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7 Aberrant apoptosis of NCCs in Alk5/Wnt1-Cre mutants. TUNEL (A-H) and Cleaved Caspase-3 (I, J) staining at E11.0 demonstrates a notable increase in apoptosis in Alk5/Wnt1-Cre mutants (B, H, J) on the aortic sac level when compared to controls (A, G, I) or Alk2/Wnt1-Cre mutants (C) (frontal sections), while sections on the OFT level do not demonstrate differences between controls (D) and Alk5 (E) or Alk2 (F) mutants. G,H, TUNEL staining of lacZ-stained embryos demonstrates that apoptotic cells are of neural crest origin. G, control; H, mutant. AS, aortic sac, arrows point to clusters of apoptotic cells surrounding the aortic sac."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T20145","span":{"begin":19,"end":28},"obj":"GO:0006915"},{"id":"T20146","span":{"begin":32,"end":36},"obj":"CL_EXT:neural_crest_cell"},{"id":"T20147","span":{"begin":40,"end":44},"obj":"PR_EXT:000000047"},{"id":"T20148","span":{"begin":45,"end":49},"obj":"PR_EXT:000017435"},{"id":"T20149","span":{"begin":54,"end":61},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T20150","span":{"begin":79,"end":86},"obj":"MOP:0000780"},{"id":"T20151","span":{"begin":79,"end":96},"obj":"PR_EXT:000018762"},{"id":"T20152","span":{"begin":157,"end":166},"obj":"GO:0006915"},{"id":"T20153","span":{"begin":170,"end":174},"obj":"PR_EXT:000000047"},{"id":"T20154","span":{"begin":175,"end":179},"obj":"PR_EXT:000017435"},{"id":"T20155","span":{"begin":184,"end":191},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T20156","span":{"begin":209,"end":219},"obj":"UBERON:0005432"},{"id":"T20157","span":{"begin":265,"end":269},"obj":"PR_EXT:000000067"},{"id":"T20158","span":{"begin":270,"end":274},"obj":"PR_EXT:000017435"},{"id":"T20159","span":{"begin":279,"end":286},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T20160","span":{"begin":333,"end":336},"obj":"UBERON:0004145"},{"id":"T20161","span":{"begin":399,"end":403},"obj":"PR_EXT:000000047"},{"id":"T20162","span":{"begin":411,"end":415},"obj":"PR_EXT:000000067"},{"id":"T20163","span":{"begin":420,"end":427},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T20164","span":{"begin":452,"end":456},"obj":"PR_EXT:000033987"},{"id":"T20165","span":{"begin":465,"end":472},"obj":"UBERON:0000922"},{"id":"T20166","span":{"begin":491,"end":500},"obj":"GO_PATO_EXT:apoptotic_process_or_quality"},{"id":"T20167","span":{"begin":491,"end":506},"obj":"CL:0000445"},{"id":"T20168","span":{"begin":501,"end":506},"obj":"CL_GO_EXT:cell"},{"id":"T20169","span":{"begin":514,"end":526},"obj":"UBERON:0002342"},{"id":"T20170","span":{"begin":550,"end":556},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T20171","span":{"begin":558,"end":560},"obj":"UBERON:0005432"},{"id":"T20172","span":{"begin":562,"end":572},"obj":"UBERON:0005432"},{"id":"T20173","span":{"begin":590,"end":601},"obj":"_FRAGMENT"},{"id":"T20174","span":{"begin":612,"end":617},"obj":"UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population"},{"id":"T20175","span":{"begin":602,"end":611},"obj":"GO_PATO_EXT:apoptotic_process_or_quality"},{"id":"T20176","span":{"begin":602,"end":617},"obj":"CL:0000445"},{"id":"T20177","span":{"begin":612,"end":617},"obj":"CL_GO_EXT:cell"},{"id":"T20178","span":{"begin":634,"end":644},"obj":"UBERON:0005432"}],"relations":[{"id":"R6121","pred":"_lexicallyChainedTo","subj":"T20174","obj":"T20173"}],"text":"Figure 7 Aberrant apoptosis of NCCs in Alk5/Wnt1-Cre mutants. TUNEL (A-H) and Cleaved Caspase-3 (I, J) staining at E11.0 demonstrates a notable increase in apoptosis in Alk5/Wnt1-Cre mutants (B, H, J) on the aortic sac level when compared to controls (A, G, I) or Alk2/Wnt1-Cre mutants (C) (frontal sections), while sections on the OFT level do not demonstrate differences between controls (D) and Alk5 (E) or Alk2 (F) mutants. G,H, TUNEL staining of lacZ-stained embryos demonstrates that apoptotic cells are of neural crest origin. G, control; H, mutant. AS, aortic sac, arrows point to clusters of apoptotic cells surrounding the aortic sac."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T20123","span":{"begin":19,"end":28},"obj":"GO:0006915"},{"id":"T20124","span":{"begin":40,"end":44},"obj":"PR:000000047"},{"id":"T20125","span":{"begin":45,"end":49},"obj":"PR:000017435"},{"id":"T20126","span":{"begin":79,"end":86},"obj":"MOP:0000780"},{"id":"T20127","span":{"begin":79,"end":96},"obj":"PR:000018762"},{"id":"T20128","span":{"begin":157,"end":166},"obj":"GO:0006915"},{"id":"T20129","span":{"begin":170,"end":174},"obj":"PR:000000047"},{"id":"T20130","span":{"begin":175,"end":179},"obj":"PR:000017435"},{"id":"T20131","span":{"begin":209,"end":219},"obj":"UBERON:0005432"},{"id":"T20132","span":{"begin":265,"end":269},"obj":"PR:000000067"},{"id":"T20133","span":{"begin":270,"end":274},"obj":"PR:000017435"},{"id":"T20134","span":{"begin":333,"end":336},"obj":"UBERON:0004145"},{"id":"T20135","span":{"begin":399,"end":403},"obj":"PR:000000047"},{"id":"T20136","span":{"begin":411,"end":415},"obj":"PR:000000067"},{"id":"T20137","span":{"begin":452,"end":456},"obj":"PR:000033987"},{"id":"T20138","span":{"begin":465,"end":472},"obj":"UBERON:0000922"},{"id":"T20139","span":{"begin":491,"end":506},"obj":"CL:0000445"},{"id":"T20140","span":{"begin":514,"end":526},"obj":"UBERON:0002342"},{"id":"T20141","span":{"begin":558,"end":560},"obj":"UBERON:0005432"},{"id":"T20142","span":{"begin":562,"end":572},"obj":"UBERON:0005432"},{"id":"T20143","span":{"begin":602,"end":617},"obj":"CL:0000445"},{"id":"T20144","span":{"begin":634,"end":644},"obj":"UBERON:0005432"}],"text":"Figure 7 Aberrant apoptosis of NCCs in Alk5/Wnt1-Cre mutants. TUNEL (A-H) and Cleaved Caspase-3 (I, J) staining at E11.0 demonstrates a notable increase in apoptosis in Alk5/Wnt1-Cre mutants (B, H, J) on the aortic sac level when compared to controls (A, G, I) or Alk2/Wnt1-Cre mutants (C) (frontal sections), while sections on the OFT level do not demonstrate differences between controls (D) and Alk5 (E) or Alk2 (F) mutants. G,H, TUNEL staining of lacZ-stained embryos demonstrates that apoptotic cells are of neural crest origin. G, control; H, mutant. AS, aortic sac, arrows point to clusters of apoptotic cells surrounding the aortic sac."}