7277	T7250	prep	in,suppressed
R1886	T7278	T7279	det	the,retina
R1887	T7279	T7277	pobj	retina,in
R1888	T7280	T7281	compound	Rb,E2f1
R1889	T7281	T7283	compound	E2f1,DKO
R1890	T7282	T7281	punct	/,E2f1
R1891	T7283	T7279	compound	DKO,retina
R1892	T7284	T7285	punct	(,1C
R1893	T7285	T7250	parataxis	1C,suppressed
R1894	T7286	T7285	compound	Figures,1C
R1895	T7287	T7285	punct	", ",1C
R1896	T7288	T7285	conj	1E,1C
R1897	T7289	T7288	punct	", ",1E
R1898	T7290	T7288	conj	1F,1E
R1899	T7291	T7290	punct	", ",1F
R1900	T7292	T7290	conj	S1A,1F
R1901	T7293	T7292	punct	", ",S1A
R1902	T7294	T7292	cc	and,S1A
R1903	T7295	T7292	conj	S2,S1A
R1904	T7296	T7285	punct	),1C
R1905	T7297	T7250	punct	.,suppressed
R1906	T7299	T7300	prep	In,had
R1907	T7301	T7299	pobj	contrast,In
R1908	T7302	T7300	punct	", ",had
R1909	T7303	T7300	nsubj	deletion,had
R1910	T7304	T7303	prep	of,deletion
R1911	T7305	T7304	pobj	E2f2,of
R1912	T7306	T7305	cc	or,E2f2
R1913	T7307	T7305	conj	E2f3,E2f2
R1914	T7308	T7309	det	no,effect
R1915	T7309	T7300	dobj	effect,had
R1916	T7310	T7300	prep	at,had
R1917	T7311	T7312	det	any,stage
R1918	T7312	T7310	pobj	stage,at
R1919	T7313	T7312	prep	of,stage
R1920	T7314	T7313	pobj	development,of
R1921	T7315	T7300	punct	.,had
R1922	T7317	T7318	nsubj	Analysis,confirmed
R1923	T7319	T7317	prep	of,Analysis
R1924	T7320	T7321	amod	mitotic,cells
R1925	T7321	T7319	pobj	cells,of
R1926	T7322	T7317	prep	with,Analysis
R1927	T7323	T7324	npadvmod	anti–phosphohistone,specific
R1928	T7324	T7330	amod	specific,antibodies
R1929	T7325	T7323	nummod	3,anti–phosphohistone
R1930	T7326	T7323	punct	(,anti–phosphohistone
R1931	T7327	T7323	appos	PH3,anti–phosphohistone
R1932	T7328	T7324	punct	),specific
R1933	T7329	T7324	punct	–,specific
R1934	T7330	T7322	pobj	antibodies,with
R1935	T7331	T7332	mark	that,suppressed
R1936	T7332	T7318	ccomp	suppressed,confirmed
R1937	T7333	T7332	nsubj	loss,suppressed
R1938	T7334	T7333	prep	of,loss
R1939	T7335	T7334	pobj	E2f1,of
R1940	T7336	T7335	punct	", ",E2f1
R1941	T7337	T7335	cc	but,E2f1
R1942	T7338	T7337	neg	not,but
R1943	T7339	T7335	conj	E2f2,E2f1
R1944	T7340	T7339	cc	or,E2f2
R1945	T7341	T7339	conj	E2f3,E2f2
R1946	T7342	T7332	punct	", ",suppressed
R1947	T7343	T7344	amod	ectopic,division
R1948	T7344	T7332	dobj	division,suppressed
R1949	T7345	T7346	punct	(,S3
R1950	T7346	T7318	parataxis	S3,confirmed
R1951	T7347	T7346	compound	Figure,S3
R1952	T7348	T7346	punct	),S3
R1953	T7349	T7318	punct	.,confirmed
R1954	T7351	T7352	csubj	Deleting,suppressed
R1955	T7353	T7354	nummod	one,allele
R1956	T7354	T7351	dobj	allele,Deleting
R1957	T7355	T7354	compound	E2f1,allele
R1958	T7356	T7352	advmod	partially,suppressed
R1959	T7357	T7358	amod	ectopic,phase
R1960	T7358	T7352	dobj	phase,suppressed
R1961	T7359	T7358	compound	S,phase
R1962	T7360	T7358	punct	-,phase
R1963	T7361	T7358	cc	and,phase
R1964	T7362	T7358	conj	mitosis,phase
R1965	T7363	T7352	prep	in,suppressed
R1966	T7364	T7365	compound	Rb,KO
R1967	T7365	T7366	compound	KO,RTCs
R1968	T7366	T7363	pobj	RTCs,in
R1969	T7367	T7368	punct	(,1C
R1970	T7368	T7352	parataxis	1C,suppressed
R1971	T7369	T7368	compound	Figures,1C
R1972	T7370	T7368	punct	", ",1C
R1973	T7371	T7368	conj	1E,1C
R1974	T7372	T7371	punct	", ",1E
R1975	T7373	T7371	conj	1F,1E
R1976	T7374	T7373	punct	", ",1F
R1977	T7375	T7373	conj	S1A,1F
R1978	T7376	T7375	punct	", ",S1A
R1979	T7377	T7375	conj	S2,S1A
R1980	T7378	T7377	punct	", ",S2
R1981	T7379	T7377	cc	and,S2
R1982	T7380	T7377	conj	S3,S2
R1983	T7381	T7368	punct	),1C
R1984	T7382	T7352	punct	", ",suppressed
R1985	T7383	T7352	advcl	suggesting,suppressed
R1986	T7384	T7385	mark	that,drives
R1987	T7385	T7383	ccomp	drives,suggesting
R1988	T7386	T7385	nsubj	E2f1,drives
R1989	T7387	T7388	amod	ectopic,division
R1990	T7388	T7385	dobj	division,drives
R1991	T7389	T7385	prep	in,drives
R1992	T7390	T7391	compound	Rb,KO
R1993	T7391	T7392	compound	KO,RTCs
R1994	T7392	T7389	pobj	RTCs,in
R1995	T7393	T7385	prep	in,drives
R1996	T7394	T7395	det	a,fashion
R1997	T7395	T7393	pobj	fashion,in
R1998	T7450	T7448	dobj	cells,eliminating
R1999	T7396	T7397	npadvmod	dose,dependent
R2000	T7451	T7450	amod	bipolar,cells
R2001	T7397	T7395	amod	dependent,fashion
R2002	T7452	T7451	cc	and,bipolar
R2003	T7398	T7397	punct	-,dependent
R2004	T7453	T7451	conj	ganglion,bipolar
R2005	T7454	T7455	advmod	as,as
R2006	T7455	T7450	cc	as,cells
R2007	T7399	T7352	punct	.,suppressed
R2008	T7456	T7455	advmod	well,as
R2009	T7457	T7458	amod	many,rods
R2010	T7401	T7402	det	These,data
R2011	T7458	T7450	conj	rods,cells
R2012	T7459	T7460	punct	(,2A
R2013	T7460	T7448	parataxis	2A,eliminating
R2014	T7461	T7460	compound	Figure,2A
R2015	T7402	T7403	nsubj	data,contrast
R2016	T7462	T7463	punct	–,2D
R2017	T7463	T7460	prep	2D,2A
R2018	T7404	T7403	prep	with,contrast
R2019	T7464	T7460	punct	),2A
R2020	T7465	T7466	punct	[,3
R2021	T7466	T7448	parataxis	3,eliminating
R2022	T7467	T7466	nummod	2,3
R2023	T7405	T7406	amod	previous,findings
R2024	T7468	T7466	punct	",",3
R2025	T7469	T7466	punct	],3
R2026	T7406	T7404	pobj	findings,with
R2027	T7470	T7437	punct	.,results
R2028	T7407	T7403	prep	in,contrast
R2029	T7472	T7473	det	The,loss
R2030	T7473	T7474	nsubj	loss,is
R2031	T7475	T7473	prep	of,loss
R2032	T7476	T7477	compound	Rb,KO
R2033	T7408	T7409	det	the,lens
R2034	T7409	T7407	pobj	lens,in
R2035	T7477	T7478	compound	KO,rods
R2036	T7410	T7409	cc	and,lens
R2037	T7478	T7475	pobj	rods,of
R2038	T7479	T7474	acomp	evident,is
R2039	T7480	T7474	prep	from,is
R2040	T7411	T7409	conj	CNS,lens
R2041	T7481	T7482	det	the,ONL
R2042	T7412	T7409	prep	of,lens
R2043	T7482	T7480	pobj	ONL,from
R2044	T7483	T7482	amod	thinner,ONL
R2045	T7484	T7474	punct	", ",is
R2046	T7485	T7474	cc	and,is
R2047	T7413	T7414	compound	Rb,KO
R2048	T7486	T7487	det	the,death
R2049	T7487	T7488	nsubjpass	death,detected
R2050	T7414	T7415	compound	KO,embryos
R2051	T7488	T7474	conj	detected,is
R2052	T7489	T7487	prep	of,death
R2053	T7490	T7491	det	these,cells
R2054	T7415	T7412	pobj	embryos,of
R2055	T7491	T7489	pobj	cells,of
R2056	T7492	T7493	advmod	as,as
R2057	T7416	T7409	punct	", ",lens
R2058	T7493	T7491	cc	as,cells
R2059	T7494	T7493	advmod	well,as
R2060	T7495	T7496	amod	bipolar,neurons
R2061	T7417	T7418	advmod	where,suppresses
R2062	T7496	T7491	conj	neurons,cells
R2063	T7497	T7495	cc	and,bipolar
R2064	T7498	T7495	conj	ganglion,bipolar
R2065	T7418	T7409	relcl	suppresses,lens
R2066	T7499	T7488	aux	can,detected
R2067	T7500	T7488	auxpass	be,detected
R2068	T7501	T7488	advmod	directly,detected
R2069	T7419	T7418	nsubj	deletion,suppresses
R2070	T7502	T7488	prep	by,detected
R2071	T7503	T7504	advmod	double,labelling
R2072	T7420	T7419	prep	of,deletion
R2073	T7504	T7502	pcomp	labelling,by
R2074	T7505	T7504	prep	for,labelling
R2075	T7506	T7507	amod	apoptotic,markers
R2076	T7421	T7422	det	any,E2f
R2077	T7507	T7505	pobj	markers,for
R2078	T7508	T7506	cc	and,apoptotic
R2079	T7422	T7420	pobj	E2f,of
R2080	T7509	T7510	compound	cell,type
R2081	T7510	T7512	npadvmod	type,specific
R2082	T7511	T7510	punct	-,type
R2083	T7512	T7506	conj	specific,apoptotic
R2084	T7513	T7512	punct	-,specific
R2085	T7514	T7515	punct	[,2
R2086	T7423	T7422	amod	activating,E2f
R2087	T7515	T7488	parataxis	2,detected
R2088	T7516	T7515	punct	],2
R2089	T7517	T7518	punct	(,M.
R2090	T7424	T7425	amod	ectopic,division
R2091	T7518	T7488	meta	M.,detected
R2092	T7519	T7518	nmod	P.,M.
R2093	T7425	T7418	dobj	division,suppresses
R2094	T7520	T7518	cc	and,M.
R2095	T7521	T7518	conj	R.,M.
R2096	T7522	T7521	nmod	B.,R.
R2097	T7426	T7418	prep	to,suppresses
R2098	T7523	T7521	punct	", ",R.
R2099	T7524	T7525	amod	unpublished,data
R2100	T7525	T7521	conj	data,R.
R2101	T7427	T7428	det	some,extent
R2102	T7526	T7525	punct	),data
R2103	T7527	T7488	punct	.,detected
R2104	T7428	T7426	pobj	extent,to
R2105	T7529	T7530	nsubj	Loss,is
R2106	T7429	T7430	punct	[,6
R2107	T7531	T7529	prep	of,Loss
R2108	T7532	T7533	amod	peripheral,cells
R2109	T7533	T7531	pobj	cells,of
R2110	T7430	T7418	parataxis	6,suppresses
R2111	T7534	T7535	compound	Rb,KO
R2112	T7535	T7533	compound	KO,cells
R2113	T7536	T7533	compound	ganglion,cells
R2114	T7431	T7432	punct	–,9
R2115	T7537	T7530	advmod	also,is
R2116	T7538	T7530	acomp	evident,is
R2117	T7432	T7430	prep	9,6
R2118	T7539	T7530	prep	from,is
R2119	T7540	T7539	pobj	thinning,from
R2120	T7541	T7540	prep	of,thinning
R2121	T7433	T7430	punct	],6
R2122	T7542	T7543	det	the,nerve
R2123	T7543	T7541	pobj	nerve,of
R2124	T7544	T7543	amod	optic,nerve
R2125	T7434	T7403	punct	.,contrast
R2126	T7545	T7546	punct	(,D.
R2127	T7546	T7530	meta	D.,is
R2128	T7436	T7437	nsubj	Loss,results
R2129	T7547	T7546	nmod	C.,D.
R2130	T7548	T7546	cc	and,D.
R2131	T7549	T7546	conj	R.,D.
R2132	T7550	T7549	nmod	B.,R.
R2133	T7438	T7436	prep	of,Loss
R2134	T7551	T7549	punct	", ",R.
R2135	T7552	T7553	amod	unpublished,data
R2136	T7553	T7549	conj	data,R.
R2137	T7554	T7553	punct	),data
R2138	T7555	T7530	punct	.,is
R2139	T7439	T7438	pobj	Rb,of
R2140	T7440	T7436	prep	in,Loss
R2141	T7441	T7442	det	the,retina
R2142	T7557	T7558	csubj	Deleting,blocked
R2143	T7442	T7440	pobj	retina,in
R2144	T7559	T7557	dobj	E2f1,Deleting
R2145	T7560	T7559	punct	", ",E2f1
R2146	T7443	T7437	prep	in,results
R2147	T7561	T7559	cc	but,E2f1
R2148	T7444	T7445	amod	considerable,apoptosis
R2149	T7445	T7443	pobj	apoptosis,in
R2150	T7446	T7445	compound	RTC,apoptosis
R2153	T7447	T7437	punct	", ",results
R2155	T7448	T7437	advcl	eliminating,results
R2160	T7449	T7450	amod	most,cells
R2189	T7683	T7682	cc	and,BrdU
R2190	T7684	T7685	amod	terminal,labelling
R2192	T7685	T7682	conj	labelling,BrdU
R2193	T7686	T7685	compound	dUTP,labelling
R2195	T7687	T7685	compound	nick,labelling
R2196	T7688	T7685	punct	-,labelling
R2197	T7689	T7685	compound	end,labelling
R2199	T7690	T7685	punct	(,labelling
R2200	T7691	T7685	appos	TUNEL,labelling
R2202	T7692	T7681	punct	),analyses
R2203	T7693	T7678	punct	", ",reversed
R2205	T7694	T7695	compound	E2f1,deletion
R2206	T7695	T7678	nsubj	deletion,reversed
R2207	T7696	T7678	advmod	specifically,reversed
R2209	T7697	T7698	predet	all,defects
R2211	T7698	T7678	dobj	defects,reversed
R2213	T7699	T7698	det	these,defects
R2215	T7700	T7698	amod	molecular,defects
R2216	T7701	T7678	punct	", ",reversed
R2217	T7702	T7678	cc	but,reversed
R2219	T7703	T7704	compound	E2f3,deletion
R2220	T7704	T7705	nsubj	deletion,had
R2221	T7705	T7678	conj	had,reversed
R2223	T7706	T7707	det	no,effect
R2224	T7707	T7705	dobj	effect,had
R2226	T7708	T7709	punct	(,1H
R2227	T7709	T7705	parataxis	1H,had
R2229	T7710	T7709	compound	Figure,1H
R2230	T7711	T7709	punct	),1H
R2231	T7712	T7705	punct	.,had
R2233	T7613	T7607	conj	genes,targets
R2234	T7614	T7615	dep	that,regulate
R2235	T7615	T7613	relcl	regulate,genes
R2236	T7616	T7617	det	the,cycle
R2237	T7617	T7615	dobj	cycle,regulate
R2238	T7618	T7617	compound	cell,cycle
R2239	T7619	T7617	cc	and,cycle
R2240	T7620	T7617	conj	apoptosis,cycle
R2241	T7621	T7590	punct	.,assessed
R2242	T7623	T7624	amod	Numerous,cycle
R2243	T7624	T7629	nsubjpass	cycle,regulated
R2244	T7625	T7624	amod	positive,cycle
R2245	T7626	T7625	cc	and,positive
R2246	T7627	T7625	conj	negative,positive
R2247	T7628	T7624	compound	cell,cycle
R2248	T7630	T7624	cc	and,cycle
R2249	T7631	T7632	amod	apoptotic,regulators
R2250	T7632	T7624	conj	regulators,cycle
R2251	T7633	T7629	auxpass	were,regulated
R2252	T7634	T7629	advmod	up,regulated
R2253	T7635	T7629	punct	-,regulated
R2254	T7636	T7629	prep	in,regulated
R2255	T7637	T7638	det	the,retina
R2256	T7638	T7636	pobj	retina,in
R2257	T7639	T7640	compound	Rb,KO
R2258	T7640	T7638	compound	KO,retina
R2259	T7641	T7642	punct	(,1H
R2260	T7642	T7629	parataxis	1H,regulated
R2261	T7643	T7642	compound	Figure,1H
R2262	T7644	T7642	punct	),1H
R2263	T7645	T7629	punct	.,regulated
R2264	T7647	T7648	prep	Among,induced
R2265	T7649	T7650	det	the,family
R2266	T7650	T7647	pobj	family,Among
R2267	T7651	T7650	compound	E2f,family
R2268	T7652	T7648	punct	", ",induced
R2269	T7653	T7648	nsubjpass	E2f1,induced
R2270	T7654	T7653	punct	", ",E2f1
R2271	T7655	T7653	conj	E2f2,E2f1
R2272	T7656	T7655	punct	", ",E2f2
R2273	T7657	T7655	conj	E2f3a,E2f2
R2274	T7658	T7657	punct	", ",E2f3a
R2275	T7659	T7657	cc	and,E2f3a
R2276	T7660	T7657	conj	E2f7,E2f3a
R2277	T7661	T7648	auxpass	were,induced
R2278	T7662	T7648	prep	following,induced
R2279	T7663	T7664	compound	Rb,loss
R2280	T7664	T7662	pobj	loss,following
R2281	T7665	T7648	punct	", ",induced
R2282	T7666	T7648	cc	but,induced
R2283	T7667	T7668	nsubj	E2f3b,were
R2284	T7668	T7648	conj	were,induced
R2285	T7669	T7667	punct	", ",E2f3b
R2286	T7670	T7667	conj	E2f4,E2f3b
R2287	T7671	T7670	punct	", ",E2f4
R2288	T7672	T7670	cc	and,E2f4
R2289	T7673	T7670	conj	E2f5,E2f4
R2290	T7674	T7668	acomp	unaffected,were
R2291	T7675	T7668	punct	.,were
R2292	T7677	T7678	advcl	Consistent,reversed
R2293	T7679	T7677	prep	with,Consistent
R2294	T7680	T7681	det	the,analyses
R2295	T7681	T7679	pobj	analyses,with
R2296	T7682	T7681	nmod	BrdU,analyses
R10316	T34416	T34417	compound	E2f1,Deletion
R10317	T34417	T34418	nsubj	Deletion,Rescues
R10318	T34419	T34420	nmod	Ganglion,Cells
R10319	T34420	T34418	dobj	Cells,Rescues
R10320	T34421	T34419	punct	", ",Ganglion
R10321	T34422	T34419	conj	Rod,Ganglion
R10322	T34423	T34422	punct	", ",Rod
R10323	T34424	T34422	cc	and,Rod
R10324	T34425	T34422	conj	Bipolar,Rod
R10325	T34426	T34418	prep	in,Rescues
R10326	T34427	T34428	det	the,Retina
R10327	T34428	T34426	pobj	Retina,in
R10328	T34429	T34430	compound	Rb,KO
R10329	T34430	T34428	compound	KO,Retina
R10330	T34432	T34433	punct	(,A
R10331	T34433	T34434	meta	A,stained
R10332	T34435	T34433	punct	),A
R10333	T34436	T34437	amod	Horizontal,sections
R10334	T34437	T34434	nsubjpass	sections,stained
R10335	T34438	T34437	amod	retinal,sections
R10336	T34439	T34437	prep	from,sections
R10337	T34440	T34439	pobj	mice,from
R10338	T34441	T34440	prep	of,mice
R10339	T34442	T34443	det	the,ages
R10340	T34443	T34441	pobj	ages,of
R10341	T34444	T34443	amod	indicated,ages
R10342	T34445	T34443	cc	and,ages
R10343	T34446	T34443	conj	genotypes,ages
R10344	T34447	T34434	auxpass	were,stained
R10345	T34448	T34434	prep	for,stained
R10346	T34449	T34448	pobj	nuclei,for
R10347	T34450	T34451	punct	(,blue
R10348	T34451	T34449	parataxis	blue,nuclei
R10349	T34452	T34451	dep	DAPI,blue
R10350	T34453	T34451	punct	", ",blue
R10351	T34454	T34451	punct	),blue
R10352	T34455	T34449	cc	and,nuclei
R10353	T34456	T34449	conj	markers,nuclei
R10354	T34457	T34458	dep	that,detect
R10355	T34458	T34456	relcl	detect,markers
R10356	T34459	T34460	compound	ganglion,cells
R10357	T34460	T34458	dobj	cells,detect
R10358	T34461	T34462	punct	(,red
R10359	T34462	T34460	parataxis	red,cells
R10360	T34463	T34462	dep	Pou4f2,red
R10361	T34464	T34462	punct	", ",red
R10362	T34465	T34462	punct	),red
R10363	T34466	T34460	punct	", ",cells
R10364	T34467	T34460	conj	rods,cells
R10365	T34468	T34467	cc	and,rods
R10366	T34469	T34467	conj	cones,rods
R10367	T34470	T34471	punct	(,green
R10368	T34471	T34469	parataxis	green,cones
R10369	T34472	T34471	dep	Sag,green
R10370	T34473	T34471	punct	[,green
R10371	T34474	T34475	compound	rod,arrestin
R10372	T34475	T34471	dep	arrestin,green
R10373	T34476	T34471	punct	],green
R10374	T34477	T34471	punct	", ",green
R10375	T34478	T34471	punct	),green
R10376	T34479	T34467	punct	", ",rods
R10377	T34480	T34467	cc	and,rods
R10378	T34481	T34482	nmod	rod,cells
R10379	T34482	T34467	conj	cells,rods
R10380	T34483	T34482	amod	bipolar,cells
R10381	T34484	T34485	punct	(,green
R10382	T34485	T34482	parataxis	green,cells
R10383	T34486	T34485	dep	Prkca,green
R10384	T34487	T34485	punct	", ",green
R10385	T34488	T34485	punct	", ",green
R10386	T34489	T34485	cc	and,green
R10387	T34490	T34491	dep	Cabp5,red
R10388	T34491	T34485	conj	red,green
R10389	T34492	T34491	punct	", ",red
R10390	T34493	T34491	punct	),red
R10391	T34494	T34434	punct	.,stained
R10392	T34496	T34497	compound	Scale,bars
R10393	T34497	T34498	nsubj	bars,are
R10394	T34499	T34500	nummod	50,μm
R10395	T34500	T34498	attr	μm,are
R10396	T34501	T34498	punct	.,are
R10397	T34503	T34504	punct	(,B
R10398	T34504	T34505	meta	B,Quantification
R10399	T34506	T34504	punct	),B
R10400	T34507	T34505	prep	of,Quantification
R10401	T34508	T34509	nmod	Pou4f2,cells
R10402	T34509	T34507	pobj	cells,of
R10403	T34510	T34508	punct	+,Pou4f2
R10404	T34511	T34509	compound	ganglion,cells
R10405	T34512	T34505	punct	.,Quantification
R10406	T34514	T34515	punct	(,C
R10407	T34515	T34516	meta	C,Quantification
R10408	T34517	T34515	punct	),C
R10409	T34518	T34516	prep	of,Quantification
R10410	T34519	T34520	nmod	Prkca,cells
R10411	T34520	T34518	pobj	cells,of
R10412	T34521	T34519	punct	+,Prkca
R10413	T34522	T34519	cc	and,Prkca
R10414	T34523	T34519	conj	Cabp5,Prkca
R10415	T34524	T34523	punct	+,Cabp5
R10416	T34525	T34520	amod	bipolar,cells
R10417	T34526	T34516	punct	.,Quantification
R10418	T34528	T34529	punct	(,D
R10419	T34529	T34530	meta	D,Thickness
R10420	T34531	T34529	punct	),D
R10421	T34532	T34530	prep	of,Thickness
R10422	T34533	T34534	det	the,ONL
R10423	T34534	T34532	pobj	ONL,of
R10424	T34535	T34534	punct	", ",ONL
R10425	T34536	T34537	dep	which,represents
R10426	T34537	T34534	relcl	represents,ONL
R10427	T34538	T34539	det	the,number
R10428	T34539	T34537	dobj	number,represents
R10429	T34540	T34539	prep	of,number
R10430	T34541	T34540	pobj	rods,of
R10431	T34542	T34530	punct	.,Thickness
R10432	T34544	T34545	compound	Error,bars
R10433	T34545	T34546	nsubj	bars,represent
R10434	T34547	T34546	dobj	SD,represent
R10435	T34548	T34547	prep	of,SD
R10436	T34549	T34548	pobj	measurements,of
R10437	T34550	T34549	prep	from,measurements
R10438	T34551	T34552	nummod	three,animals
R10439	T34552	T34550	pobj	animals,from
R10440	T34553	T34546	punct	", ",represent
R10441	T34554	T34546	cc	and,represent
R10442	T34555	T34556	nsubj	asterisks,indicate
R10443	T34556	T34546	conj	indicate,represent
R10444	T34557	T34558	det	a,difference
R10445	T34558	T34556	dobj	difference,indicate
R10446	T34559	T34558	amod	significant,difference
R10447	T34560	T34558	prep	between,difference
R10448	T34561	T34560	pobj	retinas,between
R10449	T34562	T34561	prep	of,retinas
R10450	T34563	T34562	pobj	WT,of
R10451	T34564	T34563	cc	and,WT
R10452	T34565	T34566	det	the,indicated
R10453	T34566	T34567	nmod	indicated,genotypes
R10454	T34567	T34563	conj	genotypes,WT
R10455	T34568	T34556	punct	", ",indicate
R10456	T34569	T34570	mark	unless,indicated
R10457	T34570	T34556	advcl	indicated,indicate
R10458	T34571	T34570	advmod	otherwise,indicated
R10459	T34572	T34570	agent	by,indicated
R10460	T34573	T34574	amod	connecting,lines
R10461	T34574	T34572	pobj	lines,by
R10462	T34575	T34576	punct	(,test
R10463	T34576	T34556	parataxis	test,indicate
R10464	T34577	T34578	punct	*,0.05
R10465	T34578	T34576	ccomp	0.05,test
R10466	T34579	T34578	punct	", ",0.05
R10467	T34580	T34578	nsubj	p,0.05
R10468	T34581	T34578	punct	<,0.05
R10469	T34582	T34576	punct	;,test
R10470	T34583	T34584	punct	**,0.01
R10471	T34584	T34576	ccomp	0.01,test
R10472	T34585	T34584	punct	;,0.01
R10473	T34586	T34584	nsubj	p,0.01
R10474	T34587	T34584	punct	<,0.01
R10475	T34588	T34576	punct	;,test
R10476	T34589	T34576	nmod	ANOVA,test
R10477	T34590	T34589	cc	and,ANOVA
R10478	T34591	T34592	compound	Tukey,HSD
R10479	T34592	T34589	conj	HSD,ANOVA
R10480	T34593	T34576	punct	),test
R10481	T34594	T34556	punct	.,indicate
R10482	T34596	T34597	punct	(,E
R10483	T34597	T34598	meta	E,recorded
R10484	T34599	T34597	cc	and,E
R10485	T34600	T34597	conj	F,E
R10486	T34601	T34600	punct	),F
R10487	T34602	T34598	nsubjpass	ERGs,recorded
R10488	T34603	T34598	auxpass	were,recorded
R10489	T34604	T34598	prep	from,recorded
R10490	T34605	T34606	det	the,genotypes
R10491	T34606	T34604	pobj	genotypes,from
R10492	T34607	T34606	amod	indicated,genotypes
R10493	T34608	T34598	prep	under,recorded
R10494	T34609	T34610	npadvmod	dark,adapted
R10495	T34610	T34612	amod	adapted,conditions
R10496	T34611	T34610	punct	-,adapted
R10497	T34612	T34608	pobj	conditions,under
R10498	T34613	T34614	punct	(,scotopic
R10499	T34614	T34610	parataxis	scotopic,adapted
R10500	T34615	T34614	punct	),scotopic
R10501	T34616	T34598	punct	", ",recorded
R10502	T34617	T34598	cc	and,recorded
R10503	T34618	T34619	punct	(,E
R10504	T34619	T34620	parataxis	E,series
R10505	T34620	T34623	nsubjpass	series,determined
R10506	T34621	T34619	punct	),E
R10507	T34622	T34620	compound	intensity,series
R10508	T34623	T34598	conj	determined,recorded
R10509	T34624	T34620	cc	and,series
R10510	T34625	T34626	punct	(,F
R10511	T34626	T34627	parataxis	F,amplitudes
R10512	T34627	T34620	conj	amplitudes,series
R10513	T34628	T34626	punct	),F
R10514	T34629	T34630	compound	b,wave
R10515	T34630	T34627	compound	wave,amplitudes
R10516	T34631	T34630	punct	-,wave
R10517	T34632	T34620	prep	as,series
R10518	T34633	T34634	det	a,function
R10519	T34634	T34632	pobj	function,as
R10520	T34635	T34634	prep	of,function
R10521	T34636	T34637	det	the,logarithm
R10522	T34637	T34635	pobj	logarithm,of
R10523	T34638	T34637	prep	of,logarithm
R10524	T34639	T34640	det	the,intensity
R10525	T34640	T34638	pobj	intensity,of
R10526	T34641	T34640	compound	flash,intensity
R10527	T34642	T34623	auxpass	were,determined
R10528	T34643	T34623	punct	.,determined
R10529	T34645	T34646	punct	(,illustrates
R10530	T34647	T34646	nsubj	F,illustrates
R10531	T34648	T34646	punct	),illustrates
R10532	T34649	T34646	advmod	Further,illustrates
R10533	T34650	T34651	mark	that,was
R10534	T34651	T34646	ccomp	was,illustrates
R10535	T34652	T34653	det	the,influence
R10536	T34653	T34651	nsubj	influence,was
R10537	T34654	T34653	amod	relative,influence
R10538	T34655	T34653	prep	of,influence
R10539	T34656	T34657	det	the,mutations
R10540	T34657	T34655	pobj	mutations,of
R10541	T34658	T34653	prep	on,influence
R10542	T34659	T34660	det	the,photoreceptors
R10543	T34660	T34658	pobj	photoreceptors,on
R10544	T34661	T34660	punct	(,photoreceptors
R10545	T34662	T34660	acl	indicated,photoreceptors
R10546	T34663	T34662	agent	by,indicated
R10547	T34664	T34665	det	the,amplitude
R10548	T34665	T34663	pobj	amplitude,by
R10549	T34666	T34665	amod	saturated,amplitude
R10550	T34667	T34668	compound	a,wave
R10551	T34668	T34665	compound	wave,amplitude
R10552	T34669	T34668	punct	-,wave
R10553	T34670	T34671	punct	", ",graph
R10554	T34671	T34662	parataxis	graph,indicated
R10555	T34672	T34671	amod	right,graph
R10556	T34673	T34671	punct	),graph
R10557	T34674	T34651	neg	not,was
R10558	T34675	T34676	advmod	substantially,different
R10559	T34676	T34651	acomp	different,was
R10560	T34677	T34676	prep	from,different
R10561	T34678	T34679	poss	their,effect
R10562	T34679	T34677	pobj	effect,from
R10563	T34680	T34679	prep	on,effect
R10564	T34681	T34682	det	the,response
R10565	T34682	T34680	pobj	response,on
R10566	T34683	T34684	compound	b,wave
R10567	T34684	T34682	compound	wave,response
R10568	T34685	T34684	punct	-,wave
R10569	T34686	T34679	punct	(,effect
R10570	T34687	T34679	acl	dominated,effect
R10571	T34688	T34687	agent	by,dominated
R10572	T34689	T34690	det	the,bipolars
R10573	T34690	T34688	pobj	bipolars,by
R10574	T34691	T34692	punct	", ",graph
R10575	T34692	T34690	parataxis	graph,bipolars
R10576	T34693	T34692	amod	left,graph
R10577	T34694	T34692	punct	),graph
R10578	T34695	T34690	prep	at,bipolars
R10579	T34696	T34697	det	the,intensity
R10580	T34697	T34695	pobj	intensity,at
R10581	T34698	T34697	amod	same,intensity
R10582	T34699	T34697	prep	of,intensity
R10583	T34700	T34701	nummod	10,s
R10584	T34701	T34699	pobj	s,of
R10585	T34702	T34701	nmod	cd,s
R10586	T34703	T34701	punct	·,s
R10587	T34704	T34705	punct	/,m2
R10588	T34705	T34701	prep	m2,s
R10589	T34706	T34646	punct	.,illustrates
R2151	T7562	T7561	neg	not,but
R2152	T7563	T7559	conj	E2f2,E2f1
R2154	T7564	T7563	cc	or,E2f2
R2156	T7565	T7563	conj	E2f3,E2f2
R2157	T7566	T7558	punct	", ",blocked
R2158	T7567	T7568	det	this,death
R2159	T7568	T7558	dobj	death,blocked
R2161	T7569	T7568	amod	ectopic,death
R2162	T7570	T7568	compound	cell,death
R2164	T7571	T7558	prep	in,blocked
R2165	T7572	T7573	det	a,fashion
R2166	T7573	T7571	pobj	fashion,in
R2167	T7574	T7575	npadvmod	dose,dependent
R2168	T7575	T7573	amod	dependent,fashion
R2170	T7576	T7575	punct	-,dependent
R2171	T7577	T7578	punct	(,1D
R2173	T7578	T7558	parataxis	1D,blocked
R2174	T7579	T7578	compound	Figures,1D
R2175	T7580	T7578	punct	", ",1D
R2176	T7581	T7578	conj	1G,1D
R2178	T7582	T7581	punct	", ",1G
R2179	T7583	T7581	cc	and,1G
R2180	T7584	T7581	conj	S1B,1G
R2182	T7585	T7578	punct	),1D
R2183	T7586	T7558	punct	.,blocked
R2163	T7588	T7589	aux	To,investigate
R2169	T7589	T7590	advcl	investigate,assessed
R2172	T7591	T7592	det	the,mechanism
R2177	T7592	T7589	dobj	mechanism,investigate
R2181	T7593	T7592	amod	molecular,mechanism
R2184	T7594	T7595	dep	that,underlies
R2185	T7595	T7592	relcl	underlies,mechanism
R2186	T7596	T7597	det	the,role
R2187	T7597	T7595	dobj	role,underlies
R2188	T7598	T7597	amod	unique,role
R2191	T7599	T7597	prep	of,role
R2194	T7600	T7599	pobj	E2f1,of
R2198	T7601	T7590	punct	", ",assessed
R2201	T7602	T7590	nsubj	we,assessed
R2204	T7603	T7604	det	the,expression
R2208	T7604	T7590	dobj	expression,assessed
R2210	T7605	T7604	prep	of,expression
R2212	T7606	T7607	amod	known,targets
R2214	T7607	T7605	pobj	targets,of
R2218	T7608	T7607	compound	E2f,targets
R2222	T7609	T7610	advmod	as,as
R2225	T7610	T7607	cc	as,targets
R2228	T7611	T7610	advmod	well,as
R2232	T7612	T7613	amod	other,genes

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T6707	0-2	PR_EXT:000013773	denotes	Rb
T6708	3-12	GO:0065007	denotes	Regulates
T6709	26-31	GO:0016265	denotes	Death
T6710	40-44	PR_EXT:000006852	denotes	E2f1
T6711	63-72	SO_EXT:0000902	denotes	transgene
T6712	76-82	SO_EXT:sequence_deletion_process	denotes	delete
T6713	83-89	SO:0000359	denotes	floxed
T6714	90-92	PR_EXT:000013773	denotes	Rb
T6715	93-97	SO_EXT:0000147	denotes	exon
T6716	104-113	UBERON:0000922	denotes	embryonic
T6717	128-145	UBERON:0013682	denotes	peripheral retina
T6718	151-153	PR_EXT:000013773	denotes	Rb
T6719	153-157	SO_EXT:0000346	denotes	loxP
T6720	158-162	SO_EXT:0000346	denotes	loxP
T6721	169-173	NCBITaxon:10088	denotes	mice
T6722	179-183	GO_EXT:breeding	denotes	bred
T6723	205-209	PR_EXT:000006852	denotes	E2f1
T6724	213-217	PR_EXT:000006853	denotes	E2f2
T6725	259-265	SO:0000359	denotes	floxed
T6726	266-270	PR_EXT:000006854	denotes	E2f3
T6727	271-277	SO_EXT:0001023	denotes	allele
T6728	283-285	PR_EXT:000013773	denotes	Rb
T6729	285-289	SO_EXT:0000346	denotes	loxP
T6730	290-294	SO_EXT:0000346	denotes	loxP
T6731	295-299	PR_EXT:000006852	denotes	E2f1
T6732	299-300	SO_EXT:normal_or_wild_type_or_present	denotes	+
T6733	301-302	SO_EXT:sequence_nullness_or_absence	denotes	−
T6734	307-309	PR_EXT:000013773	denotes	Rb
T6735	309-313	SO_EXT:0000346	denotes	loxP
T6736	314-318	SO_EXT:0000346	denotes	loxP
T6737	319-323	PR_EXT:000006852	denotes	E2f1
T6738	323-324	SO_EXT:normal_or_wild_type_or_present	denotes	+
T6739	325-326	SO_EXT:sequence_nullness_or_absence	denotes	−
T6740	333-337	NCBITaxon:10088	denotes	mice
T6741	343-347	GO_EXT:breeding	denotes	bred
T6742	359-361	PR_EXT:000013773	denotes	Rb
T6743	361-365	SO_EXT:0000346	denotes	loxP
T6744	366-370	SO_EXT:0000346	denotes	loxP
T6745	371-375	PR_EXT:000006852	denotes	E2f1
T6746	375-376	SO_EXT:sequence_nullness_or_absence	denotes	−
T6747	377-378	SO_EXT:sequence_nullness_or_absence	denotes	−
T6748	385-389	NCBITaxon:10088	denotes	mice
T6749	511-513	PR_EXT:000013773	denotes	Rb
T6750	513-517	SO_EXT:0000346	denotes	loxP
T6751	518-522	SO_EXT:0000346	denotes	loxP
T6752	523-527	PR_EXT:000006852	denotes	E2f1
T6753	527-528	SO_EXT:sequence_nullness_or_absence	denotes	−
T6754	529-530	SO_EXT:sequence_nullness_or_absence	denotes	−
T6755	537-554	UBERON:0013682	denotes	peripheral retina
T6756	562-564	PR_EXT:000013773	denotes	Rb
T6757	565-569	PR_EXT:000006852	denotes	E2f1
T6758	592-598	UBERON:0000966	denotes	retina
T6759	648-652	PR_EXT:000006853	denotes	E2f2
T6760	656-660	PR_EXT:000006854	denotes	E2f3
T6761	675-683	SO_EXT:sequence_deletion_process	denotes	excision
T6762	687-689	PR_EXT:000013773	denotes	Rb
T6763	694-698	PR_EXT:000006854	denotes	E2f3
T6764	699-706	SO_EXT:0001023	denotes	alleles
T6765	714-720	UBERON:0000966	denotes	retina
T6766	792-796	CL_GO_EXT:cell	denotes	cell
T6767	792-805	GO:0051301	denotes	cell division
T6768	807-811	NCBITaxon:10088	denotes	mice
T6769	823-831	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T6770	837-854	CHEBI:472552	denotes	bromodeoxyuridine
T6771	856-860	CHEBI:472552	denotes	BrdU
T6772	873-882	GO_EXT:killing	denotes	sacrifice
T6773	891-908	UBERON:0013682	denotes	peripheral retina
T6774	922-926	CHEBI:472552	denotes	BrdU
T6775	990-992	PR_EXT:000013773	denotes	Rb
T6776	996-1003	UBERON:0000966	denotes	retinas
T6777	1048-1051	CHEBI_SO_EXT:DNA	denotes	DNA
T6778	1048-1061	GO:0071897	denotes	DNA synthesis
T6779	1129-1134	GO:0007567	denotes	natal
T6780	1158-1164	UBERON:0000966	denotes	retina
T6781	1180-1184	CHEBI:472552	denotes	BrdU
T6795	1644-1648	PR_EXT:000006852	denotes	E2f1
T6796	1653-1659	UBERON:0000966	denotes	retina
T6797	1708-1716	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T6798	1720-1724	PR_EXT:000006853	denotes	E2f2
T6799	1728-1732	PR_EXT:000006854	denotes	E2f3
T6800	1788-1795	GO:0007067	denotes	mitotic
T6801	1796-1801	CL_GO_EXT:cell	denotes	cells
T6802	1812-1826	CHEBI_EXT:phosphohistone	denotes	phosphohistone
T6803	1844-1854	GO:0042571	denotes	antibodies
T6804	1878-1882	PR_EXT:000006852	denotes	E2f1
T6805	1892-1896	PR_EXT:000006853	denotes	E2f2
T6806	1900-1904	PR_EXT:000006854	denotes	E2f3
T6807	1947-1955	SO_EXT:sequence_deletion_process	denotes	Deleting
T6808	1960-1964	PR_EXT:000006852	denotes	E2f1
T6809	1965-1971	SO_EXT:0001023	denotes	allele
T6810	2001-2008	GO:0051320	denotes	S-phase
T6811	2013-2020	GO:0007067	denotes	mitosis
T6812	2024-2026	PR_EXT:000013773	denotes	Rb
T6813	2090-2094	PR_EXT:000006852	denotes	E2f1
T6814	2122-2124	PR_EXT:000013773	denotes	Rb
T6815	2212-2216	UBERON_EXT:lens	denotes	lens
T6816	2221-2224	UBERON:0001017	denotes	CNS
T6817	2228-2230	PR_EXT:000013773	denotes	Rb
T6818	2234-2241	UBERON:0000922	denotes	embryos
T6819	2249-2257	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T6820	2276-2279	PR_EXT:E2F	denotes	E2f
T6821	2338-2340	PR_EXT:000013773	denotes	Rb
T6822	2348-2354	UBERON:0000966	denotes	retina
T6823	2383-2392	GO:0006915	denotes	apoptosis
T6824	2394-2405	GO_EXT:killing	denotes	eliminating
T6825	2411-2418	_FRAGMENT	denotes	bipolar
T6826	2432-2437	CL:0000103	denotes	cells
T6827	2423-2431	UBERON:0000045	denotes	ganglion
T6828	2423-2437	CL:0000740	denotes	ganglion cells
T6829	2432-2437	CL_GO_EXT:cell	denotes	cells
T6830	2454-2458	CL:0000604	denotes	rods
T6831	2493-2495	PR_EXT:000013773	denotes	Rb
T6832	2499-2503	CL:0000604	denotes	rods
T6833	2532-2535	UBERON:0001789	denotes	ONL
T6834	2545-2553	_FRAGMENT	denotes	death of
T6835	2560-2565	GO:0008219	denotes	cells
T6836	2560-2565	CL_GO_EXT:cell	denotes	cells
T6837	2577-2584	_FRAGMENT	denotes	bipolar
T6838	2598-2605	CL:0000103	denotes	neurons
T6839	2589-2597	UBERON:0000045	denotes	ganglion
T6840	2589-2605	CL:0000740	denotes	ganglion neurons
T6841	2641-2650	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelling
T6842	2655-2664	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T6843	2669-2673	CL_GO_EXT:cell	denotes	cell
T6844	2688-2695	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T6845	2756-2758	PR_EXT:000013773	denotes	Rb
T6846	2762-2770	UBERON:0000045	denotes	ganglion
T6847	2762-2776	CL:0000740	denotes	ganglion cells
T6848	2771-2776	CL_GO_EXT:cell	denotes	cells
T6849	2814-2825	UBERON_EXT:optic_nerve	denotes	optic nerve
T6850	2863-2871	SO_EXT:sequence_deletion_process	denotes	Deleting
T6851	2872-2876	PR_EXT:000006852	denotes	E2f1
T6852	2886-2890	PR_EXT:000006853	denotes	E2f2
T6853	2894-2898	PR_EXT:000006854	denotes	E2f3
T6854	2921-2925	CL_GO_EXT:cell	denotes	cell
T6855	2921-2931	GO:0008219	denotes	cell death
T34375	3065-3071	UBERON:0000966	denotes	Retina
T34376	3087-3094	UBERON:0000966	denotes	retinal
T34377	3109-3113	NCBITaxon:10088	denotes	mice
T34364	2997-3001	PR_EXT:000006852	denotes	E2f1
T34365	3002-3010	SO_EXT:sequence_deletion_entity_or_process	denotes	Deletion
T34366	3011-3018	SO_EXT:sequence_rescue_process	denotes	Rescues
T34367	3019-3027	UBERON:0000045	denotes	Ganglion
T34368	3019-3027	_FRAGMENT	denotes	Ganglion
T34369	3046-3051	CL:0000740	denotes	Cells
T34370	3029-3032	_FRAGMENT	denotes	Rod
T34371	3046-3051	CL:0000604	denotes	Cells
T34372	3038-3051	CL:0000748	denotes	Bipolar Cells
T34373	3046-3051	CL_GO_EXT:cell	denotes	Cells
T34374	3059-3061	PR_EXT:000013773	denotes	Rb
T34378	3140-3149	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T34379	3167-3173	GO:0005634	denotes	nuclei
T34380	3175-3179	CHEBI:51231	denotes	DAPI
T34381	3191-3198	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T34382	3211-3219	UBERON:0000045	denotes	ganglion
T34383	3211-3225	CL:0000740	denotes	ganglion cells
T34384	3220-3225	CL_GO_EXT:cell	denotes	cells
T34385	3227-3233	PR_EXT:000013042	denotes	Pou4f2
T34386	3241-3245	CL:0000604	denotes	rods
T34387	3250-3255	CL:0000573	denotes	cones
T34388	3257-3260	PR_EXT:000014434	denotes	Sag
T34389	3262-3265	CL:0000604	denotes	rod
T34390	3262-3274	PR_EXT:000014434	denotes	rod arrestin
T34391	3289-3306	CL:0000751	denotes	rod bipolar cells
T34392	3301-3306	CL_GO_EXT:cell	denotes	cells
T34393	3308-3313	PR_EXT:000003058	denotes	Prkca
T34394	3326-3331	PR_EXT:000004937	denotes	Cabp5
T34395	3383-3389	PR_EXT:000013042	denotes	Pou4f2
T34396	3391-3399	UBERON:0000045	denotes	ganglion
T34397	3391-3405	CL:0000740	denotes	ganglion cells
T34398	3400-3405	CL_GO_EXT:cell	denotes	cells
T34399	3429-3434	PR_EXT:000003058	denotes	Prkca
T34400	3440-3445	PR_EXT:000004937	denotes	Cabp5
T34401	3447-3460	CL:0000103	denotes	bipolar cells
T34402	3455-3460	CL_GO_EXT:cell	denotes	cells
T34403	3483-3486	UBERON:0001789	denotes	ONL
T34404	3519-3523	CL:0000604	denotes	rods
T34405	3576-3583	NCBITaxon:33208	denotes	animals
T34406	3641-3648	UBERON:0000966	denotes	retinas
T34407	3652-3654	SO_EXT:wild_type_entity_or_quality	denotes	WT
T34408	3673-3682	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T34409	3834-3843	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T34410	3850-3862	GO:1990603	denotes	dark-adapted
T34411	3864-3872	GO:1990603	denotes	scotopic
T34412	4067-4076	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T34413	4084-4098	CL:0000210	denotes	photoreceptors
T34414	4222-4230	GO_EXT:reaction_or_response	denotes	response
T34415	4249-4257	CL:0000103	denotes	bipolars
T6782	1186-1194	UBERON:0000045	denotes	ganglion
T6783	1199-1207	CL:0000561	denotes	amacrine
T6784	1263-1269	UBERON:0000966	denotes	retina
T6785	1277-1281	CHEBI:472552	denotes	BrdU
T6786	1283-1296	CL:0000210	denotes	photoreceptor
T6787	1367-1369	PR_EXT:000013773	denotes	Rb
T6788	1373-1380	UBERON:0000966	denotes	retinas
T6789	1446-1455	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T6790	1457-1459	SO_EXT:wild_type_entity_or_quality	denotes	WT
T6791	1461-1467	UBERON:0000966	denotes	retina
T6792	1529-1536	GO:0051320	denotes	S-phase
T6793	1537-1542	CL_GO_EXT:cell	denotes	cells
T6794	1641-1643	PR_EXT:000013773	denotes	Rb
T6856	4327-4336	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T6857	4381-4385	PR_EXT:000006852	denotes	E2f1
T6858	4403-4413	GO:0010467	denotes	expression
T6859	4423-4426	PR_EXT:E2F	denotes	E2f
T6860	4452-4457	SO_EXT:0000704	denotes	genes
T6861	4463-4471	GO:0065007	denotes	regulate
T6862	4476-4480	CL_GO_EXT:cell	denotes	cell
T6863	4476-4486	GO:0007049	denotes	cell cycle
T6864	4491-4500	GO:0006915	denotes	apoptosis
T6865	4533-4537	CL_GO_EXT:cell	denotes	cell
T6866	4533-4543	GO:0007049	denotes	cell cycle
T6867	4548-4557	GO_PATO_EXT:apoptotic_process_or_quality	denotes	apoptotic
T6868	4558-4568	GO_EXT:regulator	denotes	regulators
T6869	4574-4586	GO_EXT:positive_regulation	denotes	up-regulated
T6870	4594-4596	PR_EXT:000013773	denotes	Rb
T6871	4600-4606	UBERON:0000966	denotes	retina
T6872	4630-4633	PR_EXT:E2F	denotes	E2f
T6873	4642-4646	PR_EXT:000006852	denotes	E2f1
T6874	4648-4652	PR_EXT:000006853	denotes	E2f2
T6875	4654-4659	PR_EXT:000028775	denotes	E2f3a
T6876	4665-4669	PR_EXT:000006858	denotes	E2f7
T6877	4693-4695	PR_EXT:000013773	denotes	Rb
T6878	4713-4717	PR_EXT:000006855	denotes	E2f4
T6879	4723-4727	PR_EXT:000006856	denotes	E2f5
T6880	4765-4769	CHEBI:472552	denotes	BrdU
T6881	4783-4787	CHEBI_EXT:dUTP	denotes	dUTP
T6882	4797-4806	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelling
T6883	4825-4829	PR_EXT:000006852	denotes	E2f1
T6884	4830-4838	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T6885	4871-4880	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T6886	4894-4898	PR_EXT:000006854	denotes	E2f3
T6887	4899-4907	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
R10314	T34369	T34368	_lexicallyChainedTo	Cells,Ganglion
R10315	T34371	T34370	_lexicallyChainedTo	Cells,Rod
R1516	T6826	T6825	_lexicallyChainedTo	cells,bipolar
R1517	T6835	T6834	_lexicallyChainedTo	cells,death of
R1518	T6838	T6837	_lexicallyChainedTo	neurons,bipolar

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T6616	648-652	PR:000006853	denotes	E2f2
T6617	656-660	PR:000006854	denotes	E2f3
T6618	687-689	PR:000013773	denotes	Rb
T6619	694-698	PR:000006854	denotes	E2f3
T6620	699-706	SO:0001023	denotes	alleles
T6621	714-720	UBERON:0000966	denotes	retina
T6622	792-805	GO:0051301	denotes	cell division
T6623	807-811	NCBITaxon:10088	denotes	mice
T6624	837-854	CHEBI:472552	denotes	bromodeoxyuridine
T6625	856-860	CHEBI:472552	denotes	BrdU
T6626	891-908	UBERON:0013682	denotes	peripheral retina
T6627	922-926	CHEBI:472552	denotes	BrdU
T6628	990-992	PR:000013773	denotes	Rb
T6575	0-2	PR:000013773	denotes	Rb
T6576	3-12	GO:0065007	denotes	Regulates
T6577	26-31	GO:0016265	denotes	Death
T6578	40-44	PR:000006852	denotes	E2f1
T6579	63-72	SO:0000902	denotes	transgene
T6580	83-89	SO:0000359	denotes	floxed
T6581	90-92	PR:000013773	denotes	Rb
T6582	93-97	SO:0000147	denotes	exon
T6583	104-113	UBERON:0000922	denotes	embryonic
T6584	128-145	UBERON:0013682	denotes	peripheral retina
T6585	151-153	PR:000013773	denotes	Rb
T6586	153-157	SO:0000346	denotes	loxP
T6587	158-162	SO:0000346	denotes	loxP
T6588	169-173	NCBITaxon:10088	denotes	mice
T6589	205-209	PR:000006852	denotes	E2f1
T6590	213-217	PR:000006853	denotes	E2f2
T6591	259-265	SO:0000359	denotes	floxed
T6592	266-270	PR:000006854	denotes	E2f3
T6593	271-277	SO:0001023	denotes	allele
T6594	283-285	PR:000013773	denotes	Rb
T6595	285-289	SO:0000346	denotes	loxP
T6596	290-294	SO:0000346	denotes	loxP
T6597	295-299	PR:000006852	denotes	E2f1
T6598	307-309	PR:000013773	denotes	Rb
T6599	309-313	SO:0000346	denotes	loxP
T6600	314-318	SO:0000346	denotes	loxP
T6601	319-323	PR:000006852	denotes	E2f1
T6602	333-337	NCBITaxon:10088	denotes	mice
T6603	359-361	PR:000013773	denotes	Rb
T6604	361-365	SO:0000346	denotes	loxP
T6605	366-370	SO:0000346	denotes	loxP
T6606	371-375	PR:000006852	denotes	E2f1
T6607	385-389	NCBITaxon:10088	denotes	mice
T6608	511-513	PR:000013773	denotes	Rb
T6609	513-517	SO:0000346	denotes	loxP
T6610	518-522	SO:0000346	denotes	loxP
T6611	523-527	PR:000006852	denotes	E2f1
T6612	537-554	UBERON:0013682	denotes	peripheral retina
T6613	562-564	PR:000013773	denotes	Rb
T6614	565-569	PR:000006852	denotes	E2f1
T6615	592-598	UBERON:0000966	denotes	retina
T6629	996-1003	UBERON:0000966	denotes	retinas
T6630	1048-1061	GO:0071897	denotes	DNA synthesis
T6631	1129-1134	GO:0007567	denotes	natal
T6632	1158-1164	UBERON:0000966	denotes	retina
T6633	1180-1184	CHEBI:472552	denotes	BrdU
T6670	2454-2458	CL:0000604	denotes	rods
T6671	2493-2495	PR:000013773	denotes	Rb
T6672	2499-2503	CL:0000604	denotes	rods
T6673	2532-2535	UBERON:0001789	denotes	ONL
T6674	2545-2553	_FRAGMENT	denotes	death of
T6675	2560-2565	GO:0008219	denotes	cells
T6676	2577-2584	_FRAGMENT	denotes	bipolar
T6677	2598-2605	CL:0000103	denotes	neurons
T6678	2589-2597	UBERON:0000045	denotes	ganglion
T6679	2589-2605	CL:0000740	denotes	ganglion neurons
T6680	2756-2758	PR:000013773	denotes	Rb
T6681	2762-2770	UBERON:0000045	denotes	ganglion
T6682	2762-2776	CL:0000740	denotes	ganglion cells
T6683	2814-2819	UBERON:0000970	denotes	optic
T6684	2872-2876	PR:000006852	denotes	E2f1
T6685	2886-2890	PR:000006853	denotes	E2f2
T6686	2894-2898	PR:000006854	denotes	E2f3
T6687	2921-2931	GO:0008219	denotes	cell death
T34326	2997-3001	PR:000006852	denotes	E2f1
T34327	3019-3027	UBERON:0000045	denotes	Ganglion
T34328	3019-3027	_FRAGMENT	denotes	Ganglion
T34329	3046-3051	CL:0000740	denotes	Cells
T34330	3029-3032	_FRAGMENT	denotes	Rod
T34331	3046-3051	CL:0000604	denotes	Cells
T34332	3038-3051	CL:0000748	denotes	Bipolar Cells
T34333	3059-3061	PR:000013773	denotes	Rb
T34334	3065-3071	UBERON:0000966	denotes	Retina
T34335	3087-3094	UBERON:0000966	denotes	retinal
T34336	3109-3113	NCBITaxon:10088	denotes	mice
T34337	3167-3173	GO:0005634	denotes	nuclei
T34338	3175-3179	CHEBI:51231	denotes	DAPI
T34339	3211-3219	UBERON:0000045	denotes	ganglion
T34340	3211-3225	CL:0000740	denotes	ganglion cells
T34341	3227-3233	PR:000013042	denotes	Pou4f2
T34342	3241-3245	CL:0000604	denotes	rods
T34343	3250-3255	CL:0000573	denotes	cones
T34344	3257-3260	PR:000014434	denotes	Sag
T34345	3262-3265	CL:0000604	denotes	rod
T34346	3262-3274	PR:000014434	denotes	rod arrestin
T34347	3289-3306	CL:0000751	denotes	rod bipolar cells
T34348	3308-3313	PR:000003058	denotes	Prkca
T34349	3326-3331	PR:000004937	denotes	Cabp5
T34350	3383-3389	PR:000013042	denotes	Pou4f2
T34351	3391-3399	UBERON:0000045	denotes	ganglion
T34352	3391-3405	CL:0000740	denotes	ganglion cells
T34353	3429-3434	PR:000003058	denotes	Prkca
T34354	3440-3445	PR:000004937	denotes	Cabp5
T34355	3447-3460	CL:0000103	denotes	bipolar cells
T34356	3483-3486	UBERON:0001789	denotes	ONL
T34357	3519-3523	CL:0000604	denotes	rods
T34358	3576-3583	NCBITaxon:33208	denotes	animals
T34359	3641-3648	UBERON:0000966	denotes	retinas
T34360	3850-3862	GO:1990603	denotes	dark-adapted
T34361	3864-3872	GO:1990603	denotes	scotopic
T34362	4084-4098	CL:0000210	denotes	photoreceptors
T34363	4249-4257	CL:0000103	denotes	bipolars
T6654	1965-1971	SO:0001023	denotes	allele
T6634	1186-1194	UBERON:0000045	denotes	ganglion
T6635	1199-1207	CL:0000561	denotes	amacrine
T6636	1263-1269	UBERON:0000966	denotes	retina
T6637	1277-1281	CHEBI:472552	denotes	BrdU
T6638	1283-1296	CL:0000210	denotes	photoreceptor
T6639	1367-1369	PR:000013773	denotes	Rb
T6640	1373-1380	UBERON:0000966	denotes	retinas
T6641	1461-1467	UBERON:0000966	denotes	retina
T6642	1529-1536	GO:0051320	denotes	S-phase
T6643	1641-1643	PR:000013773	denotes	Rb
T6644	1644-1648	PR:000006852	denotes	E2f1
T6645	1653-1659	UBERON:0000966	denotes	retina
T6646	1720-1724	PR:000006853	denotes	E2f2
T6647	1728-1732	PR:000006854	denotes	E2f3
T6648	1788-1795	GO:0007067	denotes	mitotic
T6649	1844-1854	GO:0042571	denotes	antibodies
T6650	1878-1882	PR:000006852	denotes	E2f1
T6651	1892-1896	PR:000006853	denotes	E2f2
T6652	1900-1904	PR:000006854	denotes	E2f3
T6653	1960-1964	PR:000006852	denotes	E2f1
T6655	2001-2008	GO:0051320	denotes	S-phase
T6656	2013-2020	GO:0007067	denotes	mitosis
T6657	2024-2026	PR:000013773	denotes	Rb
T6658	2090-2094	PR:000006852	denotes	E2f1
T6659	2122-2124	PR:000013773	denotes	Rb
T6660	2221-2224	UBERON:0001017	denotes	CNS
T6661	2228-2230	PR:000013773	denotes	Rb
T6662	2234-2241	UBERON:0000922	denotes	embryos
T6663	2338-2340	PR:000013773	denotes	Rb
T6664	2348-2354	UBERON:0000966	denotes	retina
T6665	2383-2392	GO:0006915	denotes	apoptosis
T6666	2411-2418	_FRAGMENT	denotes	bipolar
T6667	2432-2437	CL:0000103	denotes	cells
T6668	2423-2431	UBERON:0000045	denotes	ganglion
T6669	2423-2437	CL:0000740	denotes	ganglion cells
T6688	4381-4385	PR:000006852	denotes	E2f1
T6689	4403-4413	GO:0010467	denotes	expression
T6690	4452-4457	SO:0000704	denotes	genes
T6691	4463-4471	GO:0065007	denotes	regulate
T6692	4476-4486	GO:0007049	denotes	cell cycle
T6693	4491-4500	GO:0006915	denotes	apoptosis
T6694	4533-4543	GO:0007049	denotes	cell cycle
T6695	4594-4596	PR:000013773	denotes	Rb
T6696	4600-4606	UBERON:0000966	denotes	retina
T6697	4642-4646	PR:000006852	denotes	E2f1
T6698	4648-4652	PR:000006853	denotes	E2f2
T6699	4654-4659	PR:000028775	denotes	E2f3a
T6700	4665-4669	PR:000006858	denotes	E2f7
T6701	4693-4695	PR:000013773	denotes	Rb
T6702	4713-4717	PR:000006855	denotes	E2f4
T6703	4723-4727	PR:000006856	denotes	E2f5
T6704	4765-4769	CHEBI:472552	denotes	BrdU
T6705	4825-4829	PR:000006852	denotes	E2f1
T6706	4894-4898	PR:000006854	denotes	E2f3
R1513	T6667	T6666	_lexicallyChainedTo	cells,bipolar
R1514	T6675	T6674	_lexicallyChainedTo	cells,death of
R1515	T6677	T6676	_lexicallyChainedTo	neurons,bipolar
R10312	T34329	T34328	_lexicallyChainedTo	Cells,Ganglion
R10313	T34331	T34330	_lexicallyChainedTo	Cells,Rod

2_test

Id	Subject	Object	Predicate	Lexical cue
17608565-15193257-84868967	147-148	15193257	denotes	2
17608565-11719808-84868968	279-280	11719808	denotes	5
17608565-15193257-84868969	767-768	15193257	denotes	2
17608565-11719808-84868970	769-770	11719808	denotes	5
17608565-15193257-84868971	984-985	15193257	denotes	2
17608565-15231717-84868972	986-987	15231717	denotes	3
17608565-15193257-84868973	1339-1340	15193257	denotes	2
17608565-9774968-84868974	2324-2325	9774968	denotes	6
17608565-11146559-84868974	2324-2325	11146559	denotes	6
17608565-11230146-84868974	2324-2325	11230146	denotes	6
17608565-12065245-84868974	2324-2325	12065245	denotes	6
17608565-15193257-84868975	2475-2476	15193257	denotes	2
17608565-15231717-84868976	2477-2478	15231717	denotes	3
17608565-15193257-84868977	2697-2698	15193257	denotes	2
T96361	147-148	15193257	denotes	2
T68826	279-280	11719808	denotes	5
T63715	767-768	15193257	denotes	2
T65532	769-770	11719808	denotes	5
T7044	984-985	15193257	denotes	2
T88570	986-987	15231717	denotes	3
T61973	1339-1340	15193257	denotes	2
T60221	2324-2325	9774968	denotes	6
T11659	2324-2325	11146559	denotes	6
T49571	2324-2325	11230146	denotes	6
T50861	2324-2325	12065245	denotes	6
T2822	2475-2476	15193257	denotes	2
T607	2477-2478	15231717	denotes	3
T62078	2697-2698	15193257	denotes	2

PMC:1914394 / 11631-16565 JSONTXT

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2_test

PMC:1914394 / 11631-16565 JSON TXT