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signaling is of critical importance in several stages of kidney development. Mutual inductive interactions between the ureteric bud and metanephric mesenchyme drive nephrogenesis [1]. The ureteric bud synthesizes Wnt9b, which is essential for induction of the mesenchyme to form nephrons [2]. Wnt4 is made by the induced metanephric mesenchyme and is also required for nephrogenesis [3]. Furthermore, Wnt11, secreted by the ureteric bud tips, participates in a positive feedback loop promoting glial cell line-derived neurotrophic factor (GDNF) expression by the metanephric mesenchyme [4]. Mutations in Wnt9b or Wnt4 result in a dramatic block in nephron formation, while Wnt11 mutants show a significant reduction in nephron number. It is interesting to note that Wnt4 and Wnt11 have been shown to signal, at least in some cases, through noncanonical pathways [5-7], while there is evidence indicating that Wnt9b activates canonical Wnt signaling in the kidney [2]."}

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