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With this strategy, we identified 21 candidate genes for 8 small-effect QTL regulating CIA susceptibility. Our future studies will be carried out using two approaches. The first is generating congenic animals for promising small-effect QTL that have relatively high P values and overlap with previously-identified arthritis QTL. The second approach is investigating candidate genes using both mouse and human studies. Candidate genes will be selected according to their function and polymorphism between the two strains. Thereafter, we will generate knock-out mice to investigate the role of the genes in CIA. For the loci whose counterparts on the human genome are linked to RA, we will investigate the candidate genes using case-control association studies in RA cohorts."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T14915","span":{"begin":509,"end":514},"obj":"SO_EXT:0000704"},{"id":"T14904","span":{"begin":53,"end":58},"obj":"SO_EXT:0000704"},{"id":"T14905","span":{"begin":76,"end":79},"obj":"SO_EXT:0000771"},{"id":"T14906","span":{"begin":128,"end":133},"obj":"SO_EXT:0000704"},{"id":"T14907","span":{"begin":153,"end":156},"obj":"SO_EXT:0000771"},{"id":"T14908","span":{"begin":157,"end":167},"obj":"GO:0065007"},{"id":"T14909","span":{"begin":282,"end":289},"obj":"NCBITaxon:33208"},{"id":"T14910","span":{"begin":317,"end":320},"obj":"SO_EXT:0000771"},{"id":"T14911","span":{"begin":405,"end":408},"obj":"SO_EXT:0000771"},{"id":"T14912","span":{"begin":457,"end":462},"obj":"SO_EXT:0000704"},{"id":"T14913","span":{"begin":474,"end":479},"obj":"NCBITaxon:10088"},{"id":"T14914","span":{"begin":484,"end":489},"obj":"NCBITaxon:9606"},{"id":"T14916","span":{"begin":564,"end":576},"obj":"SO_EXT:polymorphism"},{"id":"T14917","span":{"begin":641,"end":645},"obj":"NCBITaxon:10088"},{"id":"T14918","span":{"begin":677,"end":682},"obj":"SO_EXT:0000704"},{"id":"T14919","span":{"begin":730,"end":735},"obj":"NCBITaxon:9606"},{"id":"T14920","span":{"begin":736,"end":742},"obj":"SO_EXT:0001026"},{"id":"T14921","span":{"begin":795,"end":800},"obj":"SO_EXT:0000704"}],"text":"Conclusion\nWe present a strategy to search candidate genes for small-effect QTL. With this strategy, we identified 21 candidate genes for 8 small-effect QTL regulating CIA susceptibility. Our future studies will be carried out using two approaches. The first is generating congenic animals for promising small-effect QTL that have relatively high P values and overlap with previously-identified arthritis QTL. The second approach is investigating candidate genes using both mouse and human studies. Candidate genes will be selected according to their function and polymorphism between the two strains. Thereafter, we will generate knock-out mice to investigate the role of the genes in CIA. For the loci whose counterparts on the human genome are linked to RA, we will investigate the candidate genes using case-control association studies in RA cohorts."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T14887","span":{"begin":53,"end":58},"obj":"SO:0000704"},{"id":"T14888","span":{"begin":76,"end":79},"obj":"SO:0000771"},{"id":"T14889","span":{"begin":128,"end":133},"obj":"SO:0000704"},{"id":"T14890","span":{"begin":153,"end":156},"obj":"SO:0000771"},{"id":"T14891","span":{"begin":157,"end":167},"obj":"GO:0065007"},{"id":"T14892","span":{"begin":282,"end":289},"obj":"NCBITaxon:33208"},{"id":"T14893","span":{"begin":317,"end":320},"obj":"SO:0000771"},{"id":"T14894","span":{"begin":405,"end":408},"obj":"SO:0000771"},{"id":"T14895","span":{"begin":457,"end":462},"obj":"SO:0000704"},{"id":"T14896","span":{"begin":474,"end":479},"obj":"NCBITaxon:10088"},{"id":"T14897","span":{"begin":484,"end":489},"obj":"NCBITaxon:9606"},{"id":"T14898","span":{"begin":509,"end":514},"obj":"SO:0000704"},{"id":"T14899","span":{"begin":641,"end":645},"obj":"NCBITaxon:10088"},{"id":"T14900","span":{"begin":677,"end":682},"obj":"SO:0000704"},{"id":"T14901","span":{"begin":730,"end":735},"obj":"NCBITaxon:9606"},{"id":"T14902","span":{"begin":736,"end":742},"obj":"SO:0001026"},{"id":"T14903","span":{"begin":795,"end":800},"obj":"SO:0000704"}],"text":"Conclusion\nWe present a strategy to search candidate genes for small-effect QTL. With this strategy, we identified 21 candidate genes for 8 small-effect QTL regulating CIA susceptibility. Our future studies will be carried out using two approaches. The first is generating congenic animals for promising small-effect QTL that have relatively high P values and overlap with previously-identified arthritis QTL. The second approach is investigating candidate genes using both mouse and human studies. Candidate genes will be selected according to their function and polymorphism between the two strains. Thereafter, we will generate knock-out mice to investigate the role of the genes in CIA. For the loci whose counterparts on the human genome are linked to RA, we will investigate the candidate genes using case-control association studies in RA cohorts."}