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The developmental stages of meiotic prophase based on SYCP3 organization are indicated in each panel. By pachynema, all autosomes are fully synapsed, and the XY bivalent is synapsed only at the pseudoautosomal region in both wild-type and mutant cells.\n(B) Testicular cells in zygonema and pachynema spread and stained with antibodies to RAD51 (green) and SYCP3 (red). Size and distribution of RAD51 foci are similar between wild-type and mutant spermatocytes."}

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{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T29585","span":{"begin":7,"end":15},"obj":"GO:0007129"},{"id":"T29586","span":{"begin":20,"end":33},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T29587","span":{"begin":37,"end":42},"obj":"PR_EXT:000006549"},{"id":"T29588","span":{"begin":43,"end":49},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T29589","span":{"begin":50,"end":60},"obj":"CL:0000586"},{"id":"T29590","span":{"begin":55,"end":60},"obj":"CL_GO_EXT:cell"},{"id":"T29591","span":{"begin":65,"end":75},"obj":"UBERON:0000473"},{"id":"T29592","span":{"begin":76,"end":81},"obj":"CL_GO_EXT:cell"},{"id":"T29593","span":{"begin":87,"end":92},"obj":"PR_EXT:000006549"},{"id":"T29594","span":{"begin":107,"end":108},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T29595","span":{"begin":109,"end":110},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T29596","span":{"begin":127,"end":128},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T29597","span":{"begin":129,"end":130},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T29598","span":{"begin":132,"end":138},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T29599","span":{"begin":139,"end":143},"obj":"NCBITaxon:10088"},{"id":"T29600","span":{"begin":173,"end":181},"obj":"GO:0042571"},{"id":"T29601","span":{"begin":185,"end":190},"obj":"PR_EXT:000015865"},{"id":"T29602","span":{"begin":226,"end":233},"obj":"GO:0007126"},{"id":"T29603","span":{"begin":234,"end":242},"obj":"GO:0051324"},{"id":"T29604","span":{"begin":252,"end":257},"obj":"PR_EXT:000015865"},{"id":"T29605","span":{"begin":303,"end":312},"obj":"GO:0000239"},{"id":"T29606","span":{"begin":318,"end":327},"obj":"GO:0030849"},{"id":"T29607","span":{"begin":338,"end":346},"obj":"GO:0007129"},{"id":"T29608","span":{"begin":371,"end":379},"obj":"GO:0007129"},{"id":"T29609","span":{"begin":423,"end":432},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T29610","span":{"begin":437,"end":443},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T29611","span":{"begin":444,"end":449},"obj":"CL_GO_EXT:cell"},{"id":"T29612","span":{"begin":455,"end":465},"obj":"UBERON:0000473"},{"id":"T29613","span":{"begin":466,"end":471},"obj":"CL_GO_EXT:cell"},{"id":"T29614","span":{"begin":475,"end":483},"obj":"GO:0000238"},{"id":"T29615","span":{"begin":488,"end":497},"obj":"GO:0000239"},{"id":"T29616","span":{"begin":522,"end":532},"obj":"GO:0042571"},{"id":"T29617","span":{"begin":536,"end":541},"obj":"PR_EXT:000013672"},{"id":"T29618","span":{"begin":554,"end":559},"obj":"PR_EXT:000015865"},{"id":"T29619","span":{"begin":592,"end":597},"obj":"PR_EXT:000013672"},{"id":"T29620","span":{"begin":623,"end":632},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T29621","span":{"begin":637,"end":643},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T29622","span":{"begin":644,"end":657},"obj":"CL:0000017"}],"text":"Normal Synapsis and Recombination in Dmrt7 Mutant Germ Cells\n(A) Testicular cells from Dmrt7 heterozygous (+/−) or homozygous (−/−) mutant mice were spread and stained with antibody to SYCP3 (red). The developmental stages of meiotic prophase based on SYCP3 organization are indicated in each panel. By pachynema, all autosomes are fully synapsed, and the XY bivalent is synapsed only at the pseudoautosomal region in both wild-type and mutant cells.\n(B) Testicular cells in zygonema and pachynema spread and stained with antibodies to RAD51 (green) and SYCP3 (red). Size and distribution of RAD51 foci are similar between wild-type and mutant spermatocytes."}