PMC:1584416 / 29888-30120 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1584416","sourcedb":"PMC","sourceid":"1584416","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1584416","text":" Our data suggest that certain presumed null alleles, although unable on their own to support basal transcription, may in fact have a substantial impact on disease outcome in compound heterozygous humans, as they do in mouse models.","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T5663","span":{"begin":0,"end":232},"obj":"sentence"},{"id":"T5664","span":{"begin":1,"end":4},"obj":"PRP$"},{"id":"T5665","span":{"begin":5,"end":9},"obj":"NNS"},{"id":"T5666","span":{"begin":10,"end":17},"obj":"VBP"},{"id":"T5667","span":{"begin":18,"end":22},"obj":"IN"},{"id":"T5668","span":{"begin":127,"end":131},"obj":"VB"},{"id":"T5669","span":{"begin":23,"end":30},"obj":"JJ"},{"id":"T5670","span":{"begin":45,"end":52},"obj":"NNS"},{"id":"T5671","span":{"begin":31,"end":39},"obj":"VBN"},{"id":"T5672","span":{"begin":40,"end":44},"obj":"JJ"},{"id":"T5673","span":{"begin":52,"end":54},"obj":","},{"id":"T5674","span":{"begin":54,"end":62},"obj":"IN"},{"id":"T5675","span":{"begin":63,"end":69},"obj":"JJ"},{"id":"T5676","span":{"begin":70,"end":72},"obj":"IN"},{"id":"T5677","span":{"begin":86,"end":93},"obj":"VB"},{"id":"T5678","span":{"begin":73,"end":78},"obj":"PRP$"},{"id":"T5679","span":{"begin":79,"end":82},"obj":"NN"},{"id":"T5680","span":{"begin":83,"end":85},"obj":"TO"},{"id":"T5681","span":{"begin":94,"end":99},"obj":"JJ"},{"id":"T5682","span":{"begin":100,"end":113},"obj":"NN"},{"id":"T5683","span":{"begin":113,"end":115},"obj":","},{"id":"T5684","span":{"begin":115,"end":118},"obj":"MD"},{"id":"T5685","span":{"begin":119,"end":121},"obj":"IN"},{"id":"T5686","span":{"begin":122,"end":126},"obj":"NN"},{"id":"T5687","span":{"begin":132,"end":133},"obj":"DT"},{"id":"T5688","span":{"begin":146,"end":152},"obj":"NN"},{"id":"T5689","span":{"begin":134,"end":145},"obj":"JJ"},{"id":"T5690","span":{"begin":153,"end":155},"obj":"IN"},{"id":"T5691","span":{"begin":156,"end":163},"obj":"NN"},{"id":"T5692","span":{"begin":164,"end":171},"obj":"NN"},{"id":"T5693","span":{"begin":172,"end":174},"obj":"IN"},{"id":"T5694","span":{"begin":175,"end":183},"obj":"NN"},{"id":"T5695","span":{"begin":197,"end":203},"obj":"NNS"},{"id":"T5696","span":{"begin":184,"end":196},"obj":"JJ"},{"id":"T5697","span":{"begin":203,"end":205},"obj":","},{"id":"T5698","span":{"begin":205,"end":207},"obj":"IN"},{"id":"T5699","span":{"begin":216,"end":218},"obj":"IN"},{"id":"T5700","span":{"begin":208,"end":212},"obj":"PRP"},{"id":"T5701","span":{"begin":213,"end":215},"obj":"VBP"},{"id":"T5702","span":{"begin":219,"end":224},"obj":"NN"},{"id":"T5703","span":{"begin":225,"end":231},"obj":"NNS"},{"id":"T5704","span":{"begin":231,"end":232},"obj":"."}],"relations":[{"id":"R3808","pred":"poss","subj":"T5664","obj":"T5665"},{"id":"R3809","pred":"nsubj","subj":"T5665","obj":"T5666"},{"id":"R3810","pred":"mark","subj":"T5667","obj":"T5668"},{"id":"R3811","pred":"ccomp","subj":"T5668","obj":"T5666"},{"id":"R3812","pred":"amod","subj":"T5669","obj":"T5670"},{"id":"R3813","pred":"nsubj","subj":"T5670","obj":"T5668"},{"id":"R3814","pred":"advmod","subj":"T5671","obj":"T5672"},{"id":"R3815","pred":"amod","subj":"T5672","obj":"T5670"},{"id":"R3816","pred":"punct","subj":"T5673","obj":"T5668"},{"id":"R3817","pred":"mark","subj":"T5674","obj":"T5675"},{"id":"R3818","pred":"advcl","subj":"T5675","obj":"T5668"},{"id":"R3819","pred":"prep","subj":"T5676","obj":"T5677"},{"id":"R3820","pred":"xcomp","subj":"T5677","obj":"T5675"},{"id":"R3821","pred":"poss","subj":"T5678","obj":"T5679"},{"id":"R3822","pred":"pobj","subj":"T5679","obj":"T5676"},{"id":"R3823","pred":"aux","subj":"T5680","obj":"T5677"},{"id":"R3824","pred":"amod","subj":"T5681","obj":"T5682"},{"id":"R3825","pred":"dobj","subj":"T5682","obj":"T5677"},{"id":"R3826","pred":"punct","subj":"T5683","obj":"T5668"},{"id":"R3827","pred":"aux","subj":"T5684","obj":"T5668"},{"id":"R3828","pred":"prep","subj":"T5685","obj":"T5668"},{"id":"R3829","pred":"pobj","subj":"T5686","obj":"T5685"},{"id":"R3830","pred":"det","subj":"T5687","obj":"T5688"},{"id":"R3831","pred":"dobj","subj":"T5688","obj":"T5668"},{"id":"R3832","pred":"amod","subj":"T5689","obj":"T5688"},{"id":"R3833","pred":"prep","subj":"T5690","obj":"T5688"},{"id":"R3834","pred":"compound","subj":"T5691","obj":"T5692"},{"id":"R3835","pred":"pobj","subj":"T5692","obj":"T5690"},{"id":"R3836","pred":"prep","subj":"T5693","obj":"T5688"},{"id":"R3837","pred":"nmod","subj":"T5694","obj":"T5695"},{"id":"R3838","pred":"pobj","subj":"T5695","obj":"T5693"},{"id":"R3839","pred":"amod","subj":"T5696","obj":"T5695"},{"id":"R3840","pred":"punct","subj":"T5697","obj":"T5668"},{"id":"R3841","pred":"mark","subj":"T5698","obj":"T5699"},{"id":"R3842","pred":"advcl","subj":"T5699","obj":"T5668"},{"id":"R3843","pred":"nsubj","subj":"T5700","obj":"T5699"},{"id":"R3844","pred":"aux","subj":"T5701","obj":"T5699"},{"id":"R3845","pred":"compound","subj":"T5702","obj":"T5703"},{"id":"R3846","pred":"pobj","subj":"T5703","obj":"T5699"},{"id":"R3847","pred":"punct","subj":"T5704","obj":"T5666"}],"attributes":[{"subj":"T5663","pred":"source","obj":"craft-sa-dev"},{"subj":"T5664","pred":"source","obj":"craft-sa-dev"},{"subj":"T5665","pred":"source","obj":"craft-sa-dev"},{"subj":"T5666","pred":"source","obj":"craft-sa-dev"},{"subj":"T5667","pred":"source","obj":"craft-sa-dev"},{"subj":"T5668","pred":"source","obj":"craft-sa-dev"},{"subj":"T5669","pred":"source","obj":"craft-sa-dev"},{"subj":"T5670","pred":"source","obj":"craft-sa-dev"},{"subj":"T5671","pred":"source","obj":"craft-sa-dev"},{"subj":"T5672","pred":"source","obj":"craft-sa-dev"},{"subj":"T5673","pred":"source","obj":"craft-sa-dev"},{"subj":"T5674","pred":"source","obj":"craft-sa-dev"},{"subj":"T5675","pred":"source","obj":"craft-sa-dev"},{"subj":"T5676","pred":"source","obj":"craft-sa-dev"},{"subj":"T5677","pred":"source","obj":"craft-sa-dev"},{"subj":"T5678","pred":"source","obj":"craft-sa-dev"},{"subj":"T5679","pred":"source","obj":"craft-sa-dev"},{"subj":"T5680","pred":"source","obj":"craft-sa-dev"},{"subj":"T5681","pred":"source","obj":"craft-sa-dev"},{"subj":"T5682","pred":"source","obj":"craft-sa-dev"},{"subj":"T5683","pred":"source","obj":"craft-sa-dev"},{"subj":"T5684","pred":"source","obj":"craft-sa-dev"},{"subj":"T5685","pred":"source","obj":"craft-sa-dev"},{"subj":"T5686","pred":"source","obj":"craft-sa-dev"},{"subj":"T5687","pred":"source","obj":"craft-sa-dev"},{"subj":"T5688","pred":"source","obj":"craft-sa-dev"},{"subj":"T5689","pred":"source","obj":"craft-sa-dev"},{"subj":"T5690","pred":"source","obj":"craft-sa-dev"},{"subj":"T5691","pred":"source","obj":"craft-sa-dev"},{"subj":"T5692","pred":"source","obj":"craft-sa-dev"},{"subj":"T5693","pred":"source","obj":"craft-sa-dev"},{"subj":"T5694","pred":"source","obj":"craft-sa-dev"},{"subj":"T5695","pred":"source","obj":"craft-sa-dev"},{"subj":"T5696","pred":"source","obj":"craft-sa-dev"},{"subj":"T5697","pred":"source","obj":"craft-sa-dev"},{"subj":"T5698","pred":"source","obj":"craft-sa-dev"},{"subj":"T5699","pred":"source","obj":"craft-sa-dev"},{"subj":"T5700","pred":"source","obj":"craft-sa-dev"},{"subj":"T5701","pred":"source","obj":"craft-sa-dev"},{"subj":"T5702","pred":"source","obj":"craft-sa-dev"},{"subj":"T5703","pred":"source","obj":"craft-sa-dev"},{"subj":"T5704","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T5523","span":{"begin":45,"end":52},"obj":"SO:0001023"},{"id":"T5524","span":{"begin":197,"end":203},"obj":"NCBITaxon:9606"},{"id":"T5525","span":{"begin":219,"end":224},"obj":"NCBITaxon:10088"}],"attributes":[{"subj":"T5523","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5524","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T5525","pred":"source","obj":"craft-ca-core-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T5567","span":{"begin":40,"end":44},"obj":"SO_EXT:sequence_nullness"},{"id":"T5568","span":{"begin":45,"end":52},"obj":"SO_EXT:0001023"},{"id":"T5569","span":{"begin":100,"end":113},"obj":"GO_EXT:transcription"},{"id":"T5570","span":{"begin":197,"end":203},"obj":"NCBITaxon:9606"},{"id":"T5571","span":{"begin":219,"end":224},"obj":"NCBITaxon:10088"}],"attributes":[{"subj":"T5567","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T5568","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T5569","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T5570","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T5571","pred":"source","obj":"craft-ca-core-ex-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#ec9393","default":true},{"id":"craft-ca-core-dev","color":"#93adec"},{"id":"craft-ca-core-ex-dev","color":"#c7ec93"}]}]}}