PMC:1892049 / 15944-16406
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1892049","sourcedb":"PMC","sourceid":"1892049","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1892049","text":"Western blot performed to examine ITPR1 levels in EBV immortalized lymphocytes from AUS1 affected family members carrying the ITPR1 deletion and from an AUS1 family member of unknown disease status who does not carry the deletion. Notably the samples from patients with ITPR1 deletion show a dramatic decrease in ITPR1 levels. To demonstrate equal loading, these samples were diluted one in five, and the Western blot was repeated using an antibody against ACTB.","tracks":[{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T16234","span":{"begin":34,"end":39},"obj":"PR_EXT:000009158"},{"id":"T16235","span":{"begin":50,"end":53},"obj":"NCBITaxon:10376"},{"id":"T16236","span":{"begin":67,"end":78},"obj":"CL:0000542"},{"id":"T16237","span":{"begin":126,"end":131},"obj":"PR_EXT:000009158"},{"id":"T16238","span":{"begin":132,"end":140},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T16239","span":{"begin":221,"end":229},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T16240","span":{"begin":270,"end":275},"obj":"PR_EXT:000009158"},{"id":"T16241","span":{"begin":276,"end":284},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T16242","span":{"begin":313,"end":318},"obj":"PR_EXT:000009158"},{"id":"T16243","span":{"begin":440,"end":448},"obj":"GO:0042571"},{"id":"T16244","span":{"begin":457,"end":461},"obj":"PR_EXT:000003676"}],"attributes":[{"subj":"T16234","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T16235","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T16236","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T16237","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T16238","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T16239","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T16240","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T16241","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T16242","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T16243","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T16244","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T16223","span":{"begin":34,"end":39},"obj":"PR:000009158"},{"id":"T16224","span":{"begin":50,"end":53},"obj":"NCBITaxon:10376"},{"id":"T16225","span":{"begin":67,"end":78},"obj":"CL:0000542"},{"id":"T16226","span":{"begin":126,"end":131},"obj":"PR:000009158"},{"id":"T16227","span":{"begin":270,"end":275},"obj":"PR:000009158"},{"id":"T16228","span":{"begin":313,"end":318},"obj":"PR:000009158"},{"id":"T16229","span":{"begin":440,"end":448},"obj":"GO:0042571"},{"id":"T16230","span":{"begin":457,"end":461},"obj":"PR:000003676"}],"attributes":[{"subj":"T16223","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T16224","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T16225","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T16226","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T16227","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T16228","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T16229","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T16230","pred":"source","obj":"craft-ca-core-dev"}]},{"project":"craft-sa-dev","denotations":[{"id":"T16337","span":{"begin":440,"end":448},"obj":"NN"},{"id":"T16338","span":{"begin":449,"end":456},"obj":"IN"},{"id":"T16261","span":{"begin":0,"end":7},"obj":"NNP"},{"id":"T16262","span":{"begin":8,"end":12},"obj":"NN"},{"id":"T16263","span":{"begin":13,"end":22},"obj":"VBN"},{"id":"T16264","span":{"begin":23,"end":25},"obj":"TO"},{"id":"T16265","span":{"begin":26,"end":33},"obj":"VB"},{"id":"T16266","span":{"begin":34,"end":39},"obj":"NN"},{"id":"T16267","span":{"begin":40,"end":46},"obj":"NNS"},{"id":"T16268","span":{"begin":47,"end":49},"obj":"IN"},{"id":"T16269","span":{"begin":50,"end":53},"obj":"NN"},{"id":"T16270","span":{"begin":67,"end":78},"obj":"NNS"},{"id":"T16271","span":{"begin":54,"end":66},"obj":"VBN"},{"id":"T16272","span":{"begin":79,"end":83},"obj":"IN"},{"id":"T16273","span":{"begin":84,"end":88},"obj":"NN"},{"id":"T16274","span":{"begin":89,"end":97},"obj":"VBN"},{"id":"T16275","span":{"begin":105,"end":112},"obj":"NNS"},{"id":"T16276","span":{"begin":98,"end":104},"obj":"NN"},{"id":"T16277","span":{"begin":113,"end":121},"obj":"VBG"},{"id":"T16278","span":{"begin":122,"end":125},"obj":"DT"},{"id":"T16279","span":{"begin":132,"end":140},"obj":"NN"},{"id":"T16280","span":{"begin":126,"end":131},"obj":"NN"},{"id":"T16281","span":{"begin":141,"end":144},"obj":"CC"},{"id":"T16282","span":{"begin":145,"end":149},"obj":"IN"},{"id":"T16283","span":{"begin":150,"end":152},"obj":"DT"},{"id":"T16284","span":{"begin":165,"end":171},"obj":"NN"},{"id":"T16285","span":{"begin":153,"end":157},"obj":"NN"},{"id":"T16286","span":{"begin":158,"end":164},"obj":"NN"},{"id":"T16287","span":{"begin":172,"end":174},"obj":"IN"},{"id":"T16288","span":{"begin":175,"end":182},"obj":"JJ"},{"id":"T16289","span":{"begin":191,"end":197},"obj":"NN"},{"id":"T16290","span":{"begin":183,"end":190},"obj":"NN"},{"id":"T16291","span":{"begin":198,"end":201},"obj":"WP"},{"id":"T16292","span":{"begin":211,"end":216},"obj":"VB"},{"id":"T16293","span":{"begin":202,"end":206},"obj":"VBZ"},{"id":"T16294","span":{"begin":207,"end":210},"obj":"RB"},{"id":"T16295","span":{"begin":217,"end":220},"obj":"DT"},{"id":"T16296","span":{"begin":221,"end":229},"obj":"NN"},{"id":"T16297","span":{"begin":229,"end":230},"obj":"."},{"id":"T16298","span":{"begin":230,"end":326},"obj":"sentence"},{"id":"T16299","span":{"begin":231,"end":238},"obj":"RB"},{"id":"T16300","span":{"begin":285,"end":289},"obj":"VBP"},{"id":"T16301","span":{"begin":239,"end":242},"obj":"DT"},{"id":"T16302","span":{"begin":243,"end":250},"obj":"NNS"},{"id":"T16303","span":{"begin":251,"end":255},"obj":"IN"},{"id":"T16304","span":{"begin":256,"end":264},"obj":"NNS"},{"id":"T16305","span":{"begin":265,"end":269},"obj":"IN"},{"id":"T16306","span":{"begin":270,"end":275},"obj":"NN"},{"id":"T16307","span":{"begin":276,"end":284},"obj":"NN"},{"id":"T16308","span":{"begin":290,"end":291},"obj":"DT"},{"id":"T16309","span":{"begin":301,"end":309},"obj":"NN"},{"id":"T16310","span":{"begin":292,"end":300},"obj":"JJ"},{"id":"T16311","span":{"begin":310,"end":312},"obj":"IN"},{"id":"T16312","span":{"begin":313,"end":318},"obj":"NN"},{"id":"T16313","span":{"begin":319,"end":325},"obj":"NNS"},{"id":"T16314","span":{"begin":325,"end":326},"obj":"."},{"id":"T16315","span":{"begin":326,"end":462},"obj":"sentence"},{"id":"T16316","span":{"begin":327,"end":329},"obj":"TO"},{"id":"T16317","span":{"begin":330,"end":341},"obj":"VB"},{"id":"T16318","span":{"begin":376,"end":383},"obj":"VBN"},{"id":"T16319","span":{"begin":342,"end":347},"obj":"JJ"},{"id":"T16320","span":{"begin":348,"end":355},"obj":"NN"},{"id":"T16321","span":{"begin":355,"end":357},"obj":","},{"id":"T16322","span":{"begin":357,"end":362},"obj":"DT"},{"id":"T16323","span":{"begin":363,"end":370},"obj":"NNS"},{"id":"T16324","span":{"begin":371,"end":375},"obj":"VBD"},{"id":"T16325","span":{"begin":384,"end":387},"obj":"CD"},{"id":"T16326","span":{"begin":388,"end":390},"obj":"IN"},{"id":"T16327","span":{"begin":391,"end":395},"obj":"CD"},{"id":"T16328","span":{"begin":395,"end":397},"obj":","},{"id":"T16329","span":{"begin":397,"end":400},"obj":"CC"},{"id":"T16330","span":{"begin":401,"end":404},"obj":"DT"},{"id":"T16331","span":{"begin":413,"end":417},"obj":"NN"},{"id":"T16332","span":{"begin":405,"end":412},"obj":"NNP"},{"id":"T16333","span":{"begin":422,"end":430},"obj":"VBN"},{"id":"T16334","span":{"begin":418,"end":421},"obj":"VBD"},{"id":"T16335","span":{"begin":431,"end":436},"obj":"VBG"},{"id":"T16336","span":{"begin":437,"end":439},"obj":"DT"},{"id":"T16339","span":{"begin":457,"end":461},"obj":"NN"},{"id":"T16340","span":{"begin":461,"end":462},"obj":"."}],"relations":[{"id":"R4862","pred":"compound","subj":"T16261","obj":"T16262"},{"id":"R4863","pred":"acl","subj":"T16263","obj":"T16262"},{"id":"R4864","pred":"aux","subj":"T16264","obj":"T16265"},{"id":"R4865","pred":"advcl","subj":"T16265","obj":"T16263"},{"id":"R4866","pred":"compound","subj":"T16266","obj":"T16267"},{"id":"R4867","pred":"dobj","subj":"T16267","obj":"T16265"},{"id":"R4868","pred":"prep","subj":"T16268","obj":"T16267"},{"id":"R4869","pred":"nmod","subj":"T16269","obj":"T16270"},{"id":"R4870","pred":"pobj","subj":"T16270","obj":"T16268"},{"id":"R4871","pred":"amod","subj":"T16271","obj":"T16270"},{"id":"R4872","pred":"prep","subj":"T16272","obj":"T16270"},{"id":"R4873","pred":"npadvmod","subj":"T16273","obj":"T16274"},{"id":"R4874","pred":"amod","subj":"T16274","obj":"T16275"},{"id":"R4875","pred":"pobj","subj":"T16275","obj":"T16272"},{"id":"R4876","pred":"compound","subj":"T16276","obj":"T16275"},{"id":"R4877","pred":"acl","subj":"T16277","obj":"T16275"},{"id":"R4878","pred":"det","subj":"T16278","obj":"T16279"},{"id":"R4879","pred":"dobj","subj":"T16279","obj":"T16277"},{"id":"R4880","pred":"compound","subj":"T16280","obj":"T16279"},{"id":"R4881","pred":"cc","subj":"T16281","obj":"T16272"},{"id":"R4882","pred":"conj","subj":"T16282","obj":"T16272"},{"id":"R4883","pred":"det","subj":"T16283","obj":"T16284"},{"id":"R4884","pred":"pobj","subj":"T16284","obj":"T16282"},{"id":"R4885","pred":"compound","subj":"T16285","obj":"T16284"},{"id":"R4886","pred":"compound","subj":"T16286","obj":"T16284"},{"id":"R4887","pred":"prep","subj":"T16287","obj":"T16284"},{"id":"R4888","pred":"amod","subj":"T16288","obj":"T16289"},{"id":"R4889","pred":"pobj","subj":"T16289","obj":"T16287"},{"id":"R4890","pred":"compound","subj":"T16290","obj":"T16289"},{"id":"R4891","pred":"dep","subj":"T16291","obj":"T16292"},{"id":"R4892","pred":"relcl","subj":"T16292","obj":"T16284"},{"id":"R4893","pred":"aux","subj":"T16293","obj":"T16292"},{"id":"R4894","pred":"neg","subj":"T16294","obj":"T16292"},{"id":"R4895","pred":"det","subj":"T16295","obj":"T16296"},{"id":"R4896","pred":"dobj","subj":"T16296","obj":"T16292"},{"id":"R4897","pred":"punct","subj":"T16297","obj":"T16262"},{"id":"R4898","pred":"advmod","subj":"T16299","obj":"T16300"},{"id":"R4899","pred":"det","subj":"T16301","obj":"T16302"},{"id":"R4900","pred":"nsubj","subj":"T16302","obj":"T16300"},{"id":"R4901","pred":"prep","subj":"T16303","obj":"T16302"},{"id":"R4902","pred":"pobj","subj":"T16304","obj":"T16303"},{"id":"R4903","pred":"prep","subj":"T16305","obj":"T16304"},{"id":"R4904","pred":"compound","subj":"T16306","obj":"T16307"},{"id":"R4905","pred":"pobj","subj":"T16307","obj":"T16305"},{"id":"R4906","pred":"det","subj":"T16308","obj":"T16309"},{"id":"R4907","pred":"dobj","subj":"T16309","obj":"T16300"},{"id":"R4908","pred":"amod","subj":"T16310","obj":"T16309"},{"id":"R4909","pred":"prep","subj":"T16311","obj":"T16309"},{"id":"R4910","pred":"compound","subj":"T16312","obj":"T16313"},{"id":"R4911","pred":"pobj","subj":"T16313","obj":"T16311"},{"id":"R4912","pred":"punct","subj":"T16314","obj":"T16300"},{"id":"R4913","pred":"aux","subj":"T16316","obj":"T16317"},{"id":"R4914","pred":"advcl","subj":"T16317","obj":"T16318"},{"id":"R4915","pred":"amod","subj":"T16319","obj":"T16320"},{"id":"R4916","pred":"dobj","subj":"T16320","obj":"T16317"},{"id":"R4917","pred":"punct","subj":"T16321","obj":"T16318"},{"id":"R4918","pred":"det","subj":"T16322","obj":"T16323"},{"id":"R4919","pred":"nsubjpass","subj":"T16323","obj":"T16318"},{"id":"R4920","pred":"auxpass","subj":"T16324","obj":"T16318"},{"id":"R4921","pred":"npadvmod","subj":"T16325","obj":"T16318"},{"id":"R4922","pred":"prep","subj":"T16326","obj":"T16325"},{"id":"R4923","pred":"pobj","subj":"T16327","obj":"T16326"},{"id":"R4924","pred":"punct","subj":"T16328","obj":"T16318"},{"id":"R4925","pred":"cc","subj":"T16329","obj":"T16318"},{"id":"R4926","pred":"det","subj":"T16330","obj":"T16331"},{"id":"R4927","pred":"nsubjpass","subj":"T16331","obj":"T16333"},{"id":"R4928","pred":"compound","subj":"T16332","obj":"T16331"},{"id":"R4929","pred":"conj","subj":"T16333","obj":"T16318"},{"id":"R4930","pred":"auxpass","subj":"T16334","obj":"T16333"},{"id":"R4931","pred":"advcl","subj":"T16335","obj":"T16333"},{"id":"R4932","pred":"det","subj":"T16336","obj":"T16337"},{"id":"R4933","pred":"dobj","subj":"T16337","obj":"T16335"},{"id":"R4934","pred":"prep","subj":"T16338","obj":"T16337"},{"id":"R4935","pred":"pobj","subj":"T16339","obj":"T16338"},{"id":"R4936","pred":"punct","subj":"T16340","obj":"T16318"}],"attributes":[{"subj":"T16337","pred":"source","obj":"craft-sa-dev"},{"subj":"T16338","pred":"source","obj":"craft-sa-dev"},{"subj":"T16261","pred":"source","obj":"craft-sa-dev"},{"subj":"T16262","pred":"source","obj":"craft-sa-dev"},{"subj":"T16263","pred":"source","obj":"craft-sa-dev"},{"subj":"T16264","pred":"source","obj":"craft-sa-dev"},{"subj":"T16265","pred":"source","obj":"craft-sa-dev"},{"subj":"T16266","pred":"source","obj":"craft-sa-dev"},{"subj":"T16267","pred":"source","obj":"craft-sa-dev"},{"subj":"T16268","pred":"source","obj":"craft-sa-dev"},{"subj":"T16269","pred":"source","obj":"craft-sa-dev"},{"subj":"T16270","pred":"source","obj":"craft-sa-dev"},{"subj":"T16271","pred":"source","obj":"craft-sa-dev"},{"subj":"T16272","pred":"source","obj":"craft-sa-dev"},{"subj":"T16273","pred":"source","obj":"craft-sa-dev"},{"subj":"T16274","pred":"source","obj":"craft-sa-dev"},{"subj":"T16275","pred":"source","obj":"craft-sa-dev"},{"subj":"T16276","pred":"source","obj":"craft-sa-dev"},{"subj":"T16277","pred":"source","obj":"craft-sa-dev"},{"subj":"T16278","pred":"source","obj":"craft-sa-dev"},{"subj":"T16279","pred":"source","obj":"craft-sa-dev"},{"subj":"T16280","pred":"source","obj":"craft-sa-dev"},{"subj":"T16281","pred":"source","obj":"craft-sa-dev"},{"subj":"T16282","pred":"source","obj":"craft-sa-dev"},{"subj":"T16283","pred":"source","obj":"craft-sa-dev"},{"subj":"T16284","pred":"source","obj":"craft-sa-dev"},{"subj":"T16285","pred":"source","obj":"craft-sa-dev"},{"subj":"T16286","pred":"source","obj":"craft-sa-dev"},{"subj":"T16287","pred":"source","obj":"craft-sa-dev"},{"subj":"T16288","pred":"source","obj":"craft-sa-dev"},{"subj":"T16289","pred":"source","obj":"craft-sa-dev"},{"subj":"T16290","pred":"source","obj":"craft-sa-dev"},{"subj":"T16291","pred":"source","obj":"craft-sa-dev"},{"subj":"T16292","pred":"source","obj":"craft-sa-dev"},{"subj":"T16293","pred":"source","obj":"craft-sa-dev"},{"subj":"T16294","pred":"source","obj":"craft-sa-dev"},{"subj":"T16295","pred":"source","obj":"craft-sa-dev"},{"subj":"T16296","pred":"source","obj":"craft-sa-dev"},{"subj":"T16297","pred":"source","obj":"craft-sa-dev"},{"subj":"T16298","pred":"source","obj":"craft-sa-dev"},{"subj":"T16299","pred":"source","obj":"craft-sa-dev"},{"subj":"T16300","pred":"source","obj":"craft-sa-dev"},{"subj":"T16301","pred":"source","obj":"craft-sa-dev"},{"subj":"T16302","pred":"source","obj":"craft-sa-dev"},{"subj":"T16303","pred":"source","obj":"craft-sa-dev"},{"subj":"T16304","pred":"source","obj":"craft-sa-dev"},{"subj":"T16305","pred":"source","obj":"craft-sa-dev"},{"subj":"T16306","pred":"source","obj":"craft-sa-dev"},{"subj":"T16307","pred":"source","obj":"craft-sa-dev"},{"subj":"T16308","pred":"source","obj":"craft-sa-dev"},{"subj":"T16309","pred":"source","obj":"craft-sa-dev"},{"subj":"T16310","pred":"source","obj":"craft-sa-dev"},{"subj":"T16311","pred":"source","obj":"craft-sa-dev"},{"subj":"T16312","pred":"source","obj":"craft-sa-dev"},{"subj":"T16313","pred":"source","obj":"craft-sa-dev"},{"subj":"T16314","pred":"source","obj":"craft-sa-dev"},{"subj":"T16315","pred":"source","obj":"craft-sa-dev"},{"subj":"T16316","pred":"source","obj":"craft-sa-dev"},{"subj":"T16317","pred":"source","obj":"craft-sa-dev"},{"subj":"T16318","pred":"source","obj":"craft-sa-dev"},{"subj":"T16319","pred":"source","obj":"craft-sa-dev"},{"subj":"T16320","pred":"source","obj":"craft-sa-dev"},{"subj":"T16321","pred":"source","obj":"craft-sa-dev"},{"subj":"T16322","pred":"source","obj":"craft-sa-dev"},{"subj":"T16323","pred":"source","obj":"craft-sa-dev"},{"subj":"T16324","pred":"source","obj":"craft-sa-dev"},{"subj":"T16325","pred":"source","obj":"craft-sa-dev"},{"subj":"T16326","pred":"source","obj":"craft-sa-dev"},{"subj":"T16327","pred":"source","obj":"craft-sa-dev"},{"subj":"T16328","pred":"source","obj":"craft-sa-dev"},{"subj":"T16329","pred":"source","obj":"craft-sa-dev"},{"subj":"T16330","pred":"source","obj":"craft-sa-dev"},{"subj":"T16331","pred":"source","obj":"craft-sa-dev"},{"subj":"T16332","pred":"source","obj":"craft-sa-dev"},{"subj":"T16333","pred":"source","obj":"craft-sa-dev"},{"subj":"T16334","pred":"source","obj":"craft-sa-dev"},{"subj":"T16335","pred":"source","obj":"craft-sa-dev"},{"subj":"T16336","pred":"source","obj":"craft-sa-dev"},{"subj":"T16339","pred":"source","obj":"craft-sa-dev"},{"subj":"T16340","pred":"source","obj":"craft-sa-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-ca-core-ex-dev","color":"#93e5ec","default":true},{"id":"craft-ca-core-dev","color":"#ecd993"},{"id":"craft-sa-dev","color":"#bf93ec"}]}]}}