PMC:1852721 / 76290-77078 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1852721","sourcedb":"PMC","sourceid":"1852721","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1852721","text":"Mendelian (monogenic or monolocus) phenotypes and their molecular basis will continue to be the principal fodder for the ever enlarging catalogs.82 The mechanism by which the mutation leads to the phenotype (the steps from gene to phene) will always be important information for cataloging. There will be attention also to collation of information on genetic, epigenetic, and environmental modifiers of Mendelian phenotypes. A challenge OMIM already faces is how to catalog complex phenotypes and complex genotypes and their functional relationships to each other and to include epigenetics (and epigenomics), the interaction of genes and gene products, the interaction with and influence of environment, and the emergent phenotypes resulting from these interactions—no small undertaking.","tracks":[{"project":"2_test","denotations":[{"id":"17357067-16534515-2054096","span":{"begin":145,"end":147},"obj":"16534515"}],"attributes":[{"subj":"17357067-16534515-2054096","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#eca993","default":true}]}]}}